niacinamide has been researched along with nicorandil in 520 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 168 (32.31) | 18.7374 |
| 1990's | 341 (65.58) | 18.2507 |
| 2000's | 5 (0.96) | 29.6817 |
| 2010's | 5 (0.96) | 24.3611 |
| 2020's | 1 (0.19) | 2.80 |
| Authors | Studies |
|---|---|
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Almeida, MO; Araujo, DP; César, IC; Coelho, MM; de Fátima, A; Dutra, MM; Godin, AM; Machado, RR; Menezes, RR; Oliveira, FC; Pianetti, GA; Santos, DA; Santos, JR | 1 |
| Satoh, K; Taira, N; Yanagisawa, T | 1 |
| Giles, TD; Hearron, AE; Karalis, DG; Mohrland, JS; Pina, IL; Porter, RS; Quiroz, AC; Roffidal, L; Wolf, DL; Zaleski, R | 1 |
| Auchampach, JA; Cavero, I; Gross, GJ | 1 |
| Buckley, MM; Fitton, A; Frampton, J | 1 |
| Holzmann, S; Kukovetz, WR; Pöch, G | 1 |
| Auch-Schwelk, W; Bossaller, C; Catadelgirmen, G; Ennker, J; Fleck, E; Graf, K; Gräfe, M | 1 |
| Berdeaux, A; Drieu la Rochelle, C; Giudicelli, JF; Richard, V | 1 |
| Auchampach, JA; Gross, GJ; Maruyama, M; Pieper, GM; Warltier, DC | 1 |
| Bassenge, E; Huckstorf, C | 1 |
| Frydman, A | 1 |
| MacLeod, D; Suryapranata, H | 1 |
| Erbel, R; Meyer, J; Treese, N | 1 |
| Beermann, C; Belz, GG | 1 |
| Bucx, JJ; Henneman, JA; Hugenholtz, PG; Kelder, JC; Kerker, JP; Meeter, K; Tijssen, JG | 1 |
| Diderholm, E; Frithz, G; Gudbrandsson, T; Hedbäck, B; Höglund, C; Moelstad, P; Perk, J; Sverrisson, JT; Ulvenstam, G | 1 |
| Döring, G | 1 |
| Kreye, VA; Lenz, T; Pfründer, D; Theiss, U | 1 |
| Bauters, C; Bertrand, ME; Lablanche, JM; Leroy, F | 1 |
| Wagner, G | 1 |
| Krumenacker, M; Roland, E | 1 |
| Lathrop, DA; Refsum, H; Tande, PM; Yang, T | 1 |
| Buggia, I; Iacona, I; Molinaro, M; Regazzi, MB; Rondanelli, R; Villani, P; Zoia, C | 1 |
| Kamata, K; Kasuya, Y; Miyata, N; Otomo, S; Tsuchida, K; Yamaura, H | 1 |
| Fang, D; Wu, Y | 1 |
| Gross, GJ; Pieper, GM | 4 |
| Braida, C; Holzmann, S; Kukovetz, WR; Pöch, G | 2 |
| Fukushima, H; Jinno, Y; Kasai, H; Nishikori, K; Ogawa, N; Ohta, H | 1 |
| Cook, D; Stockbridge, N; Vollrath, B; Weir, B; Zhang, H | 1 |
| Akima, M; Imagawa, J; Nabata, H; Taira, N | 1 |
| Fukata, Y; Fukushima, H; Jinno, Y; Kaneta, S; Nishikori, K; Ogawa, N | 1 |
| Belz, GG; Butzer, R; de Mey, C; Matthews, J; Schroeter, V | 1 |
| Araki, Y; Eto, K; Furuno, K; Gomita, Y; Mimaki, Y | 1 |
| Inoue, I; Nakaya, Y; Wakatsuki, T | 1 |
| Kinugawa, T; Kitamura, H; Kotake, H; Mashiba, H; Matsumoto, T; Miyakoda, H; Noguchi, N; Ogino, K | 1 |
| Baas, NR; van der Giessen, WJ; van Woerkens, LJ; Verdouw, PD | 1 |
| Ichihara, K; Nagasaka, M; Okumura, K | 1 |
| Asada, T; Higami, T; Kawamura, T; Mukohara, N; Nishiwaki, M; Ogawa, K; Okada, K; Sakata, M; Sugimoto, T | 1 |
| Bindley, PF; Binkley, PF; Jungbluth, GL; Leier, CV; MacKichan, JJ; Mohrland, JS; Tice, FD; Wolf, DL | 1 |
| Goto, Y; Hosokawa, J; Kanemoto, N; Kawai, K; Tagawa, R | 1 |
| Kau, ST; Li, JH; Zografos, P | 1 |
| Bokura, K; Kobayashi, S; Murao, M; Okada, K; Suyama, N; Yamaguchi, S | 1 |
| Kamijo, T; Kido, H; Miwa, A; Nakamura, F; Sugimoto, T; Tomaru, T; Uchida, Y | 1 |
| Arakawa, K; Handa, K; Ikeda, K; Kawasaki, K; Saeki, Y; Sasaki, J; Umeno, M | 1 |
| Benitah, JP; Coraboeuf, E; Deroubaix, E; Hatem, S; Le Grand, B; Le Heuzey, JY | 1 |
| Quast, U | 2 |
| Itoh, M; Miyamoto, T; Noguchi, Y; Yokochi, K | 1 |
| Matsuzaki, T; Sakanashi, M | 1 |
| Matthews, W; Pass, HI; Pogrebniak, HW | 1 |
| McPherson, GA; Stork, AP | 1 |
| Campa, PP; Dawodu, AA; Giglio, V; Lanti, M; Monti, F; Puddu, PE; Schiariti, M; Terracciano, CM | 1 |
| Andersson, KE | 1 |
| Molinaro, M; Regazzi, MB; Rondanelli, R; Salvadeo, A; Sartirana, E; Segagni, S; Villa, G | 1 |
| Hamilton, TC; Longman, SD | 1 |
| Hamaguchi, M; Imai, S; Ishibashi, T | 1 |
| Fujita, J; Hayashi, S; Horie, M; Kawai, C; Komori, M; Okada, Y; Suzuki, H; Zang, WJ | 1 |
| Cantor, E; Greenberg, SS; Ho, E; Walega, M | 1 |
| Borg, C; Cavero, I; Mestre, M; Mondot, S | 1 |
| Chiba, S; Horiuchi, A; Iwatsuki, K; Yonekura, H | 1 |
| Henry, PJ; Horowitz, JD; Louis, WJ | 1 |
| Grover, GJ; Parham, CS; Sleph, PG | 1 |
| Flavahan, NA; Morrison, KJ; Vanhoutte, PM | 1 |
| Cipkus-Dubray, LA; Hosner, JM; Khan, SA; Meisheri, KD | 1 |
| Berdeaux, A; Giudicelli, JF; Richer, C | 1 |
| Higuera, TR; Kadowitz, PJ; Kvamme, P; Minkes, RK; Nossaman, BD | 1 |
| Kreye, VA; Lenz, T; Theiss, U | 1 |
| Satoh, K; Taira, N; Yamada, H | 1 |
| Gomita, Y; Oishi, R; Yamori, M | 1 |
| Hashimoto, K; Kinoshita, M; Ohbayashi, Y | 2 |
| Akahane, K; Chiba, S; Furukawa, Y; Ogiwara, Y | 1 |
| Morimoto, Y; Sato, K; Sugibayashi, K | 1 |
| Ksoll, E; Mackert, JR; Parsons, AA; Schilling, L; Wahl, M | 1 |
| Arakawa, C; Kasuya, Y; Masuda, Y; Miyajima, M; Shigenobu, K; Tanaka, S; Yamashita, T | 1 |
| Tanaka, H | 1 |
| Ikegaki, I; Nakanishi, T; Nishimura, M; Sakamoto, M; Takahashi, H; Yoshimura, M | 1 |
| Goto, S; Kitagaki, K; Koda, A; Nagai, H; Suda, H | 1 |
| Abe, H; Fukasawa, M; Hirooka, S; Kuraoka, S; Orita, H; Shimanuki, T; Washio, M | 2 |
| Arita, M; Ito, M; Saikawa, T; Takahashi, N | 1 |
| Chibana, T; Mimura, G; Murakami, K; Nagamine, F; Nakada, Y; Oshiro, K; Sakanashi, M; Shimabukuro, M; Shinzato, T; Sunagawa, R | 1 |
| Fan, Z; Hiraoka, M; Marumo, F; Nakayama, K; Sawanobori, T | 1 |
| Kurachi, Y; Machulda, MM; Shen, WK; Tung, RT | 1 |
| Sheng, BH; Zhang, YM; Zhao, DH | 2 |
| Fukuma, N; Hata, N; Hayakawa, H; Kishida, H; Saito, T; Tada, Y; Tetsuoh, Y; Yamazaki, Y; Yasutake, M | 1 |
| Fukamachi, K; Fukumura, F; Kinoshita, K; Kurisu, K; Mitani, A; Nakashima, A; Sakamoto, M; Tokunaga, K; Tsuruhara, Y | 1 |
| Abe, H; Fukasawa, M; Hirooka, S; Inui, K; Orita, H; Washio, M | 1 |
| Cavero, I; Mondot, S; Pratz, J | 1 |
| Cadeddu, M; Cherchi, A; Lai, C; Lai, G; Onnis, E; Orani, E; Solinas, R | 1 |
| Stockbridge, N; Weir, B; Zhang, H | 1 |
| Fukushima, H; Harada, K; Jinno, Y; Nishikori, K; Ogawa, N; Ohta, H | 1 |
| Satoh, K; Taira, N; Yamada, H; Yoneyama, F | 2 |
| Hirabayashi, M; Ikegaki, I; Matsusawa, M; Nakanishi, T; Nishimura, M; Takahashi, H; Yoshimura, M | 1 |
| Hosoda, S; Uchida, T | 1 |
| Binetti, G; Boriani, G; Boschi, S; Galié, N; Magnani, B; Maiello, L; Varani, E | 1 |
| Lathrop, DA; Nànàsi, PP; Varrò, A | 1 |
| Lewis, RC; Schwende, FJ | 1 |
| Binkley, PF; Cody, RJ; Leier, CV; Moeschberger, ML; Mohrland, JS; Tice, FD; Wolf, DL | 1 |
| Hata, N; Iwahara, S; Kishida, H; Koumi, S; Kusama, Y; Mori, N; Munakata, K; Sasaki, Y; Takayama, M; Yasutake, M | 1 |
| Colatsky, T; Follmer, C; Parsons, R; Spinelli, W | 1 |
| Araki, Y; Eto, K; Fukuda, T; Furuno, K; Gomita, Y; Oishi, R; Yamori, M | 1 |
| Kajioka, S; Kitamura, K; Oike, M | 1 |
| Hughes, LO; Lahiri, A; Raftery, EB; Rose, EL | 2 |
| Amioka, H; Hashimoto, M; Kajiyama, G; Matsuura, H; Okamoto, M; Tsuchioka, Y; Yamagata, T | 1 |
| Ishikawa, S; Kojima, S; Mori, H; Ohsawa, K | 1 |
| Araki, Y; Eto, K; Furuno, K; Gomita, Y | 1 |
| Taira, N; Teshigawara, T; Yanagisawa, T | 1 |
| Inagaki, H; Matsunami, T; Sotobata, I; Tsuzuki, J; Watanabe, M; Yokota, M | 1 |
| Satoh, E; Taira, N; Yanagisawa, T | 1 |
| Fukuo, K; Imanaka, S; Kim, S; Kitano, S; Koh, E; Miyashita, Y; Morimoto, S; Morita, R; Ogihara, T | 1 |
| Kinoshita, M; Sakai, K | 1 |
| Satoh, K; Taira, N; Yoneyama, F | 1 |
| Chen, SL; Feng, XB; Li, LS; Zang, YM; Zhu, MZ | 1 |
| Noma, A; Takano, M | 1 |
| Dunne, MJ | 1 |
| Furukawa, K; Kitamura, K; Yamanaka, K | 1 |
| Allen, SL; Foster, RW; Morgan, GP; Small, RC | 1 |
| Bolton, TB; Clapp, LH | 1 |
| Weir, SW; Weston, AH | 2 |
| Akiyama, H; Kobayashi, I; Kobayashi, S; Mori, M; Shiono, S; Yamada, M; Yamaguchi, M | 1 |
| Kato, A; Nakamura, F; Sugimoto, T; Sumino, S; Tomaru, T; Uchida, Y | 1 |
| Kakei, M; Saito, K; Tanaka, H; Yoshinaga, M | 1 |
| Muramatsu, I; Noda, M | 1 |
| Iijima, T; Taira, N | 2 |
| Bouthier, JA; Laurent, S; Levenson, JA; London, GM; Safar, ME | 1 |
| Coldwell, MC; Howlett, DR | 1 |
| Karaki, H; Murakami, K; Urakawa, N | 1 |
| Gross, GJ; Hardman, HF; Warltier, DC | 1 |
| Taira, N | 2 |
| Imai, S; Katano, Y; Nabata, H; Nakagawa, Y; Nakazawa, M; Takeda, K; Tsukada, T; Ushijima, T | 1 |
| Kambara, H; Kawai, C; Nakamura, Y; Tamaki, S | 2 |
| Hakuta, T; Kobayashi, K | 1 |
| Horisawa, T; Iwase, M; Kamihara, S; Koide, M; Miyahara, T; Noda, S; Tsunekawa, A; Tsuzuki, M; Yokota, M; Yoshida, J | 1 |
| Aizawa, T; Kato, K; Ogasawara, K | 1 |
| Kuromaru, O; Sakai, K | 4 |
| Holzmann, S; Kukovetz, WR | 1 |
| Fukuo, K; Hironaka, T; Imanaka, S; Itoh, K; Koh, E; Kumahara, Y; Morimoto, S; Onishi, T; Shiraishi, T; Yamamoto, H | 1 |
| Satake, N; Shibata, S | 2 |
| Becker, EJ; Hester, RK; O'Connor, DE | 1 |
| Sugimoto, T; Uchida, Y | 1 |
| Weston, AH | 1 |
| Casteels, R; Droogmans, G; Kajiwara, M | 2 |
| Domae, M; Hashimoto, T; Kitamura, K; Kuriyama, H; Nakao, K; Sumimoto, K; Yamanaka, K | 1 |
| Gross, GJ; Pieper, GM; Warltier, DC | 1 |
| Abiko, Y; Ichihara, K; Sakai, K | 1 |
| Abe, S; Hattori, S; Kojima, S; Miyamori, R; Miyazaki, T; Mori, H; Nakamura, Y; Sakurai, K; Takahashi, M | 1 |
| Asanoi, H; Hosoda, S; Hosono, K; Ishida, K; Kato, K; Kurita, A; Kuroiwa, A; Seki, K; Shiina, A; Wakabayashi, C | 1 |
| Ishii, K; Sato, Y; Taira, N | 1 |
| Lefer, AM; Lefer, DJ | 1 |
| Clapham, JC; Hamilton, TC; Longman, SD; Wilson, C | 1 |
| Endo, T; Fujita, S; Hayakawa, H; Kikuchi, K; Kiuchi, K; Nejima, J; Okumura, H | 1 |
| Ajioka, M; Fukushima, A; Hanaki, Y; Kondo, T; Ozawa, T; Sugiyama, S | 1 |
| Lathrop, DA; Varró, A | 1 |
| Hamilton, TC; Weston, AH | 1 |
| Haneda, T; Ichihara, K; Onodera, S | 1 |
| Farber, NE; Gross, G; Hardman, H; Pieper, G; Warltier, D | 1 |
| Sakai, K | 1 |
| Bouthier, J; Bruno, R; Caplain, H; Chapelle, P; Diekmann, H; Frydman, AM; Gaillard, C; Le Liboux, A; Thebault, JJ; Ungethuem, W | 1 |
| Coltart, DJ; Signy, M | 1 |
| Bouthier, J; Chau, NP; Levenson, J; Roland, E; Simon, AC | 1 |
| Bouthier, J; Dahan, M; Gourgon, R; Jaeger, P; Juliard, JM; Solal, AC | 1 |
| Ali, MS; Goldhammer, E; Silke, B; Taylor, SH; Verma, SP | 1 |
| Camm, AJ; Maltz, MB | 1 |
| Camm, AJ; Coltart, J; Griffith, M; Maltz, MB; Meany, TB; Richardson, P; Signy, M | 1 |
| Hashimoto, K; Inoue, T; Kinoshita, M; Mitsunami, K; Ohbayashi, Y; Taguchi, H | 1 |
| Aizawa, T; Hirosaka, A; Kato, K; Nagashima, K; Nakamura, F; Ogasawara, K; Sakuma, T | 1 |
| Serruys, PW; Suryapranata, H | 1 |
| Hawgood, BJ; Kempsford, RD | 1 |
| Fan, Z; Hiraoka, M | 1 |
| Hironaka, T; Kim, S; Koh, E; Morimoto, S; Morita, R; Nabata, T; Ogihara, T; Onishi, T; Takamoto, S | 1 |
| Hashimoto, H; Taira, N; Yanagisawa, T | 2 |
| Eltze, M | 1 |
| Garrino, MG; Henquin, JC; Plant, TD | 2 |
| Kamata, K; Kasuya, Y; Miyata, N | 1 |
| Araki, Y; Furuno, K; Gomita, Y; Yamori, M | 1 |
| Hayashi, J; Kasahara, M; Manabe, H; Ohni, M; Watanabe, Y | 1 |
| Fujimoto, M; Kitao, T; Kohara, H; Kumahara, Y; Morimoto, K; Ogihara, T; Ohde, H; Tai, H; Terada, K | 1 |
| Bolla, GB; Chianca, R; Fruscio, M; Gradnik, R; Leonetti, G; Prandi, P; Zanchetti, A | 1 |
| Heere, TJ; Sassen, LM; Saxena, PR; Soei, LK; van Woerkens, LJ; Verdouw, PD | 1 |
| Aihara, T; Bando, M; Hamai, K; Hiasa, Y; Kataoka, Y; Nakai, Y; Wada, T | 1 |
| Ban, T; Hamamoto, T; Kojima, M | 1 |
| Kai, H; Kanaide, H; Nakamura, M | 1 |
| Enomoto, N; Morimoto, Y; Omiya, H; Sato, K; Sugibayashi, K | 1 |
| Geshi, E; Hiroshige, J; Katagiri, T; Konno, N; Mochizuki, M; Umetsu, K | 1 |
| Hester, RK | 1 |
| Coldwell, MC; Cooper, SM; Hamilton, TC; Howlett, DR; Wilson, C | 1 |
| Kukovetz, WR; Reich, R; Schmidt, K | 1 |
| Flores, F; Hester, RK; Satake, N; Shibata, S; Ueda, S | 1 |
| Brooks, HL; Gross, GJ; Warltier, DC; Wynsen, JC | 1 |
| Hinohara, Y; Homma, N; Kuromaru, O; Sakai, K; Yamazaki, T | 1 |
| Trendelenburg, U | 1 |
| Ito, Y; Obara, K | 1 |
| Kukovetz, WR; Romanin, C | 1 |
| Karaki, H; Murakami, K; Nakagawa, H; Uragawa, N | 1 |
| Fujiwara, M; Muramatsu, I | 1 |
| Ogawa, N; Ono, H | 1 |
| Bito, K; Itoh, M; Kawakita, S; Kinoshita, M; Mashiro, I; Mitsunami, K; Motomura, M; Nishikawa, S; Sawamura, M; Yamaguchi, S | 1 |
| Ito, H; Kato, T; Nakasone, J; Noguchi, K; Sakanashi, M; Sunagawa, R | 1 |
| Araki, H; Hayata, N; Nakamura, M | 1 |
| Brooks, HL; Gross, GJ; Preuss, KC; Shimshak, TM; Warltier, DC | 1 |
| Imai, S; Matsui, K; Ogawa, Y | 1 |
| Hader, S; Leitold, M | 1 |
| Ikeda, K; Imai, S; Ito, M; Joh, T; Katsumi, K; Matsusako, K; Miyamoto, T; Takeuchi, T; Yasue, N; Yokoyama, Y | 1 |
| Araki, H; Hayata, N; Matsuguchi, T; Nakamura, M | 1 |
| Kishida, H; Murao, S | 1 |
| Habuchi, Y; Nishimura, M; Watanabe, Y | 1 |
| Dernbach, P; Harder, DR; Waters, A | 1 |
| Endoh, M; Iijima, T; Taira, N | 1 |
| Duncker, DJ; Rensen, RJ; Sassen, LM; Saxena, PR; Schmeets, IO; Verdouw, PD | 1 |
| Fang, KQ; Sheng, BH; Zhao, DH | 1 |
| Clapham, JC; Wilson, C | 1 |
| Hattori, S; Kojima, S; Miyamori, R; Miyazaki, T; Mori, H; Nagata, M; Nakamura, Y; Takahashi, M | 1 |
| De Feyter, PJ; Hugenholtz, PG; Serruys, PW; Suryapranata, H; Verdouw, PD | 1 |
| Ohba, Y; Sakai, K; Shiraki, Y | 1 |
| Hayashi, Y; Nakamura, M; Nishijima, H; Tomoike, H; Yamada, A | 1 |
| Ban, T; Kojima, M | 1 |
| Irié, H | 1 |
| Kitamura, K; Kuriyama, H; Nakao, K; Okabe, K; Weston, AH | 1 |
| Abe, H; Fukasawa, M; Inui, K; Kobayashi, M; Kuraoka, S; Orita, H; Shimanuki, T; Washio, M | 1 |
| Morimoto, Y; Oda, T; Sato, K; Sugibayashi, K | 1 |
| Hashimoto, T; Kaguchi, Y; Kimura, M; Kuriyama, S; Miyahara, T; Nakamura, K; Tamai, K; Tamura, H | 1 |
| Iwaki, M; Kawano, K; Mizobuchi, S; Mori, H; Nakaya, S; Nakaya, Y | 1 |
| Ozawa, T; Satake, T; Sugiyama, S; Suzuki, K; Takagi, K | 1 |
| Kigoshi, S; Muramatsu, I; Nishio, M | 1 |
| Uchida, Y | 1 |
| Ishii, K; Satoh, K; Taira, N; Yanagisawa, T | 1 |
| Nakamura, Y; Sakai, K; Sugimoto, T; Yamazaki, T | 1 |
| Miyazaki, Y; Ogawa, K; Ozawa, T; Satake, T; Sugiyama, S | 1 |
| Hellige, G; Hoeft, A; Hunneman, DH; Korb, H; Schraeder, R; Wolpers, HG | 1 |
| Akima, M; Hinohara, Y; Obatake, N; Sakai, K | 1 |
| Itoh, T; Karashima, T; Kuriyama, H | 1 |
| Higuchi, M; Rokutanda, M; Sakanashi, M; Takeo, S | 1 |
| Ban, M; Enomoto, I; Hashimoto, H; Ito, T; Ogawa, K; Sakai, K | 1 |
| Maruyama, M; Satoh, K; Taira, N | 1 |
| Gottwik, M; Kramer, W; Schlepper, M; Thormann, J | 1 |
| Aniya, Y; Higuchi, M; Miyamoto, Y; Sakanashi, M; Takeo, S | 1 |
| Akima, M; Hoshino, E; Sakai, K; Shiraki, Y | 1 |
| Imai, S; Nabata, H; Nakazawa, M; Sakai, K; Ushijima, T | 1 |
| Nabata, H; Sakai, K | 1 |
| Abiko, Y; Nishimura, T; Sakai, K | 1 |
| Gross, GJ; Hardman, HF; Lamping, KA; Warltier, DC | 1 |
| Hirakawa, S; Ito, H | 1 |
| Chiba, K; Ishizaki, T; Kamiyama, H; Nakano, H; Sasaki, T; Suganuma, T | 1 |
| Fujisawa, K; Inoue, T; Itoh, T; Kanmura, Y; Kuriyama, H | 1 |
| Nabata, H; Nakamura, Y; Sakai, K; Shiraki, Y | 1 |
| Hashimoto, K; Satoh, H | 1 |
| Kerfoot, F; Satake, N; Shibata, S; Suh, TK; Takagi, T | 1 |
| Maruyama, M; Satoh, K; Taira, N; Yamashita, S | 1 |
| Belz, GG; Heinrich, J; Matthews, J; Wagner, G | 1 |
| Kobayashi, A; Ogawa, K; Yamazaki, N | 1 |
| Endoh, M; Taira, N; Yanagisawa, T | 1 |
| Furukawa, K; Ito, Y; Itoh, T; Kajiwara, M; Kitamura, K; Kuriyama, H; Suzuki, H | 2 |
| Aomine, M; Arita, M; Imanishi, S; Kiyosue, T | 1 |
| Endoh, M; Taira, N | 1 |
| Inoue, T; Ito, Y; Takeda, K | 1 |
| Kubodera, N; Neichi, T; Tomisawa, S; Uchida, Y | 1 |
| Taira, N; Yanagisawa, T | 2 |
| Akima, M; Hinohara, Y; Kamiyama, H; Nakano, H; Ohba, Y; Sakai, K | 1 |
| Inouh, T; Kikuchi, Y; Mizukami, M; Nakamura, M; Tomoike, H; Watanabe, K | 1 |
| Inou, T | 1 |
| Aono, J; Haruta, K; Sakai, K | 1 |
| Akima, M; Aono, J; Sakai, K | 1 |
| Isono, C; Ogawa, K; Wada, S | 1 |
| Akima, M; Hoshino, E; Nabata, H; Ohba, Y; Sakai, K; Shiraki, Y | 1 |
| Aizawa, Y; Chinushi, M; Furushima, H; Inuzuka, H; Ojima, K; Shibata, A | 1 |
| Galiñanes, M; Hearse, DJ; Qiu, Y | 1 |
| Satoh, H | 2 |
| Francis, S; Jaraki, O; Loscalzo, J; Stamler, JS; Strauss, WE | 1 |
| Kinoshita, M; Nakae, I; Quan, L; Sugimoto, Y; Tsutamoto, T | 1 |
| Klein, HH; Lindert-Heimberg, S; Maisch, B; Nebendahl, K; Pich, S; Schade-Brittinger, C | 1 |
| Hisatome, I; Kato, M; Kinugawa, T; Kitamura, H; Matsumoto, T; Miyakoda, H; Noguchi, N; Ogino, K; Omodani, H; Osaki, S | 1 |
| Hirota, Y; Ito, T; Kawamura, K; Kusukawa, J; Otake, Y; Suwa, M | 1 |
| Kawai, A | 1 |
| Abe, H; Matsuda, T; Mori, H; Oyanagi, S | 1 |
| Attolini, L; Bruguerolle, B; Gantenbein, M | 3 |
| Berwing, K; Mitrovic, V; Schlepper, M; Strasser, R; Thormann, J | 1 |
| Baumbach, A; Braun, U; Döring, G; Haase, KK; Karsch, KR; Voelker, W | 1 |
| Kaski, JC | 1 |
| Fox, K; Knight, C; Purcell, H | 1 |
| Darmon, JY; Witchitz, S | 1 |
| Fukui, T; Hibiya, K; Honye, J; Kamata, T; Mizumura, T; Moriuchi, M; Ozawa, Y; Saito, S; Takayama, T; Tamura, Y | 1 |
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| Fukushima, H; Jinno, Y; Kaneta, S; Miwa, A; Ogawa, N | 1 |
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| Branzi, A; Galiè, N; Guarnieri, C; Magnani, B; Parlangeli, R; Traini, AM; Ussia, GP; Vaona, I; Zimarino, M | 1 |
| Mizoguchi, K; Tanaka, M; Tanaka, T; Yokoo, H; Yoshida, M | 2 |
| Chiang, CH; Lin, CH | 1 |
| Asanagi, M; Mitamura, H; Miyazaki, T; Miyoshi, S; Moritani, K; Ogawa, S; Zhao, LS | 1 |
| Ejima, J; Fujino, T; Kaji, Y; Kanaya, S; Kaneda, K; Maruyama, T; Moriyama, H; Niho, Y; Ohmura, I; Tsuda, Y | 1 |
| Humphrey, SJ; Schwende, FJ | 1 |
| Gu, K; Kin, S; Nakayama, K; Nosaka, S; Saitoh, Y; Sasaki, T; Yamauchi, M | 2 |
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| Hara, Y; Kimura, S; Kobayashi, S; Masuda, Y; Nakaya, H; Saito, T; Takizawa, T | 1 |
| Wang, HX; Wang, WX | 1 |
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| Miyazaki, T; Miyoshi, S; Moritani, K; Ogawa, S | 1 |
| Hayashi, H; Katoh, H; McDonald, TF; Terada, H | 1 |
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| Jahangir, A; Jahangir, R; López, JR; Shen, WK; Terzic, A | 1 |
| Györgyi, K; Papp, JG; Parratt, JR; Sakai, K; Vegh, A | 1 |
| Asayama, J; Katamura, M; Kawahara, A; Kobara, M; Matoba, S; Nakagawa, C; Nakagawa, M; Ohta, B; Tanaka, T; Tatsumi, T; Tsuruyama, K | 1 |
| Bergamaschi, M; Gromo, G; Mizrahi, J; Nonaka, K; Ueno, A | 1 |
| Frishman, WH; Goldschmidt, M; Landzberg, BR | 1 |
| Grover, GJ | 2 |
| Fujita, H; Iwahashi, M; Kim, S; Maeda, K; Namura, H; Yamabe, H; Yano, T; Yokoyama, M | 1 |
| Sunamori, M; Wang, Y; Yoshida, T | 1 |
| Cooper, JD; Fujino, S; Patterson, GA; Schmid, RA; Yamashita, M | 1 |
| Chujo, M; Hori, M; Inoue, M; Kamada, T; Kitakaze, M; Komamura, K; Minamino, T; Mori, H; Node, K; Shinozaki, Y | 1 |
| Aonuma, K; Hiroe, M; Igawa, M; Inada, M; Korenaga, M; Marumo, F; Ogawara, S; Okamoto, Y; Umezawa, S | 1 |
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| Karaki, H; Mitsui-Saito, M; Ozaki, H; Trongvanichnam, K | 1 |
| Hara, Y; Masuda, Y; Nakaya, H; Saito, T; Takizawa, T | 1 |
| Brixius, K; Hoischen, S; Müller-Ehmsen, J; Schwinger, RH | 1 |
| Angus, JA; Fujiwara, T | 1 |
| Brading, AF; Teramoto, N | 1 |
| Iinuma, F; Mawatari, K; Nakamura, Y; Sate, S; Shimizu, R; Watanabe, M | 1 |
| Chiariello, M; Perrone Filardi, P | 1 |
| Bona, M; Marsico, F; Micheletti, T; Specchia, G | 1 |
| Aya, G; de La Coussaye, JE; Delye, B; Eledjam, JJ; Juan, JM; Péray, P; Robert, E; Sassine, A | 1 |
| Gerson, C | 1 |
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| Hanaoka, K; Hayashida, M; Ito, N; Kawamura, S; Komatsu, K; Kuzumi, E; Orii, R; Sawamura, S | 1 |
| Horio, Y; Isomoto, S; Kondo, C; Kurachi, Y; Matsumoto, S; Shindo, T; Yamada, M | 1 |
| Carr, C; Montgomery, H; Singer, M; Sumeray, M | 1 |
| Chujo, M; Critz, SD; Downey, JM; Liu, GS | 1 |
| Bedane, C; Bonnetblanc, JM; Boulinguez, S; Bouyssou-Gauthier, ML; Cornée-Leplat, I; Truong, E | 1 |
| Hasegawa, S; Hirayama, A; Ishikura, F; Kodama, K; Komamura, K; Sakata, Y | 1 |
| Hirayama, A; Hori, M; Ishikura, F; Kitakaze, M; Kodama, K; Komamura, K; Lim, YJ; Masuyama, T; Sakata, Y | 1 |
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| Chang, MS; Chen, JW; Hsu, NW; Lee, WL; Lin, SJ; Ting, CT; Wang, SP | 1 |
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| Kinoshita, M; Liu, Q; Matsumoto, T; Nakae, I; Omura, T; Takahashi, M; Takaoka, A | 1 |
| Demiryürek, AT; Kane, KA; Kennedy, S; Wadsworth, RM; Wainwright, CL | 1 |
| Evans, R; Foex, P; Pigott, D; Piriou, V; Ross, S | 1 |
| Aarsland, T; Dickstein, K; Gøransson, L; Larsen, AI; Tamby, JF | 1 |
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| Hori, M; Horio, Y; Isomoto, S; Kitakaze, M; Kondo, C; Kurachi, Y; Okuyama, Y; Satoh, E; Shindo, T; Yamada, M | 1 |
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34 review(s) available for niacinamide and nicorandil
| Article | Year |
|---|---|
Nicorandil. A review of its pharmacology and therapeutic efficacy in angina pectoris.
Topics: Angina Pectoris; Animals; Biological Availability; Drug Interactions; Drug Tolerance; Hemodynamics; Humans; Niacinamide; Nicorandil; Nitrates; Potassium Channels; Vasodilator Agents | 1992 |
Acute hemodynamic effects of nicorandil in coronary artery disease.
Topics: Animals; Coronary Disease; Dogs; Hemodynamics; Humans; Niacinamide; Nicorandil; Vasodilator Agents | 1992 |
Clinical profile of nicorandil: an overview of its hemodynamic properties and therapeutic efficacy.
Topics: Diltiazem; Hemodynamics; Humans; Myocardial Ischemia; Niacinamide; Nicorandil; Potassium Channels; Vasodilator Agents | 1992 |
[Advance in pharmacology of potassium channels in cardiovascular system and their clinical use].
Topics: Benzopyrans; Cromakalim; Guanidines; Humans; Muscle, Smooth, Vascular; Myocardium; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Vasodilator Agents | 1992 |
Potassium channel openers: pharmacological and clinical aspects.
Topics: Animals; Benzopyrans; Cardiovascular Diseases; Cromakalim; Heart; Humans; Muscle, Smooth; Nervous System; Niacinamide; Nicorandil; Potassium Channels; Pyrroles; Vasodilator Agents | 1992 |
Clinical pharmacology of potassium channel openers.
Topics: Antihypertensive Agents; Benzopyrans; Cardiovascular System; Cromakalim; Guanidines; Humans; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Respiratory System | 1992 |
Potassium channel activator drugs: mechanism of action, pharmacological properties, and therapeutic potential.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Cardiovascular System; Central Nervous System; Clinical Trials as Topic; Cromakalim; Disease Models, Animal; Guanidines; Humans; Muscle, Smooth, Vascular; Muscles; Neurons; Niacinamide; Nicorandil; Pancreas; Pinacidil; Potassium Channels; Pyrroles; Vasodilator Agents | 1992 |
Pharmacology and therapeutic effects of nicorandil.
Topics: Angina Pectoris; Animals; Coronary Vessels; Drug Interactions; Hemodynamics; Humans; Niacinamide; Nicorandil; Vasodilator Agents | 1990 |
Similarity and dissimilarity in the mode and mechanism of action between nicorandil and classical nitrates: an overview.
Topics: Animals; Arteries; Coronary Vessels; Cyclic GMP; Heart; Hemodynamics; Ion Channels; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitrates; Potassium; Vasodilator Agents; Veins | 1987 |
Actions of nicorandil on vascular smooth muscles.
Topics: Action Potentials; Animals; Calcium; Cyclic GMP; In Vitro Techniques; Ion Channels; Membrane Potentials; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitroglycerin; Vasoconstriction; Vasodilator Agents | 1987 |
Cromakalim, nicorandil and pinacidil: novel drugs which open potassium channels in smooth muscle.
Topics: Animals; Guanidines; Humans; Niacinamide; Nicorandil; Pinacidil; Potassium Channels | 1989 |
Effects of nicorandil on coronary circulation and myocardial ischemia.
Topics: Animals; Coronary Circulation; Coronary Disease; Dogs; Niacinamide; Nicorandil; Vasodilator Agents | 1989 |
Nicorandil as a hybrid between nitrates and potassium channel activators.
Topics: Animals; Dogs; Niacinamide; Nicorandil; Nitroglycerin; Potassium Channels; Stimulation, Chemical; Vasodilator Agents | 1989 |
Nicorandil: animal pharmacology.
Topics: Angina Pectoris; Animals; Coronary Vasospasm; Dogs; Drug Tolerance; Niacinamide; Nicorandil; Vasodilator Agents | 1989 |
Effects of nicorandil on regional perfusion and left ventricular function.
Topics: Animals; Anti-Arrhythmia Agents; Coronary Circulation; Echocardiography; Humans; Myocardial Ischemia; Niacinamide; Nicorandil; Regional Blood Flow; Ventricular Function, Left | 1995 |
Management of vasospastic angina--role of nicorandil.
Topics: Angina Pectoris; Anti-Arrhythmia Agents; Coronary Vasospasm; Humans; Niacinamide; Nicorandil | 1995 |
Potassium channel openers: clinical applications in ischemic heart disease--overview of clinical efficacy of nicorandil.
Topics: Angina Pectoris; Animals; Anti-Arrhythmia Agents; Hemodynamics; Humans; Myocardial Ischemia; Niacinamide; Nicorandil; Potassium Channels | 1995 |
Pharmacologic therapy of angina pectoris.
Topics: Acetanilides; Adrenergic beta-Antagonists; Angina Pectoris; Aspirin; Calcium Channel Blockers; Drug Therapy, Combination; Enoximone; Heparin; Humans; Isosorbide Dinitrate; Niacinamide; Nicorandil; Nitroglycerin; Piperazines; Ranolazine; Vasodilator Agents | 1995 |
Pharmacology and structure-activity relationships for KATP modulators: tissue-selective KATP openers.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Antihypertensive Agents; Benzopyrans; Cardiovascular Diseases; Cromakalim; Diazoxide; Guanidines; Guinea Pigs; Minoxidil; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Picolines; Pinacidil; Potassium Channels; Pyrans; Pyrroles; Radioligand Assay; Rats; Structure-Activity Relationship; Vasodilator Agents | 1994 |
Cerebral vascular smooth muscle potassium channels and their possible role in the management of vasospasm.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Calcium; Cromakalim; Electrophysiology; Guanidines; Ischemic Attack, Transient; Muscle, Smooth, Vascular; Neuropeptides; Niacinamide; Nicorandil; Nitric Oxide; Pinacidil; Potassium Channels; Pyrroles; Vasoconstriction; Vasodilator Agents | 1994 |
Prescribing for angina.
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Aspirin; Calcium Channel Blockers; Humans; Myocardial Ischemia; Niacinamide; Nicorandil; Nitrates; Vasodilator Agents | 1994 |
Therapeutic potential of potassium channel activators in coronary heart disease.
Topics: Animals; Coronary Disease; Coronary Vessels; Heart; Humans; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Potassium Channels; Vasodilator Agents | 1994 |
[Anti-angina activity of potassium-channel activators].
Topics: Angina Pectoris; Clinical Trials as Topic; Coronary Disease; Humans; Niacinamide; Nicorandil; Potassium Channels | 1993 |
[Potassium agonists].
Topics: Animals; Benzopyrans; Calcium; Cromakalim; Humans; Membrane Potentials; Muscle, Smooth, Vascular; Myocardial Ischemia; Neuromuscular Junction; Niacinamide; Nicorandil; Potassium; Potassium Channels; Pyrroles; Vascular Resistance; Vasodilator Agents | 1994 |
Do the K+ channel openers relax smooth muscle by opening K+ channels?
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Calcium; Cromakalim; Humans; Inositol 1,4,5-Trisphosphate; Membrane Potentials; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Potassium; Potassium Channels; Pyrroles; Vasodilator Agents | 1993 |
[Ca-antagonist, K-channel-opener in the treatment of patients with congestive heart failure].
Topics: Animals; Benzopyrans; Calcium Channel Blockers; Cromakalim; Guanidines; Heart Failure; Hemodynamics; Humans; In Vitro Techniques; Ion Channel Gating; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Vasodilator Agents | 1993 |
[Potential role of ATP-sensitive K+ channels in ischemia- and reperfusion-induced arrhythmias].
Topics: Action Potentials; Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Benzopyrans; Cromakalim; Glyburide; Guanidines; Humans; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Niacinamide; Nicorandil; Pinacidil; Potassium; Potassium Channels; Pyrroles; Tolbutamide | 1993 |
Coronary haemodynamics and vasodilatory profile of a potassium channel opener in patients with coronary artery disease.
Topics: Administration, Sublingual; Coronary Circulation; Coronary Disease; Dose-Response Relationship, Drug; Hemodynamics; Humans; Myocardial Ischemia; Niacinamide; Nicorandil; Potassium Channels; Vasodilation; Vasodilator Agents | 1993 |
Potassium channel activators in vasospastic angina.
Topics: Angina Pectoris, Variant; Animals; Coronary Angiography; Coronary Circulation; Coronary Vasospasm; Humans; Niacinamide; Nicorandil; Potassium Channels; Vasodilator Agents | 1993 |
A potassium channel opener as monotherapy in chronic stable angina pectoris: comparison with placebo.
Topics: Angina Pectoris; Coronary Circulation; Coronary Disease; Dose-Response Relationship, Drug; Exercise Test; Humans; Niacinamide; Nicorandil; Potassium Channels; Vasodilator Agents | 1993 |
Haemodynamic and clinical effects of an intravenous potassium channel opener--a review.
Topics: Administration, Sublingual; Angina, Unstable; Coronary Circulation; Coronary Disease; Hemodynamics; Humans; Infusions, Intravenous; Isosorbide Dinitrate; Niacinamide; Nicorandil; Nitroglycerin; Potassium Channels; Vasodilator Agents | 1993 |
Nicorandil for angina.
Topics: Angina Pectoris; Humans; Niacinamide; Nicorandil; Vasodilator Agents | 1995 |
Nicorandil: a potassium channel opening drug for treatment of ischemic heart disease.
Topics: Clinical Trials as Topic; Coronary Disease; Hemodynamics; Humans; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Potassium Channels; Vasodilator Agents | 1996 |
Pharmacology of ATP-sensitive potassium channel (KATP) openers in models of myocardial ischemia and reperfusion.
Topics: Animals; ATP-Binding Cassette Transporters; Benzopyrans; Cromakalim; Guanidines; Humans; Ischemic Preconditioning, Myocardial; KATP Channels; Mitochondria, Heart; Models, Cardiovascular; Myocardial Ischemia; Myocardial Reperfusion; Niacinamide; Nicorandil; Picolines; Pinacidil; Potassium Channels; Potassium Channels, Inwardly Rectifying; Pyrans; Pyrroles; Rats | 1997 |
54 trial(s) available for niacinamide and nicorandil
| Article | Year |
|---|---|
Nicorandil. A review of its pharmacology and therapeutic efficacy in angina pectoris.
Topics: Angina Pectoris; Animals; Biological Availability; Drug Interactions; Drug Tolerance; Hemodynamics; Humans; Niacinamide; Nicorandil; Nitrates; Potassium Channels; Vasodilator Agents | 1992 |
Efficacy of nicorandil versus propranolol in mild stable angina pectoris of effort: a long-term, double-blind, randomized study.
Topics: Angina Pectoris; Blood Pressure; Double-Blind Method; Drug Administration Schedule; Exercise; Heart Rate; Humans; Male; Middle Aged; Niacinamide; Nicorandil; Propranolol; Vasodilator Agents | 1992 |
Antianginal and anti-ischemic efficacy of nicorandil compared with nifedipine in patients with angina pectoris and coronary heart disease: a double-blind, randomized, multicenter study.
Topics: Adult; Aged; Angina Pectoris; Blood Pressure; Coronary Disease; Double-Blind Method; Electrocardiography; Exercise; Female; Heart Rate; Humans; Male; Middle Aged; Niacinamide; Nicorandil; Nifedipine; Potassium Channels; Tablets | 1992 |
Antianginal and anti-ischemic efficacy of nicorandil in comparison with isosorbide-5-mononitrate and isosorbide dinitrate: results from two multicenter, double-blind, randomized studies with stable coronary heart disease patients.
Topics: Adult; Aged; Blood Pressure; Coronary Disease; Double-Blind Method; Drug Administration Schedule; Exercise; Female; Heart Rate; Humans; Isosorbide Dinitrate; Male; Middle Aged; Niacinamide; Nicorandil; Potassium Channels; Vasodilator Agents | 1992 |
Prevention of coronary spasm by nicorandil: comparison with nifedipine.
Topics: Administration, Oral; Adult; Coronary Vasospasm; Double-Blind Method; Ergonovine; Humans; Middle Aged; Niacinamide; Nicorandil; Nifedipine; Vasodilator Agents | 1992 |
Selected issues from an overview on nicorandil: tolerance, duration of action, and long-term efficacy.
Topics: Administration, Oral; Administration, Sublingual; Angina Pectoris; Drug Administration Schedule; Drug Tolerance; Exercise; Female; Hemodynamics; Humans; Isosorbide Dinitrate; Male; Niacinamide; Nicorandil; Nitroglycerin | 1992 |
Agreement and reproducibility of the estimates of cardiovascular function by impedance cardiography and M-mode echocardiography in healthy subjects.
Topics: Adult; Antihypertensive Agents; Cardiography, Impedance; Double-Blind Method; Echocardiography; Hemodynamics; Humans; Isosorbide; Male; Niacinamide; Nicorandil; Reproducibility of Results | 1992 |
Clinical pharmacology of nicorandil in patients with congestive heart failure.
Topics: Administration, Oral; Adult; Aged; Analysis of Variance; Cardiovascular System; Double-Blind Method; Female; Half-Life; Heart Failure; Humans; Least-Squares Analysis; Male; Middle Aged; Niacinamide; Nicorandil; Vasodilator Agents | 1992 |
A multicenter comparison of nicorandil and diltiazem on serum lipid, apolipoprotein, and lipoprotein levels in patients with ischemic heart disease.
Topics: Aged; Apolipoproteins; Diltiazem; Female; Humans; Lipids; Lipoproteins; Male; Middle Aged; Myocardial Ischemia; Niacinamide; Nicorandil; Vasodilator Agents | 1992 |
Comparison of the acute hemodynamic and coronary vasodilating effects between nicorandil and glyceryl trinitrate.
Topics: Adult; Blood Pressure; Cardiac Output; Coronary Circulation; Female; Heart Rate; Hemodynamics; Humans; Male; Middle Aged; Niacinamide; Nicorandil; Nitroglycerin; Pulmonary Circulation; Stroke Volume; Vascular Resistance; Vasodilation; Vasodilator Agents | 1991 |
[A new anti-ischemic drug for the treatment of stable effort angina pectoris: nicorandil. Comparison with placebo and isosorbide-5-mononitrate].
Topics: Aged; Angina Pectoris; Double-Blind Method; Exercise Test; Humans; Isosorbide Dinitrate; Male; Middle Aged; Niacinamide; Nicorandil; Placebos; Vasodilator Agents | 1991 |
Usefulness of nicorandil in congestive heart failure.
Topics: Adult; Double-Blind Method; Exercise; Exercise Test; Female; Heart Failure; Hemodynamics; Humans; Male; Middle Aged; Niacinamide; Nicorandil; Randomized Controlled Trials as Topic; Time Factors; Vasodilator Agents | 1990 |
Hemodynamic effects of oral nicorandil in congestive heart failure.
Topics: Administration, Oral; Dose-Response Relationship, Drug; Double-Blind Method; Female; Heart Failure; Hemodynamics; Humans; Male; Middle Aged; Niacinamide; Nicorandil; Randomized Controlled Trials as Topic; Vasodilator Agents | 1990 |
Comparison of nicorandil and atenolol in stable angina pectoris.
Topics: Angina Pectoris; Atenolol; Drug Administration Schedule; Electrocardiography; Exercise Test; Female; Headache; Humans; Male; Middle Aged; Niacinamide; Nicorandil; Randomized Controlled Trials as Topic; Single-Blind Method; Vasodilator Agents | 1990 |
Pharmacology and therapeutic effects of nicorandil.
Topics: Angina Pectoris; Animals; Coronary Vessels; Drug Interactions; Hemodynamics; Humans; Niacinamide; Nicorandil; Vasodilator Agents | 1990 |
Effect of nicorandil on exercise performance in patients with effort angina: a multicenter trial using a treadmill exercise test.
Topics: Adult; Aged; Angina Pectoris; Blood Pressure; Electrocardiography; Female; Heart Rate; Humans; Male; Middle Aged; Niacinamide; Nicorandil; Physical Exertion; Random Allocation; Vasodilator Agents | 1987 |
Effects of nicorandil on left ventricular hemodynamics and volume at rest and during exercise-induced angina pectoris.
Topics: Adult; Angina Pectoris; Clinical Trials as Topic; Double-Blind Method; Hemodynamics; Humans; Male; Middle Aged; Niacinamide; Nicorandil; Physical Exertion; Placebos; Random Allocation; Stroke Volume; Vasodilator Agents | 1989 |
A controlled single-dose study of the efficacy, dose response and duration of action of nicorandil in angina pectoris.
Topics: Administration, Oral; Adult; Aged; Angina Pectoris; Clinical Trials as Topic; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Male; Middle Aged; Niacinamide; Nicorandil; Physical Exertion; Placebos; Random Allocation; Time Factors; Vasodilator Agents | 1989 |
Exercise capacity after single and twice-daily doses of nicorandil in chronic stable angina pectoris.
Topics: Administration, Oral; Angina Pectoris; Chronic Disease; Clinical Trials as Topic; Double-Blind Method; Humans; Male; Middle Aged; Niacinamide; Nicorandil; Physical Exertion; Placebos; Random Allocation; Vasodilator Agents | 1989 |
Comparison of antianginal activity of nicorandil, propranolol and diltiazem with reference to the antianginal mechanism.
Topics: Adult; Angina Pectoris; Clinical Trials as Topic; Diltiazem; Exercise Test; Female; Hemodynamics; Humans; Male; Middle Aged; Niacinamide; Nicorandil; Propranolol; Random Allocation; Vasodilator Agents | 1989 |
Nicorandil, a new vasodilator drug, in patients with essential hypertension.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Diuresis; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Hypertension; Middle Aged; Niacinamide; Nicorandil; Renin-Angiotensin System; Time Factors; Vasodilator Agents | 1989 |
Comparative efficacy of high-dose versus low-dose nicorandil therapy for chronic stable angina pectoris.
Topics: Adult; Aged; Angina Pectoris; Chronic Disease; Female; Humans; Male; Middle Aged; Niacinamide; Nicorandil | 1986 |
Effects of nicorandil on exercise tolerance in patients with stable effort angina: a double-blind study.
Topics: Aged; Angina Pectoris; Clinical Trials as Topic; Double-Blind Method; Exercise Test; Female; Hemodynamics; Humans; Male; Middle Aged; Niacinamide; Nicorandil; Nitroglycerin; Physical Endurance; Physical Exertion; Placebos; Time Factors; Vasodilator Agents | 1986 |
Effect of a new coronary vasodilator, nicorandil, on variant angina pectoris.
Topics: Angina Pectoris, Variant; Clinical Trials as Topic; Electrocardiography; Female; Humans; Male; Middle Aged; Monitoring, Physiologic; Niacinamide; Nicorandil; Time Factors; Vasodilator Agents | 1987 |
Controlled comparison of the pharmacodynamic effects of nicorandil (SG-75) and isosorbide dinitrate in man.
Topics: Adult; Blood Pressure; Clinical Trials as Topic; Electrocardiography; Female; Heart Rate; Hemodynamics; Humans; Isosorbide Dinitrate; Male; Niacinamide; Nicorandil; Systole; Vasodilator Agents | 1984 |
Double-blind comparison of the acute effects of two relevant doses of oral nicorandil on central hemodynamics, left ventricular function, and myocardial contractility.
Topics: Adult; Aged; Anti-Arrhythmia Agents; Blood Pressure; Double-Blind Method; Female; Heart Rate; Hemodynamics; Humans; Male; Middle Aged; Myocardial Contraction; Myocardium; Niacinamide; Nicorandil; Oxygen Consumption; Vascular Resistance; Ventricular Function, Left | 1995 |
Nicorandil safety in the long-term treatment of coronary heart disease.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Blood Pressure; Chronic Disease; Coronary Disease; Drug Interactions; Female; Heart Rate; Humans; Long-Term Care; Male; Middle Aged; Niacinamide; Nicorandil; Prospective Studies | 1995 |
Antiischemic effects of nicorandil during coronary angioplasty in humans.
Topics: Aged; Angioplasty, Balloon, Coronary; Anti-Arrhythmia Agents; Blood Pressure; Coronary Angiography; Coronary Vessels; Electrocardiography; Female; Heart Rate; Humans; Male; Middle Aged; Myocardial Ischemia; Niacinamide; Nicorandil; Oxygen Consumption | 1995 |
Effects of nicorandil on kinetics of oxygen uptake at the onset of exercise in patients with coronary artery disease.
Topics: Adult; Aged; Coronary Disease; Cross-Over Studies; Double-Blind Method; Exercise; Exercise Test; Female; Hemodynamics; Humans; Kinetics; Male; Middle Aged; Niacinamide; Nicorandil; Oxygen; Vasodilator Agents | 1995 |
Hemodynamic effects of bolus nicorandil compared with nitroglycerin.
Topics: Aged; Cardiovascular Diseases; Emergencies; Female; Hemodynamics; Humans; Male; Middle Aged; Niacinamide; Nicorandil; Nitroglycerin; Vasodilator Agents | 1995 |
Acute and subacute effects of nicorandil and isosorbide dinitrate on vessel wall properties of large arteries and hemodynamics in healthy volunteers.
Topics: Administration, Oral; Adolescent; Adult; Biomarkers; Blood Pressure; Brachial Artery; Carotid Arteries; Compliance; Cross-Over Studies; Double-Blind Method; Drug Tolerance; Echocardiography, Doppler; Femoral Artery; Heart Rate; Humans; Isosorbide Dinitrate; Male; Niacinamide; Nicorandil; Regression Analysis; Stroke Volume; Vascular Resistance; Vasodilator Agents | 1995 |
Comparison of hemodynamic effects and plasma cyclic guanosine monophosphate of nicorandil and nitroglycerin in patients with congestive heart failure.
Topics: Adult; Aged; Analysis of Variance; Blood Pressure; Cyclic GMP; Female; Heart Failure; Hemodynamics; Humans; Least-Squares Analysis; Male; Middle Aged; Niacinamide; Nicorandil; Nitroglycerin; Pulmonary Wedge Pressure; Regression Analysis; Vasodilator Agents | 1995 |
Coronary microvascular response to intracoronary administration of nicorandil.
Topics: Adult; Aged; Angina Pectoris; Blood Flow Velocity; Coronary Circulation; Coronary Disease; Coronary Vessels; Dose-Response Relationship, Drug; Electrocardiography; Female; Humans; Male; Microcirculation; Middle Aged; Niacinamide; Nicorandil; Papaverine; Vascular Resistance; Vasodilator Agents | 1995 |
Acute effects of increasing doses of nicorandil on renal function in man.
Topics: Adolescent; Adult; Blood Pressure; Electrolytes; Glomerular Filtration Rate; Heart Rate; Humans; Iodine Radioisotopes; Iodohippuric Acid; Iothalamic Acid; Male; Niacinamide; Nicorandil; Renal Circulation; Single-Blind Method; Vasodilator Agents | 1994 |
Comparison of tolerance to intravenous nitroglycerin during nicorandil and intermittent nitroglycerin patch in healthy volunteers.
Topics: Administration, Cutaneous; Adult; Analysis of Variance; Drug Administration Schedule; Drug Tolerance; Hemodynamics; Humans; Injections, Intravenous; Male; Niacinamide; Nicorandil; Nitroglycerin; Reference Values; Vasodilator Agents | 1994 |
Dose-related haemodynamic effects and pharmacokinetics of oral nicorandil in patients evaluated for chest pain.
Topics: Analysis of Variance; Cardiac Catheterization; Chest Pain; Coronary Disease; Dose-Response Relationship, Drug; Female; Hemodynamics; Humans; Male; Middle Aged; Niacinamide; Nicorandil; Time Factors; Vasodilator Agents | 1994 |
The pharmacokinetics and haemodynamic effects of continuous nicorandil infusion in healthy volunteers.
Topics: Adolescent; Adult; Blood Pressure; Cardiac Output; Electrocardiography; Heart Rate; Hemodynamics; Humans; Infusions, Intravenous; Male; Middle Aged; Niacinamide; Nicorandil; Posture; Single-Blind Method | 1993 |
Absence of hemodynamic tolerance to nicorandil in patients with severe congestive heart failure.
Topics: Adult; Aged; Atrial Natriuretic Factor; Drug Tolerance; Female; Heart Failure; Hemodynamics; Humans; Male; Middle Aged; Niacinamide; Nicorandil; Nitroglycerin; Pulmonary Wedge Pressure; Vasodilator Agents | 1994 |
A double-blind comparison of the long-term efficacy of a potassium channel opener and a calcium antagonist in stable angina pectoris.
Topics: Aged; Angina Pectoris; Coronary Circulation; Coronary Disease; Diltiazem; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Electrocardiography; Exercise Test; Female; Humans; Male; Middle Aged; Myocardial Infarction; Niacinamide; Nicorandil; Potassium Channels; Vasodilator Agents | 1993 |
A double-blind comparison of a beta-blocker and a potassium channel opener in exercise induced angina.
Topics: Aged; Angina Pectoris; Atenolol; Blood Pressure; Coronary Circulation; Coronary Disease; Double-Blind Method; Electrocardiography; Exercise Test; Female; Heart Rate; Humans; Male; Middle Aged; Niacinamide; Nicorandil; Vasodilator Agents | 1993 |
The haemodynamic effects and pharmacokinetics of intravenous nicorandil in healthy volunteers.
Topics: Adolescent; Adult; Blood Pressure; Electrocardiography; Female; Heart Rate; Hemodynamics; Humans; Infusions, Intravenous; Male; Middle Aged; Niacinamide; Nicorandil; Posture; Single-Blind Method; Vasodilator Agents | 1993 |
A double-blind comparison of nicorandil and metoprolol in stable effort angina pectoris.
Topics: Adult; Angina Pectoris; Blood Pressure; Dose-Response Relationship, Drug; Double-Blind Method; Exercise Test; Female; Heart Rate; Humans; Hypertension; Male; Metoprolol; Middle Aged; Niacinamide; Nicorandil; Nitroglycerin; Vasodilator Agents | 1993 |
Coronary dilating effects of intracoronary nicorandil. Comparison with isosorbide dinitrate.
Topics: Angina Pectoris; Atrial Fibrillation; Cardiomyopathy, Hypertrophic; Coronary Circulation; Coronary Vessels; Dose-Response Relationship, Drug; Female; Humans; Isosorbide Dinitrate; Male; Myocardial Infarction; Niacinamide; Nicorandil; Sick Sinus Syndrome; Vasodilator Agents | 1995 |
Effective and safe dose of intracoronary nicorandil in man.
Topics: Aged; Coronary Angiography; Coronary Disease; Coronary Vessels; Dose-Response Relationship, Drug; Female; Hemodynamics; Humans; Injections, Intra-Arterial; Male; Middle Aged; Niacinamide; Nicorandil; Oxygen; Vasodilation; Vasodilator Agents | 1995 |
[Effects of nicorandil on coronary collateral circulation depend on the donor arteries].
Topics: Adult; Aged; Angina Pectoris; Collateral Circulation; Coronary Circulation; Exercise Test; Female; Heart; Hemodynamics; Humans; Male; Middle Aged; Niacinamide; Nicorandil; Perfusion; Physical Endurance; Thallium Radioisotopes; Tomography, Emission-Computed, Single-Photon; Vasodilator Agents | 1996 |
[Clinical use of potassium channel activators in angina pectoris: efficacy and tolerance].
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Exercise Test; Humans; Isosorbide Dinitrate; Myocardial Ischemia; Niacinamide; Nicorandil; Potassium Channels; Vasodilator Agents | 1995 |
Salutary effect of adjunctive intracoronary nicorandil administration on restoration of myocardial blood flow and functional improvement in patients with acute myocardial infarction.
Topics: Angioplasty, Balloon, Coronary; Contrast Media; Coronary Circulation; Coronary Vessels; Echocardiography; Female; Humans; Injections; Ioxaglic Acid; Male; Microcirculation; Middle Aged; Myocardial Contraction; Myocardial Infarction; Niacinamide; Nicorandil; Platelet Aggregation Inhibitors; Potassium Channels; Thrombolytic Therapy | 1997 |
Effects of nicorandil, an antianginal potassium channel opener, on left ventricular systolic and diastolic function in patients with chronic coronary artery disease.
Topics: Adult; Aged; Chronic Disease; Coronary Disease; Diastole; Female; Humans; Male; Middle Aged; Niacinamide; Nicorandil; Nifedipine; Nitroglycerin; Potassium Channels; Systole; Vasodilator Agents; Ventricular Function, Left; Ventricular Pressure | 1997 |
Effects of short-term treatment of nicorandil on exercise-induced myocardial ischemia and abnormal cardiac autonomic activity in microvascular angina.
Topics: Administration, Oral; Aged; Angina Pectoris; Coronary Angiography; Cross-Over Studies; Double-Blind Method; Electrocardiography, Ambulatory; Exercise Test; Female; Heart Conduction System; Heart Rate; Hemodynamics; Humans; Male; Middle Aged; Myocardial Ischemia; Niacinamide; Nicorandil; Reproducibility of Results; Vasodilator Agents | 1997 |
Comparison of the degree of hemodynamic tolerance during intravenous infusion of nitroglycerin versus nicorandil in patients with congestive heart failure.
Topics: Aged; Cross-Over Studies; Double-Blind Method; Female; Heart Failure; Hemodynamics; Humans; Infusions, Intravenous; Male; Middle Aged; Niacinamide; Nicorandil; Nitroglycerin; Treatment Outcome; Vasodilator Agents | 1997 |
Clinical suppression of bradycardia dependent premature ventricular contractions by the potassium channel opener nicorandil.
Topics: Adult; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Drug Administration Schedule; Electrocardiography, Ambulatory; Female; Heart Rate; Humans; Male; Middle Aged; Niacinamide; Nicorandil; Ventricular Premature Complexes | 1998 |
Cardioprotective effect of intravenous nicorandil in patients with successful reperfusion for acute myocardial infarction.
Topics: Acute Disease; Anti-Arrhythmia Agents; Humans; Injections, Intravenous; Myocardial Infarction; Myocardial Reperfusion; Myocardial Reperfusion Injury; Niacinamide; Nicorandil; Potassium Channels | 1998 |
Differential effects of N-acetylcysteine on nitroglycerin- and nicorandil-induced vasodilation in human coronary circulation.
Topics: Acetylcysteine; Coronary Circulation; Coronary Disease; Coronary Vessels; Female; Free Radical Scavengers; Hemodynamics; Humans; Male; Middle Aged; Niacinamide; Nicorandil; Nitroglycerin; Vasodilation; Vasodilator Agents | 1998 |
[Prophylactic effect of nicorandil on perioperative coronary spasm].
Topics: Coronary Artery Bypass; Coronary Vasospasm; Elective Surgical Procedures; Humans; Niacinamide; Nicorandil; Perioperative Care; Retrospective Studies; Vasodilator Agents | 1998 |
434 other study(ies) available for niacinamide and nicorandil
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Synthesis, antinociceptive activity and pharmacokinetic profiles of nicorandil and its isomers.
Topics: Analgesics; Animals; Disease Models, Animal; Female; Half-Life; Isomerism; Mice; Nicorandil; Pain | 2014 |
Circumstantial evidence for increased potassium conductance of membrane of cardiac muscle by 2-nicotinamidoethyl nitrate (SG-75).
Topics: Animals; Atropine; Depression, Chemical; Dogs; Female; In Vitro Techniques; Male; Membrane Potentials; Methacholine Compounds; Myocardial Contraction; Niacinamide; Nicorandil; Nitrates; Papillary Muscles; Perfusion; Potassium; Refractory Period, Electrophysiological; Ventricular Fibrillation; Verapamil | 1979 |
Hemodynamic and neurohumoral responses to intravenous nicorandil in congestive heart failure in humans.
Topics: Aged; Atrial Natriuretic Factor; Blood Pressure; Cardiac Output; Female; Heart Failure; Heart Rate; Hemodynamics; Humans; Male; Middle Aged; Neurotransmitter Agents; Niacinamide; Nicorandil; Norepinephrine; Pulmonary Wedge Pressure; Renin; Vasodilator Agents | 1992 |
Nicorandil attenuates myocardial dysfunction associated with transient ischemia by opening ATP-dependent potassium channels.
Topics: Adenosine Triphosphate; Animals; Blood Glucose; Blood Pressure; Coronary Circulation; Dogs; Female; Glyburide; Heart; Heart Rate; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Niacinamide; Nicorandil; Potassium Channels; Ventricular Function, Left | 1992 |
Evolving Issues in the Treatment of Angina Pectoris. Nicorandil: The 1st Potassium-Channel Activator in Ischemic Heart Disease. Proceedings of an International Workshop. Taormina, Sicily, May 8-12, 1991.
Topics: Animals; Humans; Myocardial Ischemia; Niacinamide; Nicorandil; Potassium Channels | 1992 |
Molecular mechanism of action of nicorandil.
Topics: Animals; Benzopyrans; Cattle; Coronary Vessels; Cromakalim; Cyclic GMP; Dose-Response Relationship, Drug; In Vitro Techniques; Niacinamide; Nicorandil; Nitroglycerin; Nitroprusside; Pyrroles; Vasodilation; Vasodilator Agents | 1992 |
Relaxation of human coronary artery and arteria mammaria by K(+)-channel openers.
Topics: Benzopyrans; Coronary Vessels; Dihydropyridines; Humans; In Vitro Techniques; Mammary Arteries; Niacinamide; Nicorandil; Potassium Channels; Vasodilation; Vasodilator Agents | 1992 |
Differential effects of nitrovasodilators, K(+)-channel openers, and nicorandil on large and small coronary arteries in conscious dogs.
Topics: Animals; Benzopyrans; Coronary Vessels; Cromakalim; Dogs; Dose-Response Relationship, Drug; Injections, Intravenous; Molsidomine; Niacinamide; Nicorandil; Nifedipine; Nitroglycerin; Potassium Channels; Pyrroles; Vasodilation; Vasodilator Agents | 1992 |
Cardioprotective effects of nicorandil.
Topics: Animals; Benzopyrans; Coronary Circulation; Dihydropyridines; Dogs; Female; Heart; In Vitro Techniques; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Neutrophils; Niacinamide; Nicorandil; Nifedipine; Potassium Channels; Rats; Rats, Sprague-Dawley; Reperfusion; Superoxides | 1992 |
Effects of long-term nicorandil application on coronary arteries in conscious dogs.
Topics: Animals; Blood Pressure; Coronary Vessels; Dogs; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Tolerance; Female; Heart Rate; Infusions, Intra-Arterial; Infusions, Intravenous; Male; Niacinamide; Nicorandil; Nitroglycerin; Vasodilation | 1992 |
Pharmacokinetic profile of nicorandil in humans: an overview.
Topics: Administration, Oral; Adult; Age Factors; Cimetidine; Drug Administration Schedule; Drug Interactions; Humans; Injections, Intravenous; Male; Niacinamide; Nicorandil; Rifampin | 1992 |
Nicorandil and cardiovascular performance in patients with coronary artery disease.
Topics: Administration, Sublingual; Coronary Circulation; Coronary Disease; Female; Hemodynamics; Humans; Isosorbide Dinitrate; Male; Middle Aged; Niacinamide; Nicorandil; Vasodilation; Vasodilator Agents; Ventricular Function, Left | 1992 |
Venodilatory effects of nicorandil in healthy volunteers.
Topics: Administration, Oral; Administration, Sublingual; Hand; Humans; Niacinamide; Nicorandil; Nitroglycerin; Vasodilation; Vasodilator Agents; Veins | 1992 |
Pharmacological characterization of nicorandil by 86Rb efflux and isometric vasorelaxation studies in vascular smooth muscle.
Topics: Animals; Aorta; Benzopyrans; Cromakalim; Glyburide; In Vitro Techniques; Niacinamide; Nicorandil; Nitroprusside; Potassium Channels; Pyrroles; Rabbits; Rubidium Radioisotopes; Vasodilation; Vasodilator Agents | 1992 |
Class III antiarrhythmic action by potassium channel blockade: dofetilide attenuates hypoxia induced electromechanical changes.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Glyburide; Guinea Pigs; Muscles; Niacinamide; Nicorandil; Oxygen; Papillary Muscles; Phenethylamines; Potassium Channels; Sulfonamides; Vasodilator Agents | 1992 |
[The bioavailability of nicorandil after oral administration of a single dose of 10 or 20 mg preparations].
Topics: Adult; Biological Availability; Humans; Niacinamide; Nicorandil | 1992 |
Changes in responsiveness of the aorta to vasorelaxant agents in genetically diabetic rats: a study in WBN/Kob rats.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Colforsin; Cromakalim; Diabetes Mellitus, Experimental; Endothelium, Vascular; Isoproterenol; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Pyrroles; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Vasodilator Agents | 1992 |
Anti-free-radical and neutrophil-modulating properties of the nitrovasodilator, nicorandil.
Topics: Animals; Dogs; Dose-Response Relationship, Drug; Free Radical Scavengers; Free Radicals; Glyburide; Hydroxides; Hydroxyl Radical; In Vitro Techniques; Neutrophils; Niacinamide; Nicorandil; Nitroglycerin; Opsonin Proteins; Superoxides; Tetradecanoylphorbol Acetate; Vasodilator Agents | 1992 |
Pharmacological interaction experiments differentiate between glibenclamide-sensitive K+ channels and cyclic GMP as components of vasodilation by nicorandil.
Topics: Animals; Benzopyrans; Cattle; Coronary Vessels; Cromakalim; Cyclic GMP; Drug Interactions; Glyburide; Guanidines; In Vitro Techniques; Methylene Blue; Molsidomine; Muscle Relaxation; Niacinamide; Nicorandil; Nitroprusside; Pinacidil; Potassium Channels; Pyrroles; Sensitivity and Specificity; Vasodilator Agents | 1992 |
Contribution of cyclic GMP formation to KRN2391-induced relaxation in coronary artery of the pig.
Topics: Animals; Coronary Vessels; Cyclic GMP; Dose-Response Relationship, Drug; In Vitro Techniques; Niacinamide; Nicorandil; Nitroglycerin; Pyridines; Swine; Vasodilation; Vasodilator Agents | 1992 |
Vasodilatation of canine cerebral arteries by nicorandil, pinacidil and lemakalim.
Topics: Animals; Basilar Artery; Benzopyrans; Cerebral Arteries; Cromakalim; Dogs; Female; Glyburide; Guanidines; Guanylate Cyclase; In Vitro Techniques; Male; Methylene Blue; Muscle Contraction; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Vasodilation; Vasodilator Agents | 1992 |
Spasmolytic action of nicorandil in canine conductive coronary arteries in vivo is not modified by glibenclamide.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Angiocardiography; Animals; Benzopyrans; Coronary Circulation; Coronary Vasospasm; Coronary Vessels; Cromakalim; Dogs; Female; Glyburide; Male; Niacinamide; Nicorandil; Nitroglycerin; Parasympatholytics; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Vasodilator Agents | 1992 |
Comparison of KRN2391 with nicorandil and nifedipine on canine coronary blood flow: antagonism by glibenclamide.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Coronary Circulation; Dogs; Dose-Response Relationship, Drug; Female; Glyburide; Heart Rate; Male; Niacinamide; Nicorandil; Nifedipine; Potassium Channels; Pyridines; Vascular Resistance | 1992 |
Influences of exposure to cigarette smoke on concentration of nicorandil in plasma of rats.
Topics: Administration, Oral; Animals; Chromatography, High Pressure Liquid; Injections, Intraperitoneal; Injections, Intravenous; Intestinal Absorption; Male; Niacinamide; Nicorandil; Rats; Rats, Inbred Strains; Tobacco Smoke Pollution; Vasodilator Agents | 1992 |
Vasopressin modulates K(+)-channel activities of cultured smooth muscle cells from porcine coronary artery.
Topics: Adenosine Triphosphate; Animals; Cells, Cultured; Coronary Vessels; Electrophysiology; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Potassium Channels; Swine; Vasopressins | 1992 |
Suppression of sympathetic nervous system activity by nicorandil during exercise.
Topics: Adult; Aged; Coronary Disease; Depression, Chemical; Electroencephalography; Epinephrine; Exercise; Female; Heart Rate; Hemodynamics; Humans; Male; Middle Aged; Niacinamide; Nicorandil; Norepinephrine; Sympathetic Nervous System | 1992 |
Cardiovascular effects of the novel potassium channel opener bimakalim in conscious pigs after myocardial infarction: a comparative study with nicorandil.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Dihydropyridines; Hemodynamics; Myocardial Infarction; Niacinamide; Nicorandil; Potassium Channels; Propranolol; Swine; Vasodilation; Ventricular Function, Left | 1992 |
Effects of imidazoline-related compounds on the mechanical response to nicorandil in the rat portal vein.
Topics: Animals; Benzopyrans; Cromakalim; Imidazoles; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Portal Vein; Potassium Channels; Pyrroles; Rats; Rats, Wistar | 1992 |
[Efficacy of nicorandil on myocardial protection during coronary artery bypass grafting--a comparison with diltiazem].
Topics: Cardioplegic Solutions; Coronary Artery Bypass; Diltiazem; Heart; Heart Rate; Humans; Middle Aged; Myocardium; Niacinamide; Nicorandil; Vasodilator Agents | 1992 |
Intermittent anterior divisional block and far advanced right bundle branch block induced by vasospasm during exercise testing.
Topics: Aged; Bundle-Branch Block; Coronary Vasospasm; Electrocardiography; Exercise Test; Heart Block; Humans; Male; Niacinamide; Nicorandil; Nitrates | 1992 |
Comparison of the in vitro effects of K+ channel modulators on detrusor and portal vein strips from guinea pigs.
Topics: Animals; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Guanidines; Guinea Pigs; In Vitro Techniques; Male; Minoxidil; Muscle, Smooth; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Pinacidil; Portal Vein; Potassium Channels; Potassium Chloride; Pyrroles; Vasoconstriction; Vasodilator Agents | 1992 |
Effects of nicorandil on regional cerebral blood flow in patients with chronic cerebral infarction. Preliminary communication.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Carbon Dioxide; Cerebral Infarction; Cerebrovascular Circulation; Female; Humans; Male; Middle Aged; Niacinamide; Nicorandil; Xenon Radioisotopes | 1992 |
[The vasospasmolytic effects of nicorandil, cromakalim and pinacidil on 3,4-diaminopyridine-induced phasic contractions in canine coronary arteries as an experimental vasospasm model].
Topics: 4-Aminopyridine; Amifampridine; Animals; Benzopyrans; Coronary Vasospasm; Cromakalim; Disease Models, Animal; Dogs; Female; Glyburide; Guanidines; In Vitro Techniques; Ion Channel Gating; Male; Methylene Blue; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Vasodilator Agents | 1992 |
Pro-arrhythmic effect of nicorandil in isolated rabbit atria and its suppression by tolbutamide and quinidine.
Topics: Action Potentials; Animals; Female; Heart Atria; In Vitro Techniques; Male; Niacinamide; Nicorandil; Potassium Channels; Quinidine; Rabbits; Tachycardia; Tolbutamide; Vasodilator Agents | 1992 |
Role of intracellular Ca2+ and the calmodulin messenger system in pepsinogen secretion from isolated rabbit gastric mucosa.
Topics: Animals; Calcium; Calmodulin; Carbachol; Colforsin; Dose-Response Relationship, Drug; Gastric Mucosa; Niacinamide; Nicorandil; Organ Culture Techniques; Pepsinogens; Rabbits; Second Messenger Systems; Sincalide; Sulfonamides; Verapamil | 1992 |
Comparison of the development of tolerance to nitroglycerin in aortic preparations isolated from non-diabetic and diabetic rats.
Topics: Acetylcysteine; Animals; Aorta, Thoracic; Blood Glucose; Culture Techniques; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Dose-Response Relationship, Drug; Drug Tolerance; Glycated Hemoglobin; Male; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitroglycerin; Norepinephrine; Rats; Rats, Inbred Strains; Vasodilation; Vasodilator Agents | 1992 |
Alterations in macrophage free radical and tumor necrosis factor production by a potassium channel activator.
Topics: Animals; Cell Survival; Free Radicals; Macrophages; Niacinamide; Nicorandil; Oxygen; Potassium Channels; Transcription, Genetic; Tumor Necrosis Factor-alpha | 1992 |
The resistance of some rat cerebral arteries to the vasorelaxant effect of cromakalim and other K+ channel openers.
Topics: Acetylcholine; Animals; Antihypertensive Agents; Benzopyrans; Cerebellum; Cerebral Arteries; Cromakalim; Guanidines; Guinea Pigs; Niacinamide; Nicorandil; Nitric Oxide; Nitroglycerin; Pinacidil; Potassium Channels; Pyrroles; Rabbits; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vascular Resistance; Vasodilator Agents | 1992 |
[Increase of potassium conductance and spontaneous electric activity in vitro: comparison of nicorandil and cicletanine].
Topics: Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Diuretics; Electrophysiology; Female; Guinea Pigs; Heart; Heart Rate; In Vitro Techniques; Monoamine Oxidase Inhibitors; Niacinamide; Nicorandil; Potassium; Pyridines; Random Allocation; Time Factors; Vasodilator Agents | 1992 |
Pharmacokinetics of nicorandil in patients with normal and impaired renal function.
Topics: Administration, Oral; Adult; Aged; Antihypertensive Agents; Female; Half-Life; Humans; Kidney Diseases; Male; Metabolic Clearance Rate; Middle Aged; Niacinamide; Nicorandil; Vasodilator Agents | 1992 |
2-Nicotinamidoethyl acetate (SG-209) is a potassium channel opener: structure activity relationship among nicorandil derivatives.
Topics: Animals; Cyclic GMP; Glyburide; Male; Methylene Blue; Niacinamide; Nicorandil; Phenylephrine; Potassium Channels; Rabbits; Structure-Activity Relationship; Vasodilation; Vasodilator Agents | 1991 |
Nicorandil reduces the basal level of cytosolic free calcium in single guinea pig ventricular myocytes.
Topics: Animals; Basal Metabolism; Calcium; Calcium-Transporting ATPases; Cyclic GMP; Cytosol; Female; Fura-2; Guinea Pigs; Heart Ventricles; In Vitro Techniques; Male; Membrane Potentials; Niacinamide; Nicorandil; Sarcolemma; Vasodilator Agents | 1991 |
Comparison of nicorandil-induced relaxation, elevations of cyclic guanosine monophosphate and stimulation of guanylate cyclase with organic nitrate esters.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Cyclic GMP; Dogs; Endothelium, Vascular; Enzyme Activation; Esters; Female; Guanylate Cyclase; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitrates; Nitric Oxide; Nitroglycerin; Stimulation, Chemical; Vasodilator Agents | 1991 |
Nicorandil: differential contribution of K+ channel opening and guanylate cyclase stimulation to its vasorelaxant effects on various endothelin-1-contracted arterial preparations. Comparison to aprikalim (RP 52891) and nitroglycerin.
Topics: Animals; Coronary Vessels; Endothelins; Endothelium, Vascular; Glyburide; Guanylate Cyclase; Heart; Hemodynamics; In Vitro Techniques; Male; Methylene Blue; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitroglycerin; Picolines; Potassium Channels; Purinones; Pyrans; Rats; Rats, Inbred Strains; Stimulation, Chemical; Swine; Swine, Miniature; Vasodilator Agents | 1991 |
Effects of N-(2-hydroxyethyl)nicotinamide nitrate (nicorandil; SG-75) and its derivatives on pancreatic exocrine secretion in the dog.
Topics: Amylases; Animals; Bicarbonates; Dogs; Female; Guanidines; Male; Niacinamide; Nicorandil; Nitroglycerin; Pancreatic Juice; Pinacidil; Secretory Rate; Structure-Activity Relationship; Tetraethylammonium Compounds | 1990 |
Nitrate tolerance induced by nicorandil or nitroglycerin is associated with minimal loss of nicorandil vasodilator activity.
Topics: Animals; Arteries; Cattle; Coronary Vessels; Drug Tolerance; In Vitro Techniques; Isosorbide Dinitrate; Molsidomine; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitrates; Nitric Oxide; Nitroglycerin; Vasodilator Agents | 1990 |
Nicorandil improves postischemic contractile function independently of direct myocardial effects.
Topics: Animals; Benzopyrans; Coronary Circulation; Coronary Disease; Cromakalim; Dogs; Heart Function Tests; Heart Rate; In Vitro Techniques; L-Lactate Dehydrogenase; Male; Myocardial Contraction; Myocardium; Niacinamide; Nicorandil; Perfusion; Pyrroles; Rats; Rats, Inbred Strains | 1990 |
Differential effects of the antianginal drug nicorandil on canine arteries and veins.
Topics: Adrenergic alpha-Agonists; Animals; Arteries; Azepines; Dinoprost; Dogs; Drug Interactions; Endothelium, Vascular; Female; In Vitro Techniques; Male; Muscle Contraction; Niacinamide; Nicorandil; Norepinephrine; Phenylephrine; Sympathetic Nervous System; Synaptic Transmission; Vasodilator Agents; Veins | 1990 |
Dual mechanism of the relaxing effect of nicorandil by stimulation of cyclic GMP formation and by hyperpolarization.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Barium; Cattle; Coronary Vessels; Cyclic GMP; Enzyme Activation; Guanylate Cyclase; In Vitro Techniques; Methylene Blue; Muscle Relaxation; Muscle, Smooth, Vascular; Neuromuscular Junction; Niacinamide; Nicorandil; Nitroprusside; Potassium; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Vasodilator Agents | 1991 |
Nicorandil-induced vasorelaxation: functional evidence for K+ channel-dependent and cyclic GMP-dependent components in a single vascular preparation.
Topics: Animals; Calcium; Cyclic GMP; Drug Tolerance; Mesenteric Arteries; Methylene Blue; Muscle Contraction; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitroglycerin; Norepinephrine; Potassium; Potassium Channels; Rabbits; Vasodilator Agents | 1991 |
[Potassium channel activators. Perspectives in the treatment of arterial hypertension].
Topics: Antihypertensive Agents; Benzopyrans; Cromakalim; Guanidines; Humans; Hypertension; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles | 1991 |
Analysis of pulmonary and systemic vascular responses to cromakalim, an activator of K+ATP channels.
Topics: Adenosine Triphosphate; Animals; Antihypertensive Agents; Benzopyrans; Blood Circulation; Cats; Cromakalim; Endothelins; Glyburide; Guanidines; Heart Rate; Hindlimb; Myocardial Contraction; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pulmonary Circulation; Pyrroles; Vascular Resistance; Vasodilator Agents; Ventricular Function, Right | 1991 |
The dualistic mode of action of the vasodilator drug, nicorandil, differentiated by glibenclamide in 86Rb flux studies in rabbit isolated vascular smooth muscle.
Topics: Animals; Aorta; Benzopyrans; Cromakalim; Glyburide; Membranes; Muscle Contraction; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Norepinephrine; Potassium; Potassium Channels; Pyrroles; Rabbits; Rubidium Radioisotopes; Stimulation, Chemical; Vasodilator Agents | 1991 |
Differential antagonism by glibenclamide of the relaxant effects of cromakalim, pinacidil and nicorandil on canine large coronary arteries.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Arteries; Benzopyrans; Coronary Vessels; Cromakalim; Dogs; Dose-Response Relationship, Drug; Female; Glyburide; Guanidines; Male; Methylene Blue; Muscle Contraction; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitroglycerin; Pinacidil; Potassium; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Vasodilator Agents | 1991 |
Influence of footshock stress on pharmacokinetics of nicorandil in rats.
Topics: Absorption; Administration, Oral; Animals; Electroshock; Injections, Intravenous; Injections, Subcutaneous; Male; Niacinamide; Nicorandil; Rats; Rats, Inbred Strains; Stress, Physiological; Tissue Distribution; Vasodilator Agents | 1991 |
Coronary effects of nicorandil in comparison with nitroglycerin in chronic conscious dogs.
Topics: Animals; Blood Pressure; Coronary Vessels; Dogs; Female; Heart Rate; Male; Niacinamide; Nicorandil; Nitroglycerin; Vasodilator Agents | 1991 |
K+ channel blocking and anti-muscarinic effects of a novel piperazine derivative, INO 2628, on the isolated dog atrium.
Topics: Adenosine; Animals; Atrial Function; Depression, Chemical; Dogs; Dose-Response Relationship, Drug; Guanidines; Heart Atria; Myocardial Contraction; Niacinamide; Nicardipine; Nicorandil; Pinacidil; Piperazines; Potassium Channels; Time Factors | 1991 |
Species differences in percutaneous absorption of nicorandil.
Topics: Adult; Animals; Dogs; Female; Galvanic Skin Response; Guinea Pigs; Humans; In Vitro Techniques; Lipids; Mice; Middle Aged; Niacinamide; Nicorandil; Rats; Skin; Skin Absorption; Solubility; Species Specificity; Swine; Vasodilator Agents | 1991 |
Analysis of cromakalim-, pinacidil-, and nicorandil-induced relaxation of the 5-hydroxytryptamine precontracted rat isolated basilar artery.
Topics: Animals; Basilar Artery; Benzopyrans; Cromakalim; Drug Interactions; Glyburide; Guanidines; Male; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists; Vasoconstriction; Vasodilation; Vasodilator Agents | 1991 |
Potassium channel opening properties of a novel compound, NIP-121, cromakalim and nicorandil in rat aorta and portal vein.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Benzopyrans; Cromakalim; Glyburide; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Oxadiazoles; Phentolamine; Piperidines; Portal Vein; Potassium Channels; Potassium Chloride; Pyrroles; Rats; Rats, Inbred Strains; Rubidium Radioisotopes | 1991 |
[The effects of nicorandil on the cardiovascular system under isoflurane anesthesia].
Topics: Anesthesia, Inhalation; Animals; Dogs; Hemodynamics; Isoflurane; Niacinamide; Nicorandil; Vasodilator Agents | 1991 |
Nicorandil (2-nicotinamidoethyl nitrate) inhibits both vaso-dilating and -constricting effects of endothelin in a vascularly isolated hind-limb preparation in rats.
Topics: Analysis of Variance; Animals; Antihypertensive Agents; Blood Pressure; Calcium; Dose-Response Relationship, Drug; Endothelins; Male; Muscle, Smooth; Niacinamide; Nicorandil; Perfusion; Rats; Rats, Inbred Strains; Regional Blood Flow; Vascular Resistance; Vasodilator Agents | 1991 |
Effect of three novel K+ channel openers, cromakalim, pinacidil and nicorandil on allergic reaction and experimental asthma.
Topics: Airway Resistance; Animals; Asthma; Benzopyrans; Bronchodilator Agents; Cromakalim; Guanidines; Guinea Pigs; In Vitro Techniques; Mice; Mice, Inbred Strains; Niacinamide; Nicorandil; Passive Cutaneous Anaphylaxis; Pinacidil; Potassium Channels; Pyrroles; Rats; Trachea; Vasculitis | 1991 |
Accelerated myocardial metabolic and functional recovery with terminal nicorandil-Mg cardioplegia in heart transplantation.
Topics: Animals; Coronary Circulation; Dogs; Heart Arrest, Induced; Heart Transplantation; Magnesium; Myocardial Reperfusion Injury; Myocardium; Niacinamide; Nicorandil; Oxygen Consumption | 1991 |
Nicorandil suppresses early afterdepolarisation and ventricular arrhythmias induced by caesium chloride in rabbits in vivo.
Topics: Action Potentials; Animals; Blood Pressure; Cesium; Chlorides; Electrocardiography; Niacinamide; Nicorandil; Rabbits; Tachycardia; Vasodilator Agents | 1991 |
Action of nicorandil on ATP-sensitive K+ channel in guinea-pig ventricular myocytes.
Topics: Adenosine Triphosphate; Animals; Glyburide; Guinea Pigs; Heart Ventricles; In Vitro Techniques; Kinetics; Myocardium; Niacinamide; Nicorandil; Potassium Channels; Vasodilator Agents | 1991 |
Essential role of nucleotide diphosphates in nicorandil-mediated activation of cardiac ATP-sensitive K+ channel. A comparison with pinacidil and lemakalim.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Guanidines; Myocardium; Niacinamide; Nicorandil; Phosphorylation; Pinacidil; Potassium Channels; Pyrroles; Vasodilator Agents | 1991 |
[Protective effects of nicorandil on myocardial mitochondria function during ischemia and reperfusion].
Topics: Animals; Male; Mitochondria, Heart; Myocardial Reperfusion Injury; Niacinamide; Nicorandil; Oxidative Phosphorylation; Rabbits; Vasodilator Agents | 1991 |
A new strategy for the reduction of acute myocardial infarction in variant angina.
Topics: Adult; Aged; Aged, 80 and over; Angina Pectoris, Variant; Angioplasty, Balloon, Coronary; Calcium Channel Blockers; Coronary Angiography; Drug Therapy, Combination; Evaluation Studies as Topic; Female; Humans; Male; Middle Aged; Myocardial Infarction; Niacinamide; Nicorandil; Nitroglycerin; Regression Analysis; Retrospective Studies; Vasodilator Agents | 1991 |
Effects of glibenclamide and nicorandil on cardiac function during ischemia and reperfusion in isolated perfused rat hearts.
Topics: Adenosine Triphosphate; Animals; Coronary Disease; Glyburide; Heart; Kinetics; Male; Myocardial Contraction; Myocardial Reperfusion; Niacinamide; Nicorandil; Potassium; Potassium Channels; Rats; Rats, Inbred Strains; Ventricular Function, Left | 1991 |
[Preventive effect of post-ischemic reperfusion injury by terminal Nicorandil-Mg cardioplegia].
Topics: Heart Arrest, Induced; Heart Valve Diseases; Humans; Myocardial Reperfusion Injury; Myocardium; Niacinamide; Nicorandil; Potassium; Potassium Compounds; Stroke Volume | 1991 |
K+ channel opening mediates the vasorelaxant effects of nicorandil in the intact vascular system.
Topics: Animals; Benzopyrans; Cromakalim; Dogs; Dose-Response Relationship, Drug; Female; Male; Membrane Potentials; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Potassium Channels; Pyrroles; Rats; Rats, Inbred SHR; Vasoconstriction; Vasodilation; Vasodilator Agents | 1991 |
Effects of pinacidil, cromakalim, and nicorandil on potassium currents of rat basilar artery smooth muscle.
Topics: Animals; Antihypertensive Agents; Basilar Artery; Benzopyrans; Calcium; Cerebrovascular Circulation; Cromakalim; Electrophysiology; Guanidines; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains | 1991 |
Cardioprotective effects of KRN2391 and nicorandil on ischemic dysfunction in perfused rat heart.
Topics: Animals; Coronary Disease; Cytosol; Glyburide; Heart Rate; In Vitro Techniques; Male; Myocardium; Niacinamide; Nicorandil; Perfusion; Pyridines; Rats; Rats, Inbred Strains; Vasodilator Agents | 1991 |
The group at C2 of N-ethylnicotinamide determines the vasodilator potencies and mechanisms of action of nicorandil and its congeners in canine coronary arteries.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Coronary Vessels; Dogs; Female; Male; Niacinamide; Nicorandil; Potassium Chloride; Prostaglandin Endoperoxides, Synthetic; Vasodilation; Vasodilator Agents | 1991 |
Intracerebroventricular injections of endothelin increase arterial pressure in conscious rats.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Brain; Endothelins; Guanidines; Injections, Intraventricular; Male; Niacinamide; Nicardipine; Nicorandil; Pinacidil; Quinazolines; Rats; Rats, Inbred Strains; Vasodilator Agents | 1990 |
[Drug therapy of unstable angina].
Topics: Adrenergic beta-Antagonists; Angina, Unstable; Aspirin; Calcium Channel Blockers; Drug Therapy, Combination; Heparin; Humans; Niacinamide; Nicorandil; Nitroglycerin | 1990 |
In vitro cardiac models of dog Purkinje fibre triggered and spontaneous electrical activity: effects of nicorandil.
Topics: Action Potentials; Animals; Dogs; Electrophysiology; Female; Heart; Heart Conduction System; Hydrogen-Ion Concentration; In Vitro Techniques; Male; Membrane Potentials; Niacinamide; Nicorandil; Purkinje Fibers | 1990 |
Determination of nicorandil in plasma using high-performance liquid chromatography with photoconductivity and ultraviolet detection. Application to pre-clinical pharmacokinetics in beagle dogs.
Topics: Animals; Chromatography, High Pressure Liquid; Dogs; Niacinamide; Nicorandil; Photometry; Ultraviolet Rays; Vasodilator Agents | 1990 |
[Preventive effect of post-ischemic reperfusion injury by terminal Nicorandil-Mg cardioplegia].
Topics: Animals; Dogs; Heart Arrest, Induced; Magnesium; Myocardial Reperfusion Injury; Niacinamide; Nicorandil; Vasodilator Agents | 1990 |
Angiographic response to a vasodilating drug, nicorandil, in patients with coronary artery disease.
Topics: Administration, Sublingual; Adult; Aged; Coronary Angiography; Coronary Disease; Coronary Vessels; Female; Hemodynamics; Humans; Male; Middle Aged; Niacinamide; Nicorandil; Time Factors; Vasodilation; Vasodilator Agents | 1990 |
Effects of cromakalim, pinacidil and nicorandil on cardiac refractoriness and arterial pressure in open-chest dogs.
Topics: Animals; Atrioventricular Node; Benzopyrans; Blood Pressure; Cromakalim; Dogs; Dose-Response Relationship, Drug; Electrocardiography; Female; Guanidines; Heart Conduction System; Heart Rate; Male; Neural Conduction; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Refractory Period, Electrophysiological | 1990 |
Rapid and simple determination of nicorandil in rat plasma using a solid-phase extraction column.
Topics: Animals; Chromatography, High Pressure Liquid; Male; Niacinamide; Nicorandil; Rats; Rats, Inbred Strains; Spectrophotometry, Ultraviolet; Vasodilator Agents | 1990 |
Specific but differential antagonism by glibenclamide of the vasodepressor effects of cromakalim and nicorandil in spinally-anaesthetized dogs.
Topics: Anesthesia, Spinal; Animals; Benzopyrans; Blood Pressure; Calcium Channel Blockers; Cromakalim; Diltiazem; Dogs; Dose-Response Relationship, Drug; Female; Glyburide; Heart Rate; Hemodynamics; Male; Myocardial Contraction; Niacinamide; Nicorandil; Nitroglycerin; Norepinephrine; Potassium Channels; Pyrroles | 1990 |
Nicorandil opens a calcium-dependent potassium channel in smooth muscle cells of the rat portal vein.
Topics: 4-Aminopyridine; Animals; Cell Membrane; Electric Conductivity; Male; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Portal Vein; Potassium Channels; Rats; Rats, Inbred Strains; Tetraethylammonium; Tetraethylammonium Compounds; Vasodilator Agents | 1990 |
[Clinical electrophysiological effects of nicorandil on the conduction system in humans].
Topics: Coronary Disease; Electrophysiology; Female; Heart Conduction System; Heart Rate; Humans; Male; Middle Aged; Niacinamide; Nicorandil; Vasodilator Agents | 1990 |
Determination of effective and safe dose for intracoronary administration of nicorandil in dogs.
Topics: Animals; Arrhythmias, Cardiac; Coronary Circulation; Coronary Vessels; Dogs; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Evaluation, Preclinical; Electrocardiography; Female; Infusions, Intra-Arterial; Male; Myocardial Contraction; Niacinamide; Nicorandil; Vasodilator Agents | 1990 |
Effects of standard cigarette and nicotine-less cigarette smoke inhalings on nicorandil plasma levels in rats.
Topics: Administration, Oral; Animals; Chromatography, High Pressure Liquid; Male; Niacinamide; Nicorandil; Nicotiana; Nicotine; Plants, Toxic; Rats; Rats, Inbred Strains; Smoking; Time Factors | 1990 |
Cytoplasmic calcium and the relaxation of canine coronary arterial smooth muscle produced by cromakalim, pinacidil and nicorandil.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Calcium; Coronary Vessels; Cromakalim; Cytoplasm; Dogs; Female; Fluorescence; Glyburide; Guanidines; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Pinacidil; Potassium Chloride; Pyrroles; Quaternary Ammonium Compounds | 1990 |
Effect of low grade exercise training and a vasodilator on cardiac function in patients with recent myocardial infarction.
Topics: Cardiac Output; Exercise Therapy; Female; Hemodynamics; Humans; Male; Middle Aged; Myocardial Infarction; Niacinamide; Nicorandil; Pulmonary Wedge Pressure; Vasodilator Agents; Ventricular Function, Left | 1990 |
Specific antagonism by glibenclamide of negative inotropic effects of potassium channel openers in canine atrial muscle.
Topics: Animals; Benzopyrans; Carbachol; Cromakalim; Dogs; Female; Glyburide; Guanidines; Heart Atria; Male; Myocardial Contraction; Niacinamide; Nicorandil; Nifedipine; Pinacidil; Potassium Channels; Pyrroles; Vasodilator Agents | 1990 |
Nicorandil is a potent dilator of endothelin-induced vascular contraction.
Topics: Animals; Aorta; Calcium; Dose-Response Relationship, Drug; Endothelins; Muscle Contraction; Muscle, Smooth, Vascular; Niacinamide; Nicardipine; Nicorandil; Rats; Rats, Inbred Strains; Vasoconstriction; Vasodilator Agents; Verapamil | 1990 |
Left ventricular effects of nicorandil in comparison with nitroglycerin in chronic conscious dogs.
Topics: Animals; Dogs; Heart Ventricles; Hemodynamics; Injections, Intravenous; Niacinamide; Nicorandil; Nitroglycerin; Vasodilator Agents | 1990 |
Nicorandil increases coronary blood flow predominantly by K-channel opening mechanism.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Coronary Circulation; Cromakalim; Dogs; Dose-Response Relationship, Drug; Female; Glyburide; In Vitro Techniques; Male; Myocardial Contraction; Niacinamide; Nicorandil; Nitroglycerin; Potassium Channels; Pyrroles; Vasodilator Agents | 1990 |
[Effect of nicorandil on coronary circulation in ischemic region].
Topics: Animals; Blood Viscosity; Coronary Circulation; Coronary Disease; Dogs; Female; Hemodynamics; Infusions, Intra-Arterial; Male; Niacinamide; Nicorandil; Vascular Resistance; Vasodilator Agents | 1990 |
Selective modulation of the ATP-sensitive K+ channel by nicorandil in guinea-pig cardiac cell membrane.
Topics: Adenosine Triphosphate; Animals; Cell Membrane; Guinea Pigs; Heart; In Vitro Techniques; Kinetics; Myocardium; Niacinamide; Nicorandil; Potassium Channels; Vasodilator Agents | 1990 |
[Protective effects of nicorandil on lipid peroxidation in ischemic and reperfused myocardium of rabbits].
Topics: Animals; Creatine Kinase; Lipid Peroxidation; Male; Malondialdehyde; Myocardial Reperfusion Injury; Myocardium; Niacinamide; Nicorandil; Rabbits; Vascular Resistance; Vasodilator Agents | 1990 |
Effects of pinacidil, RP 49356 and nicorandil on ATP-sensitive potassium channels in insulin-secreting cells.
Topics: Adenoma, Islet Cell; Adenosine Triphosphate; Diazoxide; Glucose; Guanidines; Humans; Insulin; Insulinoma; Islets of Langerhans; Membrane Potentials; Niacinamide; Nicorandil; Pancreatic Neoplasms; Picolines; Pinacidil; Potassium Channels; Pyrans; Rubidium Radioisotopes; Tumor Cells, Cultured | 1990 |
The different mechanisms of action of nicorandil and adenosine triphosphate on potassium channels of circular smooth muscle of the guinea-pig small intestine.
Topics: Adenosine Triphosphate; Anesthetics, Local; Animals; Apamin; Cocaine; Electric Stimulation; Female; Guinea Pigs; In Vitro Techniques; Intestine, Small; Ion Channels; Lidocaine; Male; Membrane Potentials; Muscle, Smooth; Niacinamide; Nicorandil; Procaine; Vasodilator Agents | 1985 |
The relaxant action of nicorandil in guinea-pig isolated trachealis.
Topics: Aminophylline; Animals; Dose-Response Relationship, Drug; Female; Guinea Pigs; In Vitro Techniques; Ion Channels; Isoproterenol; Male; Membrane Potentials; Methylene Blue; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Niacinamide; Nicorandil; Nitrates; Nitroprusside; Potassium; Propranolol; Receptors, Adrenergic, beta; Rubidium; Tetraethylammonium Compounds; Trachea; Vasodilator Agents | 1986 |
Endothelial-dependent relaxant actions of carbachol and substance P in arterial smooth muscle.
Topics: Animals; Calcimycin; Carbachol; Endothelium; Female; Guinea Pigs; In Vitro Techniques; Indomethacin; Male; Membrane Potentials; Mesenteric Arteries; Monoamine Oxidase Inhibitors; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Potassium; Rabbits; Substance P | 1986 |
Effect of apamin on responses to BRL 34915, nicorandil and other relaxants in the guinea-pig taenia caeci.
Topics: Adenosine Triphosphate; Animals; Antihypertensive Agents; Apamin; Bee Venoms; Benzopyrans; Cecum; Cromakalim; Female; Guinea Pigs; In Vitro Techniques; Ion Channels; Isoproterenol; Male; Muscle Relaxants, Central; Muscle Tonus; Muscle, Smooth; Niacinamide; Nicorandil; Norepinephrine; Pyrroles | 1986 |
The effects of BRL 34915 and nicorandil on electrical and mechanical activity and on 86Rb efflux in rat blood vessels.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Benzopyrans; Cromakalim; In Vitro Techniques; Ion Channels; Male; Membrane Potentials; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Norepinephrine; Portal Vein; Pyrroles; Radioisotopes; Rats; Rats, Inbred Strains; Rubidium; Time Factors | 1986 |
Thyrotropin-releasing hormone stimulation of thyrotropin secretion is suppressed by calcium ion antagonists that block transmembrane influx and intracellular mobilization of calcium ion in human subjects.
Topics: Adult; Calcium; Calcium Channel Blockers; Humans; Ion Channels; Male; Niacinamide; Nicorandil; Nifedipine; Thyrotropin; Thyrotropin-Releasing Hormone | 1986 |
Phasic contractions of canine and human coronary arteries induced by potassium channel blockers.
Topics: 4-Aminopyridine; Adult; Aged; Amifampridine; Aminopyridines; Angina Pectoris, Variant; Animals; Arteries; Coronary Vasospasm; Coronary Vessels; Dogs; Female; Humans; Ion Channels; Macaca mulatta; Male; Middle Aged; Models, Biological; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nifedipine; Swine; Tetraethylammonium Compounds; Vasoconstriction | 1986 |
The potassium current activated by 2-nicotinamidoethyl nitrate (nicorandil) in single ventricular cells of guinea pigs.
Topics: Action Potentials; Animals; Calcium; Guinea Pigs; Heart Ventricles; In Vitro Techniques; Ion Channels; Myocardium; Niacinamide; Nicorandil; Potassium | 1986 |
Effects of nicorandil on electromechanical activity of frog atrial muscle.
Topics: Animals; Calcium; Heart; Heart Atria; Heart Rate; In Vitro Techniques; Ion Channels; Myocardial Contraction; Myocardium; Niacinamide; Nicorandil; Potassium; Rana catesbeiana; Vasodilator Agents | 1987 |
Modification by nicorandil and carbachol of the inward calcium current in single cells of the guinea-pig heart.
Topics: Animals; Atrial Function; Calcium; Carbachol; Electric Conductivity; Guinea Pigs; Heart; In Vitro Techniques; Ion Channels; Isoproterenol; Niacinamide; Nicorandil; Vasodilator Agents | 1986 |
Brachial artery cross-sectional area and distensibility before and after arteriolar vasodilatation in men with sustained essential hypertension.
Topics: Adult; Aged; Blood Pressure; Brachial Artery; Female; Hemodynamics; Humans; Hypertension; Male; Middle Aged; Niacinamide; Nicorandil; Nitrendipine; Pyridazines; Vasodilation | 1987 |
Specificity of action of the novel antihypertensive agent, BRL 34915, as a potassium channel activator. Comparison with nicorandil.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Antihypertensive Agents; Apamin; Benzopyrans; Binding Sites; Cromakalim; Cyclic AMP; Cyclic GMP; Inositol Phosphates; Ion Channels; Male; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitrendipine; Potassium; Pyrroles; Rats; Rats, Inbred Strains; Rubidium; Tetraethylammonium Compounds | 1987 |
Comparison of the inhibitory effects of nicorandil, nitroglycerin and isosorbide dinitrate on vascular smooth muscle of rabbit aorta.
Topics: Animals; Aorta; Calcium; Cyclic GMP; In Vitro Techniques; Ion Channels; Isosorbide Dinitrate; Male; Muscle Contraction; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitroglycerin; Norepinephrine; Rabbits | 1987 |
Comparative effects of nicorandil, a nicotinamide nitrate derivative, and nifedipine on myocardial reperfusion injury in dogs.
Topics: Animals; Blood Pressure; Coronary Circulation; Dogs; Female; Male; Myocardial Contraction; Myocardial Infarction; Niacinamide; Nicorandil; Nifedipine | 1987 |
New antianginal therapy. First International Symposium on Nicorandil, a new antianginal agent. Honolulu, Hawaii, U.S.A, January 24-26, 1986.
Topics: Animals; Coronary Vessels; Niacinamide; Nicorandil; Vasodilator Agents | 1987 |
Effects of nicorandil on the conductive coronary artery of the dog.
Topics: Animals; Coronary Vessels; Dogs; Female; In Vitro Techniques; Lanthanum; Male; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nifedipine; Nitroglycerin; Perfusion; Potassium; Vasoconstriction; Vasodilator Agents | 1987 |
Beneficial effects of nicorandil on cardiovascular hemodynamics and left ventricular function.
Topics: Angina Pectoris; Cardiac Catheterization; Cardiac Pacing, Artificial; Coronary Disease; Female; Heart Ventricles; Hemodynamics; Humans; Male; Middle Aged; Niacinamide; Nicorandil; Vasodilator Agents | 1987 |
Effects of nicorandil on coronary hemodynamics in ischemic heart disease: comparison with nitroglycerin, nifedipine, and propranolol.
Topics: Adult; Aged; Cardiac Pacing, Artificial; Coronary Circulation; Coronary Disease; Hemodynamics; Humans; Lactates; Lactic Acid; Middle Aged; Myocardium; Niacinamide; Nicorandil; Nifedipine; Nitroglycerin; Norepinephrine; Oxygen Consumption; Propranolol; Vasodilator Agents | 1987 |
Effects of a new vasodilator, nicorandil, on exercise-induced impairment of left ventricular function in patients with old myocardial infarction.
Topics: Adult; Coronary Circulation; Exercise Test; Heart; Heart Ventricles; Hemodynamics; Humans; Male; Middle Aged; Myocardial Infarction; Niacinamide; Nicorandil; Vasodilator Agents | 1987 |
Effects of nicorandil on coronary circulation in patients with ischemic heart disease: comparison with nitroglycerin.
Topics: Coronary Circulation; Coronary Disease; Coronary Vasospasm; Female; Hemodynamics; Humans; Male; Middle Aged; Niacinamide; Nicorandil; Nitroglycerin; Vasodilation; Vasodilator Agents | 1987 |
Nitrate tolerance: comparison of nicorandil, isosorbide dinitrate, and nitroglycerin in anesthetized dogs.
Topics: Anesthesia; Animals; Coronary Circulation; Dogs; Drug Tolerance; Female; Infusions, Intravenous; Injections, Intra-Arterial; Isosorbide Dinitrate; Male; Niacinamide; Nicorandil; Nitroglycerin; Vasodilator Agents | 1987 |
Cyclic GMP in nicorandil-induced vasodilatation and tolerance development.
Topics: Acetylcysteine; Animals; Cattle; Coronary Vessels; Cyclic GMP; Drug Tolerance; In Vitro Techniques; Isosorbide Dinitrate; Niacinamide; Nicorandil; Nitroglycerin; Vasodilation; Vasodilator Agents | 1987 |
Effect of nicorandil on the cytosolic free calcium concentration and microsomal (Ca2+ + Mg2+)-ATPase activity of vascular smooth muscle cells.
Topics: Angiotensin II; Animals; Ca(2+) Mg(2+)-ATPase; Calcium; Calcium-Transporting ATPases; Cytosol; Dinoprost; Female; In Vitro Techniques; Microsomes; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Prostaglandins F; Rats; Rats, Inbred Strains; Swine; Vasodilator Agents | 1987 |
The mechanism of inhibitory effects of nicorandil, a new antianginal agent, on contractile responses to alpha 1- and alpha 2-adrenoceptor agonists in isolated vascular smooth muscles.
Topics: Adrenergic alpha-Agonists; Animals; Calcium; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Rabbits; Vasodilator Agents | 1987 |
Effects of nicorandil on receptor-mediated Ca2+ release and Ca2+ entry in vascular smooth muscle.
Topics: Animals; Calcium; Egtazic Acid; Female; Gallopamil; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Norepinephrine; Rabbits; Receptors, Cell Surface; Vasoconstriction; Vasodilator Agents | 1987 |
The effects of nicorandil on phasic contractions of isolated canine coronary artery.
Topics: 4-Aminopyridine; Amifampridine; Aminopyridines; Animals; Calmodulin; Coronary Vessels; Dogs; Ergonovine; In Vitro Techniques; Membrane Potentials; Muscle Contraction; Niacinamide; Nicorandil; Nifedipine; Nitroglycerin; Vasodilator Agents | 1987 |
Some effects of nicorandil on the smooth muscles of the rat and guinea pig.
Topics: Animals; Female; Guinea Pigs; In Vitro Techniques; Ion Channels; Male; Membrane Potentials; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Norepinephrine; Potassium; Rats; Rats, Inbred Strains; Rubidium Radioisotopes; Vasoconstriction; Vasodilator Agents | 1987 |
Effect of nicorandil on the excitation-contraction coupling in smooth muscle cells of the rabbit ear artery.
Topics: Action Potentials; Animals; Arteries; Ear, External; Electric Stimulation; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Potassium; Rabbits; Vasodilator Agents | 1987 |
Comparative effects of nicorandil, nitroglycerin, nicotinic acid, and SG-86 on the metabolic status and functional recovery of the ischemic-reperfused myocardium.
Topics: Animals; Coronary Circulation; Coronary Disease; Dogs; Fatty Acids, Nonesterified; Female; Glucose; Heart; Hemodynamics; Male; Myocardial Contraction; Myocardium; Niacin; Niacinamide; Nicorandil; Nitroglycerin; Perfusion; Vasodilator Agents | 1987 |
Effects of nicorandil and other antianginal drugs on myocardial pH in the ischemic dog heart.
Topics: Acidosis; Animals; Coronary Disease; Diltiazem; Dogs; Hydrogen-Ion Concentration; In Vitro Techniques; Myocardium; Niacinamide; Nicorandil; Nitroglycerin; Propranolol; Sotalol; Vasodilator Agents | 1987 |
Examination of the direct effects of nicorandil, verapamil, propranolol, and nitroglycerin on the hypoxic canine myocardium.
Topics: Animals; Coronary Disease; Dogs; Female; Hemodynamics; In Vitro Techniques; Male; Myocardium; Niacinamide; Nicorandil; Nitroglycerin; Perfusion; Propranolol; Vasodilator Agents; Verapamil | 1987 |
Differential antagonism by Bay K 8644 of vasodilator effects of nifedipine, diltiazem, nicorandil and nitroglycerin in dog femoral circulation.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Diltiazem; Dogs; Dose-Response Relationship, Drug; Female; Femoral Artery; Femur; Male; Niacinamide; Nicorandil; Nifedipine; Nitroglycerin; Regional Blood Flow; Vasodilator Agents | 1988 |
Studies on the mechanism of the vasodilator action of nicorandil.
Topics: Acetylcholine; Animals; Aorta; Arteriosclerosis; Endothelium, Vascular; Guanylate Cyclase; Ion Channels; Male; Methylene Blue; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Norepinephrine; Potassium; Rabbits; Vasodilation | 1988 |
Cromakalim, a potassium channel activator: a comparison of its cardiovascular haemodynamic profile and tissue specificity with those of pinacidil and nicorandil.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Cats; Coronary Circulation; Cromakalim; Female; Guanidines; Hemodynamics; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Organ Specificity; Papillary Muscles; Pinacidil; Portal Vein; Potassium Channels; Pyrroles; Rabbits | 1988 |
Reduction of size of myocardial infarction with nicorandil, a new antianginal drug, after coronary artery occlusion in dogs.
Topics: Animals; Coronary Disease; Dogs; Female; Hemodynamics; Male; Myocardial Infarction; Niacinamide; Nicorandil; Vasodilator Agents | 1988 |
Acceleration of recovery of mitochondrial function after coronary reperfusion by various coronary dilating drugs in canine hearts.
Topics: Animals; Blood Pressure; Coronary Circulation; Dilazep; Diltiazem; Dogs; Female; Heart Rate; Hemodynamics; In Vitro Techniques; Male; Mitochondria, Heart; Monoamine Oxidase Inhibitors; Niacinamide; Nicorandil; Reperfusion Injury; Vasodilator Agents | 1989 |
Modulation of the effects of sotalol on Purkinje strand electromechanical characteristics.
Topics: Animals; Dogs; Electrophysiology; Heart; Heart Conduction System; In Vitro Techniques; Ion Channels; Lidocaine; Membrane Potentials; Myocardium; Niacinamide; Nicorandil; Purkinje Fibers; Sotalol; Tetraethylammonium Compounds; Veratrine | 1989 |
Effects of nicorandil and nipradilol on ischemic myocardium in perfused rat heart.
Topics: Adenosine Triphosphate; Animals; Blood Pressure; Coronary Circulation; Coronary Disease; Heart; In Vitro Techniques; Lactates; Male; Niacinamide; Nicorandil; Phosphocreatine; Propanolamines; Rats; Rats, Inbred Strains | 1989 |
A symposium: A new treatment for angina pectoris and heart failure. October 17, 1987, San Francisco. Proceedings.
Topics: Angina Pectoris; Animals; Heart Failure; Humans; Niacinamide; Nicorandil; Vasodilator Agents | 1989 |
Pharmacokinetics of nicorandil.
Topics: Administration, Oral; Adult; Biological Availability; Humans; Injections, Intravenous; Male; Niacinamide; Nicorandil; Protein Binding; Vasodilator Agents | 1989 |
Acute hemodynamic effects of single-dose nicorandil in coronary artery disease.
Topics: Administration, Oral; Administration, Sublingual; Adult; Coronary Disease; Female; Hemodynamics; Humans; Male; Middle Aged; Niacinamide; Nicorandil; Vasodilator Agents | 1989 |
Effects of nicorandil on arterial and venous vessels of the forearm in systemic hypertension.
Topics: Adult; Arteries; Blood Pressure; Female; Forearm; Humans; Hypertension; Male; Middle Aged; Niacinamide; Nicorandil; Regional Blood Flow; Vasodilator Agents; Veins | 1989 |
Hemodynamic action of nicorandil in chronic congestive heart failure.
Topics: Adult; Aged; Blood Pressure; Cardiac Output; Chronic Disease; Female; Heart Failure; Heart Rate; Hemodynamics; Humans; Male; Middle Aged; Niacinamide; Nicorandil; Pulmonary Wedge Pressure; Vascular Resistance; Vasodilator Agents | 1989 |
Effects of intravenous administration of nicorandil on cardiovascular hemodynamics and left ventricular function.
Topics: Aged; Coronary Disease; Female; Hemodynamics; Humans; Injections, Intravenous; Male; Middle Aged; Myocardial Contraction; Niacinamide; Nicorandil; Stroke Volume; Vasodilator Agents | 1989 |
Effect of nicorandil on coronary spasm.
Topics: Adult; Coronary Vasospasm; Ergonovine; Female; Humans; Male; Middle Aged; Niacinamide; Nicorandil; Vasodilator Agents | 1989 |
Coronary vasodilatory action after nicorandil: a quantitative angiographic study.
Topics: Administration, Sublingual; Adult; Aged; Angiography; Coronary Angiography; Coronary Disease; Coronary Vessels; Female; Humans; Male; Middle Aged; Niacinamide; Nicorandil; Vasodilation; Vasodilator Agents | 1989 |
Assessment of the antiarrhythmic activity of nicorandil during myocardial ischemia and reperfusion.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Coronary Circulation; Coronary Disease; Electrocardiography; In Vitro Techniques; Lactates; Myocardial Reperfusion Injury; Niacinamide; Nicorandil; Rats; Rats, Inbred Strains; Vasodilator Agents | 1989 |
Activation of ATP-sensitive outward K+ current by nicorandil (2-nicotinamidoethyl nitrate) in isolated ventricular myocytes.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Calcium; Cells, Cultured; Cobalt; Electric Conductivity; Guinea Pigs; Heart; Heart Ventricles; Kinetics; Membrane Potentials; Niacinamide; Nicorandil; Potassium Channels; Rabbits; Vasodilator Agents; Ventricular Function | 1989 |
Effects of valinomycin on calcium mobilization in vascular smooth muscle cells induced by angiotensin II.
Topics: Angiotensin II; Animals; Benzopyrans; Calcium; Cromakalim; Endothelium, Vascular; Ethers; Female; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Ionomycin; Ionophores; Monensin; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Pyrroles; Rats; Valinomycin | 1989 |
Protective effect of nicorandil on postischemic function and tissue adenine nucleotides following a brief period of low-flow global ischemia in the isolated perfused rat heart.
Topics: Adenine Nucleotides; Animals; Coronary Disease; Epoprostenol; Heart; Heart Function Tests; In Vitro Techniques; Male; Monoamine Oxidase Inhibitors; Myocardium; Niacinamide; Nicorandil; Rats; Rats, Inbred Strains; Time Factors | 1989 |
Interaction of potassium channel openers and blockers in canine atrial muscle.
Topics: Animals; Barium; Barium Compounds; Chlorides; Dogs; Female; Guanidines; Heart; In Vitro Techniques; Male; Myocardial Contraction; Myocardium; Niacinamide; Nicorandil; Nifedipine; Pinacidil; Potassium Channels; Quaternary Ammonium Compounds; Tetraethylammonium Compounds | 1989 |
Glibenclamide is a competitive antagonist of cromakalim, pinacidil and RP 49356 in guinea-pig pulmonary artery.
Topics: Animals; Benzopyrans; Cromakalim; Glyburide; Guanidines; Guinea Pigs; In Vitro Techniques; Male; Methylene Blue; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Picolines; Pinacidil; Potassium Channels; Potassium Chloride; Pulmonary Artery; Purinones; Pyrans; Pyrroles; Tetraethylammonium Compounds | 1989 |
Comparison of the effects of putative activators of K+ channels on pancreatic B-cell function.
Topics: Animals; Benzopyrans; Cromakalim; Diazoxide; Guanidines; In Vitro Techniques; Islets of Langerhans; Mice; Minoxidil; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Vasodilator Agents | 1989 |
Functional changes in potassium channels in aortas from rats with streptozotocin-induced diabetes.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Blood Glucose; Cromakalim; Diabetes Mellitus, Experimental; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Niacinamide; Nicorandil; Norepinephrine; Parasympatholytics; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains | 1989 |
Effect of cyclooxygenase blockade on the beneficial actions of nicorandil in the stunned myocardium of dogs.
Topics: Animals; Blood Pressure; Cardiomyopathies; Coronary Circulation; Cyclooxygenase Inhibitors; Dinoprostone; Dogs; Female; Heart Rate; Hemodynamics; In Vitro Techniques; Indomethacin; Male; Myocardial Reperfusion Injury; Niacinamide; Nicorandil; Prostaglandins; Thromboxane A2; Time Factors; Vasodilator Agents | 1989 |
Influences of psychological stress produced by intraspecies emotional communication on nicorandil plasma levels in rats.
Topics: Animal Communication; Animals; Chromatography, High Pressure Liquid; Emotions; Male; Niacinamide; Nicorandil; Rats; Rats, Inbred Strains; Spectrophotometry, Ultraviolet; Stress, Psychological | 1989 |
Effects of putative activators of K+ channels in mouse pancreatic beta-cells.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Diazoxide; Electrophysiology; Female; Glucose; Guanidines; Homeostasis; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Membrane Potentials; Mice; Minoxidil; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Rubidium Radioisotopes | 1989 |
[Protective effects of nicorandil against catecholamine induced myocardial damage under hypoxia].
Topics: Adenosine Triphosphate; Animals; Catecholamines; Cell Hypoxia; Cell Survival; Cells, Cultured; Male; Myocardium; Niacinamide; Nicorandil; Rats; Rats, Inbred Strains; Vasodilator Agents | 1989 |
Effects of the kallikrein-kinin system on phasic coronary vasospasm in dogs.
Topics: Animals; Bradykinin; Coronary Vasospasm; Coronary Vessels; Diltiazem; Dogs; Female; In Vitro Techniques; Kallikreins; Male; Niacinamide; Nicorandil; Nifedipine; Vasoconstriction; Vasodilator Agents | 1989 |
Nicorandil and cardiovascular performance in anaesthetized pigs with a concentric coronary artery stenosis.
Topics: Anesthesia; Animals; Arrhythmias, Cardiac; Coronary Disease; Heart Conduction System; Heart Function Tests; Hemodynamics; Microspheres; Niacinamide; Nicorandil; Oxygen Consumption; Regional Blood Flow; Swine | 1989 |
Chronic effects of nicorandil on exercise tolerance in patients with stable effort angina pectoris.
Topics: Adult; Angina Pectoris; Electrocardiography; Exercise; Female; Hemodynamics; Humans; Male; Middle Aged; Niacinamide; Nicorandil; Vasodilator Agents | 1989 |
Sodium channel-blocking properties of flecainide, a class IC antiarrhythmic drug, in guinea-pig papillary muscles. An open channel blocker or an inactivated channel blocker.
Topics: Action Potentials; Animals; Flecainide; Guinea Pigs; In Vitro Techniques; Male; Membrane Potentials; Niacinamide; Nicorandil; Papillary Muscles; Sodium Channels | 1989 |
Effects of nicorandil on cytosolic calcium concentrations in quin2-loaded rat aortic vascular smooth muscle cells in primary culture.
Topics: Aminoquinolines; Animals; Aorta; Caffeine; Calcium; Cells, Cultured; Cyclic GMP; Cytosol; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitroglycerin; Norepinephrine; Potassium; Rats; Rats, Inbred Strains; Vasodilator Agents | 1989 |
Prediction of the in-vitro human skin permeability of nicorandil from animal data.
Topics: Animals; Chromatography, High Pressure Liquid; Diffusion; Dogs; Guinea Pigs; In Vitro Techniques; Monoamine Oxidase Inhibitors; Niacinamide; Nicorandil; Rats; Rats, Inbred Strains; Skin Absorption; Solubility; Species Specificity; Swine; Water | 1989 |
Protection of acute ischemic myocardial injury by pharmacological intervention.
Topics: Adenosine Triphosphatases; Adrenergic alpha-Antagonists; Animals; Calcium; Calcium-Transporting ATPases; Coenzymes; Coronary Disease; Diltiazem; Dogs; Myocardium; Niacinamide; Nicorandil; Quinazolines; Sarcoplasmic Reticulum; Ubiquinone; Vasodilator Agents | 1989 |
Effects of 2-nicotinamidoethyl nitrate on agonist-sensitive Ca++ release and Ca++ entry in rabbit aorta.
Topics: Animals; Aorta; Biological Transport; Calcium; Female; Gallopamil; Ion Channels; Male; Membrane Potentials; Muscle Contraction; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nifedipine; Norepinephrine; Potassium Chloride; Rabbits | 1985 |
Comparative effects of K+ channel blockade on the vasorelaxant activity of cromakalim, pinacidil and nicorandil.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Benzopyrans; Cardiovascular Agents; Cromakalim; Guanidines; In Vitro Techniques; Male; Mesenteric Arteries; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Procaine; Pyrroles; Rabbits; Rubidium Radioisotopes; Tetraethylammonium Compounds; Vasodilator Agents | 1988 |
The negative inotropic effect of nicorandil is independent of cyclic GMP changes: a comparison with pinacidil and cromakalim in canine atrial muscle.
Topics: Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Benzopyrans; Cromakalim; Cyclic AMP; Cyclic GMP; Dogs; Female; Guanidines; In Vitro Techniques; Male; Monoamine Oxidase Inhibitors; Myocardial Contraction; Myocardium; Niacinamide; Nicorandil; Nifedipine; Pinacidil; Potassium Channels; Pyrroles; Tetraethylammonium Compounds; Vasodilator Agents | 1988 |
Stimulation of coronary guanylate cyclase by nicorandil (SG-75) as a mechanism of its vasodilating action.
Topics: Animals; Cattle; Coronary Vessels; Dose-Response Relationship, Drug; Ferricyanides; Guanylate Cyclase; Hydroquinones; In Vitro Techniques; Methylene Blue; Niacinamide; Nicorandil; Stimulation, Chemical; Sulfhydryl Compounds; Time Factors; Vasodilator Agents | 1985 |
Effect of nicorandil, N-(2-hydroxyethyl)nicotinamide nitrate, a new anti-anginal agent, on contractile responses to alpha-1- and alpha-2-adrenoceptor agonists in isolated rabbit aorta.
Topics: Adrenergic alpha-Agonists; Animals; Aorta; Azepines; Clonidine; Male; Methoxamine; Niacinamide; Nicorandil; Nifedipine; Rabbits; Vasodilation | 1986 |
Differential effects of nifedipine, nicorandil and nitroglycerin on the pressor responses elicited by selective alpha-1 and alpha-adrenoceptor agonists in conscious dogs.
Topics: Adrenergic alpha-Agonists; Animals; Azepines; Blood Pressure; Dogs; Female; Hemodynamics; Male; Niacinamide; Nicorandil; Nifedipine; Nitroglycerin; Phenylephrine; Vasodilator Agents | 1987 |
Differential inhibitory effects of nicorandil, a new antiangina agent, on the contractile responses to alpha-1- and alpha-2-adrenoceptor agonists in isolated rabbit renal and femoral arteries.
Topics: Adrenergic alpha-Agonists; Animals; Femoral Artery; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Rabbits; Renal Artery; Vasodilator Agents | 1987 |
Effects of nicorandil and verapamil, antianginal agents, on plasma digoxin concentrations in rats and dogs.
Topics: Animals; Blood Pressure; Digoxin; Dogs; Drug Interactions; Female; Heart Rate; Male; Niacinamide; Nicorandil; Rats; Rats, Inbred Strains; Vasodilator Agents; Verapamil | 1987 |
The membrane potential of vascular smooth muscle appears to modulate uptake2 of 3H-isoprenaline.
Topics: Adrenergic alpha-Antagonists; Animals; Female; In Vitro Techniques; Isoproterenol; Male; Membrane Potentials; Monoamine Oxidase Inhibitors; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Norepinephrine; Pulmonary Artery; Rabbits | 1987 |
Effects of nicorandil on isolated smooth muscle cells from guinea-pig taenia caeci.
Topics: Animals; Biological Transport, Active; Calcium; Carbachol; Cecum; Guinea Pigs; In Vitro Techniques; Membrane Potentials; Muscle Contraction; Muscle Proteins; Muscle, Smooth; Niacinamide; Nicorandil; Potassium | 1988 |
Guanylate cyclase activation by organic nitrates is not mediated via nitrite.
Topics: Enzyme Activation; Guanylate Cyclase; Isosorbide Dinitrate; Kinetics; Niacinamide; Nicorandil; Nitrates; Nitrites; Nitroglycerin; Sulfhydryl Compounds; Vasodilator Agents | 1988 |
Abolition by nicorandil of spontaneous action potentials of the small atrio-ventricular node preparation of the dog.
Topics: Action Potentials; Animals; Atrioventricular Node; Carbachol; Dogs; Heart Conduction System; In Vitro Techniques; Niacinamide; Nicorandil; Vasodilator Agents | 1985 |
[Inhibitory mechanism of nitrous compounds on vascular smooth muscle contraction].
Topics: Animals; Depression, Chemical; Ferricyanides; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitroprusside; Rabbits; Rats; Vasodilator Agents | 1985 |
[Vasorelaxing action of nicorandil, in comparison with nitroglycerin and Ca antagonists].
Topics: Animals; Aorta; Aorta, Thoracic; Calcium Channel Blockers; Diltiazem; Drug Interactions; Male; Niacinamide; Nicorandil; Nitroglycerin; Norepinephrine; Prazosin; Rats; Rats, Inbred Strains; Vasodilator Agents; Verapamil | 1986 |
Different effects of various vasodilators on autoregulation of renal blood flow in anesthetized dogs.
Topics: Animals; Blood Pressure; Diltiazem; Dogs; Female; Homeostasis; Male; Niacinamide; Nicorandil; Nitroglycerin; Nitroprusside; Papaverine; Renal Circulation; Sodium Nitrite; Vasodilator Agents | 1986 |
Vasodilating effects of nicorandil and nitroglycerin in anaesthetized open-chest dogs.
Topics: Anesthesia; Animals; Coronary Circulation; Dogs; Female; Male; Niacinamide; Nicorandil; Nitroglycerin; Renal Circulation; Vascular Resistance; Vasodilator Agents | 1986 |
Effects of nicorandil on the rhythmic contractile response of isolated miniature pig coronary artery to 3,4-diaminopyridine: comparison with nitroglycerin.
Topics: 4-Aminopyridine; Amifampridine; Aminopyridines; Animals; Coronary Vasospasm; Coronary Vessels; Female; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitroglycerin; Swine; Swine, Miniature | 1986 |
Recovery of contractile function in post-ischaemic reperfused myocardium of conscious dogs: influence of nicorandil, a new antianginal agent.
Topics: Animals; Blood Pressure; Coronary Disease; Dogs; Female; Heart; Heart Rate; Male; Myocardial Contraction; Niacinamide; Nicorandil; Perfusion; Vasodilator Agents | 1986 |
Cardiovascular effects of isosorbide dinitrate infused intravenously into anaesthetized dogs.
Topics: Animals; Blood Pressure; Coronary Circulation; Dogs; Female; Hemodynamics; Infusions, Intravenous; Isosorbide Dinitrate; Male; Niacinamide; Nicorandil; Nitroglycerin; Stroke Volume | 1986 |
Comparison of development of tolerance between nicorandil and nitroglycerin in anesthetized, open-chest dogs.
Topics: Animals; Coronary Circulation; Coronary Vessels; Dogs; Drug Interactions; Drug Tolerance; Female; Hemodynamics; Infusions, Intravenous; Injections, Intra-Arterial; Male; Niacinamide; Nicorandil; Nitroglycerin; Vasodilator Agents | 1986 |
Relaxant effects of pinacidil, nicorandil, hydralazine and nifedipine as studied in the porcine coronary artery and guinea-pig taenia coli.
Topics: Animals; Caffeine; Colon; Coronary Vessels; Female; Guanidines; Guinea Pigs; Hydralazine; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nifedipine; Pinacidil; Potassium; Swine; Vasodilator Agents | 1986 |
[Influence of antianginal drugs on Lypressin induced T-wave enhancement in the electrocardiogram of the rat].
Topics: Administration, Oral; Angina Pectoris; Animals; Coronary Vasospasm; Electrocardiography; Hypoxia; Isosorbide Dinitrate; Lypressin; Male; Molsidomine; Niacinamide; Nicorandil; Nifedipine; Nitroglycerin; Rats; Rats, Inbred Strains; Verapamil | 1986 |
[Role of calcium ion on pepsinogen secretion by organ culture of rabbit gastric mucosa].
Topics: Animals; Calcium; Gastric Mucosa; Male; Niacinamide; Nicorandil; Organ Culture Techniques; Pepsinogens; Rabbits; Verapamil | 1986 |
Effects of nicorandil on rest and effort angina unresponsive to combination therapy with a calcium antagonist and oral nitrate.
Topics: Aged; Aged, 80 and over; Angina Pectoris; Diltiazem; Drug Resistance; Drug Therapy, Combination; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Niacinamide; Nicorandil; Nifedipine; Physical Exertion; Prospective Studies; Rest; Vasodilator Agents | 1987 |
Electrophysiologic effects of nicorandil, a new antianginal agent, on action potentials and membrane currents of rabbit atrioventricular node.
Topics: Action Potentials; Animals; Atrioventricular Node; Heart Conduction System; In Vitro Techniques; Kinetics; Membrane Potentials; Niacinamide; Nicorandil; Potassium; Rabbits; Vasodilator Agents | 1987 |
Possible cellular mechanism for cerebral vasospasm after experimental subarachnoid hemorrhage in the dog.
Topics: Action Potentials; Animals; Biomechanical Phenomena; Cerebral Angiography; Dogs; Homeostasis; Ischemic Attack, Transient; Membrane Potentials; Niacinamide; Nicorandil; Osmolar Concentration; Potassium; Subarachnoid Hemorrhage | 1987 |
Salutary action of nicorandil, a new antianginal drug, on myocardial metabolism during ischemia and on postischemic function in a canine preparation of brief, repetitive coronary artery occlusions: comparison with isosorbide dinitrate.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Animals; Coronary Circulation; Coronary Disease; Dogs; Energy Metabolism; Fatty Acids, Nonesterified; Female; Glucose; Hemodynamics; Isosorbide Dinitrate; Male; Myocardium; Niacinamide; Nicorandil; Oxygen; Recurrence | 1987 |
Differential effects of isoproterenol on the canine atrial action potential in the presence of carbachol or nicorandil.
Topics: Action Potentials; Animals; Carbachol; Dogs; Drug Interactions; Female; Heart; In Vitro Techniques; Isoproterenol; Male; Niacinamide; Nicorandil | 1987 |
Nicorandil-induced changes in the distribution of cardiac output and coronary blood flow in pigs.
Topics: Animals; Cardiac Output; Coronary Circulation; Female; Hemodynamics; Male; Myocardium; Niacinamide; Nicorandil; Oxygen Consumption; Propranolol; Regional Blood Flow; Swine; Vasodilator Agents | 1987 |
[Antiarrhythmic effects of nicorandil].
Topics: Animals; Arrhythmias, Cardiac; Female; Guinea Pigs; Male; Mice; Niacinamide; Nicorandil; Rabbits; Rats; Rats, Inbred Strains; Ventricular Fibrillation | 1987 |
Anti-spasmogenic and spasmolytic effects of BRL 34915: a comparison with nifedipine and nicorandil.
Topics: Animals; Benzopyrans; Cromakalim; Electric Stimulation; In Vitro Techniques; Male; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nifedipine; Norepinephrine; Parasympatholytics; Potassium Chloride; Pyrroles; Rabbits | 1987 |
Examination of the direct effects of antianginal agents on the hypoxic canine myocardium.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Cardiomyopathies; Coronary Circulation; Dogs; Female; Hypoxia; Male; Myocardial Contraction; Myocardium; Niacinamide; Nicorandil; Nitroglycerin; Vasodilator Agents | 1987 |
Coronary vasodilatory action after a single dose of nicorandil.
Topics: Adult; Aged; Blood Pressure; Coronary Angiography; Coronary Circulation; Coronary Disease; Coronary Vessels; Female; Humans; Male; Middle Aged; Myocardium; Niacinamide; Nicorandil; Oxygen Consumption; Vascular Resistance; Vasodilation; Vasodilator Agents | 1988 |
Comparative vasorelaxing profiles of nicorandil, isosorbide dinitrate and nitroglycerin in isolated coronary arteries of the dog.
Topics: Acetylcysteine; Animals; Coronary Vessels; Dinoprost; Dogs; Endothelium; Female; In Vitro Techniques; Isosorbide Dinitrate; Male; Methylene Blue; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitroglycerin; Potassium Chloride; Prostaglandins F; Vasodilator Agents | 1987 |
Effects of nicorandil on large epicardial coronary artery in conscious dogs.
Topics: Animals; Coronary Circulation; Dogs; Hemodynamics; Niacinamide; Nicorandil; Vasodilator Agents | 1987 |
Nicorandil shortens action potential duration and antagonises the reduction of Vmax by lidocaine but not by disopyramide in guinea-pig papillary muscles.
Topics: Action Potentials; Animals; Disopyramide; Guinea Pigs; In Vitro Techniques; Lidocaine; Male; Membrane Potentials; Niacinamide; Nicorandil; Papillary Muscles; Vasodilator Agents | 1988 |
Experimental studies on ischemic injury and reperfusion injury to the cardiac sarcoplasmic reticulum--the myocardial protective effect of nicorandil.
Topics: Animals; Blood Pressure; Calcium; Cardiac Output; Cardioplegic Solutions; Cardiopulmonary Bypass; Coronary Disease; Dogs; Heart Rate; Myocardial Reperfusion; Myocardial Reperfusion Injury; Myocardium; Niacinamide; Nicorandil; Sarcoplasmic Reticulum | 1988 |
Characteristics of cromakalim-induced relaxations in the smooth muscle cells of guinea-pig mesenteric artery and vein.
Topics: Action Potentials; Animals; Antihypertensive Agents; Benzopyrans; Cromakalim; Female; Guinea Pigs; In Vitro Techniques; Male; Membrane Potentials; Mesenteric Arteries; Mesenteric Veins; Microelectrodes; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Potassium Channels; Pyrroles; Vasodilator Agents | 1988 |
[Accelerated myocardial metabolic and functional recovery with terminal nicorandil-mg cardioplegia in experimental heart transplantation].
Topics: Animals; Cardioplegic Solutions; Dogs; Heart; Heart Arrest, Induced; Heart Transplantation; Magnesium; Myocardial Reperfusion Injury; Myocardium; Niacinamide; Nicorandil; Oxygen Consumption | 1988 |
Estimation of blood concentration of drugs after topical application from in vitro skin permeation data. I. Prediction by convolution and confirmation by deconvolution.
Topics: Administration, Topical; Animals; Male; Niacinamide; Nicorandil; Pharmaceutical Preparations; Rats; Rats, Inbred Strains; Skin Absorption | 1988 |
The effects of vasoactive agents on the proliferation of vascular smooth muscle cells grown in vitro.
Topics: Amiloride; Animals; Captopril; Cell Division; Cells, Cultured; Chlorpromazine; In Vitro Techniques; Labetalol; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nifedipine; Norepinephrine; Propranolol; Quinazolines; Rats; Sulfonamides | 1988 |
Tetraethylammonium-induced contraction of rabbit coronary artery.
Topics: Animals; Arteries; Coronary Vessels; Ergonovine; Isoproterenol; Muscle Contraction; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitroglycerin; Rabbits; Tetraethylammonium Compounds; Vasoconstriction | 1988 |
The relationship between tissue levels of cyclic GMP and tracheal smooth muscle relaxation in the guinea-pig.
Topics: Animals; Cyclic GMP; Dose-Response Relationship, Drug; Guinea Pigs; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Niacinamide; Nicorandil; Nitroprusside; Trachea | 1986 |
Mechanisms of tetraethylammonium-induced contraction in the canine coronary artery.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Calcium; Cesium; Chlorides; Coronary Vessels; Dogs; Female; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Phenylephrine; Potassium; Tetraethylammonium Compounds; Vasodilator Agents; Verapamil | 1986 |
Decreasing potassium conductance--a possible mechanism of phasic coronary vasospasm.
Topics: 4-Aminopyridine; Amifampridine; Aminopyridines; Animals; Calcium; Coronary Vasospasm; Coronary Vessels; Dogs; Ergonovine; Female; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Macaca mulatta; Male; Membrane Potentials; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Myocardium; Niacinamide; Nicorandil; Nifedipine; Potassium; Swine; Tetraethylammonium; Tetraethylammonium Compounds | 1985 |
Abolition of spontaneous rhythmic contractions of isolated monkey coronary arteries by diltiazem, nifedipine, verapamil and nicorandil but not by nitroglycerin.
Topics: Animals; Calcium Channel Blockers; Coronary Vessels; Diltiazem; Erythrocebus patas; Female; In Vitro Techniques; Macaca mulatta; Male; Muscle Contraction; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nifedipine; Nitroglycerin; Verapamil | 1985 |
Protective effects of the antianginal agent nicorandil on arachidonate-induced sudden death in rats: comparison with several antianginal agents and cyclooxygenase inhibitors.
Topics: Angina Pectoris; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Cyclooxygenase Inhibitors; Death, Sudden; Diltiazem; Indomethacin; Male; Mice; Niacinamide; Nicorandil; Nitroglycerin; Rats; Rats, Inbred Strains; Vasodilator Agents | 1985 |
Vasodilative effect of nicorandil on coronary artery.
Topics: Animals; Coronary Vessels; Dinoprost; Dogs; Female; Male; Muscle Relaxation; Niacinamide; Nicorandil; Potassium; Prostaglandins F; Vasodilator Agents; Verapamil | 1985 |
Effectiveness of nicorandil in the preservation of myocardium stressed by transient ischemia and its influence on cardiac metabolism during coronary artery occlusion with subsequent reperfusion: a comparison with isosorbide dinitrate.
Topics: Animals; Coronary Disease; Coronary Vessels; Dogs; Fatty Acids, Nonesterified; Glucose; Heart; Hemodynamics; Isosorbide Dinitrate; Lactates; Lactic Acid; Ligation; Myocardium; Niacinamide; Nicorandil; Perfusion | 1985 |
Hypotensive effects and biotransformation of nicorandil, a new antianginal agent, administered to rats by different routes: comparison with nitroglycerin and isosorbide dinitrate.
Topics: Animals; Antihypertensive Agents; Biotransformation; Blood Pressure; Dogs; Guinea Pigs; In Vitro Techniques; Isosorbide Dinitrate; Liver; Macaca mulatta; Male; Niacinamide; Nicorandil; Nitroglycerin; Rats; Rats, Inbred Strains; Swine; Vasodilator Agents | 1984 |
Effects of 2-nicotinamidoethyl nitrate on smooth muscle cells of the guinea-pig mesenteric and portal veins.
Topics: Acetylcholine; Animals; Female; Guinea Pigs; In Vitro Techniques; Male; Membrane Potentials; Membranes; Mesenteric Veins; Muscle Contraction; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitrates; Nitroglycerin; Norepinephrine; Portal Vein; Vasodilator Agents | 1982 |
Effects of 4-aminopyridine and tetraethylammonium on relaxant responses of isolated dog coronary arteries to 2-nicotinamidoethyl nitrate (SG-75).
Topics: 4-Aminopyridine; Aminopyridines; Animals; Coronary Vessels; Dinoprost; Dogs; Female; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Niacinamide; Nicorandil; Nitrates; Potassium; Prostaglandins F; Tetraethylammonium Compounds; Vasoconstriction | 1982 |
SG-75 induction of increased coronary outflow and PGE1 from ischemic areas in dogs with experimental myocardial infarction.
Topics: Alprostadil; Animals; Coronary Circulation; Dinoprostone; Dogs; Indomethacin; Lactates; Myocardial Infarction; Myocardium; Niacinamide; Nicorandil; Prostaglandins E; Vasodilator Agents | 1982 |
Effects of nicorandil and its congeners on musculature and vasculature of the dog trachea in situ.
Topics: Animals; Dogs; Female; In Vitro Techniques; Male; Muscle, Smooth; Niacinamide; Nicorandil; Regional Blood Flow; Trachea; Vasodilator Agents | 1982 |
[Efficacy of nicorandil (SG-75), a substance with nitro-properties and long-term effects in coronary patients: improvement of LV-function and wall motility without pacing-induced myocardial ischemia].
Topics: Aged; Angiography; Cardiac Pacing, Artificial; Coronary Disease; Heart Ventricles; Hemodynamics; Humans; Middle Aged; Myocardial Contraction; Niacinamide; Nicorandil; Oxygen Consumption | 1982 |
Effects of 2-nicotinamidoethyl nitrate (SG-75, nicorandil) on indomethacin-induced contractions of isolated dog coronary arteries.
Topics: Animals; Coronary Vessels; Depression, Chemical; Dogs; Epoprostenol; In Vitro Techniques; Indomethacin; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Tranylcypromine | 1983 |
Effects of a new antianginal agent, nicorandil, on the cardiovascular system of the miniature pig: with special reference to coronary vasospasm.
Topics: Animals; Blood Pressure; Cardiovascular System; Coronary Circulation; Coronary Vasospasm; Dipyridamole; Female; Male; Myocardium; Niacinamide; Nicorandil; Nitroglycerin; Oxygen Consumption; Swine; Swine, Miniature; Vascular Resistance; Vasomotor System | 1983 |
Mechanism of relaxant effects of nicorandil on the dog coronary artery.
Topics: Animals; Caffeine; Calcium; Coronary Vessels; Dogs; Female; Lanthanum; Male; Niacinamide; Nicorandil; Nifedipine; Nitroglycerin; Potassium; Vasoconstriction; Vasodilation; Vasodilator Agents | 1983 |
Effects of a new antianginal agent, nicorandil, on normoxic and anoxic contractions in isolated miniature pig coronary arteries exposed to 5-hydroxytryptamine and norepinephrine: comparison with nitroglycerin and diltiazem.
Topics: Animals; Benzazepines; Coronary Vessels; Diltiazem; Drug Interactions; Female; Male; Muscle Contraction; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitroglycerin; Norepinephrine; Oxygen; Serotonin Antagonists; Swine; Swine, Miniature | 1983 |
Nicorandil attenuates myocardial acidosis during coronary occlusion in dogs.
Topics: Acidosis; Animals; Coronary Disease; Dogs; Female; Heart Diseases; Male; Niacinamide; Nicorandil; Vasodilator Agents | 1984 |
Effects of nicorandil, a new antianginal agent, and nifedipine on collateral blood flow in a chronic coronary occlusion model.
Topics: Animals; Collateral Circulation; Coronary Circulation; Coronary Disease; Disease Models, Animal; Dogs; Female; Hemodynamics; Male; Niacinamide; Nicorandil; Nifedipine; Vasodilator Agents | 1984 |
Effects of vasodilators on the systemic capacitance vessels, a study with the measurement of the mean circulatory pressure in dogs.
Topics: Animals; Blood Pressure; Blood Vessels; Blood Volume; Cardiac Output; Diltiazem; Dogs; Heart Rate; Isosorbide Dinitrate; Molsidomine; Niacinamide; Nicorandil; Nifedipine; Nitroglycerin; Prazosin; Sydnones; Trapidil; Vascular Resistance; Vasodilator Agents; Venous Pressure; Verapamil | 1984 |
Pharmacokinetics of nicorandil, a new coronary vasodilator, in dogs.
Topics: Administration, Oral; Animals; Chromatography, High Pressure Liquid; Dogs; Half-Life; Injections, Intravenous; Kinetics; Niacinamide; Nicorandil; Vasodilator Agents | 1984 |
Effects of 2-nicotinamidoethyl nitrate (nicorandil; SG-75) and its derivative on smooth muscle cells of the canine mesenteric artery.
Topics: Animals; Calcium; Dogs; Evoked Potentials; Female; Male; Membrane Potentials; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Norepinephrine; Vasodilator Agents | 1984 |
Comparative effects of nicorandil and nitroglycerin on tracheal and vascular smooth muscle in the dog, in vivo and in vitro.
Topics: Animals; Coronary Vessels; Dogs; Dose-Response Relationship, Drug; Female; Hemodynamics; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitroglycerin; Potassium Chloride; Regional Blood Flow; Trachea; Vasodilator Agents | 1984 |
Effects of nicorandil on the membrane currents of rabbit sino-atrial node cells.
Topics: Action Potentials; Animals; Female; In Vitro Techniques; Male; Membrane Potentials; Niacinamide; Nicorandil; Rabbits; Sinoatrial Node; Vasodilator Agents | 1984 |
Relaxing effect of nicorandil (N-2-(hydroxyethyl)-nicotinamide nitrate), a new anti-angina agent, on the isolated vascular smooth muscle.
Topics: Animals; Aorta, Thoracic; Basilar Artery; Calcium; Cats; Coronary Vessels; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nifedipine; Nitroglycerin; Norepinephrine; Potassium Chloride; Rabbits; Vasodilator Agents | 1984 |
Effects of 2-nicotinamidoethyl nitrate (Nicorandil) on excitation-contraction coupling in the smooth muscle cells of rabbit ear artery.
Topics: Animals; Calcium; Ear; Electric Stimulation; Evoked Potentials; Female; Male; Membrane Potentials; Muscle Contraction; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Norepinephrine; Potassium; Rabbits; Vasodilator Agents | 1984 |
Nicorandil releases acetylcholine-induced sustained coronary arterial constriction in monkeys and baboons.
Topics: Acetylcholine; Animals; Coronary Circulation; Coronary Vasospasm; Disease Models, Animal; Dose-Response Relationship, Drug; Infusions, Parenteral; Injections; Macaca; Macaca mulatta; Male; Niacinamide; Nicorandil; Papio | 1984 |
The effects of dilazep and SG 75 on cyclic nucleotides in the coronary artery.
Topics: Adenosine; Animals; Arteries; Azepines; Coronary Circulation; Coronary Vessels; Cyclic AMP; Cyclic GMP; Dilazep; Dogs; Muscle Contraction; Myocardium; Niacinamide; Nicorandil; Nitrates; Vasodilator Agents | 1980 |
Effects of 2-nicotinamidethyl nitrate (SG-75), a new antianginal drug, on the cyclic AMP phosphodiesterase activity.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Niacinamide; Nicorandil; Nitrates; Papaverine; Vasodilator Agents | 1980 |
Effects of 2-nicotinamidoethyl nitrate on smooth muscle cells and on adrenergic transmission in the guinea-pig and porcine mesenteric arteries.
Topics: Action Potentials; Animals; Female; Guinea Pigs; In Vitro Techniques; Male; Membrane Potentials; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitrates; Nitrites; Norepinephrine; Potassium; Swine; Sympathetic Nervous System; Synaptic Transmission; Vasodilator Agents | 1981 |
Effects of SG-75 (nicorandil) on electrical activity of canine cardiac Purkinje fibers: possible increase in potassium conductance.
Topics: Action Potentials; Animals; Atropine; Barium; Dogs; Electrophysiology; Female; Heart Conduction System; Ion Channels; Male; Niacinamide; Nicorandil; Potassium; Purkinje Fibers; Solutions; Stress, Mechanical; Verapamil | 1983 |
Relationship between relaxation and cyclic GMP formation caused by nicorandil in canine mesenteric artery.
Topics: Animals; Cyclic GMP; Dogs; In Vitro Techniques; Mesenteric Arteries; Niacinamide; Nicorandil; Norepinephrine; Vasodilation; Vasodilator Agents | 1983 |
The effects of 2-nicotinamidoethyl nitrate on smooth muscle cells of the dog mesenteric artery and trachea.
Topics: Animals; Calcium; Dogs; Female; In Vitro Techniques; Male; Membrane Potentials; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth; Niacinamide; Nicorandil; Synaptic Transmission; Tetraethylammonium Compounds; Trachea; Vasodilator Agents | 1983 |
Enhancement of PGI2 formation by a new vasodilator, 2-nicotinamidoethyl nitrate in the coupled system of platelets and aortic microsomes.
Topics: Animals; Aorta; Arachidonic Acids; Blood Platelets; Epoprostenol; In Vitro Techniques; Microsomes; Niacinamide; Nicorandil; Nitrates; Prostaglandins; Rats; Thromboxane A2; Vasodilator Agents | 1980 |
Effect of 2-nicotinamidethyl nitrate (SG-75) on the membrane potential of left atrial muscle fibres of the dog. Increase in potassium conductance.
Topics: Animals; Atropine; Chlorides; Dogs; Drug Interactions; Heart; In Vitro Techniques; Membrane Potentials; Methacholine Compounds; Neural Conduction; Niacinamide; Nicorandil; Nitrates; Ouabain; Potassium; Vasodilator Agents; Verapamil | 1980 |
Vasodilating actions of 2-nicotinamidoethyl nitrate on porcine and guinea-pig coronary arteries.
Topics: Animals; Coronary Vessels; Female; Guinea Pigs; In Vitro Techniques; Male; Membrane Potentials; Microelectrodes; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitrates; Potassium; Species Specificity; Swine; Vasodilator Agents | 1981 |
Pharmacodynamic and metabolism studies on a new coronary vasodilator, N-(2-hydroxyethyl) nicotinamide nitrate (SG-75).
Topics: Animals; Blood Pressure; Coronary Vessels; Heart Rate; In Vitro Techniques; Intestinal Absorption; Male; Niacinamide; Nicorandil; Nitrates; Perfusion; Rats; Vasodilator Agents | 1980 |
Effects of 2-nicotinamidethyl nitrate (SG-75) and/or nitroglycerin on systemic hemodynamics and coronary blood flow in conscious dogs.
Topics: Animals; Blood Pressure; Coronary Circulation; Dogs; Heart Rate; Hemodynamics; Niacinamide; Nicorandil; Nitrates; Nitroglycerin; Vascular Resistance; Vasodilator Agents | 1981 |
[Studies on the relation between collateral development and the effects of antianginal drugs--effects of nitroglycerin and 2-nicotinamidethyl nitrate on collateral circulation (author's transl)].
Topics: Angina Pectoris; Animals; Collateral Circulation; Coronary Circulation; Dogs; Niacinamide; Nicorandil; Nitrates; Nitroglycerin | 1981 |
Effects of a new coronary vasodilator, N-(2-hydroxyethyl)nicotinamide nitrate (SG-75) and nitroglycerin on cardiovascular hemodynamics in young and aged beagle dogs.
Topics: Age Factors; Animals; Dogs; Dose-Response Relationship, Drug; Female; Hemodynamics; Male; Niacinamide; Nicorandil; Nitrates; Nitroglycerin; Vasodilator Agents | 1981 |
Effect of 2-nicotinamidethyl nitrate (SG-75) on membrane potentials of canine Purkinje fibers.
Topics: Animals; Dogs; Dose-Response Relationship, Drug; Electric Stimulation; Heart Conduction System; In Vitro Techniques; Membrane Potentials; Niacinamide; Nicorandil; Nitrates; Purkinje Fibers; Vasodilator Agents | 1981 |
Effects of N-(2-hydroxyethyl)nicotinamide nitrate (SG-75) on methacholine-induced ECG changes in intact anesthetized rats.
Topics: Acetylcholine; Anesthesia; Angina Pectoris; Animals; Blood Pressure; Brain; Electrocardiography; Heart; Male; Methacholine Compounds; Niacinamide; Nicorandil; Nitrates; Rats; Rats, Inbred Strains; Vasodilator Agents | 1981 |
The dose of nicorandil in men predicted from the inhibition of MAO activity by organic nitrates.
Topics: Animals; In Vitro Techniques; Kinetics; Male; Mitochondria, Liver; Monoamine Oxidase Inhibitors; Niacinamide; Nicorandil; Nitrates; Rats; Rats, Inbred Strains; Tryptamines | 1981 |
The hypotensive mechanisms of the new anti-anginal drug, N-(2-hydroxyethyl)nicotinamide nitrate (SG-75) in beagle dogs.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Coronary Circulation; Dogs; Female; Heart Rate; Male; Niacinamide; Nicorandil; Nitrates; Vascular Resistance; Vasodilator Agents | 1981 |
Nicorandil suppresses a hump on the monophasic action potential and torsade de pointes in a patient with idiopathic long QT syndrome.
Topics: Action Potentials; Aged; Anti-Arrhythmia Agents; Female; Humans; Long QT Syndrome; Niacinamide; Nicorandil; Torsades de Pointes | 1995 |
Protective effect of nicorandil as an additive to the solution for continuous warm cardioplegia.
Topics: Animals; Cardioplegic Solutions; Coronary Circulation; Dose-Response Relationship, Drug; Heart; Heart Arrest, Induced; Male; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion; Myocardial Reperfusion Injury; Niacinamide; Nicorandil; Rats; Rats, Wistar; Ventricular Fibrillation | 1995 |
Effects of ATP-sensitive K+ channel openers on pacemaker activity in isolated single rabbit sino-atrial node cells.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Electrophysiology; Glyburide; Guanidines; Heart Rate; In Vitro Techniques; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Rabbits; Sinoatrial Node; Vasodilator Agents | 1993 |
Antiplatelet effects of a novel antianginal agent, nicorandil.
Topics: Acetylcysteine; Adenosine Diphosphate; Analysis of Variance; Binding Sites; Blood Platelets; Cyclic GMP; Dose-Response Relationship, Drug; Drug Tolerance; Fibrinogen; Guanylate Cyclase; Humans; Niacinamide; Nicorandil; Platelet Aggregation; Platelet Aggregation Inhibitors; Potassium Channels; Radioimmunoassay; Vasodilator Agents | 1994 |
Glibenclamide-induced oscillation of canine coronary artery is independent of myocardial ischemia.
Topics: Adenosine Triphosphate; Animals; Arginine; Benzopyrans; Coronary Circulation; Coronary Vessels; Cromakalim; Diltiazem; Dogs; Female; Glyburide; In Vitro Techniques; Male; Muscle Tonus; Muscle, Smooth, Vascular; Myocardial Ischemia; Niacinamide; Nicorandil; Nitroarginine; Nitroglycerin; Potassium Channels; Pyrroles; Vasodilator Agents | 1994 |
Comparative study on the effects of intracoronary nicorandil and nitroglycerin in ischaemic, reperfused porcine hearts.
Topics: Animals; Female; Hemodynamics; Injections, Intra-Arterial; Male; Niacinamide; Nicorandil; Nitroglycerin; Oxygen Consumption; Potassium Channels; Reperfusion Injury; Swine; Vasodilator Agents | 1995 |
Nicorandil suppressed myocardial purine metabolism during exercise in patients with angina pectoris.
Topics: Administration, Oral; Aged; Angina Pectoris; Blood Pressure; Energy Metabolism; Exercise; Female; Heart; Heart Rate; Humans; Male; Middle Aged; Niacinamide; Nicorandil; Placebo Effect; Purines; Time Factors; Vasodilator Agents | 1995 |
Effects of nicorandil on left ventricular systolic and diastolic function in patients with hypertrophic cardiomyopathy.
Topics: Adult; Aged; Cardiomyopathy, Hypertrophic; Diastole; Echocardiography, Doppler; Female; Humans; Male; Middle Aged; Niacinamide; Nicorandil; Radionuclide Angiography; Systole; Vasodilator Agents; Ventricular Function, Left | 1995 |
[Effect of potassium channel opener, Nicorandil, on cochlear electrical potentials in the guinea pig].
Topics: Animals; Cochlear Microphonic Potentials; Dose-Response Relationship, Drug; Guinea Pigs; Niacinamide; Nicorandil; Potassium Channels; Vasodilator Agents | 1995 |
[The effect of nicorandil on the neuromuscular block induced by vecuronium].
Topics: Animals; Electric Stimulation; Male; Neuromuscular Blocking Agents; Niacinamide; Nicorandil; Phrenic Nerve; Rats; Vecuronium Bromide | 1995 |
Effect of four potassium channel agonists on bupivacaine-induced toxicity in mice.
Topics: Animals; Benzopyrans; Bupivacaine; Cromakalim; Diazoxide; Dose-Response Relationship, Drug; Guanidines; Male; Mice; Mice, Inbred Strains; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Seizures | 1995 |
Early afterdepolarization abolished by potassium channel opener in a patient with idiopathic long QT syndrome.
Topics: Action Potentials; Adolescent; Anti-Arrhythmia Agents; Electrocardiography; Humans; Long QT Syndrome; Male; Niacinamide; Nicorandil; Potassium Channels; Syncope | 1995 |
Hemodynamic tolerance and pharmacokinetics of nicorandil in experimental heart failure.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Chromatography, High Pressure Liquid; Heart Failure; Heart Rate; Hemodynamics; Male; Niacinamide; Nicorandil; Rats; Rats, Sprague-Dawley | 1993 |
Hemodynamic profile of KRN2391, a novel vasodilator, in anesthetized dogs.
Topics: Anesthesia; Animals; Blood Pressure; Cerebrovascular Circulation; Coronary Circulation; Dogs; Female; Heart Rate; Hemodynamics; In Vitro Techniques; Injections, Intra-Arterial; Injections, Intravenous; Male; Niacinamide; Nicorandil; Nifedipine; Pyridines; Regional Blood Flow; Renal Circulation; Splanchnic Circulation; Vascular Resistance; Vasodilator Agents | 1993 |
Effects of KRN2391, nicorandil and diltiazem on the changes in the electrocardiogram caused by endothelin-1 in anaesthetized rats.
Topics: Action Potentials; Anesthesia; Animals; Blood Pressure; Cardiac Complexes, Premature; Diltiazem; Electrocardiography; Electrophysiology; Endothelins; Glyburide; Guinea Pigs; Heart Rate; In Vitro Techniques; Male; Methacholine Compounds; Niacinamide; Nicorandil; Pyridines; Rats; Rats, Wistar; Vasodilator Agents; Ventricular Fibrillation | 1993 |
Effect of KRN2391 on venous return: comparison with other vasodilators.
Topics: Animals; Benzopyrans; Cromakalim; Dogs; Female; Glyburide; Hemodynamics; Male; Niacinamide; Nicorandil; Nifedipine; Nitroglycerin; Potassium Channels; Pyridines; Pyrroles; Vasodilator Agents; Veins | 1993 |
The inhibitory mechanisms of nicorandil in isolated rat urinary bladder and femoral artery.
Topics: Acetylcholine; Animals; Benzopyrans; Cromakalim; Cyclic GMP; Electric Stimulation; Femoral Artery; Guanylate Cyclase; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitroglycerin; Potassium Channels; Potassium Chloride; Pyrroles; Rats; Rats, Wistar; Urinary Bladder; Vasodilator Agents | 1995 |
The risk of myocardial stunning is decreased concentration-dependently by KATP channel activation with nicorandil before high K+ cardioplegia.
Topics: Adenosine Triphosphate; Animals; Cardioplegic Solutions; Cardiotonic Agents; Combined Modality Therapy; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Glyburide; Guinea Pigs; Heart Arrest, Induced; Hypothermia, Induced; Isotonic Solutions; Models, Cardiovascular; Multivariate Analysis; Myocardial Contraction; Myocardial Stunning; Niacinamide; Nicorandil; Potassium Channels; Pressure; Risk Factors; Time Factors; Vasodilator Agents | 1995 |
The effects of potassium channel openers and blockers on the specific binding sites for [3H]glibenclamide in rat tissues.
Topics: Animals; Binding Sites; Brain; Cell Membrane; Dose-Response Relationship, Drug; Glyburide; Heart Ventricles; Male; Muscle Contraction; Niacinamide; Nicorandil; Oxadiazoles; Piperidines; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Wistar; Rubidium; Vasodilator Agents | 1995 |
Potentiating effect of nicorandil, an antianginal agent, on relaxation induced by isoproterenol in isolated rat aorta: involvement of cyclic GMP-inhibitable cyclic AMP phosphodiesterase.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Angina Pectoris; Animals; Aorta; Cyclic AMP; Cyclic GMP; Drug Synergism; In Vitro Techniques; Isoproterenol; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Rats; Rats, Wistar; Vasodilator Agents | 1995 |
Effect of nicorandil on cardiac dysfunction during reperfusion in normotensive and spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Coronary Circulation; Creatine Kinase; Dose-Response Relationship, Drug; Heart; Heart Rate; Hemodynamics; Hypertension; Male; Myocardial Reperfusion; Niacinamide; Nicorandil; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Reference Values; Ventricular Function, Left | 1995 |
Effects of nicorandil and glyceryl trinitrate on infarct size, adenosine release, and neutrophil infiltration in the dog.
Topics: Adenosine; Animals; Cell Movement; Coronary Circulation; Dogs; Female; Male; Myocardial Infarction; Myocardial Reperfusion; Myocardium; Neutrophils; Niacinamide; Nicorandil; Nitroglycerin; Peroxidase; Regional Blood Flow; Vasodilator Agents | 1995 |
Antioxidative action of the nitrovasodilator nicorandil: inhibition of oxidative activation of liver microsomal glutathione S-transferase and lipid peroxidation.
Topics: Animals; Antioxidants; Dose-Response Relationship, Drug; Enzyme Activation; Glutathione Transferase; Isosorbide Dinitrate; Lipid Peroxidation; Male; Microsomes, Liver; Niacinamide; Nicorandil; Nitroglycerin; Oxidation-Reduction; Propanolamines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Structure-Activity Relationship; Sympathetic Nervous System; Vasodilator Agents | 1994 |
[Therapeutic application of myocardial cytoprotection].
Topics: Acetanilides; Adrenergic beta-Antagonists; Angina Pectoris; Calcium Channel Blockers; Carnitine; Humans; Myocardial Ischemia; Niacinamide; Nicorandil; Piperazines; Ranolazine; Trimetazidine; Vasodilator Agents | 1994 |
Effects of a novel, selective and potent phosphodiesterase type V inhibitor, E4021, on myocardial ischemia in guinea pigs.
Topics: Animals; Drug Interactions; Electrocardiography; Guinea Pigs; Injections, Intravenous; Isosorbide Dinitrate; Male; Myocardial Ischemia; Niacinamide; Nicorandil; Nitro Compounds; Phosphodiesterase Inhibitors; Piperidines; Quinazolines; Vasodilator Agents; Vasopressins | 1994 |
Ionic dependence of adenosine uptake into cultured astrocytes.
Topics: Adenosine; Animals; Animals, Newborn; Astrocytes; Benzopyrans; Biological Transport; Calcimycin; Calcium; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cells, Cultured; Cerebral Cortex; Cromakalim; Furosemide; Glyburide; Ionophores; Kinetics; Mice; Niacinamide; Nicorandil; Nigericin; Omeprazole; Potassium; Pyrroles; Sodium; Valinomycin; Vasodilator Agents | 1994 |
New antianginal nitro esters with reduced hypotensive activity. Synthesis and pharmacological evaluation of 3-[(nitrooxy)alkyl]-2H-1,3-benzoxazin-4(3H)-ones.
Topics: Angina Pectoris; Animals; Benzoxazines; Blood Pressure; Hemodynamics; Hypotension; In Vitro Techniques; Ischemia; Male; Niacinamide; Nicorandil; Nitrates; Nitroglycerin; Oxazines; Rabbits; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Vasodilator Agents | 1995 |
Potassium channel opener, RP 66471, induces membrane depolarization of rat liver mitochondria.
Topics: Animals; Antihypertensive Agents; Benzoates; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Fluoresceins; Fluorescent Dyes; Hydrogen-Ion Concentration; Intracellular Membranes; Ion Channel Gating; Kinetics; Light; Lipid Bilayers; Membrane Potentials; Mitochondria, Liver; Niacinamide; Nicorandil; Potassium; Potassium Channels; Pyridines; Rats; Scattering, Radiation; Valinomycin | 1995 |
Comparisons of the effects of nicorandil, pinacidil, nicardipine and nitroglycerin on coronary vessels in the conscious dog: role of the endothelium.
Topics: Acetylcholine; Animals; Blood Pressure; Coronary Circulation; Coronary Vessels; Dogs; Endothelium, Vascular; Guanidines; Heart Rate; Niacinamide; Nicardipine; Nicorandil; Nitroglycerin; Pinacidil; Vascular Resistance; Vasodilator Agents | 1995 |
In vitro evaluation of nicorandil, diltiazem, and prostaglandin E1 on hypothermic injury to immature myocytes.
Topics: Alprostadil; Animals; Animals, Newborn; Cell Death; Cells, Cultured; Cold Temperature; Creatine Kinase; Diltiazem; Female; Heart Rate; Heart Ventricles; L-Lactate Dehydrogenase; Myocardium; Niacinamide; Nicorandil; Rats; Rats, Wistar; Ventricular Function | 1995 |
Potassium channel openers relax A23187-induced nifedipine-resistant contraction of rat aorta.
Topics: Animals; Aorta; Benzopyrans; Calcimycin; Cromakalim; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nifedipine; Oxadiazoles; Piperidines; Pyrroles; Rats; Rats, Wistar; Vasoconstriction; Vasodilator Agents | 1994 |
The contribution of guanylate cyclase stimulation and K+ channel opening to nicorandil-induced vasorelaxation depends on the conduit vessel and on the nature of the spasmogen.
Topics: Animals; Aorta; Enzyme Activation; Guanylate Cyclase; In Vitro Techniques; Male; Mesenteric Arteries; Muscle Contraction; Niacinamide; Nicorandil; Nitroglycerin; Norepinephrine; Picolines; Potassium Channels; Potassium Chloride; Pulmonary Artery; Pyrans; Rabbits; Vascular Resistance; Vasodilator Agents | 1994 |
A further study of the vasodilator and negative inotropic mechanisms of action of nicorandil and its congeners in the canine heart.
Topics: Animals; Coronary Circulation; Depression, Chemical; Dogs; Drug Interactions; Female; Glyburide; Heart; In Vitro Techniques; Male; Myocardial Contraction; Niacinamide; Nicorandil; Papillary Muscles; Potassium Channels; Vasodilator Agents | 1994 |
Intracellular acidification and ADP enhance nicorandil induction of ATP sensitive potassium channel current in cardiomyocytes.
Topics: Action Potentials; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Cells, Cultured; Guanidines; Guinea Pigs; Hydrogen-Ion Concentration; Membrane Potentials; Myocardium; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Protons; Vasodilator Agents | 1994 |
Long term increases in coronary arterial conductance during five day infusion of low dose nicorandil.
Topics: Animals; Coronary Vessels; Dogs; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Delivery Systems; Female; Male; Niacinamide; Nicorandil; Nitroglycerin; Time Factors; Vasodilator Agents | 1994 |
Inhibitory effects of nicorandil on sympathetic coronary vasoconstriction.
Topics: Animals; Arginine; Coronary Vessels; Dogs; Electric Stimulation; Neuropeptide Y; Niacinamide; Nicorandil; Nitroarginine; Nitroglycerin; Norepinephrine; Sympathetic Nervous System; Vascular Resistance; Vasoconstriction | 1994 |
Cytoprotective effects of nicorandil on hypothermic injury to immature cardiac myocytes--comparison with nitroglycerin, diltiazem and prostaglandin E1.
Topics: Alprostadil; Animals; Cells, Cultured; Cold Temperature; Creatine Kinase; Cryopreservation; Cryoprotective Agents; Diltiazem; Heart; L-Lactate Dehydrogenase; Myocardium; Niacinamide; Nicorandil; Nitroglycerin; Rats; Vasodilator Agents | 1994 |
A modified product inhibition model describes the nonlinear pharmacokinetics of nicorandil in rats.
Topics: Animals; Biotransformation; Chromatography, High Pressure Liquid; Computer Simulation; Half-Life; Infusions, Intravenous; Injections, Intravenous; Male; Models, Biological; Monoamine Oxidase Inhibitors; Niacinamide; Nicorandil; Rats; Rats, Sprague-Dawley | 1994 |
[Potassium channel openers. A new possible therapeutic principle in several diseases].
Topics: Antihypertensive Agents; Benzopyrans; Bronchodilator Agents; Cromakalim; Guanidines; Humans; Minoxidil; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Vasodilator Agents | 1994 |
[K-channel activators and cardioprotection].
Topics: Humans; Myocardial Ischemia; Niacinamide; Nicorandil; Potassium Channels | 1993 |
K(+)-channel openers protect the myocardium against ischemia-reperfusion injury.
Topics: Animals; In Vitro Techniques; Lipid Metabolism; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Niacinamide; Nicorandil; Picolines; Potassium Channels; Pyrans; Rats | 1994 |
The ATP-regulated potassium channel in ischemia-reperfusion injury.
Topics: Adenosine Triphosphate; Animals; Dogs; Glyburide; Ion Channel Gating; Myocardial Contraction; Myocardial Infarction; Myocardial Reperfusion Injury; Niacinamide; Nicorandil; Picolines; Potassium Channels; Pyrans; Tolbutamide | 1994 |
Evaluation of the efficacy of nicorandil in patients with ischemic heart disease by exercise Tl-201 myocardial SPECT.
Topics: Adult; Aged; Aged, 80 and over; Angina Pectoris; Angioplasty, Balloon, Coronary; Antihypertensive Agents; Coronary Angiography; Coronary Artery Bypass; Exercise Test; Female; Humans; Male; Middle Aged; Myocardial Infarction; Myocardial Ischemia; Niacinamide; Nicorandil; Thallium Radioisotopes; Tomography, Emission-Computed, Single-Photon; Vasodilator Agents | 1994 |
Mechanisms of vasodilation of cerebral vessels induced by the potassium channel opener nicorandil in canine in vivo experiments.
Topics: Administration, Topical; Animals; Arterioles; Benzopyrans; Cromakalim; Dimethyl Sulfoxide; Dogs; Glyburide; Methylene Blue; Microcirculation; Niacinamide; Nicorandil; Nitroglycerin; Pia Mater; Pyrroles; Vasodilation; Vasodilator Agents; Venules | 1994 |
Effect of acute and chronic immobilization stress on plasma levels of nicorandil administered orally to rats.
Topics: Acute Disease; Administration, Oral; Animals; Chronic Disease; Intestinal Absorption; Male; Niacinamide; Nicorandil; Rats; Rats, Wistar; Stress, Psychological | 1994 |
The effect of Nicorandil on chronic cerebral vasospasm.
Topics: Animals; Basilar Artery; Chronic Disease; Dogs; Female; Ischemic Attack, Transient; Male; Niacinamide; Nicorandil; Protein Kinase C; Subarachnoid Hemorrhage; Vascular Resistance; Vasodilator Agents | 1994 |
Prejunctional effects of cromakalim, nicorandil and pinacidil on noradrenergic transmission in rat isolated mesenteric artery.
Topics: Animals; Benzopyrans; Calcium; Cromakalim; Desipramine; Electric Stimulation; Extracellular Space; Female; Guanidines; In Vitro Techniques; Male; Mesenteric Arteries; Neuromuscular Junction; Niacinamide; Nicorandil; Norepinephrine; Pargyline; Phentolamine; Pinacidil; Pyrroles; Rats; Rats, Sprague-Dawley; Sympathetic Nervous System; Synaptic Transmission; Vasodilator Agents | 1994 |
[Cytoprotective effects of nicorandil on immature myocytes under hypothermic conditions].
Topics: Animals; Cells, Cultured; Cryopreservation; Culture Media; Myocardium; Niacinamide; Nicorandil; Rats | 1994 |
Possible presence of the ATP-sensitive K+ channel in isolated spinal dorsal horn neurons of the rat.
Topics: Adenosine Triphosphate; Animals; Cell Separation; Electric Stimulation; Electrophysiology; Glyburide; Minoxidil; Neurons; Niacinamide; Nicorandil; Potassium Channels; Rats; Rats, Sprague-Dawley; Spinal Cord | 1994 |
Pretreatment with the adenosine triphosphate-sensitive potassium channel opener nicorandil and improved myocardial protection during high-potassium cardioplegic hypoxia.
Topics: Action Potentials; Animals; Cardioplegic Solutions; Female; Glyburide; Guinea Pigs; Heart Arrest, Induced; Hypothermia, Induced; In Vitro Techniques; Myocardial Contraction; Niacinamide; Nicorandil; Papillary Muscles; Potassium; Potassium Channels; Time Factors; Vasodilator Agents | 1994 |
In vitro protective effects of nicorandil on hypothermic injury to immature cardiac myocytes: comparison with nitroglycerin.
Topics: Animals; Cell Survival; Cells, Cultured; Creatine Kinase; Heart; Hypothermia; L-Lactate Dehydrogenase; Male; Myocardial Contraction; Myocardium; Niacinamide; Nicorandil; Nitroglycerin; Organ Preservation; Rats; Rats, Wistar; Vasodilator Agents | 1994 |
Mechanism of the vasodilatory action of nicorandil on coronary circulation in dogs.
Topics: Animals; Benzopyrans; Coronary Circulation; Coronary Vessels; Cromakalim; Dogs; Dose-Response Relationship, Drug; Female; Glyburide; Hemodynamics; Injections, Intravenous; Male; Niacinamide; Nicorandil; Nitroglycerin; Potassium Channels; Pyrroles; Vasodilator Agents | 1994 |
Dissimilarity in the mechanisms of action of KRN2391, nicorandil and cromakalim in canine renal artery.
Topics: Animals; Benzopyrans; Cromakalim; Dogs; Female; Glyburide; In Vitro Techniques; Male; Methylene Blue; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitrates; Potassium Channels; Potassium Chloride; Pyridines; Pyrroles; Renal Artery; Vasodilator Agents | 1993 |
Evolving Issues in the Treatment of Ischaemic Heart Disease: The Potassium Channel Openers. Symposium proceedings. Barcelona, Spain, 2 September 1992.
Topics: Animals; Anti-Arrhythmia Agents; Humans; Myocardial Ischemia; Niacinamide; Nicorandil; Potassium Channels | 1993 |
Mechanism of action of KRN2391 in canine coronary vascular bed.
Topics: Animals; Antihypertensive Agents; Arteries; Benzopyrans; Coronary Circulation; Coronary Vessels; Cromakalim; Dogs; Drug Interactions; Female; Glyburide; In Vitro Techniques; Male; Methylene Blue; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Pyridines; Pyrroles; Vasodilator Agents | 1993 |
ATP sensitive potassium channel openers are of potential benefit in ischaemic heart disease.
Topics: Benzopyrans; Cromakalim; Dihydropyridines; Guanidines; Humans; Myocardial Ischemia; Myocardium; Niacinamide; Nicorandil; Picolines; Pinacidil; Potassium Channels; Pyrans; Pyrroles; Sodium-Potassium-Exchanging ATPase; Vasodilator Agents | 1994 |
Prevention of some hypothermia induced electromechanical changes by calcium channel blockade.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Calcium; Calcium Channel Blockers; Cold Temperature; Guinea Pigs; Heart; Niacinamide; Nicorandil; Nisoldipine; Tetrodotoxin; Time Factors; Vasodilator Agents | 1994 |
Effects of nicorandil on cytosolic calcium concentrations and on tension development in the rabbit femoral artery.
Topics: Animals; Benzopyrans; Calcium; Cromakalim; Cyclic GMP; Femoral Artery; Glyburide; In Vitro Techniques; Male; Niacinamide; Nicorandil; Nitroglycerin; Norepinephrine; Potassium; Potassium Channels; Pyrroles; Rabbits; Vasodilation; Vasodilator Agents | 1994 |
Effects of nicorandil on human isolated corpus cavernosum and cavernous artery.
Topics: Adult; Aged; Benzopyrans; Cromakalim; Humans; In Vitro Techniques; Male; Middle Aged; Molsidomine; Niacinamide; Nicorandil; Penis; Potassium Channels; Pyrroles; Vasodilator Agents | 1994 |
Effects of K-channel openers on the contractility and electrical activity of antral circular muscle in guinea-pig stomach.
Topics: Action Potentials; Animals; Benzopyrans; Cromakalim; Glyburide; Guinea Pigs; In Vitro Techniques; Ion Channel Gating; Muscle Contraction; Muscle, Smooth; Niacinamide; Nicorandil; Potassium Channels; Pyrroles; Stomach | 1993 |
Regulation of ATP-sensitive K+ channels by ATP and nucleotide diphosphate in rabbit portal vein.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Egtazic Acid; Guanidines; In Vitro Techniques; Ion Channel Gating; Magnesium; Male; Membrane Potentials; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Pinacidil; Portal Vein; Potassium Channels; Probability; Pyrroles; Rabbits; Ribonucleotides; Time Factors; Vasodilator Agents | 1994 |
Effect of nicorandil on post-ischaemic contractile dysfunction in the heart: roles of its ATP-sensitive K+ channel opening property and nitrate property.
Topics: Adenosine Triphosphate; Animals; Glyburide; Hemodynamics; Infusions, Intravenous; Ion Channel Gating; Male; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardial Stunning; Niacinamide; Nicorandil; Nitrates; Nitroglycerin; Potassium Channels; Premedication; Rabbits; Vasodilator Agents | 1993 |
Nicorandil as a nitrate, and cromakalim as a potassium channel opener, dilate isolated porcine large coronary arteries in an agonist-nonselective manner.
Topics: Animals; Benzopyrans; Coronary Vessels; Cromakalim; Glyburide; In Vitro Techniques; Niacinamide; Nicorandil; Nitrates; Potassium Channels; Pyrroles; Swine; Vasodilator Agents | 1993 |
Hyperpolarization induced by K+ channel openers inhibits Ca2+ influx and Ca2+ release in coronary artery.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Arteries; Calcium; Coronary Vessels; Dogs; Female; Fluorescence; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Pyridines; Swine; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents | 1993 |
Activation and reactivation of the ATP-sensitive K+ channel of the heart can be modified by drugs.
Topics: Adenosine Triphosphate; Animals; Electrophysiology; Guanidines; Guinea Pigs; Heart Ventricles; In Vitro Techniques; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Trypsin; Vasodilator Agents | 1993 |
High-performance liquid chromatographic method for stability and pharmacokinetic studies of nicorandil.
Topics: Animals; Biotransformation; Chromatography, High Pressure Liquid; Half-Life; Hydrogen-Ion Concentration; Indicators and Reagents; Models, Biological; Niacinamide; Nicorandil; Rats; Spectrophotometry, Ultraviolet; Vasodilator Agents | 1993 |
Effect of KRN2391, a novel vasodilator, on various experimental anginal models in rats.
Topics: Angina Pectoris; Animals; Disease Models, Animal; Electrocardiography; Injections, Intravenous; Isoproterenol; Male; Methacholine Chloride; Niacinamide; Nicorandil; Nifedipine; Pyridines; Rats; Rats, Wistar; Vasodilator Agents | 1993 |
Prevention of postischemic reperfusion injury: the improvement of myocardial tissue blood flow after ischemia by terminal nicorandil-Mg cardioplegia.
Topics: Animals; Blood Flow Velocity; Carbon Dioxide; Cardioplegic Solutions; Coronary Vessels; Dogs; Glucose; Magnesium; Myocardial Ischemia; Myocardial Reperfusion Injury; Niacinamide; Nicorandil; Oxygen Consumption; Partial Pressure; Vasodilator Agents | 1993 |
Mechanism of action of KRN2391, a novel vasodilator, in canine mesenteric artery.
Topics: Animals; Arterioles; Benzopyrans; Cromakalim; Dogs; Female; Glyburide; In Vitro Techniques; Male; Mesenteric Arteries; Methylene Blue; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Pyridines; Pyrroles; Splanchnic Circulation; Vascular Resistance; Vasodilator Agents | 1993 |
[Protective effects of nicorandil on action potentials in anoxia and reoxygenated ventricular myocardium of guinea pig].
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cell Hypoxia; Female; Guinea Pigs; In Vitro Techniques; Male; Myocardial Reperfusion; Myocardium; Niacinamide; Nicorandil; Ventricular Function | 1993 |
Vasorelaxant mechanism of KRN2391 and nicorandil in porcine coronary arteries of different sizes.
Topics: Animals; Benzopyrans; Coronary Vessels; Cromakalim; Glyburide; In Vitro Techniques; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitroglycerin; Oxyhemoglobins; Potassium Channels; Pyridines; Pyrroles; Swine; Vasodilator Agents | 1993 |
Pharmacological properties of ATP-sensitive K+ channels in mammalian skeletal muscle cells.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Electrophysiology; Glyburide; Guanidines; In Vitro Techniques; Mice; Muscles; Niacinamide; Nicorandil; Organic Chemicals; Pinacidil; Potassium Channels; Pyrroles; Vasodilator Agents | 1993 |
Comparative electrophysiological and mechanical actions of ATP-sensitive potassium channel openers in canine Purkinje fibers.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Dogs; Electrophysiology; Glyburide; Guanidines; In Vitro Techniques; Myocardial Contraction; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Purkinje Fibers; Pyrroles; Tetraethylammonium Compounds; Vasodilator Agents | 1993 |
Anti-ischaemic actions of potassium channel openers in experimental myocardial ischaemia/reperfusion injury in dogs.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Coronary Circulation; Dihydropyridines; Dogs; Female; Male; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Niacinamide; Nicorandil; Picolines; Potassium; Potassium Channels; Pyrans; Vasodilator Agents | 1993 |
Safety profile of an anti-anginal agent with potassium channel opening activity: an overview.
Topics: Adult; Aged; Aged, 80 and over; Angina Pectoris; Coronary Circulation; Drug Monitoring; Electrocardiography; Female; Hemodynamics; Humans; Male; Middle Aged; Myocardial Infarction; Niacinamide; Nicorandil; Potassium Channels; Vasodilator Agents | 1993 |
Sensitive method for determination of nicorandil in human plasma by reversed-phase high-performance liquid chromatography with ultraviolet detection.
Topics: Anti-Arrhythmia Agents; Chromatography, High Pressure Liquid; Humans; Molecular Structure; Niacinamide; Nicorandil; Reproducibility of Results; Spectrophotometry, Ultraviolet; Vasodilator Agents | 1993 |
Modification by cGMP of glibenclamide-sensitive K+ currents in Xenopus oocytes.
Topics: Animals; Benzopyrans; Cromakalim; Cyclic GMP; Female; Glyburide; In Vitro Techniques; Membrane Potentials; Methylene Blue; Niacinamide; Nicorandil; Nitroprusside; Oocytes; Potassium Channels; Pyridines; Pyrroles; Xenopus laevis | 1993 |
Effects of nicorandil on cell proliferation and cholesteryl ester accumulation in arterial smooth muscle cells in culture.
Topics: Animals; Aorta, Thoracic; Calcium Channels; Cell Division; Cells, Cultured; Cholesterol; Cholesterol Esters; Diltiazem; DNA; Male; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Rats; Rats, Wistar; Vasodilator Agents; Verapamil | 1993 |
Protection by nicorandil against the dysfunction of the central vagal baroreflex system following transient global cerebral ischaemia in dogs.
Topics: Animals; Aorta, Thoracic; Blood Pressure; Cerebrovascular Circulation; Dogs; Female; Heart Rate; Ischemic Attack, Transient; Male; Niacinamide; Nicardipine; Nicorandil; Nitroglycerin; Pressoreceptors; Reflex; Stereotaxic Techniques; Vagus Nerve; Vasodilator Agents | 1993 |
K+ channel openers prevent global ischemia-induced expression of c-fos, c-jun, heat shock protein, and amyloid beta-protein precursor genes and neuronal death in rat hippocampus.
Topics: Alternative Splicing; Amyloid beta-Protein Precursor; Animals; Base Sequence; Benzopyrans; Brain Ischemia; Cell Death; Cromakalim; Gene Expression Regulation; Guanidines; Heat-Shock Proteins; Hippocampus; In Situ Hybridization; Male; Molecular Sequence Data; Neurons; Niacinamide; Nicorandil; Oligonucleotide Probes; Pinacidil; Potassium Channels; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Pyrroles; Rats; Rats, Wistar; RNA, Messenger | 1993 |
Effects of nitric oxide-containing compounds on increases in cytosolic ionized Ca2+ and on aggregation of human platelets.
Topics: Calcium; Cytosol; Female; Humans; Isosorbide Dinitrate; Kinetics; Male; Niacinamide; Nicorandil; Nitric Oxide; Platelet Aggregation; Sydnones | 1993 |
Contribution of potassium accumulation in narrow extracellular spaces to the genesis of nicorandil-induced large inward tail current in guinea-pig ventricular cells.
Topics: Adenosine Triphosphate; Animals; Atrial Function; Calcium; Guinea Pigs; Heart Atria; Heart Ventricles; Membrane Potentials; Niacinamide; Nicorandil; Potassium; Ventricular Function | 1993 |
Activation by KRN2391 and nicorandil of glibenclamide-sensitive K+ channels in Xenopus oocytes.
Topics: Animals; Benzopyrans; Cromakalim; Electrophysiology; Epinephrine; Female; Glyburide; Niacinamide; Nicorandil; Oocytes; Phentolamine; Potassium Channels; Pyridines; Pyrroles; Trifluoperazine; Vasodilator Agents; Xenopus laevis | 1993 |
Relationship of severity of myocardial stunning to ATP dependent potassium channel modulation.
Topics: Adenosine Triphosphate; Animals; Coronary Circulation; Dogs; Glyburide; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion Injury; Niacinamide; Nicorandil; Potassium Channels; Vasodilator Agents | 1993 |
Study of the efficacy of nicorandil in patients with ischaemic heart disease using Exercise-T1-201 myocardial tomography.
Topics: Adult; Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Coronary Artery Bypass; Coronary Circulation; Exercise Test; Female; Humans; Male; Middle Aged; Myocardial Infarction; Myocardial Ischemia; Niacinamide; Nicorandil; Thallium Radioisotopes; Tomography, Emission-Computed, Single-Photon; Vasodilator Agents | 1993 |
Activation of ATP-dependent K+ channels enhances myocardial protection due to cold high potassium cardioplegia: a force-frequency relationship study.
Topics: Animals; Cold Temperature; Glyburide; Guinea Pigs; Heart; Heart Arrest, Induced; Ion Channel Gating; Muscle Contraction; Myocardium; Niacinamide; Nicorandil; Nitroglycerin; Potassium; Potassium Channels; Vasodilator Agents | 1995 |
Preconditioning with potassium channel openers. A new concept for enhancing cardioplegic protection?
Topics: Animals; Coronary Circulation; Glyburide; Heart Arrest, Induced; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Niacinamide; Nicorandil; Potassium Channels; Rats; Rats, Wistar; Ventricular Function, Left | 1995 |
Effects of nicorandil on the recovery of reflex potentials after spinal cord ischaemia in cats.
Topics: Animals; Blood Pressure; Cats; Female; Ischemia; Male; Niacinamide; Nicorandil; Nitroprusside; Reflex; Reperfusion; Spinal Cord Injuries; Time Factors; Vasodilator Agents | 1995 |
Vasodilatory effect of nicorandil on coronary arterial microvessels: its dependency on vessel size and the involvement of the ATP-sensitive potassium channels.
Topics: Adenosine Triphosphate; Analysis of Variance; Animals; Blood Glucose; Coronary Circulation; Coronary Vessels; Dogs; Dose-Response Relationship, Drug; Female; Glyburide; Hemodynamics; Hydrogen-Ion Concentration; Hypoglycemic Agents; Infusions, Intra-Arterial; Male; Niacinamide; Nicorandil; Potassium Channels; Vasodilator Agents | 1995 |
[Effects of nicorandil, a potassium agonist, on the human umbilical artery. Role of the vascular endothelium].
Topics: Antihypertensive Agents; Drug Interactions; Endothelium, Vascular; Humans; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Potassium Channels; Umbilical Arteries; Vasodilator Agents | 1995 |
Limitation of myocardial infarct size by nicorandil after sustained ischemia in pigs.
Topics: Animals; Blood Pressure; Cardiac Output; Female; Glutathione; Heart Rate; Isosorbide Dinitrate; Male; Malondialdehyde; Myocardial Infarction; Myocardial Ischemia; Myocardium; Niacinamide; Nicorandil; Peroxidase; Potassium Channels; Pulmonary Wedge Pressure; Swine; Vascular Resistance; Vasodilator Agents; Ventricular Function, Left | 1995 |
The role of ATP-sensitive potassium channels in striatal dopamine release: an in vivo microdialysis study.
Topics: Adenosine Triphosphate; Animals; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Male; Microdialysis; Niacinamide; Nicorandil; Potassium Channels; Rats; Rats, Wistar; Vasodilator Agents | 1995 |
Effects of cromakalim and nicorandil on intraocular pressure after topical administration in rabbit eyes.
Topics: Administration, Topical; Animals; Antihypertensive Agents; Benzopyrans; Blood Flow Velocity; Chymotrypsin; Cromakalim; Eye; Female; Intraocular Pressure; Male; Niacinamide; Nicorandil; Ocular Hypertension; Ophthalmic Solutions; Potassium Channels; Pyrroles; Rabbits | 1995 |
Nicorandil augments regional ischemia-induced monophasic action potential shortening and potassium accumulation without serious proarrhythmia.
Topics: Action Potentials; Animals; Coronary Circulation; Dogs; Myocardial Ischemia; Niacinamide; Nicorandil; Potassium; Potassium Channels; Vasodilator Agents; Ventricular Fibrillation | 1995 |
Cardiovascular interactions characterizing the vasodilator components of nicorandil in conscious dogs.
Topics: Animals; Blood Pressure; Cyclic GMP; Dogs; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Heart Rate; Male; Niacinamide; Nicorandil; Nitroglycerin; Potassium Channels; Vasodilator Agents | 1995 |
The HTK solution with nicorandil can improve cardiac function after simple cold storage.
Topics: Adenosine; Allopurinol; Animals; Biomarkers; Blood Pressure; Cardiac Output; Cardioplegic Solutions; Cold Temperature; Coronary Circulation; Glucose; Glutathione; Heart; Heart Rate; Hemodynamics; Insulin; Male; Mannitol; Niacinamide; Nicorandil; Organ Preservation; Organ Preservation Solutions; Potassium Chloride; Procaine; Raffinose; Rats; Rats, Wistar; Troponin; Troponin T; Vasodilator Agents | 1996 |
Comparison of the effects of nicorandil, pinacidil and nitroglycerin on hypoxic and hypercapnic pulmonary vasoconstriction in the isolated perfused lung of rat.
Topics: Acidosis; Animals; Guanidines; Hypercapnia; Hypoxia; In Vitro Techniques; Lung; Male; Niacinamide; Nicorandil; Nitric Oxide; Nitroglycerin; Pinacidil; Potassium Channel Blockers; Rats; Rats, Wistar; Vasoconstriction; Vasodilator Agents | 1996 |
Is potassium channel opening an effective form of preconditioning before cardioplegia?
Topics: Analysis of Variance; Animals; Blood Pressure; Cardiac Volume; Cardioplegic Solutions; Coronary Circulation; Heart Arrest, Induced; Hyperthermia, Induced; Ion Channel Gating; Male; Monoamine Oxidase Inhibitors; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion; Niacinamide; Nicorandil; Potassium Channels; Potassium Chloride; Preoperative Care; Rats; Rats, Wistar; Ventricular Function, Left | 1996 |
Endothelin-1 partially inhibits ATP-sensitive K+ current in guinea pig ventricular cells.
Topics: Action Potentials; Adenosine Triphosphate; Alkaloids; Animals; Azepines; Benzopyrans; Cromakalim; Endothelin Receptor Antagonists; Endothelins; Female; Glyburide; Guinea Pigs; Heart; Heart Ventricles; Hypoglycemic Agents; Male; Niacinamide; Nicorandil; Oligopeptides; Papillary Muscles; Potassium Channels; Protein Kinase C; Pyrroles; Staurosporine; Sulfonamides; Vasodilator Agents | 1996 |
Cardioprotective effect of nicorandil in histidine-tryptophan-ketoglurate solution during the cold storage of isolated hearts.
Topics: Adenosine; Allopurinol; Animals; Cardioplegic Solutions; Cold Temperature; Cyclic GMP; Glucose; Glutathione; Heart; Insulin; Male; Mannitol; Niacinamide; Nicorandil; Organ Preservation; Organ Preservation Solutions; Potassium Chloride; Procaine; Raffinose; Rats; Rats, Wistar; Vasodilator Agents | 1996 |
[Effects of nicorandil on spontaneous beating and action potentials of cultured myocardial cells of neonatal rats].
Topics: Action Potentials; Animals; Animals, Newborn; Anti-Arrhythmia Agents; Cells, Cultured; Heart; Myocardium; Niacinamide; Nicorandil; Rats; Rats, Wistar | 1995 |
Three distinct components of the negative inotropic action of lidocaine in dog Purkinje fiber.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Dogs; Electrophysiology; Female; Lidocaine; Male; Myocardial Contraction; Niacinamide; Nicorandil; Purkinje Fibers; Stimulation, Chemical | 1996 |
Different responses of epicardium and endocardium to KATP channel modulators during regional ischemia.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Decanoic Acids; Dogs; Endocardium; Hydroxy Acids; Myocardial Ischemia; Niacinamide; Nicorandil; Osmolar Concentration; Pericardium; Potassium; Potassium Channel Blockers; Potassium Channels; Reaction Time | 1996 |
Prevention of reoxygenation-induced arrhythmias in guinea pig papillary muscles.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium; Gallopamil; Guinea Pigs; In Vitro Techniques; Myocardial Reperfusion Injury; Niacinamide; Nicorandil; Papillary Muscles; Tetrodotoxin | 1996 |
KATP channel activation mediates nicorandil-induced relaxation of nitrate-tolerant coronary arteries.
Topics: Animals; Coronary Vessels; Dose-Response Relationship, Drug; Drug Tolerance; Glyburide; In Vitro Techniques; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitroglycerin; Potassium Channels; Swine; Vasodilator Agents | 1996 |
Infarct size-reducing effect of nicorandil is mediated by the KATP channel but not by its nitrate-like properties in dogs.
Topics: Adenosine; Animals; Dogs; Female; Glyburide; Ion Channel Gating; Male; Methylene Blue; Myocardial Infarction; Myocardial Reperfusion; Myocardium; Niacinamide; Nicorandil; Nitric Oxide; Nitroglycerin; Potassium Channels; Vasodilator Agents | 1996 |
Potassium channel openers prevent potassium-induced calcium loading of cardiac cells: possible implications in cardioplegia.
Topics: Adenosine Triphosphate; Aniline Compounds; Animals; Calcium; Calcium Channel Blockers; Cardioplegic Solutions; Cells, Cultured; Fluorescent Dyes; Glyburide; Guinea Pigs; Heart Arrest, Induced; Heart Ventricles; Hypertonic Solutions; Image Processing, Computer-Assisted; Ion Channel Gating; Microscopy, Confocal; Myocardium; Niacinamide; Nicorandil; Picolines; Potassium; Potassium Channel Blockers; Potassium Channels; Pyrans; Ventricular Dysfunction; Xanthenes | 1996 |
Nicorandil suppressed ventricular arrhythmias in a canine model of myocardial ischaemia.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Pressure; Coronary Circulation; Dogs; Electrocardiography; Female; Heart Rate; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Niacinamide; Nicorandil; Nitric Oxide; Vascular Resistance; Vasodilator Agents | 1996 |
Effects of glibenclamide and nicorandil in post-ischaemic contractile dysfunction of perfused hearts in normotensive and spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Cardiac Volume; Creatine Kinase; Glyburide; Heart Rate; Hemodynamics; Hypertension; In Vitro Techniques; Male; Myocardial Contraction; Myocardial Reperfusion Injury; Niacinamide; Nicorandil; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Time Factors | 1996 |
Effect of the new nitrate ester ITF 296 on coronary and systemic hemodynamics in the conscious dog: comparison with nitroglycerin and nicorandil.
Topics: Animals; Benzoxazines; Coronary Circulation; Coronary Vessels; Dogs; Female; Hemodynamics; Injections, Intravenous; Male; Niacinamide; Nicorandil; Nitrates; Nitroglycerin; Oxazines; Vasodilator Agents | 1995 |
Mechanisms of action of various ATP-sensitive potassium channel openers.
Topics: Adenosine Triphosphate; Animals; Dogs; Ion Channel Gating; Myocardial Ischemia; Niacinamide; Nicorandil; Potassium Channels; Rats; Vasodilator Agents | 1996 |
Effect of nicorandil on abnormal coronary flow reserve assessed by exercise 201Tl scintigraphy in patients with angina pectoris and nearly normal coronary arteriograms.
Topics: Adult; Aged; Angina Pectoris; Coronary Angiography; Coronary Circulation; Exercise Test; Female; Heart; Humans; Male; Middle Aged; Niacinamide; Nicorandil; Radionuclide Imaging; Thallium Radioisotopes; Vasodilator Agents | 1995 |
ATP-sensitive K+ channel openers block sulpiride-induced dopamine release in the rat striatum.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Dopamine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Male; Microdialysis; Monoamine Oxidase Inhibitors; Neostriatum; Nerve Endings; Niacinamide; Nicorandil; Potassium Channels; Pyrroles; Rats; Rats, Wistar; Substantia Nigra; Sulpiride; Vasodilator Agents | 1996 |
Kinetics of bupivacaine after nicorandil treatment in mice.
Topics: Anesthetics, Local; Animals; Area Under Curve; Bupivacaine; Drug Interactions; Half-Life; Male; Metabolic Clearance Rate; Mice; Niacinamide; Nicorandil; Potassium Channels | 1996 |
Effect of the potassium-channel opener nicorandil as an adjunct to cardioplegia on myocardial preservation in isolated rabbit hearts.
Topics: Animals; Cardioplegic Solutions; Coronary Circulation; Dose-Response Relationship, Drug; Glucose; Heart Arrest, Induced; Heart Rate; Hemodynamics; In Vitro Techniques; Male; Mannitol; Mitochondria, Heart; Myocardial Reperfusion; Myocardium; Niacinamide; Nicorandil; Potassium Channels; Potassium Chloride; Procaine; Rabbits | 1996 |
Nicorandil, a potent adenosine triphosphate-sensitive potassium-channel opener, ameliorates lung allograft reperfusion injury.
Topics: Animals; Dogs; Hemodynamics; Lung; Lung Transplantation; Niacinamide; Nicorandil; Potassium Channels; Reperfusion Injury; Transplantation, Homologous | 1996 |
Role of activation of ectosolic 5'-nucleotidase in the cardioprotection mediated by opening of K+c channels.
Topics: 5'-Nucleotidase; Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Dogs; Enzyme Activation; Glyburide; Heart; Hemodynamics; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; Niacinamide; Nicorandil; Potassium Channels; Pyrroles; Recurrence | 1996 |
[Nicorandil, as ATP-sensitive K+ channel opener, potentiated morphine analgesia].
Topics: Adenosine Triphosphate; Analgesia; Analgesics, Opioid; Animals; Drug Synergism; Male; Morphine; Niacinamide; Nicorandil; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Sprague-Dawley | 1996 |
Effects of chronic oral administration of a high dose of nicorandil on in vitro contractility of rat arterial smooth muscle.
Topics: Administration, Oral; Animals; Aorta, Thoracic; Dose-Response Relationship, Drug; Drug Interactions; Male; Muscle Contraction; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Rats; Rats, Wistar; Vasodilator Agents | 1996 |
alpha 1-Adrenoceptor stimulation partially inhibits ATP-sensitive K+ current in guinea pig ventricular cells: attenuation of the action potential shortening induced by hypoxia and K+ channel openers.
Topics: Action Potentials; Adrenergic alpha-Agonists; Animals; Benzopyrans; Cells, Cultured; Cromakalim; Female; Guinea Pigs; Heart; Heart Ventricles; Hypoxia; Male; Methoxamine; Niacinamide; Nicorandil; Papillary Muscles; Patch-Clamp Techniques; Potassium Channels; Pyrroles; Ventricular Function | 1996 |
Inotropic and coronary vasodilatory actions of the K-adenosine triphosphate channel modulator nicorandil in human tissue.
Topics: Adenosine Triphosphate; Adult; Calcium; Cardiomyopathy, Dilated; Coronary Vessels; Female; Humans; In Vitro Techniques; Male; Middle Aged; Myocardial Contraction; Myocardium; Niacinamide; Nicorandil; Potassium Channels; Vascular Resistance; Vasodilator Agents | 1996 |
Analysis of relaxation and repolarization mechanisms of nicorandil in rat mesenteric artery.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Benzopyrans; Calcium Channel Blockers; Cromakalim; Electrophysiology; Glyburide; Hypoglycemic Agents; In Vitro Techniques; Male; Membrane Potentials; Mesenteric Arteries; Methylene Blue; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nifedipine; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Rats; Rats, Sprague-Dawley; Thromboxane A2; Vasoconstrictor Agents; Vasodilator Agents | 1996 |
Nicorandil activates glibenclamide-sensitive K+ channels in smooth muscle cells of pig proximal urethra.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Cyclic GMP; Female; Glyburide; Membrane Potentials; Muscle, Smooth; Niacinamide; Nicorandil; Potassium Channels; Pyrroles; Swine; Urethra | 1997 |
Fluorimetric determination of nicorandil in human plasma by a high-performance liquid chromatographic-postcolumn ultraviolet irradiation [corrected] system equipped with on-line back-pressure tubing.
Topics: Administration, Oral; Anti-Infective Agents, Local; Calibration; Chromatography, High Pressure Liquid; Drug Stability; Fluorometry; Humans; Hydrogen Peroxide; Male; Niacinamide; Nicorandil; Online Systems; Reproducibility of Results; Spectrophotometry, Ultraviolet; Vasodilator Agents | 1996 |
[Potassium channel activators: hemodynamic effects at the systemic and coronary level].
Topics: Animals; Coronary Circulation; Hemodynamics; Humans; Myocardial Ischemia; Niacinamide; Nicorandil; Potassium Channels; Vasodilator Agents | 1995 |
Comparison of proarrhythmogenic effects of two potassium channel openers, levcromakalim (BRL 38227) and nicorandil (RP 46417): a high-resolution mapping study on rabbit heart.
Topics: Animals; Arrhythmias, Cardiac; Benzopyrans; Bradycardia; Cromakalim; Dose-Response Relationship, Drug; Electrophysiology; Heart; In Vitro Techniques; Isosorbide Dinitrate; Niacinamide; Nicorandil; Potassium Channels; Pyrroles; Rabbits; Tachycardia; Vasodilator Agents; Ventricular Fibrillation | 1997 |
[Nicorandil, a potassium channel agonist].
Topics: Drug Interactions; Humans; Niacinamide; Nicorandil; Patient Selection; Vasodilator Agents | 1996 |
Effect of JTV-506, a novel vasodilator, on coronary blood flow in conscious dogs.
Topics: Administration, Oral; Animals; Benzopyrans; Blood Pressure; Chromans; Coronary Circulation; Cromakalim; Diltiazem; Dogs; Dose-Response Relationship, Drug; Female; Heart Rate; Injections, Intravenous; Male; Niacinamide; Nicorandil; Nitroglycerin; Pyrroles; Vasodilator Agents | 1997 |
[Successful treatment of intraoperative myocardial ischemia with nicorandil].
Topics: Aged; Aged, 80 and over; Anesthesia; Female; Humans; Injections, Intravenous; Intraoperative Complications; Male; Middle Aged; Myocardial Ischemia; Niacinamide; Nicorandil; Vasodilator Agents | 1997 |
Sulphonylurea receptor 2B and Kir6.1 form a sulphonylurea-sensitive but ATP-insensitive K+ channel.
Topics: Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Cloning, Molecular; Glyburide; Guanidines; Guanosine Diphosphate; Guanosine Triphosphate; Hypoglycemic Agents; KATP Channels; Macromolecular Substances; Magnesium; Mice; Molecular Sequence Data; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Patch-Clamp Techniques; Pinacidil; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Sulfonylurea Compounds; Sulfonylurea Receptors; Uridine Diphosphate; Vasodilator Agents | 1997 |
Sinus arrest and severe peripheral vasodilation following cardiopulmonary bypass in a patient taking nicorandil.
Topics: Aged; Coronary Artery Bypass; Heart Arrest; Humans; Male; Niacinamide; Nicorandil; Regional Blood Flow; Vasodilation; Vasodilator Agents | 1997 |
Pinacidil but not nicorandil opens ATP-sensitive K+ channels and protects against simulated ischemia in rabbit myocytes.
Topics: Adenosine Triphosphate; Animals; Cell Death; Disease Models, Animal; Electrophysiology; Female; Guanidines; Heart; Heart Ventricles; Male; Myocardial Ischemia; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Rabbits; Vasodilator Agents | 1997 |
[Giant buccal aphthosis caused by nicorandil].
Topics: Aged; Female; Humans; Male; Niacinamide; Nicorandil; Stomatitis, Aphthous; Vasodilator Agents | 1997 |
Disappearance of the 'no-reflow' phenomenon after adjunctive intracoronary administration of nicorandil in a patient with acute myocardial infarction.
Topics: Coronary Circulation; Coronary Vessels; Humans; Injections; Male; Middle Aged; Myocardial Infarction; Myocardial Reperfusion; Niacinamide; Nicorandil; Potassium Channels; Thrombolytic Therapy; Ultrasonography | 1997 |
Glibenclamide-induced blockade of ischemic preconditioning is time dependent in intact rat heart.
Topics: Animals; Antihypertensive Agents; Blood Glucose; Glyburide; Heart; Hemodynamics; Hypotension; Ischemic Preconditioning; Male; Myocardial Infarction; Niacinamide; Nicorandil; Rats; Rats, Wistar; Time Factors | 1997 |
Heterogeneity in the vasorelaxing effect of nicorandil on dog epicardial coronary arteries: comparison with other NO donors.
Topics: Animals; Atrial Natriuretic Factor; Benzopyrans; Coronary Vessels; Cromakalim; Cyclic GMP; Dogs; Female; Glyburide; In Vitro Techniques; Male; Methylene Blue; Molsidomine; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitric Oxide; Nitroglycerin; Nitroprusside; Oxyhemoglobins; Pyrroles; Vasodilator Agents | 1997 |
Influence of nitric oxide on luminol-enhanced chemiluminescence measured from porcine-stimulated leukocytes.
Topics: Animals; Arginine; Cell-Free System; Indicators and Reagents; Leukocytes; Luminescent Measurements; Luminol; NG-Nitroarginine Methyl Ester; Niacinamide; Nicorandil; Nitric Oxide; Swine; Sydnones; Tetradecanoylphorbol Acetate; Vasodilator Agents; Xanthine; Xanthine Oxidase; Xanthines | 1997 |
Beneficial effect of concomitant administration of isoflurane and nicorandil.
Topics: Adenosine Triphosphate; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Drug Therapy, Combination; Female; Fentanyl; Hemodynamics; Isoflurane; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Niacinamide; Nicorandil; Rabbits; Vasodilator Agents; Ventricular Function, Left | 1997 |
Effects of nitroprusside and nicorandil on catecholamine secretion and calcium mobilization in cultured bovine adrenal chromaffin cells.
Topics: Adrenal Medulla; Animals; Calcium; Catecholamines; Cattle; Cells, Cultured; Chromaffin Cells; Glyburide; Niacinamide; Nicorandil; Nifedipine; Nitroprusside; Vasodilator Agents | 1997 |
Ischaemic preconditioning may abolish the protection afforded by ATP-sensitive potassium channel openers in isolated human atrial muscle.
Topics: Adenosine Triphosphate; Adult; Aged; Angina Pectoris; Benzopyrans; Cromakalim; Female; Guanidines; Heart Atria; Humans; Ischemic Preconditioning, Myocardial; Male; Middle Aged; Myocardial Contraction; Niacinamide; Nicorandil; Potassium Channels; Vasodilator Agents | 1997 |
[Effects of nicorandil on regional cerebral oxygen saturation].
Topics: Adult; Aged; Anesthesia, General; Blood Volume; Brain; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Niacinamide; Nicorandil; Oxygen Consumption; Vasodilator Agents | 1997 |
Vasodilation profile of CD-832, a novel dihydropyridine derivative in rabbit aorta.
Topics: Adrenergic alpha-Agonists; Animals; Aorta, Thoracic; Calcium Channel Blockers; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Niacinamide; Nicorandil; Nifedipine; Nitrendipine; Nitroglycerin; Norepinephrine; Potassium Chloride; Rabbits; Vasodilation; Vasodilator Agents | 1997 |
Hyperpolarized cardioplegic arrest with nicorandil: advantages over other potassium channel openers.
Topics: Animals; Diastole; Female; Heart; Heart Arrest, Induced; Male; Niacinamide; Nicorandil; Potassium Channels; Rabbits; Systole | 1997 |
Synthesis and biological activity of novel 2-(alpha-alkoxyimino)benzylpyridine derivatives as K+ channel openers.
Topics: Administration, Oral; Animals; Aorta, Thoracic; Blood Pressure; Coronary Circulation; Cromakalim; Cyclic N-Oxides; Diltiazem; Dogs; Hypertension; Male; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitroglycerin; Potassium Channels; Pyridines; Rats; Rats, Inbred SHR; Rats, Wistar; Structure-Activity Relationship; Vasodilation; Vasodilator Agents | 1997 |
Ventricular fibrillation in preconditioned pig hearts: role of K+ATP channels.
Topics: Action Potentials; Animals; Blood Glucose; Blood Pressure; Glyburide; Heart; Heart Rate; Ischemic Preconditioning, Myocardial; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion; Niacinamide; Nicorandil; Potassium Channel Blockers; Potassium Channels; Swine; Time Factors; Vasodilator Agents; Ventricular Fibrillation | 1997 |
Myocardial protection afforded by nicorandil and ischaemic preconditioning in a rabbit infarct model in vivo.
Topics: Animals; Anti-Arrhythmia Agents; Disease Models, Animal; Hemodynamics; Ischemic Preconditioning, Myocardial; Male; Myocardial Infarction; Niacinamide; Nicorandil; Rabbits | 1998 |
Effect of JTV-506, a novel vasodilator, on experimental angina model in rats.
Topics: Administration, Oral; Angina Pectoris; Animals; Arginine Vasopressin; Blood Pressure; Chromans; Cromakalim; Dose-Response Relationship, Drug; Electrocardiography; Heart Rate; Injections, Intravenous; Male; Methacholine Chloride; Molecular Structure; Niacinamide; Nicorandil; Nifedipine; Rats; Rats, Sprague-Dawley; Vasoconstrictor Agents; Vasodilator Agents | 1998 |
An ATP-sensitive potassium (KATP) channel opener, nicorandil, lowers the threshold for ischemic preconditioning in barbital-anesthetized dogs.
Topics: Animals; Barbital; Dogs; Female; Heart; Ischemic Preconditioning, Myocardial; Male; Niacinamide; Nicorandil; Potassium Channels; Regional Blood Flow; Time Factors | 1997 |
Nicorandil reduces myocardial infarct size by opening the K(ATP) channel in rabbits.
Topics: Analysis of Variance; Animals; Blood Pressure; Dose-Response Relationship, Drug; Glyburide; Heart Rate; Linear Models; Male; Myocardial Infarction; Niacinamide; Nicorandil; Potassium Channel Blockers; Potassium Channels; Rabbits; Time Factors; Vasodilator Agents; Ventricular Fibrillation | 1997 |
The effects of nucleotides and potassium channel openers on the SUR2A/Kir6.2 complex K+ channel expressed in a mammalian cell line, HEK293T cells.
Topics: Adenosine Triphosphate; ATP-Binding Cassette Transporters; Cell Line; Diazoxide; Guanidines; Humans; Membrane Potentials; Niacinamide; Nicorandil; Patch-Clamp Techniques; Pinacidil; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Sulfonylurea Receptors; Uridine Diphosphate | 1998 |
ATP-sensitive potassium-channel-opening activity of CL-065, a 3-[(substituted-carbonyl)amino]-2H-1-benzopyran, in the rat.
Topics: Animals; Antihypertensive Agents; Aorta; Benzopyrans; Blood Pressure; Cromakalim; Female; Heart Rate; Male; Niacinamide; Nicorandil; Potassium Channels; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Vasodilation | 1998 |
Nicorandil improves ischemic changes in epicardial ECG during short-term coronary occlusion by opening ATP-sensitive potassium channels in pigs.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Coronary Circulation; Coronary Disease; Electrocardiography; Female; Hemodynamics; In Vitro Techniques; Male; Niacinamide; Nicorandil; Pericardium; Potassium Channels; Swine | 1997 |
Enhancement of the vasodepressor response to adenosine by nicorandil in rats: comparison with cromakalim.
Topics: Adenosine; Adenosine Triphosphate; Animals; Blood Pressure; Cromakalim; Drug Synergism; Glyburide; Heart Rate; Male; Niacinamide; Nicorandil; Potassium Channels; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 1998 |
Regional differences in the vasorelaxant effects of nicorandil and amlodipine on isolated porcine coronary arteries.
Topics: Amlodipine; Animals; Calcium; Calcium Channel Blockers; Coronary Vessels; Enzyme Activation; Extracellular Space; Guanylate Cyclase; In Vitro Techniques; Methylene Blue; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Pericardium; Potassium; Potassium Channels; Swine; Vasodilation; Vasodilator Agents | 1998 |
Differential effects of nicorandil on the vasodepressor responses to vasoactive polypeptides administered intravenously to rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Calcitonin Gene-Related Peptide; Drug Interactions; Heart Rate; Injections, Intravenous; Male; Niacinamide; Nicorandil; Potassium Channels; Rats; Rats, Sprague-Dawley; Substance P; Vasoactive Intestinal Peptide; Vasodilator Agents; Vasomotor System | 1998 |
Role of K+ channel opening and stimulation of cyclic GMP in the vasorelaxant effects of nicorandil in isolated piglet pulmonary and mesenteric arteries: relative efficacy and interactions between both pathways.
Topics: Animals; Cromakalim; Cyclic GMP; Enzyme Activation; Enzyme Inhibitors; Glyburide; Guanylate Cyclase; In Vitro Techniques; Male; Mesenteric Arteries; Niacinamide; Nicorandil; Nitroprusside; Potassium Channels; Pulmonary Artery; Swine; Vasodilator Agents; Verapamil | 1998 |
Differential role of epicardial and endocardial K(ATP) channels in potassium accumulation during regional ischemia induced by embolization of a coronary artery with latex.
Topics: Adenosine Triphosphate; Algorithms; Animals; Coronary Vessels; Dogs; Embolization, Therapeutic; Endocardium; Glyburide; Microelectrodes; Microspheres; Myocardial Ischemia; Niacinamide; Nicorandil; Pericardium; Potassium; Potassium Channel Blockers; Potassium Channels; Vasodilator Agents | 1998 |
Vascular levels and cGMP-increasing effects of nicorandil administered orally to rats.
Topics: Administration, Oral; Animals; Aorta, Thoracic; Cyclic GMP; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Potassium Channels; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 1998 |
Potentiating effect of nicorandil on the adenosine A2 receptor-mediated vasodepression in rats: potential role for KATP channels.
Topics: Adenosine; Animals; Antihypertensive Agents; Blood Pressure; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Heart Rate; Injections, Intravenous; Male; Niacinamide; Nicorandil; Potassium Channels; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Theobromine; Vasodilator Agents | 1998 |
Effects of the ATP-sensitive K channel opener nicorandil on the QT interval and the effective refractory period in patients with congenital long QT syndrome. Investigator Group for K-Channel Openers and Arrhythmias.
Topics: Administration, Oral; Adolescent; Adult; Aged; Anti-Arrhythmia Agents; Dose-Response Relationship, Drug; Electrocardiography; Electrocardiography, Ambulatory; Female; Humans; Infusions, Intravenous; Long QT Syndrome; Male; Middle Aged; Niacinamide; Nicorandil; Potassium Channels; Torsades de Pointes | 1998 |
Improvement of repolarization abnormalities by a K+ channel opener in the LQT1 form of congenital long-QT syndrome.
Topics: Adolescent; Adult; Anti-Arrhythmia Agents; Child; Electrophysiology; Epinephrine; Female; Humans; Long QT Syndrome; Male; Middle Aged; Niacinamide; Nicorandil; Potassium Channels | 1998 |
Chronic buccal ulceration induced by nicorandil.
Topics: Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Female; Humans; Male; Niacinamide; Nicorandil; Oral Ulcer | 1998 |
Frequency modulation of Ca2+ sparks is involved in regulation of arterial diameter by cyclic nucleotides.
Topics: Animals; Arteries; Calcium; Cerebral Arteries; Colforsin; Coronary Vessels; Electric Conductivity; In Vitro Techniques; Niacinamide; Nicorandil; Nitroprusside; Nucleotides, Cyclic; Potassium Channels; Rats; Vasodilator Agents; Vasomotor System | 1998 |
Nicorandil successfully abolished intraoperative torsade de pointes.
Topics: Aged; Electrocardiography; Female; Humans; Intraoperative Complications; Niacinamide; Nicorandil; Torsades de Pointes; Vasodilator Agents | 1998 |
Cardiovascular effects of concomitant administration of isoflurane and nicorandil in dogs.
Topics: Anesthetics, Inhalation; Animals; Blood Pressure; Cardiovascular System; Dogs; Dose-Response Relationship, Drug; Drug Interactions; Female; Heart Rate; Isoflurane; Male; Niacinamide; Nicorandil; Vasodilator Agents; Ventricular Function, Left | 1998 |
Giant oral aphthous ulcers induced by nicorandil.
Topics: Aged; Humans; Male; Niacinamide; Nicorandil; Stomatitis, Aphthous; Vasodilator Agents | 1998 |
Beneficial hemodynamic effects of nicorandil in a canine model of acute congestive heart failure: comparison with nitroglycerin and cromakalim.
Topics: Acute Disease; Animals; Blood Pressure; Coronary Circulation; Cromakalim; Disease Models, Animal; Dogs; Female; Heart; Heart Failure; Heart Rate; Male; Myocardial Contraction; Myocardium; Niacinamide; Nicorandil; Nitroglycerin; Saponins; Vasodilator Agents | 1998 |
Nicorandil affects diurnal rhythms of body temperature, heart rate and locomotor activity in rats.
Topics: Animals; Body Temperature; Circadian Rhythm; Heart Rate; Male; Motor Activity; Niacinamide; Nicorandil; Potassium Channels; Rats; Rats, Wistar; Telemetry | 1998 |
Enhancement of the vasorelaxant potency of nicorandil by metabolic inhibition and adenosine in the pig coronary artery.
Topics: 2-Chloroadenosine; Animals; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Coronary Vessels; Glucose; Glyburide; Hydrogen-Ion Concentration; Hypoglycemic Agents; In Vitro Techniques; Ionophores; Niacinamide; Nicorandil; Potassium Channels; Swine; Vasodilator Agents | 1998 |
Interrelationship of cardiovascular effects, plasma levels of nicorandil, and vascular cGMP formation in conscious rats.
Topics: Administration, Oral; Animals; Blood Pressure; Cyclic GMP; Glyburide; Hypoglycemic Agents; Male; Niacinamide; Nicorandil; Rats; Rats, Sprague-Dawley; Time Factors; Vasodilator Agents | 1998 |
Inhibition of the pacemaker current: a bradycardic therapy for off-pump coronary operations.
Topics: Adrenergic beta-Antagonists; Animals; Anti-Arrhythmia Agents; Benzazepines; Bradycardia; Cardiac Output; Cardiac Volume; Cardioplegic Solutions; Cardiopulmonary Bypass; Cardiotonic Agents; Coronary Artery Bypass; Coronary Circulation; Diastole; Heart Arrest, Induced; Heart Rate; Ivabradine; Myocardial Contraction; Niacinamide; Nicorandil; Potassium; Potassium Channels; Propanolamines; Rabbits; Sinoatrial Node; Stereoisomerism; Ventricular Function, Left | 1998 |
SUR2 subtype (A and B)-dependent differential activation of the cloned ATP-sensitive K+ channels by pinacidil and nicorandil.
Topics: Adenosine Triphosphate; ATP-Binding Cassette Transporters; Cell Line; Guanidines; Humans; Kidney; Muscle, Smooth, Vascular; Myocardium; Niacinamide; Nicorandil; Patch-Clamp Techniques; Pinacidil; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Sulfonylurea Compounds; Sulfonylurea Receptors; Vasodilator Agents | 1998 |
The effects of nicorandil on electrophysiological changes in acute myocardial ischemia and reperfusion.
Topics: Acute Disease; Animals; Anti-Arrhythmia Agents; Disease Models, Animal; Dogs; Drug Evaluation, Preclinical; Electrophysiology; Myocardial Ischemia; Myocardial Reperfusion Injury; Niacinamide; Nicorandil; Potassium Channels; Ventricular Fibrillation | 1998 |
Comparison of the potentiating effects of nicorandil and its denitrated metabolite (SG-86) on the adenosine-induced vasodepression in rats.
Topics: Adenosine; Animals; Dose-Response Relationship, Drug; Drug Synergism; Glyburide; Hypoglycemic Agents; Injections, Intravenous; Male; Niacinamide; Nicorandil; Rats; Rats, Sprague-Dawley; Vasoconstriction; Vasodilator Agents | 1998 |
Nicorandil, its denitrated metabolite, SG-86 and naturally occurring vasodilators synergistically interact on adenosine-induced vasodepression in rats: special reference to adrenomedullin.
Topics: Adenosine; Adrenomedullin; Animals; Blood Pressure; Blood Vessels; Calcitonin Gene-Related Peptide; Dose-Response Relationship, Drug; Drug Interactions; Drug Synergism; Glyburide; Heart Rate; Hypoglycemic Agents; Infusions, Intravenous; Injections, Intravenous; Male; Niacinamide; Nicorandil; Peptides; Rats; Rats, Sprague-Dawley; Vasoactive Intestinal Peptide; Vasodilator Agents | 1999 |
Nicorandil metabolism in rat myocardial mitochondria.
Topics: Animals; Anti-Arrhythmia Agents; Glutathione; In Vitro Techniques; Liver; Lung; Male; Microsomes; Mitochondria, Heart; Myocardium; NADP; Niacinamide; Nicorandil; Nitric Oxide; Rats; Rats, Sprague-Dawley; Subcellular Fractions | 2000 |
Nicorandil inhibits degranulation and TNF-alpha release from RBL-2H3 cells.
Topics: Animals; beta-N-Acetylhexosaminidases; Calcium; Cell Degranulation; Cell Line; Cytoplasmic Granules; Cytosol; Dinitrophenols; Enzyme Inhibitors; Glyburide; Guanylate Cyclase; Hemoglobins; Indicators and Reagents; Mast Cells; Niacinamide; Nicorandil; Nitric Oxide; Nitric Oxide Donors; Pinacidil; Potassium; Potassium Channel Blockers; Potassium Channels; Rats; Tumor Necrosis Factor-alpha | 2002 |
Nicorandil inhibits the release of TNFalpha from a lymphocyte cell line and peripheral blood lymphocytes.
Topics: B-Lymphocytes; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glyburide; Herpesvirus 4, Human; Humans; Immunoglobulin G; Leukocytes, Mononuclear; Niacinamide; Nicorandil; Nitric Oxide Synthase; Nitroprusside; omega-N-Methylarginine; Oxadiazoles; Pinacidil; Potassium Channels; Quinoxalines; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 2003 |
Nicorandil and ulcerations: a NAD/NADP and nicotinic acid-dependent side-effect?
Topics: Humans; NAD; NADP; Niacin; Niacinamide; Nicorandil; Ulcer; Vasodilator Agents | 2008 |
Effects of chronic treatment with a low dose of nicorandil on the function of the rat aorta during ageing.
Topics: Aging; Animals; Antihypertensive Agents; Aorta; Biomechanical Phenomena; Collagen; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Evaluation, Preclinical; Elastin; Female; Niacinamide; Nicorandil; Rats; Rats, Wistar; Time Factors; Vasodilation | 2009 |
Simultaneous quantitation of nicorandil and its denitrated metabolite in plasma by LC-MS/MS: application for a pharmacokinetic study.
Topics: Animals; Chromatography, Liquid; Female; Male; Niacinamide; Nicorandil; Procainamide; Rats; Rats, Wistar; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2011 |
[Nicorandil and ulceration: a physiopathological hypothesis].
Topics: Angina Pectoris; Drug Eruptions; Humans; NAD; NADP; Niacin; Niacinamide; Nicorandil; Skin; Skin Ulcer; Vasodilator Agents | 2012 |
Role of nicotinic acid and nicotinamide in nicorandil-induced ulcerations: from hypothesis to demonstration.
Topics: Aged, 80 and over; Female; Humans; Niacin; Niacinamide; Nicorandil; Skin Ulcer; Vasodilator Agents | 2015 |
Green hands: a rare manifestation of nicorandil-induced methaemoglobinemia.
Topics: Anti-Arrhythmia Agents; Hand; Humans; Methemoglobinemia; Niacinamide; Nicorandil; Vasodilator Agents | 2021 |