naphthoquinones and duclauxin

Effects of xanthomegnin and duclauxin on mitochondrial respiration, L1210 culture cells of murine leukemia and Ehrlich ascitic tumor were compared. Both compounds exhibited similarly potent uncoupling effects on the oxidative phosphorylation of mitochondria and cyto-toxicities on the culture cells, but they were not equal in the anti-tumor activity on Ehrlich ascitic tumor. Duclauxin markedly increased the life-span of mice which were i.p. inoculated with Ehrlich ascitic tumor but xanthomegnin did not exhibit such effect as duclauxin.

Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; Carcinoma, Ehrlich Tumor; Cells, Cultured; Chromones; Female; Leukemia, Experimental; Mice; Mice, Inbred ICR; Mitochondria; Naphthoquinones; Oxidative Phosphorylation; Rats; Uncoupling Agents