Page last updated: 2024-08-21

naphthazarin and naphthoquinones

naphthazarin has been researched along with naphthoquinones in 74 studies

Research

Studies (74)

Timeframe	Studies, this research(%)	All Research%
pre-1990	8 (10.81)	18.7374
1990's	13 (17.57)	18.2507
2000's	30 (40.54)	29.6817
2010's	17 (22.97)	24.3611
2020's	6 (8.11)	2.80

Authors

Authors	Studies
Cheng, CC; Paull, KD; Zee-Cheng, RK	1
Brunmark, A; Ollinger, K	1
Bironaité, DA; Cénas, NK; Kulys, JJ	1
Espino, PC; Sullivan, PD	1
Cadenas, E; Llopis, J; Ollinger, K	1
Boutis, L; Christianopoulou, M; Dozi-Vassiliades, J; Lialiaris, T; Mourelatos, D; Papageorgiou, A; Papageorgiou, V	1
Ikekawa, N; Lin, S; Ota, A; Sivalingam, PM; Yaginuma, N	1
Dodd, NJ; Mukherjee, T	1
Fukumoto, K; Kametani, T	1
Cenas, N; Nemeikaite, A	1
Brunk, UT; Ollinger, K	1
Bhattacharjee, AK; Gadre, SR; Pundlik, SS	1
Byung-Zun, A; Dai-Eun, S; Kyong-Up, B; Yong, K; Yong, SG	1
Latanowicz, L; Reynhardt, EC	1
Ollinger, K; Roberg, K	1
Afonskaya, NI; Cherpachenko, NM; Elyakov, GB; Lebedev, AV; Levitsky, DO; Maximov, OB; Novikov, VL; Sadretdinov, SM; Shvilkin, AV	1
Ahn, BZ; Yong, K; You, YJ; Zheng, XG	1
Ahn, BZ; Kim, Y; Sok, DE; Song, GY; You, YJ; Zheng, XG	1
Abrahamsson, N; Brunk, UT; Terman, A	1
Ollinger, K	1
Johansson, U; Ollinger, K; Roberg, K	1
Ahn, BZ; Jin, GZ; Kang, JS; Kim, HM; Zheng, XG	1
Ahn, BZ; Cho, H; Chung, JH; Kim, Y; Sok, DE; Song, GY; You, YJ; Zheng, XG	1
Ahn, BZ; Cho, H; Kim, SH; Kim, Y; Sok, DE; Song, GY; You, YJ	1
De Silva, H; Fu, Y; Kelly, TR; Sieglen, JT	1
Gao, D; Kakuma, M; Oka, S; Sakurai, H; Sugino, K	1
Roberg, K	1
Ahn, BZ; Cho, H; Kim, Y; Song, GY; You, YJ	2
Biot, C; Davioud-Charvet, E; Dessolin, J	1
Choi, DH; Choi, SH; Chun, BG; Lee, JJ; Park, MS	1
Bizani, D; Brandelli, A; Medina, LF; Riffel, A; Santos, RC; Stefani, V	1
Assimopoulou, AN; Gavalas, A; Kourounakis, AP; Kourounakis, PN; Papageorgiou, VP	1
Förlin, L; Stephensen, E; Sturve, J	1
Choi, DH; Choi, SH; Chun, BG; Kim, DH; Park, YG	1
Andrikopoulos, NK; Assimopoulou, AN; Kaliora, AC; Papapeorgiou, VP	1
Behforouz, M; Tabrizi, MZ; Tayyari, F; Tayyari, SF	1
Kim, SH; Lee, IJ; Park, EM; Park, YM; Song, GY	1
Chan, AS; Duan, ZF; Feng, GK; Gu, LQ; Huang, ZS; Li, YM; Liu, ZC; Wu, HQ; Xie, BF	1
Alegría, AE; Rivas, L; Sanchez-Cruz, P	1
Brandelli, A; Medina, LF; Stefani, V	1
Chen, YJ; Cheng, HW; Cheng, YW; Kang, JJ; Lee, CC; Lee, PJ; Li, CH	1
Johansson, AC; Norberg-Spaak, L; Roberg, K	1
Chai, CL; Elix, JA; Moore, FK	1
Cho, H; Chung, Y; Jung, JK; Kim, BH; Park, SH; Yoo, J	1
Juranić, Z; Kovacević, N; Kundaković, T; Stanojković, T	1
Bedir, E; Ganzera, M; Korkmaz, KS; Pekin, G; Senol, S; Stuppner, H	1
Choi, SH; Chun, BG; Hong, GH; Hwang, IK; Kim, DW; Lee, HH; Won, CK; Won, MH	1
Arnér, ES; Califf, LL; Davioud-Charvet, E; Dessolin, J; Kuntz, AN; Sayed, AA; Williams, DL	1
Brimble, MA; Rathwell, DC; Tsang, KY; Yang, SH	1
ROGERS, MT	1
Acharya, BR; Bhattacharyya, S; Chakrabarti, G; Choudhury, D	1
Becker, KG; Camandola, S; Greig, NH; Hunt, PR; Mattson, MP; Son, TG; Wilson, MA; Wolkow, CA; Wood, WH; Yu, QS; Zhang, Y	1
Hanif, A; Nash, JE; Perera, G; Sidorova, E; Yong-Kee, CJ	1
Heo, K; Hyun, DH; Kim, JA; Kim, ND; Lee, CG; Lee, EK; Lee, JH; Park, SJ; Son, TG; Yang, KM	1
Choi, SY; Jang, YJ; Jin, B; Lee, J; Oh, SB; Park, HR; Son, TG	1
Lozano, AM; Monnier, PP; Nash, JE; Warre, R; Yong-Kee, CJ	1
Camandola, S; Greig, NH; Kawamoto, EM; Mattson, MP; Son, TG; Yu, QS	1
Andrade, PB; Oliveira, JM; Pinho, BR; Sousa, C; Valentão, P	1
Hou, X; Qi, C; Sun, Z; Zhao, L; Zhao, P; Zuo, L	1
Cui, JH; Ding, J; Li, SS; Meng, QQ; Song, HL; Wang, RB; Xu, Y; Yang, K; Zhang, X; Zhou, W	1
Anufriev, VP; Denisenko, VA; Dragana, SV; Glazunov, VP; Pushilin, MA	1
Heo, K; Kang, HS; Kim, MY; Park, SJ; Shim, JW; Yang, K	1
Aljanadi, O; Alzoubi, K; Bissinger, R; Lang, F	1
Fang, J; Han, X; Hu, G; Li, X; Liu, R; Liu, Y; Shi, D; Yao, X; Zhang, B; Zhang, J	1
Alumkal, JJ; Bicocca, VT; Chang, BH; Chow, M; Gao, L; MacManiman, JD; Tyner, JW	1
Karcz, W; Ludynia, M; Rudnicka, M	1
Fan, C; Leavesley, D; Lim, LKP; Loh, SQ; Upton, Z; Ying Lim, KY	1
Gulati, A; Sharma, N	1
Aminin, D; Chingizova, E; Denisenko, V; Likhatskaya, G; Menchinskaya, E; Pelageev, D; Pislyagin, E; Polonik, S; Sabutski, Y	1
Bouajila, J; Bouarab, L; Cottaz, A; Degraeve, P; Jbilou, F; Joly, C; Oulahal, N	1
Błaziak, K; Jezierska, A; Klahm, S; Lüchow, A; Panek, JJ	1
Bian, Y; Chen, C; Lin, J; Liu, B; Liu, S; Liu, Z; Ma, P; Meng, Q; Yang, C; Yuan, M	1
Benfodda, Z; Duvauchelle, V; Majdi, C; Meffre, P	1

Reviews

2 review(s) available for naphthazarin and naphthoquinones

Article	Year
Syntheses of linear tetracyclic antibiotics--tetracyclines and anthracyclines. Medicinal research reviews, 1981,Spring, Volume: 1, Issue:1 Topics: Anthraquinones; Antibiotics, Antineoplastic; Chemistry; Cyclization; History, 20th Century; Hydroquinones; Methods; Naphthacenes; Naphthoquinones; Oxytetracycline; Tetracyclines; Tetrahydronaphthalenes	1981
An overview on the antibacterial properties of juglone, naphthazarin, plumbagin and lawsone derivatives and their metal complexes. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023, Volume: 162 Topics: Anti-Bacterial Agents; Bacteria; Coordination Complexes; Humans; Naphthoquinones	2023

Other Studies

72 other study(ies) available for naphthazarin and naphthoquinones

Article	Year
Some substituted naphthazarins as potential anticancer agents. Journal of medicinal chemistry, 1976, Volume: 19, Issue:2 Topics: Animals; Antineoplastic Agents; Carcinoma 256, Walker; Carcinoma, Ehrlich Tumor; Leukemia L1210; Leukemia, Experimental; Mice; Naphthoquinones; Osteosarcoma; Sarcoma 180; Sarcoma, Experimental	1976
Effect of hydroxy substituent position on 1,4-naphthoquinone toxicity to rat hepatocytes. The Journal of biological chemistry, 1991, Nov-15, Volume: 266, Issue:32 Topics: Animals; Buthionine Sulfoximine; Carmustine; Cell Survival; Dicumarol; Glutathione; Liver; Male; Methionine Sulfoximine; Mitochondria, Liver; Molecular Structure; Naphthoquinones; Oxidation-Reduction; Oxygen Consumption; Rats; Rats, Inbred Strains; Structure-Activity Relationship	1991
On the mechanism of rotenone-insensitive reduction of quinones by mitochondrial NADH:ubiquinone reductase. The high affinity binding of NAD+ and NADH to the reduced enzyme form. FEBS letters, 1991, Jun-24, Volume: 284, Issue:2 Topics: Animals; Binding, Competitive; Cattle; Mitochondria, Heart; NAD; NAD(P)H Dehydrogenase (Quinone); Naphthoquinones; Oxidation-Reduction; Quinone Reductases; Rotenone	1991
In vitro inhibition of the metabolism and mutagenicity of benzo(a)pyrene and benzo(a)pyrene-7,8-dihydrodiol by naphthazarin and other naphthol derivatives. Biochemical and biophysical research communications, 1987, Feb-13, Volume: 142, Issue:3 Topics: Benzo(a)pyrene; Dicumarol; Dihydroxydihydrobenzopyrenes; Microsomes; Mutagenicity Tests; Mutagens; NAD(P)H Dehydrogenase (Quinone); NADP; NADPH-Ferrihemoprotein Reductase; Naphthols; Naphthoquinones; Oxidation-Reduction; Oxygen Consumption; Quinone Reductases	1987
Study of the redox properties of naphthazarin (5,8-dihydroxy-1,4-naphthoquinone) and its glutathionyl conjugate in biological reactions: one- and two-electron enzymatic reduction. Archives of biochemistry and biophysics, 1989, Volume: 275, Issue:2 Topics: Animals; Antibiotics, Antineoplastic; Electron Transport; Fish Venoms; Glutathione; Kinetics; Liver; NADP; NADPH-Ferrihemoprotein Reductase; Naphthoquinones; Oxidation-Reduction; Quinone Reductases; Rats	1989
Comparative study on cytogenetic effects by diplatinum complexes of the ligands of naphthazarine and squaric acid in human lymphocytes. The Journal of pharmacology and experimental therapeutics, 1989, Volume: 251, Issue:1 Topics: Adolescent; Adult; Antineoplastic Agents; Cell Division; Cisplatin; Cyclobutanes; Humans; In Vitro Techniques; Lymphocytes; Male; Naphthoquinones; Organoplatinum Compounds; Sister Chromatid Exchange	1989
Isolation of naphthazarin from walnut "onigurumi" and its inhibitory action on oxidative phosphorylation in mitochondria. Toxicon : official journal of the International Society on Toxinology, 1973, Volume: 11, Issue:3 Topics: Adenosine Triphosphate; Animals; Calcium; Chromatography; Dose-Response Relationship, Drug; Fishes; Hydrogen; In Vitro Techniques; Magnetic Resonance Spectroscopy; Mitochondria, Liver; Naphthols; Naphthoquinones; Oxidative Phosphorylation; Oxygen Consumption; Phosphorus Isotopes; Plants; Rats; Spectrophotometry, Infrared; Toxins, Biological	1973
Free radical formation from anthracycline antitumour agents and model systems--I. Model naphthoquinones and anthraquinones. Biochemical pharmacology, 1984, Feb-01, Volume: 33, Issue:3 Topics: Anthraquinones; Antibiotics, Antineoplastic; Electron Spin Resonance Spectroscopy; Free Radicals; Naphthacenes; Naphthoquinones	1984
The changes of prooxidant and antioxidant enzyme activities in bovine leukemia virus-transformed cells. Their influence on quinone cytotoxicity. FEBS letters, 1993, Jul-12, Volume: 326, Issue:1-3 Topics: Animals; Benzoquinones; Cattle; Cell Line, Transformed; Cell Survival; Cell Transformation, Viral; Embryo, Mammalian; Ferricyanides; Fibroblasts; Kidney; Leukemia Virus, Bovine; Multienzyme Complexes; NAD(P)H Dehydrogenase (Quinone); NADH Dehydrogenase; NADH, NADPH Oxidoreductases; NADPH Oxidases; NADPH-Ferrihemoprotein Reductase; Naphthoquinones; Oxidation-Reduction; Quinones; Sheep	1993
Cellular injury induced by oxidative stress is mediated through lysosomal damage. Free radical biology & medicine, 1995, Volume: 19, Issue:5 Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Antioxidants; Calcium; Cell Survival; Cells, Cultured; Cytochalasin B; Cytosol; Deferoxamine; Endocytosis; Glutathione; Iron Chelating Agents; Kinetics; Liver; Lysosomes; Male; Monensin; Naphthoquinones; Oxidative Stress; Phenylenediamines; Rats; Rats, Wistar; Time Factors	1995
Conformational and electrostatic properties of naphthazarin, juglone, and naphthoquinone: an ab initio theoretical study. Cancer investigation, 1997, Volume: 15, Issue:6 Topics: Antineoplastic Agents; Doxorubicin; Models, Chemical; Naphthoquinones; Protein Conformation; Static Electricity; Structure-Activity Relationship	1997
2-Substituted naphthazarins; synthesis and antitumor activity. Archiv der Pharmazie, 1997, Volume: 330, Issue:12 Topics: Animals; Antineoplastic Agents; Mice; Mice, Inbred ICR; Naphthoquinones; Structure-Activity Relationship	1997
1H and 2H NMR relaxation in hydrogen-bonded solids due to a complex motion: classical jumps over a barrier and incoherent tunneling. Journal of magnetic resonance (San Diego, Calif. : 1997), 1998, Volume: 130, Issue:2 Topics: Deuterium; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Models, Chemical; Naphthoquinones; Protons; Spin Labels; Temperature; Thermodynamics	1998
Oxidative stress causes relocation of the lysosomal enzyme cathepsin D with ensuing apoptosis in neonatal rat cardiomyocytes. The American journal of pathology, 1998, Volume: 152, Issue:5 Topics: Adenosine Triphosphate; Animals; Apoptosis; Cathepsin D; Cells, Cultured; Female; Fluorescent Antibody Technique, Indirect; Heart; Hydrogen-Ion Concentration; L-Lactate Dehydrogenase; Lysosomes; Male; Microscopy, Immunoelectron; Myocardium; Naphthoquinones; Oxidative Stress; Rats; Rats, Sprague-Dawley; Vitamin E	1998
Synthesis of some hydroxynaphthazarins and their cardioprotective effects under ischemia-reperfusion in vivo. Bioorganic & medicinal chemistry letters, 1998, Mar-17, Volume: 8, Issue:6 Topics: Animals; Hydroxylation; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Models, Chemical; Myocardial Infarction; Naphthoquinones; Nitroglycerin; Rabbits; Vasodilator Agents; Verapamil	1998
Naphthazarin derivatives: synthesis, cytotoxic mechanism and evaluation of antitumor activity. Archives of pharmacal research, 1998, Volume: 21, Issue:5 Topics: Acetylation; Animals; Antineoplastic Agents, Phytogenic; Cell Survival; Enzyme Inhibitors; Glutathione; Leukemia L1210; Male; Mice; Mice, Inbred ICR; Naphthoquinones; Oxidation-Reduction; Sarcoma 180; Topoisomerase I Inhibitors	1998
Naphthazarin derivatives (II): formation of glutathione conjugate, inhibition of DNA topoisomerase-I and cytotoxicity. Bioorganic & medicinal chemistry letters, 1999, Aug-16, Volume: 9, Issue:16 Topics: Animals; Antineoplastic Agents; Enzyme Inhibitors; Glutathione; Leukemia L1210; Naphthoquinones; Structure-Activity Relationship; Topoisomerase I Inhibitors; Tumor Cells, Cultured	1999
Ceroid/lipofuscin-loaded human fibroblasts show increased susceptibility to oxidative stress. Experimental gerontology, 1999, Volume: 34, Issue:6 Topics: Acridine Orange; Cathepsin D; Cell Compartmentation; Cell Line; Ceroid; Fibroblasts; Humans; Lipofuscin; Lysosomes; Naphthoquinones; Oxidants; Oxidative Stress	1999
Inhibition of cathepsin D prevents free-radical-induced apoptosis in rat cardiomyocytes. Archives of biochemistry and biophysics, 2000, Jan-15, Volume: 373, Issue:2 Topics: Animals; Apoptosis; Caspase 3; Caspases; Cathepsin D; Cells, Cultured; Enzyme Activation; Female; Fluorescent Antibody Technique; Free Radicals; Heart; In Situ Nick-End Labeling; Male; Myocardium; Naphthoquinones; Oxidative Stress; Pepstatins; Rats; Rats, Sprague-Dawley; Time Factors	2000
Lysosomal release of cathepsin D precedes relocation of cytochrome c and loss of mitochondrial transmembrane potential during apoptosis induced by oxidative stress. Free radical biology & medicine, 1999, Volume: 27, Issue:11-12 Topics: Apoptosis; Cathepsin D; Cell Line; Cytochrome c Group; Fibroblasts; Flow Cytometry; Fluorescent Antibody Technique; Humans; Lysosomes; Male; Membrane Potentials; Microscopy, Electron; Mitochondria; Naphthoquinones; Oxidative Stress; Pepstatins; Protease Inhibitors	1999
Naphthazarin derivatives (V): formation of glutathione conjugate and cytotoxic activity of 2-or 6-substituted 5,8-dimethoxy-1,4-napthoquinones in the presence of glutathione-S-transferase, in rat liver S-9 fraction and mouse liver perfusate. Archives of pharmacal research, 2000, Volume: 23, Issue:1 Topics: Animals; Antineoplastic Agents; Glutathione; Glutathione Transferase; Liver; Mice; Microsomes, Liver; Naphthoquinones; Perfusion; Rats; Structure-Activity Relationship	2000
Naphthazarin derivatives (IV): synthesis, inhibition of DNA topoisomerase I and cytotoxicity of 2- or 6-acyl-5,8-dimethoxy-1, 4-naphthoquinones. European journal of medicinal chemistry, 2000, Volume: 35, Issue:3 Topics: Animals; Antineoplastic Agents; Enzyme Inhibitors; In Vitro Techniques; Leukemia L1210; Mice; Microsomes, Liver; Naphthoquinones; Oxidation-Reduction; Oxygen Consumption; Structure-Activity Relationship; Topoisomerase I Inhibitors; Tumor Cells, Cultured	2000
Naphthazarin derivatives (VI): synthesis, inhibitory effect on DNA topoisomerase-I and antiproliferative activity of 2- or 6-(1-oxyiminoalkyl)-5,8-dimethoxy-1,4-naphthoquinones. Archiv der Pharmazie, 2000, Volume: 333, Issue:4 Topics: Animals; Antineoplastic Agents; Inhibitory Concentration 50; Leukemia L1210; Mice; Naphthoquinones; Structure-Activity Relationship; Topoisomerase I Inhibitors; Tumor Cells, Cultured	2000
Synthesis of an orange anthrathiophene pigment isolated from a Japanese bryozoan. Organic letters, 2000, Jul-27, Volume: 2, Issue:15 Topics: Animals; Anthraquinones; Bryozoa; Japan; Naphthoquinones; Pigments, Biological; Thiophenes	2000
Reaction of beta-alkannin (shikonin) with reactive oxygen species: detection of beta-alkannin free radicals. Bioorganic & medicinal chemistry, 2000, Volume: 8, Issue:11 Topics: Acetonitriles; Anti-Inflammatory Agents, Non-Steroidal; Deuterium Oxide; Electron Spin Resonance Spectroscopy; Free Radical Scavengers; Free Radicals; Lipid Peroxidation; Molecular Structure; Naphthoquinones; Peroxides; Plants, Medicinal; Potentiometry; Reactive Oxygen Species; Spin Trapping	2000
Relocalization of cathepsin D and cytochrome c early in apoptosis revealed by immunoelectron microscopy. Laboratory investigation; a journal of technical methods and pathology, 2001, Volume: 81, Issue:2 Topics: Animals; Animals, Newborn; Apoptosis; Cathepsin D; Cells, Cultured; Cytochrome c Group; Fish Venoms; Intracellular Membranes; Lysosomes; Membrane Potentials; Microscopy, Immunoelectron; Mitochondria, Heart; Myocardium; Naphthoquinones; Oxidative Stress; Rats	2001
Naphthazarin derivatives (VII): antitumor action against ICR mice bearing ascitic S-180 cells. Archives of pharmacal research, 2001, Volume: 24, Issue:1 Topics: Animals; Antineoplastic Agents; Drug Screening Assays, Antitumor; Male; Mice; Mice, Inbred ICR; Naphthoquinones; Sarcoma 180; Tumor Cells, Cultured	2001
Naphthazarin derivatives (VII): antitumor action against ICR mice bearing ascitic S-180 cells. Archives of pharmacal research, 2001, Volume: 24, Issue:3 Topics: Animals; Antineoplastic Agents; Indicators and Reagents; Injections, Intraperitoneal; Male; Mice; Mice, Inbred ICR; Naphthoquinones; Neoplasm Transplantation; Sarcoma 180; Structure-Activity Relationship; Survival Analysis	2001
Bromination studies of the 2,3-dimethylnaphthazarin core allowing easy access to naphthazarin derivatives. The Journal of organic chemistry, 2001, Aug-10, Volume: 66, Issue:16 Topics: Anti-Inflammatory Agents; Antiparasitic Agents; Bromine; Naphthoquinones	2001
Imidazoline drugs stabilize lysosomes and inhibit oxidative cytotoxicity in astrocytes. Free radical biology & medicine, 2002, Mar-01, Volume: 32, Issue:5 Topics: Acridine Orange; Adrenergic alpha-Antagonists; Animals; Animals, Newborn; Antineoplastic Agents; Apoptosis; Astrocytes; Cathepsin D; Cell Division; Cell Line; Cerebral Cortex; Cytochrome c Group; Fish Venoms; Guanabenz; Guanfacine; HIV Protease Inhibitors; Idazoxan; Imidazoles; Indoles; Isoindoles; L-Lactate Dehydrogenase; Ligands; Lysosomes; Membrane Potentials; Mitochondria; Naphthoquinones; Neuroglia; Oxidation-Reduction; Pepstatins; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptors, Drug	2002
In vitro antimicrobial activity of a new series of 1,4-naphthoquinones. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2002, Volume: 35, Issue:7 Topics: Animals; Anti-Bacterial Agents; Drug Resistance, Microbial; Gram-Negative Bacteria; Gram-Positive Bacteria; Listeria; Microbial Sensitivity Tests; Naphthoquinones; Sheep; Staphylococcus aureus; Streptococcus	2002
Alkannin and shikonin: effect on free radical processes and on inflammation - a preliminary pharmacochemical investigation. Archiv der Pharmazie, 2002, Volume: 335, Issue:6 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dimethyl Sulfoxide; Edema; Female; Free Radical Scavengers; Freund's Adjuvant; Lipid Peroxidation; Naphthoquinones; Rats; Rats, Inbred F344	2002
Effects of redox cycling compounds on glutathione content and activity of glutathione-related enzymes in rainbow trout liver. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 2002, Volume: 133, Issue:3 Topics: Animals; beta-Naphthoflavone; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Glutathione Transferase; Liver; Naphthoquinones; Oncorhynchus mykiss; Oxidation-Reduction; Oxidative Stress; Paraquat; Reactive Oxygen Species; Reducing Agents; Vitamin K 3	2002
Protective effects of rilmenidine and AGN 192403 on oxidative cytotoxicity and mitochondrial inhibitor-induced cytotoxicity in astrocytes. Free radical biology & medicine, 2002, Nov-15, Volume: 33, Issue:10 Topics: Animals; Animals, Newborn; Antihypertensive Agents; Antimycin A; Astrocytes; Bridged Bicyclo Compounds; Caspase 9; Caspases; Cell Death; Cytochrome c Group; Dose-Response Relationship, Drug; Free Radicals; Heptanes; Lysosomes; Membrane Potentials; Mitochondria; Models, Chemical; Naphthoquinones; Neuroglia; Oxazoles; Oxidative Stress; Oxygen; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Rilmenidine; Time Factors	2002
Biological activity of some naturally occurring resins, gums and pigments against in vitro LDL oxidation. Phytotherapy research : PTR, 2003, Volume: 17, Issue:5 Topics: Cholesterol, LDL; Dose-Response Relationship, Drug; Gum Arabic; Humans; Karaya Gum; Mastic Resin; Naphthoquinones; Oils, Volatile; Oxidation-Reduction; Pigments, Biological; Pistacia; Plant Extracts; Resins, Plant; Structure-Activity Relationship; Triterpenes	2003
Fourier transform infrared and Raman spectra, vibrational assignment and density functional theory calculations of naphthazarin. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2004, Volume: 60, Issue:1-2 Topics: Hydrogen Bonding; Ketones; Magnetic Resonance Spectroscopy; Models, Chemical; Models, Theoretical; Naphthoquinones; Normal Distribution; Protons; Spectrophotometry; Spectrophotometry, Infrared; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman	2004
Inhibitory effect of a naphthazarin derivative, S64, on heat shock factor (Hsf) activation and glutathione status following hypoxia. Cell biology and toxicology, 2003, Volume: 19, Issue:5 Topics: Animals; Antineoplastic Agents; Blotting, Western; Cell Line, Tumor; Cell Nucleus; DNA; Glutamate-Cysteine Ligase; Glutathione; HSP70 Heat-Shock Proteins; Hypoxia; Mice; Naphthoquinones; Protein Binding; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA; Time Factors	2003
Synthesis and cytotoxicity study of alkannin derivatives. European journal of medicinal chemistry, 2004, Volume: 39, Issue:9 Topics: Boraginaceae; Cell Line, Tumor; Cell Survival; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Naphthoquinones; Structure-Activity Relationship	2004
Alkaline-earth cations enhance ortho-quinone-catalyzed ascorbate oxidation. Free radical biology & medicine, 2004, Nov-15, Volume: 37, Issue:10 Topics: Ascorbic Acid; Electron Spin Resonance Spectroscopy; Metals, Alkaline Earth; Naphthoquinones; Oxidation-Reduction; Quinones	2004
Use of 1,4-naphthoquinones for control of Erwinia carotovora. Canadian journal of microbiology, 2004, Volume: 50, Issue:11 Topics: Anti-Bacterial Agents; Microbial Sensitivity Tests; Naphthoquinones; Pectobacterium carotovorum; Plant Diseases; Solanum tuberosum	2004
Naphthazarin and methylnaphthazarin cause vascular dysfunction by impairment of endothelium-derived nitric oxide and increased superoxide anion generation. Toxicology in vitro : an international journal published in association with BIBRA, 2006, Volume: 20, Issue:1 Topics: Acetylcholine; Animals; Aorta, Thoracic; Cells, Cultured; Endothelial Cells; Endothelium, Vascular; Humans; In Vitro Techniques; Naphthoquinones; Nitric Oxide; Nitric Oxide Synthase; Phenylephrine; Rats; Rats, Wistar; Superoxides; Vasoconstriction; Vasodilation	2006
Role of lysosomal cathepsins in naphthazarin- and Fas-induced apoptosis in oral squamous cell carcinoma cells. Acta oto-laryngologica, 2006, Volume: 126, Issue:1 Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Carcinoma, Squamous Cell; Caspases; Cathepsins; Cell Line, Tumor; Cysteine Proteinase Inhibitors; Cytosol; Dipeptides; Enzyme-Linked Immunosorbent Assay; fas Receptor; Fluorescent Antibody Technique; Humans; Intracellular Membranes; Ketones; Lysosomes; Mouth Neoplasms; Multivariate Analysis; Naphthoquinones; Signal Transduction	2006
Concise formal total synthesis of hybocarpone and related naturally occurring naphthazarins. The Journal of organic chemistry, 2006, Feb-03, Volume: 71, Issue:3 Topics: Alkylation; Lichens; Molecular Structure; Naphthalenes; Naphthoquinones; Phenylacetates	2006
Synthesis and evaluation of antitumor activity of novel 1,4-naphthoquinone derivatives (IV). Archives of pharmacal research, 2006, Volume: 29, Issue:2 Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Male; Mice; Mice, Inbred ICR; Naphthoquinones; Neoplasm Transplantation; Sarcoma 180; Structure-Activity Relationship	2006
Cytotoxicity in vitro of naphthazarin derivatives from Onosma arenaria. Phytotherapy research : PTR, 2006, Volume: 20, Issue:7 Topics: Adenocarcinoma; Antineoplastic Agents, Phytogenic; Boraginaceae; Cell Line, Tumor; Female; Humans; Inhibitory Concentration 50; Leukemia; Leukocytes, Mononuclear; Naphthoquinones; Phytohemagglutinins; Phytotherapy; Plant Roots; Uterine Cervical Neoplasms	2006
Determination of naphthazarin derivatives in endemic Turkish Alkanna species by reversed phase high performance liquid chromatography. Planta medica, 2007, Volume: 73, Issue:3 Topics: Boraginaceae; Chromatography, High Pressure Liquid; Chromatography, Liquid; Humans; Mass Spectrometry; Medicine, Traditional; Naphthoquinones; Phytotherapy; Plant Extracts; Turkey	2007
Effect of colloidal silver against the cytotoxicity of hydrogen peroxide and naphthazarin on primary cultured cortical astrocytes. The International journal of neuroscience, 2007, Volume: 117, Issue:3 Topics: Animals; Animals, Newborn; Astrocytes; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Drug Interactions; Hydrogen Peroxide; L-Lactate Dehydrogenase; Naphthoquinones; Oxidants; Rats; Rats, Sprague-Dawley; Reactive Nitrogen Species; Silver Compounds; Tetrazolium Salts; Thiazoles	2007
Thioredoxin glutathione reductase from Schistosoma mansoni: an essential parasite enzyme and a key drug target. PLoS medicine, 2007, Volume: 4, Issue:6 Topics: Animals; Auranofin; Drug Design; Female; Kinetics; Male; Mice; Mice, Inbred C57BL; Multienzyme Complexes; NADH, NADPH Oxidoreductases; Naphthoquinones; Oxidation-Reduction; Recombinant Proteins; RNA Interference; Schistosoma mansoni; Schistosomiasis mansoni; Schistosomicides; Signal Transduction	2007
An efficient formal synthesis of the human telomerase inhibitor (+/-)-gamma-rubromycin. Angewandte Chemie (International ed. in English), 2009, Volume: 48, Issue:43 Topics: Anti-Bacterial Agents; Benzene Derivatives; Crystallography, X-Ray; Enzyme Inhibitors; Humans; Isocoumarins; Molecular Conformation; Naphthoquinones; Quinones; Telomerase	2009
The magnetic anisotropy of coronene, naphthazarin, and other crystals. Journal of the American Chemical Society, 1947, Volume: 69, Issue:6 Topics: Anisotropy; Crystallization; Magnetic Phenomena; Magnetics; Naphthoquinones; Polycyclic Compounds	1947
The microtubule depolymerizing agent naphthazarin induces both apoptosis and autophagy in A549 lung cancer cells. Apoptosis : an international journal on programmed cell death, 2011, Volume: 16, Issue:9 Topics: Apoptosis; Autophagy; bcl-2-Associated X Protein; Carcinoma, Non-Small-Cell Lung; Caspase 3; Cell Cycle; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Survival; Cell-Free System; Dose-Response Relationship, Drug; Flow Cytometry; Humans; Immunoprecipitation; Inhibitory Concentration 50; Microscopy, Confocal; Microtubules; Mitochondria; Mitochondrial Proteins; Mitotic Index; Molecular Structure; Naphthoquinones; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-akt; Signal Transduction; Tubulin; Tumor Suppressor Protein p53	2011
Extension of lifespan in C. elegans by naphthoquinones that act through stress hormesis mechanisms. PloS one, 2011, Volume: 6, Issue:7 Topics: Aging; Animals; Biosensing Techniques; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Gene Expression Regulation; Genes, Reporter; Green Fluorescent Proteins; Hep G2 Cells; Humans; Longevity; Mutation; Naphthoquinones; Stress, Physiological; Survival Analysis; Tetrahydronaphthalenes; Toxins, Biological; Transcription Factors; Transcription, Genetic; Vitamin K 3	2011
Mitochondrial dysfunction precedes other sub-cellular abnormalities in an in vitro model linked with cell death in Parkinson's disease. Neurotoxicity research, 2012, Volume: 21, Issue:2 Topics: Cell Death; Cell Line, Tumor; Humans; Lysosomes; Mitochondria; Naphthoquinones; Neurons; Parkinson Disease, Secondary; Proteasome Endopeptidase Complex; Rotenone; Time Factors; Ubiquitin	2012
Novel anti-cancer role of naphthazarin in human gastric cancer cells. International journal of oncology, 2012, Volume: 40, Issue:1 Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Glutathione; Humans; Naphthoquinones; Oxidative Stress; Reactive Oxygen Species; Stomach Neoplasms	2012
Naphthazarin has a protective effect on the 1-methyl-4-phenyl-1,2,3,4-tetrahydropyridine-induced Parkinson's disease model. Journal of neuroscience research, 2012, Volume: 90, Issue:9 Topics: Animals; Astrocytes; Blotting, Western; Cell Survival; Disease Models, Animal; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Naphthoquinones; Neurons; Neuroprotective Agents; Parkinsonian Disorders	2012
Evidence for synergism between cell death mechanisms in a cellular model of neurodegeneration in Parkinson's disease. Neurotoxicity research, 2012, Volume: 22, Issue:4 Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Survival; Dopamine; Dose-Response Relationship, Drug; Drug Synergism; Humans; Lysosomes; Mitochondria; Naphthoquinones; Neuroblastoma; Neurotoxins; Proteasome Endopeptidase Complex; Rotenone	2012
Naphthazarin protects against glutamate-induced neuronal death via activation of the Nrf2/ARE pathway. Biochemical and biophysical research communications, 2013, Apr-19, Volume: 433, Issue:4 Topics: Animals; Astrocytes; Carrier Proteins; Cell Death; Cell Survival; Dose-Response Relationship, Drug; Genes, Reporter; Glutamic Acid; Hep G2 Cells; Humans; Microfilament Proteins; Naphthoquinones; Neurons; Neuroprotective Agents; NF-E2-Related Factor 2; Primary Cell Culture; Proteolysis; Rats; Rats, Sprague-Dawley	2013
Modulation of basophils' degranulation and allergy-related enzymes by monomeric and dimeric naphthoquinones. PloS one, 2014, Volume: 9, Issue:2 Topics: Animals; Anti-Allergic Agents; Antigens; Basophils; Calcimycin; Cell Degranulation; Cell Line, Tumor; Cell-Free System; Enzyme Inhibitors; Hyaluronoglucosaminidase; Immunoglobulin E; Leukotriene C4; Lipoxygenase; Naphthoquinones; Rats; Vitamin K 3	2014
A UHPLC-MS/MS method for simultaneous determination of six flavonoids, gallic acid and 5,8-dihydroxy-1,4-naphthoquinone in rat plasma and its application to a pharmacokinetic study of Cortex Juglandis Mandshuricae extract. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2014, May-01, Volume: 958 Topics: Animals; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Flavonoids; Gallic Acid; Limit of Detection; Male; Naphthoquinones; Rats; Rats, Wistar; Tandem Mass Spectrometry	2014
Design, synthesis, and biological evaluation of shikonin and alkannin derivatives as potential anticancer agents via a prodrug approach. ChemMedChem, 2014, Volume: 9, Issue:12 Topics: Alkylation; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Drug Design; Female; Male; Mice; Microsomes, Liver; Naphthoquinones; Neoplasms; Prodrugs; Rats; Reactive Oxygen Species; Stereoisomerism; Structure-Activity Relationship; Transplantation, Heterologous; Transplantation, Homologous	2014
Total synthesis of hybocarpone, a cytotoxic naphthazarin derivative from the lichen Lecanora hybocarpa, and related compounds. Natural product communications, 2014, Volume: 9, Issue:12 Topics: Dimerization; Lichens; Magnetic Resonance Spectroscopy; Naphthoquinones; Stereoisomerism	2014
Naphthazarin enhances ionizing radiation-induced cell cycle arrest and apoptosis in human breast cancer cells. International journal of oncology, 2015, Volume: 46, Issue:4 Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Cycle Checkpoints; Cell Proliferation; Chemoradiotherapy; Cyclin-Dependent Kinase Inhibitor p21; Dose-Response Relationship, Drug; Female; Gene Expression Regulation, Neoplastic; Humans; MCF-7 Cells; Naphthoquinones; Promoter Regions, Genetic; Radiation-Sensitizing Agents	2015
Stimulation of Suicidal Erythrocyte Death by Naphthazarin. Basic & clinical pharmacology & toxicology, 2015, Volume: 117, Issue:6 Topics: Annexin A5; Antineoplastic Agents; Apoptosis; Biomarkers; Calcium Signaling; Cell Size; Ceramides; Dose-Response Relationship, Drug; Erythrocyte Membrane; Erythrocytes; Humans; Naphthoquinones; Neuroprotective Agents; Oxidative Stress; Phosphatidylserines; Reactive Oxygen Species; Time Factors	2015
Synthesis of naphthazarin derivatives and identification of novel thioredoxin reductase inhibitor as potential anticancer agent. European journal of medicinal chemistry, 2017, Nov-10, Volume: 140 Topics: Antineoplastic Agents; Apoptosis; Enzyme Inhibitors; Gene Silencing; Naphthoquinones; Oxidative Stress; Thioredoxin-Disulfide Reductase	2017
Maintenance and pharmacologic targeting of ROR1 protein levels via UHRF1 in t(1;19) pre-B-ALL. Oncogene, 2018, Volume: 37, Issue:38 Topics: CCAAT-Enhancer-Binding Proteins; Cell Line, Tumor; Cell Survival; Down-Regulation; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Molecular Targeted Therapy; Naphthoquinones; Receptor Tyrosine Kinase-like Orphan Receptors; Ubiquitin-Protein Ligases	2018
Effects of Naphthazarin (DHNQ) Combined with Lawsone (NQ-2-OH) or 1,4-Naphthoquinone (NQ) on the Auxin-Induced Growth of International journal of molecular sciences, 2019, Apr-11, Volume: 20, Issue:7 Topics: Cotyledon; Indoleacetic Acids; Naphthoquinones; Oxidative Stress; Plant Growth Regulators; Zea mays	2019
Application of "macromolecular crowding" in vitro to investigate the naphthoquinones shikonin, naphthazarin and related analogues for the treatment of dermal scars. Chemico-biological interactions, 2019, Sep-01, Volume: 310 Topics: Animals; Apoptosis; Cell Line; Cicatrix; Cicatrix, Hypertrophic; Collagen; Extracellular Matrix; Fibroblasts; Humans; Models, Biological; Naphthoquinones; Skin	2019
Selective binding of Ni Biotechnology progress, 2020, Volume: 36, Issue:4 Topics: Boraginaceae; Colorimetry; Copper; Esters; Fluorescent Dyes; Ions; Metals; Naphthoquinones; Nickel; Plant Roots	2020
Synthesis, Cytotoxic Activity Evaluation and Quantitative Structure-Activity Analysis of Substituted 5,8-Dihydroxy-1,4-Naphthoquinones and their Marine drugs, 2020, Nov-29, Volume: 18, Issue:12 Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Glycosides; Inhibitory Concentration 50; Mice; Molecular Structure; Naphthoquinones; Neuroblastoma; Quantitative Structure-Activity Relationship; Sea Urchins	2020
Staphylococcus aureus membrane-damaging activities of four phenolics. FEMS microbiology letters, 2021, 07-09, Volume: 368, Issue:13 Topics: Anti-Bacterial Agents; Catechin; Cell Membrane; Coumarins; Naphthoquinones; Parabens; Phenols; Staphylococcus aureus	2021
Non-Covalent Forces in Naphthazarin-Cooperativity or Competition in the Light of Theoretical Approaches. International journal of molecular sciences, 2021, Jul-27, Volume: 22, Issue:15 Topics: Hydrogen Bonding; Molecular Dynamics Simulation; Naphthoquinones; Quantum Theory	2021
Fe(III)-Naphthazarin Metal-Phenolic Networks for Glutathione-Depleting Enhanced Ferroptosis-Apoptosis Combined Cancer Therapy. Small (Weinheim an der Bergstrasse, Germany), 2023, Volume: 19, Issue:19 Topics: Apoptosis; Ferric Compounds; Ferroptosis; Glutathione; Metals; Naphthoquinones; Neoplasms; Phenols	2023