nefazodone and buspirone

nefazodone has been researched along with buspirone in 29 studies

Research

Studies (29)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	4 (13.79)	18.2507
2000's	10 (34.48)	29.6817
2010's	15 (51.72)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Cleves, AE; Jain, AN; Kirshner, D; Langham, JJ; Spitzer, R	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Alelyunas, YW; Bui, K; Empfield, JR; McCarthy, D; Pelosi-Kilby, L; Shen, C; Spreen, RC	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Barber, J; Dawson, S; Kenna, JG; Paul, N; Stahl, S	1
Ballard, TE; Henderson, JL; Kalgutkar, AS; Obach, RS; Orr, ST; Ripp, SL; Scott, DO; Sun, H	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Dalvie, D; Loi, CM; Smith, DA	1
Bellman, K; Knegtel, RM; Settimo, L	1
Aleo, MD; Bonin, PD; Luo, Y; Potter, DM; Swiss, R; Will, Y	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y	1
Copp, JE; Robinson, DS; Schwiderski, UE	1
Sussman, N	1
McBrayer, RH; Rose, FV; Ware, JC	1
Yonkers, KA	1
Fava, M	1
Andersch, B; Eriksson, E; Eriksson, O; Landén, M; Naessén, T; Sundblad, C	1
Atherton, J; Feng, B; Hanson, J; Kalgutkar, AS; Kostrubsky, SE; Kubik, R; Kulkarni, S; Mireles, R; Mutlib, AE; Strom, SC; Urda, E	1
Dunn, MC; Dykens, JA; Jamieson, JD; Marroquin, LD; Nadanaciva, S; Smith, AR; Will, Y; Xu, JJ	1
Preskorn, SH	1
Kalgutkar, AS; Obach, RS; Soglia, JR; Zhao, SX	1
Budney, A; el-Guebaly, N; Elkashef, A; Gruber, A; Haney, M; Huestis, M; Vocci, F	1

Reviews

6 review(s) available for nefazodone and buspirone

Article	Year
Mechanism-based inactivation (MBI) of cytochrome P450 enzymes: structure-activity relationships and discovery strategies to mitigate drug-drug interaction risks. Journal of medicinal chemistry, 2012, Jun-14, Volume: 55, Issue:11 Topics: Animals; Apoproteins; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Drug Interactions; Heme; Humans; Models, Biological; Pharmacokinetics; Structure-Activity Relationship; Time Factors	2012
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
The potential benefits of serotonin receptor-specific agents. The Journal of clinical psychiatry, 1994, Volume: 55 Suppl Topics: Antidepressive Agents; Buspirone; Depressive Disorder; Humans; Isoxazoles; Ondansetron; Piperazines; Piperidines; Receptors, Serotonin; Risperidone; Selective Serotonin Reuptake Inhibitors; Serotonin; Sumatriptan; Triazoles	1994
Anxiety symptoms and anxiety disorders: how are they related to premenstrual disorders? The Journal of clinical psychiatry, 1997, Volume: 58 Suppl 3 Topics: 1-Naphthylamine; Adult; Age of Onset; Anxiety; Anxiety Disorders; Buspirone; Carbon Dioxide; Comorbidity; Depressive Disorder; Diagnosis, Differential; Female; Humans; Mental Disorders; Panic Disorder; Piperazines; Premenstrual Syndrome; Psychotherapy; Risk Factors; Sertraline; Sodium Lactate; Triazoles	1997
New approaches to the treatment of refractory depression. The Journal of clinical psychiatry, 2000, Volume: 61 Suppl 1 Topics: Antidepressive Agents; Buspirone; Depressive Disorder; Drug Therapy, Combination; Humans; Lithium; Mianserin; Mirtazapine; Monoamine Oxidase Inhibitors; Morpholines; Pindolol; Piperazines; Reboxetine; Selective Serotonin Reuptake Inhibitors; Thyroxine; Triazoles; Triiodothyronine	2000
Marijuana neurobiology and treatment. Substance abuse, 2008, Volume: 29, Issue:3 Topics: Brain; Buspirone; Cannabis; Cognitive Behavioral Therapy; Dronabinol; Humans; Marijuana Abuse; Narcotic Antagonists; Piperazines; Social Facilitation; Triazoles	2008

Trials

3 trial(s) available for nefazodone and buspirone

Article	Year
Symptom comorbidity in anxiety and depressive disorders. Journal of clinical psychopharmacology, 1990, Volume: 10, Issue:3 Suppl Topics: Adult; Anti-Anxiety Agents; Anxiety Disorders; Buspirone; Depressive Disorder; Double-Blind Method; Female; Humans; Male; Panic; Personality Assessment; Piperazines; Psychometrics; Pyrimidines; Randomized Controlled Trials as Topic; Triazoles	1990
The acute effects of nefazodone, trazodone and buspirone on sleep and sleep-related penile tumescence in normal subjects. Sleep, 1994, Volume: 17, Issue:6 Topics: Adult; Analysis of Variance; Antidepressive Agents; Buspirone; Double-Blind Method; Humans; Male; Penile Erection; Piperazines; Reference Values; Sleep; Trazodone; Triazoles	1994
Compounds with affinity for serotonergic receptors in the treatment of premenstrual dysphoria: a comparison of buspirone, nefazodone and placebo. Psychopharmacology, 2001, Volume: 155, Issue:3 Topics: Adult; Buspirone; Double-Blind Method; Female; Humans; Piperazines; Premenstrual Syndrome; Psychiatric Status Rating Scales; Receptors, Serotonin; Serotonin Receptor Agonists; Treatment Outcome; Triazoles	2001

Other Studies

20 other study(ies) available for nefazodone and buspirone

Article	Year
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Physical binding pocket induction for affinity prediction. Journal of medicinal chemistry, 2009, Oct-08, Volume: 52, Issue:19 Topics: Binding Sites; Ligands; Models, Molecular; Neural Networks, Computer; Peptide Fragments; Protein Binding; Receptor, Serotonin, 5-HT1A	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Experimental solubility profiling of marketed CNS drugs, exploring solubility limit of CNS discovery candidate. Bioorganic & medicinal chemistry letters, 2010, Dec-15, Volume: 20, Issue:24 Topics: Central Nervous System Agents; Drug Evaluation, Preclinical; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Solubility	2010
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Cholestasis; Drug-Related Side Effects and Adverse Reactions; Humans; Insecta; Rats; Risk Factors	2012
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Which metabolites circulate? Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:5 Topics: Humans; Metabolic Clearance Rate; Pharmaceutical Preparations	2013
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds. Pharmaceutical research, 2014, Volume: 31, Issue:4 Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation	2014
Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump. Hepatology (Baltimore, Md.), 2014, Volume: 60, Issue:3 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Chemical and Drug Induced Liver Injury; Humans; Male; Mitochondria, Liver; Rats; Rats, Sprague-Dawley; Severity of Illness Index	2014
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships. Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16 Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone	2016
Inhibition of hepatobiliary transport as a predictive method for clinical hepatotoxicity of nefazodone. Toxicological sciences : an official journal of the Society of Toxicology, 2006, Volume: 90, Issue:2 Topics: Animals; Antidepressive Agents, Second-Generation; Bile Acids and Salts; Bile Canaliculi; Biological Transport; Buspirone; Cells, Cultured; Hepatocytes; Humans; Microsomes, Liver; Piperazines; Rats; Rats, Sprague-Dawley; Trazodone; Triazoles	2006
In vitro assessment of mitochondrial dysfunction and cytotoxicity of nefazodone, trazodone, and buspirone. Toxicological sciences : an official journal of the Society of Toxicology, 2008, Volume: 103, Issue:2 Topics: Adenosine Triphosphate; Animals; Anti-Anxiety Agents; Antidepressive Agents, Second-Generation; Buspirone; Cell Line; Cell Respiration; Cell Survival; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Hepatocytes; Humans; Male; Membrane Potential, Mitochondrial; Metabolic Networks and Pathways; Mitochondria, Liver; Oxidative Phosphorylation; Oxygen Consumption; Piperazines; Rats; Rats, Sprague-Dawley; Trazodone; Triazoles	2008
How multiple medication use evolves and the importance of therapeutic trials: the slippery slide. Journal of psychiatric practice, 2008, Volume: 14, Issue:3 Topics: Anti-Anxiety Agents; Antidepressive Agents; Antipsychotic Agents; Anxiety Disorders; Asthma; Bronchodilator Agents; Buspirone; Clozapine; Comorbidity; Cooperative Behavior; Depressive Disorder, Major; Dose-Response Relationship, Drug; Drug Interactions; Drug Resistance; Drug Therapy, Combination; Humans; Long-Term Care; Patient Care Team; Piperazines; Referral and Consultation; Schizophrenia; Schizophrenic Psychology; Theophylline; Triazoles	2008
Can in vitro metabolism-dependent covalent binding data in liver microsomes distinguish hepatotoxic from nonhepatotoxic drugs? An analysis of 18 drugs with consideration of intrinsic clearance and daily dose. Chemical research in toxicology, 2008, Volume: 21, Issue:9 Topics: Acetaminophen; Binding Sites; Buspirone; Carbamazepine; Diclofenac; Diphenhydramine; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Hepatocytes; Humans; Indomethacin; Meloxicam; Microsomes, Liver; Molecular Structure; Paroxetine; Piperazines; Propranolol; Raloxifene Hydrochloride; Simvastatin; Structure-Activity Relationship; Thiazines; Thiazoles; Ticrynafen; Toxicity Tests; Triazoles	2008