nicorandil has been researched along with cromakalim in 122 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (10.66) | 18.7374 |
| 1990's | 91 (74.59) | 18.2507 |
| 2000's | 12 (9.84) | 29.6817 |
| 2010's | 6 (4.92) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Holzmann, S; Kukovetz, WR; Pöch, G | 1 |
| Berdeaux, A; Drieu la Rochelle, C; Giudicelli, JF; Richard, V | 1 |
| Kreye, VA; Lenz, T; Pfründer, D; Theiss, U | 1 |
| Kamata, K; Kasuya, Y; Miyata, N; Otomo, S; Tsuchida, K; Yamaura, H | 1 |
| Fang, D; Wu, Y | 1 |
| Braida, C; Holzmann, S; Kukovetz, WR; Pöch, G | 1 |
| Cook, D; Stockbridge, N; Vollrath, B; Weir, B; Zhang, H | 1 |
| Akima, M; Imagawa, J; Nabata, H; Taira, N | 1 |
| Ichihara, K; Nagasaka, M; Okumura, K | 1 |
| Kau, ST; Li, JH; Zografos, P | 1 |
| Kamijo, T; Kido, H; Miwa, A; Nakamura, F; Sugimoto, T; Tomaru, T; Uchida, Y | 1 |
| Quast, U | 2 |
| McPherson, GA; Stork, AP | 1 |
| Andersson, KE | 1 |
| Hamilton, TC; Longman, SD | 1 |
| Grover, GJ; Parham, CS; Sleph, PG | 1 |
| Berdeaux, A; Giudicelli, JF; Richer, C | 1 |
| Higuera, TR; Kadowitz, PJ; Kvamme, P; Minkes, RK; Nossaman, BD | 1 |
| Kreye, VA; Lenz, T; Theiss, U | 1 |
| Satoh, K; Taira, N; Yamada, H | 1 |
| Ksoll, E; Mackert, JR; Parsons, AA; Schilling, L; Wahl, M | 1 |
| Arakawa, C; Kasuya, Y; Masuda, Y; Miyajima, M; Shigenobu, K; Tanaka, S; Yamashita, T | 1 |
| Goto, S; Kitagaki, K; Koda, A; Nagai, H; Suda, H | 1 |
| Kurachi, Y; Machulda, MM; Shen, WK; Tung, RT | 1 |
| Cavero, I; Mondot, S; Pratz, J | 1 |
| Stockbridge, N; Weir, B; Zhang, H | 1 |
| Colatsky, T; Follmer, C; Parsons, R; Spinelli, W | 1 |
| Satoh, K; Taira, N; Yamada, H; Yoneyama, F | 1 |
| Taira, N; Teshigawara, T; Yanagisawa, T | 1 |
| Satoh, E; Taira, N; Yanagisawa, T | 1 |
| Satoh, K; Taira, N; Yoneyama, F | 1 |
| Weir, SW; Weston, AH | 2 |
| Coldwell, MC; Howlett, DR | 1 |
| Clapham, JC; Hamilton, TC; Longman, SD; Wilson, C | 1 |
| Hironaka, T; Kim, S; Koh, E; Morimoto, S; Morita, R; Nabata, T; Ogihara, T; Onishi, T; Takamoto, S | 1 |
| Eltze, M | 1 |
| Garrino, MG; Henquin, JC; Plant, TD | 2 |
| Kamata, K; Kasuya, Y; Miyata, N | 1 |
| Coldwell, MC; Cooper, SM; Hamilton, TC; Howlett, DR; Wilson, C | 1 |
| Hashimoto, H; Taira, N; Yanagisawa, T | 1 |
| Clapham, JC; Wilson, C | 1 |
| Kitamura, K; Kuriyama, H; Nakao, K; Okabe, K; Weston, AH | 1 |
| Satoh, H | 2 |
| Kinoshita, M; Nakae, I; Quan, L; Sugimoto, Y; Tsutamoto, T | 1 |
| Attolini, L; Bruguerolle, B; Gantenbein, M | 1 |
| Fukushima, H; Jinno, Y; Kaneta, S; Miwa, A; Ogawa, N | 1 |
| Satake, N; Shibata, S; Zhou, Q | 1 |
| Bender, AS; White, HS; Woodbury, DM | 1 |
| Masuda, Y; Tanaka, S; Yamashita, T | 1 |
| Atwal, KS | 1 |
| Cook, D; Zhang, H | 1 |
| Christensen, H; Drottning, P; Storstein, L | 1 |
| Akamatsu, S; Dohi, S; Iida, H; Ishiyama, T; Ohta, S; Shimonaka, H | 1 |
| Fabiani, ME; Story, DF | 1 |
| Hellwig, B | 1 |
| Hashimoto, K; Kinoshita, M; Nakae, I; Quan, L; Sugimoto, Y; Tsutamoto, T | 1 |
| Fukata, Y; Fukushima, H; Harada, K; Kasai, H; Ogawa, N | 1 |
| Fukata, Y; Fukushima, H; Jinno, Y; Kaneta, S; Ogawa, N; Okada, Y; Yokoyama, T | 1 |
| Cavero, I; Premmereur, J | 1 |
| Abe, S; Kanaide, H; Nakamura, M; Nishimura, J | 1 |
| Andersson, KE; Hedlund, H; Hedlund, P; Holmquist, F | 1 |
| Jun, JY; Kim, KW; Kim, SJ | 1 |
| Kamouchi, M; Kitamura, K | 1 |
| Mori, T; Satoh, K; Taira, N; Yamada, H | 1 |
| Fukata, Y; Fukushima, H; Jinno, Y; Kaneta, S; Miwa, A; Ogawa, N | 1 |
| Satoh, K | 1 |
| Nakaya, H | 1 |
| Fukushima, H; Jinno, Y; Kaneta, S; Kasai, H; Miwa, A; Motoki, K; Ogawa, N; Okada, Y | 1 |
| Allard, B; Lazdunski, M | 1 |
| Okamoto, K; Sakuta, H; Watanabe, Y | 1 |
| Bertaina, V; Heurteaux, C; Lazdunski, M; Widmann, C | 1 |
| Okamoto, K; Sakuta, H | 1 |
| Chiang, CH; Lin, CH | 1 |
| Hara, Y; Kimura, S; Kobayashi, S; Masuda, Y; Nakaya, H; Saito, T; Takizawa, T | 1 |
| Mizoguchi, K; Tanaka, M; Tanaka, T; Yokoo, H; Yoshida, M | 1 |
| Chujo, M; Hori, M; Inoue, M; Kamada, T; Kitakaze, M; Komamura, K; Minamino, T; Mori, H; Node, K; Shinozaki, Y | 1 |
| Hara, Y; Masuda, Y; Nakaya, H; Saito, T; Takizawa, T | 1 |
| Angus, JA; Fujiwara, T | 1 |
| Brading, AF; Teramoto, N | 1 |
| Aya, G; de La Coussaye, JE; Delye, B; Eledjam, JJ; Juan, JM; Péray, P; Robert, E; Sassine, A | 1 |
| Aisaka, K; Hirata, Y | 1 |
| Grover, GJ | 1 |
| Kinoshita, M; Liu, Q; Matsumoto, T; Nakae, I; Omura, T; Takahashi, M; Takaoka, A | 1 |
| Carr, CS; Yellon, DM | 1 |
| Igata, Y; Ikeda, S; Maekawa, T; Shiraishi, M; Watanabe, T; Yamamoto, S | 1 |
| Aisaka, K; Hirata, Y; Mabuchi, Y; Miyai, H | 1 |
| Chen, MJ; Hu, CT; Lee, YM; Sheu, JR; Yen, MH | 1 |
| Saito, K; Sakai, K | 2 |
| Cogolludo, AL; Pérez-Vizcaíno, F; Tamargo, J; Villamor, E | 1 |
| Koyama, T; Matsuzaki, T; Nakasone, J; Noguchi, K; Ojiri, Y; Sakanashi, M | 1 |
| Guo, ZG; Shi, DH | 2 |
| Kamei, K; Kamijo, T; Kamiyama, T; Ohba, Y; Sudo, H; Sugo, I | 1 |
| Aya, AG; Brugada, J; Davy, JM; de la Coussaye, JE; Eledjam, JJ; Juan, JM; Péray, P; Robert, E | 1 |
| Kwan, YW; Lau, WM; To, KW; Tsang, SH | 1 |
| Cogolludo, AL; Fajardo, S; Ibarra, M; Pérez-Vizcaíno, F; Tamargo, J | 1 |
| Aisaka, K; Hirata, Y; Kanada, A; Mabuchi, Y; Miyai, H | 1 |
| Davie, CS; Everitt, DE; Standen, NB | 1 |
| Asano, T; Dohi, S; Iida, H | 1 |
| Furuta, K; Hasuo, H; Sakai, K; Shibata, O; Sumikawa, K; Ureshino, H; Zhang, S | 1 |
| Obata, T; Yamanaka, Y | 1 |
| Hanada, T; Hashimoto, M; Masumura, S; Nakayama, K; Nosaka, S; Saitoh, Y; Sasaki, T; Tamura, K; Yamauchi, M | 1 |
| Tiritilli, A | 1 |
| Iwasaki, T; Kobayashi, S; Miyamoto, T; Ohyanagi, M; Takahashi, K | 1 |
| D'hahan, N; Jacquet, H; Moreau, C; Prost, AL; Vivaudou, M | 1 |
| Ashcroft, FM; Gribble, FM | 1 |
| Asakura, M; Asanuma, H; Harada, K; Hori, M; Kitakaze, M; Kuzuya, T; Mori, H; Node, K; Ogita, H; Sakata, Y; Sanada, S; Shinozaki, Y; Takashima, S | 1 |
| Furuya, H; Inoue, S; Kawaguchi, M; Kitaguchi, K; Kurehara, K; Sakamoto, T | 1 |
| Berg, G; Butler, J; Dominiczak, AF; Hamilton, CA; McIntosh, L; O'Dowd, G; Pathi, V; Reid, JL; Williams, R | 1 |
| Das, B; Sarkar, C | 1 |
| Busija, DW; Horiguchi, T; Kis, B; Nagy, K; Rajapakse, NC; Snipes, JA | 1 |
| Dimitriadis, F; Kinoshita, Y; Ohmasa, F; Saito, M; Satoh, I; Satoh, K; Shimizu, S; Taniguchi, S | 1 |
| Dimitriadis, F; Hayashi, A; Kinoshita, Y; Ohmasa, F; Saito, M; Satoh, K; Shimizu, S; Shomori, K | 1 |
| Dimitriadis, F; Kinoshita, Y; Kitatani, K; Ohmasa, F; Oiwa, H; Saito, M; Satoh, K; Shomori, K; Tsounapi, P | 1 |
| Ishii, K; Moriuchi, H; Nakahara, T; Sakamoto, K; Yunoki, M | 1 |
| Dosa, PI; Fautsch, MP; Roy Chowdhury, U | 1 |
| Nakashima, M; Obata, T | 1 |
13 review(s) available for nicorandil and cromakalim
| Article | Year |
|---|---|
[Advance in pharmacology of potassium channels in cardiovascular system and their clinical use].
Topics: Benzopyrans; Cromakalim; Guanidines; Humans; Muscle, Smooth, Vascular; Myocardium; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Vasodilator Agents | 1992 |
Potassium channel openers: pharmacological and clinical aspects.
Topics: Animals; Benzopyrans; Cardiovascular Diseases; Cromakalim; Heart; Humans; Muscle, Smooth; Nervous System; Niacinamide; Nicorandil; Potassium Channels; Pyrroles; Vasodilator Agents | 1992 |
Clinical pharmacology of potassium channel openers.
Topics: Antihypertensive Agents; Benzopyrans; Cardiovascular System; Cromakalim; Guanidines; Humans; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Respiratory System | 1992 |
Potassium channel activator drugs: mechanism of action, pharmacological properties, and therapeutic potential.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Cardiovascular System; Central Nervous System; Clinical Trials as Topic; Cromakalim; Disease Models, Animal; Guanidines; Humans; Muscle, Smooth, Vascular; Muscles; Neurons; Niacinamide; Nicorandil; Pancreas; Pinacidil; Potassium Channels; Pyrroles; Vasodilator Agents | 1992 |
Pharmacology and structure-activity relationships for KATP modulators: tissue-selective KATP openers.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Antihypertensive Agents; Benzopyrans; Cardiovascular Diseases; Cromakalim; Diazoxide; Guanidines; Guinea Pigs; Minoxidil; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Picolines; Pinacidil; Potassium Channels; Pyrans; Pyrroles; Radioligand Assay; Rats; Structure-Activity Relationship; Vasodilator Agents | 1994 |
Cerebral vascular smooth muscle potassium channels and their possible role in the management of vasospasm.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Calcium; Cromakalim; Electrophysiology; Guanidines; Ischemic Attack, Transient; Muscle, Smooth, Vascular; Neuropeptides; Niacinamide; Nicorandil; Nitric Oxide; Pinacidil; Potassium Channels; Pyrroles; Vasoconstriction; Vasodilator Agents | 1994 |
[Potassium agonists].
Topics: Animals; Benzopyrans; Calcium; Cromakalim; Humans; Membrane Potentials; Muscle, Smooth, Vascular; Myocardial Ischemia; Neuromuscular Junction; Niacinamide; Nicorandil; Potassium; Potassium Channels; Pyrroles; Vascular Resistance; Vasodilator Agents | 1994 |
Do the K+ channel openers relax smooth muscle by opening K+ channels?
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Calcium; Cromakalim; Humans; Inositol 1,4,5-Trisphosphate; Membrane Potentials; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Potassium; Potassium Channels; Pyrroles; Vasodilator Agents | 1993 |
[Ca-antagonist, K-channel-opener in the treatment of patients with congestive heart failure].
Topics: Animals; Benzopyrans; Calcium Channel Blockers; Cromakalim; Guanidines; Heart Failure; Hemodynamics; Humans; In Vitro Techniques; Ion Channel Gating; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Vasodilator Agents | 1993 |
[Potential role of ATP-sensitive K+ channels in ischemia- and reperfusion-induced arrhythmias].
Topics: Action Potentials; Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Benzopyrans; Cromakalim; Glyburide; Guanidines; Humans; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Niacinamide; Nicorandil; Pinacidil; Potassium; Potassium Channels; Pyrroles; Tolbutamide | 1993 |
Pharmacology of ATP-sensitive potassium channel (KATP) openers in models of myocardial ischemia and reperfusion.
Topics: Animals; ATP-Binding Cassette Transporters; Benzopyrans; Cromakalim; Guanidines; Humans; Ischemic Preconditioning, Myocardial; KATP Channels; Mitochondria, Heart; Models, Cardiovascular; Myocardial Ischemia; Myocardial Reperfusion; Niacinamide; Nicorandil; Picolines; Pinacidil; Potassium Channels; Potassium Channels, Inwardly Rectifying; Pyrans; Pyrroles; Rats | 1997 |
New windows on the mechanism of action of K(ATP) channel openers.
Topics: Adenosine Triphosphate; Animals; Binding Sites; Cromakalim; Diazoxide; Humans; Minoxidil; Nicorandil; Pinacidil; Potassium Channels | 2000 |
ATP sensitive potassium channel openers: A new class of ocular hypotensive agents.
Topics: Animals; Antihypertensive Agents; Cromakalim; Diazoxide; Glaucoma; Humans; Intraocular Pressure; KATP Channels; Nicorandil; Trabecular Meshwork | 2017 |
1 trial(s) available for nicorandil and cromakalim
| Article | Year |
|---|---|
Effect of angiotensin-converting enzyme inhibitors and nitroxy groups on human coronary resistance vessels in vitro.
Topics: Angiotensin-Converting Enzyme Inhibitors; Coronary Vessels; Cromakalim; Endothelium, Vascular; Female; Humans; In Vitro Techniques; Male; Middle Aged; Neurosecretory Systems; Nicorandil; Nitroglycerin; Stress, Mechanical; Sulfhydryl Compounds; Vascular Resistance; Vasodilator Agents | 2000 |
108 other study(ies) available for nicorandil and cromakalim
| Article | Year |
|---|---|
Molecular mechanism of action of nicorandil.
Topics: Animals; Benzopyrans; Cattle; Coronary Vessels; Cromakalim; Cyclic GMP; Dose-Response Relationship, Drug; In Vitro Techniques; Niacinamide; Nicorandil; Nitroglycerin; Nitroprusside; Pyrroles; Vasodilation; Vasodilator Agents | 1992 |
Differential effects of nitrovasodilators, K(+)-channel openers, and nicorandil on large and small coronary arteries in conscious dogs.
Topics: Animals; Benzopyrans; Coronary Vessels; Cromakalim; Dogs; Dose-Response Relationship, Drug; Injections, Intravenous; Molsidomine; Niacinamide; Nicorandil; Nifedipine; Nitroglycerin; Potassium Channels; Pyrroles; Vasodilation; Vasodilator Agents | 1992 |
Pharmacological characterization of nicorandil by 86Rb efflux and isometric vasorelaxation studies in vascular smooth muscle.
Topics: Animals; Aorta; Benzopyrans; Cromakalim; Glyburide; In Vitro Techniques; Niacinamide; Nicorandil; Nitroprusside; Potassium Channels; Pyrroles; Rabbits; Rubidium Radioisotopes; Vasodilation; Vasodilator Agents | 1992 |
Changes in responsiveness of the aorta to vasorelaxant agents in genetically diabetic rats: a study in WBN/Kob rats.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Colforsin; Cromakalim; Diabetes Mellitus, Experimental; Endothelium, Vascular; Isoproterenol; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Pyrroles; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Vasodilator Agents | 1992 |
Pharmacological interaction experiments differentiate between glibenclamide-sensitive K+ channels and cyclic GMP as components of vasodilation by nicorandil.
Topics: Animals; Benzopyrans; Cattle; Coronary Vessels; Cromakalim; Cyclic GMP; Drug Interactions; Glyburide; Guanidines; In Vitro Techniques; Methylene Blue; Molsidomine; Muscle Relaxation; Niacinamide; Nicorandil; Nitroprusside; Pinacidil; Potassium Channels; Pyrroles; Sensitivity and Specificity; Vasodilator Agents | 1992 |
Vasodilatation of canine cerebral arteries by nicorandil, pinacidil and lemakalim.
Topics: Animals; Basilar Artery; Benzopyrans; Cerebral Arteries; Cromakalim; Dogs; Female; Glyburide; Guanidines; Guanylate Cyclase; In Vitro Techniques; Male; Methylene Blue; Muscle Contraction; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Vasodilation; Vasodilator Agents | 1992 |
Spasmolytic action of nicorandil in canine conductive coronary arteries in vivo is not modified by glibenclamide.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Angiocardiography; Animals; Benzopyrans; Coronary Circulation; Coronary Vasospasm; Coronary Vessels; Cromakalim; Dogs; Female; Glyburide; Male; Niacinamide; Nicorandil; Nitroglycerin; Parasympatholytics; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Vasodilator Agents | 1992 |
Effects of imidazoline-related compounds on the mechanical response to nicorandil in the rat portal vein.
Topics: Animals; Benzopyrans; Cromakalim; Imidazoles; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Portal Vein; Potassium Channels; Pyrroles; Rats; Rats, Wistar | 1992 |
Comparison of the in vitro effects of K+ channel modulators on detrusor and portal vein strips from guinea pigs.
Topics: Animals; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Guanidines; Guinea Pigs; In Vitro Techniques; Male; Minoxidil; Muscle, Smooth; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Pinacidil; Portal Vein; Potassium Channels; Potassium Chloride; Pyrroles; Vasoconstriction; Vasodilator Agents | 1992 |
[The vasospasmolytic effects of nicorandil, cromakalim and pinacidil on 3,4-diaminopyridine-induced phasic contractions in canine coronary arteries as an experimental vasospasm model].
Topics: 4-Aminopyridine; Amifampridine; Animals; Benzopyrans; Coronary Vasospasm; Cromakalim; Disease Models, Animal; Dogs; Female; Glyburide; Guanidines; In Vitro Techniques; Ion Channel Gating; Male; Methylene Blue; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Vasodilator Agents | 1992 |
The resistance of some rat cerebral arteries to the vasorelaxant effect of cromakalim and other K+ channel openers.
Topics: Acetylcholine; Animals; Antihypertensive Agents; Benzopyrans; Cerebellum; Cerebral Arteries; Cromakalim; Guanidines; Guinea Pigs; Niacinamide; Nicorandil; Nitric Oxide; Nitroglycerin; Pinacidil; Potassium Channels; Pyrroles; Rabbits; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vascular Resistance; Vasodilator Agents | 1992 |
Nicorandil improves postischemic contractile function independently of direct myocardial effects.
Topics: Animals; Benzopyrans; Coronary Circulation; Coronary Disease; Cromakalim; Dogs; Heart Function Tests; Heart Rate; In Vitro Techniques; L-Lactate Dehydrogenase; Male; Myocardial Contraction; Myocardium; Niacinamide; Nicorandil; Perfusion; Pyrroles; Rats; Rats, Inbred Strains | 1990 |
[Potassium channel activators. Perspectives in the treatment of arterial hypertension].
Topics: Antihypertensive Agents; Benzopyrans; Cromakalim; Guanidines; Humans; Hypertension; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles | 1991 |
Analysis of pulmonary and systemic vascular responses to cromakalim, an activator of K+ATP channels.
Topics: Adenosine Triphosphate; Animals; Antihypertensive Agents; Benzopyrans; Blood Circulation; Cats; Cromakalim; Endothelins; Glyburide; Guanidines; Heart Rate; Hindlimb; Myocardial Contraction; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pulmonary Circulation; Pyrroles; Vascular Resistance; Vasodilator Agents; Ventricular Function, Right | 1991 |
The dualistic mode of action of the vasodilator drug, nicorandil, differentiated by glibenclamide in 86Rb flux studies in rabbit isolated vascular smooth muscle.
Topics: Animals; Aorta; Benzopyrans; Cromakalim; Glyburide; Membranes; Muscle Contraction; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Norepinephrine; Potassium; Potassium Channels; Pyrroles; Rabbits; Rubidium Radioisotopes; Stimulation, Chemical; Vasodilator Agents | 1991 |
Differential antagonism by glibenclamide of the relaxant effects of cromakalim, pinacidil and nicorandil on canine large coronary arteries.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Arteries; Benzopyrans; Coronary Vessels; Cromakalim; Dogs; Dose-Response Relationship, Drug; Female; Glyburide; Guanidines; Male; Methylene Blue; Muscle Contraction; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitroglycerin; Pinacidil; Potassium; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Vasodilator Agents | 1991 |
Analysis of cromakalim-, pinacidil-, and nicorandil-induced relaxation of the 5-hydroxytryptamine precontracted rat isolated basilar artery.
Topics: Animals; Basilar Artery; Benzopyrans; Cromakalim; Drug Interactions; Glyburide; Guanidines; Male; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists; Vasoconstriction; Vasodilation; Vasodilator Agents | 1991 |
Potassium channel opening properties of a novel compound, NIP-121, cromakalim and nicorandil in rat aorta and portal vein.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Benzopyrans; Cromakalim; Glyburide; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Oxadiazoles; Phentolamine; Piperidines; Portal Vein; Potassium Channels; Potassium Chloride; Pyrroles; Rats; Rats, Inbred Strains; Rubidium Radioisotopes | 1991 |
Effect of three novel K+ channel openers, cromakalim, pinacidil and nicorandil on allergic reaction and experimental asthma.
Topics: Airway Resistance; Animals; Asthma; Benzopyrans; Bronchodilator Agents; Cromakalim; Guanidines; Guinea Pigs; In Vitro Techniques; Mice; Mice, Inbred Strains; Niacinamide; Nicorandil; Passive Cutaneous Anaphylaxis; Pinacidil; Potassium Channels; Pyrroles; Rats; Trachea; Vasculitis | 1991 |
Essential role of nucleotide diphosphates in nicorandil-mediated activation of cardiac ATP-sensitive K+ channel. A comparison with pinacidil and lemakalim.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Guanidines; Myocardium; Niacinamide; Nicorandil; Phosphorylation; Pinacidil; Potassium Channels; Pyrroles; Vasodilator Agents | 1991 |
K+ channel opening mediates the vasorelaxant effects of nicorandil in the intact vascular system.
Topics: Animals; Benzopyrans; Cromakalim; Dogs; Dose-Response Relationship, Drug; Female; Male; Membrane Potentials; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Potassium Channels; Pyrroles; Rats; Rats, Inbred SHR; Vasoconstriction; Vasodilation; Vasodilator Agents | 1991 |
Effects of pinacidil, cromakalim, and nicorandil on potassium currents of rat basilar artery smooth muscle.
Topics: Animals; Antihypertensive Agents; Basilar Artery; Benzopyrans; Calcium; Cerebrovascular Circulation; Cromakalim; Electrophysiology; Guanidines; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains | 1991 |
Effects of cromakalim, pinacidil and nicorandil on cardiac refractoriness and arterial pressure in open-chest dogs.
Topics: Animals; Atrioventricular Node; Benzopyrans; Blood Pressure; Cromakalim; Dogs; Dose-Response Relationship, Drug; Electrocardiography; Female; Guanidines; Heart Conduction System; Heart Rate; Male; Neural Conduction; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Refractory Period, Electrophysiological | 1990 |
Specific but differential antagonism by glibenclamide of the vasodepressor effects of cromakalim and nicorandil in spinally-anaesthetized dogs.
Topics: Anesthesia, Spinal; Animals; Benzopyrans; Blood Pressure; Calcium Channel Blockers; Cromakalim; Diltiazem; Dogs; Dose-Response Relationship, Drug; Female; Glyburide; Heart Rate; Hemodynamics; Male; Myocardial Contraction; Niacinamide; Nicorandil; Nitroglycerin; Norepinephrine; Potassium Channels; Pyrroles | 1990 |
Cytoplasmic calcium and the relaxation of canine coronary arterial smooth muscle produced by cromakalim, pinacidil and nicorandil.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Calcium; Coronary Vessels; Cromakalim; Cytoplasm; Dogs; Female; Fluorescence; Glyburide; Guanidines; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Pinacidil; Potassium Chloride; Pyrroles; Quaternary Ammonium Compounds | 1990 |
Specific antagonism by glibenclamide of negative inotropic effects of potassium channel openers in canine atrial muscle.
Topics: Animals; Benzopyrans; Carbachol; Cromakalim; Dogs; Female; Glyburide; Guanidines; Heart Atria; Male; Myocardial Contraction; Niacinamide; Nicorandil; Nifedipine; Pinacidil; Potassium Channels; Pyrroles; Vasodilator Agents | 1990 |
Nicorandil increases coronary blood flow predominantly by K-channel opening mechanism.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Coronary Circulation; Cromakalim; Dogs; Dose-Response Relationship, Drug; Female; Glyburide; In Vitro Techniques; Male; Myocardial Contraction; Niacinamide; Nicorandil; Nitroglycerin; Potassium Channels; Pyrroles; Vasodilator Agents | 1990 |
Effect of apamin on responses to BRL 34915, nicorandil and other relaxants in the guinea-pig taenia caeci.
Topics: Adenosine Triphosphate; Animals; Antihypertensive Agents; Apamin; Bee Venoms; Benzopyrans; Cecum; Cromakalim; Female; Guinea Pigs; In Vitro Techniques; Ion Channels; Isoproterenol; Male; Muscle Relaxants, Central; Muscle Tonus; Muscle, Smooth; Niacinamide; Nicorandil; Norepinephrine; Pyrroles | 1986 |
The effects of BRL 34915 and nicorandil on electrical and mechanical activity and on 86Rb efflux in rat blood vessels.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Benzopyrans; Cromakalim; In Vitro Techniques; Ion Channels; Male; Membrane Potentials; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Norepinephrine; Portal Vein; Pyrroles; Radioisotopes; Rats; Rats, Inbred Strains; Rubidium; Time Factors | 1986 |
Specificity of action of the novel antihypertensive agent, BRL 34915, as a potassium channel activator. Comparison with nicorandil.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Antihypertensive Agents; Apamin; Benzopyrans; Binding Sites; Cromakalim; Cyclic AMP; Cyclic GMP; Inositol Phosphates; Ion Channels; Male; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitrendipine; Potassium; Pyrroles; Rats; Rats, Inbred Strains; Rubidium; Tetraethylammonium Compounds | 1987 |
Cromakalim, a potassium channel activator: a comparison of its cardiovascular haemodynamic profile and tissue specificity with those of pinacidil and nicorandil.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Cats; Coronary Circulation; Cromakalim; Female; Guanidines; Hemodynamics; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Organ Specificity; Papillary Muscles; Pinacidil; Portal Vein; Potassium Channels; Pyrroles; Rabbits | 1988 |
Effects of valinomycin on calcium mobilization in vascular smooth muscle cells induced by angiotensin II.
Topics: Angiotensin II; Animals; Benzopyrans; Calcium; Cromakalim; Endothelium, Vascular; Ethers; Female; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Ionomycin; Ionophores; Monensin; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Pyrroles; Rats; Valinomycin | 1989 |
Glibenclamide is a competitive antagonist of cromakalim, pinacidil and RP 49356 in guinea-pig pulmonary artery.
Topics: Animals; Benzopyrans; Cromakalim; Glyburide; Guanidines; Guinea Pigs; In Vitro Techniques; Male; Methylene Blue; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Picolines; Pinacidil; Potassium Channels; Potassium Chloride; Pulmonary Artery; Purinones; Pyrans; Pyrroles; Tetraethylammonium Compounds | 1989 |
Comparison of the effects of putative activators of K+ channels on pancreatic B-cell function.
Topics: Animals; Benzopyrans; Cromakalim; Diazoxide; Guanidines; In Vitro Techniques; Islets of Langerhans; Mice; Minoxidil; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Vasodilator Agents | 1989 |
Functional changes in potassium channels in aortas from rats with streptozotocin-induced diabetes.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Blood Glucose; Cromakalim; Diabetes Mellitus, Experimental; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Niacinamide; Nicorandil; Norepinephrine; Parasympatholytics; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains | 1989 |
Effects of putative activators of K+ channels in mouse pancreatic beta-cells.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Diazoxide; Electrophysiology; Female; Glucose; Guanidines; Homeostasis; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Membrane Potentials; Mice; Minoxidil; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Rubidium Radioisotopes | 1989 |
Comparative effects of K+ channel blockade on the vasorelaxant activity of cromakalim, pinacidil and nicorandil.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Benzopyrans; Cardiovascular Agents; Cromakalim; Guanidines; In Vitro Techniques; Male; Mesenteric Arteries; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Procaine; Pyrroles; Rabbits; Rubidium Radioisotopes; Tetraethylammonium Compounds; Vasodilator Agents | 1988 |
The negative inotropic effect of nicorandil is independent of cyclic GMP changes: a comparison with pinacidil and cromakalim in canine atrial muscle.
Topics: Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Benzopyrans; Cromakalim; Cyclic AMP; Cyclic GMP; Dogs; Female; Guanidines; In Vitro Techniques; Male; Monoamine Oxidase Inhibitors; Myocardial Contraction; Myocardium; Niacinamide; Nicorandil; Nifedipine; Pinacidil; Potassium Channels; Pyrroles; Tetraethylammonium Compounds; Vasodilator Agents | 1988 |
Anti-spasmogenic and spasmolytic effects of BRL 34915: a comparison with nifedipine and nicorandil.
Topics: Animals; Benzopyrans; Cromakalim; Electric Stimulation; In Vitro Techniques; Male; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nifedipine; Norepinephrine; Parasympatholytics; Potassium Chloride; Pyrroles; Rabbits | 1987 |
Characteristics of cromakalim-induced relaxations in the smooth muscle cells of guinea-pig mesenteric artery and vein.
Topics: Action Potentials; Animals; Antihypertensive Agents; Benzopyrans; Cromakalim; Female; Guinea Pigs; In Vitro Techniques; Male; Membrane Potentials; Mesenteric Arteries; Mesenteric Veins; Microelectrodes; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Potassium Channels; Pyrroles; Vasodilator Agents | 1988 |
Effects of ATP-sensitive K+ channel openers on pacemaker activity in isolated single rabbit sino-atrial node cells.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Electrophysiology; Glyburide; Guanidines; Heart Rate; In Vitro Techniques; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Rabbits; Sinoatrial Node; Vasodilator Agents | 1993 |
Glibenclamide-induced oscillation of canine coronary artery is independent of myocardial ischemia.
Topics: Adenosine Triphosphate; Animals; Arginine; Benzopyrans; Coronary Circulation; Coronary Vessels; Cromakalim; Diltiazem; Dogs; Female; Glyburide; In Vitro Techniques; Male; Muscle Tonus; Muscle, Smooth, Vascular; Myocardial Ischemia; Niacinamide; Nicorandil; Nitroarginine; Nitroglycerin; Potassium Channels; Pyrroles; Vasodilator Agents | 1994 |
Effect of four potassium channel agonists on bupivacaine-induced toxicity in mice.
Topics: Animals; Benzopyrans; Bupivacaine; Cromakalim; Diazoxide; Dose-Response Relationship, Drug; Guanidines; Male; Mice; Mice, Inbred Strains; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Seizures | 1995 |
Effect of KRN2391 on venous return: comparison with other vasodilators.
Topics: Animals; Benzopyrans; Cromakalim; Dogs; Female; Glyburide; Hemodynamics; Male; Niacinamide; Nicorandil; Nifedipine; Nitroglycerin; Potassium Channels; Pyridines; Pyrroles; Vasodilator Agents; Veins | 1993 |
The inhibitory mechanisms of nicorandil in isolated rat urinary bladder and femoral artery.
Topics: Acetylcholine; Animals; Benzopyrans; Cromakalim; Cyclic GMP; Electric Stimulation; Femoral Artery; Guanylate Cyclase; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitroglycerin; Potassium Channels; Potassium Chloride; Pyrroles; Rats; Rats, Wistar; Urinary Bladder; Vasodilator Agents | 1995 |
Ionic dependence of adenosine uptake into cultured astrocytes.
Topics: Adenosine; Animals; Animals, Newborn; Astrocytes; Benzopyrans; Biological Transport; Calcimycin; Calcium; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cells, Cultured; Cerebral Cortex; Cromakalim; Furosemide; Glyburide; Ionophores; Kinetics; Mice; Niacinamide; Nicorandil; Nigericin; Omeprazole; Potassium; Pyrroles; Sodium; Valinomycin; Vasodilator Agents | 1994 |
Potassium channel openers relax A23187-induced nifedipine-resistant contraction of rat aorta.
Topics: Animals; Aorta; Benzopyrans; Calcimycin; Cromakalim; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nifedipine; Oxadiazoles; Piperidines; Pyrroles; Rats; Rats, Wistar; Vasoconstriction; Vasodilator Agents | 1994 |
[Potassium channel openers. A new possible therapeutic principle in several diseases].
Topics: Antihypertensive Agents; Benzopyrans; Bronchodilator Agents; Cromakalim; Guanidines; Humans; Minoxidil; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Vasodilator Agents | 1994 |
Mechanisms of vasodilation of cerebral vessels induced by the potassium channel opener nicorandil in canine in vivo experiments.
Topics: Administration, Topical; Animals; Arterioles; Benzopyrans; Cromakalim; Dimethyl Sulfoxide; Dogs; Glyburide; Methylene Blue; Microcirculation; Niacinamide; Nicorandil; Nitroglycerin; Pia Mater; Pyrroles; Vasodilation; Vasodilator Agents; Venules | 1994 |
Prejunctional effects of cromakalim, nicorandil and pinacidil on noradrenergic transmission in rat isolated mesenteric artery.
Topics: Animals; Benzopyrans; Calcium; Cromakalim; Desipramine; Electric Stimulation; Extracellular Space; Female; Guanidines; In Vitro Techniques; Male; Mesenteric Arteries; Neuromuscular Junction; Niacinamide; Nicorandil; Norepinephrine; Pargyline; Phentolamine; Pinacidil; Pyrroles; Rats; Rats, Sprague-Dawley; Sympathetic Nervous System; Synaptic Transmission; Vasodilator Agents | 1994 |
Mechanism of the vasodilatory action of nicorandil on coronary circulation in dogs.
Topics: Animals; Benzopyrans; Coronary Circulation; Coronary Vessels; Cromakalim; Dogs; Dose-Response Relationship, Drug; Female; Glyburide; Hemodynamics; Injections, Intravenous; Male; Niacinamide; Nicorandil; Nitroglycerin; Potassium Channels; Pyrroles; Vasodilator Agents | 1994 |
Dissimilarity in the mechanisms of action of KRN2391, nicorandil and cromakalim in canine renal artery.
Topics: Animals; Benzopyrans; Cromakalim; Dogs; Female; Glyburide; In Vitro Techniques; Male; Methylene Blue; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitrates; Potassium Channels; Potassium Chloride; Pyridines; Pyrroles; Renal Artery; Vasodilator Agents | 1993 |
Mechanism of action of KRN2391 in canine coronary vascular bed.
Topics: Animals; Antihypertensive Agents; Arteries; Benzopyrans; Coronary Circulation; Coronary Vessels; Cromakalim; Dogs; Drug Interactions; Female; Glyburide; In Vitro Techniques; Male; Methylene Blue; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Pyridines; Pyrroles; Vasodilator Agents | 1993 |
ATP sensitive potassium channel openers are of potential benefit in ischaemic heart disease.
Topics: Benzopyrans; Cromakalim; Dihydropyridines; Guanidines; Humans; Myocardial Ischemia; Myocardium; Niacinamide; Nicorandil; Picolines; Pinacidil; Potassium Channels; Pyrans; Pyrroles; Sodium-Potassium-Exchanging ATPase; Vasodilator Agents | 1994 |
Effects of nicorandil on cytosolic calcium concentrations and on tension development in the rabbit femoral artery.
Topics: Animals; Benzopyrans; Calcium; Cromakalim; Cyclic GMP; Femoral Artery; Glyburide; In Vitro Techniques; Male; Niacinamide; Nicorandil; Nitroglycerin; Norepinephrine; Potassium; Potassium Channels; Pyrroles; Rabbits; Vasodilation; Vasodilator Agents | 1994 |
Effects of nicorandil on human isolated corpus cavernosum and cavernous artery.
Topics: Adult; Aged; Benzopyrans; Cromakalim; Humans; In Vitro Techniques; Male; Middle Aged; Molsidomine; Niacinamide; Nicorandil; Penis; Potassium Channels; Pyrroles; Vasodilator Agents | 1994 |
Effects of K-channel openers on the contractility and electrical activity of antral circular muscle in guinea-pig stomach.
Topics: Action Potentials; Animals; Benzopyrans; Cromakalim; Glyburide; Guinea Pigs; In Vitro Techniques; Ion Channel Gating; Muscle Contraction; Muscle, Smooth; Niacinamide; Nicorandil; Potassium Channels; Pyrroles; Stomach | 1993 |
Regulation of ATP-sensitive K+ channels by ATP and nucleotide diphosphate in rabbit portal vein.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Egtazic Acid; Guanidines; In Vitro Techniques; Ion Channel Gating; Magnesium; Male; Membrane Potentials; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Pinacidil; Portal Vein; Potassium Channels; Probability; Pyrroles; Rabbits; Ribonucleotides; Time Factors; Vasodilator Agents | 1994 |
Nicorandil as a nitrate, and cromakalim as a potassium channel opener, dilate isolated porcine large coronary arteries in an agonist-nonselective manner.
Topics: Animals; Benzopyrans; Coronary Vessels; Cromakalim; Glyburide; In Vitro Techniques; Niacinamide; Nicorandil; Nitrates; Potassium Channels; Pyrroles; Swine; Vasodilator Agents | 1993 |
Mechanism of action of KRN2391, a novel vasodilator, in canine mesenteric artery.
Topics: Animals; Arterioles; Benzopyrans; Cromakalim; Dogs; Female; Glyburide; In Vitro Techniques; Male; Mesenteric Arteries; Methylene Blue; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Pyridines; Pyrroles; Splanchnic Circulation; Vascular Resistance; Vasodilator Agents | 1993 |
Vasorelaxant mechanism of KRN2391 and nicorandil in porcine coronary arteries of different sizes.
Topics: Animals; Benzopyrans; Coronary Vessels; Cromakalim; Glyburide; In Vitro Techniques; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitroglycerin; Oxyhemoglobins; Potassium Channels; Pyridines; Pyrroles; Swine; Vasodilator Agents | 1993 |
Pharmacological properties of ATP-sensitive K+ channels in mammalian skeletal muscle cells.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Electrophysiology; Glyburide; Guanidines; In Vitro Techniques; Mice; Muscles; Niacinamide; Nicorandil; Organic Chemicals; Pinacidil; Potassium Channels; Pyrroles; Vasodilator Agents | 1993 |
Comparative electrophysiological and mechanical actions of ATP-sensitive potassium channel openers in canine Purkinje fibers.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Dogs; Electrophysiology; Glyburide; Guanidines; In Vitro Techniques; Myocardial Contraction; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Purkinje Fibers; Pyrroles; Tetraethylammonium Compounds; Vasodilator Agents | 1993 |
Modification by cGMP of glibenclamide-sensitive K+ currents in Xenopus oocytes.
Topics: Animals; Benzopyrans; Cromakalim; Cyclic GMP; Female; Glyburide; In Vitro Techniques; Membrane Potentials; Methylene Blue; Niacinamide; Nicorandil; Nitroprusside; Oocytes; Potassium Channels; Pyridines; Pyrroles; Xenopus laevis | 1993 |
K+ channel openers prevent global ischemia-induced expression of c-fos, c-jun, heat shock protein, and amyloid beta-protein precursor genes and neuronal death in rat hippocampus.
Topics: Alternative Splicing; Amyloid beta-Protein Precursor; Animals; Base Sequence; Benzopyrans; Brain Ischemia; Cell Death; Cromakalim; Gene Expression Regulation; Guanidines; Heat-Shock Proteins; Hippocampus; In Situ Hybridization; Male; Molecular Sequence Data; Neurons; Niacinamide; Nicorandil; Oligonucleotide Probes; Pinacidil; Potassium Channels; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Pyrroles; Rats; Rats, Wistar; RNA, Messenger | 1993 |
Activation by KRN2391 and nicorandil of glibenclamide-sensitive K+ channels in Xenopus oocytes.
Topics: Animals; Benzopyrans; Cromakalim; Electrophysiology; Epinephrine; Female; Glyburide; Niacinamide; Nicorandil; Oocytes; Phentolamine; Potassium Channels; Pyridines; Pyrroles; Trifluoperazine; Vasodilator Agents; Xenopus laevis | 1993 |
Effects of cromakalim and nicorandil on intraocular pressure after topical administration in rabbit eyes.
Topics: Administration, Topical; Animals; Antihypertensive Agents; Benzopyrans; Blood Flow Velocity; Chymotrypsin; Cromakalim; Eye; Female; Intraocular Pressure; Male; Niacinamide; Nicorandil; Ocular Hypertension; Ophthalmic Solutions; Potassium Channels; Pyrroles; Rabbits | 1995 |
Endothelin-1 partially inhibits ATP-sensitive K+ current in guinea pig ventricular cells.
Topics: Action Potentials; Adenosine Triphosphate; Alkaloids; Animals; Azepines; Benzopyrans; Cromakalim; Endothelin Receptor Antagonists; Endothelins; Female; Glyburide; Guinea Pigs; Heart; Heart Ventricles; Hypoglycemic Agents; Male; Niacinamide; Nicorandil; Oligopeptides; Papillary Muscles; Potassium Channels; Protein Kinase C; Pyrroles; Staurosporine; Sulfonamides; Vasodilator Agents | 1996 |
ATP-sensitive K+ channel openers block sulpiride-induced dopamine release in the rat striatum.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Dopamine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Male; Microdialysis; Monoamine Oxidase Inhibitors; Neostriatum; Nerve Endings; Niacinamide; Nicorandil; Potassium Channels; Pyrroles; Rats; Rats, Wistar; Substantia Nigra; Sulpiride; Vasodilator Agents | 1996 |
Role of activation of ectosolic 5'-nucleotidase in the cardioprotection mediated by opening of K+c channels.
Topics: 5'-Nucleotidase; Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Dogs; Enzyme Activation; Glyburide; Heart; Hemodynamics; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; Niacinamide; Nicorandil; Potassium Channels; Pyrroles; Recurrence | 1996 |
alpha 1-Adrenoceptor stimulation partially inhibits ATP-sensitive K+ current in guinea pig ventricular cells: attenuation of the action potential shortening induced by hypoxia and K+ channel openers.
Topics: Action Potentials; Adrenergic alpha-Agonists; Animals; Benzopyrans; Cells, Cultured; Cromakalim; Female; Guinea Pigs; Heart; Heart Ventricles; Hypoxia; Male; Methoxamine; Niacinamide; Nicorandil; Papillary Muscles; Patch-Clamp Techniques; Potassium Channels; Pyrroles; Ventricular Function | 1996 |
Analysis of relaxation and repolarization mechanisms of nicorandil in rat mesenteric artery.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Benzopyrans; Calcium Channel Blockers; Cromakalim; Electrophysiology; Glyburide; Hypoglycemic Agents; In Vitro Techniques; Male; Membrane Potentials; Mesenteric Arteries; Methylene Blue; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nifedipine; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Rats; Rats, Sprague-Dawley; Thromboxane A2; Vasoconstrictor Agents; Vasodilator Agents | 1996 |
Nicorandil activates glibenclamide-sensitive K+ channels in smooth muscle cells of pig proximal urethra.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Cyclic GMP; Female; Glyburide; Membrane Potentials; Muscle, Smooth; Niacinamide; Nicorandil; Potassium Channels; Pyrroles; Swine; Urethra | 1997 |
Comparison of proarrhythmogenic effects of two potassium channel openers, levcromakalim (BRL 38227) and nicorandil (RP 46417): a high-resolution mapping study on rabbit heart.
Topics: Animals; Arrhythmias, Cardiac; Benzopyrans; Bradycardia; Cromakalim; Dose-Response Relationship, Drug; Electrophysiology; Heart; In Vitro Techniques; Isosorbide Dinitrate; Niacinamide; Nicorandil; Potassium Channels; Pyrroles; Rabbits; Tachycardia; Vasodilator Agents; Ventricular Fibrillation | 1997 |
Effect of JTV-506, a novel vasodilator, on coronary blood flow in conscious dogs.
Topics: Administration, Oral; Animals; Benzopyrans; Blood Pressure; Chromans; Coronary Circulation; Cromakalim; Diltiazem; Dogs; Dose-Response Relationship, Drug; Female; Heart Rate; Injections, Intravenous; Male; Niacinamide; Nicorandil; Nitroglycerin; Pyrroles; Vasodilator Agents | 1997 |
Heterogeneity in the vasorelaxing effect of nicorandil on dog epicardial coronary arteries: comparison with other NO donors.
Topics: Animals; Atrial Natriuretic Factor; Benzopyrans; Coronary Vessels; Cromakalim; Cyclic GMP; Dogs; Female; Glyburide; In Vitro Techniques; Male; Methylene Blue; Molsidomine; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitric Oxide; Nitroglycerin; Nitroprusside; Oxyhemoglobins; Pyrroles; Vasodilator Agents | 1997 |
Ischaemic preconditioning may abolish the protection afforded by ATP-sensitive potassium channel openers in isolated human atrial muscle.
Topics: Adenosine Triphosphate; Adult; Aged; Angina Pectoris; Benzopyrans; Cromakalim; Female; Guanidines; Heart Atria; Humans; Ischemic Preconditioning, Myocardial; Male; Middle Aged; Myocardial Contraction; Niacinamide; Nicorandil; Potassium Channels; Vasodilator Agents | 1997 |
Synthesis and biological activity of novel 2-(alpha-alkoxyimino)benzylpyridine derivatives as K+ channel openers.
Topics: Administration, Oral; Animals; Aorta, Thoracic; Blood Pressure; Coronary Circulation; Cromakalim; Cyclic N-Oxides; Diltiazem; Dogs; Hypertension; Male; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitroglycerin; Potassium Channels; Pyridines; Rats; Rats, Inbred SHR; Rats, Wistar; Structure-Activity Relationship; Vasodilation; Vasodilator Agents | 1997 |
Effect of JTV-506, a novel vasodilator, on experimental angina model in rats.
Topics: Administration, Oral; Angina Pectoris; Animals; Arginine Vasopressin; Blood Pressure; Chromans; Cromakalim; Dose-Response Relationship, Drug; Electrocardiography; Heart Rate; Injections, Intravenous; Male; Methacholine Chloride; Molecular Structure; Niacinamide; Nicorandil; Nifedipine; Rats; Rats, Sprague-Dawley; Vasoconstrictor Agents; Vasodilator Agents | 1998 |
ATP-sensitive potassium-channel-opening activity of CL-065, a 3-[(substituted-carbonyl)amino]-2H-1-benzopyran, in the rat.
Topics: Animals; Antihypertensive Agents; Aorta; Benzopyrans; Blood Pressure; Cromakalim; Female; Heart Rate; Male; Niacinamide; Nicorandil; Potassium Channels; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Vasodilation | 1998 |
Enhancement of the vasodepressor response to adenosine by nicorandil in rats: comparison with cromakalim.
Topics: Adenosine; Adenosine Triphosphate; Animals; Blood Pressure; Cromakalim; Drug Synergism; Glyburide; Heart Rate; Male; Niacinamide; Nicorandil; Potassium Channels; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 1998 |
Role of K+ channel opening and stimulation of cyclic GMP in the vasorelaxant effects of nicorandil in isolated piglet pulmonary and mesenteric arteries: relative efficacy and interactions between both pathways.
Topics: Animals; Cromakalim; Cyclic GMP; Enzyme Activation; Enzyme Inhibitors; Glyburide; Guanylate Cyclase; In Vitro Techniques; Male; Mesenteric Arteries; Niacinamide; Nicorandil; Nitroprusside; Potassium Channels; Pulmonary Artery; Swine; Vasodilator Agents; Verapamil | 1998 |
Potentiating effect of nicorandil on the adenosine A2 receptor-mediated vasodepression in rats: potential role for KATP channels.
Topics: Adenosine; Animals; Antihypertensive Agents; Blood Pressure; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Heart Rate; Injections, Intravenous; Male; Niacinamide; Nicorandil; Potassium Channels; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Theobromine; Vasodilator Agents | 1998 |
Beneficial hemodynamic effects of nicorandil in a canine model of acute congestive heart failure: comparison with nitroglycerin and cromakalim.
Topics: Acute Disease; Animals; Blood Pressure; Coronary Circulation; Cromakalim; Disease Models, Animal; Dogs; Female; Heart; Heart Failure; Heart Rate; Male; Myocardial Contraction; Myocardium; Niacinamide; Nicorandil; Nitroglycerin; Saponins; Vasodilator Agents | 1998 |
Potassium channel openers inhibit ATP-induced cytosolic free calcium increase in cultured rabbit aortic smooth muscle cells.
Topics: Adenosine Triphosphate; Animals; Aorta, Thoracic; Calcium; Cells, Cultured; Cromakalim; Glyburide; Muscle, Smooth, Vascular; Nicorandil; Pinacidil; Potassium Channels; Rabbits | 1996 |
Inhibitory effect of potassium channel openers on proliferation of cultured rabbit aortic smooth muscle cells.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Cell Division; Cells, Cultured; Cromakalim; Muscle, Smooth, Vascular; Nicorandil; Picolines; Pinacidil; Potassium Channels; Pyrans; Rabbits | 1996 |
Hemodynamic and hormonal responses to nicorandil in a canine model of acute ischemic heart failure: a comparison with cromakalim and nitroglycerin.
Topics: Acute Disease; Animals; Atrial Natriuretic Factor; Cardiac Output, Low; Cromakalim; Dogs; Embolization, Therapeutic; Female; Hemodynamics; Hormones; Male; Microspheres; Myocardial Ischemia; Natriuretic Peptide, Brain; Nicorandil; Nitroglycerin; Potassium Channels; Renin; Vasodilator Agents | 1999 |
Dispersion-based reentry: mechanism of initiation of ventricular tachycardia in isolated rabbit hearts.
Topics: Animals; Anisotropy; Anti-Arrhythmia Agents; Cromakalim; Heart; Heart Conduction System; In Vitro Techniques; Nicorandil; Rabbits; Refractory Period, Electrophysiological; Tachycardia, Ventricular; Time Factors | 1999 |
Comparison of the vascular relaxant effects of ATP-dependent K+ channel openers on aorta and pulmonary artery isolated from spontaneously hypertensive and Wistar-Kyoto rats.
Topics: Adenosine Triphosphate; Aminoquinolines; Animals; Aorta, Thoracic; Apamin; Benzopyrans; Charybdotoxin; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Hypertension; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nicorandil; Nitroprusside; Norepinephrine; Picolines; Pinacidil; Potassium; Potassium Channels; Pulmonary Artery; Pyrans; Pyrrolidinones; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vasodilator Agents | 1999 |
Effects of nicorandil as compared to mixtures of sodium nitroprusside and levcromakalim in isolated rat aorta.
Topics: Animals; Aorta; Cromakalim; Cyclic GMP; Glyburide; In Vitro Techniques; Male; Nicorandil; Nitroprusside; Norepinephrine; Potassium Chloride; Rats; Rats, Wistar; Vasoconstriction; Vasodilator Agents | 1999 |
Effects of the new potassium channel opener JTV-506 on coronary vessels in vitro and in vivo.
Topics: Anesthesia; Animals; Chromans; Coronary Circulation; Coronary Vessels; Cromakalim; Dogs; Female; In Vitro Techniques; Male; Nicorandil; Nifedipine; Nitroglycerin; Potassium Channels; Swine; Vasodilator Agents | 1999 |
Increase in the vasorelaxant potency of K(ATP) channel opening drugs by adenosine A(1) and A(2) receptors in the pig coronary artery.
Topics: Adenosine; Animals; ATP-Binding Cassette Transporters; Coronary Vessels; Cromakalim; Dose-Response Relationship, Drug; Drug Interactions; In Vitro Techniques; KATP Channels; Nicorandil; Phenethylamines; Pinacidil; Potassium Channels; Potassium Channels, Inwardly Rectifying; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Swine; Triazines; Triazoles; Vasodilator Agents; Xanthines | 1999 |
Antinociceptive action of epidural K+(ATP) channel openers via interaction with morphine and an alpha(2)- adrenergic agonist in rats.
Topics: Adenosine Triphosphate; Adrenergic alpha-Agonists; Analgesia; Analgesics, Opioid; Anesthetics, Combined; Animals; Cromakalim; Dexmedetomidine; Drug Interactions; Drug Synergism; Glyburide; Injections, Epidural; Ion Channel Gating; Male; Morphine; Naloxone; Narcotic Antagonists; Nicorandil; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Sprague-Dawley | 2000 |
Systemic and coronary hemodynamic effects of JTV-506, a novel potassium channel opener, in conscious dogs: comparison with cromakalim and nicorandil.
Topics: Animals; Chromans; Cromakalim; Dogs; Female; Hemodynamics; Male; Nicorandil; Potassium Channels; Vasodilator Agents | 1999 |
Block of cardiac ATP-sensitive K(+) channels reduces hydroxyl radicals in the rat myocardium.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Cromakalim; Decanoic Acids; Dose-Response Relationship, Drug; Ferrous Compounds; Glyburide; Hydroxy Acids; Hydroxybenzoates; Hydroxyl Radical; Hypoglycemic Agents; Inhibitory Concentration 50; Iron Chelating Agents; Male; Microdialysis; Myocardial Ischemia; Myocardium; Nicorandil; Potassium Channel Blockers; Rats; Rats, Wistar; Salicylates; Time Factors | 2000 |
Nicorandil stimulates release of adenyl purines from porcine coronary artery.
Topics: Adenine Nucleotides; Adenosine; Adenosine Triphosphate; Animals; Cells, Cultured; Coronary Vessels; Cromakalim; Endothelium, Vascular; In Vitro Techniques; Nicorandil; Nitric Oxide Donors; Penicillamine; Secretory Rate; Stimulation, Chemical; Swine; Vasodilator Agents | 2000 |
Guanylate cyclase and not ATP-dependent K(+) channels seems temperature-dependent in smooth muscle relaxation of human umbilical arteries.
Topics: Adenosine Triphosphate; Arginine; Cromakalim; Dose-Response Relationship, Drug; Female; Glyburide; Guanylate Cyclase; Humans; In Vitro Techniques; Molsidomine; Muscle, Smooth, Vascular; Nicorandil; Nitroarginine; Oxadiazoles; Potassium Channels; Pregnancy; Quinoxalines; Serotonin; Temperature; Umbilical Arteries; Vasodilation; Vasodilator Agents | 2000 |
The molecular basis of the specificity of action of K(ATP) channel openers.
Topics: Amino Acid Sequence; Animals; ATP-Binding Cassette Transporters; Cell Membrane; Cricetinae; Cromakalim; Diazoxide; Ion Channel Gating; Mice; Models, Molecular; Molecular Sequence Data; Muscle, Skeletal; Mutagenesis, Site-Directed; Neurons; Nicorandil; Oocytes; Pancreas; Pinacidil; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protein Isoforms; Protein Structure, Secondary; Rats; Receptors, Drug; Recombinant Fusion Proteins; Sulfonylurea Receptors | 2000 |
Role of mitochondrial and sarcolemmal K(ATP) channels in ischemic preconditioning of the canine heart.
Topics: Adenosine Triphosphate; Animals; Calcium Channel Blockers; Collateral Circulation; Coronary Circulation; Cromakalim; Decanoic Acids; Diazoxide; Dogs; Heart; Hemodynamics; Hydroxy Acids; In Vitro Techniques; Ischemic Preconditioning, Myocardial; Mitochondria, Heart; Myocardial Infarction; Myocardial Reperfusion Injury; Nicorandil; Potassium Channel Blockers; Potassium Channels; Sarcolemma; Vasodilator Agents | 2001 |
Effect of mild hypothermia on nicorandil-induced vasodilation of pial arterioles in cats.
Topics: Administration, Topical; Animals; Cats; Cerebral Arteries; Cromakalim; Dose-Response Relationship, Drug; Hemodynamics; Hypothermia; Nicorandil; Nitroglycerin; Vasodilation; Vasodilator Agents | 2001 |
Vasorelaxant properties of isolated human radial arteries: comparison with internal mammary arteries.
Topics: Adult; Aged; Calcium Channel Blockers; Coronary Artery Bypass; Cromakalim; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Mammary Arteries; Middle Aged; Nicorandil; Nitroprusside; Phenylephrine; Potassium Chloride; Radial Artery; Vasoconstriction; Vasodilation; Vasodilator Agents | 2002 |
Mitochondrial K ATP channel activation is important in the antiarrhythmic and cardioprotective effects of non-hypotensive doses of nicorandil and cromakalim during ischemia/reperfusion: a study in an intact anesthetized rabbit model.
Topics: Analysis of Variance; Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Arrhythmias, Cardiac; Blood Pressure; Cromakalim; Decanoic Acids; Disease Models, Animal; Glutathione; Heart Rate; Hydroxy Acids; Male; Malondialdehyde; Membrane Proteins; Myocardial Infarction; Myocardial Reperfusion Injury; Nicorandil; Oxidative Stress; Potassium Channels; Rabbits; Sarcolemma; Sulfonamides; Superoxide Dismutase; Survival Rate; Thiourea | 2003 |
Diazoxide induces delayed pre-conditioning in cultured rat cortical neurons.
Topics: Animals; Cell Death; Cell Hypoxia; Cell Survival; Cells, Cultured; Cerebral Cortex; Cromakalim; Decanoic Acids; Diazoxide; Enzyme Activation; Enzyme Inhibitors; Glucose; Glyburide; Hydroxy Acids; Ischemic Preconditioning; Mitochondria; Neurons; Neuroprotective Agents; Nicorandil; Nitro Compounds; Oxidative Stress; Propionates; Rats; Rats, Wistar; Succinate Dehydrogenase; Superoxides; Time Factors | 2003 |
The role of ATP-sensitive potassium channel on acute urinary retention and subsequent catheterization in the rat.
Topics: Animals; Blood Circulation; Blood Pressure; Cromakalim; Dose-Response Relationship, Drug; Female; Glyburide; Ion Channel Gating; KATP Channels; Muscle Contraction; Nicorandil; Potassium Channel Blockers; Potassium Chloride; Rats; Rats, Sprague-Dawley; Urinary Bladder; Urinary Catheterization; Urinary Retention | 2010 |
Nicorandil ameliorates ischaemia-reperfusion injury in the rat kidney.
Topics: Animals; Cromakalim; DNA Damage; Ion Channel Gating; KATP Channels; Kidney; Kidney Glomerulus; Kidney Tubules, Proximal; Lipid Peroxidation; Male; Nicorandil; Oxidative Stress; Potassium Channels, Inwardly Rectifying; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2011 |
Pharmacological preconditioning of ATP-sensitive potassium channel openers on acute urinary retention-induced bladder dysfunction in the rat.
Topics: Animals; Cromakalim; Glyburide; KATP Channels; Male; Nicorandil; Rats; Rats, Sprague-Dawley; Urinary Retention | 2012 |
The relaxant action of nicorandil in bovine tracheal smooth muscle.
Topics: Animals; Cattle; Cromakalim; Enzyme Inhibitors; Glyburide; Guanylate Cyclase; In Vitro Techniques; Muscle Relaxation; Muscle, Smooth; Nicorandil; Nitroprusside; Oxadiazoles; Peptides; Quinoxalines; Trachea; Vasodilator Agents | 2012 |
Opening of ATP-sensitive K(+) (KATP) channels enhance hydroxyl radical generation induced by MPP(+) in rat striatum.
Topics: Animals; Corpus Striatum; Cromakalim; Dopamine; Dose-Response Relationship, Drug; Glyburide; Hydroxybenzoates; Hydroxyl Radical; KATP Channels; Male; Membrane Transport Modulators; Microdialysis; MPTP Poisoning; Nicorandil; Rats, Wistar | 2016 |