naphthoquinones has been researched along with succinimide* in 1 studies
1 other study(ies) available for naphthoquinones and succinimide
| Article | Year |
|---|---|
Synthesis of Succinimide-Containing Chromones, Naphthoquinones, and Xanthones under Rh(III) Catalysis: Evaluation of Anticancer Activity.
The weakly coordinating ketone group directed C-H functionalizations of chromones, 1,4-naphthoquinones, and xanthones with various maleimides under rhodium(III) catalysis are described. These protocols efficiently provide a range of succinimide-containing chromones, naphthoquinones, and xanthones with excellent site selectivity and functional group compatibility. All synthetic compounds were screened for in vitro anticancer activity against human breast adenocarcinoma cell lines (MCF-7). In particular, compounds 7aa and 7ca with a naphthoquinone scaffold were found to be highly cytotoxic, with an activity competitive with anticancer agent doxorubicin. Topics: Antineoplastic Agents; Carbon-13 Magnetic Resonance Spectroscopy; Catalysis; Cell Proliferation; Chromones; Drug Screening Assays, Antitumor; Humans; MCF-7 Cells; Naphthoquinones; Proton Magnetic Resonance Spectroscopy; Reactive Oxygen Species; Rhodium; Spectrometry, Mass, Electrospray Ionization; Succinimides; Xanthones | 2016 |