nicardipine has been researched along with metoprolol in 28 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (7.14) | 18.7374 |
| 1990's | 8 (28.57) | 18.2507 |
| 2000's | 11 (39.29) | 29.6817 |
| 2010's | 7 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Topliss, JG; Yoshida, F | 1 |
| Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P | 1 |
| Jolivette, LJ; Ward, KW | 1 |
| Jolivette, LJ; Nagilla, R; Ward, KW | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Artursson, P; Mateus, A; Matsson, P | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Andriani, A; Bonfantino, MV; De Cesaris, R; Dentamaro, M; Filitti, V; Ranieri, G | 1 |
| Hoshino, T; Ohmae, M; Sakai, A | 1 |
| Frais, MA; Jackson, N; Reynolds, G; Silke, B; Taylor, SH; Verma, SP | 1 |
| Hagihara, T; Kishi, Y; Matsumoto, G; Matsuo, H; Naka, K; Nanjo, K; Ohoshi, T; Sanke, T; Sasaki, H; Sowa, R | 1 |
| Asakuma, S; Iwasaki, T; Ohyanagi, M | 1 |
| Carbonne, B; Jannet, D; Milliez, J; Sebban, E | 1 |
| Fyhrquist, F; Metsärinne, K; Saijonmaa, O | 1 |
| Gan, Q; Knuepfer, MM; Mueller, PJ | 1 |
| Eisenlohr, H; Lydtin, H; Rüchardt, A | 1 |
| Fukuzawa, M; Miyaguchi, S; Nakazawa, T; Ohta, S; Qiang, X; Sakata, Y; Satoh, J; Takahashi, K; Takizawa, Y; Toyota, T | 1 |
| Decolin, D; Funck-Brentano, C; Jaillon, P; Laurent-Kenesi, MA; Poirier, JM | 1 |
| Iida, H; Iwasawa, K; Jo, T; Ma, J; Nagai, R; Nakajima, T; Omata, M | 1 |
1 review(s) available for nicardipine and metoprolol
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
3 trial(s) available for nicardipine and metoprolol
| Article | Year |
|---|---|
Haemodynamic analysis of the effects of nicardipine and metoprolol alone and in combination in coronary artery disease.
Topics: Adult; Angina Pectoris; Calcium Channel Blockers; Coronary Disease; Drug Therapy, Combination; Female; Hemodynamics; Humans; Male; Metoprolol; Middle Aged; Nicardipine; Nifedipine | 1985 |
Nicardipine versus metoprolol in the treatment of hypertension during pregnancy: a randomized comparative trial.
Topics: Adult; Birth Weight; Blood Pressure; Cesarean Section; Drug Administration Schedule; Female; Humans; Hypertension; Infant, Newborn; Metoprolol; Nicardipine; Pre-Eclampsia; Pregnancy; Pregnancy Complications, Cardiovascular; Pregnancy Outcome | 1994 |
Influence of CYP2D6-dependent metabolism on the steady-state pharmacokinetics and pharmacodynamics of metoprolol and nicardipine, alone and in combination.
Topics: Adrenergic beta-Antagonists; Adult; Blood Pressure; Calcium Channel Blockers; Cross-Over Studies; Cytochrome P-450 CYP2D6; Double-Blind Method; Drug Combinations; Drug Interactions; Female; Heart Rate; Humans; Isomerism; Male; Metoprolol; Nicardipine; Phenotype | 1993 |
24 other study(ies) available for nicardipine and metoprolol
| Article | Year |
|---|---|
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability.
Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties | 2004 |
Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure.
Topics: Algorithms; Animals; Dogs; Haplorhini; Humans; Pharmaceutical Preparations; Pharmacokinetics; Rats; Species Specificity; Tissue Distribution | 2005 |
Comparative evaluation of oral systemic exposure of 56 xenobiotics in rat, dog, monkey and human.
Topics: Administration, Oral; Animals; Area Under Curve; Dogs; Haplorhini; Humans; Models, Statistical; Rats; Software; Species Specificity; Xenobiotics | 2005 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors.
Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity | 2013 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
A high-throughput cell-based method to predict the unbound drug fraction in the brain.
Topics: Animals; Brain; Dialysis; HEK293 Cells; High-Throughput Screening Assays; Humans; Pharmaceutical Preparations; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2014 |
Comparison of the effects of nicardipine and metoprolol on lipid and glycidic metabolism in hypertensive subjects.
Topics: Aged; Blood Glucose; Female; Glucose; Humans; Hypertension; Insulin; Lipid Metabolism; Male; Metoprolol; Middle Aged; Nicardipine | 1991 |
Spontaneous resolution of a dissection of the descending aorta after medical treatment with a beta blocker and a calcium antagonist.
Topics: Aorta, Thoracic; Aortic Aneurysm; Aortic Dissection; Drug Therapy, Combination; Humans; Male; Metoprolol; Middle Aged; Nicardipine; Tomography, X-Ray Computed | 1987 |
Nicardipine may impair glucose metabolism in hypertensive diabetic patients.
Topics: Adult; Aged; Atenolol; Carteolol; Diabetes Mellitus, Type 2; Diltiazem; Enalapril; Female; Glucose; Glycated Hemoglobin; Humans; Hypertension; Male; Metoprolol; Middle Aged; Nicardipine; Propanolamines | 1994 |
The effects of antianginal drugs on energy expenditure during exercise in normal subjects.
Topics: Adrenergic beta-Antagonists; Adult; Calcium Channel Blockers; Energy Metabolism; Ethanolamines; Exercise; Humans; Isosorbide Dinitrate; Male; Metoprolol; Middle Aged; Nicardipine; Propranolol | 1995 |
Carvedilol and its metabolites suppress endothelin-1 production in human endothelial cell culture.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Antihypertensive Agents; Ascorbic Acid; Calcium Channel Blockers; Carbazoles; Carvedilol; Cells, Cultured; Endothelin-1; Endothelium, Vascular; Humans; Metoprolol; Nicardipine; Prazosin; Probucol; Propanolamines; Propranolol; Umbilical Veins | 1997 |
Mechanisms of hemodynamic responses to cocaine in conscious rats.
Topics: Adrenergic beta-Antagonists; Animals; Calcium Channels; Calcium Channels, L-Type; Cocaine; Enzyme Inhibitors; Hemodynamics; Male; Metoprolol; NG-Nitroarginine Methyl Ester; Nicardipine; Nitric Oxide; Propranolol; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta | 1998 |
[Myocardial involvement in carrier states for Duchenne muscular dystrophy. A rare cause of supraventricular arrhythmia].
Topics: Angiotensin-Converting Enzyme Inhibitors; Anti-Arrhythmia Agents; Antihypertensive Agents; Atrial Fibrillation; Creatine Kinase; Diuretics; Drug Therapy, Combination; Dystrophin; Electrocardiography; Enalapril; Female; Heart; Heart Failure; Heterozygote; Humans; Immunohistochemistry; Male; Metoprolol; Middle Aged; Muscular Dystrophies; Myocardium; Nicardipine; Pedigree; Tachycardia, Supraventricular | 1998 |
Modulation of tumor necrosis factor-alpha production with anti-hypertensive drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Amlodipine; Animals; Antihypertensive Agents; Calcium Channel Blockers; Cells, Cultured; Dihydropyridines; Diuretics; Doxazosin; Humans; Hydrochlorothiazide; Interleukin-1; Interleukin-6; Lipopolysaccharides; Male; Metoprolol; Mice; Mice, Inbred BALB C; Monocytes; Nicardipine; Nitrobenzenes; Piperazines; Sodium Chloride Symporter Inhibitors; Tumor Necrosis Factor-alpha | 2000 |
Inhibitory effects of carvedilol on calcium channels in vascular smooth muscle cells.
Topics: Adrenergic beta-Antagonists; Animals; Antihypertensive Agents; Aorta; Calcium; Calcium Channels; Calcium Signaling; Carbazoles; Carvedilol; Cell Division; Endothelin-1; Metoprolol; Muscle, Smooth, Vascular; Nicardipine; Nifedipine; Propanolamines; Rats; Vasodilator Agents; Vasopressins | 2003 |