Compounds > ne 58051

Page last updated: 2024-09-03

ne 58051 and zoledronic acid

ne 58051 has been researched along with zoledronic acid in 9 studies

Compound Research Comparison

Studies (ne 58051)	Trials (ne 58051)	Recent Studies (post-2010) (ne 58051)	Studies (zoledronic acid)	Trials (zoledronic acid)	Recent Studies (post-2010) (zoledronic acid)
17	0	2	4,108	620	2,610

Protein Interaction Comparison

Protein	Taxonomy	ne 58051 (IC50)	zoledronic acid (IC50)
Carbonic anhydrase 12	Homo sapiens (human)		0.316
Geranylgeranyl pyrophosphate synthase	Homo sapiens (human)		0.318
Carbonic anhydrase 2	Homo sapiens (human)		0.062
72 kDa type IV collagenase	Homo sapiens (human)		7
Farnesyl pyrophosphate synthase	Homo sapiens (human)		0.2144
Farnesyl diphosphate synthase	Escherichia coli K-12		1.1
Farnesyl pyrophosphate synthase	Leishmania donovani		0.11
Geranylgeranyl pyrophosphate synthase	Saccharomyces cerevisiae S288C		0.424
Carbonic anhydrase 9	Homo sapiens (human)		5.323
Carbonic anhydrase 14	Homo sapiens (human)		0.092

Research

Studies (9)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	6 (66.67)	29.6817
2010's	2 (22.22)	24.3611
2020's	1 (11.11)	2.80

Authors

Authors	Studies
Martin, MB; Oldfield, E; Szabo, CM	1
Bruchhaus, I; Chan, JM; Croft, SL; Flessner, RM; Ghosh, S; Kemp, RG; Kendrick, H; Kobayashi, S; Lea, CR; Lewis, JC; Loftus, TC; Meints, GA; Nozaki, T; Oldfield, E; Tovian, ZS	1
Araujo, FG; Chan, JM; Ling, Y; Moreno, SN; Odeh, S; Oldfield, E; Sahota, G	1
Hall, P; Hudock, MP; Leon, A; Liu, L; Morita, CT; Oldfield, E; Puan, KJ; Studer, D; Yang, Y; Yin, F	1
Barnett, BL; Dunford, JE; Ebetino, FH; Kavanagh, KL; Kwaasi, AA; Oppermann, U; Rogers, MJ; Russell, RG	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Cao, R; Liu, YL; Oldfield, E; Wang, Y	1
Almeida Paz, FA; Barbosa, JS; Braga, SS	1
Boissier, S; Clézardin, P; Colombel, M; Delaissé, JM; Delmas, P; Ebetino, FH; Ferreras, M; Magnetto, S; Peyruchaud, O	1

Reviews

1 review(s) available for ne 58051 and zoledronic acid

Article	Year
Bisphosphonates, Old Friends of Bones and New Trends in Clinics. Journal of medicinal chemistry, 2021, 02-11, Volume: 64, Issue:3 Topics: Animals; Bone and Bones; Bone Density Conservation Agents; Bone Diseases; Diphosphonates; Drug Compounding; Drug Delivery Systems; Humans	2021

Other Studies

8 other study(ies) available for ne 58051 and zoledronic acid

Article	Year
An investigation of bone resorption and Dictyostelium discoideum growth inhibition by bisphosphonate drugs. Journal of medicinal chemistry, 2002, Jul-04, Volume: 45, Issue:14 Topics: Alkyl and Aryl Transferases; Animals; Bone Resorption; Crystallography, X-Ray; Dictyostelium; Diphosphonates; Enzyme Inhibitors; Geranyltranstransferase; Humans; Inhibitory Concentration 50; Models, Molecular; Quantitative Structure-Activity Relationship; Rats	2002
Effects of bisphosphonates on the growth of Entamoeba histolytica and Plasmodium species in vitro and in vivo. Journal of medicinal chemistry, 2004, Jan-01, Volume: 47, Issue:1 Topics: Animals; Antimalarials; Antiprotozoal Agents; Cell Line; Cricetinae; Diphosphonates; Entamoeba histolytica; Entamoebiasis; Humans; In Vitro Techniques; Liver Abscess; Malaria; Mice; Mice, Inbred BALB C; Plasmodium berghei; Plasmodium falciparum; Structure-Activity Relationship	2004
Bisphosphonate inhibitors of Toxoplasma gondi growth: in vitro, QSAR, and in vivo investigations. Journal of medicinal chemistry, 2005, May-05, Volume: 48, Issue:9 Topics: Aldose-Ketose Isomerases; Alkyl and Aryl Transferases; Animals; Antiprotozoal Agents; Cell Line; Diphosphonates; Fosfomycin; Geranyltranstransferase; Humans; Mice; Models, Molecular; Multienzyme Complexes; Oxidoreductases; Quantitative Structure-Activity Relationship; Toxoplasma; Toxoplasmosis	2005
Isoprenoid biosynthesis as a drug target: bisphosphonate inhibition of Escherichia coli K12 growth and synergistic effects of fosmidomycin. Journal of medicinal chemistry, 2006, Dec-14, Volume: 49, Issue:25 Topics: Anti-Bacterial Agents; Cluster Analysis; Diphosphonates; Drug Synergism; Escherichia coli K12; Fosfomycin; Gene Expression; Geranyltranstransferase; Models, Molecular; Oligonucleotide Array Sequence Analysis; Quantitative Structure-Activity Relationship; Terpenes	2006
Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of human farnesyl pyrophosphate synthase. Journal of medicinal chemistry, 2008, Apr-10, Volume: 51, Issue:7 Topics: Binding Sites; Diphosphonates; Enzyme Inhibitors; Geranyltranstransferase; Humans; Models, Molecular; Molecular Structure; Nitrogen; Stereoisomerism; Structure-Activity Relationship; Time Factors	2008
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Farnesyl diphosphate synthase inhibitors with unique ligand-binding geometries. ACS medicinal chemistry letters, 2015, Mar-12, Volume: 6, Issue:3 Topics:	2015
Bisphosphonates inhibit breast and prostate carcinoma cell invasion, an early event in the formation of bone metastases. Cancer research, 2000, Jun-01, Volume: 60, Issue:11 Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Bone Neoplasms; Breast Neoplasms; Cell Adhesion; Cell Cycle; Cell Movement; Clodronic Acid; Collagen; Diphosphonates; Dose-Response Relationship, Drug; Drug Combinations; Flow Cytometry; Fluorometry; Humans; Ibandronic Acid; Imidazoles; Laminin; Male; Matrix Metalloproteinases; Neoplasm Invasiveness; Neoplasm Metastasis; Paclitaxel; Prostatic Neoplasms; Proteoglycans; Pyridines; Pyridinium Compounds; Tumor Cells, Cultured; Zinc; Zoledronic Acid	2000