nelex and bisdequalinium

The dissolving effects of seven endodontic solutions on unprepared root canal walls of young intact human premolars were evaluated with the scanning electron microscopy. After incubation at 37 degrees C in distilled water or isotonic saline for 10 min the predentinal surfaces showed no changes as compared with untreated controls. The demineralizers Decal and Largal Ultra had little effect on the organic tissues but caused some decalification where mineralized dentin was exposed. Nelex caused concentration-dependent coagulation of the residual pulp tissue, making typical ring structures on the surfaces. Sodium hypochlorite at 2.5% and 5.0% dissolved most of the predentin, exposing the globular appearance of the mineralizing front. Salvizol produced small globules on otherwise intact surfaces. Dissolution of both the organic and inorganic tissue of the root canal wall would require the combined use of two of the solutions studied.

Topics: Acetates; Adolescent; Arylsulfonates; Arylsulfonic Acids; Cetrimonium Compounds; Dental Pulp Cavity; Dequalinium; Detergents; Drug Combinations; Edetic Acid; Formaldehyde; Humans; Microscopy, Electron, Scanning; Propylene Glycol; Propylene Glycols; Root Canal Therapy; Sodium Chloride; Sodium Hypochlorite; Surface-Active Agents

The dissolving effects of seven endodontic solutions on unprepared root canal walls of young intact human premolars were evaluated with the scanning electron microscope. After incubation at 37 degrees C in distilled water or isotonic saline for 10 min the predentinal surfaces showed no changes as compared with untreated controls. The demineralizers Decal and Largal Ultra had little effect on the organic tissues but caused some decalcification where mineralized dentin was exposed. Nelex caused concentration-dependent coagulation of the residual pulp tissue, making typical ring structures on the surfaces. Sodium hypochlorite at 2.5% and 5.0% dissolved most of the predentin, exposing the globular appearance of the mineralizing front. Salvizol produced small globules on otherwise intact surfaces. Dissolution of both the organic and inorganic tissue of the root canal wall would require the combined use of two of the solutions studied.

Topics: Acetates; Adolescent; Arylsulfonates; Arylsulfonic Acids; Cetrimonium Compounds; Dental Pulp Cavity; Dequalinium; Drug Combinations; Edetic Acid; Formaldehyde; Humans; Microscopy, Electron, Scanning; Root Canal Therapy; Sodium Chloride; Sodium Hypochlorite

Pulpal tissue was incubated at 37 degrees C for 10 min with various solutions used for root canal therapy. The dissolved material was assayed for hydroxyproline (HYP) and total phosphate, and the insoluble residue for HYP and dry weight. Sodium hypochlorite (NaOCl) at 5% and diluted to 2.5% showed the strongest solvent capacity measured as loss of HYP and weight from the tissue. Dilution to 0.5% significantly decreased the effectiveness of NaOCl. The absence of HYP from the NaOCl extracts suggested decomposition of this amino acid. The other solutions tested were far inferior in their ability to dissolve pulpal tissue. The demineralizing solutions tested were poor solubilizers of soft tissue; however, they caused a considerable increase in the amount of phosphate released.

Topics: Acetates; Animals; Arylsulfonates; Arylsulfonic Acids; Cattle; Cetrimonium Compounds; Dental Pulp; Dequalinium; Drug Combinations; Edetic Acid; Female; Formaldehyde; Hydroxyproline; Root Canal Therapy; Sodium Hypochlorite; Solubility