neuropeptide-y has been researched along with linalool* in 2 studies
1 trial(s) available for neuropeptide-y and linalool
| Article | Year |
|---|---|
In vitro neuropeptide Y mRNA expressing model for screening essences that may affect appetite using Rolf B1.T cells.
Neuropeptide Y (NPY) is the most important appetite regulator. This study aimed to establish an in vitro NPY mRNA expression model for screening essences to determine if they are an appetite stimulator or inhibitor. We cultured the olfactory nerve cells Rolf B1.T for 2 days and then treated the cells with the known appetite inhibitor limonene and stimulator linalool. It was found that linalool could significantly stimulate NPY mRNA expression in 10 min, and limonene had the opposite effect. Similar results were also found in primary olfactory ensheathing cells isolated from rats. Further clinical trials using human subjects found that, when 10 min of treatment was applied, linalool indeed increased the serum NPY level in human peripheral blood. Limonene, on the other hand, decreased the serum NPY level. Thus, NPY mRNA expression in Rolf B1.T cells could be used as an in vitro model for screening essences that may affect appetite. Topics: Acyclic Monoterpenes; Adult; Animals; Appetite; Appetite Regulation; Cell Line; Cyclohexenes; Female; Gene Expression; Humans; Limonene; Male; Monoterpenes; Neuropeptide Y; Olfactory Nerve; Rats; RNA, Messenger; Terpenes | 2012 |
1 other study(ies) available for neuropeptide-y and linalool
| Article | Year |
|---|---|
Inhalation of a racemic mixture (R,S)-linalool by rats experiencing restraint stress alters neuropeptide and MHC class I gene expression in the hypothalamus.
Some odorants have physiological and psychological effects on organisms. However, little is known about the effects of inhaling them, particularly on the central nervous system. Using DNA microarray analysis, we obtained gene expression profiles of the hypothalamus from restraint stressed rats exposed to racemic (R,S)-linalool. Hierarchical clustering across all probe sets showed that this inhalation of (R,S)-linalool influenced the expression levels of a wide range of genes in the hypothalamus. A comparison of transcription levels revealed that the inhalation of (R,S)-linalool restored the expression of 560 stress-induced probe sets to a normal status. Gene Ontology (GO) analysis showed that these genes were associated with synaptic transmission via neurotransmitters including anxiolytic neuropeptides such as oxytocin and neuropeptide Y. These genes also included several major histocompatibility complex (MHC) class I molecules necessary for neural development and plasticity. Moreover, Upstream Regulator Analysis predicted that the hormone prolactin would be activated by the inhalation of (R,S)-linalool under stress. Our results reveal some of the molecular mechanisms associated with odor inhalation in the hypothalamus in organisms under stress. Topics: Acyclic Monoterpenes; Administration, Inhalation; Animals; Gene Expression; Genes, MHC Class I; Hypothalamus; Male; Monoterpenes; Neuropeptide Y; Oxytocin; Rats; Rats, Wistar; Restraint, Physical; Stress, Psychological; Up-Regulation | 2017 |