niacinamide has been researched along with leucine in 57 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 46 (80.70) | 18.7374 |
| 1990's | 3 (5.26) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 8 (14.04) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kajimoto, M; Nakagawa, I; Oguri, S; Sasaki, A; Sasaki, M | 1 |
| Carpenter, KJ; Manson, JA | 1 |
| Bender, DA | 2 |
| Abraham, MI; Campbell, PI; Kempson, SA | 1 |
| Al-Mahrouq, HA; Bacon, RA; Kempson, SA; Wu, KI | 1 |
| Carpenter, KJ; Cook, NE | 2 |
| Caplan, AI | 2 |
| Belavady, B; Khan, L; Rao, PU | 1 |
| Krishnaswamy, K; Reddy, MV; Srikantia, SG | 1 |
| den Dooren de Jong, LE | 1 |
| Herken, H; von Bruchhausen, F | 1 |
| Shmat'ko, TM | 1 |
| Ishizawa, J; Kuroki, T; Sato, H | 1 |
| Hirsch, GH; Hook, JB | 1 |
| Barrach, HJ; Köhler, E | 1 |
| Capuzzi, DM; Margolis, S | 1 |
| Albizati, LD; Hedrick, JL | 1 |
| Dean, PM; Matthews, EK | 1 |
| Krishnaswamy, K; Raghuram, TC | 1 |
| Prinsloo, JG | 1 |
| Belavady, B; Rao, PU | 1 |
| Eapen, J; Tarachand, U | 1 |
| Aĭzenberg NN+AIZENBERG, NN; Korabel'shchikova, NI; Lesik, OV | 1 |
| Ammon, HP; MacDonald, MJ; Patel, T; Steinke, J | 1 |
| Srinivasan, V; Wigfield, DC | 1 |
| Ames, E; Goor, RS; Pappenheimer, AM | 1 |
| Lojkin, ME | 1 |
| Mattioli, A; Montanaro, L; Sperti, S | 1 |
| Clerivet, A; Ragot, J | 1 |
| Parry, DG; Taylor, KW | 1 |
| Fujii, K; Imai, H; Nasu, S; Sakakibara, S; Ueda, I; Yamaguchi, K | 1 |
| Sano, K; Shin, M; Umezawa, C | 1 |
| Bender, DA; Magboul, BI | 1 |
| Kubota, H; Nomura, K; Sano, K; Shin, M; Umezawa, C; Yamada, O | 1 |
| Brown, RR; Harper, AE; Linkswiler, H; Patterson, JI | 1 |
| Imanaka, H; Iseki, M; Konomi, T; Miyoshi, T | 1 |
| Krishnaswamy, K; Narasinga Rao, BS | 1 |
| Kashiwada, J; Kato, Y; Kawaguchi, M; Seino, Y; Tamura, K; Tanigawa, K | 1 |
| Bolli, GB; Brunetti, P; Cruciani, G; De Feo, P; Lucidi, P; Monacchia, F; Reboldi, G; Volpi, E | 1 |
| BELAVADY, B; GOPALAN, C; SRIKANTIA, SG | 1 |
| MANDEL, P | 2 |
| TRUSWELL, AS | 1 |
| Gopalan, C; Narasingarao, BS; Raghuramulu, N | 1 |
| OHGURI, S | 1 |
| Plapp, BV; Ramaswamy, S | 1 |
| Bahnson, BJ; Dong, M; Klinman, JP; Meadows, CW; Nagel, ZD | 1 |
| Allegra, M; Bahadoran, P; Ballotti, R; Giacchero, D; Hofman, P; Lacour, JP; Le Duff, F; Long-Mira, E; Passeron, T | 1 |
| Fischer, JW; Freudenberger, T; Kretschmer, I; Nagy, N; Niedworok, C; Reis, H; Röck, K; Rübben, H; Szarvas, T; Vom Dorp, F | 1 |
| Kroemer, G; Madeo, F; Mariño, G; Pietrocola, F | 1 |
| Asaoka, T; Doki, Y; Eguchi, H; Gotoh, K; Kawamoto, K; Mori, M; Noda, T; Ogawa, H; Umeshita, K; Wada, H; Yamada, D; Yamashita, M | 1 |
| Djukovic, D; Gu, H; O'Keefe, GE; Parent, BA; Raftery, D; Seaton, M; Sood, RF | 1 |
| Ding, S; Gao, D; Gao, M; Liu, S; Lv, J; Niu, Z; Wang, X; Wang, Z | 1 |
57 other study(ies) available for niacinamide and leucine
| Article | Year |
|---|---|
Effects of excess intake of leucine and valine deficiency on tryptophan and niacin metabolites in humans.
Topics: Adult; Amino Acids; Dose-Response Relationship, Drug; Female; Humans; Hydroxyindoleacetic Acid; Leucine; Male; Middle Aged; Niacinamide; Nicotinic Acids; Nitrogen; Pyridones; Pyridoxine; Quinolinic Acids; Tryptophan; Valine | 1975 |
The effect of a high level of dietary leucine on the niacin status of dogs.
Topics: Amino Acids; Animals; Body Weight; Caseins; Dietary Proteins; Dogs; Female; Leucine; Male; Niacinamide; Nicotinic Acids; Species Specificity | 1978 |
Inhibition of tryptophan----niacin metabolism by dietary leucine and by leucine and 2-oxo-isocaproate in vitro.
Topics: Animals; Cells, Cultured; Depression, Chemical; Dietary Proteins; Keto Acids; Kynurenine; Leucine; Liver; NADP; Niacin; Niacinamide; Pellagra; Rats; Tryptophan; Xanthurenates | 1991 |
Effects of a dietary excess of leucine and of the addition of leucine and 2-oxo-isocaproate on the metabolism of tryptophan and niacin in isolated rat liver cells.
Topics: Animals; Caproates; In Vitro Techniques; Keto Acids; Kynurenine; Leucine; Liver; Male; NAD; Niacin; Niacinamide; Rats; Rats, Inbred Strains; Tryptophan; Xanthurenates | 1989 |
Increased cAMP in proximal tubules is acute effect of nicotinamide analogues.
Topics: Animals; Biological Transport; Cyclic AMP; In Vitro Techniques; Kidney Tubules, Proximal; Kinetics; Leucine; Male; Microvilli; Niacinamide; Phosphates; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Thymidine | 1989 |
Nicotinamide as a rapid-acting inhibitor of renal brush-border phosphate transport.
Topics: Animals; Biological Transport, Active; Cyclic AMP; Cycloheximide; Dactinomycin; Kidney Cortex; Leucine; Male; Microvilli; Niacinamide; Phosphates; Rats; Rats, Inbred Strains | 1988 |
Leucine excess and niacin status in rats.
Topics: Animals; Body Weight; Diet; Edible Grain; India; Leucine; Liver; Male; Niacin; Niacinamide; Nicotinamide Mononucleotide; Nutritional Status; Pellagra; Rats; Rats, Inbred Strains; Statistics as Topic; Tryptophan; Vitamin B 6 Deficiency | 1987 |
Is leucine excess a factor in pellagra?
Topics: Animals; Leucine; Niacin; Niacinamide; Pellagra; Rats; Tryptophan | 1987 |
Ethanol and leucine as possible stress factors in rats marginally deficient in niacin and vitamin B-6.
Topics: Analysis of Variance; Animals; Body Weight; Energy Intake; Ethanol; Leucine; Male; Niacin; Niacinamide; Pellagra; Pyridoxine; Random Allocation; Rats; Rats, Inbred Strains; Stress, Physiological; Vitamin B 6 Deficiency | 1988 |
Effects of a nicotinamide-sensitive teratogen 6-aminonicotinamide on chick limb cells in culture.
Topics: Abnormalities, Drug-Induced; Amines; Animals; Bone and Bones; Carbon Isotopes; Cartilage; Cells, Cultured; Chick Embryo; Culture Techniques; Ketones; Leucine; Mesoderm; Niacinamide; Proline; Pyridines; Staining and Labeling; Sulfates; Sulfur Isotopes; Thymidine; Tritium; Wings, Animal | 1972 |
Effects of leucine and isoleucine on nicotinamide nucleotides of erythrocytes.
Topics: Adult; Blood Glucose; Carbon Dioxide; Carbon Radioisotopes; Drug Synergism; Erythrocytes; Feces; Glycolysis; Humans; Isoleucine; Lactates; Leucine; Male; NAD; NADP; Niacinamide; Nicotinamide Mononucleotide; Oxidation-Reduction; Pyridines; Ribonucleotides; Time Factors | 1973 |
Electroencephalographic patterns in pellagra.
Topics: Adult; Electroencephalography; Humans; Leucine; Male; Mental Disorders; Niacinamide; Pellagra; Pyridines | 1968 |
Dark and light metabolism of amino acids in Chlorella vulgaris.
Topics: Amino Acids; Darkness; Eukaryota; Histidine; Leucine; Light; Niacinamide; Tryptophan | 1967 |
[Effect of 6-aminonicotinic acid amide on insulin dependant glucose uptake in epididymal fat tissue].
Topics: Adipose Tissue; Animals; Carbon Dioxide; Carbon Isotopes; Epididymis; Glucose; Insulin; Leucine; Lipid Metabolism; Male; Niacinamide; Phosphorylase Kinase; Proteins; Rats | 1966 |
[Change in the content of some free amino acids in albino rat liver under effect of nicotinamide].
Topics: Amidines; Amino Acids; Animals; Chromatography, Paper; Leucine; Liver; Lysine; Niacinamide; Rats; Stimulation, Chemical; Threonine; Valine | 1968 |
Studies on early events in in vitro carcinogenesis with 4-nitroquinoline 1-oxide. I. Effect on macromolecular synthesis and cell life cycle.
Topics: Animals; Carcinogens; Cricetinae; Culture Techniques; DNA; Embryo, Mammalian; Leucine; Macromolecular Substances; Mitosis; Niacinamide; Protein Biosynthesis; Quinolines; RNA; Thymidine; Time Factors; Tritium; Uridine | 1969 |
Stimulation of renal organic acid transport and protein synthesis by penicillin.
Topics: Aminohippuric Acids; Ammonium Chloride; Animals; Biological Transport, Active; Body Fluids; Body Weight; Carbon Isotopes; Cycloheximide; Female; Glutamine; In Vitro Techniques; Kidney; Lactation; Leucine; Niacinamide; Organ Size; Orotic Acid; Penicillins; Pregnancy; Protein Biosynthesis; Proteins; Rats; RNA | 1970 |
Biochemical studies of the embryotoxic action of 6-aminonicotinamide.
Topics: Abnormalities, Drug-Induced; Acetates; Aspartic Acid; Carbon Isotopes; DNA; Embryo, Mammalian; Embryo, Nonmammalian; Female; Glucose; Glycine; Leucine; Lipids; Niacinamide; Pentosephosphates; Pregnancy; Protein Biosynthesis | 1970 |
Metabolic studies in isolated rat liver cells. II. Biosynthesis of serum low density lipoproteins and its regulation.
Topics: Acetates; Animals; Antigens; Buffers; Carbon Isotopes; Carrier Proteins; Chlorides; Clofibrate; Depression, Chemical; Dietary Fats; Goats; Immune Sera; Immunodiffusion; Immunoelectrophoresis; Leucine; Lipids; Lipoproteins; Liver; Magnesium; Metabolism; Niacinamide; Phosphates; Precipitin Tests; Protein Biosynthesis; Puromycin; Rabbits; Rats; Stimulation, Chemical; Succinates; Time Factors; Triglycerides; Tromethamine; Ultracentrifugation | 1971 |
Active-site studies on rabbit liver nicotinamide deamidase.
Topics: Amidohydrolases; Animals; Benzoates; Benzyl Compounds; Binding Sites; Carbon Isotopes; Carboxypeptidases; Catalysis; Disulfides; Formates; Hydrogen-Ion Concentration; Isoflurophate; Kinetics; Leucine; Microsomes, Liver; Niacinamide; Nicotinic Acids; Nitro Compounds; Nitrophenols; Phosphorus Isotopes; Protein Binding; Rabbits; Sulfhydryl Compounds | 1972 |
The effects of the nicotinamide sensitive teratogen 3-acetylpyridine on chick limb mesodermal cells in culture: biochemical parameters.
Topics: Abnormalities, Drug-Induced; Animals; Carbon Isotopes; Cartilage; Cell Differentiation; Cells, Cultured; Chick Embryo; DNA; Glycosaminoglycans; Ketones; Leucine; Limb Deformities, Congenital; Mesoderm; Muscles; Niacinamide; Phenotype; Proline; Pyridines; RNA; Thymidine; Tritium; Uridine | 1972 |
The bioelectrical properties of pancreatic islet cells: effects of diabetogenic agents.
Topics: Action Potentials; Alloxan; Animals; Anti-Bacterial Agents; Diabetes Mellitus, Experimental; Female; Glucosamine; Glucose; Glutathione; Glyceraldehyde; Heptoses; In Vitro Techniques; Islets of Langerhans; Leucine; Male; Mice; Niacinamide; Nitroso Compounds; Tolbutamide; Urea | 1972 |
Effect of leucine and isoleucine on brain serotonin concentration in rats.
Topics: Animals; Brain Chemistry; Depression, Chemical; Diet; Drug Interactions; Female; Isoleucine; Leucine; Male; Niacinamide; Nicotinic Acids; Pellagra; Rats; Serotonin; Serotonin Antagonists | 1972 |
[Some aspects of pellagra].
Topics: Amino Acids; Child, Preschool; Diet; Humans; Hybridization, Genetic; Infant; Kwashiorkor; Leucine; Niacinamide; Pellagra; Protein Deficiency; Skin; Vitamin B Complex; Zea mays | 1973 |
Production of nicotinic acid deficiency in monkeys fed leucine supplemented diets.
Topics: Animal Nutritional Physiological Phenomena; Animals; Blood Proteins; Body Weight; Deficiency Diseases; Erythrocytes; Haplorhini; Hemoglobins; Isoleucine; Leucine; Macaca; Niacinamide; Nicotinic Acids; Ribonucleotides; Serum Albumin; Time Factors | 1973 |
Effect of streptozotocin-diabetes on in vivo protein synthesis by placenta and liver of mice.
Topics: Animals; Blood Glucose; Body Weight; Carbon Radioisotopes; Diabetes Mellitus; Female; Insulin; Leucine; Liver; Maternal-Fetal Exchange; Mice; Niacinamide; Organ Specificity; Placenta; Pregnancy; Protein Biosynthesis; Streptozocin; Time Factors | 1974 |
[Role of some metabolic changes in the development of complications of pregnancy and labor in women with rheumatic heart disease].
Topics: Amino Acids; Calcium; Computers; Cysteine; Cystine; Female; Glutamine; Humans; Isoleucine; Leucine; Magnesium; Methionine; Niacinamide; Obstetric Labor Complications; Phenylalanine; Potassium; Pregnancy; Pregnancy Complications, Cardiovascular; Rheumatic Heart Disease; Sodium; Tryptophan; Tyrosine; Valine; Vitamin E | 1974 |
Failure of 6-aminonicotinamide to inhibit the potentiating effect of leucine and arginine on glucose-induced insulin release in vitrol.
Topics: Animals; Arginine; Drug Synergism; Female; Glucose; Hexosephosphates; Insulin; Insulin Secretion; Leucine; Niacinamide; Oxidation-Reduction; Rats | 1974 |
Liquid scintillation counting and sample adsorption. Structural factors in organic molecules controlling likelihood of adsorption.
Topics: Acetamides; Acetates; Adenine; Adsorption; Alcohols; Alkanes; Anhydrides; Antipyrine; Azo Compounds; Barbiturates; Benzoates; Benzyl Compounds; Carbamates; Carbon Radioisotopes; Cholesterol; Cinnamates; Cyanides; Dicarboxylic Acids; Ferrocyanides; Glucose; Glutarates; Leucine; Niacinamide; Nitrophenols; Phenoxyacetates; Scintillation Counting; Structure-Activity Relationship; Testosterone; Triazoles | 1974 |
Studies on the mode of action of diphtheria toxin. V. Inhibition of peptide bond formation by toxin and NAD in cell-free systems and its reversal by nicotinamide.
Topics: Amino Acids; Animals; Diphtheria Toxin; HeLa Cells; Horses; In Vitro Techniques; L Cells; Leucine; Mice; NAD; Niacinamide; Phenylalanine; Rabbits; Reticulocytes; Transferases | 1967 |
Tryptophan and nitrogen metabolism and pregnancy of the rat as affected by dietary supplementations with leucine and with amino acid mixtures.
Topics: Amino Acids; Animals; Deficiency Diseases; Diet; Dietary Proteins; Feces; Female; Fetal Death; Fetus; Isoleucine; Kidney; Leucine; Liver; Male; Maternal-Fetal Exchange; NAD; Niacinamide; Nicotinic Acids; Nitrogen; Pregnancy; Pregnancy, Animal; Rats; Tryptophan; Valine | 1970 |
Interaction of ADP-ribosylated aminoacyl-transferase II with GTP and with ribosomes.
Topics: Acyltransferases; Adenine Nucleotides; Adenosine Diphosphate; Animals; Binding Sites; Carbon Isotopes; Centrifugation, Density Gradient; Depression, Chemical; Dialysis; Diphtheria Toxin; Guanine Nucleotides; Hydrogen-Ion Concentration; Isoelectric Focusing; Leucine; Liver; Mathematics; NAD; Niacinamide; Rats; Ribose; Ribosomes; RNA, Transfer; Solubility; Tritium | 1971 |
[Nutritional requirements of 4 species of Trichophyton verrucosum].
Topics: Alkanesulfonates; Aspartic Acid; Buffers; Culture Media; Glucose; Glutamates; Hydrogen-Ion Concentration; Inositol; Leucine; Morpholines; Niacinamide; Nicotinic Acids; Spores, Fungal; Temperature; Thiamine; Trichophyton; Tryptophan; Vitamins | 1972 |
Metabolites and the incorporation of L-leucine into rabbit insulin in vitro.
Topics: Acetone; Amines; Animals; Azaserine; Bucladesine; Carbon Radioisotopes; Electrophoresis, Paper; Fructose; Glucose; Glyceraldehyde; Hydrolysis; Hydroxybutyrates; In Vitro Techniques; Insulin; Islets of Langerhans; Leucine; Male; Niacinamide; Pyruvates; Rabbits; Radioimmunoassay; Trioses; Tritium | 1974 |
Effect of L-leucine-supplemented diet on the nicotinamide adenine dinucleotide content of rat liver.
Topics: Animals; Diet; Dose-Response Relationship, Drug; Intestinal Absorption; Leucine; Liver; Male; NAD; Niacinamide; Nicotinic Acids; Pentosyltransferases; Rats; Rats, Inbred Strains; Tryptophan; Tryptophan Oxygenase | 1982 |
Effect of L-tryptophan and L-leucine on biosynthesis of niacin-related compounds in Saccharomyces carlsbergensis.
Topics: Culture Media; Leucine; NAD; NADP; Niacin; Niacinamide; Nicotinamidase; Pentosyltransferases; Saccharomyces; Tryptophan | 1982 |
The effects of a dietary excess of leucine on the synthesis of nicotinamide nucleotides in the rat.
Topics: Animals; Diet; Enzyme Activation; Hydrolases; Kynurenine; Leucine; Liver; Male; NADP; Niacin; Niacinamide; Pellagra; Rats; Rats, Inbred Strains; Tryptophan; Tryptophan Oxygenase | 1983 |
NAD glycohydrolase activity in the liver of rats fed on excess leucine diet and low or high protein diet.
Topics: Animals; Body Weight; Dietary Proteins; Dose-Response Relationship, Drug; Leucine; Liver; Male; NAD; NAD+ Nucleosidase; Niacin; Niacinamide; Nicotinic Acids; Rats; Rats, Inbred Strains | 1982 |
Excretion of tryptophan-niacin metabolites by young men: effects of tryptophan, leucine, and vitamin B6 intakes.
Topics: Adult; Dose-Response Relationship, Drug; Humans; Leucine; Male; Niacinamide; Nicotinic Acids; Nitrogen; Pyridoxine; Quinolinic Acids; Tryptophan | 1980 |
Biosynthesis of bicyclomycin. II. Biosynthetic conditions and incorporation of radioactive precursors into bicyclomycin by washed mycelium.
Topics: Amino Acids; Anti-Bacterial Agents; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Carbohydrates; Carbon Radioisotopes; Chloramphenicol; Ferric Compounds; Ferrous Compounds; Isoleucine; Leucine; Niacinamide; Nicotinic Acids; Streptomyces; Streptomycin | 1980 |
Effect of leucine on tryptophan metabolism.
Topics: Adult; Humans; Leucine; Male; Niacinamide; Pyridoxine; Quinolinic Acids; Socioeconomic Factors; Tryptophan | 1982 |
Differential insulin secretory activity in rat pancreatic islets and HIT cells.
Topics: Alloxan; Animals; Arginine; Cell Line; Cells, Cultured; Cricetinae; Glucose; Insulin; Insulin Antagonists; Insulin Secretion; Islets of Langerhans; Leucine; Male; Niacinamide; Rats; Rats, Wistar; Species Specificity; Streptozocin | 1994 |
Nicotinamide counteracts alcohol-induced impairment of hepatic protein metabolism in humans.
Topics: Adult; Albumins; Alcohol Drinking; Blood Glucose; Body Mass Index; Drug Interactions; Ethanol; Female; Fibrinogen; Humans; Immunoglobulin G; Insulin; Lactates; Leucine; Liver; Male; NAD; Niacinamide; Oxidation-Reduction; Proteins; Pyruvates | 1997 |
The effect of the oral administration of leucine on the metabolism of tryptophan.
Topics: Administration, Oral; Leucine; Lysine; Niacin; Niacinamide; Nicotinic Acids; Pellagra; Quinolines; Tryptophan | 1963 |
[RECENT DATA ACQUIRED ON THE METABOLISM OF NUCLEIC ACIDS, THANKS TO THE USE OF RADIO-ISOTOPES. SPECIAL CONSIDERATIONS OF THE TIES BETWEEN NUCLEIC ACID METABOLISM AND PROTEIN METABOLISM].
Topics: Adenosine Triphosphate; Animals; Brain; Carbon Isotopes; Cell Nucleus; Centrifugation; Chromatography; DNA; Estradiol; Hepatectomy; Kidney; Leucine; Liver; NAD; Niacin; Niacinamide; Nucleotidases; Nucleotides; Phosphates; Phosphorus Isotopes; Poultry; Protein Deficiency; Proteins; Rats; Research; RNA; Tyrosine | 1963 |
THE ROLE OF MAIZE IN THE PATHOGENESIS OF PELLAGRA: EFFECT OF LEUCINE ON N'-METHYLNICOTINAMIDE EXCRETION IN HUMAN ADULTS.
Topics: Adult; Edible Grain; Humans; Leucine; Niacin; Niacinamide; Nicotinic Acids; Nitrogen; Pellagra; Toxicology; Tryptophan; Urine; Zea mays | 1963 |
[SOME ASPECTS OF THE REGULATION OF RIBONUCLEIC ACID BIOSYNTHESES IN HIGHER ANIMALS].
Topics: Carcinoma, Hepatocellular; Chromatography; Leucine; Liver; Liver Neoplasms; Metabolism; NAD; Neoplasms, Experimental; Niacinamide; Nucleoproteins; Nucleotidases; Phosphorus Isotopes; Proteins; Rats; Research; RNA; RNA, Messenger; Vitamin E Deficiency | 1964 |
AMINO ACID IMBALANCE AND TRYPTOPHANNIACIN METABOLISM. I. EFFECT OF EXCESS LEUCINE ON THE URINARY EXCRETION OF TRYPTOPHAN-NIACIN METABOLITES IN RATS.
Topics: Amino Acids; Caseins; Isoleucine; Leucine; Niacin; Niacinamide; Nicotinic Acids; Nitrogen; Pharmacology; Pyridines; Rats; Research; Triticum; Tryptophan; Urine | 1965 |
STUDIES ON THE EFFECT OF TRYPTOPHAN DEFICIENCY ON THE METABOLIC PRODUCTS OF TRYPTOPHAN AND NIACIN.
Topics: Amino Acids; Blood; Creatine; Creatinine; Deficiency Diseases; Diet; Fluids and Secretions; Histidine; Isoleucine; Leucine; Lysine; Metabolism; Methionine; Niacin; Niacinamide; Nitrogen; Nucleotides; Phenylalanine; Riboflavin; Tryptophan; Urine; Valine; Xanthurenates | 1965 |
Atomic-resolution structures of horse liver alcohol dehydrogenase with NAD(+) and fluoroalcohols define strained Michaelis complexes.
Topics: Alcohol Dehydrogenase; Animals; Benzyl Alcohols; Catalytic Domain; Crystallography, X-Ray; Enzyme Inhibitors; Horses; Leucine; Ligands; Liver; Models, Molecular; Niacinamide; Oxidation-Reduction; Protein Conformation; Trifluoroethanol | 2012 |
Active site hydrophobic residues impact hydrogen tunneling differently in a thermophilic alcohol dehydrogenase at optimal versus nonoptimal temperatures.
Topics: Alcohol Dehydrogenase; Catalytic Domain; Hydrogen; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kinetics; Leucine; Models, Molecular; Mutagenesis, Site-Directed; Niacinamide; Protein Conformation; Pseudomonas aeruginosa; Static Electricity; Temperature; Valine | 2012 |
Major clinical response to a BRAF inhibitor in a patient with a BRAF L597R-mutated melanoma.
Topics: Aged; Antineoplastic Agents; Arginine; Back; Cell Survival; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Female; Humans; Imidazoles; Indoles; Leucine; Lung Neoplasms; MAP Kinase Signaling System; Melanoma; Niacinamide; Oximes; Phenylurea Compounds; Point Mutation; Proto-Oncogene Proteins B-raf; Skin Neoplasms; Sorafenib; Sulfonamides; Vemurafenib | 2013 |
Inhibitory role of the small leucine-rich proteoglycan biglycan in bladder cancer.
Topics: Animals; Biglycan; Gene Expression Regulation, Neoplastic; Humans; Indoles; Leucine; Male; Mice; Mice, Nude; Niacinamide; Phenylurea Compounds; Pyrroles; RNA, Messenger; Sorafenib; Sunitinib; Urinary Bladder Neoplasms | 2013 |
Caloric restriction mimetics: natural/physiological pharmacological autophagy inducers.
Topics: Acetyl Coenzyme A; Anacardic Acids; Animals; Autophagy; Caloric Restriction; Catalysis; Catechin; Curcumin; Food Deprivation; Humans; Leucine; Mice; Models, Animal; Niacinamide; Plant Extracts; Resveratrol; Spermidine; Starvation; Stilbenes; Terpenes | 2014 |
A CD13 inhibitor, ubenimex, synergistically enhances the effects of anticancer drugs in hepatocellular carcinoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Hepatocellular; CD13 Antigens; Cell Cycle; Cell Line, Tumor; Cisplatin; Drug Synergism; Fluorouracil; Gene Expression Regulation, Neoplastic; Humans; Leucine; Liver Neoplasms; Neoplastic Stem Cells; Niacinamide; Phenylurea Compounds; Reactive Oxygen Species; Sorafenib | 2016 |
Use of Metabolomics to Trend Recovery and Therapy After Injury in Critically Ill Trauma Patients.
Topics: Adenosine Monophosphate; Adult; Biomarkers; Biotin; Case-Control Studies; Choline; Cytidine; Fatty Acids; Female; Humans; Injury Severity Score; Isoleucine; Leucine; Male; Metabolome; Metabolomics; Middle Aged; Muscle, Skeletal; Niacinamide; Nucleotides; Oxidative Stress; Principal Component Analysis; Prospective Studies; Serine; Time Factors; Valine; Wounds, Nonpenetrating | 2016 |
Ubenimex attenuates acquired sorafenib resistance in renal cell carcinoma by inhibiting Akt signaling in a lipophagy associated mechanism.
Topics: Adenine; Animals; Autophagy; Carcinoma, Renal Cell; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Humans; Kidney Neoplasms; Leucine; Lipid Metabolism; Mice; Niacinamide; Phenylurea Compounds; Proto-Oncogene Proteins c-akt; Signal Transduction; Sorafenib; Xenograft Model Antitumor Assays | 2016 |