Compounds > naproxen glucuronide
Page last updated: 2024-09-05

naproxen glucuronide and naproxen

naproxen glucuronide has been researched along with naproxen in 9 studies

Compound Research Comparison

Studies
(naproxen glucuronide)		Trials
(naproxen glucuronide)		Recent Studies (post-2010)
(naproxen glucuronide)		Studies
(naproxen)		Trials
(naproxen)		Recent Studies (post-2010) (naproxen)
10024,5511,0571,429

Protein Interaction Comparison

ProteinTaxonomynaproxen glucuronide (IC50)naproxen (IC50)
Prostaglandin G/H synthase 1Ovis aries (sheep)1.1642
Hormone-sensitive lipaseRattus norvegicus (Norway rat)1.2
Prostaglandin G/H synthase 1Homo sapiens (human)4.0203
Prostaglandin G/H synthase 2Homo sapiens (human)3.8725
Prostaglandin G/H synthase 2 Rattus norvegicus (Norway rat)0.06
Aldo-keto reductase family 1 member C3Homo sapiens (human)0.5867
Aldo-keto reductase family 1 member C2 Homo sapiens (human)1.26
Prostaglandin G/H synthase 2Ovis aries (sheep)3.36
Solute carrier family 22 member 6Homo sapiens (human)5.8
Prostaglandin G/H synthase 1 Rattus norvegicus (Norway rat)0.06

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's8 (88.89)29.6817
2010's1 (11.11)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fujiwara, R; Koga, T; Nakajima, M; Yokoi, T1
Aster, R; Bougie, D1
Corcoran, O; Hansen, SH; Mortensen, RW; Nicholson, JK; Troke, J1
Hansen, SH; Mortensen, RW; Sidelmann, UG; Tjørnelund, J1
Bjørnsdottir, I; Honoré Hansen, S; Olsen, J; Tjørnelund, J1
Aresta, A; Palmisano, F; Zambonin, CG1
Aresta, A; Carbonara, T; Palmisano, F; Zambonin, CG1
Brennan, JS; Gaganis, P; Knights, KM; Miners, JO; Thomas, A1
Obach, RS1

Other Studies

9 other study(ies) available for naproxen glucuronide and naproxen

ArticleYear
Toxicological evaluation of acyl glucuronides of nonsteroidal anti-inflammatory drugs using human embryonic kidney 293 cells stably expressing human UDP-glucuronosyltransferase and human hepatocytes.
    Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Camphanes; Comet Assay; DNA Damage; Glucuronides; Glucuronosyltransferase; HEK293 Cells; Hepatocytes; Humans; Kidney

2011
Immune thrombocytopenia resulting from sensitivity to metabolites of naproxen and acetaminophen.
    Blood, 2001, Jun-15, Volume: 97, Issue:12

    Topics: Acetaminophen; Adult; Aged; Antibodies; Blood Platelets; Female; Glucuronides; Humans; Male; Middle Aged; Naproxen; Platelet Glycoprotein GPIIb-IIIa Complex; Purpura, Thrombocytopenic, Idiopathic

2001
HPLC/1H NMR spectroscopic studies of the reactive alpha-1-O-acyl isomer formed during acyl migration of S-naproxen beta-1-O-acyl glucuronide.
    Chemical research in toxicology, 2001, Volume: 14, Issue:10

    Topics: Acylation; Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High Pressure Liquid; Glucuronides; Isomerism; Kinetics; Magnetic Resonance Spectroscopy; Mass Spectrometry; Naproxen

2001
Stereospecific pH-dependent degradation kinetics of R- and S-naproxen-beta-l-O-acyl-glucuronide.
    Chirality, 2002, May-05, Volume: 14, Issue:4

    Topics: Animals; Chromatography, High Pressure Liquid; Drug Stability; Female; Glucuronides; Hydrogen-Ion Concentration; In Vitro Techniques; Ketoprofen; Kinetics; Microsomes, Liver; Naproxen; Stereoisomerism; Swine

2002
Chemical reactivity of the naproxen acyl glucuronide and the naproxen coenzyme A thioester towards bionucleophiles.
    Journal of pharmaceutical and biomedical analysis, 2002, Jun-20, Volume: 29, Issue:1-2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Coenzyme A; Drug Interactions; Glucuronides; Glutathione; Humans; Naproxen

2002
Determination of naproxen in human urine by solid-phase microextraction coupled to liquid chromatography.
    Journal of pharmaceutical and biomedical analysis, 2005, Sep-15, Volume: 39, Issue:3-4

    Topics: Adsorption; Anti-Inflammatory Agents, Non-Steroidal; Chemistry, Pharmaceutical; Chromatography; Chromatography, Liquid; Drug Industry; Glucuronides; Humans; Hydrogen-Ion Concentration; Hydrolysis; Models, Chemical; Naproxen; Salts; Spectrophotometry, Ultraviolet; Temperature; Time Factors; Ultraviolet Rays

2005
Profiling urinary metabolites of naproxen by liquid chromatography-electrospray mass spectrometry.
    Journal of pharmaceutical and biomedical analysis, 2006, Jun-16, Volume: 41, Issue:4

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Chromatography, Liquid; Glucuronides; Humans; Naproxen; Spectrometry, Mass, Electrospray Ionization

2006
Human renal cortical and medullary UDP-glucuronosyltransferases (UGTs): immunohistochemical localization of UGT2B7 and UGT1A enzymes and kinetic characterization of S-naproxen glucuronidation.
    The Journal of pharmacology and experimental therapeutics, 2007, Volume: 323, Issue:2

    Topics: Glucuronides; Glucuronosyltransferase; Humans; Immunohistochemistry; Kidney Cortex; Kidney Medulla; Kinetics; Male; Naproxen

2007
Glycerolysis of acyl glucuronides as an artifact of in vitro drug metabolism incubations.
    Drug metabolism and disposition: the biological fate of chemicals, 2009, Volume: 37, Issue:8

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Artifacts; Biological Assay; Biotransformation; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Diclofenac; Glucuronates; Glucuronides; Glycerol; Humans; In Vitro Techniques; Mass Spectrometry; Mefenamic Acid; Microsomes, Liver; Naproxen; Propionates; Tolmetin; Uridine Diphosphate Glucuronic Acid

2009