nevirapine and quinone methide

nevirapine has been researched along with quinone methide in 2 studies

Research

Studies (2)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (50.00)	29.6817
2010's	1 (50.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Chen, Y; Fitch, WL; Wen, B	1
Hayes, MA; Li, Y; Novalen, M; Sharma, AM; Uetrecht, J	1

Other Studies

2 other study(ies) available for nevirapine and quinone methide

Article	Year
Metabolic activation of nevirapine in human liver microsomes: dehydrogenation and inactivation of cytochrome P450 3A4. Drug metabolism and disposition: the biological fate of chemicals, 2009, Volume: 37, Issue:7 Topics: Biotransformation; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Enzyme Inhibitors; Glutathione; Hepatocytes; Humans; Indolequinones; Mass Spectrometry; Microsomes, Liver; Nevirapine; Oxidation-Reduction; Prodrugs; Spectrometry, Mass, Electrospray Ionization	2009
Bioactivation of nevirapine to a reactive quinone methide: implications for liver injury. Chemical research in toxicology, 2012, Aug-20, Volume: 25, Issue:8 Topics: Animals; Antibodies; Aryl Hydrocarbon Hydroxylases; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP3A; Cytochrome P450 Family 2; Female; Humans; Indolequinones; Male; Mice; Mice, Inbred C57BL; Microsomes, Liver; Nevirapine; Oxidation-Reduction; Rats; Rats, Inbred BN; Steroid 16-alpha-Hydroxylase	2012

Article

Year

Metabolic activation of nevirapine in human liver microsomes: dehydrogenation and inactivation of cytochrome P450 3A4.

Drug metabolism and disposition: the biological fate of chemicals, 2009, Volume: 37, Issue:7

Topics: Biotransformation; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Enzyme Inhibitors; Glutathione; Hepatocytes; Humans; Indolequinones; Mass Spectrometry; Microsomes, Liver; Nevirapine; Oxidation-Reduction; Prodrugs; Spectrometry, Mass, Electrospray Ionization

2009

Bioactivation of nevirapine to a reactive quinone methide: implications for liver injury.

Chemical research in toxicology, 2012, Aug-20, Volume: 25, Issue:8

Topics: Animals; Antibodies; Aryl Hydrocarbon Hydroxylases; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP3A; Cytochrome P450 Family 2; Female; Humans; Indolequinones; Male; Mice; Mice, Inbred C57BL; Microsomes, Liver; Nevirapine; Oxidation-Reduction; Rats; Rats, Inbred BN; Steroid 16-alpha-Hydroxylase

2012