naphthoquinones has been researched along with tetrangomycin* in 1 studies
1 other study(ies) available for naphthoquinones and tetrangomycin
| Article | Year |
|---|---|
Structure-activity relationships and mechanism of action of tetragomycin derivatives as inhibitors of Staphylococcus aureus staphyloxanthin biosynthesis.
Despite the main strategy to overcome bacterial resistance has focused on the development of more potent antimicrobial agents, the evolutionary pressure caused by such drugs makes this strategy limited. Molecules that interfere with virulence factors appear as a promising alternative though, as they cause reduced selective pressure. As a matter of fact, staphyloxanthin biosynthesis inhibition (STXBI) has been pursued as promising strategy to reduce S. aureus virulence. Herein, we report the inhibitory profile of 27 tetrangomycin derivatives over staphyloxanthin production. The experimental result showed that naphthoquinone dehydro-α-lapachone (25 - EC Topics: Anti-Bacterial Agents; Benz(a)Anthracenes; Drug Resistance, Multiple, Bacterial; Naphthalenes; Naphthoquinones; Staphylococcus aureus; Structure-Activity Relationship; Virulence Factors; Xanthophylls | 2020 |