nicardipine has been researched along with prazosin in 34 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (17.65) | 18.7374 |
| 1990's | 8 (23.53) | 18.2507 |
| 2000's | 11 (32.35) | 29.6817 |
| 2010's | 9 (26.47) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Decker, N; Delgado, A; Leclerc, G; Marciniak, G; Schwartz, J; Velly, J | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Huang, L; Humphreys, JE; Morgan, JB; Polli, JW; Serabjit-Singh, CS; Webster, LO; Wring, SA | 1 |
| Doman, TN; McGovern, SL; Seidler, J; Shoichet, BK | 1 |
| Caron, G; Ermondi, G; Lorenti, M | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Chen, X; Lin, X; Skolnik, S; Wang, J | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Shimizu, M; Yamawaki, S | 1 |
| Ogihara, M; Sunaga, K | 1 |
| Jounela, AJ; Juustila, H; Kanniainen, E; Lilja, M; Pasanen, A | 1 |
| Beleslin, DB; Jovanović-Micić, D; Samardzić, R | 1 |
| Kou, K; Suzuki, H | 1 |
| Carver, LA; Lee, CH; Strosberg, AM | 1 |
| Bolli, P; Bühler, FR; Erne, P; Kiowski, W; Müller, FB | 1 |
| Freslon, JL; Giudicelli, JF; Richer, C | 1 |
| Dohi, Y; Kojima, M; Sato, K; Sawada, M | 1 |
| Bilello, K; Cole, F; Jaffin, J; Malcolm, D; Powell, C; Schultz, S | 1 |
| Asano, M; Inagaki, O; Sudoh, K; Takenaka, T; Tanaka, H | 1 |
| Ambudkar, SV; Gottesman, MM; Hrycyna, CA; Pastan, I; Ramachandra, M | 1 |
| Fyhrquist, F; Metsärinne, K; Saijonmaa, O | 1 |
| Hamadate, N; Koyama, T; Matsuzaki, T; Nakasone, J; Noguchi, K; Sakanashi, M | 1 |
| Ambudkar, SV; Bates, SE; Robey, RW; Shukla, S | 1 |
| Kitazawa, T | 1 |
| Gaies, E; Klouz, A; Lakhal, M; Salouage, I; Sassi, MB; Trabelsi, S | 1 |
1 review(s) available for nicardipine and prazosin
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
1 trial(s) available for nicardipine and prazosin
| Article | Year |
|---|---|
Biphasic pressor responses to norepinephrine in humans.
Topics: Adult; Dose-Response Relationship, Drug; Hemodynamics; Humans; Infusions, Intravenous; Male; Middle Aged; Nicardipine; Norepinephrine; Phentolamine; Prazosin; Pressoreceptors; Sympatholytics; Sympathomimetics; Vasodilator Agents | 1995 |
32 other study(ies) available for nicardipine and prazosin
| Article | Year |
|---|---|
New 1,4-dihydropyridine derivatives combining calcium antagonism and alpha-adrenolytic properties.
Topics: Animals; Aorta; Calcium Channel Blockers; Calcium Chloride; Cerebral Cortex; Chemical Phenomena; Chemistry; Coronary Vessels; Dihydropyridines; Guinea Pigs; Male; Molecular Structure; Muscle Contraction; Nitrendipine; Prazosin; Rats; Receptors, Adrenergic, alpha; Swine; Vas Deferens; Yohimbine | 1989 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Rational use of in vitro P-glycoprotein assays in drug discovery.
Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Chromatography, Liquid; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Humans; Mass Spectrometry; Pharmacology; Spodoptera | 2001 |
Identification and prediction of promiscuous aggregating inhibitors among known drugs.
Topics: Antifungal Agents; beta-Lactamase Inhibitors; Chemical Phenomena; Chemistry, Physical; Chymotrypsin; Enzyme Inhibitors; Kinetics; Light; Malate Dehydrogenase; Models, Molecular; Molecular Conformation; Scattering, Radiation; Structure-Activity Relationship | 2003 |
Contribution of ionization and lipophilicity to drug binding to albumin: a preliminary step toward biodistribution prediction.
Topics: Chromatography, Affinity; Hydrogen-Ion Concentration; Ions; Models, Molecular; Molecular Conformation; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Serum Albumin, Bovine; Ultracentrifugation | 2004 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model.
Topics: Adenosine; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Biological Transport; Caco-2 Cells; Chromatography, Liquid; Dibenzocycloheptenes; Diketopiperazines; Drug Discovery; Heterocyclic Compounds, 4 or More Rings; Humans; Intestinal Absorption; Mass Spectrometry; Models, Biological; Neoplasm Proteins; Pharmaceutical Preparations; Predictive Value of Tests; Propionates; Quinolines; Substrate Specificity | 2011 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Effects of Ca2+ antagonists on NA-induced intracellular Ca2+ mobilization in rat cultured neurons.
Topics: Animals; Calcium; Cells, Cultured; Diltiazem; Frontal Lobe; Intracellular Fluid; Neurons; Nicardipine; Norepinephrine; Prazosin; Rats; Verapamil | 1991 |
Effects of calcium channel blockers and hydralazine on plasma glucose levels in streptozotocin-induced diabetic rats in vivo.
Topics: Animals; Blood Glucose; Blood Pressure; Calcium Channel Blockers; Catecholamines; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Hexamethonium Compounds; Hydralazine; Male; Nicardipine; Nifedipine; Phentolamine; Prazosin; Propranolol; Rats; Rats, Inbred Strains; Starvation | 1990 |
Nicardipine in combination with other antihypertensive drugs: calcium antagonist and prazosin have no additive antihypertensive effect?
Topics: Adult; Aged; Calcium Channel Blockers; Drug Interactions; Drug Therapy, Combination; Female; Humans; Hypertension; Male; Middle Aged; Nicardipine; Prazosin | 1990 |
Nature of hypo- and hyperthermia induced by the calcium antagonist nicardipine.
Topics: Animals; Body Temperature Regulation; Cats; Fever; Hypothermia; Injections, Intraventricular; Ion Channels; Nicardipine; Prazosin; Propranolol; Receptors, Adrenergic, alpha; Respiration; Yohimbine | 1987 |
Electrical components contributing to the nerve-mediated contractions in the smooth muscles of the rabbit ear artery.
Topics: Action Potentials; Animals; Dose-Response Relationship, Drug; Electric Stimulation; Female; Guanethidine; In Vitro Techniques; Male; Membrane Potentials; Muscle Contraction; Muscle, Smooth, Vascular; Nicardipine; Nifedipine; Phentolamine; Physical Stimulation; Prazosin; Rabbits; Sympathetic Nervous System; Tetrodotoxin; Yohimbine | 1983 |
Antihypertensive drugs: their postural hypotensive effect and their blood pressure lowering activity in conscious normotensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Captopril; Clonidine; Hydrochlorothiazide; Hypotension, Orthostatic; Male; Minoxidil; Nicardipine; Nifedipine; Nitroprusside; Pentolinium Tartrate; Phentolamine; Prazosin; Rats; Rats, Inbred Strains | 1983 |
Use of calcium antagonists as monotherapy in the management of hypertension.
Topics: Calcium; Calcium Channel Blockers; Humans; Hypertension; Nicardipine; Nifedipine; Nitroprusside; Prazosin; Renin; Vasodilation; Verapamil | 1984 |
[Antihypertensives and the prevention of development of genetic hypertension in the hypertensive SHR rat].
Topics: Animals; Antihypertensive Agents; Atenolol; Captopril; Cardiomegaly; Dihydralazine; Dose-Response Relationship, Drug; Hydrochlorothiazide; Hypertension; Male; Nicardipine; Nifedipine; Prazosin; Rats; Rats, Inbred Strains; Time Factors; Vasodilator Agents | 1980 |
Diaspirin crosslinked hemoglobin (DCLHb): control of pressor effect with anti-hypertensive agents.
Topics: Animals; Antihypertensive Agents; Aspirin; Blood Pressure; Blood Substitutes; Hemoglobins; Hypertension; Labetalol; Nicardipine; Nitroglycerin; Prazosin; Rats | 1994 |
Effect of tamsulosin, a novel alpha 1-adrenoceptor antagonist, on urethral pressure profile in anaesthetized dogs.
Topics: Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Captopril; Dogs; Dose-Response Relationship, Drug; Male; Nicardipine; Prazosin; Pressure; Prostate; Quinazolines; Sulfonamides; Tamsulosin | 1996 |
Functional characterization of a glycine 185-to-valine substitution in human P-glycoprotein by using a vaccinia-based transient expression system.
Topics: 3T3 Cells; Adenosine Triphosphatases; Adenosine Triphosphate; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Bone Neoplasms; Cell Membrane; Colchicine; Drug Resistance, Multiple; Genetic Vectors; Humans; Mice; Nicardipine; Onium Compounds; Organophosphorus Compounds; Osteosarcoma; Point Mutation; Prazosin; Recombinant Fusion Proteins; Rhodamine 123; Rhodamines; Transfection; Tumor Cells, Cultured; Vaccinia virus; Verapamil; Vinblastine | 1996 |
Carvedilol and its metabolites suppress endothelin-1 production in human endothelial cell culture.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Antihypertensive Agents; Ascorbic Acid; Calcium Channel Blockers; Carbazoles; Carvedilol; Cells, Cultured; Endothelin-1; Endothelium, Vascular; Humans; Metoprolol; Nicardipine; Prazosin; Probucol; Propanolamines; Propranolol; Umbilical Veins | 1997 |
Cardiovascular effects and lethality of venom from nematocysts of the box-jellyfish Chiropsalmus quadrigatus (Habu-kurage) in anaesthetized rats.
Topics: Animals; Atropine; Cardiovascular System; Cnidarian Venoms; Cubozoa; Dose-Response Relationship, Drug; Heart Arrest; Hemodynamics; Male; Nicardipine; Peptides, Cyclic; Prazosin; Rats; Rats, Wistar; Temperature | 2005 |
The calcium channel blockers, 1,4-dihydropyridines, are substrates of the multidrug resistance-linked ABC drug transporter, ABCG2.
Topics: Adenosine Triphosphate; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Azides; Calcium Channel Blockers; Cell Line; Chlorophyll; Dihydropyridines; Drug Interactions; Humans; Mitoxantrone; Neoplasm Proteins; Nicardipine; Nifedipine; Photoaffinity Labels; Prazosin | 2006 |
Contractile signaling pathways in mouse prostate smooth muscle.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Animals; Atropine; Calcium; Calcium Channel Blockers; Cholinergic Agonists; In Vitro Techniques; Male; Mice; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Nicardipine; Norepinephrine; Prazosin; Prostate; Protein Kinase Inhibitors; Ryanodine; Signal Transduction | 2013 |
Involvement of CYP 3A5 In the Interaction Between Tacrolimus and Nicardipine: A Case Report.
Topics: Antihypertensive Agents; Biotransformation; Calcium Channel Blockers; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Drug Monitoring; Drug Substitution; Humans; Hypertension; Immunosuppressive Agents; Kidney Transplantation; Male; Middle Aged; Nicardipine; Polypharmacy; Prazosin; Tacrolimus | 2015 |