niacinamide and s-adenosylmethionine

niacinamide has been researched along with s-adenosylmethionine in 36 studies

Research

Studies (36)

TimeframeStudies, this research(%)All Research%
pre-199012 (33.33)18.7374
1990's5 (13.89)18.2507
2000's1 (2.78)29.6817
2010's10 (27.78)24.3611
2020's8 (22.22)2.80

Authors

AuthorsStudies
Elmsjö, A; Green, H; Kugelberg, FC; Söderberg, C; Vikingsson, S1
Kim, YA; Kwon, SH; Lee, Y; Park, UC; Seo, JH; Yoo, HJ; Yoon, CK; Yu, HG1
Friedman, J; Goren, D; Razin, A1
Matthysse, S1
Henning, SM; McKee, RW; Swendseid, ME1
Black, MJ; Brandt, RB1
Halpern, RM; Jenkinson, P; Murai, JT; Smith, RA1
Buch, L; Halpern, RM; Simon, LN; Smith, RA; Stout, MG; Streeter, D1
Gross, HJ; Wildenauer, D1
Endo, H; Kuchino, Y1
Kuchino, Y1
Chao, KL; Simon, LN; Swiatek, KR1
Chou, L; Johnson, TC; Mathews, RA1
Chiang, PK; Johnson, GS1
Endo, N; Sano, A; Takitani, S1
Jenden, DJ; Vargas, HM1
Orgacka, H; Scheller, T; Szumlanski, CL; Weinshilboum, RM1
Gaby, AR1
McCarty, MF; Russell, AL1
Ramsden, DB; Williams, AC1
Calvisi, DF; Embade, N; Esteller, M; Fernández-Ramos, D; Frades, I; Fraga, MF; Julve, J; Lu, SC; Luka, Z; Martínez-Chantar, ML; Martínez-López, N; Mato, JM; Rodríguez, J; Rodríguez-Millán, E; Torres, L; Varela-Rey, M; Wagner, C; Woodhoo, A1
Emanuelli, M; Peng, Y; Pozzi, V; Sartini, D; Wilk, D; Yee, VC1
Du, H; Li, H; Lin, A; Peng, C; Qiu, W; Seewoo, V; Shen, B; Wang, J; Yang, W1
Alhonen, L; Asara, JM; Banks, AS; Bhanot, S; Cen, Y; Gong, F; Kahn, BB; Kong, D; Kraus, D; Monia, BP; Peroni, OD; Pirinen, E; Puigserver, P; Pulinilkunnil, TC; Rodgers, JT; Sauve, AA; Wang, YC; Yang, Q; Zhang, L1
Hsiao, HH; Liu, TP; Lo, HL; Wei, LS; Yang, PM1
Battle, SL; Bielas, JH; Blau, CA; Detraux, D; Devi, A; Ericson, NG; Ferreccio, A; Fiehn, O; Fischer, KA; Gu, H; Hawkins, RD; Hesson, J; Hockenbery, D; Margaretha, L; Margineantu, D; Margolin, AA; Mathieu, J; Moon, RT; Raftery, D; Robitaille, AM; Ruohola-Baker, H; Showalter, M; Sperber, H; Valensisi, C; Wang, Y; Ware, CB; Xu, Z1
Anand, NN; Birudukota, S; Burri, RR; Dhakshinamoorthy, S; Gosu, R; Hallur, MS; Juluri, S; Kandan, S; Kannt, A; Kristam, R; Langer, T; Parveen, R; Rajagopal, S; Rudolph, C; Ruf, S; Schreuder, H; Shaik, S; Swaminathan, S; Thakur, MK1
Loring, HS; Thompson, PR1
Albrecht, LV; Bui, MH; De Robertis, EM1
Andrade, J; Blaženović, I; Chang, JW; Chryplewicz, A; Coscia, F; Curtis, M; Eckert, MA; Fiehn, O; Hernandez, KM; Lastra, RR; Lengyel, E; Li, G; Mann, M; McGregor, SM; Moellering, RE; Nahotko, DA; Pan, S; Perets, R; Tienda, SM; Yamada, SD1
Darenskaya, MA; Grebenkina, LA; Kolesnikov, SI; Kolesnikova, LI; Okhremchuk, LV; Seminskii, IZ1
Goto, H; Hidoh, Y; Ishii, Y; Nishimura, Y; Sato, M; Takeuchi, K; Yokouchi, C1
Fernández, AF; Fraga, MF; Roberti, A1
Gao, Y; Martin, NI; van Haren, MJ1
Dymkowska, D; Mateuszuk, Ł; Stępińska, O; Zabłocki, K1
Antonova, EA; Belikova, TN; Kovalenko, AL; Morozov, VG; Popova, VB; Rafalskiy, VV; Stel'makh, VV; Uspenskiy, YP1

Reviews

5 review(s) available for niacinamide and s-adenosylmethionine

ArticleYear
[tRNA methylases].
    Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 1972, Volume: 17, Issue:4

    Topics: Animals; Base Sequence; Enzyme Activation; Escherichia coli; Methyltransferases; Niacinamide; Polysaccharides; Rats; Ribonucleases; RNA Nucleotidyltransferases; RNA, Transfer; S-Adenosylmethionine; Species Specificity; Yeasts

1972
Natural treatments for osteoarthritis.
    Alternative medicine review : a journal of clinical therapeutic, 1999, Volume: 4, Issue:5

    Topics: Boron; Chondroitin Sulfates; Glucosamine; Humans; Manganese; Niacinamide; Osteoarthritis; Phytotherapy; S-Adenosylmethionine; Vitamins

1999
Autotoxicity, methylation and a road to the prevention of Parkinson's disease.
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2005, Volume: 12, Issue:1

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Dopamine Agents; Humans; Methylation; Niacinamide; Parkinson Disease; Parkinson Disease, Secondary; Risk Factors; S-Adenosylmethionine

2005
Nicotinamide N-methyltransferase: At the crossroads between cellular metabolism and epigenetic regulation.
    Molecular metabolism, 2021, Volume: 45

    Topics: Adipose Tissue; Animals; Epigenesis, Genetic; Humans; Insulin Resistance; Liver; NAD; Neoplasms; Niacinamide; Nicotinamide N-Methyltransferase; Obesity; S-Adenosylmethionine

2021
Nicotinamide N-methyl transferase (NNMT): An emerging therapeutic target.
    Drug discovery today, 2021, Volume: 26, Issue:11

    Topics: Enzyme Inhibitors; Humans; Metabolic Diseases; Neoplasms; Neurodegenerative Diseases; Niacinamide; Nicotinamide N-Methyltransferase; S-Adenosylmethionine

2021

Trials

1 trial(s) available for niacinamide and s-adenosylmethionine

ArticleYear
[The results of phase III multicenter open randomized controlled study REM-Chol-III-16 in patients with intrahepatic cholestasis syndrome caused by chronic diffuse liver diseases].
    Terapevticheskii arkhiv, 2021, Dec-15, Volume: 93, Issue:12

    Topics: Alkaline Phosphatase; Bilirubin; Cholestasis, Intrahepatic; gamma-Glutamyltransferase; Humans; Inosine; Meglumine; Methionine; Niacinamide; S-Adenosylmethionine; Succinic Acid; Transaminases

2021

Other Studies

30 other study(ies) available for niacinamide and s-adenosylmethionine

ArticleYear
Post-Mortem Metabolomics: A Novel Approach in Clinical Biomarker Discovery and a Potential Tool in Death Investigations.
    Chemical research in toxicology, 2021, 06-21, Volume: 34, Issue:6

    Topics: Amino Acids; Biomarkers; Carnitine; Chromatography, High Pressure Liquid; Discriminant Analysis; Humans; Lipids; Metabolomics; Niacinamide; Nucleotides; Principal Component Analysis; Steroids

2021
Vitreous Fatty Amides and Acyl Carnitines Are Altered in Intermediate Age-Related Macular Degeneration.
    Investigative ophthalmology & visual science, 2023, 03-01, Volume: 64, Issue:3

    Topics: Amides; Carnitine; Humans; Macular Degeneration; Niacinamide; Succinates; Vitreous Body

2023
Studies on the biological role of DNA methylation: inhibition of methylation and maturation of the bacteriophage phichi174 by nicotinamide.
    Nucleic acids research, 1975, Volume: 2, Issue:10

    Topics: Coliphages; DNA (Cytosine-5-)-Methyltransferases; Kinetics; Methyltransferases; Niacinamide; S-Adenosylmethionine; Species Specificity

1975
On lowering S-adenosylmethionine.
    Monographien aus dem Gesamtgebiete der Psychiatrie, 1978, Volume: 18

    Topics: Animals; Levodopa; Liver; Methylation; Methyltransferases; Niacinamide; Norepinephrine; Rats; S-Adenosylmethionine

1978
Hepatic content of S-adenosylmethionine, S-adenosylhomocysteine and glutathione in rats receiving treatments modulating methyl donor availability.
    The Journal of nutrition, 1989, Volume: 119, Issue:10

    Topics: Animals; Biomarkers; Choline Deficiency; Cysteine; Diet; Fatty Liver; Folic Acid Deficiency; Glutathione; Homocysteine; Lipids; Liver; Male; Methionine; Methylation; Niacinamide; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine

1989
Nicotinic acid or N-methyl nicotinamide prolongs elevated brain dopa and dopamine in L-dopa treatment.
    Biochemical medicine and metabolic biology, 1986, Volume: 36, Issue:2

    Topics: Animals; Benserazide; Brain Chemistry; Dihydroxyphenylalanine; Dopamine; Levodopa; Liver; Male; Niacinamide; Nicotinic Acids; Rats; Rats, Inbred Strains; S-Adenosylmethionine

1986
The inhibition of tRNA methylase activity by nicotinamide and a non-dialyzable inhibitor.
    Biochemical and biophysical research communications, 1972, Jan-31, Volume: 46, Issue:2

    Topics: Ammonium Sulfate; Animals; Carbon Isotopes; Carcinosarcoma; Chemical Precipitation; Chromatography, Gel; Drug Synergism; Liver; Methyltransferases; Niacinamide; Rats; RNA, Transfer; S-Adenosylmethionine

1972
Inhibition of transfer ribonucleic acid methylase activity from several human tumors by nicotinamide and nicotinamide analogs.
    Biochemistry, 1972, Feb-01, Volume: 11, Issue:3

    Topics: Adenocarcinoma; Aldehydes; Amines; Animals; Carbon Isotopes; Carcinoma; Carcinoma 256, Walker; Cell Line; Colon; Colonic Neoplasms; Dysgerminoma; Humans; Kidney; Kidney Neoplasms; Kinetics; Liver; Male; Methyltransferases; Mouth Neoplasms; Niacinamide; Pyridines; Rats; RNA, Transfer; S-Adenosylmethionine; Testicular Neoplasms; Testis

1972
Enzymatic methylations. II. In vitro inhibition of tRNA and protein methylation by nicotinamide and isonicotinic acid hydrazide: activation of a s-adenosylmethionine-splitting enzyme in rat liver.
    Biochemical and biophysical research communications, 1972, Jul-11, Volume: 48, Issue:1

    Topics: Animals; Carbon Isotopes; Chromatography; Chromatography, Thin Layer; Enzyme Activation; Hydroxyapatites; Isoniazid; Liver; Methyltransferases; Niacinamide; Proteins; Rats; RNA, Transfer; S-Adenosylmethionine

1972
Nicotinamide and its methyltransferase as apparent inhibitors of tRNA methylase.
    Journal of biochemistry, 1972, Volume: 71, Issue:4

    Topics: Ammonium Sulfate; Animals; Calcium Phosphates; Chemical Precipitation; Chromatography; Escherichia coli; Female; Hydrogen-Ion Concentration; Kinetics; Liver; Methyltransferases; Niacinamide; Rats; RNA, Transfer; S-Adenosylmethionine; Spectrum Analysis

1972
Nicotinamide methyltransferase and S-adenosylmethionine: 5'-methylthioadenosine hydrolase. Control of transfer ribonucleic acid methylation.
    Biochemistry, 1973, Nov-06, Volume: 12, Issue:23

    Topics: Animals; Carbon Radioisotopes; Carcinoma; Cell Line; Chromatography, Gel; Chromatography, Thin Layer; Humans; Isoniazid; Isonicotinic Acids; Kinetics; Liver; Methyltransferases; Mouth Neoplasms; Niacinamide; Rats; S-Adenosylmethionine; Swine; Transferases; tRNA Methyltransferases

1973
tRNA methyltransferase activity in neonatal and mature mammalian neural tissue.
    Journal of neurochemistry, 1974, Volume: 23, Issue:3

    Topics: Aging; Animals; Animals, Newborn; Brain; Carbon Radioisotopes; Centrifugation, Density Gradient; Cytosol; Drug Stability; Escherichia coli; Hydrogen-Ion Concentration; Kinetics; Mice; Niacinamide; RNA, Bacterial; RNA, Transfer; S-Adenosylmethionine; Subcellular Fractions; Temperature; Time Factors; tRNA Methyltransferases; Ultracentrifugation

1974
1-methylnicotinamide and NAD metabolism in normal and transformed normal rat kidney cells.
    Archives of biochemistry and biophysics, 1981, Volume: 210, Issue:1

    Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Kidney; NAD; Niacinamide; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine; Tubercidin

1981
Fluorometric assay of rat brain N-methyltransferase with 4-methylnicotinamide.
    Biological & pharmaceutical bulletin, 1993, Volume: 16, Issue:3

    Topics: Aging; Animals; Brain; Chromatography, High Pressure Liquid; Enzyme Stability; Female; Kinetics; Male; Methyltransferases; Niacinamide; Rats; Rats, Sprague-Dawley; S-Adenosylmethionine; Spectrometry, Fluorescence

1993
Elevation of cerebrospinal fluid choline levels by nicotinamide involves the enzymatic formation of N1-methylnicotinamide in brain tissue.
    Life sciences, 1996, Volume: 58, Issue:22

    Topics: Acetylcholine; Animals; Brain; Choline; Chromatography, High Pressure Liquid; Male; Niacinamide; Rats; Rats, Sprague-Dawley; S-Adenosylmethionine; Spectrophotometry, Ultraviolet; Tritium

1996
Mouse liver nicotinamide N-methyltransferase pharmacogenetics: biochemical properties and variation in activity among inbred strains.
    Pharmacogenetics, 1996, Volume: 6, Issue:1

    Topics: Amodiaquine; Animals; Calcium; Chromatography, Ion Exchange; Enzyme Stability; Female; Humans; Hydrogen-Ion Concentration; Kinetics; Liver; Magnesium; Male; Methyltransferases; Mice; Mice, Inbred Strains; Niacinamide; Nicotinamide N-Methyltransferase; S-Adenosylhomocysteine; S-Adenosylmethionine; Sex Characteristics; Time Factors

1996
Niacinamide therapy for osteoarthritis--does it inhibit nitric oxide synthase induction by interleukin 1 in chondrocytes?
    Medical hypotheses, 1999, Volume: 53, Issue:4

    Topics: Antioxidants; Cartilage, Articular; Enzyme Inhibitors; Fish Oils; Glucosamine; Humans; Hyaluronic Acid; Interleukin-1; Niacinamide; Nitric Oxide Synthase; Osteoarthritis; S-Adenosylmethionine; Signal Transduction

1999
Fatty liver and fibrosis in glycine N-methyltransferase knockout mice is prevented by nicotinamide.
    Hepatology (Baltimore, Md.), 2010, Volume: 52, Issue:1

    Topics: Animals; Fatty Liver; Gene Deletion; Gene Expression; Glycine N-Methyltransferase; Liver Cirrhosis; Mice; Mice, Knockout; Niacinamide; S-Adenosylmethionine

2010
Structural basis of substrate recognition in human nicotinamide N-methyltransferase.
    Biochemistry, 2011, Sep-13, Volume: 50, Issue:36

    Topics: Binding Sites; Humans; Kinetics; Models, Molecular; Molecular Dynamics Simulation; Niacinamide; Nicotinamide N-Methyltransferase; Protein Conformation; S-Adenosylmethionine; Structure-Activity Relationship

2011
The different induction mechanisms of growth arrest DNA damage inducible gene 45 β in human hepatoma cell lines.
    Chemotherapy, 2012, Volume: 58, Issue:2

    Topics: Antigens, Differentiation; Antineoplastic Agents; Benzenesulfonates; Carcinoma, Hepatocellular; Caspases; Cell Line, Tumor; Cell Survival; E2F1 Transcription Factor; Hep G2 Cells; Humans; Liver Neoplasms; NF-kappa B; Niacinamide; Organoplatinum Compounds; Oxaliplatin; Phenylurea Compounds; Pyridines; S-Adenosylmethionine; Sorafenib; Tumor Suppressor Protein p53

2012
Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity.
    Nature, 2014, Apr-10, Volume: 508, Issue:7495

    Topics: Acetyltransferases; Adipocytes; Adipose Tissue; Adipose Tissue, White; Animals; Diabetes Mellitus, Type 2; Diet; Energy Metabolism; Fatty Liver; Gene Knockdown Techniques; Glucose Intolerance; Glucose Transporter Type 4; Insulin Resistance; Liver; Male; Mice; Mice, Inbred C57BL; NAD; Niacinamide; Nicotinamide N-Methyltransferase; Obesity; Ornithine Decarboxylase; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; S-Adenosylmethionine; Sirtuin 1; Spermine; Thinness

2014
S-Adenosyl-L-methionine-competitive inhibitors of the histone methyltransferase EZH2 induce autophagy and enhance drug sensitivity in cancer cells.
    Anti-cancer drugs, 2015, Volume: 26, Issue:2

    Topics: Adenosine; Antineoplastic Combined Chemotherapy Protocols; Autophagy; Cell Line, Tumor; Cell Survival; Enhancer of Zeste Homolog 2 Protein; Enzyme Inhibitors; Gene Knockdown Techniques; Hep G2 Cells; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Humans; Indazoles; Niacinamide; Phenylurea Compounds; Polycomb Repressive Complex 2; Pyridones; S-Adenosylmethionine; Sorafenib

2015
The metabolome regulates the epigenetic landscape during naive-to-primed human embryonic stem cell transition.
    Nature cell biology, 2015, Volume: 17, Issue:12

    Topics: Animals; Blotting, Western; Cell Differentiation; Cells, Cultured; Embryonic Stem Cells; Epigenesis, Genetic; Gas Chromatography-Mass Spectrometry; Gene Expression Profiling; Gene Knockdown Techniques; Histones; Human Embryonic Stem Cells; Humans; Lysine; Mass Spectrometry; Metabolome; Metabolomics; Methylation; Mice; Niacinamide; Nicotinamide N-Methyltransferase; Proteomics; Reverse Transcriptase Polymerase Chain Reaction; S-Adenosylmethionine; Signal Transduction

2015
Crystal structures of monkey and mouse nicotinamide N-methyltransferase (NNMT) bound with end product, 1-methyl nicotinamide.
    Biochemical and biophysical research communications, 2017, 09-16, Volume: 491, Issue:2

    Topics: Amino Acid Sequence; Animals; Catalytic Domain; Cloning, Molecular; Crystallography, X-Ray; Escherichia coli; Feedback, Physiological; Gene Expression; Macaca mulatta; Mice; Models, Molecular; Niacinamide; Nicotinamide N-Methyltransferase; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Protein Structure, Tertiary; Recombinant Proteins; S-Adenosylmethionine; Sequence Alignment; Sequence Homology, Amino Acid; Substrate Specificity

2017
Kinetic Mechanism of Nicotinamide N-Methyltransferase.
    Biochemistry, 2018, 09-25, Volume: 57, Issue:38

    Topics: Humans; Kinetics; Methylation; NAD; Niacinamide; Nicotinamide N-Methyltransferase; S-Adenosylmethionine

2018
Canonical Wnt is inhibited by targeting one-carbon metabolism through methotrexate or methionine deprivation.
    Proceedings of the National Academy of Sciences of the United States of America, 2019, 02-19, Volume: 116, Issue:8

    Topics: Carbon; Endosomes; Glycogen Synthase Kinase 3 beta; HEK293 Cells; HeLa Cells; Humans; Lysosomes; Methionine; Methotrexate; Methylation; Niacinamide; Protein-Arginine N-Methyltransferases; Repressor Proteins; S-Adenosylmethionine; Wnt Signaling Pathway

2019
Proteomics reveals NNMT as a master metabolic regulator of cancer-associated fibroblasts.
    Nature, 2019, Volume: 569, Issue:7758

    Topics: Cancer-Associated Fibroblasts; Cell Line, Tumor; Cells, Cultured; Disease Progression; DNA Methylation; Female; Histones; Humans; Neoplasm Metastasis; Niacinamide; Nicotinamide N-Methyltransferase; Ovarian Neoplasms; Phenotype; Prognosis; Proteomics; S-Adenosylhomocysteine; S-Adenosylmethionine

2019
Evaluation of the Protective Effect of Ademetionine, Cytoflavin, and Dihydroquercetetine on Blood Enzymes Activity in Rats Treated with High Doses of Sodium Valproate.
    Bulletin of experimental biology and medicine, 2020, Volume: 170, Issue:2

    Topics: Alkaline Phosphatase; Animals; Anticonvulsants; Drug Combinations; Epilepsy; Erythrocytes; Flavin Mononucleotide; gamma-Glutamyltransferase; Inosine Diphosphate; Liver; Male; Niacinamide; Quercetin; Rats; S-Adenosylmethionine; Succinates; Time Factors; Valproic Acid

2020
Reduction of fatty liver in rats by nicotinamide via the regeneration of the methionine cycle and the inhibition of aldehyde oxidase.
    The Journal of toxicological sciences, 2021, Volume: 46, Issue:1

    Topics: Administration, Oral; Aldehyde Oxidase; Animals; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Enzyme Inhibitors; Hydralazine; Lipid Droplets; Liver; Male; Methionine; Niacinamide; Non-alcoholic Fatty Liver Disease; Rats, Sprague-Dawley; S-Adenosylmethionine; Triglycerides

2021
Lipopolysaccharide affects energy metabolism and elevates nicotinamide N-methyltransferase level in human aortic endothelial cells (HAEC).
    The international journal of biochemistry & cell biology, 2022, Volume: 151

    Topics: Chromatin; Endothelial Cells; Endothelium; Energy Metabolism; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipopolysaccharides; NAD; Niacinamide; Nicotinamide N-Methyltransferase; S-Adenosylmethionine

2022