Compounds > niacinamide

niacinamide and n-cyclobutyl-6-((3-fluorophenyl)ethynyl)nicotinamide

niacinamide has been researched along with n-cyclobutyl-6-((3-fluorophenyl)ethynyl)nicotinamide in 11 studies

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's7 (63.64)24.3611
2020's4 (36.36)2.80

Authors

AuthorsStudies
Conn, PJ; Kiritoshi, T; Lindsley, CW; Neugebauer, V; Ren, W; Stauffer, SR; Sun, H1
Biagioni, F; Conn, PJ; D'Amore, V; Jones, CK; Lindsley, CW; Molinaro, G; Ngomba, RT; Nicoletti, F; Prete, A; Rodriguez, AL; Santolini, I; Stauffer, SR; van Luijtelaar, G; van Rijn, CM; Vinson, PN; Zhou, Y1
Battaglia, G; Biagioni, F; Bucci, D; Cannella, M; Fazio, F; Gradini, R; Lionetto, L; Mascio, G; Nicoletti, F; Notartomaso, S; Puliti, A; Scarselli, P; Signore, M; Simmaco, M; Weisz, F; Zappulla, C1
Ji, G; Neugebauer, V1
Bosco, P; Celli, R; Conn, PJ; D'Amore, V; De Fusco, A; Lionetto, L; Ngomba, RT; Nicoletti, F; Santolini, I; Simmaco, M; Stauffer, SR; van Luijtelaar, G; van Rijn, CM; Vieira, E1
Ansari, MS; Conn, PJ; Daniels, JS; Emmitte, KA; Felts, AS; Jones, CK; Kessler, RM; Lindsley, CW; Niswender, CM; Rook, JM; Stauffer, SR; Tantawy, MN1
Ade, KK; Bhagat, S; Calakos, N; Conn, PJ; Dzirasa, K; Guo, W; Hamann, HC; Huber, KM; Kumar, S; O'Hare, JK; Quian, A; Rodriguiz, RM; Wan, Y; Wetsel, WC1
Bhat, SA; Blanchard, AC; Faden, AI; Henry, RJ; Loane, DJ; Stoica, BA1
Bruno, V; Cannella, M; Celli, R; Ciruela, F; Di Menna, L; Mascio, G; Ngomba, RT; Nicoletti, F; Pittaluga, A; Santolini, I; van Luijtelaar, G; Vergassola, M; Wall, MJ1
Brown, J; Di Cicco, G; Fletcher, J; Grayson, B; Harte, M; Iacovelli, L; Neill, JC; Ngomba, RT; Rimmer, L; Wall, MJ1
Brown, J; Grayson, B; Harte, M; Neill, JC; Ngomba, RT; Wall, MJ1

Other Studies

11 other study(ies) available for niacinamide and n-cyclobutyl-6-((3-fluorophenyl)ethynyl)nicotinamide

ArticleYear
Modulation of pyramidal cell output in the medial prefrontal cortex by mGluR5 interacting with CB1.
    Neuropharmacology, 2013, Volume: 66

    Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glycine; Inhibitory Postsynaptic Potentials; Male; Morpholines; Neural Inhibition; Niacinamide; Phenylacetates; Prefrontal Cortex; Pyramidal Cells; Pyrazoles; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Synaptic Transmission; Thiazoles

2013
Potentiation of mGlu5 receptors with the novel enhancer, VU0360172, reduces spontaneous absence seizures in WAG/Rij rats.
    Neuropharmacology, 2013, Volume: 66

    Topics: Age Factors; Animals; Brain Waves; Cerebral Cortex; Disease Models, Animal; Electroencephalography; Epilepsy, Absence; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hydrolysis; Male; Motor Activity; Niacinamide; Phosphatidylinositol Phosphates; Pyridines; Rats; Rats, Inbred Strains; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Somatosensory Cortex; Thiazoles; Ventral Thalamic Nuclei

2013
Pharmacological enhancement of mGlu1 metabotropic glutamate receptors causes a prolonged symptomatic benefit in a mouse model of spinocerebellar ataxia type 1.
    Molecular brain, 2013, Nov-19, Volume: 6

    Topics: Amides; Animals; Cerebellum; Chromatography, High Pressure Liquid; Disease Models, Animal; Gene Expression Regulation; Mass Spectrometry; Mice; Motor Activity; Niacinamide; Purkinje Cells; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; RNA, Messenger; Spinocerebellar Ataxias

2013
CB1 augments mGluR5 function in medial prefrontal cortical neurons to inhibit amygdala hyperactivity in an arthritis pain model.
    The European journal of neuroscience, 2014, Volume: 39, Issue:3

    Topics: Amygdala; Animals; Arachidonic Acids; Arthritis, Experimental; Cannabinoid Receptor Agonists; Evoked Potentials; Male; Niacinamide; Pain; Prefrontal Cortex; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Metabotropic Glutamate 5

2014
Head-to head comparison of mGlu1 and mGlu5 receptor activation in chronic treatment of absence epilepsy in WAG/Rij rats.
    Neuropharmacology, 2014, Volume: 85

    Topics: Animals; Anticonvulsants; Blotting, Western; Cerebral Cortex; Disease Models, Animal; Drug Tolerance; Electrodes, Implanted; Electroencephalography; Epilepsy, Absence; Excitatory Amino Acid Agents; Male; Mice, Transgenic; Niacinamide; Rats; Rats, Inbred ACI; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Thalamus; Time Factors

2014
Relationship between in vivo receptor occupancy and efficacy of metabotropic glutamate receptor subtype 5 allosteric modulators with different in vitro binding profiles.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2015, Volume: 40, Issue:3

    Topics: Allosteric Regulation; Amphetamine; Animals; Benzamides; Calcium; Cerebellum; Corpus Striatum; Dose-Response Relationship, Drug; HEK293 Cells; Humans; Locomotion; Male; Maze Learning; Niacinamide; Piperidines; Positron-Emission Tomography; Radioligand Assay; Rats; Receptor, Metabotropic Glutamate 5; Structure-Activity Relationship; Thiazoles

2015
Increased Metabotropic Glutamate Receptor 5 Signaling Underlies Obsessive-Compulsive Disorder-like Behavioral and Striatal Circuit Abnormalities in Mice.
    Biological psychiatry, 2016, 10-01, Volume: 80, Issue:7

    Topics: Animals; Behavior, Animal; Corpus Striatum; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Grooming; Mice; Mice, Knockout; Mice, Transgenic; Nerve Tissue Proteins; Niacinamide; Obsessive-Compulsive Disorder; Pyridines; Receptor, Metabotropic Glutamate 5; Signal Transduction; Thiazoles

2016
Enhanced Akt/GSK-3β/CREB signaling mediates the anti-inflammatory actions of mGluR5 positive allosteric modulators in microglia and following traumatic brain injury in male mice.
    Journal of neurochemistry, 2021, Volume: 156, Issue:2

    Topics: Animals; Anti-Inflammatory Agents; Brain Injuries, Traumatic; Cyclic AMP Response Element-Binding Protein; Glycogen Synthase Kinase 3 beta; Male; Mice; Microglia; Neuroprotective Agents; Niacinamide; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Signal Transduction

2021
Pharmacological activation of mGlu5 receptors with the positive allosteric modulator VU0360172, modulates thalamic GABAergic transmission.
    Neuropharmacology, 2020, 11-01, Volume: 178

    Topics: Allosteric Regulation; Animals; Dose-Response Relationship, Drug; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Male; Niacinamide; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, GABA-A; Thalamus

2020
The comparative effects of mGlu5 receptor positive allosteric modulators VU0409551 and VU0360172 on cognitive deficits and signalling in the sub-chronic PCP rat model for schizophrenia.
    Neuropharmacology, 2022, 05-01, Volume: 208

    Topics: Allosteric Regulation; Animals; Cognition; Niacinamide; Oxazoles; Phencyclidine; Proto-Oncogene Proteins c-akt; Pyridines; Rats; Receptor, Metabotropic Glutamate 5; Schizophrenia

2022
Oscillatory Deficits in the Sub-Chronic PCP Rat Model for Schizophrenia Are Reversed by mGlu5 Receptor-Positive Allosteric Modulators VU0409551 and VU0360172.
    Cells, 2023, 03-16, Volume: 12, Issue:6

    Topics: Animals; Niacinamide; Prefrontal Cortex; Rats; Schizophrenia; Signal Transduction

2023