nicardipine and prazosin

nicardipine has been researched along with prazosin in 34 studies

Research

Studies (34)

TimeframeStudies, this research(%)All Research%
pre-19906 (17.65)18.7374
1990's8 (23.53)18.2507
2000's11 (32.35)29.6817
2010's9 (26.47)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Decker, N; Delgado, A; Leclerc, G; Marciniak, G; Schwartz, J; Velly, J1
Topliss, JG; Yoshida, F1
Huang, L; Humphreys, JE; Morgan, JB; Polli, JW; Serabjit-Singh, CS; Webster, LO; Wring, SA1
Doman, TN; McGovern, SL; Seidler, J; Shoichet, BK1
Caron, G; Ermondi, G; Lorenti, M1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Lombardo, F; Obach, RS; Waters, NJ1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Chen, X; Lin, X; Skolnik, S; Wang, J1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Shimizu, M; Yamawaki, S1
Ogihara, M; Sunaga, K1
Jounela, AJ; Juustila, H; Kanniainen, E; Lilja, M; Pasanen, A1
Beleslin, DB; Jovanović-Micić, D; Samardzić, R1
Kou, K; Suzuki, H1
Carver, LA; Lee, CH; Strosberg, AM1
Bolli, P; Bühler, FR; Erne, P; Kiowski, W; Müller, FB1
Freslon, JL; Giudicelli, JF; Richer, C1
Dohi, Y; Kojima, M; Sato, K; Sawada, M1
Bilello, K; Cole, F; Jaffin, J; Malcolm, D; Powell, C; Schultz, S1
Asano, M; Inagaki, O; Sudoh, K; Takenaka, T; Tanaka, H1
Ambudkar, SV; Gottesman, MM; Hrycyna, CA; Pastan, I; Ramachandra, M1
Fyhrquist, F; Metsärinne, K; Saijonmaa, O1
Hamadate, N; Koyama, T; Matsuzaki, T; Nakasone, J; Noguchi, K; Sakanashi, M1
Ambudkar, SV; Bates, SE; Robey, RW; Shukla, S1
Kitazawa, T1
Gaies, E; Klouz, A; Lakhal, M; Salouage, I; Sassi, MB; Trabelsi, S1

Reviews

1 review(s) available for nicardipine and prazosin

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

1 trial(s) available for nicardipine and prazosin

ArticleYear
Biphasic pressor responses to norepinephrine in humans.
    Clinical pharmacology and therapeutics, 1995, Volume: 58, Issue:5

    Topics: Adult; Dose-Response Relationship, Drug; Hemodynamics; Humans; Infusions, Intravenous; Male; Middle Aged; Nicardipine; Norepinephrine; Phentolamine; Prazosin; Pressoreceptors; Sympatholytics; Sympathomimetics; Vasodilator Agents

1995

Other Studies

32 other study(ies) available for nicardipine and prazosin

ArticleYear
New 1,4-dihydropyridine derivatives combining calcium antagonism and alpha-adrenolytic properties.
    Journal of medicinal chemistry, 1989, Volume: 32, Issue:6

    Topics: Animals; Aorta; Calcium Channel Blockers; Calcium Chloride; Cerebral Cortex; Chemical Phenomena; Chemistry; Coronary Vessels; Dihydropyridines; Guinea Pigs; Male; Molecular Structure; Muscle Contraction; Nitrendipine; Prazosin; Rats; Receptors, Adrenergic, alpha; Swine; Vas Deferens; Yohimbine

1989
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Rational use of in vitro P-glycoprotein assays in drug discovery.
    The Journal of pharmacology and experimental therapeutics, 2001, Volume: 299, Issue:2

    Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Chromatography, Liquid; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Humans; Mass Spectrometry; Pharmacology; Spodoptera

2001
Identification and prediction of promiscuous aggregating inhibitors among known drugs.
    Journal of medicinal chemistry, 2003, Oct-09, Volume: 46, Issue:21

    Topics: Antifungal Agents; beta-Lactamase Inhibitors; Chemical Phenomena; Chemistry, Physical; Chymotrypsin; Enzyme Inhibitors; Kinetics; Light; Malate Dehydrogenase; Models, Molecular; Molecular Conformation; Scattering, Radiation; Structure-Activity Relationship

2003
Contribution of ionization and lipophilicity to drug binding to albumin: a preliminary step toward biodistribution prediction.
    Journal of medicinal chemistry, 2004, Jul-29, Volume: 47, Issue:16

    Topics: Chromatography, Affinity; Hydrogen-Ion Concentration; Ions; Models, Molecular; Molecular Conformation; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Serum Albumin, Bovine; Ultracentrifugation

2004
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
    Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:11

    Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution

2009
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model.
    Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:2

    Topics: Adenosine; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Biological Transport; Caco-2 Cells; Chromatography, Liquid; Dibenzocycloheptenes; Diketopiperazines; Drug Discovery; Heterocyclic Compounds, 4 or More Rings; Humans; Intestinal Absorption; Mass Spectrometry; Models, Biological; Neoplasm Proteins; Pharmaceutical Preparations; Predictive Value of Tests; Propionates; Quinolines; Substrate Specificity

2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Effects of Ca2+ antagonists on NA-induced intracellular Ca2+ mobilization in rat cultured neurons.
    The Japanese journal of psychiatry and neurology, 1991, Volume: 45, Issue:1

    Topics: Animals; Calcium; Cells, Cultured; Diltiazem; Frontal Lobe; Intracellular Fluid; Neurons; Nicardipine; Norepinephrine; Prazosin; Rats; Verapamil

1991
Effects of calcium channel blockers and hydralazine on plasma glucose levels in streptozotocin-induced diabetic rats in vivo.
    Japanese journal of pharmacology, 1990, Volume: 52, Issue:3

    Topics: Animals; Blood Glucose; Blood Pressure; Calcium Channel Blockers; Catecholamines; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Hexamethonium Compounds; Hydralazine; Male; Nicardipine; Nifedipine; Phentolamine; Prazosin; Propranolol; Rats; Rats, Inbred Strains; Starvation

1990
Nicardipine in combination with other antihypertensive drugs: calcium antagonist and prazosin have no additive antihypertensive effect?
    Cor et vasa, 1990, Volume: 32, Issue:2

    Topics: Adult; Aged; Calcium Channel Blockers; Drug Interactions; Drug Therapy, Combination; Female; Humans; Hypertension; Male; Middle Aged; Nicardipine; Prazosin

1990
Nature of hypo- and hyperthermia induced by the calcium antagonist nicardipine.
    Archives internationales de physiologie et de biochimie, 1987, Volume: 95, Issue:4

    Topics: Animals; Body Temperature Regulation; Cats; Fever; Hypothermia; Injections, Intraventricular; Ion Channels; Nicardipine; Prazosin; Propranolol; Receptors, Adrenergic, alpha; Respiration; Yohimbine

1987
Electrical components contributing to the nerve-mediated contractions in the smooth muscles of the rabbit ear artery.
    The Japanese journal of physiology, 1983, Volume: 33, Issue:5

    Topics: Action Potentials; Animals; Dose-Response Relationship, Drug; Electric Stimulation; Female; Guanethidine; In Vitro Techniques; Male; Membrane Potentials; Muscle Contraction; Muscle, Smooth, Vascular; Nicardipine; Nifedipine; Phentolamine; Physical Stimulation; Prazosin; Rabbits; Sympathetic Nervous System; Tetrodotoxin; Yohimbine

1983
Antihypertensive drugs: their postural hypotensive effect and their blood pressure lowering activity in conscious normotensive rats.
    Archives internationales de pharmacodynamie et de therapie, 1983, Volume: 261, Issue:1

    Topics: Animals; Antihypertensive Agents; Blood Pressure; Captopril; Clonidine; Hydrochlorothiazide; Hypotension, Orthostatic; Male; Minoxidil; Nicardipine; Nifedipine; Nitroprusside; Pentolinium Tartrate; Phentolamine; Prazosin; Rats; Rats, Inbred Strains

1983
Use of calcium antagonists as monotherapy in the management of hypertension.
    The American journal of medicine, 1984, Aug-31, Volume: 77, Issue:2B

    Topics: Calcium; Calcium Channel Blockers; Humans; Hypertension; Nicardipine; Nifedipine; Nitroprusside; Prazosin; Renin; Vasodilation; Verapamil

1984
[Antihypertensives and the prevention of development of genetic hypertension in the hypertensive SHR rat].
    Paroi arterielle, 1980, Volume: 6, Issue:4

    Topics: Animals; Antihypertensive Agents; Atenolol; Captopril; Cardiomegaly; Dihydralazine; Dose-Response Relationship, Drug; Hydrochlorothiazide; Hypertension; Male; Nicardipine; Nifedipine; Prazosin; Rats; Rats, Inbred Strains; Time Factors; Vasodilator Agents

1980
Diaspirin crosslinked hemoglobin (DCLHb): control of pressor effect with anti-hypertensive agents.
    Artificial cells, blood substitutes, and immobilization biotechnology, 1994, Volume: 22, Issue:3

    Topics: Animals; Antihypertensive Agents; Aspirin; Blood Pressure; Blood Substitutes; Hemoglobins; Hypertension; Labetalol; Nicardipine; Nitroglycerin; Prazosin; Rats

1994
Effect of tamsulosin, a novel alpha 1-adrenoceptor antagonist, on urethral pressure profile in anaesthetized dogs.
    Journal of autonomic pharmacology, 1996, Volume: 16, Issue:3

    Topics: Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Captopril; Dogs; Dose-Response Relationship, Drug; Male; Nicardipine; Prazosin; Pressure; Prostate; Quinazolines; Sulfonamides; Tamsulosin

1996
Functional characterization of a glycine 185-to-valine substitution in human P-glycoprotein by using a vaccinia-based transient expression system.
    Molecular biology of the cell, 1996, Volume: 7, Issue:10

    Topics: 3T3 Cells; Adenosine Triphosphatases; Adenosine Triphosphate; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Bone Neoplasms; Cell Membrane; Colchicine; Drug Resistance, Multiple; Genetic Vectors; Humans; Mice; Nicardipine; Onium Compounds; Organophosphorus Compounds; Osteosarcoma; Point Mutation; Prazosin; Recombinant Fusion Proteins; Rhodamine 123; Rhodamines; Transfection; Tumor Cells, Cultured; Vaccinia virus; Verapamil; Vinblastine

1996
Carvedilol and its metabolites suppress endothelin-1 production in human endothelial cell culture.
    Blood pressure, 1997, Volume: 6, Issue:1

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Antihypertensive Agents; Ascorbic Acid; Calcium Channel Blockers; Carbazoles; Carvedilol; Cells, Cultured; Endothelin-1; Endothelium, Vascular; Humans; Metoprolol; Nicardipine; Prazosin; Probucol; Propanolamines; Propranolol; Umbilical Veins

1997
Cardiovascular effects and lethality of venom from nematocysts of the box-jellyfish Chiropsalmus quadrigatus (Habu-kurage) in anaesthetized rats.
    Toxicon : official journal of the International Society on Toxinology, 2005, Mar-15, Volume: 45, Issue:4

    Topics: Animals; Atropine; Cardiovascular System; Cnidarian Venoms; Cubozoa; Dose-Response Relationship, Drug; Heart Arrest; Hemodynamics; Male; Nicardipine; Peptides, Cyclic; Prazosin; Rats; Rats, Wistar; Temperature

2005
The calcium channel blockers, 1,4-dihydropyridines, are substrates of the multidrug resistance-linked ABC drug transporter, ABCG2.
    Biochemistry, 2006, Jul-25, Volume: 45, Issue:29

    Topics: Adenosine Triphosphate; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Azides; Calcium Channel Blockers; Cell Line; Chlorophyll; Dihydropyridines; Drug Interactions; Humans; Mitoxantrone; Neoplasm Proteins; Nicardipine; Nifedipine; Photoaffinity Labels; Prazosin

2006
Contractile signaling pathways in mouse prostate smooth muscle.
    The Prostate, 2013, Volume: 73, Issue:9

    Topics: Acetylcholine; Adrenergic alpha-Agonists; Animals; Atropine; Calcium; Calcium Channel Blockers; Cholinergic Agonists; In Vitro Techniques; Male; Mice; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Nicardipine; Norepinephrine; Prazosin; Prostate; Protein Kinase Inhibitors; Ryanodine; Signal Transduction

2013
Involvement of CYP 3A5 In the Interaction Between Tacrolimus and Nicardipine: A Case Report.
    Current drug safety, 2015, Volume: 10, Issue:3

    Topics: Antihypertensive Agents; Biotransformation; Calcium Channel Blockers; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Drug Monitoring; Drug Substitution; Humans; Hypertension; Immunosuppressive Agents; Kidney Transplantation; Male; Middle Aged; Nicardipine; Polypharmacy; Prazosin; Tacrolimus

2015