nepheline and soda-lime

In the attempt to find valid alternatives to classic antibiotics and in view of current limitations in the efficacy of antimicrobial-coated or loaded biomaterials, this work is focused on the development of a new glass-ceramic with antibacterial performance together with safe biocompatibility. This bactericidal glass-ceramic composed of combeite and nepheline crystals in a residual glassy matrix has been obtained using an antimicrobial soda-lime glass as a precursor. Its inhibitory effects on bacterial growth and biofilm formation were proved against five biofilm-producing reference strains. The biocompatibility tests by using mesenchymal stem cells derived from human bone indicate an excellent biocompatibility.

Topics: Aluminum Compounds; Anti-Bacterial Agents; Apoptosis; Biofilms; Calcium Compounds; Caspase 3; Cell Adhesion; Cells, Cultured; Ceramics; Coated Materials, Biocompatible; Enzyme Activation; Escherichia coli; Humans; Mesenchymal Stem Cells; Microbial Viability; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Oxides; Silicates; Sodium Compounds; Sodium Hydroxide; Surface Properties; Thermography; Time Factors; X-Ray Diffraction