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naphthoxylactic acid and propranolol

naphthoxylactic acid has been researched along with propranolol in 15 studies

Compound Research Comparison

Studies
(naphthoxylactic acid)
Trials
(naphthoxylactic acid)
Recent Studies (post-2010)
(naphthoxylactic acid)
Studies
(propranolol)
Trials
(propranolol)
Recent Studies (post-2010) (propranolol)
162033,3103,4063,218

Protein Interaction Comparison

ProteinTaxonomynaphthoxylactic acid (IC50)propranolol (IC50)
Beta-1 adrenergic receptor Cavia porcellus (domestic guinea pig)0.0347
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)0.0288
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)2.294
Cytochrome P450 1A2Homo sapiens (human)4
Beta-2 adrenergic receptorHomo sapiens (human)0.0114
Beta-1 adrenergic receptorHomo sapiens (human)0.0575
5-hydroxytryptamine receptor 1AHomo sapiens (human)3.9811
Beta-2 adrenergic receptorRattus norvegicus (Norway rat)0.012
Cytochrome P450 2D6Homo sapiens (human)2.9706
Beta-3 adrenergic receptorHomo sapiens (human)0.0493
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)0.0288
Beta-1 adrenergic receptorRattus norvegicus (Norway rat)0.012
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)0.0288
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)0.0288
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)0.0827
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)0.0288
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)0.0288
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)0.0288
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)0.0288
Beta-3 adrenergic receptorRattus norvegicus (Norway rat)0.012
5-hydroxytryptamine receptor 2AHomo sapiens (human)1.466
5-hydroxytryptamine receptor 2CHomo sapiens (human)2.294
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)0.0288
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)0.0288
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)0.243
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)0.0288
Sodium-dependent serotonin transporterHomo sapiens (human)0.38
5-hydroxytryptamine receptor 2BHomo sapiens (human)0.342
5-hydroxytryptamine receptor 6Homo sapiens (human)3.065
Beta-2 adrenergic receptorCanis lupus familiaris (dog)0.017
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)0.0288
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)0.0288
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)0.0288
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)2.828
Sodium channel protein type 5 subunit alphaHomo sapiens (human)2.1
Sodium/bile acid cotransporterHomo sapiens (human)5.5
Beta-2 adrenergic receptorCavia porcellus (domestic guinea pig)0.0288
GABA theta subunitRattus norvegicus (Norway rat)0.0288
Sigma non-opioid intracellular receptor 1Homo sapiens (human)2.87
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)0.0288

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19908 (53.33)18.7374
1990's4 (26.67)18.2507
2000's3 (20.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hayes, A; Pritchard, F; Schneck, D1
Conradi, EC; Easterling, DE; Gaffney, TE; Walle, T1
Ebihara, A; Fujimura, A; Ohashi, K; Tateishi, T1
Liedholm, H; Melander, A; Wåhlin-Boll, E1
Conradi, EC; Cowart, TD; Gaffney, TE; Walle, T; Walle, UK1
Dixon, ST; Harrison, PM; McLean, AJ; Tonkin, AM1
Effeney, DJ; Lo, MW; Pond, SM; Riegelman, S; Silber, BM; Tozer, TN1
Ejima, A; Ogata, H; Takei, H1
Eadie, MJ; Hooper, WD; Livingstone, I; Smith, MT; Triggs, EJ1
Bevan, EB; Craswell, PW; Eadie, MJ; Livingstone, I; Smith, MT1
Conradi, EC; Mathur, RS; Palesch, YY; Walle, K; Walle, T1
Hata, S; Iwaki, M; Kawafuchi, R; Ogiso, T; Tanino, T1
Alañón Molina, A; Murillo Pulgarín, JA1
Fernández-López, P; García-Alvarez-Coque, MC; Murillo-Pulgarín, JA; Ruiz-Angel, MJ1
Imamura, Y; Noda, A; Noda, H; Wu, X1

Trials

2 trial(s) available for naphthoxylactic acid and propranolol

ArticleYear
The influence of diltiazem versus cimetidine on propranolol metabolism.
    Journal of clinical pharmacology, 1992, Volume: 32, Issue:12

    Topics: Adult; Chromatography, High Pressure Liquid; Cimetidine; Diltiazem; Half-Life; Humans; Lactates; Male; Premedication; Propranolol

1992
Propranolol in pregnancy three year prospective study.
    Clinical and experimental hypertension. Part B, Hypertension in pregnancy, 1983, Volume: 2, Issue:2

    Topics: Blood Pressure; Dose-Response Relationship, Drug; Female; Humans; Hypertension; Kinetics; Lactates; Methyldopa; Milk, Human; Pregnancy; Pregnancy Complications, Cardiovascular; Propranolol; Prospective Studies

1983

Other Studies

13 other study(ies) available for naphthoxylactic acid and propranolol

ArticleYear
Measurement of naphthoxylactic and naphtoxyacetic acid in human plasma following propranolol administration.
    Research communications in chemical pathology and pharmacology, 1979, Volume: 23, Issue:2

    Topics: Chromatography, High Pressure Liquid; Glycolates; Humans; Hypertension; Lactates; Naphthalenes; Propranolol; Time Factors

1979
Quantitative analysis of naphthoxylactic acid, a major metabolite of propranolol in plasma in man.
    Journal of chromatography, 1979, Mar-01, Volume: 162, Issue:3

    Topics: Chromatography, Gas; Gas Chromatography-Mass Spectrometry; Humans; Hypertension; Lactates; Propranolol

1979
Mechanisms and variations in the food effect on propranolol bioavailability.
    European journal of clinical pharmacology, 1990, Volume: 38, Issue:5

    Topics: Adult; Biological Availability; Dietary Carbohydrates; Dietary Proteins; Female; Food; Humans; Lactates; Middle Aged; Propranolol; Propylene Glycol; Propylene Glycols

1990
Selective induction of propranolol metabolism by smoking: additional effects on renal clearance of metabolites.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 241, Issue:3

    Topics: Adult; Creatinine; Half-Life; Humans; Kidney; Lactates; Male; Metabolic Clearance Rate; Propranolol; Smoking

1987
Determination of alpha-naphthoxylactic acid, a major metabolite of propranolol, in plasma by high-performance liquid chromatography.
    Journal of chromatography, 1986, Jan-10, Volume: 374, Issue:1

    Topics: Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Humans; Lactates; Propranolol; Spectrometry, Fluorescence

1986
Nonlinear formation of propranolol metabolites in dogs after portacaval transpositions.
    Journal of pharmacokinetics and biopharmaceutics, 1984, Volume: 12, Issue:4

    Topics: Animals; Dogs; Kinetics; Lactates; Liver; Male; Mathematics; Metabolic Clearance Rate; Portacaval Shunt, Surgical; Propranolol; Time Factors

1984
Determination of propranolol and its major metabolite, naphthoxylactic acid, in human plasma by high performance liquid chromatography.
    Chemical & pharmaceutical bulletin, 1983, Volume: 31, Issue:4

    Topics: Chromatography, High Pressure Liquid; Humans; Lactates; Male; Propranolol

1983
Propranolol, propranolol glucuronide, and naphthoxylactic acid in breast milk and plasma.
    Therapeutic drug monitoring, 1983, Volume: 5, Issue:1

    Topics: Female; Half-Life; Humans; Hydrogen-Ion Concentration; Lactates; Milk, Human; Pregnancy; Propranolol

1983
Propranolol metabolism in normal subjects: association with sex steroid hormones.
    Clinical pharmacology and therapeutics, 1994, Volume: 56, Issue:2

    Topics: Adult; Chromatography, High Pressure Liquid; Estradiol; Female; Humans; Lactates; Male; Metabolic Clearance Rate; Oxidation-Reduction; Propranolol; Sex Characteristics; Testosterone

1994
Effect of food on propranolol oral clearance and a possible mechanism of this food effect.
    Biological & pharmaceutical bulletin, 1994, Volume: 17, Issue:1

    Topics: Administration, Oral; Animals; Biological Availability; Cytochrome P-450 Enzyme System; Dietary Carbohydrates; Dietary Proteins; Food; Glucose; Glucuronosyltransferase; Injections, Intravenous; Lactates; Liver; Liver Circulation; Male; Propranolol; Rats; Rats, Wistar

1994
Direct determination of 1-naphthoxylactic acid in biological fluids by non-protected fluid room temperature phosphorimetry.
    Fresenius' journal of analytical chemistry, 2000, Volume: 368, Issue:5

    Topics: Adrenergic beta-Antagonists; Fluorometry; Humans; Hydrogen-Ion Concentration; Lactates; Luminescent Measurements; Propranolol; Reproducibility of Results; Sensitivity and Specificity

2000
Control of propranolol intake by direct chromatographic detection of alpha-naphthoxylactic acid in urine.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2002, Feb-15, Volume: 767, Issue:2

    Topics: Adrenergic beta-Antagonists; Chromatography, Liquid; Humans; Lactates; Propranolol; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Fluorescence

2002
Side-chain metabolism of propranolol: involvement of monoamine oxidase and mitochondrial aldehyde dehydrogenase in the metabolism of N-desisopropylpropranolol to naphthoxylactic acid in rat liver.
    Life sciences, 2002, Apr-19, Volume: 70, Issue:22

    Topics: Aldehyde Reductase; Aldehydes; Animals; Antidotes; Cell Culture Techniques; Chromatography, High Pressure Liquid; Cyanamide; Cytosol; Fomepizole; Hepatocytes; Lactates; Liver; Male; Mitochondria, Liver; Monoamine Oxidase; Oxidation-Reduction; Propranolol; Pyrazoles; Rats; Rats, Wistar; Stereoisomerism

2002