nicardipine has been researched along with dihydropyridines in 141 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 30 (21.28) | 18.7374 |
| 1990's | 77 (54.61) | 18.2507 |
| 2000's | 25 (17.73) | 29.6817 |
| 2010's | 7 (4.96) | 24.3611 |
| 2020's | 2 (1.42) | 2.80 |
| Authors | Studies |
|---|---|
| Haruno, A; Kanda, A; Miyake, H; Nagasaka, M | 1 |
| Kobayashi, M; Niwa, M; Nozaki, M; Tsurumi, K | 1 |
| Abe, H; Ashida, T; Imanishi, M; Kawano, Y; Kimura, G; Kojima, S; Murakami, K; Sanai, T; Yoshida, K; Yoshimi, H | 1 |
| Masuda, Y; Sakai, T; Tanaka, S; Tomita, K; Yokoyama, T | 1 |
| Bergamaschi, S; Govoni, S; Grimaldi, M; Meucci, O; Schettini, G; Scorziello, A; Yasumoto, T | 1 |
| Brisac, AM; Dubray, C; Huguet, F; Roche, A | 1 |
| Nishikawa, M; Okamura, T; Toda, N; Yoshida, K | 1 |
| Akiyama, S; Fujii, R; Matsumoto, T; Mizoguchi, T; Sakoda, R; Seto, K; Shudo, N | 1 |
| Fitoussi, G; Nègre-Salvayre, A; Salvayre, R; Troly, M | 1 |
| Karasawa, A; Kubo, K; Sano, J; Shirakura, S | 1 |
| Hata, H; Hojo, M; Katayama, O; Shibata, S; Tatsumi, H; Teramoto, N | 1 |
| Aoki, K; Kishimoto, T; Naruchi, T; Okamiya, Y; Sunakawa, K; Takeshita, T; Tanabe, H | 1 |
| Somasundaram, B; Tregear, RT; Trentham, DR | 1 |
| Chen, GF; Hashitani, H; Kou, M; Kuriyama, H; Nakashima, M; Ono, H; Suzuki, H | 1 |
| Abe, H; Katada, K; Nishikibe, M; Orita, M | 1 |
| Florio, T; Grimaldi, M; Landolfi, E; Meucci, O; Schettini, G; Scorziello, A; Ventra, C | 1 |
| Clark, RB; Giles, WR; Gotoh, Y; Imaizumi, Y; Shibata, EF; Watanabe, M | 1 |
| Baldy-Moulinier, M; Diochot, S; Nargeot, J; Richard, S; Valmier, J | 1 |
| Berdeaux, A; Drieu la Rochelle, C; Giudicelli, JF; Richard, V | 1 |
| Aoki, K; Kishimoto, T; Naruchi, T; Okamiya, Y; Takeshita, T; Tanabe, H | 1 |
| Dong, H; Lu, YQ; Wang, Q; Yang, QQ; Yang, ZC | 1 |
| Fujimoto, M; Mihara, S | 1 |
| Kamata, K; Kasuya, Y; Miyata, N; Nishiyama, H | 2 |
| Dohmoto, H; Goto, A; Yamada, K; Yoshimoto, R | 1 |
| Koike, H; Miyamoto, M; Oizumi, K | 2 |
| Ferry, DR; Glossmann, H; Goll, A | 1 |
| Hardman, HF; Preuss, KC; Shimshak, TM; Warltier, DC; Wynsen, JC | 1 |
| Brisac, AM; Champeroux, P; Gerard, P; Huguet, F; Laurent, S; Lucet, B; Montastruc, JL; Narcisse, G; Schmitt, H | 1 |
| Florio, T; Grimaldi, M; Landolfi, E; Magri, G; Meucci, O; Schettini, G; Yasumoto, T | 1 |
| D'Orleans-Juste, P; De Nucci, G; Vane, JR | 1 |
| Briand, V; Laurent, S; Schmitt, H | 1 |
| Kanazawa, I; Kimura, S; Masaki, T; Uchiyama, Y; Yanagisawa, M; Yoshizawa, T | 1 |
| Doussau, MP; Giudicelli, JF; Mulder, P; Richer, C | 1 |
| Ehrhardt, JD; Quennedey, MC; Rouot, B; Schwartz, J; Welsch, M | 1 |
| Watkins, WD; Whorton, AR; Xuan, YT | 1 |
| Adamson, P; Brammer, MJ; Campbell, IC; Hajimohamadreza, I | 1 |
| Nakajima, S; Ninomiya, M; Tani, T; Ueda, M | 1 |
| Hisaki, K; Matsumura, Y; Morimoto, S; Ohyama, T | 1 |
| Nagaoka, A; Shibota, M | 1 |
| Safa, AR; Spearman, T; Van Dyke, K; Ye, ZG | 1 |
| Kamei, K; Nishikibe, M; Tsuchida, S | 1 |
| Kamei, K; Nagura, J; Nishikibe, M; Suzuki, K | 1 |
| Hamajo, K; Nagaoka, A; Shibota, M | 1 |
| Hidaka, H; Matsushima, S; Saitoh, M; Tanaka, T; Watanabe, M | 1 |
| Hidaka, H; Nunoki, K; Taira, N; Tanaka, T; Umekawa, H; Yamakawa, K | 1 |
| Florio, T; Grimaldi, M; Landolfi, E; Magri, G; Meucci, O; Schettini, G | 1 |
| Brisac, AM; Champeroux, P; Laurent, S; Schmitt, H | 1 |
| Chhabra, A; Fairhurst, AS; Thayer, SA; Welcome, M | 1 |
| Dubur, GJ; Gendvilienè, VI; Kimenis, AA; Macianskiene, RA; Narusevicius, EV; Selga, MJ; Simkhovich, BZ; Velena, AH; Vitolina, RO; Zarinsh, GV | 1 |
| Barlier, S; Colin, DA; Couraud, F; Dayanithi, G; Kretz-Zaepfel, M; Martin-Moutot, N; Nordmann, JJ | 1 |
| Nakajima, A; Nishikibe, M | 1 |
| Kakeya, N; Kanda, M; Matsui, H; Morishita, S; Osumi, S; Usui, H; Wada, K | 1 |
| Imai, H; Imai, S; Matsui, K; Nakagawa, Y; Nakazawa, M; Ochi, S | 1 |
| Aihara, H; Kaneko, K; Tsuchida, K; Yamazaki, R | 1 |
| Kass, RS; Sanguinetti, MC | 1 |
| Brooker, G; Carlson, RO; Masco, D; Spiegel, S | 1 |
| Furuichi, H; Ito, S; Izumi, J; Kurimoto, T; Matsumura, T; Mori, T; Nishi, N; Suda, H; Takei, M; Tanaka, Y | 1 |
| Fukata, F; Kanda, M; Kurahashi, K; Matsui, H; Nakamura, S; Shirahase, H; Wada, K | 1 |
| Kasuya, Y; Masuda, Y; Miyajima, M; Shigenobu, K; Shudo, C; Tanaka, S | 1 |
| Kato, H; Ozaki, S; Suzuki, S; Takata, Y; Uegomori, T | 1 |
| Arimura, T; Kobayashi, K; Okada, T; Piccolino, M; Tachibana, M | 1 |
| Nargeot, J; Neveu, D; Richard, S | 1 |
| Kasuya, Y; Masuda, Y; Sakai, T; Tanaka, S; Yamashita, T | 1 |
| Heshikiri, M; Kimura, R; Ohkura, T; Shirahase, H; Uchida, S; Yamada, S; Yoshimi, A | 1 |
| Fukata, F; Kanda, M; Matsui, H; Morishita, S; Nakamura, S; Shirahase, H; Wada, K | 1 |
| Bockaert, J; Bossu, JL; Fagni, L | 1 |
| Drieu la Rochelle, CD; Grosset, A; O'Connor, SE | 1 |
| Hashizume, Y; Ishimitsu, T; Kanda, M; Nakamura, S; Shimaji, H; Shirahase, H; Uehara, Y; Wada, K | 1 |
| Adachi, I; Gemba, T; Ito, H; Kawakami, M; Masui, M; Matsunaga, K; Nakano, A; Ninomiya, M; Torii, M; Ueda, M | 1 |
| Dubray, C; Francheteau, P; Guerret, M; Merdjan, H; Steimer, JL | 1 |
| Amenta, F; Ferrante, F | 1 |
| Kocmur, L; Zorec, R | 1 |
| Karasawa, A; Kubo, K; Shirakura, S | 1 |
| Kase, N; Ohnishi, H; Yamura, T | 1 |
| Hayashi, K; Kido, H; Shinyama, H; Uchida, T; Watanabe, M | 1 |
| Kasuya, Y; Masuda, Y; Sakai, T; Shigenobu, K; Shudo, C; Tanaka, S | 1 |
| Kitahara, M; Saito, Y; Sakashita, M; Tanaka, S; Toyoda, K; Yamashita, T | 1 |
| Dozen, M; Hayashi, Y; Hosono, M; Watanabe, K | 1 |
| Fukata, F; Kanda, M; Matsui, H; Nakamura, S; Shirahase, H; Wada, K | 1 |
| Choudhury, Q; Flower, RJ; Willmott, NJ | 1 |
| Furukawa, S; Hayashi, K; Hirata, H; Masuda, Y; Shikada, K; Shudo, C; Sugita, H; Tamura, T; Tanaka, S; Tomita, K | 1 |
| Akada, Y; Funato, H; Katsuki, Y; Kawano, H; Sato, M; Uemura, A; Yano, T | 1 |
| Kikuchi, K; Sugawara, H; Tobise, K | 1 |
| Chapey, C; Hu, YP; Robert, J | 1 |
| Amenta, F; Liu, A; Sabbatini, M | 1 |
| Sharma, RK; Wang, JH; Wu, Z | 1 |
| Ebisu, H; Egi, Y; Fujino, Y; Hayashi, K; Inoue, S; Kido, H; Kubo, Y; Nakamura, N; Nishikawa, M; Ohtaki, Y; Uchida, T; Yamanaga, K | 1 |
| Kobayashi, Y; Watanabe, N; Yamashiro, T | 1 |
| Aldunate, J; Bollo-Dragnic, S; Letelier, ME; Morello, A; Núñez-Vergara, LJ; Repetto, Y; Squella, JA | 1 |
| Matsuoka, T; Nishizaki, T; Nomura, T | 1 |
| Akada, Y; Funato, H; Katsuki, Y; Kawano, H; Sato, M; Uemura, A | 1 |
| Kim, SJ; Park, YS; Sung, JJ | 1 |
| Kagitani, Y; Kawamura, T; Nagai, H; Nakamura, N; Narita, Y; Shinyama, H | 1 |
| Futamura, Y; Hamada, Y | 1 |
| Gohda, M; Kido, H; Matzno, S; Nakamura, N; Nishikawa, M; Shinyama, H; Yamanaga, K | 1 |
| Garrigos, M; Orlowski, S; Pascaud, C | 1 |
| Dohi, Y; Kojima, M; Miyagawa, K; Sato, K | 1 |
| Strichartz, GR; Xiong, Z | 1 |
| Kobayashi, Y; Koga, C; Tsuruo, T; Watanabe, N; Yamashiro, T; Yokoyama, KK | 1 |
| Fujii, Y; Kamibayashi, M; Miyazaki, H; Nagashima, K; Nomura, Y; Okuma, Y; Shimizu, K; Tanaka, S; Uehara, T | 1 |
| Gao, X; Gillman, MW; Goldman, L; Hertzmark, E; McLaughlin, TJ; Ross-Degnan, D; Soumerai, SB; Spiegelman, D | 1 |
| Bisenieks, E; Briede, J; Daija, D; Duburs, G; Makarova, N; Poikans, J; Uldriķis, J | 1 |
| Funato, H; Uemura, A; Watanabe, M | 1 |
| Christians, T; Diewald, D; Holzgrabe, U; Lehmann, J; Otte, Y; Wessler, C | 1 |
| Matsuda, Y; Tsukuda, E | 1 |
| Amenta, F; Leonardi, A; Sabbatini, M; Testa, R; Vitaioli, L | 1 |
| Poelaert, J; Roosens, C | 1 |
| Masumiya, H; Matsuda, T; Shigenobu, K; Tanaka, H; Tanaka, Y | 1 |
| Fukuzawa, M; Miyaguchi, S; Nakazawa, T; Ohta, S; Qiang, X; Sakata, Y; Satoh, J; Takahashi, K; Takizawa, Y; Toyota, T | 1 |
| Esashi, A; Fujii, S; Hosono, M; Hozumi, S; Kisara, K; Kitamura, K; Murakami, M; Nakagawasai, O; Okamura, T; Sasano, H; Suzuki, T; Tadano, T; Tan-no, K; Taniguchi, R; Yanagisawa, T | 1 |
| Hayashi, K; Matsumura, Y; Ohmagari, M; Tamai, I; Yamasaki, T | 1 |
| Jacobson, KA; Kim, YC; King, BF | 1 |
| Burley, JR; Dolphin, AC | 1 |
| Amenta, F; Baldoni, E; Sabbatini, M; Vitaioli, L | 1 |
| Araki, H; Futagami, K; Gomita, Y; Kawasaki, H; Kurosaki, Y; Nakatsuma, A | 1 |
| Cathala, L; Chesnoy-Marchais, D | 1 |
| Boschi, D; Caron, G; Di Stilo, A; Fruttero, R; Gasco, A; Rolando, B; Visentin, S | 1 |
| Blott, E; Callaghan, R; Gabriel, M; Higgins, CF; Linton, KJ; Martin, C; Soceneantu, L; Storm, J; Taylor, AM; Woodhouse, J | 1 |
| Amenta, F; Leonardi, A; Sabbatini, M; Testa, R; Tomassoni, D; Vitaioli, L | 1 |
| Bollo, S; Bontá, M; Caballero, E; Maya, JD; Medarde, M; Morello, A; Núñez-Vergara, LJ; Puebla, P; Repetto, Y; Rodriguez, A; San Feliciano, A; Squella, JA; Tellez, R; Zelada, U | 1 |
| Masuyama, Y; Nishio, I; Tsuda, K; Tsuda, S | 1 |
| Ando, K; Hashimoto, K; Nakamura, Y; Satoh, Y; Sugiyama, A; Takahara, A | 1 |
| Eto, T; Kita, T; Kitamura, K; Suzuki, Y | 1 |
| Ambudkar, SV; Bates, SE; Robey, RW; Shukla, S | 1 |
| Nakamoto, M; Ohya, Y; Sakima, A; Takishita, S; Yamazato, M | 1 |
| Daitoku, K; Furukawa, K; Motomura, S; Seya, K | 1 |
| Cadirci, E; Halici, Z; Suleyman, H | 1 |
| Asano, S; Fuke, N; Ide, F; Matsuno, A; Miyawaki, S; Murakami, M; Nakaguchi, H; Sasaki, M; Tanaka, H; Tanaka, J; Uno, T | 1 |
| Feng, ZP; Hui, K; Kostelecki, W; Kwok, TC; Leen, J; Roy, PJ | 1 |
| Hasegawa, H; Iino, K; Ishida, M; Ito, H; Kosaka, T; Nakagawa, M; Watanabe, H | 1 |
| Aladejebi, O; Hockerman, GH; Lin, M | 1 |
| Ai, J; Cook, DJ; Kan, S; Kasuya, H; Macdonald, RL | 1 |
| Hosoya, T; Iida, R; Matsuba, D; Ohkido, I; Shibasaki, T; Suda, N; Suzuki, A; Tabei, I; Takeyama, H; Yokoyama, K | 1 |
| Bernard, E; Bertrand, Y; Bleyzac, N; Goutelle, S | 1 |
| Ando, K; Cao, X; Izumi-Nakaseko, H; Nakamura, Y; Saitoh, M; Sugiyama, A; Takahara, A; Wada, T; Xu, B; Zhu, B | 1 |
| Yamamura, A | 1 |
| Kume, K; Ohsawa, M; Ono, H; Suzuki, Y; Yamamoto, S | 1 |
| Davidow, A; Ekins, S; Puhl, AC | 1 |
| Alexandre, J; Chrétien, B; Decros, JB; Descamps, R; Dolladille, C; Fischer, MO; Suard, F | 1 |
2 review(s) available for nicardipine and dihydropyridines
| Article | Year |
|---|---|
Perioperative use of dihydropyridine calcium channel blockers.
Topics: Blood Pressure; Calcium Channel Blockers; Cardiovascular Diseases; Dihydropyridines; Humans; Intraoperative Complications; Nicardipine; Perioperative Care | 2000 |
Molecular Mechanism of Dihydropyridine Ca
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Signaling; Dihydropyridines; Disease Models, Animal; Disease Progression; Humans; Hypertension, Pulmonary; Molecular Targeted Therapy; Muscle, Smooth, Vascular; Nicardipine; Pulmonary Artery; Rats; Receptors, Calcium-Sensing; Up-Regulation; Vascular Remodeling; Vasoconstriction | 2016 |
3 trial(s) available for nicardipine and dihydropyridines
| Article | Year |
|---|---|
Effect of manidipine, a new calcium antagonist, on intrarenal hemodynamics in essential hypertension.
Topics: Blood Pressure; Blood Proteins; Calcium Channel Blockers; Dihydropyridines; Female; Glomerular Filtration Rate; Hematocrit; Humans; Hypertension; Kidney; Male; Middle Aged; Nicardipine; Nitrobenzenes; Piperazines; Renal Circulation; Sodium; Sodium, Dietary | 1992 |
Long-term anti-hypertensive therapy with benidipine improves arterial stiffness over blood pressure lowering.
Topics: Adult; Antihypertensive Agents; Arteries; Blood Pressure; Calcium Channel Blockers; Diabetes Complications; Dihydropyridines; Hemodynamics; Humans; Hypertension; Male; Middle Aged; Nicardipine; Pulse; Regression Analysis | 2005 |
Cardioprotective effect of an L/N-type calcium channel blocker in patients with hypertensive heart disease.
Topics: Adult; Aged; Calcium Channel Blockers; Dihydropyridines; Female; Heart; Humans; Hypertension; Hypertrophy, Left Ventricular; Male; Middle Aged; Nicardipine; Prospective Studies; Sympathetic Nervous System; Tomography, Emission-Computed, Single-Photon; Ventricular Function, Left | 2009 |
136 other study(ies) available for nicardipine and dihydropyridines
| Article | Year |
|---|---|
Antihypertensive effects of MPC-1304, a novel calcium antagonist, in experimental hypertensive rats and dogs.
Topics: Administration, Oral; Animals; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Coronary Circulation; Dihydropyridines; Dogs; Heart Rate; Hypertension; Hypertension, Renal; Nicardipine; Nifedipine; Nisoldipine; Nitrendipine; Rats; Rats, Inbred SHR; Rats, Wistar | 1992 |
[Affinity of Z-105 to the 1,4-dihydropyridine type calcium channel and several other receptor bindings in the central nervous system].
Topics: Animals; Calcium Channel Blockers; Dihydropyridines; Diltiazem; In Vitro Techniques; Male; Nicardipine; Nitrophenols; Organophosphorus Compounds; Radioligand Assay; Rats; Receptors, Neurotransmitter; Tritium | 1992 |
Effects of NZ-105, a new calcium antagonist, on renal function in anesthetized spontaneously hypertensive rats.
Topics: Anesthesia; Animals; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Electrolytes; Glomerular Filtration Rate; Kidney; Kidney Function Tests; Kidney Tubules; Lithium; Male; Nicardipine; Nitrophenols; Organophosphorus Compounds; Rats; Rats, Inbred SHR; Renal Circulation; Urodynamics | 1992 |
Maitotoxin-induced intracellular calcium rise in PC12 cells: involvement of dihydropyridine-sensitive and omega-conotoxin-sensitive calcium channels and phosphoinositide breakdown.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Cytosol; Dihydropyridines; Dose-Response Relationship, Drug; GTP-Binding Proteins; Marine Toxins; Nicardipine; omega-Conotoxins; Oxocins; PC12 Cells; Peptides, Cyclic; Pertussis Toxin; Phosphatidylinositols; Rats; Sodium; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1992 |
Absence of a direct coupling of a G protein to dihydropyridine binding sites in rat heart.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Binding Sites; Calcium Channels; Dihydropyridines; GTP-Binding Proteins; Heart; Male; Myocardium; Nicardipine; Nifedipine; Rats; Rats, Wistar | 1992 |
AE0047, a new dihydropyridine Ca2+ entry blocker, inhibits the responses to adrenergic nerve stimulation and substance P in dog mesenteric arteries.
Topics: Adrenergic alpha-Agonists; Animals; Calcium Channel Blockers; Cyclic GMP; Dihydropyridines; Dogs; Electric Stimulation; Female; In Vitro Techniques; Male; Mesenteric Arteries; Nicardipine; Substance P; Sympathetic Nervous System; Tritium; Vasodilation | 1992 |
Potentiation of the vincristine effect on P388 mouse leukemia cells by a newly synthesized dihydropyridine analogue, PAK-200.
Topics: Animals; Blood Pressure; Dihydropyridines; Drug Resistance; Drug Synergism; Leukemia P388; Male; Mice; Nicardipine; Vincristine | 1992 |
Comparative cytoprotective effect of dihydropyridine calcium channel blockers against the toxicity of oxidized low density lipoprotein for cultured lymphoid cells.
Topics: Calcium Channel Blockers; Cell Line; Dihydropyridines; Dose-Response Relationship, Drug; Lipid Peroxidation; Lipoproteins, LDL; Lymphocytes; Nicardipine; Nifedipine; Nimodipine; Nisoldipine | 1992 |
Protective effects of benidipine on arachidonic acid-induced acute cerebral ischemia in rats.
Topics: Animals; Arachidonic Acid; Benzoquinones; Blood-Brain Barrier; Brain Edema; Brain Ischemia; Calcium Channel Blockers; Cerebral Infarction; Dihydropyridines; Evans Blue; Lipoxygenase Inhibitors; Male; Methacrylates; Nicardipine; Rats; Rats, Inbred Strains; Thromboxane-A Synthase; Ticlopidine | 1992 |
Cardiovascular effects of the new generation calcium antagonist 3-pyridine carboxylic acid 5-[(cyclopropylamino)carbonyl]-1,4-dihydro-2,6-dimethyl-4-(2-nitropheny l) octyl ester.
Topics: Anesthesia; Animals; Calcium Channel Blockers; Coronary Circulation; Dihydropyridines; Dogs; Female; Heart Conduction System; Hemodynamics; In Vitro Techniques; Male; Nicardipine; Nifedipine; Rabbits; Vasodilator Agents | 1992 |
Antihypertensive effect of the new dihydropyridine calcium antagonist (+-)-3-(benzylmethylamino)-2,2-dimethylpropyl methyl 4-(2-fluoro-5-nitrophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedica rbo xylate hydrochloride in dogs.
Topics: Anesthesia; Animals; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Dogs; Female; Femoral Artery; Heart Rate; Hypertension, Renal; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nicardipine; Norepinephrine; Potassium Chloride | 1992 |
GTP gamma S causes contraction of skinned frog skeletal muscle via the DHP-sensitive Ca2+ channels of sealed T-tubules.
Topics: Animals; Binding Sites; Binding, Competitive; Caffeine; Calcium Channels; Dihydropyridines; Egtazic Acid; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Kinetics; Microtubules; Muscle Contraction; Nicardipine; Pertussis Toxin; Photolysis; Rana pipiens; Rana temporaria; Virulence Factors, Bordetella | 1991 |
Actions of FRC-8653 on smooth muscle cells of the rabbit mesenteric artery.
Topics: Animals; Antihypertensive Agents; Biomechanical Phenomena; Calcium Channel Blockers; Dihydropyridines; Electric Stimulation; Endothelium, Vascular; Male; Membrane Potentials; Mesenteric Arteries; Muscle, Smooth, Vascular; Nicardipine; Rabbits; Sympathetic Nervous System; Synaptic Transmission | 1991 |
Effects of calcium antagonists on the erythrocyte membrane.
Topics: Animals; Calcium Channel Blockers; Dihydropyridines; Erythrocyte Membrane; Hemolysis; Male; Microscopy, Electron, Scanning; Nicardipine; Nimodipine; Rats; Rats, Inbred Strains | 1991 |
Dihydropyridine modulation of voltage-activated calcium channels in PC12 cells: effect of pertussis toxin pretreatment.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenal Gland Neoplasms; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Electrophysiology; Nicardipine; Pertussis Toxin; Pheochromocytoma; Potassium; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1991 |
Inhibition of transient outward K+ current by DHP Ca2+ antagonists and agonists in rabbit cardiac myocytes.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Blockers; Dihydropyridines; Dose-Response Relationship, Drug; Electrophysiology; Heart; In Vitro Techniques; Myocardium; Nicardipine; Potassium; Rabbits | 1991 |
Inhibition of T-type calcium currents by dihydropyridines in mouse embryonic dorsal root ganglion neurons.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Dihydropyridines; Electric Conductivity; Electric Stimulation; Electrophysiology; Ganglia, Spinal; Mice; Neurons; Nicardipine | 1991 |
Coronary effects of a combined beta adrenoceptor blocking and calcium antagonist therapy in running dogs.
Topics: Adrenergic beta-Antagonists; Animals; Atenolol; Calcium Channel Blockers; Coronary Vessels; Dihydropyridines; Dogs; Hemodynamics; Nicardipine; Nitrophenols; Running | 1991 |
Effect of TC-81, a new dihydropyridine derivative, on K(+)-induced contraction in rat aorta.
Topics: Animals; Aorta; Calcium; Calcium Radioisotopes; Dihydropyridines; Diltiazem; In Vitro Techniques; Isometric Contraction; Male; Nicardipine; Nifedipine; Papaverine; Potassium; Rats; Rats, Inbred Strains; Vasoconstriction; Vasodilator Agents | 1991 |
Antagonistic effects of dihydropyridines and verapamil on CaCl2 and 5-HT-evoked contraction in porcine coronary artery.
Topics: Animals; Calcium Chloride; Coronary Vessels; Dihydropyridines; Felodipine; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Nicardipine; Nifedipine; Nimodipine; Serotonin Antagonists; Swine; Verapamil | 1991 |
Effect of S-312, a new calcium channel blocker, on the 1,4-dihydropyridine binding sites in porcine basilar blood vessels and rat aortic smooth muscle cells.
Topics: Animals; Aorta; Basilar Artery; Binding Sites; Calcium; Calcium Channel Blockers; Cells, Cultured; Dihydropyridines; Isradipine; Muscle, Smooth, Vascular; Nicardipine; Nitrendipine; Oxadiazoles; Rats; Swine | 1991 |
Effects of CD-349, a dihydropyridine derivative, on contraction induced by vasoactive agents in canine basilar artery after subarachnoid hemorrhage.
Topics: Animals; Basilar Artery; Calcium; Dihydropyridines; Dogs; Endothelium, Vascular; In Vitro Techniques; Male; Methylene Blue; Nicardipine; Potassium; Serotonin; Subarachnoid Hemorrhage; Tetradecanoylphorbol Acetate; Vasoconstriction | 1991 |
Prolonged inhibition of vascular contraction and calcium influx by the novel 1,4-dihydropyridine calcium antagonist cinaldipine (FRC-8653).
Topics: Animals; Antihypertensive Agents; Calcium; Calcium Channel Blockers; Dihydropyridines; In Vitro Techniques; Male; Mesenteric Arteries; Muscle, Smooth, Vascular; Nicardipine; Nifedipine; Rats; Rats, Inbred Strains; Time Factors; Vasodilator Agents | 1991 |
Changes in responsiveness of the canine basilar artery to endothelin-1 after subarachnoid hemorrhage.
Topics: Animals; Basilar Artery; Calcium; Calcium Channel Blockers; Dihydropyridines; Dogs; Endothelins; In Vitro Techniques; Male; Muscle Contraction; Nicardipine; Subarachnoid Hemorrhage; Tetradecanoylphorbol Acetate | 1991 |
Antihypertensive effect of CS-905, a novel dihydropyridine calcium blocker, in conscious hypertensive dogs.
Topics: Animals; Antihypertensive Agents; Azetidinecarboxylic Acid; Azetines; Calcium Channel Blockers; Dihydropyridines; Dogs; Dose-Response Relationship, Drug; Hypertension, Renal; Juxtaglomerular Apparatus; Male; Nephrectomy; Nicardipine; Renin; Renin-Angiotensin System | 1990 |
Photoaffinity labelling of the cardiac calcium channel. (-)-[3H]azidopine labels a 165 kDa polypeptide, and evidence against a [3H]-1,4-dihydropyridine-isothiocyanate being a calcium-channel-specific affinity ligand.
Topics: Affinity Labels; Animals; Azides; Calcium; Cell Membrane; Dihydropyridines; Electrophoresis, Polyacrylamide Gel; Guinea Pigs; Heart; Hexobendine; Ion Channels; Isothiocyanates; Myocardium; Nicardipine; Nifedipine; Peptides; Pyridines; Rats; Species Specificity; Thiocyanates | 1987 |
Cardiovascular actions of a new dihydropyridine calcium antagonist, 8363-S: comparison with nifedipine and nicardipine in awake, unsedated dogs.
Topics: Administration, Oral; Animals; Calcium Channel Blockers; Cardiovascular System; Dihydropyridines; Dogs; Dose-Response Relationship, Drug; Hemodynamics; Injections, Intravenous; Nicardipine; Nifedipine; Pyridines | 1987 |
Central interactions between dihydropyridines and cholinergic systems in the control of blood pressure in rat.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Acetylcholine; Animals; Atropine Derivatives; Blood Pressure; Cerebral Ventricles; Dihydropyridines; Hemicholinium 3; Hexamethonium; Hexamethonium Compounds; Hippocampus; In Vitro Techniques; Male; Nicardipine; Potassium; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Reference Values; Species Specificity | 1987 |
Pertussis toxin pretreatment abolishes dihydropyridine inhibition of calcium flux in the 235-1 pituitary cell line.
Topics: Animals; Calcium; Dihydropyridines; Ion Channels; Marine Toxins; Nicardipine; Oxocins; Pertussis Toxin; Pituitary Neoplasms; Prolactin; Tumor Cells, Cultured; Verapamil; Virulence Factors, Bordetella | 1988 |
Endothelin-1 contracts isolated vessels independently of dihydropyridine-sensitive Ca2+ channel activation.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Agonists; Calcium Channels; Captopril; Dihydropyridines; Dogs; Endothelins; In Vitro Techniques; Male; Methylene Blue; Muscle Contraction; Muscle, Smooth, Vascular; Nicardipine; Peptides; Rabbits | 1989 |
Interaction between isoproterenol and dihydropyridines in heart cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Cells, Cultured; Chick Embryo; Dihydropyridines; Heart; Isoproterenol; Myocardial Contraction; Myocardium; Nicardipine; Nifedipine; Time Factors | 1989 |
Endothelin localizes in the dorsal horn and acts on the spinal neurones: possible involvement of dihydropyridine-sensitive calcium channels and substance P release.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Dose-Response Relationship, Drug; Endothelins; Immunohistochemistry; In Vitro Techniques; Neurons; Nicardipine; Peptides; Rats; Rats, Inbred Strains; Spinal Cord; Substance P; Swine; Vasoconstrictor Agents | 1989 |
[Potassium agonists: regional vasodilator profile in rats].
Topics: Animals; Benzopyrans; Cromakalim; Dihydropyridines; Hemodynamics; Male; Nicardipine; Pyrroles; Rats; Rats, Inbred Strains; Vasodilator Agents | 1989 |
Improved radioreceptor assay for the determination of plasma levels of dihydropyridine calcium channel blockers in humans.
Topics: Animals; Calcium Channel Blockers; Dihydropyridines; Isradipine; Male; Mass Spectrometry; Nicardipine; Nitrendipine; Pyridines; Radioligand Assay; Rats; Rats, Inbred Strains | 1989 |
Inhibition by nicardipine of endothelin-mediated inositol phosphate formation and Ca2+ mobilization in smooth muscle cell.
Topics: Animals; Benzofurans; Calcium Channels; Cell Line; Dihydropyridines; Endothelins; Endothelium, Vascular; Fluorescent Dyes; Fura-2; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Kinetics; Muscle, Smooth, Vascular; Nicardipine; Peptides; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Rats; Sugar Phosphates | 1989 |
Intrasynaptosomal free calcium concentration is increased by phorbol esters via a 1,4-dihydropyridine-sensitive (L-type) Ca2+ channel.
Topics: Animals; Calcium; Calcium Channels; Dihydropyridines; Fluorescent Dyes; In Vitro Techniques; Male; Nicardipine; Nifedipine; Phorbol Esters; Rats; Rats, Inbred Strains; Synaptosomes; Tetradecanoylphorbol Acetate | 1989 |
Effects of S-312, a new calcium antagonist, on the mechanical and electrophysiological responses of isolated cardiovascular preparations.
Topics: Animals; Arteries; Calcium Channel Blockers; Cecum; Dihydropyridines; Electrophysiology; Guinea Pigs; Heart; Heart Conduction System; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Myocardial Contraction; Nicardipine; Nifedipine; Rabbits; Sinoatrial Node; Vasodilation | 1989 |
Effects of CV-4093, a new dihydropyridine calcium channel blocker, on renal hemodynamics and function in stroke-prone spontaneously hypertensive rats (SHRSP).
Topics: Animals; Body Weight; Calcium Channel Blockers; Cerebrovascular Disorders; Dihydropyridines; Hemodynamics; Hypertension; Injections, Intravenous; Kidney Function Tests; Male; Nicardipine; Nitrobenzenes; Organ Size; Piperazines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Renal Circulation; Urodynamics | 1989 |
Natriuretic action of manidipine hydrochloride, a new calcium channel blocker, in spontaneously hypertensive rats.
Topics: Animals; Calcium Channel Blockers; Dihydropyridines; Electrolytes; Male; Natriuresis; Nicardipine; Nifedipine; Nitrobenzenes; Piperazines; Rats; Rats, Inbred SHR; Renal Circulation; Urodynamics | 1989 |
3H-azidopine photoaffinity labeling of high molecular weight proteins in chloroquine resistant falciparum malaria.
Topics: Affinity Labels; Animals; Azides; Binding, Competitive; Chloroquine; Chlorpromazine; Dihydropyridines; Drug Resistance; Glycoproteins; Molecular Weight; Nicardipine; Photochemistry; Plasmodium falciparum; Proteins; Quinacrine; Reserpine; Trifluoperazine; Verapamil | 1989 |
[Effects of NB-818 on a transient bilateral common carotid arteries occlusion model in Mongolian gerbils].
Topics: Animals; Arterial Occlusive Diseases; Calcium Channel Blockers; Carotid Artery Diseases; Dihydropyridines; Female; Flunarizine; Gerbillinae; Male; Nicardipine; Nimodipine | 1989 |
Effect of the newly synthetized calcium antagonist isopropyl methyl 2-carbamoyloxymethyl-6-methyl-4-(2,3-dichlorophenyl)-1,4-dihydropyridine-3,5- dicarboxylate on cerebral venous outflow in dogs.
Topics: Animals; Blood Gas Analysis; Blood Pressure; Calcium Channel Blockers; Cerebrovascular Circulation; Dihydropyridines; Dogs; Female; Heart Rate; Male; Nicardipine; Nimodipine; Oxygen Consumption; Time Factors; Vascular Resistance | 1989 |
Effects of a new dihydropyridine derivative, CV-4093.2HCl, on renal hemodynamics in spontaneously hypertensive rats.
Topics: Anesthesia; Angiotensin II; Animals; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Heart Rate; Nicardipine; Nitrobenzenes; Norepinephrine; Piperazines; Rats; Rats, Inbred SHR; Regional Blood Flow; Renal Circulation; Time Factors | 1989 |
Different sensitivities of Ca2+, calmodulin-dependent cyclic nucleotide phosphodiesterases from rabbit aorta and brain to dihydropyridine calcium channel blockers.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Aorta; Brain; Calcium Channel Blockers; Cyclic Nucleotide Phosphodiesterases, Type 1; Dihydropyridines; Enzyme Activation; In Vitro Techniques; Kinetics; Nicardipine; Nimodipine; Nucleotides, Cyclic; Phosphodiesterase Inhibitors; Rabbits | 1987 |
Inhibition of calmodulin function by CV-159, a novel dihydropyridine compound.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Calcium; Calmodulin; Cattle; Dansyl Compounds; Dihydropyridines; Myosin-Light-Chain Kinase; Nicardipine | 1988 |
Role of G-proteins in mediating dihydropyridine receptor coupling with voltage sensitive calcium channels.
Topics: Animals; Calcium Channels; Cell Line; Dihydropyridines; GTP-Binding Proteins; Marine Toxins; Nicardipine; Oxocins; Rats; Receptors, Nicotinic; Verapamil; Virulence Factors, Bordetella | 1988 |
Endogenous opiate system and dihydropyridine-induced central regulation of sympathetic tone in rats.
Topics: Animals; Blood Pressure; Dihydropyridines; Endorphins; Hydroxydopamines; Hypotension; Male; Naloxone; Nicardipine; Oxidopamine; Rats; Rats, Inbred SHR; Receptors, Opioid; Sympathetic Nervous System | 1988 |
Effects of dihydropyridine calcium channel blocking drugs on rat brain muscarinic and alpha-adrenergic receptors.
Topics: Animals; Brain; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Dioxanes; Gallopamil; In Vitro Techniques; Nicardipine; Nifedipine; Pyridines; Quinuclidinyl Benzilate; Rats; Receptors, Adrenergic, alpha; Receptors, Muscarinic; Receptors, Nicotinic; Stereoisomerism | 1985 |
Effect of ryodipine on electromechanical parameters of heart and vessels, cAMP phosphodiesterase activity and swelling-contraction cycle of mitochondria.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Anura; Calcium Channel Blockers; Cardiovascular Agents; Cattle; Dihydropyridines; Electric Stimulation; Electrophysiology; Heart; In Vitro Techniques; Mitochondria; Mitochondria, Liver; Mitochondrial Swelling; Muscle Contraction; Muscle, Smooth, Vascular; Myocardial Contraction; Nicardipine; Nifedipine; Pyridines; Rabbits; Rats | 1985 |
The calcium channel antagonist omega-conotoxin inhibits secretion from peptidergic nerve terminals.
Topics: Animals; Arginine Vasopressin; Calcium Channel Blockers; Cell Membrane; Dihydropyridines; Electric Stimulation; In Vitro Techniques; Kinetics; Male; Mollusk Venoms; Nerve Endings; Nicardipine; omega-Conotoxin GVIA; Pituitary Gland, Posterior; Potassium; Rats; Reference Values; Verapamil | 1988 |
Effects of the calcium antagonist NB-818 on cerebral blood flow.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Cerebrovascular Circulation; Dihydropyridines; Heart Rate; Macaca mulatta; Male; Nicardipine; Nimodipine; Rabbits; Reference Values; Species Specificity | 1988 |
Antihypertensive effect of NKY-722, a new water-soluble 1,4-dihydropyridine derivative, on conscious spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Dihydropyridines; Dogs; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Nicardipine; Rats; Rats, Inbred SHR | 1988 |
Effects of the new dihydropyridine derivative 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid methyl 6-(5-phenyl-3-pyrazolyloxy)hexyl ester on the cardiohemodynamics and the energy metabolism of ischemic myocardium.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Chemical Phenomena; Chemistry; Coronary Circulation; Coronary Disease; Dihydropyridines; Dogs; Dose-Response Relationship, Drug; Energy Metabolism; Esters; Female; Heart; Heart Rate; Hemodynamics; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Male; Nicardipine; Rats | 1987 |
Effects of the new calcium antagonist 2-nitratopropyl-3-nitratopropyl-2,6-dimethyl-4-(3-nitrophe nyl)- 1,4-dihydropyridine-3,5-dicarboxylate on cerebral circulation in dogs.
Topics: Animals; Basilar Artery; Calcium Channel Blockers; Cerebrovascular Circulation; Dihydropyridines; Dinoprost; Dogs; Female; Heart Rate; Hemodynamics; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nicardipine; Nimodipine; Potassium Chloride; Prostaglandins F; Serotonin | 1987 |
Voltage-dependent block of calcium channel current in the calf cardiac Purkinje fiber by dihydropyridine calcium channel antagonists.
Topics: Animals; Binding Sites; Cattle; Dihydropyridines; Electrophysiology; Heart Conduction System; Ion Channels; Membrane Potentials; Nicardipine; Nifedipine; Nisoldipine; Nitrendipine; Purkinje Fibers; Pyridines; Verapamil | 1984 |
Endogenous ganglioside GM1 modulates L-type calcium channel activity in N18 neuroblastoma cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Cell Line; Cholera Toxin; Dihydropyridines; Egtazic Acid; Fura-2; G(M1) Ganglioside; G(M3) Ganglioside; Manganese; Mice; Microscopy, Fluorescence; Neuroblastoma; Nicardipine; Nickel; Potassium; Tumor Cells, Cultured | 1994 |
[Effect of efonidipine hydrochloride, a calcium channel blocker, on the experimental cerebral ischemia/anoxia].
Topics: Animals; Brain Ischemia; Calcium Channel Blockers; Dihydropyridines; Flunarizine; Hypoxia; Male; Mice; Mice, Inbred ICR; Nicardipine; Nitrophenols; Organophosphorus Compounds; Rats; Rats, Wistar | 1995 |
Effects of the novel water-soluble calcium antagonist (+/-)-3-(4-allyl-1-piperazinyl)-2,2-dimethylpropyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate dihydrochloride on the responses of isolated canine arteries.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Arteries; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Dihydropyridines; Dogs; Female; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nicardipine; Nifedipine; Norepinephrine; Potassium Chloride; Vasoconstrictor Agents; Vasodilator Agents | 1995 |
Cardiovascular selectivity of 1,4-dihydropyridine derivatives, efonidipine (NZ-105), nicardipine and structure related compounds in isolated guinea-pig tissues.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Atrial Function; Calcium Channel Blockers; Depression, Chemical; Dihydropyridines; Guinea Pigs; Heart; Heart Atria; Heart Rate; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Myocardial Contraction; Nicardipine; Nitrophenols; Organophosphorus Compounds; Rabbits | 1995 |
Effects of benidipine hydrochloride on contractions induced by some contractile agents in isolated cerebral and mesenteric arteries of dogs.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Calcium Channel Blockers; Cerebral Arteries; Dihydropyridines; Dogs; Female; In Vitro Techniques; Male; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Nicardipine; Potassium Chloride; Prostaglandin Endoperoxides, Synthetic; Serotonin; Thromboxane A2; Vasoconstrictor Agents | 1995 |
Dihydropyridine-sensitive calcium current mediates neurotransmitter release from bipolar cells of the goldfish retina.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Fura-2; Goldfish; In Vitro Techniques; Kinetics; Neurons; Nicardipine; Nifedipine; omega-Conotoxins; Peptides; Retina | 1993 |
Two high-voltage-activated, dihydropyridine-sensitive Ca2+ channel currents with distinct electrophysiological and pharmacological properties in cultured rat aortic myocytes.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Aorta; Barium; Calcium Channels; Cell Membrane Permeability; Cells, Cultured; Dihydropyridines; Electric Conductivity; Electrophysiology; Male; Muscle, Smooth, Vascular; Nicardipine; Rats; Rats, Wistar | 1993 |
Inhibitory effect of NZ-105, a 1,4-dihydropyridine derivative, on cyclic nucleotide phosphodiesterase activity.
Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Aorta, Thoracic; Calcium Channel Blockers; Cattle; Cyclic AMP; Cyclic GMP; Dihydropyridines; In Vitro Techniques; Intracellular Fluid; Male; Myocardium; Nicardipine; Nitrophenols; Organophosphorus Compounds; Rabbits | 1993 |
The receptor occupation and plasma concentration of NKY-722, a water-soluble dihydropyridine-type calcium antagonist, in spontaneously hypertensive rats.
Topics: Administration, Oral; Animals; Aorta; Calcium Channel Blockers; Cell Membrane; Cerebral Cortex; Dihydropyridines; Dose-Response Relationship, Drug; Nicardipine; Rats; Rats, Inbred SHR | 1995 |
Antihypertensive effect of the novel water-soluble calcium antagonist (+/-)-3-(4-allyl-1-piperazinyl)-2,2-dimethylpropyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate dihydrochloride in rats.
Topics: Anesthesia; Animals; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Dose-Response Relationship, Drug; Heart Rate; Male; Nicardipine; Potassium Chloride; Rats; Rats, Inbred SHR; Rats, Wistar; Splanchnic Circulation | 1994 |
Inhibitory effects of dihydropyridines on macroscopic K+ currents and on the large-conductance Ca(2+)-activated K+ channel in cultured cerebellar granule cells.
Topics: Animals; Calcium; Cerebellum; Dihydropyridines; Dose-Response Relationship, Drug; Mice; Nicardipine; Potassium Channels; Tetraethylammonium Compounds | 1994 |
Comparison of the haemodynamic profiles of elgodipine and nicardipine in the anaesthetized dog.
Topics: Animals; Atropine; Blood Pressure; Calcium Channel Blockers; Cardiac Output; Dihydropyridines; Dogs; Electrocardiography; Female; Heart Conduction System; Heart Rate; Hemodynamics; Male; Myocardial Contraction; Nicardipine; Oxygen Consumption; Propranolol; Vascular Resistance; Vasodilation | 1994 |
Effects of dihydropyridine Ca blockers on the renal function in nephrotic spontaneously hypertensive rat (SHR).
Topics: Animals; Azetidinecarboxylic Acid; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Glomerular Filtration Rate; Heart Rate; Hypertension; Kidney Function Tests; Male; Nephrosis; Nicardipine; Puromycin Aminonucleoside; Rats; Rats, Inbred SHR; Sodium | 1994 |
Protective effect of the calcium antagonist NKY-722 against renal and arterial injuries in Dahl salt-sensitive rats.
Topics: Animals; Aorta, Thoracic; Arteries; Blood Pressure; Calcium Channel Blockers; Cerebral Arteries; Dihydropyridines; Epoprostenol; Hypertension; Kidney; Male; Nicardipine; Rats; Renal Artery; Thromboxane A2 | 1994 |
Pharmacological studies on a new dihydrothienopyridine calcium antagonist. 4th communication: prophylactic and therapeutic effects of S-(+)-methyl-4,7-dihydro-3-isobutyl-6-methyl-4-(3-nitrophenyl)thieno[2, 3- b]pyridine-5-carboxylate in stroke-prone spont
Topics: Animals; Behavior, Animal; Blood Pressure; Body Weight; Brain; Calcium Channel Blockers; Cerebrovascular Disorders; Dihydropyridines; Drinking; Eating; Heart Rate; Hypertension; Life Expectancy; Male; Nicardipine; Nimodipine; Organ Size; Rats; Rats, Inbred SHR; Sodium, Dietary | 1993 |
A mathematical model for dynamics of cardiovascular drug action: application to intravenous dihydropyridines in healthy volunteers.
Topics: Adult; Baroreflex; Blood Pressure; Cardiac Output; Cardiovascular Agents; Dihydropyridines; Heart Rate; Hemodynamics; Humans; Infusions, Intravenous; Male; Models, Theoretical; Nicardipine; Nifedipine; Pressoreceptors; Retrospective Studies; Vascular Resistance | 1993 |
Autoradiographic localization of [3H]nicardipine binding sites in the human renal artery.
Topics: Aged; Autoradiography; Binding, Competitive; Calcium Channels; Dihydropyridines; Humans; Male; Middle Aged; Muscle, Smooth, Vascular; Nicardipine; Radioligand Assay; Renal Artery | 1993 |
A new approach to separation of voltage-activated Ca currents in rat melanotrophs.
Topics: Animals; Calcium Channels; Dihydropyridines; Electric Conductivity; Electric Stimulation; Male; Melanocyte-Stimulating Hormones; Nicardipine; Nitrendipine; Pituitary Gland; Rats; Rats, Wistar | 1993 |
Effect of benidipine hydrochloride (KW-3049), on cerebral ischemia induced by bilateral occlusion of the common carotid arteries in rats.
Topics: Adenosine Triphosphate; Animals; Behavior, Animal; Brain; Brain Chemistry; Brain Ischemia; Calcium Channel Blockers; Carotid Artery, Common; Dihydropyridines; Lactates; Lactic Acid; Male; Nicardipine; Nifedipine; Phosphocreatine; Potassium; Rats; Rats, Wistar; Sodium; Verapamil | 1993 |
[Pharmacological profile of F-0401, a novel dihydropyridine derivative. (2). The vasodilator action of F-0401 in isolated canine arteries].
Topics: Animals; Arteries; Calcium Channels; Dihydropyridines; Dogs; Female; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nicardipine; Nimodipine; Potassium Chloride; Vasodilator Agents | 1993 |
Effects of AE0047 on renal haemodynamics and function in anaesthetized dogs.
Topics: Anesthesia; Animals; Calcium Channel Blockers; Dihydropyridines; Diuresis; Dogs; Hemodynamics; Infusions, Intra-Arterial; Injections, Intravenous; Kidney; Natriuresis; Nicardipine; Renal Artery | 1993 |
Studies on the hypotensive mechanisms of NZ-105, a new dihydropyridine derivative, in rats and rabbits.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Decerebrate State; Dihydropyridines; Male; Nicardipine; Nitrophenols; Organophosphorus Compounds; Posture; Rabbits; Rats; Rats, Inbred SHR; Rats, Wistar | 1993 |
Effects of efonidipine hydrochloride on cholesterol esterification mediated by beta-very low density lipoprotein in J774 macrophages.
Topics: Animals; Binding, Competitive; Calcium Channel Blockers; Cholesterol; Cyclic AMP; Dihydropyridines; Dose-Response Relationship, Drug; Esterification; Lipoproteins, VLDL; Macrophages; Mice; Nicardipine; Nitrophenols; Organophosphorus Compounds; Radioligand Assay | 1995 |
[Effect of cilnidipine on renal function in SHR and endothelin-induced renal dysfunction].
Topics: Acute Kidney Injury; Animals; Calcium Channel Blockers; Dihydropyridines; Diuresis; Endothelins; Hypertension; Male; Natriuresis; Nicardipine; Nifedipine; Rats; Rats, Inbred SHR; Renal Circulation | 1996 |
Effects of the novel water-soluble calcium antagonist (+/-)-3-(4-allyl-1-piperazinyl)-2,2-dimethylpropyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate dihydrochloride on the endothelium-independent and endothelium-dependent c
Topics: Acetylcholine; Adenosine Diphosphate; Animals; Calcium Channel Blockers; Cerebral Arteries; Dihydropyridines; Dogs; Endothelium, Vascular; Female; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nicardipine; Potassium Chloride; Serotonin | 1996 |
Functional importance of the dihydropyridine-sensitive, yet voltage-insensitive store-operated Ca2+ influx of U937 cells.
Topics: Adenosine Triphosphate; Bridged-Ring Compounds; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Cell Division; Cell Line; Dihydropyridines; Egtazic Acid; Elapid Venoms; Humans; Manganese; Monocytes; Nicardipine; Norbornanes; Thapsigargin; Thiocarbamates; Thiones | 1996 |
Effects of efonidipine, nicardipine and captopril on proteinuria in aged spontaneously hypertensive rats.
Topics: Aging; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Calcium Channel Blockers; Captopril; Creatinine; Dihydropyridines; Heart Rate; Hypertension; Kidney; Male; Nicardipine; Nitrophenols; Organophosphorus Compounds; Proteinuria; Rats; Rats, Inbred SHR | 1996 |
[Effects of lacidipine, a new dihydropyridipine derivative, on various cerebral ischemia models].
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Cerebrovascular Circulation; Dihydropyridines; Disease Models, Animal; Dogs; Ischemic Attack, Transient; Male; Nicardipine; Rats; Rats, Sprague-Dawley | 1996 |
Antioxidant effects of calcium antagonists on rat myocardial membrane lipid peroxidation.
Topics: Adenosine Diphosphate; Animals; Antioxidants; Calcium Channel Blockers; Cell Membrane; Dihydropyridines; Diltiazem; Felodipine; Fumarates; Heart; Iron; Lipid Peroxidation; Male; Myocardium; Nicardipine; Nifedipine; Nisoldipine; Nitrendipine; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Verapamil | 1996 |
Relationship between the inhibition of azidopine binding to P-glycoprotein by MDR modulators and their efficiency in restoring doxorubicin intracellular accumulation.
Topics: Affinity Labels; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Cyclosporine; Cyclosporins; Dihydropyridines; Doxorubicin; Drug Resistance, Multiple; Humans; Mice; Nicardipine; Piperidines; Triazines; Tumor Cells, Cultured; Verapamil | 1996 |
Pharmacological characterization and autoradiographic localization of dihydropyridine-type calcium channels in the kidney of spontaneously hypertensive rats.
Topics: Animals; Autoradiography; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Kidney; Kinetics; Male; Nicardipine; Radioligand Assay; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 1995 |
Mechanisms of inhibition of calmodulin-stimulated cyclic nucleotide phosphodiesterase by dihydropyridine calcium antagonists.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Binding, Competitive; Brain; Calcium; Calcium Channel Blockers; Calmodulin; Cattle; Cyclic Nucleotide Phosphodiesterases, Type 1; Dihydropyridines; Felodipine; Isoenzymes; Molecular Weight; Nicardipine; Phosphodiesterase Inhibitors | 1997 |
[Antihypertensive effects of a novel calcium antagonist, AE0047, in various hypertensive models].
Topics: Administration, Oral; Animals; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Desoxycorticosterone; Dihydropyridines; Dogs; Dose-Response Relationship, Drug; Heart Rate; Hypertension; Hypertension, Renal; Injections, Intravenous; Nicardipine; Nitrendipine; Rats; Rats, Inbred SHR | 1997 |
Reduction of intracellular pH by inhibitors of natural killer cell activity, nicardipine, methyl 2-(N-benzyl-N-methylamino)ethyl-2,6-dimethyl-4-(2-isopropyl-pyrazolo[1, 5-a]pyridine-3-yl)-1,4-dihydro-pyridine-3,5-dicarboxylate (AHC-52), and 4,4'-diisothio
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cytotoxicity, Immunologic; Dihydropyridines; Flow Cytometry; Humans; Hydrogen-Ion Concentration; Killer Cells, Natural; Nicardipine; Pyrazoles; Tumor Cells, Cultured | 1997 |
Nitro aryl 1,4-dihydropyridine derivatives: effects on Trypanosoma cruzi.
Topics: Animals; Calcium Channel Blockers; Dihydropyridines; Growth Inhibitors; Nicardipine; Nitro Compounds; Oxygen Consumption; Trypanosoma cruzi | 1997 |
The voltage-dependent non-selective cation channel sensitive to the L-type calcium channel blocker efonidipine regulates Ca2+ influx in brain vascular smooth muscle cells.
Topics: Animals; Barium; Brain; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Carotid Arteries; Cattle; Cells, Cultured; Cerebral Arteries; Dihydropyridines; Membrane Potentials; Muscle, Smooth, Vascular; Nicardipine; Nitrophenols; Organophosphorus Compounds; Patch-Clamp Techniques; Time Factors | 1997 |
Effects of a calcium antagonist, lacidipine, on experimental focal cerebral ischemia in rats.
Topics: Adenosine Triphosphate; Animals; Brain; Calcium Channel Blockers; Cerebral Arterial Diseases; Cerebral Infarction; Cerebrovascular Circulation; Dihydropyridines; Disease Models, Animal; Dose-Response Relationship, Drug; Energy Metabolism; Ischemic Attack, Transient; Male; Neurologic Examination; Nicardipine; Rats; Rats, Sprague-Dawley | 1997 |
L-type and dihydropyridine-resistant calcium channel trigger exocytosis with similar efficacy in single rat pancreatic beta cells.
Topics: Animals; Cadmium; Calcium; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Dihydropyridines; Drug Resistance; Electric Conductivity; Exocytosis; Islets of Langerhans; Nicardipine; Rats; Rats, Sprague-Dawley | 1998 |
Therapeutic effects of AE0047, a novel calcium antagonist, on progression of brain damage after stroke in stroke-prone spontaneously hypertensive rats.
Topics: Animals; Brain; Calcium Channel Blockers; Cerebrovascular Disorders; Dihydropyridines; Hydralazine; Male; Nicardipine; Rats; Rats, Inbred SHR; Vasodilator Agents | 1998 |
Induction of Leydig cell tumors by lacidipine via up-regulation of the LHRH receptor on Leydig cells in rats.
Topics: Administration, Oral; Animals; Bromodeoxyuridine; Calcium Channel Blockers; Cells, Cultured; Dihydropyridines; Leydig Cell Tumor; Leydig Cells; Luteinizing Hormone; Macaca mulatta; Male; Mice; Nicardipine; Protein Kinases; Proto-Oncogenes; Rats; Rats, Sprague-Dawley; Receptors, LHRH; Species Specificity; Testosterone; Up-Regulation | 1998 |
Calcium channel blocking and vasodilating actions of the novel dihydropyridine derivative AE0047.
Topics: Animals; Antihypertensive Agents; Aorta; Binding Sites; Binding, Competitive; Calcium; Calcium Channel Blockers; Cattle; Dihydropyridines; Dose-Response Relationship, Drug; Guinea Pigs; Heart Ventricles; Nicardipine; Nitrendipine; Patch-Clamp Techniques; Rats; Structure-Activity Relationship; Vasodilator Agents | 1998 |
Multidrug resistance transporter P-glycoprotein has distinct but interacting binding sites for cytotoxic drugs and reversing agents.
Topics: Adenosine Triphosphatases; Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Calcium Channel Blockers; CHO Cells; Cricetinae; Cytotoxins; Dihydropyridines; Drug Resistance, Multiple; Fibroblasts; Nicardipine; Nimodipine; Nitrendipine; Protein Binding; Verapamil; Vinblastine | 1998 |
Acute antihypertensive effects of calcium channel blockers are not affected by calcium supplementation in patients with essential hypertension.
Topics: Administration, Oral; Adult; Antihypertensive Agents; Blood Pressure; Calcium; Calcium Channel Blockers; Calcium, Dietary; Dihydropyridines; Drug Evaluation; Drug Therapy, Combination; Female; Heart Rate; Humans; Hypertension; Infusions, Intravenous; Male; Middle Aged; Nicardipine; Nitrobenzenes; Piperazines | 1998 |
Inhibition by local anesthetics of Ca2+ channels in rat anterior pituitary cells.
Topics: Anesthetics, Local; Animals; Bupivacaine; Calcium Channel Blockers; Clone Cells; Dihydropyridines; Dose-Response Relationship, Drug; Lidocaine; Membrane Potentials; Nicardipine; Patch-Clamp Techniques; Pituitary Gland, Anterior; Rats | 1998 |
Requirement of expression of P-glycoprotein on human natural killer leukemia cells for cell-mediated cytotoxicity.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line; Cell Survival; Cytotoxicity, Immunologic; Dihydropyridines; Drug Resistance, Multiple; Humans; Killer Cells, Natural; Nicardipine; Oligonucleotides, Antisense; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrazoles; RNA, Messenger; Thymoma; Thymus Neoplasms; Transcription, Genetic; Tumor Cells, Cultured | 1998 |
Neuroprotective effects of a dihydropyridine derivative, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarbox ylic acid methyl 6-(5-phenyl-3-pyrazolyloxy)hexyl ester (CV-159), on rat ischemic brain injury.
Topics: Animals; Body Temperature; Brain Edema; Calcium Channel Blockers; Calcium-Calmodulin-Dependent Protein Kinases; Cell Death; Cerebral Infarction; Dihydropyridines; Hemodynamics; Hippocampus; Ischemic Attack, Transient; Male; Neurons; Neuroprotective Agents; Nicardipine; Nifedipine; Rats; Rats, Sprague-Dawley; Sulfonamides; Time Factors; Water | 1999 |
Effects of long-acting versus short-acting calcium channel blockers among older survivors of acute myocardial infarction.
Topics: Aged; Calcium Channel Blockers; Dihydropyridines; Diltiazem; Female; Humans; Male; Myocardial Infarction; Nicardipine; Nifedipine; Proportional Hazards Models; Retrospective Studies; Risk; Survival Analysis; Survivors; Verapamil | 1999 |
Effects of some 1,4-dihydropyridine Ca antagonists on the blast transformation of rat spleen lymphocytes.
Topics: Animals; Calcium Channel Blockers; Dihydropyridines; Lymphocyte Activation; Nicardipine; Nifedipine; Nimodipine; Rats; Spleen | 1999 |
Therapeutic effects of a calcium antagonist, lacidipine, on stroke-prone spontaneously hypertensive rats with cerebrovascular lesions.
Topics: Animals; Blood Pressure; Body Weight; Brain; Calcium Channel Blockers; Cerebellum; Cerebrovascular Disorders; Dihydropyridines; Hypertension; Kidney; Male; Nicardipine; Rats; Rats, Inbred SHR; Recurrence; Regional Blood Flow; Renal Artery; Systole | 1999 |
Resolution of newly synthesized racemic dihydropyridines with different chiral selectors by means of capillary electrophoresis.
Topics: Amlodipine; Calcium Channel Blockers; Cyclodextrins; Dihydropyridines; Electrophoresis, Capillary; Nicardipine; Stereoisomerism | 1999 |
Effect of benidipine on depolarizing stimulation-induced increase of intracellular calcium concentration in cultured mouse hippocampal neurons.
Topics: Animals; Calcium; Calcium Channel Blockers; Cells, Cultured; Dihydropyridines; Electric Stimulation; Hippocampus; Mice; Neurons; Nicardipine; Nifedipine | 1999 |
Effect of calcium antagonists on glomerular arterioles in spontaneously hypertensive rats.
Topics: Albuminuria; Animals; Arterioles; Calcium; Calcium Channel Blockers; Dihydropyridines; Hydralazine; Hypertension, Renal; Juxtaglomerular Apparatus; Male; Nicardipine; Nitrobenzenes; Piperazines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Renal Circulation; Vasodilator Agents | 2000 |
Possible requirement of phosphonate moiety for efonidipine effects on the sino-atrial node action potential.
Topics: Action Potentials; Animals; Calcium Channel Blockers; Dihydropyridines; Male; Nicardipine; Nitrophenols; Organophosphorus Compounds; Rabbits; Sinoatrial Node; Structure-Activity Relationship | 2000 |
Modulation of tumor necrosis factor-alpha production with anti-hypertensive drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Amlodipine; Animals; Antihypertensive Agents; Calcium Channel Blockers; Cells, Cultured; Dihydropyridines; Diuretics; Doxazosin; Humans; Hydrochlorothiazide; Interleukin-1; Interleukin-6; Lipopolysaccharides; Male; Metoprolol; Mice; Mice, Inbred BALB C; Monocytes; Nicardipine; Nitrobenzenes; Piperazines; Sodium Chloride Symporter Inhibitors; Tumor Necrosis Factor-alpha | 2000 |
Antinociceptive effect of cilnidipine, a novel N-type calcium channel antagonist.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, N-Type; Dihydropyridines; Dose-Response Relationship, Drug; Ganglia, Spinal; Gene Expression; In Situ Hybridization; Mice; Mice, Inbred C57BL; Nicardipine; Nociceptors; RNA, Messenger; Synaptic Transmission | 2000 |
Inhibitory effects of AE0047, a new dihydropyridine Ca(2+) channel blocker, on renal nerve stimulation-induced renal actions in anesthetized dogs.
Topics: Anesthesia; Animals; Calcium Channel Blockers; Dihydropyridines; Dogs; Electric Stimulation; Female; Infusions, Intra-Arterial; Kidney; Male; Nicardipine; Renal Circulation | 2000 |
In search of selective P2 receptor ligands: interaction of dihydropyridine derivatives at recombinant rat P2X(2) receptors.
Topics: Adenosine Triphosphate; Animals; Dihydropyridines; Ligands; Magnetic Resonance Spectroscopy; Nicardipine; Oocytes; Purinergic P2 Receptor Antagonists; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2X2; Recombinant Proteins; Xenopus | 2000 |
Overlapping selectivity of neurotoxin and dihydropyridine calcium channel blockers in cerebellar granule neurones.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Cells, Cultured; Cerebellum; Dihydropyridines; Dose-Response Relationship, Drug; Electric Stimulation; Membrane Potentials; Neurons; Neurotoxins; Nicardipine; omega-Agatoxin IVA; omega-Conotoxin GVIA; omega-Conotoxins; Rats; Rats, Sprague-Dawley | 2000 |
Nephroprotective effect of treatment with calcium channel blockers in spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Hydralazine; Kidney; Kidney Cortex; Kidney Glomerulus; Kidney Tubules; Male; Nicardipine; Nitrobenzenes; Piperazines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vasodilator Agents | 2000 |
Effects of long-term treatment with calcium antagonists on periarterial nerve function in the mesenteric artery of spontaneously hypertensive rats.
Topics: Amlodipine; Animals; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Drug Interactions; Hypertension; Male; Mesenteric Arteries; Nervous System; Nicardipine; Norepinephrine; Rats; Rats, Inbred SHR; Vasoconstrictor Agents; Vasodilator Agents | 2000 |
Modulation of glycine responses by dihydropyridines and verapamil in rat spinal neurons.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Cells, Cultured; Chloride Channels; Dihydropyridines; Drug Interactions; Glycine; Neural Inhibition; Neurons; Nicardipine; Nifedipine; Nitrendipine; Rats; Receptors, GABA-A; Receptors, Glycine; Spinal Cord; Synaptic Transmission; Verapamil | 2001 |
Searching for balanced hybrid NO-donor 1,4-dihydropyridines with basic properties.
Topics: Animals; Aorta, Thoracic; Calcium Channel Blockers; Dihydropyridines; Dose-Response Relationship, Drug; Nicardipine; Nitric Oxide; Nitric Oxide Donors; Rats; Vasodilation | 2001 |
Detailed characterization of cysteine-less P-glycoprotein reveals subtle pharmacological differences in function from wild-type protein.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Baculoviridae; Binding Sites; Cell Membrane; Cells, Cultured; Cross-Linking Reagents; Cysteine; Dihydropyridines; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Humans; Inhibitory Concentration 50; Kinetics; Mutagenesis; Nicardipine; Photoaffinity Labels; Serine; Spodoptera; Vinblastine | 2001 |
Effects of dihydropyridine-type Ca2+ antagonists on the renal arterial tree in spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Hydralazine; Kidney; Male; Nicardipine; Nitrobenzenes; Piperazines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Renal Artery; Tunica Media; Vasodilator Agents | 2002 |
Effects of 3-chloro-phenyl-1,4-dihydropyridine derivatives on Trypanosome cruzi epimastigotes.
Topics: Animals; Calcium Channel Blockers; Cell Movement; Dihydropyridines; Electrochemistry; Felodipine; Nicardipine; Oxidation-Reduction; Oxygen Consumption; Trypanocidal Agents; Trypanosoma cruzi | 2000 |
Role of dihydropyridine-sensitive calcium channels in the regulation of norepinephrine release in hypertension.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Dose-Response Relationship, Drug; Hypertension; Male; Mesenteric Arteries; Nicardipine; Norepinephrine; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 2001 |
Comparison of the direct negative dromotropic effect of a new calcium channel blocker, cilnidipine, with that of nicardipine.
Topics: Aged; Analysis of Variance; Animals; Atrial Fibrillation; Bradycardia; Calcium Channel Blockers; Dihydropyridines; Dogs; Electrocardiography; Female; Humans; Hypertension; Nicardipine | 2005 |
The calcium channel blockers, 1,4-dihydropyridines, are substrates of the multidrug resistance-linked ABC drug transporter, ABCG2.
Topics: Adenosine Triphosphate; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Azides; Calcium Channel Blockers; Cell Line; Chlorophyll; Dihydropyridines; Drug Interactions; Humans; Mitoxantrone; Neoplasm Proteins; Nicardipine; Nifedipine; Photoaffinity Labels; Prazosin | 2006 |
Azelnidipine attenuates cardiovascular and sympathetic responses to air-jet stress in genetically hypertensive rats.
Topics: Administration, Oral; Animals; Azetidinecarboxylic Acid; Blood Pressure; Calcium Channel Blockers; Cardiovascular System; Dihydropyridines; Dose-Response Relationship, Drug; Heart Rate; Homeostasis; Hypertension; Injections, Intravenous; Male; Nicardipine; Rats; Rats, Inbred SHR; Stress, Physiological; Sympathetic Nervous System; Time Factors | 2007 |
Assessment of the effects of L- and N-type Ca2+ channel blocking drugs using canine blood-perfused papillary muscle preparations.
Topics: Adrenergic alpha-Agonists; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, N-Type; Dihydropyridines; Dogs; Dose-Response Relationship, Drug; Microdialysis; Muscle Contraction; Myocardium; Nicardipine; Norepinephrine; omega-Conotoxin GVIA; Papillary Muscles | 2007 |
Effects of calcium channel blockers on hyaluronidase-induced capillary vascular permeability.
Topics: Amlodipine; Animals; Calcium Channel Blockers; Capillary Permeability; Carrageenan; Dihydropyridines; Hyaluronoglucosaminidase; Inflammation; Injections, Intravenous; Male; Nicardipine; Rats; Rats, Wistar | 2008 |
Oral administration of cilnidipine to patients with hypertensive intracerebral hemorrhage in the acute stage: significance and role of an N-type calcium channel blocker.
Topics: Acute Disease; Adult; Aged; Blood Pressure; Calcium Channel Blockers; Calcium Channels, N-Type; Dihydropyridines; Female; Hematoma; Humans; Intracranial Hemorrhage, Hypertensive; Male; Middle Aged; Nicardipine; Treatment Outcome | 2009 |
Differential sensitivities of CaV1.2 IIS5-S6 mutants to 1,4-dihydropyridine analogs.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Dihydropyridines; Dose-Response Relationship, Drug; Inhibitory Concentration 50; Mutant Proteins; Nicardipine; Point Mutation; Protein Structure, Tertiary; Pyridines; Rats; Substrate Specificity | 2009 |
Distinct properties of amlodipine and nicardipine block of the voltage-dependent Ca2+ channels Cav1.2 and Cav2.1 and the mutant channels Cav1.2/dihydropyridine insensitive and Cav2.1/dihydropyridine sensitive.
Topics: Amino Acid Sequence; Amlodipine; Binding Sites; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, N-Type; Dihydropyridines; HEK293 Cells; Humans; Molecular Sequence Data; Mutation; Nicardipine; Protein Conformation | 2011 |
Cisternal sustained release dihydropyridines for subarachnoid hemorrhage.
Topics: Animals; Delayed-Action Preparations; Dihydropyridines; Disease Models, Animal; Dogs; Female; Macaca fascicularis; Nicardipine; Nimodipine; Placebos; Subarachnoid Hemorrhage; Vasodilator Agents; Vasospasm, Intracranial | 2012 |
Detection of dihydropyridine- and voltage-sensitive intracellular Ca(2+) signals in normal human parathyroid cells.
Topics: Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Calcium Signaling; Dihydropyridines; Humans; Nicardipine; Parathyroid Glands | 2013 |
Pharmacokinetic drug-drug interaction of calcium channel blockers with cyclosporine in hematopoietic stem cell transplant children.
Topics: Adolescent; Amlodipine; Calcium Channel Blockers; Child; Child, Preschool; Cyclosporine; Dihydropyridines; Drug Interactions; Female; Hematopoietic Stem Cell Transplantation; Humans; Hypertension; Immunosuppressive Agents; Infant; Male; Nicardipine; Retrospective Studies | 2014 |
Comparison of anti-anginal effect of cilnidipine with those of nicardipine and nifedipine in the vasopressin-induced angina model of rats.
Topics: Angina Pectoris; Animals; Blood Pressure; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, N-Type; Coronary Vasospasm; Coronary Vessels; Dihydropyridines; Disease Models, Animal; Dose-Response Relationship, Drug; Electrocardiography; Heart Rate; Male; Nicardipine; Nifedipine; Rats; Time Factors; Vasoconstriction; Vasodilator Agents; Vasopressins | 2016 |
N- and L-type calcium channels blocker cilnidipine ameliorates neuropathic pain.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, N-Type; Conotoxins; Dihydropyridines; Evoked Potentials; Long-Term Potentiation; Male; Mice; Nerve Fibers, Unmyelinated; Neuralgia; Nicardipine; Rats; Spinal Cord Dorsal Horn | 2016 |
Repurposing the Dihydropyridine Calcium Channel Inhibitor Nicardipine as a Na
Topics: Animals; Behavior Control; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Disease Models, Animal; Drug Discovery; Drug Repositioning; Facies; Fear; Gene Expression Regulation; Humans; Hyperventilation; Intellectual Disability; Male; Mice; NAV1.8 Voltage-Gated Sodium Channel; Nicardipine; Phenotype; Social Skills; Transcription Factor 4 | 2020 |
Hypoxia Associated With Dihydropyridine Calcium Channel Inhibitors: A Pharmacovigilance Study in VigiBase.
Topics: Calcium Channels; Dihydropyridines; Humans; Hypoxia; Nicardipine; Pharmacovigilance; World Health Organization | 2023 |