Compounds > neferine
Page last updated: 2024-09-04

neferine and ketoconazole

neferine has been researched along with ketoconazole in 2 studies

Compound Research Comparison

Studies
(neferine)		Trials
(neferine)		Recent Studies (post-2010)
(neferine)		Studies
(ketoconazole)		Trials
(ketoconazole)		Recent Studies (post-2010) (ketoconazole)
16501206,2027061,269

Protein Interaction Comparison

ProteinTaxonomyneferine (IC50)ketoconazole (IC50)
Solute carrier family 22 member 1 Homo sapiens (human)2.6
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrialHomo sapiens (human)0.34
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrialMus musculus (house mouse)0.36
Bile salt export pumpHomo sapiens (human)3.44
Steroid 17-alpha-hydroxylase/17,20 lyaseHomo sapiens (human)1.5811
ATP-dependent translocase ABCB1Mus musculus (house mouse)6.7
ATP-dependent translocase ABCB1Homo sapiens (human)4.6771
Cytochrome P450 3A4Homo sapiens (human)0.1969
Steroid 21-hydroxylaseHomo sapiens (human)6.655
Cytochrome P450 2C8Homo sapiens (human)0.06
AromataseHomo sapiens (human)1.4111
Steroid 17-alpha-hydroxylase/17,20 lyase Rattus norvegicus (Norway rat)2.0802
Polyunsaturated fatty acid lipoxygenase ALOX15Oryctolagus cuniculus (rabbit)5.425
Cholesterol side-chain cleavage enzyme, mitochondrial Rattus norvegicus (Norway rat)3.32
5-hydroxytryptamine receptor 2ARattus norvegicus (Norway rat)1.067
Cytochrome P450 2A2Rattus norvegicus (Norway rat)0.456
Cytochrome P450 11B1, mitochondrial Bos taurus (cattle)0.38
Cytochrome P450 11B1, mitochondrialHomo sapiens (human)0.162
Translocator proteinRattus norvegicus (Norway rat)3.76
Cytochrome P450 7A1 Rattus norvegicus (Norway rat)1.2975
Cytochrome P450 11B2, mitochondrialHomo sapiens (human)0.5179
ATP-dependent translocase ABCB1Mus musculus (house mouse)3.8
Thromboxane-A synthase Homo sapiens (human)2.165
Gonadotropin-releasing hormone receptorRattus norvegicus (Norway rat)2
Sodium-dependent serotonin transporterHomo sapiens (human)0.531
Type-1 angiotensin II receptorOryctolagus cuniculus (rabbit)0.0078
Cytochrome P450 4F2Homo sapiens (human)1.6
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrialHomo sapiens (human)0.4144
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)1.9036
Lanosterol 14-alpha demethylaseHomo sapiens (human)0.19
Cytochrome P450 7A1Mus musculus (house mouse)1.2975
Lanosterol 14-alpha demethylase Rattus norvegicus (Norway rat)0.083

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (50.00)29.6817
2010's1 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hu, BR; Huang, Y; Li, S; Liu, P; Wang, JL; Xiang, JZ; Zhao, LB1
Jiang, H; Ma, L; Shen, Q; Tian, Y; Wang, L; Yu, L; Zeng, S; Zhou, H; Zhou, Q; Zuo, M1

Other Studies

2 other study(ies) available for neferine and ketoconazole

ArticleYear
[Metabolic products and pathway of neferine in rat liver].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2007, Volume: 42, Issue:10

    Topics: Administration, Oral; Alcohol Oxidoreductases; Animals; Aryl Hydrocarbon Hydroxylases; Benzylisoquinolines; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Cytochrome P450 Family 2; Isoquinolines; Ketoconazole; Male; Microsomes, Liver; Nelumbo; Phenols; Plants, Medicinal; Quinidine; Rats; Seeds; Spectrometry, Mass, Electrospray Ionization

2007
Demethylation of neferine in human liver microsomes and formation of quinone methide metabolites mediated by CYP3A4 accentuates its cytotoxicity.
    Chemico-biological interactions, 2014, Dec-05, Volume: 224

    Topics: Acetylcysteine; Animals; Antineoplastic Agents; Benzylisoquinolines; Buthionine Sulfoximine; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dogs; Glutathione; Hep G2 Cells; Humans; Indolequinones; Ketoconazole; Kinetics; Madin Darby Canine Kidney Cells; Microsomes, Liver; Troleandomycin

2014