neoantimycin and respirantin

neoantimycin has been researched along with respirantin* in 1 studies

Other Studies

1 other study(ies) available for neoantimycin and respirantin

Article	Year
Rare Streptomyces N-formyl amino-salicylamides inhibit oncogenic K-Ras. Organic letters, 2014, Oct-03, Volume: 16, Issue:19 During a search for inhibitors of oncogenic K-Ras, we detected two known and two new examples of the rare neoantimycin structure class from a liquid cultivation of Streptomyces orinoci, and reassigned/assigned structures to all based on detailed spectroscopic analysis and microscale C3 Marfey's and C3 Mosher chemical degradation/derivatization/analysis. SAR investigations inclusive of the biosynthetically related antimycins and respirantin, and synthetic benzoxazolone, documented a unique N-formyl amino-salicylamide pharmacophore as a potent inhibitor of oncogenic K-Ras. Topics: ATP Binding Cassette Transporter, Subfamily B; Depsipeptides; Doxorubicin; Genes, ras; Molecular Structure; Organic Chemicals; Salicylamides; Streptomyces; Structure-Activity Relationship	2014

Article

Year

Rare Streptomyces N-formyl amino-salicylamides inhibit oncogenic K-Ras.

Organic letters, 2014, Oct-03, Volume: 16, Issue:19

During a search for inhibitors of oncogenic K-Ras, we detected two known and two new examples of the rare neoantimycin structure class from a liquid cultivation of Streptomyces orinoci, and reassigned/assigned structures to all based on detailed spectroscopic analysis and microscale C3 Marfey's and C3 Mosher chemical degradation/derivatization/analysis. SAR investigations inclusive of the biosynthetically related antimycins and respirantin, and synthetic benzoxazolone, documented a unique N-formyl amino-salicylamide pharmacophore as a potent inhibitor of oncogenic K-Ras.

Topics: ATP Binding Cassette Transporter, Subfamily B; Depsipeptides; Doxorubicin; Genes, ras; Molecular Structure; Organic Chemicals; Salicylamides; Streptomyces; Structure-Activity Relationship

2014