naphthoquinones and bonafton

Topics: Acyclovir; Adult; Antiviral Agents; Child; Child, Preschool; Female; Herpes Simplex; Humans; Infant, Newborn; Male; Naphthoquinones; Pregnancy; Ribavirin; Vidarabine; Xanthenes; Xanthones

A 5% ointment acycloguanosine was tried in the treatment of recurrent herpes simplex of the skin and genitalia in 48 patients. The treatment brought limitation of the process, relief of the symptoms, control of local manifestations and toxicity, accelerated epithelization, complete regression and disappearance of the eruption.

Topics: Acyclovir; Adult; Antiviral Agents; Female; Herpes Simplex; Humans; Male; Middle Aged; Naphthoquinones

Results of experimental study on the effect of bonafton, tebrofen, florenal and riodoxol on synthesis of virus specific proteins and RNA are presented. Selective inhibition of RNA-transcripts and respective proteins under the effect of bonafton was revealed. Florenal had a selective inhibitory effect on synthesis of virus specific proteins. Riodoxol did not inhibit synthesis of viral RNA and proteins of the influenza virus.

Topics: Antiviral Agents; Chemical Phenomena; Chemistry; Clinical Trials as Topic; Drug Evaluation, Preclinical; Fluorenes; Humans; In Vitro Techniques; Influenza A virus; Influenza, Human; Naphthoquinones; Polybrominated Biphenyls; Resorcinols; RNA, Viral; Viral Proteins

Topics: Administration, Oral; Adolescent; Adult; Aged; Child; Child, Preschool; Clinical Trials as Topic; Humans; Middle Aged; Naphthoquinones; Ointments; Skin Diseases, Infectious; Virus Diseases

Lymphotropic therapy with trental was administered to patients with chronic herpetic stomatitis. Trental was injected near the mastoid process after preinjection with lidase (total dose no more than 1 ml on each side, 6 sessions per course). The treatment normalized the immune status, clinical symptoms regressed sooner than after treatment with an antiviral agent bonafton, remissions were prolonged, and in 5 out of 18 patients no more relapses occurred.

Topics: Adjuvants, Immunologic; Adolescent; Adult; Antibody Formation; Antiviral Agents; Chronic Disease; Drug Therapy, Combination; Humans; Hyaluronoglucosaminidase; Immunity, Cellular; Immunity, Innate; Injections, Intralymphatic; Naphthoquinones; Pentoxifylline; Stomatitis, Herpetic

The shortcomings of the existing methods of perianal condyloma treatment are as follows: extensive trauma of the reflexogenic perianal region, a large diffusely bleeding surface, the risk of secondary infection and suppuration of the wounds, cicatricial deformity of the anus, prolonged treatment and its relatively radical character. To prevent complications and produce a stable remission, 12 patients were given combined treatment comprising surgical effect of CO2 laser and administration of the Soviet antiviral preparation Bohafton in the pre- and postoperative period. No recurrences of the disease were found 12 months later.

Topics: Adolescent; Adult; Anus Neoplasms; Carbon Dioxide; Condylomata Acuminata; Electrocoagulation; Humans; Laser Therapy; Male; Middle Aged; Naphthoquinones; Postoperative Care; Preoperative Care; Surgical Wound Infection; Wound Healing

It was shown for the first time that the antiviral drug bonafton administered orally to nonlinear albino mice in single doses of 5, 12.5 and 25 mg/kg induced production of interferon in the animal blood serum. The maximum interferon titer of 160-320 IU/ml was observed 18 hours after the drug administration in a dose of 12.5 mg/kg. In low doses of 5 to 12.5 mg/kg bonafton increased the nonspecific resistance of the mice to experimental viral infections when administered orally in single doses not earlier than 2 weeks prior to the contamination. The ability of the drug to stimulate the host protective forces probably plays a certain role in the mechanism of its therapeutic action in severe viral infections of man such as severe recurring ophthalmic herpes, genital herpes, Behçet's disease, Melkersson-Rosenthal syndrome and others.

Topics: Adjuvants, Immunologic; Animals; Antiviral Agents; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Immunity, Innate; Interferon Inducers; Interferons; Mice; Naphthoquinones; Time Factors; Virus Diseases