Compounds > neocarzinostatin-chromophore

neocarzinostatin-chromophore and cyclopentenone

neocarzinostatin-chromophore has been researched along with cyclopentenone* in 1 studies

Other Studies

1 other study(ies) available for neocarzinostatin-chromophore and cyclopentenone

Article	Year
Chemical synthesis and cytotoxicity of dihydroxylated cyclopentenone analogues of neocarzinostatin chromophore. Bioorganic & medicinal chemistry letters, 2003, Jun-16, Volume: 13, Issue:12 Compounds containing the naphthoate moiety of Neocarzinostatin chromophore or 2-hydroxynaphthoate have been synthesized and evaluated for cytotoxic activity against a leukemia cell line and a small panel of human-tumor cell lines. Those compounds containing a cyclopentenone moiety were active, with the carbonyl group being essential for biological activity. Topics: Antibiotics, Antineoplastic; Cell Line, Tumor; Cyclopentanes; Drug Screening Assays, Antitumor; Enediynes; HT29 Cells; Humans; Hydroxylation; Inhibitory Concentration 50; K562 Cells; Zinostatin	2003

Article

Year

Chemical synthesis and cytotoxicity of dihydroxylated cyclopentenone analogues of neocarzinostatin chromophore.

Bioorganic & medicinal chemistry letters, 2003, Jun-16, Volume: 13, Issue:12

Compounds containing the naphthoate moiety of Neocarzinostatin chromophore or 2-hydroxynaphthoate have been synthesized and evaluated for cytotoxic activity against a leukemia cell line and a small panel of human-tumor cell lines. Those compounds containing a cyclopentenone moiety were active, with the carbonyl group being essential for biological activity.

Topics: Antibiotics, Antineoplastic; Cell Line, Tumor; Cyclopentanes; Drug Screening Assays, Antitumor; Enediynes; HT29 Cells; Humans; Hydroxylation; Inhibitory Concentration 50; K562 Cells; Zinostatin

2003