Page last updated: 2024-09-03

neo-gambogic acid and xanthenes

neo-gambogic acid has been researched along with xanthenes in 59 studies

Compound Research Comparison

Studies (neo-gambogic acid)	Trials (neo-gambogic acid)	Recent Studies (post-2010) (neo-gambogic acid)	Studies (xanthenes)	Trials (xanthenes)	Recent Studies (post-2010) (xanthenes)
63	0	59	5,020	92	1,325

Protein Interaction Comparison

Protein	Taxonomy	neo-gambogic acid (IC50)	xanthenes (IC50)
Amine oxidase [flavin-containing] B	Homo sapiens (human)		7.42

Research

Studies (59)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (1.69)	18.7374
1990's	1 (1.69)	18.2507
2000's	0 (0.00)	29.6817
2010's	42 (71.19)	24.3611
2020's	15 (25.42)	2.80

Authors

Authors	Studies
Huang, QS; Lu, GB; Yang, XX	1
Asano, J; Chiba, K; Tada, M; Yoshii, T	1
Cheng, H; Fang, N; Li, Q; Peng, D; Su, J; Wang, M; Wang, X; Xia, L; Xu, Q; Yang, L; Zhou, A; Zhu, G	1
Chen, H; Li, Q; Su, J; Wang, F; Wang, M; Wang, X; Xia, L; Yan, F	1
Ji, O; Lu, B; Shen, Q; Sun, M; Tang, Y; Wang, K; Zhu, H	1
Cheng, H; Li, Q; Wang, M; Yang, L	1
Chen, HB; Huang, L; Li, QL; Mei, L; Shi, XJ; Wang, XS; Zhou, LZ	1
Cheng, H; Li, QL; Peng, JY; Su, JJ; Wang, M; Wang, XC; Wang, XS; Yan, FG	1
Chang, HC; Cheng, H; Li, J; Li, Q; Li, X; Su, J; Wang, M; Wang, X; Wu, H; Xia, L; Yan, F	1
Gao, J; Han, QB; Ma, L; Wen, ZS; Yu, XJ; Zhou, GB	1
Guan, SH; Guo, DA; Tao, SJ; Wang, Y; Zhang, X	1
Chen, WD; Chen, YJ; Huang, X; Li, QL; Peng, DY; Wang, DL; Wang, XS	1
Chen, L; Fan, Y; He, S; Nie, C; Peng, A; Shao, X	1
Bin, L; Cheng, P; Dong, C; Fenggen, Y; Guanghui, W; Hui, C; Jingjing, S; Mei, W; Meiling, S; Qinglin, L; Xiaoshan, W; Yawen, H; Zhiwu, C	1
Lu, BB; Luo, YH; Tian, Y; Wang, JR; Wang, KM; Zhou, J	1
Chen, JP; Wang, CY; Wang, DL; Wang, SS; Yang, LL	1
Chang, HC; Cheng, H; Hu, Y; Li, Q; Su, J; Wang, M; Xie, C; Zhang, D	1
Cheng, H; Li, QL; Wang, XC; Zhu, GQ	1
Cheng, H; Li, QL; Su, JJ; Zhang, X	1
Dong, L; Hua, X; Liang, C; Qu, X; Zhao, T	1
Cheng, H; Li, QL; Tan, YJ; Zhang, X	1
Ding, J; He, Y; Hu, X; Li, J; Lin, Y; Shi, Y; Wang, J; Wang, K; Zhu, Y	1
Chen, W; Ge, T; Ji, Z; Jia, B; Lin, T; Luo, Q; Peng, D; Wang, L; Zhang, CY; Zhu, T	1
Chen, W; Chen, Y; Li, X; Liang, Y; Liu, L; Pan, W; Wang, X; Yuan, H; Zhang, C	1
Chen, F; Hu, XD; Liu, PD; Lou, ZC; Xie, LH; Zhang, HQ; Zhang, W; Zhang, XH	1
Chen, JP; Chen, YJ; Huang, HP; Huang, P; Wang, CY; Wang, DL; Wang, SJ; Wang, SS; Yang, LL	1
Fan, C; Han, Q; Liu, Y; Wu, X; Xie, Q; Xu, C; Yu, X; Zhang, H; Zhang, X; Zhao, Q	1
Chao, J; Chen, B; Cheng, Y; Han, B; Liu, H; Wang, Z; Yao, H; Zhang, M; Zhang, W; Zhou, Z	1
Chen, W; Cheng, H; Huang, X; Lin, T; Luo, Q; Peng, D; Wang, X; Wang, Y; Zhou, K; Zhu, T	1
Wang, XB; Yu, XJ; Zhang, JX; Zhao, Q	1
Cao, W; Chen, W; Han, Z; Liu, Y; Mao, L; Qin, X; Wan, L; Wang, S; Wang, X; Wei, W; Wu, X; Xiao, M; Xu, Q; Yan, M; Ye, D; Zhang, C; Zhang, J; Zhang, Z	1
Fu, W; Lao, Y; Li, X; Meng, X; Qian, J; Tan, H; Tu, S; Xu, H; Xu, L; Xu, N; Zhang, L; Zhou, Q	1
Jia, DD; Jin, G; Li, T; Shen, Y; Wang, FF; Xu, HC	1
Chen, W; Ge, T; Peng, D; Sun, J; Tang, X; Xu, Q	1
Chen, W; Ge, T; Gui, Q; Sun, J; Tang, X; Zhang, K; Zhang, S	1
Shi, YR; Yang, Y	1
Chen, BA; Sun, R; Zhang, HM	1
Cong, JZ; Hou, JF; Li, XM; Liu, JW; Liu, SJ; Tong, L; Zhang, Y	1
Chen, W; Guo, J; Xu, Q	1
Cheng, H; Hu, RF; Li, QL; Su, JJ; Wang, YL	1
Huang, T; Jia, J; Wang, X; Xu, L; Zhang, H; Zhu, X	1
Chen, W; Peng, D; Sheng, C; Wang, F; Wang, H; Wu, Y; Ye, X	1
Chen, SX; Chen, WD; Ding, BJ; Lin, TY; Tao, YS; Xie, JL; Xun, Y; Yang, YQ; Zhang, XM; Zhu, TT	1
Chen, W; Cheng, W; Dong, Q; Hong, L; Qian, J; Wang, B; Zha, L; Zhang, C	1
Cai, H; Chen, X; Gu, W; Kang, J; Lei, H; Wang, W; Wu, YL; Xu, H; Yang, W; Yin, T; Zhang, X; Zhu, Q	1
Liu, C; Niu, H; Shen, D; Wang, Y	1
Chang, JL; Chen, WD; Ding, BJ; Lin, TY; Peng, W; Xun, Y; Yang, W; Zhao, Y	1
Wang, J; Zhao, N; Zhou, S	1
Cheng, H; Li, Q; Li, S; Su, J; Wang, M; Wang, Y	1
Bi, Y; Guo, J; Liu, Y; Pan, L; Tan, Y; Yu, X; Zhao, Q; Zhong, J	1
Gong, YF; Huang, TY; Huang, XY; Liu, XC; Wang, ZZ; Zhang, XM	1
Bao, Y; Chen, W; Dong, Q; Liu, Y; Wang, B; Yuan, T; Zha, L; Zhang, C	1
Ding, Z; Jing, F; Li, Y; Lu, B; Song, X; Tang, Z; Wu, H	1
Bäck, V; de Thonel, A; Mezger, V; Pesonen, L; Roos-Mattjus, P; Sabéran-Djoneidi, D; Svartsjö, S	1
Cheng, H; Li, Q; Wang, M; Zhan, F	1
Gong, Y; Gu, Y; Li, Y; Lu, Y; Wang, H; Wu, M	1
Fu, P; Guo, F; Hu, Y; Ma, L; Ren, Q; Tao, S; Wu, C; Yang, L	1
Cheng, H; Li, B; Li, Q; Li, S; Liu, C; Luo, S; Su, J; Wang, M; Wu, H	1
Chen, W; Pang, M; Peng, D; Sun, J; Tang, X; Xu, Q	1

Reviews

1 review(s) available for neo-gambogic acid and xanthenes

Article	Year
Anticancer activity and underlying mechanism of neogambogic acid. Chinese journal of natural medicines, 2018, Volume: 16, Issue:9 Topics: Animals; Antineoplastic Agents, Phytogenic; Garcinia; Humans; Neoplasms; Plant Extracts; Xanthenes	2018

Other Studies

58 other study(ies) available for neo-gambogic acid and xanthenes

Article	Year
[Isolation and structure of neo-gambogic acid from Gamboge (Garcinia hanburryi)]. Yao xue xue bao = Acta pharmaceutica Sinica, 1984, Volume: 19, Issue:8 Topics: Antineoplastic Agents, Phytogenic; Benzopyrans; Chemical Phenomena; Chemistry; Plants, Medicinal; Xanthenes	1984
Cytotoxic xanthones from Garcinia hanburyi. Phytochemistry, 1996, Volume: 41, Issue:3 Topics: Cell Line; Cell Survival; Humans; Magnetic Resonance Spectroscopy; Plants, Medicinal; Spectrometry, Mass, Fast Atom Bombardment; Terpenes; Xanthenes; Xanthones	1996
Gambogenic acid inhibits proliferation of A549 cells through apoptosis-inducing and cell cycle arresting. Biological & pharmaceutical bulletin, 2010, Volume: 33, Issue:3 Topics: Adenocarcinoma; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cyclin D1; Cyclooxygenase 2; Dose-Response Relationship, Drug; Down-Regulation; Female; Garcinia; Gene Expression Regulation; Humans; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Phytotherapy; Plant Extracts; Resins, Plant; RNA, Messenger; Terpenes; Xanthenes; Xanthones; Xenograft Model Antitumor Assays	2010
Gambogenic acid mediated apoptosis through the mitochondrial oxidative stress and inactivation of Akt signaling pathway in human nasopharyngeal carcinoma CNE-1 cells. European journal of pharmacology, 2011, Feb-10, Volume: 652, Issue:1-3 Topics: Apoptosis; bcl-2-Associated X Protein; Carcinoma; Cell Proliferation; Humans; Mitochondria; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Oncogene Protein v-akt; Oxidative Stress; Reactive Oxygen Species; Signal Transduction; Terpenes; Tumor Cells, Cultured; Xanthenes; Xanthones	2011
The mechanism of neogambogic acid-induced apoptosis in human MCF-7 cells. Acta biochimica et biophysica Sinica, 2011, Volume: 43, Issue:9 Topics: Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Breast Neoplasms; Caspase 3; Caspase 8; Caspase 9; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cytochromes c; Dose-Response Relationship, Drug; Fas Ligand Protein; fas Receptor; Female; G1 Phase; Garcinia; Humans; Membrane Potential, Mitochondrial; Molecular Structure; Proto-Oncogene Proteins c-bcl-2; Resting Phase, Cell Cycle; Terpenes; Xanthenes; Xanthones	2011
[Gambogenic acid inhibits proliferation of A549 cells through apoptosis-inducing]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2011, Volume: 36, Issue:9 Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cyclooxygenase 2; Humans; Immunohistochemistry; In Situ Nick-End Labeling; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Microscopy, Electron, Transmission; Terpenes; Vascular Endothelial Growth Factor A; Xanthenes; Xanthones; Xenograft Model Antitumor Assays	2011
Gambogenic acid-induced time- and dose-dependent growth inhibition and apoptosis involving Akt pathway inactivation in U251 glioblastoma cells. Journal of natural medicines, 2012, Volume: 66, Issue:1 Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Brain Neoplasms; Caspases; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; ErbB Receptors; Garcinia; Glioblastoma; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Neoplasm Invasiveness; Phosphatidylinositol 3-Kinase; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Signal Transduction; Terpenes; Time Factors; Xanthenes; Xanthones	2012
Gambogenic acid inhibits proliferation of A549 cells through apoptosis inducing through up-regulation of the p38 MAPK cascade. Journal of Asian natural products research, 2011, Volume: 13, Issue:11 Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Caspase 3; Caspase 9; Cytochromes c; Garcinia; Humans; Imidazoles; Mice; Molecular Structure; p38 Mitogen-Activated Protein Kinases; Pyridines; Terpenes; Up-Regulation; Xanthenes; Xanthones	2011
Gambogenic acid induced mitochondrial-dependent apoptosis and referred to phospho-Erk1/2 and phospho-p38 MAPK in human hepatoma HepG2 cells. Environmental toxicology and pharmacology, 2012, Volume: 33, Issue:2 Topics: Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Carcinoma, Hepatocellular; Caspase 3; Caspase 9; Cell Proliferation; Cell Shape; Cell Survival; Dose-Response Relationship, Drug; Hep G2 Cells; Humans; Liver Neoplasms; Membrane Potential, Mitochondrial; Microscopy, Electron, Transmission; Mitochondria; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; RNA, Messenger; Signal Transduction; Terpenes; Time Factors; Xanthenes; Xanthones	2012
Gambogenic acid induces G1 arrest via GSK3β-dependent cyclin D1 degradation and triggers autophagy in lung cancer cells. Cancer letters, 2012, Sep-28, Volume: 322, Issue:2 Topics: Antineoplastic Agents, Phytogenic; Autophagy; Cell Line, Tumor; Cyclin D1; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p27; Enzyme Activation; G1 Phase Cell Cycle Checkpoints; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Lung Neoplasms; Proto-Oncogene Proteins c-akt; Signal Transduction; Terpenes; TOR Serine-Threonine Kinases; Xanthenes; Xanthones	2012
Biotransformation of gambogenic acid by Chaetomium globosum CICC 2445. Natural product communications, 2012, Volume: 7, Issue:2 Topics: Antineoplastic Agents, Phytogenic; Chaetomium; HeLa Cells; Humans; Molecular Structure; Terpenes; Xanthenes; Xanthones	2012
Solid lipid nanoparticles as delivery systems for Gambogenic acid. Colloids and surfaces. B, Biointerfaces, 2013, Feb-01, Volume: 102 Topics: Animals; Calorimetry, Differential Scanning; Freeze Drying; Lipids; Nanoparticles; Rabbits; Random Allocation; Rats; Rats, Sprague-Dawley; Terpenes; Xanthenes; Xanthones	2013
Isogambogenic acid inhibits tumour angiogenesis by suppressing Rho GTPases and vascular endothelial growth factor receptor 2 signalling pathway. Journal of chemotherapy (Florence, Italy), 2013, Volume: 25, Issue:5 Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Cell Line; Cell Line, Tumor; Cell Proliferation; Cell Survival; Endothelium, Vascular; Female; Focal Adhesion Protein-Tyrosine Kinases; Human Umbilical Vein Endothelial Cells; Humans; Mice; Mice, Nude; Neovascularization, Pathologic; Plant Extracts; Plants, Medicinal; Proto-Oncogene Proteins c-akt; rho GTP-Binding Proteins; Signal Transduction; Terpenes; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2; Xanthenes; Xanthones; Xenograft Model Antitumor Assays; Zebrafish	2013
Gambogenic acid kills lung cancer cells through aberrant autophagy. PloS one, 2014, Volume: 9, Issue:1 Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Gene Knockdown Techniques; HeLa Cells; Humans; Lung Neoplasms; Lysosomes; Male; Membrane Proteins; Mice; Phagosomes; Terpenes; Xanthenes; Xanthones; Xenograft Model Antitumor Assays	2014
Gambogenic acid induction of apoptosis in a breast cancer cell line. Asian Pacific journal of cancer prevention : APJCP, 2013, Volume: 14, Issue:12 Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; Blotting, Western; Breast Neoplasms; Caspases; Cell Proliferation; Female; Flow Cytometry; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Mitochondria; Proto-Oncogene Proteins c-bcl-2; Terpenes; Tumor Cells, Cultured; Xanthenes; Xanthones; Xenograft Model Antitumor Assays	2013
Ultra-high-performance liquid chromatography tandem mass spectrometry method for the determination of gambogenic acid in dog plasma and its application to a pharmacokinetic study. Biomedical chromatography : BMC, 2014, Volume: 28, Issue:12 Topics: Administration, Intravenous; Animals; Chromatography, High Pressure Liquid; Dogs; Drug Stability; Linear Models; Male; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Xanthenes	2014
Synergistic effects of 5-fluorouracil and gambogenic acid on A549 cells: activation of cell death caused by apoptotic and necroptotic mechanisms via the ROS-mitochondria pathway. Biological & pharmaceutical bulletin, 2014, Volume: 37, Issue:8 Topics: Antineoplastic Agents; Apoptosis; Caspase 3; Caspase 9; Cell Line, Tumor; Cell Survival; Drug Synergism; Fluorouracil; Humans; Mitochondria; Necrosis; Reactive Oxygen Species; Xanthenes	2014
[Gambogenic acid induces mitochondria-dependent apoptosis in human gastric carcinoma cell line]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2014, Volume: 37, Issue:1 Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Flow Cytometry; Garcinia; Humans; Membrane Potential, Mitochondrial; Mitochondria; Reactive Oxygen Species; Signal Transduction; Stomach Neoplasms; Tumor Suppressor Protein p53; Xanthenes	2014
[Study of gambogenic acid-induced apoptosis of melanoma B16 cells through PI3K/Akt/mTOR signaling pathways]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2014, Volume: 39, Issue:9 Topics: Animals; Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Melanoma; Mice; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Signal Transduction; Terpenes; TOR Serine-Threonine Kinases; Xanthenes; Xanthones	2014
Simultaneous determination and pharmacokinetic study of gambogic acid and gambogenic acid in rat plasma after oral administration of Garcinia hanburyi extracts by LC-MS/MS. Biomedical chromatography : BMC, 2015, Volume: 29, Issue:4 Topics: Animals; Chromatography, High Pressure Liquid; Garcinia; Male; Plant Extracts; Plasma; Rats; Rats, Wistar; Tandem Mass Spectrometry; Xanthenes; Xanthones	2015
[Apoptosis of melanoma B16 cells induced by gambogenic acid]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2014, Volume: 37, Issue:3 Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Caspase 3; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Flow Cytometry; Garcinia; Melanoma, Experimental; Mice; Mitochondria; Reactive Oxygen Species; Terpenes; Xanthenes	2014
Gambogenic acid alters chemosensitivity of breast cancer cells to Adriamycin. BMC complementary and alternative medicine, 2015, Jun-12, Volume: 15 Topics: Antineoplastic Agents; Breast Neoplasms; Doxorubicin; Drug Resistance, Neoplasm; Female; Humans; MCF-7 Cells; Xanthenes	2015
A novel glyceryl monoolein-bearing cubosomes for gambogenic acid: Preparation, cytotoxicity and intracellular uptake. International journal of pharmaceutics, 2015, Sep-30, Volume: 493, Issue:1-2 Topics: Cell Culture Techniques; Cell Survival; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Colloids; Drug Delivery Systems; Drug Liberation; Endocytosis; Glycerides; Liquid Crystals; Nanoparticles; Particle Size; Polyethylenes; Polypropylenes; Xanthenes	2015
Nanosuspensions as delivery system for gambogenic acid: characterization and in vitro/in vivo evaluation. Drug delivery, 2016, Volume: 23, Issue:8 Topics: Animals; Biological Availability; Cell Line, Tumor; Chemistry, Pharmaceutical; Drug Compounding; Drug Delivery Systems; Drug Stability; Excipients; Female; Freeze Drying; Half-Life; Hep G2 Cells; Humans; Male; Nanoparticles; Particle Size; Polyethylene Glycols; Polyvinyls; Rats; Rats, Sprague-Dawley; Solubility; Solvents; Surface-Active Agents; Suspensions; Xanthenes	2016
Enhancement of radiotherapy by ceria nanoparticles modified with neogambogic acid in breast cancer cells. International journal of nanomedicine, 2015, Volume: 10 Topics: Amines; Antineoplastic Agents; Apoptosis; Autophagy; Breast Neoplasms; Cell Cycle; Cell Cycle Checkpoints; Cerium; Female; G2 Phase; Humans; MCF-7 Cells; Metal Nanoparticles; Radiation-Sensitizing Agents; Reactive Oxygen Species; Xanthenes	2015
Preparation and Characterization of Folate Targeting Magnetic Nanomedicine Loaded with Gambogenic Acid. Journal of nanoscience and nanotechnology, 2015, Volume: 15, Issue:7 Topics: Cytotoxins; Drug Delivery Systems; Folate Receptors, GPI-Anchored; Folic Acid; HeLa Cells; Humans; Nanoparticles; Xanthenes	2015
Gambogenic acid inhibits LPS-simulated inflammatory response by suppressing NF-κB and MAPK in macrophages. Acta biochimica et biophysica Sinica, 2016, Volume: 48, Issue:5 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cell Survival; Cells, Cultured; Cyclooxygenase 2; Cytokines; Drugs, Chinese Herbal; Humans; Inflammation; Inflammation Mediators; Lipopolysaccharides; Macrophages; MAP Kinase Signaling System; Mice; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Xanthenes	2016
Neogambogic acid prevents silica-induced fibrosis via inhibition of high-mobility group box 1 and MCP-1-induced protein 1. Toxicology and applied pharmacology, 2016, 10-15, Volume: 309 Topics: Animals; Cell Line; HMGB1 Protein; Macrophages, Alveolar; Male; Mice; Mice, Inbred C57BL; Pulmonary Fibrosis; Ribonucleases; Silicon Dioxide; Xanthenes	2016
Long circulation nanostructured lipid carriers for gambogenic acid: formulation design, characterization, and pharmacokinetic. Xenobiotica; the fate of foreign compounds in biological systems, 2017, Volume: 47, Issue:9 Topics: Drug Compounding; Drug Delivery Systems; Lipids; Nanostructures; Xanthenes	2017
Gambogenic acid induces proteasomal degradation of CIP2A and sensitizes hepatocellular carcinoma to anticancer agents. Oncology reports, 2016, Volume: 36, Issue:6 Topics: Antineoplastic Agents; Autoantigens; Carcinoma, Hepatocellular; Cell Proliferation; Drug Screening Assays, Antitumor; Hep G2 Cells; Humans; Inhibitory Concentration 50; Intracellular Signaling Peptides and Proteins; Liver Neoplasms; Membrane Proteins; Proteasome Endopeptidase Complex; Protein Stability; Proteolysis; Ubiquitination; Xanthenes	2016
A covalently bound inhibitor triggers EZH2 degradation through CHIP-mediated ubiquitination. The EMBO journal, 2017, 05-02, Volume: 36, Issue:9 Topics: Antineoplastic Agents; Cell Line, Tumor; Enhancer of Zeste Homolog 2 Protein; Enzyme Inhibitors; Humans; Proteolysis; Signal Transduction; Ubiquitin-Protein Ligases; Ubiquitination; Xanthenes	2017
Gambogenic acid inhibits fibroblast growth factor receptor signaling pathway in erlotinib-resistant non-small-cell lung cancer and suppresses patient-derived xenograft growth. Cell death & disease, 2018, 02-15, Volume: 9, Issue:3 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Drug Resistance, Neoplasm; Drug Synergism; ErbB Receptors; Erlotinib Hydrochloride; Female; Humans; Lung Neoplasms; Mice, Inbred BALB C; Mice, Nude; Phosphorylation; Protein Kinase Inhibitors; Receptors, Fibroblast Growth Factor; Signal Transduction; Tumor Burden; Xanthenes; Xenograft Model Antitumor Assays	2018
Neogambogic Acid Suppresses Receptor Activator of Nuclear Factor κB Ligand (RANKL)-Induced Osteoclastogenesis by Inhibiting the JNK and NF-κB Pathways in Mouse Bone Marrow-Derived Monocyte/Macrophages. Medical science monitor : international medical journal of experimental and clinical research, 2018, Apr-26, Volume: 24 Topics: Animals; Bone Marrow; Bone Marrow Cells; Cathepsin K; Cell Differentiation; Cell Proliferation; Macrophages; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Monocytes; NF-kappa B; NFATC Transcription Factors; Osteoclasts; Osteogenesis; RANK Ligand; Receptors, Calcitonin; Signal Transduction; Tartrate-Resistant Acid Phosphatase; Transcriptome; Xanthenes	2018
Effect of Gambogenic Acid on Cytochrome P450 1A2, 2B1 and 2E1, and Constitutive Androstane Receptor in Rats. European journal of drug metabolism and pharmacokinetics, 2018, Volume: 43, Issue:6 Topics: Animals; Bupropion; Chlorzoxazone; Constitutive Androstane Receptor; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2B1; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme Inducers; Dose-Response Relationship, Drug; Drug Interactions; Liver; Male; Phenacetin; Rats; Receptors, Cytoplasmic and Nuclear; Xanthenes	2018
PEGylated liposomes as delivery systems for Gambogenic acid: Characterization and in vitro/in vivo evaluation. Colloids and surfaces. B, Biointerfaces, 2018, Dec-01, Volume: 172 Topics: Administration, Intravenous; Animals; Antineoplastic Agents; Apoptosis; Cell Death; Cell Line, Tumor; Drug Delivery Systems; Liposomes; Mice, Inbred C57BL; Polyethylene Glycols; Rabbits; Rats, Sprague-Dawley; Staining and Labeling; Xanthenes	2018
[Mechanism Research of Gambogenic Acid on Proliferation,Apoptosis and Invasion of Cervical Carcinoma He La Cells]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2016, Volume: 39, Issue:6 Topics: Apoptosis; bcl-2-Associated X Protein; Cell Cycle; Cell Proliferation; Down-Regulation; Female; HeLa Cells; Humans; Mitochondria; Proto-Oncogene Proteins c-bcl-2; Up-Regulation; Uterine Cervical Neoplasms; Xanthenes	2016
Preparation of Neogambogic Acid Nanoliposomes and its Pharmacokinetics in Rats. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2018, Volume: 28, Issue:12 Topics: Animals; Drug Compounding; Liposomes; Male; Rats; Rats, Wistar; Xanthenes	2018
Gambogenic acid reverses P-glycoprotein mediated multidrug resistance in HepG2/Adr cells and its underlying mechanism. Biochemical and biophysical research communications, 2019, 01-15, Volume: 508, Issue:3 Topics: Adenosine Triphosphatases; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Hep G2 Cells; Humans; Liver Neoplasms; Mitogen-Activated Protein Kinases; NF-kappa B; Rhodamine 123; Xanthenes	2019
[Mechanism of gambogenic acid in resisting angiogenesis of lung cancer in vitro]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2018, Volume: 43, Issue:21 Topics: A549 Cells; Apoptosis; Coculture Techniques; Human Umbilical Vein Endothelial Cells; Humans; Lung Neoplasms; Neovascularization, Pathologic; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Transfection; Xanthenes	2018
Gambogenic acid inhibits the proliferation of small‑cell lung cancer cells by arresting the cell cycle and inducing apoptosis. Oncology reports, 2019, Volume: 41, Issue:3 Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Regulatory Proteins; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Garcinia; Humans; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Small Cell Lung Carcinoma; Xanthenes; Xenograft Model Antitumor Assays	2019
Time Interval of Two Injections and First-Dose Dependent of Accelerated Blood Clearance Phenomenon Induced by PEGylated Liposomal Gambogenic Acid: The Contribution of PEG-Specific IgM. Journal of pharmaceutical sciences, 2019, Volume: 108, Issue:1 Topics: Animals; Female; Immunoglobulin M; Injections; Liposomes; Liver; Male; Metabolic Clearance Rate; Polyethylene Glycols; Rats; Rats, Sprague-Dawley; Spleen; Xanthenes	2019
A novel drug delivery system of mixed micelles based on poly(ethylene glycol)-poly(lactide) and poly(ethylene glycol)-poly(ɛ-caprolactone) for gambogenic acid. The Kaohsiung journal of medical sciences, 2019, Volume: 35, Issue:12 Topics: Drug Delivery Systems; Hep G2 Cells; Humans; Micelles; Polyesters; Polyethylene Glycols; Xanthenes	2019
Preparation and preliminary pharmacokinetics study of GNA-loaded zein nanoparticles. The Journal of pharmacy and pharmacology, 2019, Volume: 71, Issue:11 Topics: Animals; Biological Availability; Delayed-Action Preparations; Drug Carriers; Drug Delivery Systems; Female; Half-Life; Male; Nanoparticles; Particle Size; Rats; Rats, Sprague-Dawley; Xanthenes; Zein	2019
Targeting USP9x/SOX2 axis contributes to the anti-osteosarcoma effect of neogambogic acid. Cancer letters, 2020, 01-28, Volume: 469 Topics: Animals; Cell Line, Tumor; Cell Proliferation; Deubiquitinating Enzymes; Garcinia; Gene Expression Regulation, Neoplastic; Heterografts; Humans; Mice; Osteosarcoma; Signal Transduction; SOXB1 Transcription Factors; Ubiquitin Thiolesterase; Ubiquitination; Xanthenes	2020
Gambogenic acid exerts anticancer effects in cisplatin‑resistant non‑small cell lung cancer cells. Molecular medicine reports, 2020, Volume: 21, Issue:3 Topics: A549 Cells; Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cisplatin; Drug Resistance, Neoplasm; G1 Phase; Humans; Lung Neoplasms; Neoplasm Proteins; Xanthenes	2020
Folic acid-modified nonionic surfactant vesicles for gambogenic acid targeting: Preparation, characterization, and in vitro and in vivo evaluation. The Kaohsiung journal of medical sciences, 2020, Volume: 36, Issue:5 Topics: A549 Cells; Animals; Apoptosis; Drug Liberation; Endocytosis; Folic Acid; Humans; Liposomes; Particle Size; Rats, Sprague-Dawley; Static Electricity; Surface-Active Agents; Tissue Distribution; Xanthenes	2020
Gambogenic acid suppresses bladder cancer cells growth and metastasis by regulating NF-κB signaling. Chemical biology & drug design, 2020, Volume: 96, Issue:5 Topics: Cell Line, Tumor; Cell Proliferation; Humans; Neoplasm Metastasis; NF-kappa B; Signal Transduction; Urinary Bladder Neoplasms; Xanthenes	2020
Gambogenic acid induces ferroptosis in melanoma cells undergoing epithelial-to-mesenchymal transition. Toxicology and applied pharmacology, 2020, 08-15, Volume: 401 Topics: Cell Line, Tumor; Cell Survival; Drugs, Chinese Herbal; Epithelial-Mesenchymal Transition; Ferroptosis; Humans; Melanoma; Skin Neoplasms; Xanthenes	2020
Gambogenic acid induces Noxa-mediated apoptosis in colorectal cancer through ROS-dependent activation of IRE1α/JNK. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2020, Volume: 78 Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Cell Survival; Colorectal Neoplasms; Endoplasmic Reticulum Stress; Endoribonucleases; Female; Humans; JNK Mitogen-Activated Protein Kinases; Mice, Inbred BALB C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Xanthenes; Xenograft Model Antitumor Assays	2020
Scar-reducing effects of gambogenic acid on skin wounds in rabbit ears. International immunopharmacology, 2021, Volume: 90 Topics: Angiogenesis Inhibitors; Angiogenic Proteins; Animals; Anti-Inflammatory Agents; Cicatrix, Hypertrophic; Collagen; Cytokines; Disease Models, Animal; Ear; Female; Inflammation Mediators; Male; Neovascularization, Physiologic; Rabbits; Signal Transduction; Skin; Wound Healing; Wounds and Injuries; Xanthenes	2021
Oral Delivery of Gambogenic Acid by Functional Polydopamine Nanoparticles for Targeted Tumor Therapy. Molecular pharmaceutics, 2021, 03-01, Volume: 18, Issue:3 Topics: Administration, Oral; Animals; Biological Availability; Cell Line, Tumor; Drug Carriers; Folic Acid; Humans; Indoles; Mice; Mice, Inbred BALB C; Nanoparticles; Particle Size; Polymers; Rats; Rats, Sprague-Dawley; Solubility; Xanthenes	2021
Role of gambogenic acid in regulating PI3K/Akt/NF-kβ signaling pathways in rat model of acute hepatotoxicity. Bioscience, biotechnology, and biochemistry, 2021, Feb-24, Volume: 85, Issue:3 Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Liver; Male; NF-kappa B; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction; Xanthenes	2021
Gambogic acid and gambogenic acid induce a thiol-dependent heat shock response and disrupt the interaction between HSP90 and HSF1 or HSF2. Cell stress & chaperones, 2021, Volume: 26, Issue:5 Topics: Cell Line, Tumor; CRISPR-Cas Systems; Heat Shock Transcription Factors; Heat-Shock Proteins; Heat-Shock Response; HSP90 Heat-Shock Proteins; Humans; Protein Binding; Sulfhydryl Compounds; Transcription Factors; Xanthenes; Xanthones	2021
Gambogenic Acid Inhibits Basal Autophagy of Drug-Resistant Hepatoma Cells and Improves Its Sensitivity to Adriamycin. Biological & pharmaceutical bulletin, 2022, Volume: 45, Issue:1 Topics: Apoptosis; Autophagy; Carcinoma, Hepatocellular; Cell Line, Tumor; Doxorubicin; Humans; Xanthenes	2022
Neogambogic acid suppresses characteristics and growth of colorectal cancer stem cells by inhibition of DLK1 and Wnt/β-catenin pathway. European journal of pharmacology, 2022, Aug-15, Volume: 929 Topics: Apoptosis; beta Catenin; Calcium-Binding Proteins; Caspase 3; Caspase 9; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Glycogen Synthase Kinase 3 beta; Humans; Membrane Proteins; Neoplastic Stem Cells; Proliferating Cell Nuclear Antigen; Wnt Signaling Pathway; Xanthenes	2022
Gambogenic acid alleviates kidney fibrosis via epigenetic inhibition of EZH2 to regulate Smad7-dependent mechanism. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2022, Volume: 106 Topics: Animals; Biological Products; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Fibronectins; Fibrosis; Folic Acid; Histones; Kidney; Kidney Diseases; Mice; RNA, Small Interfering; Transforming Growth Factor beta1; Ureteral Obstruction; Xanthenes; Xanthones	2022
Gambogenic acid antagonizes the expression and effects of long non-coding RNA NEAT1 and triggers autophagy and ferroptosis in melanoma. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022, Volume: 154 Topics: Animals; Autophagy; Cell Proliferation; Ferroptosis; Melanoma; Mice; Mice, Inbred C57BL; MicroRNAs; RNA, Long Noncoding; Xanthenes	2022
Anti-tumor Effect of Gambogenic Acid and Its Effect on CYP2C and CYP3A after Oral Administration. Chemical & pharmaceutical bulletin, 2023, May-01, Volume: 71, Issue:5 Topics: Administration, Oral; Animals; Cytochrome P-450 CYP3A; Mice; Mice, Nude; Neoplasms; Rats; RNA, Messenger; Xanthenes	2023