Page last updated: 2024-08-25

neplanocin a and adenosine

neplanocin a has been researched along with adenosine in 107 studies

Research

Studies (107)

Timeframe	Studies, this research(%)	All Research%
pre-1990	39 (36.45)	18.7374
1990's	20 (18.69)	18.2507
2000's	30 (28.04)	29.6817
2010's	15 (14.02)	24.3611
2020's	3 (2.80)	2.80

Authors

Authors	Studies
Dalley, NK; McKernan, PA; Nord, LD; Robins, RK	1
Davari, H; Hakimelahi, GH; Hakimelahi, S; Hwu, JR; King, KY; Mei, NW; Moosavi-Movahedi, AA; Wen, YS	1
Ackerman, JJ; Buttz, HR; Duerre, JA	1
Bartlett, WJ; Borchardt, RT; Borcherding, DR; Lee, Y; Wolfe, MS	1
Plunkett, W; Saunders, PP	1
De Clercq, E; Marquez, VE; Murase, J	1
Andrei, G; Balzarini, J; De Clercq, E; Hosoya, M; Obara, T; Shuto, S; Snoeck, R; Toriya, M	1
De Clercq, E; Obara, T; Shuto, S	1
Hanai, Y; Maruyama, T; Sato, Y	1
Bodenteich, M; Copp, RR; Lim, BB; Marquez, VE	1
Borchardt, RT; Kramer, DL; Porter, CW; Sufrin, JR	1
Robins, RK; Saunders, PP; Tan, MT	1
Fukukawa, K; Hoshi, A; Iigo, M; Tokuzen, R; Ueda, T; Yoshida, M	1
Borchardt, RT; Borcherding, DR; Hasobe, M; McKee, JG	1
Borchardt, RT; Borcherding, DR; Hasobe, M; Keller, BT; Mckee, JG	1
Cools, M; de Clercq, E	2
Balzarini, J; Borchardt, RT; Borcherding, DR; Cools, M; De Clercq, E; Drach, JC; Kitaoka, S; Konno, T; Marquez, VE	1
Borchardt, RT; Paisley, SD; Wolfe, MS	1
Borchardt, RT; Hasobe, M; McKee, JG	1
De Clercq, E	3
De Clercq, E; Kitaoka, S; Konno, T	1
Borchardt, RT; Matuszewska, B	2
Borchardt, RT; Decedue, CJ; Fisher, EW; Keller, BT	1
Borchardt, RT; Borcherding, DR; Keller, BT; Narayanan, SR; Scholtz, SA	1
De Clercq, E; Durbin, RK; Stollar, V	1
Borchardt, RT; Borcherding, DR; Hasobe, M; Keller, BT; McKee, JG; Narayanan, S	1
Chiang, PK; Glazer, RI; Hartman, KD; Knode, MC; Marquez, VE; Richard, MM; Tseng, CK	1
Brown, ND; Chiang, PK; Gordon, RK; Miura, GA; Whaun, JM	1
Ayers, DF; Narayan, P; Nilsen, TW; Ransohoff, RM; Rottman, FM	1
Allan, PW; Bennett, LL; Comber, RN; Rose, LM; Secrist, JA	1
Glazer, RI; Haines, DR; Knode, MC; Marquez, VE; Tseng, CK	1
Phadtare, S; Zemlicka, J	1
Hasobe, M; Isono, K; Saneyoshi, M	1
Cohen, MB; Glazer, RI; Hartman, KD; Knode, MC; Linevsky, J	1
Ohno, M	1
Borchardt, RT; Clark, RS; Keller, BT; Pegg, AE	1
Inaba, M; Nagashima, K; Sakurai, Y; Tsukagoshi, S	1
Abeles, RH; Chisholm, J; Fish, S; Tashjian, AH; Wolfson, G	1
Bartel, RL; Borchardt, RT	1
Glazer, RI; Knode, MC	1
Adachi, K; Arita, M; Ohno, M; Sawai, H	1
Borchardt, RT; Keller, BT; Patel-Thombre, U	1
Borchardt, RT; Keller, BT	1
Hayashi, M; Muto, N; Tsujino, M; Yaginuma, S	1
Hayashi, M; Muto, N; Otani, M; Sudate, Y; Tsujino, M; Yaginuma, S	1
Hayashi, M; Nakatsu, K; Yaginuma, S; Yoshioka, H	1
Shuto, S	1
Linder, M; Scholtissek, C; Woyciniuk, P	1
Itoh, H; Kosugi, Y; Matsuda, A; Obara, T; Saito, Y; Shigeta, S; Shuto, S; Toriya, M; Yaginuma, S	1
Driscoll, JS; Marquez, VE	1
Hirota, K; Kitade, Y; Maki, Y; Monguchi, Y	1
Bu, G; Oxenrider, KA; Sitz, TO	1
Tsiftsoglou, AS; Vizirianakis, IS	2
Andrei, G; De Clercq, E; Matsuda, A; Obara, T; Saito, Y; Shuto, S; Snoeck, R	1
Andrei, G; Balzarini, J; De Clercq, E; Matsuda, A; Obara, T; Saito, Y; Shuto, S; Snoeck, R	1
Andrei, G; Balzarini, J; De Clercq, E; Matsuda, A; Neyts, J; Obara, T; Padalko, E; Saito, Y; Sasaki, T; Shuto, S; Snoeck, R; Tanaka, M; Yamashita, K	1
Honma, Y; Kanatani, Y; Matsuda, A; Niitsu, N; Shuto, S; Umeda, M; Yamamoto-Yamaguchi, Y	1
Geisler, L; Hegedus, LS	1
Chun, MW; Jeong, LS; Kim, JH; Lee, HW; Park, SS; Shin, DH	1
Iwata, A; Kitade, Y; Nakanishi, M; Yatome, C	1
Choi, WJ; Chun, MW; Jeong, LS; Jung, YH; Kim, HO; Moon, HR; Park, JG; Yoo, SJ	1
Nagaoka, Y; Nishimura, K; Ono, M; Tomioka, K; Tsubouchi, H	1
Franzyk, H; Jensen, SR; Olsen, CE; Rasmussen, JH	1
Chun, MW; Jeong, LS; Kim, HO; Kim, JH; Lee, KM; Moon, HR	1
Baker, RO; Chu, CK; Huggins, J; Jin, YH	1
Borchardt, RT; Howell, PL; Hu, Y; Kuczera, K; Schowen, RL; Turner, MA; Wang, M; Yang, X; Yin, DH	1
Nishimura, K; Tomioka, K	1
Choi, WJ; Jeong, LS; Lee, JA; Moon, HR; Yoo, BN	1
Mosley, SL; Seley, KL; Zeng, F	1
Choi, MH; Kim, HD	1
Choi, WJ; Jeong, LS; Kim, HO; Lee, JA; Moon, HR; Shin, DH; Yoo, BN	1
Chun, MW; Jeong, LS; Kim, HO; Kim, KR; Lee, HJ; Lee, KM; Lee, SK; Moon, HR	1
Chun, MW; Hwang, KJ; Jacobson, KA; Jeong, LS; Kim, BT; Kim, HO; Kim, KR; Lee, JA; Lee, KM; Moon, HR	1
Gallos, JK; Kotoulas, SS; Koumbis, AE; Stathakis, CI	1
Chun, MW; Jeong, LS; Lee, JH; Lee, KM; Lee, SK; Moon, HR; Park, SB	1
Hong, JH; Wu, Y	1
Cho, JH; Hong, JH; Kim, SY; Oh, CH; Yoo, KH	1
Hong, JH; Kim, JW	1
Deguchi, K; Kumamoto, H; Takahashi, N; Tanaka, H	1
Khan, FA; Rout, B	1
Kumamoto, H; Tanaka, H	1
Edmont, D; Mathé, C; Périgaud, C; Ropero, SR	1
Deguchi, K; Kitade, Y; Kumamoto, H; Takahashi, N; Tanaka, H	1
Marco-Contelles, J; Nguyen Van Nhien, A; Postel, D; Soriano, E	1
Chu, CK; Jha, AK; Radi, M; Rao, JR	1
Amanatiadou, EP; Tezias, SS; Tsiftsoglou, AS; Vizirianakis, IS	1
Chandra, G; Jeong, LS; Lee, JY; Majik, MS	1
Converso, A; Fraley, ME; Garbaccio, RM; Hartingh, T; Hartman, GD; Huang, SY; Majercak, JM; McCampbell, A; Na, SJ; Ray, WJ; Savage, MJ; White, R; Wolffe, C; Yeh, S; Yu, Y; Zhang, R	1
Chai, CL; Santhanakrishnan, S; Tam, EK; Tan, YX; Yang, HY	1
Schneller, SW; Ye, W	1
Chai, CL; Goh, YL; Hill, J; Jiang, X; Lee, PL; Li, Z; Lim, CZ; Nguyen, TM; Ong, EH; Santhanakrishnan, S; Tam, EK; Tan, TW; Wong, SY; Yang, H; Yu, Q	1
Chen, F; Deng, L; Mo, Q; Song, Y; Wei, L; Wu, B; Yao, Y; Zhang, L	1
De Koning, HP; Ebiloma, GU; O'Neill, E; Seley-Radtke, KL; Wallace, LJ; Zimmermann, SC	1
Chandra, G; Chang, TS; Choi, S; Jang, JY; Jeong, LS; Kim, G; Lee, SK; Lee, Y; Moon, YW; Mulamoottil, VA; Nayak, A; Noh, M; Oh, K; Sahu, PK; Song, J	1
Agrofoglio, LA; Bessières, M; Chevrier, F; Roy, V	1
Chen, Q; Liu, C; Schneller, SW	2
Baba, M; Bal, C; Jha, AK; Kasula, M; Rozy, F; Samunuri, R; Sharon, A; Toyama, M; Yadav, M	1
Hassanali, A; Khamis, FM; Lwande, W; Mang'era, CM; Mbogo, C; Mireji, PO; Rono, MK	1
Byun, WS; Jarhad, DB; Jeong, LS; Kim, WK; Lee, SK; Yoon, JS	1
Benckendorff, C; Guinan, M; Miller, GJ; Smith, M	1
Baba, M; Ikeda, M; Moriishi, K; Muramatsu, M; Okamoto, M; Sharon, A; Toyama, M; Wakita, T; Watashi, K; Yamashita, A	1

Reviews

6 review(s) available for neplanocin a and adenosine

Article	Year
Metabolism and action of purine nucleoside analogs. Pharmacology & therapeutics, 1991, Volume: 49, Issue:3 Topics: 2-Chloroadenosine; Adenosine; Cladribine; Deoxyadenosines; Guanine; Guanosine; Humans; Purine Nucleosides; Ribavirin; Vidarabine	1991
S-adenosylhomocysteine hydrolase inhibitors as broad-spectrum antiviral agents. Biochemical pharmacology, 1987, Aug-15, Volume: 36, Issue:16 Topics: Adenosine; Adenosylhomocysteinase; Animals; Antiviral Agents; Hydrolases; Models, Biological; Tubercidin; Virus Replication	1987
[Design of S-adenosylhomocystein hydrolase (SHAase) inhibitors as potent anti-RNA viral agents]. Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 1995, Volume: 40, Issue:10 Topics: Adenosine; Adenosylhomocysteinase; Antiviral Agents; Drug Design; Hydrolases; RNA Viruses; Structure-Activity Relationship	1995
Curious (Old and New) Antiviral Nucleoside Analogues with Intriguing Therapeutic Potential. Current medicinal chemistry, 2015, Volume: 22, Issue:34 Topics: Adenosine; Amides; Antiviral Agents; Deoxyadenosines; Ebolavirus; Hepacivirus; HIV; Humans; Nucleosides; Pyrazines	2015
Recent progress for the synthesis of selected carbocyclic nucleosides. Future medicinal chemistry, 2015, Volume: 7, Issue:13 Topics: Adenosine; Animals; Antineoplastic Agents; Antiviral Agents; Drug Discovery; Guanine; Halogenation; Humans; Neoplasms; Nucleosides; Virus Diseases; Viruses	2015
Recent Advances in the Chemical Synthesis and Evaluation of Anticancer Nucleoside Analogues. Molecules (Basel, Switzerland), 2020, Apr-28, Volume: 25, Issue:9 Topics: Adenosine; Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Design; Drug Screening Assays, Antitumor; Furans; Humans; K562 Cells; Mice; Molecular Structure; Nucleosides; Oxygen; Prodrugs; Purine Nucleosides; Pyrimidinones; Thionucleosides; Vitamin E	2020

Other Studies

101 other study(ies) available for neplanocin a and adenosine

Article	Year
Synthesis, structure, and biological activity of certain 2-deoxy-beta-D-ribo-hexopyranosyl nucleosides and nucleotides. Journal of medicinal chemistry, 1987, Volume: 30, Issue:6 Topics: Adenosine Deaminase; Animals; Antineoplastic Agents; Antiviral Agents; Kinetics; Magnetic Resonance Spectroscopy; Mice; Molecular Conformation; Nucleosides; Nucleotides; Protein Kinases; X-Ray Diffraction	1987
Synthesis and biological evaluation of purine-containing butenolides. Journal of medicinal chemistry, 2001, May-24, Volume: 44, Issue:11 Topics: 4-Butyrolactone; Adenosylhomocysteinase; Animals; Antineoplastic Agents; Antiviral Agents; Crystallography, X-Ray; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Furans; Herpesvirus 3, Human; Humans; Hydrolases; Kinetics; Magnetic Resonance Spectroscopy; Mice; Purines; Stereoisomerism; Structure-Activity Relationship; Thymidine Kinase; Tumor Cells, Cultured	2001
Effect of methylation inhibitors on gene expression in HL-60 cells. Biochemistry and cell biology = Biochimie et biologie cellulaire, 1992, Volume: 70, Issue:8 Topics: Adenosine; Cell Differentiation; Gene Expression Regulation, Neoplastic; Genes, myc; Humans; Methylation; Poly A; RNA, Messenger; RNA, Neoplasm; Tretinoin; Tubercidin; Tumor Cells, Cultured	1992
4'-modified analogues of aristeromycin and neplanocin A: synthesis and inhibitory activity toward S-adenosyl-L-homocysteine hydrolase. Journal of medicinal chemistry, 1992, May-15, Volume: 35, Issue:10 Topics: Adenosine; Adenosylhomocysteinase; Animals; Cattle; Hydrolases; Liver; Phosphorylation	1992
Broad-spectrum antiviral and cytocidal activity of cyclopentenylcytosine, a carbocyclic nucleoside targeted at CTP synthetase. Biochemical pharmacology, 1991, Jun-15, Volume: 41, Issue:12 Topics: Adenosine; Amides; Antiviral Agents; Azauridine; Carbon-Nitrogen Ligases; Cell Division; Cytarabine; Cytidine; Deoxycytidine; Drug Synergism; Fluorouracil; HeLa Cells; Humans; Ligases; Nucleosides; Pyrazoles; Ribavirin; Ribonucleosides; Ribose; Thymidine; Tumor Cells, Cultured; Uracil; Virus Replication; Viruses	1991
New neplanocin analogues. 1. Synthesis of 6'-modified neplanocin A derivatives as broad-spectrum antiviral agents. Journal of medicinal chemistry, 1992, Jan-24, Volume: 35, Issue:2 Topics: Adenosine; Adenosylhomocysteinase; Animals; Antiviral Agents; Cell Line; Erythrocytes; Hydrolases; Mice; Rabbits; Stereoisomerism; Virus Replication	1992
New neplanocin analogues. Synthesis and antiviral activity of 6'-modified neplanocin A derivatives. Nucleic acids symposium series, 1991, Issue:25 Topics: Adenosine; Antiviral Agents; Molecular Structure; Oxidation-Reduction	1991
Synthesis of methylenecyclobutyl- and cyclobutenyl adenine A, potent antiviral carbocyclic analogues of oxetanocin A. Nucleic acids symposium series, 1991, Issue:25 Topics: Adenine; Adenosine; Antiviral Agents; Molecular Structure	1991
Synthesis and biological activity of novel carbocyclic nucleosides. Nucleic acids symposium series, 1990, Issue:22 Topics: Adenosine; Antibiotics, Antineoplastic; Antineoplastic Agents; Cytidine; Molecular Structure; Nucleosides	1990
Combined modulation of S-adenosylmethionine biosynthesis and S-adenosylhomocysteine metabolism enhances inhibition of nucleic acid methylation and L1210 cell growth. Cancer research, 1990, Jul-01, Volume: 50, Issue:13 Topics: Adenosine; Animals; Cell Division; DNA, Neoplasm; Homocysteine; Leukemia L1210; Methylation; Polyamines; RNA, Neoplasm; S-Adenosylhomocysteine; S-Adenosylmethionine; Time Factors	1990
Metabolism and action of neplanocin A in Chinese hamster ovary cells. Biochemical pharmacology, 1985, Aug-01, Volume: 34, Issue:15 Topics: Adenosine; Adenosine Kinase; Animals; Antibiotics, Antineoplastic; Cells, Cultured; Cricetinae; Cricetulus; Female; Nucleotides; Ovary; RNA	1985
Antitumor activity of derivatives of neplanocin A in vivo and in vitro. Journal of pharmacobio-dynamics, 1986, Volume: 9, Issue:2 Topics: Adenosine; Animals; Antibiotics, Antineoplastic; Cells, Cultured; Female; Leucine; Leukemia L1210; Male; Mice; Neoplasms, Experimental; RNA; Sarcoma 180; Uridine	1986
9-(trans-2',trans-3'-Dihydroxycyclopent-4'-enyl)-adenine and -3-deazaadenine: analogs of neplanocin A which retain potent antiviral activity but exhibit reduced cytotoxicity. Antimicrobial agents and chemotherapy, 1987, Volume: 31, Issue:11 Topics: Adenosine; Antiviral Agents; Cell Survival; DNA; RNA; Structure-Activity Relationship	1987
Effects of 9-(trans-2',trans-3'-dihydroxycyclopent-4'-enyl)-adenine and -3-deazaadenine on the metabolism of S-adenosylhomocysteine in mouse L929 cells. Molecular pharmacology, 1988, Volume: 33, Issue:6 Topics: Adenosine; Adenosine Kinase; Adenosylhomocysteinase; Animals; Cells, Cultured; DNA; Dose-Response Relationship, Drug; Homocysteine; Hydrolases; Mice; RNA; S-Adenosylhomocysteine; S-Adenosylmethionine; Structure-Activity Relationship	1988
Correlation between the antiviral activity of acyclic and carbocyclic adenosine analogues in murine L929 cells and their inhibitory effect on L929 cells S-adenosylhomocysteine hydrolase. Biochemical pharmacology, 1989, Apr-01, Volume: 38, Issue:7 Topics: Adenine; Adenosine; Adenosylhomocysteinase; Animals; Antiviral Agents; Cell Line; Fibroblasts; Hydrolases; Kinetics; Mice; Vaccinia virus; Vesicular stomatitis Indiana virus; Virus Replication	1989
Broad-spectrum antiviral activities of neplanocin A, 3-deazaneplanocin A, and their 5'-nor derivatives. Antimicrobial agents and chemotherapy, 1989, Volume: 33, Issue:8 Topics: Adenosine; Animals; Antiviral Agents; Cells, Cultured; Cytopathogenic Effect, Viral; HeLa Cells; Mice; Reoviridae; Respirovirus; Rotavirus; Simplexvirus; Vaccinia virus; Vesicular stomatitis Indiana virus; Virus Replication	1989
Oxidation of neplanocin A to the corresponding 3'-keto derivative by S-adenosylhomocysteine hydrolase. Journal of medicinal chemistry, 1989, Volume: 32, Issue:7 Topics: Adenosine; Adenosylhomocysteinase; Animals; Antiviral Agents; Cattle; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Hydrolases; Liver; Oxidation-Reduction	1989
Relationship between intracellular concentration of S-adenosylhomocysteine and inhibition of vaccinia virus replication and inhibition of murine L-929 cell growth. Antimicrobial agents and chemotherapy, 1989, Volume: 33, Issue:6 Topics: Adenosine; Adenosylhomocysteinase; Animals; Antibiotics, Antineoplastic; Cell Division; Chromatography, High Pressure Liquid; Homocysteine; Hydrolases; L Cells; Methylation; Mice; S-Adenosylhomocysteine; Time Factors; Vaccinia virus; Virus Replication	1989
Antiviral potency of adenosine analogues: correlation with inhibition of S-adenosylhomocysteine hydrolase. Biochemical and biophysical research communications, 1985, May-31, Volume: 129, Issue:1 Topics: Adenine; Adenosine; Adenosylhomocysteinase; Antibiotics, Antineoplastic; Antiviral Agents; Hydrolases; Kinetics; Measles virus; Reoviridae; Tubercidin; Vaccinia virus; Vesicular stomatitis Indiana virus; Virus Replication	1985
Antiviral and antimetabolic activities of neplanocins. Antimicrobial agents and chemotherapy, 1985, Volume: 28, Issue:1 Topics: Adenosine; Animals; Antibiotics, Antineoplastic; Antimetabolites; Antiviral Agents; HeLa Cells; Kidney; Mice; Rabbits; Simplexvirus; Vesicular stomatitis Indiana virus; Virus Diseases; Virus Replication	1985
Comparative efficacy of broad-spectrum antiviral agents as inhibitors of rotavirus replication in vitro. Antiviral research, 1986, Volume: 6, Issue:1 Topics: Adenine; Adenosine; Amides; Antiviral Agents; Cell Line; Cytidine; Dose-Response Relationship, Drug; Pyrazoles; Ribavirin; Ribonucleosides; Ribose; Rotavirus; Tubercidin; Vidarabine; Virus Replication	1986
The role of nicotinamide adenine dinucleotide in the inhibition of bovine liver S-adenosylhomocysteine hydrolase by neplanocin A. The Journal of biological chemistry, 1987, Jan-05, Volume: 262, Issue:1 Topics: Adenosine; Adenosylhomocysteinase; Animals; Cattle; Cyclic AMP; Hydrolases; Liver; NAD; Oxidation-Reduction; Spectrometry, Fluorescence	1987
Neplanocin A inhibition of S-adenosylhomocysteine hydrolase in Alcaligenes faecalis has no effect on growth of the microorganism. The Journal of antibiotics, 1987, Volume: 40, Issue:6 Topics: Adenosine; Adenosylhomocysteinase; Alcaligenes; Bacillus subtilis; Hydrolases; N-Glycosyl Hydrolases; S-Adenosylhomocysteine; S-Adenosylmethionine	1987
9-(trans-2',trans-3'-dihydroxycyclopent-4'-enyl) derivatives of adenine and 3-deazaadenine: potent inhibitors of bovine liver S-adenosylhomocysteine hydrolase. Journal of medicinal chemistry, 1988, Volume: 31, Issue:3 Topics: Adenine; Adenosine; Adenosine Deaminase; Adenosylhomocysteinase; Animals; Cattle; Hydrolases; Kinetics; Liver; NAD	1988
SVLM21, a mutant of Sindbis virus able to grow in Aedes albopictus cells in the absence of methionine, shows increased sensitivity to S-adenosylhomocysteine hydrolase inhibitors such as neplanocin A. Virology, 1988, Volume: 163, Issue:1 Topics: Adenine; Adenosine; Adenosylhomocysteinase; Aedes; Animals; Antiviral Agents; Cell Line; Genes, Viral; Hydrolases; Methionine; Methyltransferases; Mutation; S-Adenosylmethionine; Sindbis Virus; Tubercidin; Viral Plaque Assay	1988
Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 11. Molecular dissections of neplanocin A as potential inhibitors of S-adenosylhomocysteine hydrolase. Journal of medicinal chemistry, 1988, Volume: 31, Issue:9 Topics: Adenine; Adenosine; Adenosylhomocysteinase; Animals; Antibiotics, Antineoplastic; Antiviral Agents; Cattle; Cell Line; Chemical Phenomena; Chemistry; Hydrolases; Liver; Mice; Vaccinia virus; Virus Replication	1988
3-Deazaneplanocin: a new and potent inhibitor of S-adenosylhomocysteine hydrolase and its effects on human promyelocytic leukemia cell line HL-60. Biochemical and biophysical research communications, 1986, Mar-13, Volume: 135, Issue:2 Topics: Adenosine; Adenosylhomocysteinase; Animals; Cell Division; Cell Line; Cell Survival; Cricetinae; Humans; Hydrolases; Leukemia, Myeloid, Acute; Liver	1986
Antimalarial activity of neplanocin A with perturbations in the metabolism of purines, polyamines and S-adenosylmethionine. The Journal of pharmacology and experimental therapeutics, 1986, Volume: 236, Issue:1 Topics: Adenosine; Adenosylhomocysteinase; Animals; Antibiotics, Antineoplastic; Antimalarials; Erythrocytes; Humans; Hydrolases; Plasmodium falciparum; Polyamines; Purines; S-Adenosylmethionine	1986
The mechanism of inhibition of Alcaligenes faecalis S-adenosylhomocysteine hydrolase by neplanocin A. Archives of biochemistry and biophysics, 1987, Volume: 256, Issue:1 Topics: Adenosine; Adenosylhomocysteinase; Alcaligenes; Binding Sites; Hydrolases; NAD; NADP; Oxidation-Reduction	1987
Priming of influenza mRNA transcription is inhibited in CHO cells treated with the methylation inhibitor, neplanocin A. Antiviral research, 1987, Volume: 7, Issue:6 Topics: Adenosine; Animals; Antiviral Agents; Cell Line; Electrophoresis, Polyacrylamide Gel; Methylation; Nucleic Acid Hybridization; Orthomyxoviridae; RNA Caps; RNA, Messenger; RNA, Viral; Transcription, Genetic; Viral Proteins	1987
Differences in the metabolism and metabolic effects of the carbocyclic adenosine analogs, neplanocin A and aristeromycin. Molecular pharmacology, 1986, Volume: 29, Issue:4 Topics: Adenosine; Adenosine Deaminase; Adenosine Triphosphate; AMP Deaminase; Animals; Cell Division; Cell Line; Guanine; Guanosine Triphosphate; Hypoxanthine; Hypoxanthines; Isomerism; Kinetics; Leukemia L1210; Mice	1986
3-Deazaneplanocin A: a new inhibitor of S-adenosylhomocysteine synthesis and its effects in human colon carcinoma cells. Biochemical pharmacology, 1986, Dec-15, Volume: 35, Issue:24 Topics: Adenosine; Adenosylhomocysteinase; Cell Line; Colonic Neoplasms; Humans; Hydrolases; Kinetics; Methionine; Methylation; RNA, Ribosomal; RNA, Transfer; S-Adenosylhomocysteine; Uridine	1986
Synthesis and biological properties of 9-(trans-4-hydroxy-2-buten-1-yl)adenine and guanine: open-chain analogues of neplanocin A. Journal of medicinal chemistry, 1987, Volume: 30, Issue:2 Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Animals; Antibiotics, Antineoplastic; Guanine; Indicators and Reagents; Leukemia L1210; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mice; Spectrophotometry, Ultraviolet; Structure-Activity Relationship	1987
Antiviral activity and its mechanism of guanine 7-N-oxide on DNA and RNA viruses derived from salmonid. The Journal of antibiotics, 1985, Volume: 38, Issue:11 Topics: Adenosine; Animals; Anti-Bacterial Agents; Antiviral Agents; Guanine; Herpesviridae; Nucleic Acids; Rhabdoviridae; RNA, Viral; Salmon	1985
Effect of neplanocin A on differentiation, nucleic acid methylation, and c-myc mRNA expression in human promyelocytic leukemia cells. Molecular pharmacology, 1985, Volume: 28, Issue:1 Topics: Adenosine; Antimetabolites, Antineoplastic; Cell Differentiation; Cell Division; Cell Line; DNA, Neoplasm; Gene Expression Regulation; Humans; Leukemia, Myeloid, Acute; Methylation; Oncogenes; RNA, Neoplasm	1985
Creation of novel chiral synthons with enzymes: application to enantioselective synthesis of antibiotics. Ciba Foundation symposium, 1985, Volume: 111 Topics: Adenosine; Amino Acids, Diamino; Animals; Anti-Bacterial Agents; Binding Sites; Cyclohexanes; Deoxyadenosines; Enzymes; Esterases; In Vitro Techniques; Models, Chemical; Showdomycin; Stereoisomerism; Swine; Thienamycins	1985
Purification and characterization of some metabolic effects of S-neplanocylmethionine. Molecular pharmacology, 1985, Volume: 28, Issue:4 Topics: Adenosine; Adenosylmethionine Decarboxylase; Animals; Escherichia coli; Kinetics; L Cells; Male; Methionine; Methylation; Methyltransferases; Mice; Rats; S-Adenosylmethionine; Substrate Specificity	1985
Biochemical mode of cytotoxic action of neplanocin A in L1210 leukemic cells. Cancer research, 1986, Volume: 46, Issue:3 Topics: Adenosine; Adenosine Kinase; Animals; Biotransformation; Cell Survival; DNA, Neoplasm; Drug Resistance; Kinetics; Leukemia L1210; Leukemia P388; Mice; RNA, Neoplasm	1986
Neplanocin A. Actions on S-adenosylhomocysteine hydrolase and on hormone synthesis by GH4C1 cells. The Journal of biological chemistry, 1986, Apr-05, Volume: 261, Issue:10 Topics: Adenosine; Adenosylhomocysteinase; Animals; Antibiotics, Antineoplastic; Cell Line; DNA, Neoplasm; Growth Hormone; Hydrolases; Kinetics; Methylation; NAD; Oxidation-Reduction; Pituitary Neoplasms; Prolactin; Rats; RNA, Messenger	1986
Quantitation of S-adenosylhomocysteine hydrolase in mouse L929 cells using the inhibitor neplanocin A. Analytical biochemistry, 1985, Aug-15, Volume: 149, Issue:1 Topics: Adenosine; Adenosylhomocysteinase; Animals; Buffers; Chromatography, High Pressure Liquid; Dialysis; Hydrogen-Ion Concentration; Hydrolases; L Cells; Mice; Phosphates; Protein Binding	1985
Neplanocin A. A cyclopentenyl analog of adenosine with specificity for inhibiting RNA methylation. The Journal of biological chemistry, 1984, Nov-10, Volume: 259, Issue:21 Topics: Adenosine; Adenosine Deaminase Inhibitors; Antibiotics, Antineoplastic; Cell Line; Cell Survival; Coformycin; Colonic Neoplasms; DNA Replication; Humans; Kinetics; Methylation; Pentostatin; Protein Biosynthesis; Ribonucleosides; RNA, Ribosomal; Transcription, Genetic	1984
Enantioselective synthesis of new analogues of neplanocin A. Nucleic acids symposium series, 1983, Issue:12 Topics: Adenosine; Chemical Phenomena; Chemistry; Stereoisomerism; Structure-Activity Relationship	1983
Neplanocin A. A potent inhibitor of S-adenosylhomocysteine hydrolase and of vaccinia virus multiplication in mouse L929 cells. The Journal of biological chemistry, 1984, Apr-10, Volume: 259, Issue:7 Topics: Adenosine; Adenosylhomocysteinase; Animals; Antibiotics, Antineoplastic; Cattle; Hydrolases; Kinetics; L Cells; Liver; Mice; Vaccinia virus; Virus Replication	1984
Metabolic conversion of neplanocin A to S-neplanocylmethionine by mouse L 929 cells. Biochemical and biophysical research communications, 1984, Apr-16, Volume: 120, Issue:1 Topics: Adenosine; Animals; Biotransformation; L Cells; Methionine; Methyltransferases; Mice; S-Adenosylhomocysteine; S-Adenosylmethionine; Substrate Specificity	1984
Structures of neplanocins, new antitumor antibiotics. Nucleic acids symposium series, 1980, Issue:8 Topics: Adenosine; Antibiotics, Antineoplastic; Chemical Phenomena; Chemistry; Inosine; Magnetic Resonance Spectroscopy; Purine Nucleosides; Structure-Activity Relationship	1980
Studies on neplanocin A, new antitumor antibiotic. I. Producing organism, isolation and characterization. The Journal of antibiotics, 1981, Volume: 34, Issue:4 Topics: Adenosine; Animals; Antibiotics, Antineoplastic; Fermentation; Hypocreales; Mice	1981
Studies on neplanocin A, new antitumor antibiotic. II. Structure determination. The Journal of antibiotics, 1981, Volume: 34, Issue:6 Topics: Adenosine; Chemical Phenomena; Chemistry; Crystallography; Molecular Conformation; Spectrum Analysis	1981
The methyltransferase inhibitor Neplanocin A interferes with influenza virus replication by a mechanism different from that of 3-deazaadenosine. Virus research, 1995, Volume: 35, Issue:1 Topics: Adenosine; Adenosylhomocysteinase; Animals; Chick Embryo; Drug Synergism; Homocysteine; Hydrolases; Influenza A virus; Methionine; Methyltransferases; RNA Caps; RNA, Viral; S-Adenosylhomocysteine; Tubercidin; Viral Proteins; Virus Replication	1995
New neplanocin analogues. IV. 2-Fluoroneplanocin A: an adenosine deaminase-resistant equivalent of neplanocin A. Chemical & pharmaceutical bulletin, 1994, Volume: 42, Issue:8 Topics: Adenosine; Adenosine Deaminase; Animals; Antibiotics, Antineoplastic; Antiviral Agents; Drug Resistance; Fibrosarcoma; Mice; Ribavirin; RNA Viruses	1994
The design and synthesis of a new anticancer drug based on a natural product lead compound: from neplanocin A to cyclopentenyl cytosine (CPE-C). Stem cells (Dayton, Ohio), 1994, Volume: 12, Issue:1 Topics: Adenosine; Antiviral Agents; Cytidine; Drug Design; Humans; In Vitro Techniques	1994
Acyclic analogues of naplanocin A as a potential inhibitor of S-adenosylhomocysteine hydrolase. Nucleic acids symposium series, 1993, Issue:29 Topics: Adenosine; Adenosylhomocysteinase; Antibiotics, Antineoplastic; Hydrolases; Indicators and Reagents; Molecular Structure; Oxidation-Reduction	1993
Adenosine analogs inhibit the guanine-7-methylation of mRNA cap structures. FEBS letters, 1993, Feb-01, Volume: 316, Issue:3 Topics: Adenosine; Animals; Carcinoma, Ehrlich Tumor; In Vitro Techniques; Methylation; Methyltransferases; Mice; RNA Caps; S-Adenosylhomocysteine	1993
Induction of murine erythroleukemia cell differentiation is associated with methylation and differential stability of poly(A)+ RNA transcripts. Biochimica et biophysica acta, 1996, Jun-05, Volume: 1312, Issue:1 Topics: Actins; Adenosine; Animals; Cell Differentiation; Cell Division; Cycloleucine; Dimethyl Sulfoxide; Erythrocytes; Erythropoiesis; Globins; Hemoglobins; Kinetics; Leukemia, Erythroblastic, Acute; Methylation; Mice; Neoplasm Proteins; Peroxidases; Peroxiredoxin III; Peroxiredoxins; Proto-Oncogene Proteins c-myc; Ribonucleotides; RNA Caps; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine; Tumor Cells, Cultured	1996
New neplanocin analogues. 6. Synthesis and potent antiviral activity of 6'-homoneplanocin A1. Journal of medicinal chemistry, 1996, Jun-07, Volume: 39, Issue:12 Topics: Adenosine; Adenosylhomocysteinase; Animals; Antiviral Agents; Arenaviruses, New World; Cattle; Chlorocebus aethiops; Cyclopentanes; Cytomegalovirus; Drug Design; Enzyme Inhibitors; Fibroblasts; HeLa Cells; Herpesviridae; Humans; Hydrolases; Molecular Structure; Parainfluenza Virus 3, Human; Picornaviridae; Rabbits; Structure-Activity Relationship; Togaviridae; Vaccinia virus; Vero Cells; Vesicular stomatitis Indiana virus	1996
New neplanocin analogues. 7. Synthesis and antiviral activity of 2-halo derivatives of neplanocin A. Journal of medicinal chemistry, 1996, Sep-13, Volume: 39, Issue:19 Topics: Adenosine; Animals; Antiviral Agents; Arenaviridae; Chlorocebus aethiops; Cytomegalovirus; Molecular Structure; Parainfluenza Virus 3, Human; Reoviridae; Vaccinia virus; Vero Cells; Vesicular stomatitis Indiana virus	1996
New neplanocin analogues. VIII. Synthesis and biological activity of 6'-C-ethyl, -ethenyl, and -ethynyl derivatives of neplanocin A. Chemical & pharmaceutical bulletin, 1997, Volume: 45, Issue:7 Topics: Adenosine; Adenosine Deaminase Inhibitors; Adenosylhomocysteinase; Animals; Antiviral Agents; Chlorocebus aethiops; Enzyme Inhibitors; Hydrolases; Mice; Molecular Structure; Stereoisomerism; Vero Cells	1997
Neplanocin A, a potent inhibitor of S-adenosylhomocysteine hydrolase, potentiates granulocytic differentiation of acute promyelocytic leukemia cells induced by all-trans retinoic acid. Experimental hematology, 1997, Volume: 25, Issue:12 Topics: Adenosine; Adenosylhomocysteinase; Antibiotics, Antineoplastic; Antineoplastic Agents; Cell Cycle; Cell Differentiation; Cytarabine; Daunorubicin; DNA, Neoplasm; Drug Synergism; Enzyme Inhibitors; Granulocytes; Humans; Hydrolases; Leukemia, Promyelocytic, Acute; Leukopoiesis; Tretinoin; Tumor Cells, Cultured	1997
Synthesis of (+)-neplanocin A from a chromium-carbene complex-derived optically active butenolide. The Journal of organic chemistry, 2000, Jun-30, Volume: 65, Issue:13 Topics: 4-Butyrolactone; Adenosine; Antibiotics, Antineoplastic; Antiviral Agents; Furans; Indicators and Reagents; Molecular Conformation; Stereoisomerism	2000
Synthesis of (-)-neplanocin A analogues as potential antiviral agents. Archives of pharmacal research, 2000, Volume: 23, Issue:4 Topics: Adenosine; Antiviral Agents	2000
Purification and properties of recombinant Plasmodium falciparum S-adenosyl-L-homocysteine hydrolase. Journal of biochemistry, 2001, Volume: 129, Issue:1 Topics: Adenosine; Adenosylhomocysteinase; Animals; Enzyme Inhibitors; Escherichia coli; Hydrogen-Ion Concentration; Hydrolases; Kinetics; Molecular Weight; Plasmodium falciparum; Reaction Time; Recombinant Proteins; Temperature	2001
Syntheses of D- and L-cyclopentenone derivatives using ring-closing metathesis: versatile intermediates for the synthesis of D- and L-carbocyclic nucleosides. The Journal of organic chemistry, 2001, Sep-21, Volume: 66, Issue:19 Topics: Adenosine; Adenosylhomocysteinase; Ascorbic Acid; Cyclopentanes; Hydrolases; Nucleosides	2001
Total synthesis of (-)-neplanocin a by using lithium thiolate-initiated Michael-aldol tandem cyclization reaction. The Journal of organic chemistry, 2001, Nov-30, Volume: 66, Issue:24 Topics: Adenosine; Adenosylhomocysteinase; Antibiotics, Antineoplastic; Cyclization; Enzyme Inhibitors; Hydrolases; Lithium Compounds; Mannitol; Mesylates	2001
Synthesis of novel hydroxymethyl substituted analogues related to carbovir and neplanocin A. Nucleosides, nucleotides & nucleic acids, 2002, Volume: 21, Issue:1 Topics: Adenosine; Dideoxynucleosides; Nucleosides	2002
Stereoselective synthesis of a novel apio analogue of neplanocin A as potential S-adenosylhomocysteine hydrolase inhibitor. Organic letters, 2002, Oct-03, Volume: 4, Issue:20 Topics: Adenosine; Adenosylhomocysteinase; Enzyme Inhibitors; Hydrolases; Molecular Structure; Stereoisomerism	2002
Antiviral activity of cyclopentenyl nucleosides against orthopox viruses (Smallpox, monkeypox and cowpox). Bioorganic & medicinal chemistry letters, 2003, Jan-06, Volume: 13, Issue:1 Topics: Adenosine; Animals; Antiviral Agents; Cell Line; Cell Survival; Cowpox virus; Cytidine; Monkeypox virus; Nucleosides; Orthopoxvirus; Structure-Activity Relationship; Variola virus	2003
Catalytic strategy of S-adenosyl-L-homocysteine hydrolase: transition-state stabilization and the avoidance of abortive reactions. Biochemistry, 2003, Feb-25, Volume: 42, Issue:7 Topics: Adenosine; Adenosylhomocysteinase; Binding Sites; Buffers; Catalysis; Crystallization; Crystallography, X-Ray; Enzyme Inhibitors; Enzyme Stability; Humans; Hydrolases; Hydrolysis; NAD; Oxidation-Reduction; Pregnancy Proteins; Protein Conformation; Protein Structure, Tertiary; Substrate Specificity; Water	2003
Asymmetric conjugate addition of arylthiols to enoates and its application to organic synthesis of biologically potent compounds. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2003, Volume: 123, Issue:1 Topics: Adenosine; Catalysis; Chemistry, Organic; Cyclization; Ligands; Lithium; Molecular Conformation; Organic Chemistry Phenomena; Stereoisomerism; Sulfhydryl Compounds	2003
Synthesis of apio analogues of neplanocin A as potential inhibitors of S-adenosylhomocysteine hydrolase. Nucleic acids research. Supplement (2001), 2003, Issue:3 Topics: Adenosine; Adenosylhomocysteinase; Enzyme Inhibitors; Hydrolases	2003
Carbocyclic isoadenosine analogues of neplanocin A. Organic letters, 2003, Nov-13, Volume: 5, Issue:23 Topics: Adenosine	2003
Synthesis of novel carboacyclic nucleosides with vinyl bromide moiety as open-chain analogues of neplanocin A. Archives of pharmacal research, 2003, Volume: 26, Issue:12 Topics: Adenosine; Nucleosides; Vinyl Compounds	2003
Preparative and stereoselective synthesis of the versatile intermediate for carbocyclic nucleosides: effects of the bulky protecting groups to enforce facial selectivity. The Journal of organic chemistry, 2004, Apr-02, Volume: 69, Issue:7 Topics: Adenosine; Catalysis; Chemistry, Organic; Molecular Structure; Nucleosides; Oxidation-Reduction; Ribose; Stereoisomerism; Structure-Activity Relationship	2004
Synthesis of 5'-substituted fluoro-neplanocin A analogues: importance of a hydrogen bonding donor at 5'-position for the inhibitory activity of S-adenosylhomocysteine hydrolase. Bioorganic & medicinal chemistry letters, 2004, Nov-15, Volume: 14, Issue:22 Topics: Adenosine; Adenosylhomocysteinase; Cell Line, Tumor; Cell Survival; Humans; Hydrogen Bonding; Molecular Structure; Structure-Activity Relationship	2004
Blockade of murine erythroleukemia cell differentiation by hypomethylating agents causes accumulation of discrete small poly(A)- RNAs hybridized to 3'-end flanking sequences of beta(major) globin gene. Biochimica et biophysica acta, 2005, Mar-22, Volume: 1743, Issue:1-2 Topics: Adenosine; Animals; Base Sequence; Blotting, Northern; Cell Differentiation; Cell Line, Tumor; Cell Survival; Cells, Cultured; Cycloleucine; Cytoplasm; Dimethyl Sulfoxide; DNA; DNA Methylation; DNA Primers; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Globins; Kruppel-Like Transcription Factors; Leukemia, Erythroblastic, Acute; Mice; Models, Genetic; Molecular Sequence Data; Poly A; Repressor Proteins; RNA; RNA, Messenger; Transcription Factor AP-1; Transcription Factors; Transcriptional Activation	2005
Synthesis of novel apio carbocyclic nucleoside analogues as selective a(3) adenosine receptor agonists. The Journal of organic chemistry, 2005, Jun-24, Volume: 70, Issue:13 Topics: Adenosine; Adenosine A3 Receptor Agonists; Adenosylhomocysteinase; Combinatorial Chemistry Techniques; Enzyme Inhibitors; Molecular Structure; Receptors, Purinergic P1	2005
An improved approach to chiral cyclopentenone building blocks. Total synthesis of pentenomycin I and neplanocin A. The Journal of organic chemistry, 2005, Aug-19, Volume: 70, Issue:17 Topics: Adenosine; Cyclopentanes; Magnetic Resonance Spectroscopy; Mass Spectrometry; Stereoisomerism	2005
Structure-activity relationship of 5'-substituted fluoro-neplanocin a analogues as potent inhibitors of S-adenosylhomocysteine hydrolase. Nucleosides, nucleotides & nucleic acids, 2005, Volume: 24, Issue:5-7 Topics: Adenosine; Adenosylhomocysteinase; Antiviral Agents; Catalysis; Chemistry, Pharmaceutical; Drug Design; Enzyme Inhibitors; Hydrogen; Hydrogen Bonding; Inhibitory Concentration 50; Models, Chemical; Structure-Activity Relationship; Temperature	2005
Synthesis and biological activity of novel acyclic versions of Neplanocin A. Archiv der Pharmazie, 2005, Volume: 338, Issue:11 Topics: Adenosine; Anti-HIV Agents; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; HIV-1; Humans; Molecular Structure; Structure-Activity Relationship; Virus Replication	2005
Synthesis and antiviral evaluation of novel open-chain analogues of neplanocin A. Nucleosides, nucleotides & nucleic acids, 2006, Volume: 25, Issue:3 Topics: Adenosine; Antiviral Agents; Cell Line; Herpesvirus 1, Human; Herpesvirus 2, Human; Humans	2006
Simple synthesis of novel acyclic (e)-bromovinyl nucleosides as potential antiviral agents. Nucleosides, nucleotides & nucleic acids, 2006, Volume: 25, Issue:8 Topics: Adenosine; Antiviral Agents; Bromides; Nucleosides; Uracil	2006
Synthesis of novel 4'-modified neplanocin A analogues based on radical-mediated sulfur-extrusive stannylation. Nucleic acids symposium series (2004), 2004, Issue:48 Topics: Adenosine; Chemistry Techniques, Analytical; Free Radicals; Sulfur; Tin Compounds	2004
A formal total synthesis of (+/-)-neplanocin A. The Journal of organic chemistry, 2007, Aug-31, Volume: 72, Issue:18 Topics: Adenosine; Antineoplastic Agents; Antiviral Agents; Molecular Structure	2007
Synthesis of 5'-branched neplanocin A analogues based on radical-mediated sulfur-extrusive stannylation. Nucleic acids symposium series (2004), 2007, Issue:51 Topics: Adenosine; Adenosylhomocysteinase; Antiviral Agents; Enzyme Inhibitors; Free Radicals; Organotin Compounds; Sulfur	2007
Stereospecific synthesis of (-)-neplanocin F. Nucleosides, nucleotides & nucleic acids, 2007, Volume: 26, Issue:8-9 Topics: Adenosine; Methods; Molecular Structure; Nucleosides; Stereoisomerism	2007
Synthesis of novel 4'-modified neplanocin A analogues and their inhibitory activity against S-adenosyl-L-l-homocysteine hydrolase. Nucleosides, nucleotides & nucleic acids, 2007, Volume: 26, Issue:6-7 Topics: Adenosine; Adenosylhomocysteinase; Enzyme Inhibitors; Sulfur	2007
The synthesis of polyoxygenated, enantiomerically pure cyclopentane derivatives on route to neplanocin A stereoisomers via alkylidenecarbene species prepared from sugar templates. Carbohydrate research, 2009, Sep-08, Volume: 344, Issue:13 Topics: Adenosine; Carbohydrates; Cyclopentanes; Magnetic Resonance Spectroscopy; Methane; Models, Molecular; Molecular Conformation; Oxygen; Quantum Theory; Stereoisomerism	2009
A convergent approach for the synthesis of ara-neplanocin a analogues under subzero microwave assisted conditions. Nucleosides, nucleotides & nucleic acids, 2009, Volume: 28, Issue:5 Topics: Adenosine; Antiviral Agents; Microwaves	2009
Cloning and characterization of polyA- RNA transcripts encoded by activated B1-like retrotransposons in mouse erythroleukemia MEL cells exposed to methylation inhibitors. BMB reports, 2012, Volume: 45, Issue:2 Topics: Adenosine; Animals; beta-Globins; Cell Differentiation; Cell Line, Tumor; Cloning, Molecular; Cycloleucine; Dimethyl Sulfoxide; DNA Methylation; Leukemia, Erythroblastic, Acute; Mice; Molecular Sequence Data; Poly A; Retroelements; RNA	2012
Stereoselective synthesis of fluoro-homoneplanocin A as a potential antiviral agent. Organic letters, 2012, Apr-20, Volume: 14, Issue:8 Topics: Adenosine; Antiviral Agents; Aspergillus niger; Molecular Structure; Oxidation-Reduction; Ribose; Stereoisomerism	2012
Adenosine analogue inhibitors of S-adenosylhomocysteine hydrolase. Bioorganic & medicinal chemistry letters, 2014, Jun-15, Volume: 24, Issue:12 Topics: Adenosine; Animals; Brain Chemistry; Drug Design; Enzyme Activation; Enzyme Inhibitors; Homocysteine; Hydrogen Bonding; Hydrolases; Inhibitory Concentration 50; Models, Molecular; Rats; S-Adenosylhomocysteine; Substrate Specificity	2014
Synthesis of neplanocin A and its 3'-epimer via an intramolecular Baylis-Hillman reaction. The Journal of organic chemistry, 2014, Sep-05, Volume: 79, Issue:17 Topics: Adenosine; Catalysis; Combinatorial Chemistry Techniques; Cyclopentanes; Molecular Structure; Stereoisomerism	2014
The enantiomers of the 1',6'-isomer of neplanocin A: synthesis and antiviral properties. Bioorganic & medicinal chemistry, 2014, Oct-01, Volume: 22, Issue:19 Topics: Adenosine; Antiviral Agents; Cytomegalovirus; Dengue Virus; Dose-Response Relationship, Drug; Ebolavirus; Hepatitis B virus; Measles virus; Microbial Sensitivity Tests; Molecular Structure; Norovirus; Stereoisomerism; Structure-Activity Relationship; Vaccinia virus	2014
3-Deazaneplanocin A and neplanocin A analogues and their effects on apoptotic cell death. ChemMedChem, 2015, Volume: 10, Issue:1 Topics: Adenosine; Adenosylhomocysteinase; Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Enzyme Inhibitors; HCT116 Cells; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms; Structure-Activity Relationship; Transplantation, Heterologous	2015
Inhibition of histone H3K79 methylation selectively inhibits proliferation, self-renewal and metastatic potential of breast cancer. Oncotarget, 2014, Nov-15, Volume: 5, Issue:21 Topics: Adenosine; Animals; Apoptosis; Blotting, Western; Breast Neoplasms; Cell Cycle; Cell Differentiation; Cell Movement; Cell Proliferation; DNA Methylation; Enzyme Inhibitors; Female; Flow Cytometry; Histone-Lysine N-Methyltransferase; Histones; Humans; Immunoenzyme Techniques; Lysine; Methyltransferases; Mice; Mice, Nude; Neoplastic Stem Cells; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured; Xenograft Model Antitumor Assays	2014
Design and synthesis of a series of truncated neplanocin fleximers. Molecules (Basel, Switzerland), 2014, Dec-16, Volume: 19, Issue:12 Topics: Adenosine; Adenosylhomocysteinase; Biological Transport; Drug Design; Drug Evaluation, Preclinical; Inhibitory Concentration 50; Protozoan Proteins; Trypanocidal Agents; Trypanosoma brucei brucei	2014
Structure-Activity Relationships of Neplanocin A Analogues as S-Adenosylhomocysteine Hydrolase Inhibitors and Their Antiviral and Antitumor Activities. Journal of medicinal chemistry, 2015, Jun-25, Volume: 58, Issue:12 Topics: Adenine; Adenosine; Adenosylhomocysteinase; Animals; Antineoplastic Agents; Antiviral Agents; Cell Line, Tumor; Chlorocebus aethiops; Enzyme Inhibitors; Humans; Molecular Docking Simulation; Neoplasms; Structure-Activity Relationship; Vero Cells; Virus Diseases; Viruses	2015
Enantiomeric 3-deaza-1',6'-isoneplanocin and its 3-bromo analogue: Synthesis by the Ullmann reaction and their antiviral properties. Bioorganic & medicinal chemistry letters, 2016, Feb-01, Volume: 26, Issue:3 Topics: Adenine; Adenosine; Adenosylhomocysteinase; Antiviral Agents; Cytomegalovirus; Ebolavirus; Humans; Morbillivirus; Norovirus; Nucleosides; Stereoisomerism	2016
Synthesis and anti-HBV activity of α-stereoisomer of aristeromycin based analogs. Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16 Topics: Adenosine; Antiviral Agents; Cell Line; Cell Survival; Crystallography, X-Ray; Cyclopentanes; Hepatitis B virus; Humans; Molecular Conformation; Pyrimidines; Stereoisomerism; Virus Replication	2016
Both enantiomers of 6'-Isoneplanocin. Nucleosides, nucleotides & nucleic acids, 2017, Oct-03, Volume: 36, Issue:10 Topics: Adenosine; Antiviral Agents; Models, Molecular; Molecular Conformation; Stereoisomerism	2017
Growth-disrupting Murraya koenigii leaf extracts on Anopheles gambiae larvae and identification of associated candidate bioactive constituents. Acta tropica, 2019, Volume: 190 Topics: Adenosine; Animals; Anopheles; Chromatography, Liquid; Female; Insecticides; Kenya; Larva; Locomotion; Mass Spectrometry; Murraya; Plant Extracts; Plant Leaves	2019
Antiproliferative and Antimigration Activities of Fluoro-Neplanocin A via Inhibition of Histone H3 Methylation in Triple-Negative Breast Cancer. Biomolecules, 2020, 03-31, Volume: 10, Issue:4 Topics: Adenosine; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Halogenation; Histone-Lysine N-Methyltransferase; Histones; Humans; Methylation; Triple Negative Breast Neoplasms	2020
Novel Neplanocin A Derivatives as Selective Inhibitors of Hepatitis B Virus with a Unique Mechanism of Action. Antimicrobial agents and chemotherapy, 2022, 06-21, Volume: 66, Issue:6 Topics: Adenosine; Antiviral Agents; DNA, Viral; Hepatitis B; Hepatitis B virus; Humans; RNA; Virus Replication	2022