nicaraven has been researched along with niacinamide in 38 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (10.53) | 18.7374 |
| 1990's | 15 (39.47) | 18.2507 |
| 2000's | 12 (31.58) | 29.6817 |
| 2010's | 3 (7.89) | 24.3611 |
| 2020's | 4 (10.53) | 2.80 |
| Authors | Studies |
|---|---|
| Asano, T; Koide, T; Matsushita, H; Takakura, K | 1 |
| Asano, T; Gotoh, O; Johshita, H; Koide, T; Shigeno, T; Takakura, K; Usui, M | 1 |
| Asano, T; Johshita, H; Koide, T; Takakura, K | 1 |
| Hata, S; Koide, T; Matsushita, H; Mizukami, M; Nakano, M; Neichi, T; Noda, Y; Yamazaki, T | 1 |
| Nohara, H; Okada, M; Ota, T; Yoshimura, N | 1 |
| Abe, H; Houkin, K; Iwasaki, Y; Kamada, K | 1 |
| Fujita, T; Hayakawa, T; Kumura, E; Maruno, M; Masana, Y; Yoshimine, T | 1 |
| Asano, T; Kikuchi, H; Nagai, H; Ochiai, C; Saito, I; Sano, K; Sasaki, T; Takakura, K; Tamura, A | 1 |
| Kamada, K | 1 |
| Alam, MS; Hashimoto, M; Iwasaki, S; Kin, S; Ku, K; Nakayama, K; Nosaka, S; Saitoh, Y | 1 |
| Kassell, NF; Lee, KS; Toyoda, T | 1 |
| Alam, MS; Hashimoto, M; Ku, K; Masumura, S; Nakayama, K; Nosaka, S; Saitoh, Y; Tamura, K; Yamauchi, M | 1 |
| Alam, MS; Hashimoto, M; Hossain, MS; Ku, K; Masumura, S; Nakayama, K; Nosaka, S; Tamura, K; Yamauchi, M | 1 |
| Costa, G; d'Avella, D; Germanò, A; Imperatore, C; Tomasello, F | 2 |
| Ishikawa, T; Kawai, S; Marsala, M; Sakabe, T; Taguchi, T; Yamamoto, K | 1 |
| Ishigai, M; Ishitani, Y; Kamiyama, H; Kumaki, K; Orikasa, Y | 1 |
| Hayakawa, T; Kosaka, H; Kumura, E; Maruno, M; Taniguchi, M; Yamanaka, K; Yoshimine, T | 1 |
| Endo, T; Iwamura, M; Koshiba, K; Kumano, K; Masaki, Y; Okubo, M; Yokota, K | 1 |
| Hashimoto, H; Kumon, Y; Matsuda, S; Ohta, S; Sakaki, S; Sakanaka, M; Utsunomiya, H | 1 |
| Hake, P; Salzman, AL; Scott, GS; Szabo, C; Zingarelli, B | 1 |
| Akimoto, T | 1 |
| Kakiuchi, T; Nishizawa, S; Teng, W; Tsukada, H; Yamamoto, S | 1 |
| Fukai, M; Furukawa, H; Hayashi, T; Kishida, A; Nagashima, K; Shimamura, T; Suzuki, T; Todo, S; Watanabe, Y; Yokota, R | 1 |
| Jain, KK | 1 |
| Ascenti, G; Blandino, A; Granata, F; Longo, M; Ricciardi, GK; Vinci, S | 1 |
| Naritomi, H | 1 |
| Leker, RR | 1 |
| Manome, Y; Watanabe, M; Yoshinaga, H | 1 |
| Igarashi, H; Katayama, Y | 1 |
| Hirano, M; Oka, T; Shimada, Y; Tanaka, T; Tsunoda, H; Zang, L | 1 |
| Goto, S; Imai, R; Kawakatsu, M; Li, TS; Nishida, N; Ono, Y; Urata, Y | 1 |
| Abdelrahim, E; Ali, H; Galal, O; Goto, S; Guo, CY; Li, TS; Luo, L; Mostafa, E; Ono, Y; Urata, Y | 1 |
| Goto, S; Li, TS; Luo, L; Urata, Y; Yan, C | 1 |
| Goto, S; Guo, CY; Kawabata, T; Li, TS; Liu, KX; Moriwaki, T; Zhang, X | 1 |
| Abdelghany, L; El-Mahdy, N; Goto, S; Jingu, K; Kawabata, T; Li, TS; Zhang, X | 1 |
| Goto, S; Jingu, K; Li, TS; Xu, Y; Zhai, D; Zhang, X | 1 |
| Abdelghany, L; Jingu, K; Li, TS; Sekiya, R; Xu, Y; Yan, C | 1 |
4 review(s) available for nicaraven and niacinamide
| Article | Year |
|---|---|
Nicaraven for the treatment of cerebral vasospasm in subarachnoid haemorrhage.
Topics: Animals; Antioxidants; Clinical Trials as Topic; Humans; Niacinamide; Subarachnoid Hemorrhage; Vasospasm, Intracranial | 2000 |
[Neuroprotective therapy for the treatment of acute ischemic stroke].
Topics: Animals; Antioxidants; Antipyrine; Clinical Trials as Topic; Edaravone; Free Radical Scavengers; Humans; Hypothermia, Induced; Neuroprotective Agents; Niacinamide; Stroke; Time Factors | 2001 |
Nicaraven Chugai.
Topics: Animals; Antioxidants; Brain Edema; Brain Ischemia; Cerebral Hemorrhage; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Humans; Neuroprotective Agents; Niacinamide; Stroke; Structure-Activity Relationship | 2003 |
[Advances in the diagnosis and treatment of cerebral ischemia during the acute phase].
Topics: Acute-Phase Reaction; Antipyrine; Brain Ischemia; Cerebrovascular Circulation; Drug Design; Drug Therapy, Combination; Edaravone; Humans; Immunosuppressive Agents; Magnetic Resonance Imaging; Nerve Growth Factors; Neuroprotective Agents; Niacinamide; Recombinant Proteins; Tacrolimus; Time Factors; Tissue Plasminogen Activator | 2003 |
1 trial(s) available for nicaraven and niacinamide
| Article | Year |
|---|---|
Effects of a hydroxyl radical scavenger on delayed ischemic neurological deficits following aneurysmal subarachnoid hemorrhage: results of a multicenter, placebo-controlled double-blind trial.
Topics: Adult; Aged; Double-Blind Method; Female; Free Radical Scavengers; Humans; Hydroxyl Radical; Intracranial Aneurysm; Male; Middle Aged; Niacinamide; Subarachnoid Hemorrhage; Time Factors; Treatment Outcome | 1996 |
33 other study(ies) available for nicaraven and niacinamide
| Article | Year |
|---|---|
Enhancement of ATPase activity by a lipid peroxide of arachidonic acid in rat brain microvessels.
Topics: Adenosine Triphosphatases; Animals; Arachidonic Acids; Brain; Brain Edema; Ca(2+) Mg(2+)-ATPase; Dose-Response Relationship, Drug; Fatty Acids; Free Radicals; Hydroquinones; Leukotrienes; Lipid Peroxides; Lipoxygenase; Niacinamide; Phospholipases A; Phospholipases A2; Quinacrine; Rats; Sodium-Potassium-Exchanging ATPase; Synaptosomes; Vitamin E | 1986 |
[The pathomechanism underlying ischemic brain edema: the role of Na+, K+-ATPase of the brain microvessels].
Topics: Animals; Brain Chemistry; Brain Edema; Brain Ischemia; Cats; Cerebrovascular Circulation; Disease Models, Animal; Eicosanoic Acids; Fatty Acids, Nonesterified; Free Radicals; Microcirculation; Niacinamide; Potassium; Sodium; Sodium-Potassium-Exchanging ATPase | 1985 |
Amelioration of ischaemic cerebral oedema by a free radical scavenger, AVS: 1,2-bis(nicotinamido)-propane. An experimental study using a regional ischaemia model in cats.
Topics: Animals; Brain Edema; Brain Ischemia; Cats; Cerebral Cortex; Disease Models, Animal; Energy Metabolism; Female; Free Radicals; Male; Niacinamide; Oxygen; Regional Blood Flow; Water-Electrolyte Balance | 1984 |
Effects of AVS (1,2-bis(nicotinamido)propane) on platelet function and vascular endothelium.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Blood Vessels; Cerebrovascular Disorders; Collagen; Dinoprostone; Endothelium; In Vitro Techniques; Mice; Microscopy, Electron, Scanning; Niacinamide; Platelet Aggregation; Prostaglandins E; Rabbits; Rats; Rats, Inbred Strains; Thromboembolism; Thrombosis; Thromboxane A2 | 1984 |
Pharmacologic intervention for ischemic brain edema after retrograde cerebral perfusion.
Topics: Animals; Aorta, Thoracic; Aortic Aneurysm, Thoracic; Brain; Brain Edema; Brain Ischemia; Cardiopulmonary Bypass; Cerebrovascular Circulation; Dogs; Free Radical Scavengers; Mannitol; Niacinamide; Perfusion; Time Factors | 1995 |
A high-field magnetic resonance imaging study of experimental vasogenic brain edema and its response to AVS: 1,2-bis (nicotinamido)-propane.
Topics: Animals; Antioxidants; Blood-Brain Barrier; Brain Edema; Brain Injuries; Cerebral Cortex; Corpus Callosum; Female; Freezing; Niacinamide; Rats; Rats, Wistar | 1994 |
Reaction of microglial cells and macrophages after cortical incision in rats: effect of a synthesized free radical scavenger, (+/-)-N,N'-propylenedinicotinamide (AVS)
Topics: Animals; Cell Count; Free Radical Scavengers; Immunohistochemistry; Macrophages; Male; Microglia; Niacinamide; Rats; Rats, Wistar; Time Factors | 1995 |
[Sequential observations of brain edema with proton magnetic resonance imaging and spectroscopy].
Topics: Aged; Animals; Brain Edema; Female; Free Radical Scavengers; Glutamine; Humans; Lactates; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Middle Aged; Monitoring, Physiologic; Niacinamide; Protons; Rats; Rats, Wistar | 1996 |
The role of a hydroxyl radical scavenger (nicaraven) in recovery of cardiac function following preservation and reperfusion.
Topics: Animals; Biomarkers; Body Water; Catalase; Creatine Kinase; Free Radical Scavengers; Heart; Hydroxyl Radical; Lactates; Male; Myocardial Reperfusion Injury; Niacinamide; Organ Preservation; Rats; Rats, Wistar; Superoxide Dismutase; Troponin; Troponin T | 1996 |
Attenuation of ischemia-reperfusion injury in the rat neocortex by the hydroxyl radical scavenger nicaraven.
Topics: Animals; Brain Ischemia; Cerebral Cortex; Cerebral Infarction; Free Radical Scavengers; Hydroxyl Radical; Male; Niacinamide; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 1997 |
Hydroxyl radical scavenging effect of nicaraven in myocardial and coronary endothelial preservation and reperfusion injury.
Topics: Animals; Coronary Circulation; Coronary Vessels; Endothelium, Vascular; Ferrous Compounds; Free Radical Scavengers; Hydrogen Peroxide; Hydroxyl Radical; In Vitro Techniques; Male; Models, Biological; Myocardial Reperfusion Injury; Niacinamide; Rats; Rats, Wistar; Swine | 1997 |
Protective effects of nicaraven, a new hydroxyl radical scavenger, on the endothelial dysfunction after exposure of pig coronary artery to hydroxyl radicals.
Topics: Animals; Bradykinin; Coronary Vessels; Dimethyl Sulfoxide; Dinoprost; Endothelium, Vascular; Ferrous Compounds; Free Radical Scavengers; Hydrogen Peroxide; Hydroxyl Radical; In Vitro Techniques; Myocardial Reperfusion Injury; Niacinamide; Nitric Oxide; Rats; Regional Blood Flow; Swine; Vasoconstrictor Agents; Vasodilator Agents | 1998 |
Antivasospastic and brain-protective effects of a hydroxyl radical scavenger (AVS) after experimental subarachnoid hemorrhage.
Topics: Animals; Antioxidants; Basilar Artery; Behavior, Animal; Blood-Brain Barrier; Body Weight; Brain; Brain Ischemia; Brain Stem; Cerebellum; Cerebral Cortex; Coloring Agents; Evans Blue; Extravasation of Diagnostic and Therapeutic Materials; Free Radical Scavengers; Hydroxyl Radical; Ischemic Attack, Transient; Male; Neuroprotective Agents; Niacinamide; Permeability; Postural Balance; Radiography; Rats; Rats, Sprague-Dawley; Subarachnoid Hemorrhage; Walking | 1998 |
The hydroxyl radical scavenger Nicaraven inhibits glutamate release after spinal injury in rats.
Topics: Animals; Free Radical Scavengers; Glutamic Acid; Hydroxyl Radical; Hypothermia, Induced; Male; Niacinamide; Rats; Rats, Sprague-Dawley; Reference Values; Spinal Cord; Spinal Cord Injuries; Time Factors | 1998 |
Metabolism of 2(R,S)-1,2-bis(nicotinamido)propane, a new agent with anti-vasospasm activity, in rats and rabbits.
Topics: Aldehyde Oxidoreductases; Animals; Antioxidants; Bile; Biotransformation; Cytosol; Feces; In Vitro Techniques; Liver; Male; Mass Spectrometry; Niacinamide; Rabbits; Rats; Rats, Sprague-Dawley | 1998 |
Cellular expression of inducible nitric oxide synthase following rat cortical incision and its suppression by hydroxyl radical scavenger, 1,2-bis(nicotinamido)propane.
Topics: Animals; Antibodies; Brain Injuries; Cerebral Cortex; Free Radical Scavengers; Hydroxyl Radical; Macrophages; Male; Niacinamide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley | 1998 |
Protective effect of nicaraven against prolonged cold kidney preservation and reperfusion injury.
Topics: Adenosine; Allopurinol; Animals; Antioxidants; Cold Temperature; Creatinine; Diuresis; Dogs; Glutathione; Hypertonic Solutions; In Vitro Techniques; Insulin; Kidney; Kidney Transplantation; Male; Niacinamide; Organ Preservation; Organ Preservation Solutions; Raffinose; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Transplantation, Autologous | 1998 |
Changes in guanylate cyclase activity in arteriolar smooth muscle cells and hemodynamics after ischemia-reperfusion in rats.
Topics: Animals; Cerebrovascular Circulation; Enzyme Inhibitors; Free Radical Scavengers; Free Radicals; Guanylate Cyclase; Hemodynamics; Male; Muscle, Smooth, Vascular; Niacinamide; Nitric Oxide; Nitroarginine; Nitroprusside; Rats; Rats, Wistar; Reperfusion Injury; Signal Transduction; Sodium Chloride; Time Factors; Vasodilator Agents | 1999 |
Effects of nicaraven on nitric oxide-related pathways and in shock and inflammation.
Topics: Animals; Antioxidants; Arthritis, Experimental; Carrageenan; Dose-Response Relationship, Drug; Edema; Enzyme Activation; Free Radical Scavengers; Inflammation; Interferon-gamma; Lipopolysaccharides; Macrophage Activation; Male; Mice; Mice, Inbred DBA; Niacinamide; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidation-Reduction; Poly(ADP-ribose) Polymerases; Rats; Rats, Wistar; Reperfusion Injury; Shock, Hemorrhagic; Shock, Septic; Splanchnic Circulation | 2000 |
Effects of the radical scavenger AVS on behavioral and BBB changes after experimental subarachnoid hemorrhage.
Topics: Animals; Behavior, Animal; Blood-Brain Barrier; Dose-Response Relationship, Drug; Free Radical Scavengers; Hemodynamics; Male; Niacinamide; Postural Balance; Rats; Rats, Sprague-Dawley; Subarachnoid Hemorrhage; Time Factors; Walking | 2000 |
Quantitative analysis of the kinetic constant of the reaction of N,N'-propylenedinicotinamide with the hydroxyl radical using dimethyl sulfoxide and deduction of its structure in chloroform.
Topics: Antioxidants; Chloroform; Dimethyl Sulfoxide; Free Radical Scavengers; Hydrocarbons; Hydroxyl Radical; Kinetics; Methane; Models, Chemical; Models, Molecular; Niacinamide | 2000 |
Improvement in cerebral blood flow and metabolism following subarachnoid hemorrhage in response to prophylactic administration of the hydroxyl radical scavenger, AVS, (+/-)-N,N'-propylenedinicotinamide: a positron emission tomography study in rats.
Topics: Animals; Brain; Cerebrovascular Circulation; Free Radical Scavengers; Glucose; Male; Niacinamide; Postoperative Period; Rats; Rats, Sprague-Dawley; Subarachnoid Hemorrhage; Tomography, Emission-Computed; Vasospasm, Intracranial | 2000 |
A novel hydroxyl radical scavenger, nicaraven, protects the liver from warm ischemia and reperfusion injury.
Topics: Adenine Nucleotides; Animals; Dogs; Endothelin-1; Female; Free Radical Scavengers; Hemodynamics; Humans; Hydroxyl Radical; Indocyanine Green; Lipid Peroxidation; Liver; Liver Circulation; Liver Transplantation; Niacinamide; Organ Preservation; Reperfusion Injury; Temperature | 2000 |
Cerebral angiography in the rat with mammographic equipment: a simple, cost-effective method for assessing vasospasm in experimental subarachnoid haemorrhage.
Topics: Animals; Cerebral Angiography; Cost-Benefit Analysis; Free Radical Scavengers; Male; Mammography; Niacinamide; Rats; Rats, Sprague-Dawley; Subarachnoid Hemorrhage; Vasospasm, Intracranial | 2002 |
Possible role of nicaraven in neuroprotective effect on hippocampal slice culture.
Topics: Animals; Cell Death; Dose-Response Relationship, Drug; Hippocampus; Mice; Mice, Inbred ICR; Neuroprotective Agents; Niacinamide; Organ Culture Techniques | 2003 |
Synergistic induction of heme oxygenase-1 by nicaraven after subarachnoid hemorrhage to prevent delayed cerebral vasospasm.
Topics: Animals; Basilar Artery; Cerebral Angiography; Cyclic GMP; Enzyme Induction; Gene Expression Regulation, Enzymologic; Heme Oxygenase-1; Humans; Male; Niacinamide; Oligodeoxyribonucleotides, Antisense; Oxyhemoglobins; Promoter Regions, Genetic; Rats; Rats, Sprague-Dawley; Subarachnoid Hemorrhage; Time Factors; Vasospasm, Intracranial | 2009 |
Nicaraven attenuates radiation-induced injury in hematopoietic stem/progenitor cells in mice.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Deoxyguanosine; Gamma Rays; Hematopoietic Stem Cells; Interleukin-6; Male; Mice; Mice, Inbred C57BL; Niacinamide; Radiation Injuries; Tumor Necrosis Factor-alpha | 2013 |
The potential benefits of nicaraven to protect against radiation-induced injury in hematopoietic stem/progenitor cells with relative low dose exposures.
Topics: Animals; Antioxidants; Biomarkers; Gamma Rays; Gene Expression Profiling; Gene Expression Regulation; Hematopoietic Stem Cells; Male; Mice; Mice, Inbred C57BL; Niacinamide; Proto-Oncogene Proteins c-kit; Radiation Injuries; Radiation-Protective Agents; Reactive Oxygen Species | 2014 |
Nicaraven reduces cancer metastasis to irradiated lungs by decreasing CCL8 and macrophage recruitment.
Topics: Amifostine; Animals; Antioxidants; Cell Line, Tumor; Chemokine CCL8; Gamma Rays; Humans; Lung; Lung Neoplasms; Macrophages; Mice, Inbred C57BL; Niacinamide; Radiation Tolerance; Radiation-Protective Agents | 2018 |
Nicaraven Attenuates Postoperative Systemic Inflammatory Responses-Induced Tumor Metastasis.
Topics: Animals; Cytokines; Inflammation; Lung; Lung Neoplasms; Male; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; Niacinamide; Reperfusion Injury; Surgical Procedures, Operative; Systemic Inflammatory Response Syndrome | 2020 |
Nicaraven prevents the fast growth of inflamed tumors by an anti-inflammatory mechanism.
Topics: Animals; Anti-Inflammatory Agents; Biomarkers, Tumor; Cytokines; Humans; Inflammation; Macrophages; Male; Mice; Mice, Inbred C57BL; Neoplasms; Niacinamide; Tumor Microenvironment | 2021 |
Nicaraven mitigates radiation-induced lung injury by downregulating the NF-κB and TGF-β/Smad pathways to suppress the inflammatory response.
Topics: Animals; Humans; Lung; Lung Injury; Mice; Mice, Inbred C57BL; NF-kappa B; Niacinamide; Transforming Growth Factor beta | 2022 |
Nicaraven Exerts a Limited Effect on Radiation-Induced Inhibition of Tumor Growth in a Subcutaneous Murine Tumor Model.
Topics: Animals; Antioxidants; Mice; Neoplasms; Niacinamide; Radiation Injuries | 2023 |