naltrexone has been researched along with u-50488 in 329 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 26 (7.90) | 18.7374 |
| 1990's | 155 (47.11) | 18.2507 |
| 2000's | 98 (29.79) | 29.6817 |
| 2010's | 46 (13.98) | 24.3611 |
| 2020's | 4 (1.22) | 2.80 |
| Authors | Studies |
|---|---|
| Burkard, WP; Eggstein-Aeppli, L; Schmidhammer, H; Smith, CF | 1 |
| Befort, K; Bloch, B; Charron, G; Gavériaux-Ruff, C; Kieffer, B; Lannes, B; Mattéi, MG; Matthes, H; Micheletti, G; Simonin, F | 1 |
| Bell, GI; Breder, CD; Kong, H; Raynor, K; Reisine, T; Takeda, J; Yasuda, K | 1 |
| Adapa, ID; Auh, JS; Berzetei-Gurske, IP; Brandt, SR; Craymer, K; Farrington, L; Haggart, D; Kennedy, JM; O'Brien, A; Polgar, WE; Rodriguez, L; Schwartz, RW; Toll, L; White, A | 1 |
| Carrupt, PA; Crivori, P; Cruciani, G; Testa, B | 1 |
| Bidlack, JM; Knapp, BI; Neumeyer, JL; Peng, X | 1 |
| Bidlack, JM; Bu, Y; Cohen, DJ; Lou, R; Lu, Q; VanAlstine, MA; Wentland, MP | 1 |
| Bidlack, JM; Bu, Y; Cohen, DJ; Denhardt, C; Ganorkar, R; Guo, C; Jin, J; Lou, R; Lu, Q; VanAlstine, MA; Wentland, MP | 1 |
| Dewey, WL; Kellogg, GE; Mosier, PD; Scoggins, KL; Selley, DE; Stevens, DL; Yuan, Y; Zaidi, SA; Zhang, Y | 1 |
| Bourgoin, S; Cesselin, F; Collin, E; Ferhat, L; Hamon, M; Mantelet, S; Mauborgne, A | 1 |
| Craft, RM; Dykstra, LA | 2 |
| Bourgoin, S; Cesselin, F; Collin, E; Ferhat, L; Hamon, M | 1 |
| Kamei, J; Kasuya, Y; Tanihara, H | 2 |
| LaVigne, SD; Lookingland, KJ; Manzanares, J; Moore, KE; Wagner, EJ | 1 |
| Masukawa, Y; Misawa, M; Nagase, H; Shiozaki, Y; Suzuki, T | 1 |
| Blackford, SP; Kuhn, CM; Little, PJ | 1 |
| Leyton, M; Stewart, J | 1 |
| Bennett, EL; Colombo, PJ; Martinez, JL; Rosenzweig, MR | 1 |
| Misawa, M; Nagase, H; Narita, M; Suzuki, T; Takahashi, Y | 1 |
| Misawa, M; Nagase, H; Narita, M; Suzuki, T | 2 |
| Kavaliers, M; Teskey, GC | 1 |
| Adamson, WT; Blackford, S; Kuhn, CM; Windh, RT | 1 |
| Agbas, A; Ahmed, MS; Cemerikic, B; Cheng, J | 1 |
| Hoffman, DC; West, TE; Wise, RA | 1 |
| Frank, C; Proietti, ML; Sagratella, S; Scotti de Carolis, A; Zeng, YC | 1 |
| Billington, CJ; Grace, M; Levine, AS | 1 |
| Kaneto, H; Senda, T; Takahashi, M | 1 |
| Gannon, RL; Terrian, DM | 1 |
| Godin, C; Henry, JL; Rochford, J | 1 |
| Mueller, J; Quock, RM | 1 |
| Fischbach, PS; McCleskey, EW; Schroeder, JE; Zheng, D | 1 |
| Cone, EJ; Vaupel, DB | 1 |
| Cappell, H; Lê, AD; Poulos, CX; Walker, MJ | 1 |
| Billington, CJ; Grace, M; Levine, AS; Portoghese, PS | 1 |
| Abbott, FV | 1 |
| Cone, EJ; Johnson, RE; Su, TP; Vaupel, DB | 1 |
| Cowan, A; Murray, CW | 1 |
| Heyman, JS; Koslo, RJ; Porreca, F; Qi, JA; Sheldon, RJ | 1 |
| Dykstra, LA | 1 |
| Heijna, MH; Hogenboom, F; Mulder, AH; Padt, M; Portoghese, PS; Schoffelmeer, AN | 1 |
| Kaneto, H; Senda, T; Takahashi, M; Tokuyama, S | 1 |
| Bronson, ME; Sparber, SB | 1 |
| Echevarria, E; Holaday, JW; Lipkowski, AW; Portoghese, PS; Takemori, AE; Tortella, FC | 1 |
| Bergman, J; Warren, PH | 1 |
| Dougall, IG; Leff, P | 1 |
| Fukagawa, Y; Katz, JL; Suzuki, T | 1 |
| Evans, RG; Ludbrook, J; Van Leeuwen, AF | 1 |
| Jackson, HC; Kitchen, I | 1 |
| Bals-Kubik, R; Herz, A; Shippenberg, TS | 1 |
| Calcagnetti, DJ; Fanselow, MS; Helmstetter, FJ | 1 |
| Smith, CB | 1 |
| Burks, TF; Fox, DA | 1 |
| Ho, BY; Naeseth, JS; Portoghese, PS; Takemori, AE | 1 |
| Cox, BM; Frattali, A; Portoghese, PS; Takemori, AE; Werling, LL | 1 |
| Portoghese, PS; Schwartz, MM; Takemori, AE | 1 |
| Dykstra, LA; Negus, SS | 1 |
| Leander, JD | 1 |
| Bhargava, HN; Gulati, A | 1 |
| Hayes, AG; Skingle, M; Tyers, MB | 2 |
| Lipkowski, AW; Portoghese, PS; Takemori, AE | 1 |
| Portoghese, PS; Takemori, AE | 1 |
| Hayes, AG; Stewart, BR | 1 |
| Hayes, AG; Sheehan, MJ; Tyers, MB | 1 |
| Hynes, MD; Leander, JD; Reel, JK; Zimmerman, DM | 1 |
| Dykstra, LA; Gmerek, DE; Winger, G; Woods, JH | 1 |
| Culpepper-Morgan, JA; Holt, PR; Kreek, MJ; LaRoche, D | 1 |
| Laorden, ML; Llobell, F | 1 |
| Akaike, A; Fukuda, K; Kaneko, S; Mori, Y; Satoh, M; Yada, N | 1 |
| Chen, L; Gu, Y; Huang, LY | 1 |
| Archer, S; Glick, SD; Maisonneuve, IM; Raucci, J | 1 |
| Carboni, L; Gomez-Vidal, JA; Marrazzo, A; Pasquinucci, L; Prezzavento, O; Ronsisvalle, G; Spampinato, S; Vittorio, F | 1 |
| Maggi, R; Martini, L; Pimpinelli, F; Piva, F | 1 |
| Chen, C; Chen, YW; Kim de Riel, J; Kunapuli, S; Liu-Chen, LY; Xue, JC; Yu, L; Zhu, J | 1 |
| Adler, MW; Bussiere, JL; Eisenstein, TK; Geller, EB; Meissler, JJ; Rogers, TJ | 1 |
| Bélisle, S; Bellabarba, D; Gallo-Payet, N; Lehoux, JG; Petit, A | 1 |
| Devine, DP; Leone, P; Pocock, D; Wise, RA | 1 |
| Martín, MI; Milanés, MV; Vargas, ML | 1 |
| Diop, L; Junien, JL; Pascaud, X; Rivière, PJ | 1 |
| Coenen, A; Lasoń, W; Machelska, H; Przewłocka, B; Przewłocki, R; van Luijtelaar, G | 1 |
| Moerschbaecher, JM; Pakarinen, ED; Woods, JH | 1 |
| Adler, MW; Eisenstein, TK; Guan, L; Rogers, TJ; Townsend, R | 1 |
| Avidor-Reiss, T; Barg, J; Ezra, V; Levy, R; Matus-Leibovitch, N; Saya, D; Vogel, Z; Zippel, R | 1 |
| Bidlack, JM; Joseph, DB | 1 |
| Archer, S; Glick, SD; Maisonneuve, IM | 1 |
| Brent, PJ; Cantarell, PA; Chahl, LA; Kavanagh, C | 1 |
| Funada, M; Misawa, M; Nagase, H; Narita, M; Suzuki, T | 1 |
| Ingenito, AJ; Wang, JQ | 1 |
| Buéno, L; Gué, M; Junien, JL | 1 |
| Riley, AL; Smurthwaite, ST | 1 |
| Benoliel, JJ; Bourgoin, S; Cesselin, F; Collin, E; Hamon, M; Mauborgne, A | 1 |
| Cui, Y; Lee, T; Wang, LC | 1 |
| Chen, C; DeRiel, JK; Kunapuli, S; Liu-Chen, LY; Xue, JC; Yu, L; Zhu, J | 1 |
| Boylan, CB; Kehoe, P | 1 |
| Bell, GI; Kong, H; Raynor, K; Reisine, T; Takeda, J; Yano, H | 1 |
| Dassaud, M; Diop, L; Junien, JL; Pascaud, X; Rivière, PJ | 1 |
| de Costa, BR; Petrov, ES; Rice, KC; Robinson, SR; Smotherman, WP; Varlinskaya, EI | 1 |
| Giagnoni, G; Massi, P; Parolaro, D; Patrini, G; Rubino, T; Venier, I | 1 |
| Randich, A; Robertson, JD; Willingham, T | 1 |
| Bidlack, JM; Lawrence, DM | 1 |
| Adloff, M; Angel, F; Chamouard, P; Klein, A; Martin, E | 1 |
| D'Alecy, LG; Mayfield, KP | 1 |
| Hamann, SR; Martin, WR | 1 |
| Martin, BR; Smith, PB; Welch, SP | 1 |
| Brusa, L; D'Amore, A; Lorenzini, P; Massotti, M | 1 |
| Kapusta, DR; Obih, JC | 1 |
| Walker, EA; Young, AM | 1 |
| Bianchi, M; Panerai, AE | 1 |
| Ai, Y; Butelman, ER; de Costa, BR; Negus, SS; Woods, JH | 1 |
| Bortot, AT; Carden, SE; Hofer, MA | 1 |
| Grubb, BD; Schaible, HG; Stiller, RU | 1 |
| Hitosugi, H; Kamei, J; Kasuya, Y; Kawashima, N; Misawa, M; Nagase, H | 1 |
| Childers, SR; Konkoy, CS | 1 |
| DeHaven-Hudkins, DL; Komer, KM; Mavunkel, BJ; Peterson, JA; Rzeszotarski, WJ | 1 |
| Dosaka-Akita, K; Holaday, JW; Long, JB; Tortella, FC | 1 |
| Moody, CA; Robinson, SR; Smotherman, WP; Spear, LP | 1 |
| Chiappinelli, VA; Fletcher, GH | 1 |
| De Sarro, A; De Sarro, G; Masuda, Y; Sinopoli, S; Trimarchi, GR | 1 |
| Collins, KA; Portoghese, PS; Tseng, LF | 1 |
| Bull, PM; Clarke, G; Douglas, AJ; MacMillan, SJ; McGrory, BG; Neumann, I; Russell, JA; Way, SA; Wright, DM | 1 |
| Amico, MC; Morrone, LA; Romanelli, L; Valeri, P | 1 |
| Welch, SP | 1 |
| Bourgoin, S; Cesselin, F; Collin, E; Frechilla, D; Hamon, M; Le Bars, D; Pohl, M | 1 |
| Funada, M; Misawa, M; Nagase, H; Narita, M; Suzuki, T; Takahashi, Y; Takamori, K | 1 |
| Lookingland, KJ; Manzanares, J; Moore, KE; Wagner, EJ | 1 |
| Baumhaker, Y; Gafni, M; Keren, O; Sarne, Y | 1 |
| Iwamoto, Y; Kamei, J; Kasuya, Y; Misawa, M; Nagase, H; Suzuki, T | 1 |
| Alcaraz, C; Milanés, MV; Vargas, ML | 1 |
| Itoh, J; Kameyama, T; Ukai, M | 1 |
| Kest, B; Liebeskind, JC; Mogil, JS; Sadowski, B; Sternberg, WF | 1 |
| Beattie, MS; Behrmann, DL; Bresnahan, JC | 1 |
| Heidbreder, C; LeFevour, A; Shippenberg, TS | 1 |
| Grouhel, A; Wettstein, JG | 1 |
| Dawson-Basoa, ME; Gintzler, AR | 1 |
| Bot, G; Chahl, LA | 1 |
| Durham, RA; Johnson, JD; Lookingland, KJ; Moore, KE | 1 |
| Kameyama, T; Kobayashi, T; Shan-Wu, X; Ukai, M | 1 |
| Duncan, MJ; Elde, RP; Gurwell, JA; Hauser, KF; Maderspach, K; Stiene-Martin, A | 1 |
| Feuerstein, TJ; Gleichauf, O; Jackisch, R; Landwehrmeyer, GB; Peckys, D; Scheremet, R | 1 |
| Yuan, CS | 1 |
| Hiramatsu, M; Hyodo, T; Kameyama, T | 1 |
| Hong, JS; Hudson, PM; Jin, L; Kong, LY; McMillian, MK | 1 |
| Angel, F; Chevalier, E; Dahl, SG; Friese, N; Junien, JL; Pascaud, X; Riviere, PJ | 1 |
| Ho, ST; Lee, SC; Tao, PL; Wang, JJ | 1 |
| Lishmanov, YB; Maslov, LN; Smagin, GN; Ugdyzhekova, DS | 1 |
| Lin, CE; Mello, NK; Negus, SS; Portoghese, PS | 1 |
| Rothe, KS; Stevens, CW | 1 |
| Barton, C; Bray, GA; Ookuma, K; York, DA | 2 |
| Burke, TF; Garner, HR; Lawhorn, CD; Stoner, JM; Wessinger, WD | 1 |
| Dahl, SG; Diop, L; Friese, N; Lambert, C; Rivière, PJ | 1 |
| Childers, SR; Sim, LJ | 1 |
| Wong, TM; Zhang, WM | 1 |
| Li, HY; Wang, HX; Wong, TM; Yu, XC | 1 |
| Makhay, MM; Poling, A; Young, AM | 1 |
| Fábián, G; Offermanns, S; Rottmann, M; Spicher, K; Szücs, M | 1 |
| Ingenito, AJ; Zhai, QZ | 1 |
| Gu, Y; Huang, LY; Lai, SL | 1 |
| Matsuzawa, S; Misawa, M; Nagase, H; Suzuki, T | 2 |
| Chao, CC; Gekker, G; Hu, S; Kravitz, F; Peterson, PK | 1 |
| Hata, F; Nishio, H; Nishiwaki, H; Saitoh, N; Takeuchi, T | 1 |
| Kapusta, DR; Kenigs, VA; Sezen, SF | 1 |
| Barke, RA; Loh, HH; Roy, S | 1 |
| Andoh, T; Ito, H; Kamiya, Y; Oka, K; Watanabe, I | 1 |
| Bian, JS; Wong, TM; Xia, Q; Zhang, WM | 1 |
| Brown, CH; Leng, G; Ludwig, M | 1 |
| Butelman, ER; Ko, MC; Woods, JH | 1 |
| Bian, JS; Wang, HX; Wong, TM; Wu, S; Yu, XC; Zhang, WM | 1 |
| Kowalski, J | 1 |
| Hallermann, S; Müller, W; Swandulla, D | 1 |
| De Vries, TJ; Homberg, JR; Mulder, AH; Nestby, P; Schoffelmeer, AN; Vanderschuren, LJ; Wardeh, G | 1 |
| Foss, JF; Yuan, CS | 1 |
| Goto, K; Ishige, A; Komatsu, Y; Omiya, Y; Suzuki, Y | 1 |
| Li, HY; Wong, TM; Wu, S | 1 |
| Ness, TJ | 1 |
| Amico, MC; Mattioli, F; Morrone, LA; Romanelli, L; Valeri, P | 1 |
| Holtzman, SG; Powell, KR | 1 |
| Pei, JM; Wang, HX; Wong, TM; Yu, XC | 1 |
| Hori, T; Hosoi, M; Kamikawa, H; Katafuchi, T; Yamamoto, T | 1 |
| Butelman, ER; Johnson, MD; Ko, MC; Mosberg, HI; Willmont, KJ; Woods, JH | 1 |
| Dun, NJ; Hwang, BH; Mizoguchi, H; Nagase, H; Narita, M; Oji, DE; Tseng, LF | 1 |
| Lohmann, AB; Welch, SP | 1 |
| Collins, RL; McDougall, SA; Nazarian, A; Zavala, AR | 1 |
| Chao, CC; Gekker, G; Heyes, MP; Hu, S; Lokensgard, JR; Peterson, PK | 1 |
| Chan, I; Gan, T; Pei, J; Wong, T | 1 |
| Goto, K; Ishige, A; Komatsu, Y; Omiya, Y | 1 |
| Chaban, VV; Ennes, HS; Gschossmann, JM; Lembo, T; Mayer, EA; McRoberts, JA; Raybould, HE; Young, SH | 1 |
| Allescher, HD; Brechmann, C; Hahn, A; Schusdziarra, V; Storr, M | 1 |
| Castells, MT; Laorden, ML; Martínez, MD; Martínez, PJ; Milanés, MV | 1 |
| Misawa, M; Mizoguchi, H; Nagase, H; Narita, M; Suzuki, T; Takahashi-Nakano, Y; Tseng, LF; Yajima, Y | 1 |
| Ballet, S; Cesselin, F; Collin, E; Hamon, M; Mauborgne, A | 1 |
| Hahn, B; Shoaib, M; Stolerman, IP | 1 |
| Cui, CL; Han, JS; Wu, LZ | 1 |
| Kuzmin, A; Ogren, SO; Sandin, J; Terenius, L | 1 |
| Haddad, GG; Xia, Y; Zhang, J | 1 |
| Brené, S; Franck, J; Lindholm, S; Werme, M | 1 |
| Brandão, ML; Nobre, MJ; Sante, AB | 1 |
| Krall, CM; McDougall, SA; Nazarian, A; Osburn, JR | 1 |
| Endoh, T; Izumimoto, N; Kamei, J; Mizoguchi, H; Nagase, H; Narita, M; Saitoh, A; Suzuki, T; Tajima, A; Tseng, LF | 1 |
| Kamei, J; Nagase, H | 1 |
| Cho, CH; Pei, JM; Wang, GY; Wang, WP; Wong, TM; Wu, S; Zhou, JJ | 1 |
| Billington, CJ; Grace, MK; Jewett, DC; Jones, RM; Levine, AS; Portoghese, PS | 1 |
| Bidlack, JM; Chuang, LF; Chuang, RY; Doi, RH; Suzuki, S | 1 |
| Adler, MW; Cowan, A; Eisenstein, TK; Gaughan, J; Geller, EB; Meissler, JJ; Rahim, RT; Rogers, TJ | 1 |
| Kieffer, BL; Maidment, NT; Matthes, HW; Skoubis, PD; Walwyn, WM | 1 |
| Adler, MW; Eisenstein, LK; Hilburger, ME; MacFarland, AS; Meissler, LJ; Peng, X; Rahim, RT; Rogers, TJ; Wan, AC | 1 |
| Fiore, P; Gannon, RL; Tierno, A | 1 |
| Eggert, A; Fischer, WH; Kämpgen, E; Kirst, A; Lutz, WK; Wack, C | 1 |
| Gallo, RV; Zhang, Q | 1 |
| Bastia, E; Bertorelli, R; Citterio, F; Corradini, L; Forlani, A; Ongini, E | 1 |
| Eisenach, JC; Sandner-Kiesling, A | 1 |
| Jones, RM; Linsenmayer, DC; Mello, NK; Negus, SS; Portoghese, PS | 1 |
| Auerbach, SB; Tao, R | 1 |
| Hu, S; Lokensgard, JR; Peterson, PK; Sheng, WS | 1 |
| Bayer, J; Bennett, R; Figlewicz, DP; Sipols, AJ | 1 |
| Akao, Y; Arakawa, S; Fujisawa, M; Goto, K; Gotoh, A; Kamidono, S; Okada, H; Sasaki, H; Sengoku, A; Shirakawa, T | 1 |
| Hung, KC; Leitermann, R; Mizoguchi, H; Nagase, H; Narita, M; Suzuki, T; Tseng, LF | 1 |
| Kishioka, S; Ko, MC; Lee, H; Mosberg, HI; Naughton, NN; Sobczyk-Kojiro, K; Song, MS; Woods, JH | 1 |
| Buck, J; Loeb, J; Neudeck, BL | 1 |
| Leitermann, R; Mizoguchi, H; Nagase, H; Spaulding, A; Tseng, LF; Wu, HE | 1 |
| Sacerdote, P | 1 |
| Cheung, YF; Li, GR; Wong, TM; Xiao, GS; Zhou, JJ | 1 |
| Flory, GS; Ko, MC; Lee, H; Willmont, KJ; Woods, JH | 1 |
| Raffa, RB; Stagliano, GW; Umeda, S | 1 |
| Chen, M; Kam, KW; Qi, JS; Wong, TM; Wu, S; Yan, WY; Zhou, JJ | 1 |
| Caron, MG; Chavkin, C; Czyzyk, TA; Lefkowitz, RJ; McLaughlin, JP; Myers, LC; Pintar, JE; Zarek, PE | 1 |
| Chudapongse, N; Ho, IK; Kim, SY; Kramer, RE; Sasaki, K | 1 |
| Greene, JL; McClean, JM; Smith, MA | 1 |
| Bernardi, G; D'Angelo, V; Lavaroni, F; Martella, G; Martorana, A; Spadoni, F; Stefani, A | 1 |
| Leitermann, RJ; Mizoguchi, H; Nagase, H; Narita, M; Suzuki, T; Tseng, LF | 1 |
| Negus, SS | 1 |
| Canpolat, S; Kelestimur, H; Kumru, S; Kutlu, S; Ozcan, M; Sandal, S; Yilmaz, B | 1 |
| Clemente, JT; Gear, RW; Parada, CA; Tambeli, CH; Veiga, MC | 1 |
| Fujimura, T; Ito, K; Kawamura, S; Mizoguchi, H; Murayama, K; Nakayama, D; Sakurada, C; Sakurada, S; Sakurada, T; Sato, T; Watanabe, C; Watanabe, H | 1 |
| Goldberg, SR; Solinas, M | 1 |
| Coupar, IM; Gray, AC; White, PJ | 1 |
| Aru, GN; Bortolato, M; Fà, M; Frau, R; Gessa, GL; Manunta, M; Mereu, G; Orrù, M; Puddu, M | 1 |
| Guaza, C; Llorente, R; Marco, EM; Moreno, E; Pérez-Alvarez, L; Viveros, MP | 1 |
| Benabid, AL; Berger, F; Buggia, V; Gilbert, F; Lévesque, D; Sgambato-Faure, V | 1 |
| Barlow, MA; Caffrey, JL; Deo, S; Johnson, S | 1 |
| Buxbaum, JD; Cho, J; Jacobson, DA; Landa, LR; Philipson, LH; Roe, MW; Tamarina, NA | 1 |
| Bidlack, JM; Parkhill, AL | 1 |
| Bruchas, MR; Chavkin, C; Lowe, JD; Macey, TA | 1 |
| Qi, W; Smith, FG | 1 |
| Baron, DA; Raffa, RB; Tallarida, RJ | 1 |
| Doyon, WM; Gonzales, RA; Howard, EC; Shippenberg, TS | 1 |
| Simansky, KJ; Ward, HG | 1 |
| Beadles-Bohling, AS; Wiren, KM | 1 |
| Agirregoitia, E; Carracedo, A; Casis, L; Gil, J; Irazusta, J; Ochoa, C; Subiran, N; Valdivia, A | 1 |
| Becker, GL; France, CP; Gong, ZH; Li, JX; Traynor, JR | 1 |
| Bruchas, MR; Chavkin, C; Gendron, L; Ippolito, DL; Xu, M | 1 |
| Herzog, H; Loacker, S; Sayyah, M; Schwarzer, C; Wittmann, W | 1 |
| Betourne, A; Daumas, S; Francés, B; Halley, H; Lassalle, JM; Lipp, HP; Wolfer, DP | 1 |
| Peña, RT; Pruhs, RJ; Quock, RM | 1 |
| Lunzer, MM; Portoghese, PS | 1 |
| Ebenezar, KK; Qi, W; Samhan, MA; Smith, FG | 1 |
| Lasukova, TV; Lishmanov, AIu; Maslov, LN; Platonov, AA | 1 |
| Labuz, D; Machelska, H; Mousa, SA; Schäfer, M; Stein, C | 1 |
| Dahlin, I; Franck, J; Georgieva, J; Lindholm, S; Rosin, A | 1 |
| Hamabe, W; Mashida, E; Nagae, R; Tokuyama, S | 1 |
| Crawford, D; Lasukova, TV; Lishmanov, AY; Maslov, LN; Wong, TM | 1 |
| Bruchas, MR; Chavkin, C; Land, BB; Lemos, JC; Melief, EJ; Xu, M | 1 |
| An, K; Arita, H; Chiba, S; Hanaoka, K; Hayashida, M; Huang, W; Shu, H | 1 |
| Azad, SC; Beyer, A; Huge, V; Rammes, G; Zieglgänsberger, W | 1 |
| Caliari, MV; Duarte, ID; Francischi, JN; Maltos, KL; Pacheco, CM; Pacheco, DF; Queiroz-Junior, CM | 1 |
| Jing, L; Liu, C; Wang, H; Wong, TM; Wu, G; Yang, J; Yang, Y | 1 |
| Gaburro, S; Herzog, H; Rosskothen, I; Schunk, E; Schwarzer, C; Singewald, N; Wittmann, W | 1 |
| Martin, KK; Stahlheber, BW; Stevens, CW | 1 |
| Antapasis, J; Bolaños Guzmán, CA; Herrera, CM; Poveromo, LB; Wiley, MD | 1 |
| Carey, AN; Dunton, O; Lyons, AM; McLaughlin, JP; Shay, CF | 1 |
| Philibin, SD; Porter, JH; Vann, RE; Varvel, SA; Walentiny, DM; Wise, LE | 1 |
| Kitamura, T; Ogawa, M; Yamada, Y | 1 |
| Bing, G; Jang, CG; Kim, HC; Koo, KH; Nabeshima, T; Oh, CH; Oh, KW; Park, DH; Shin, EJ; Yamada, K | 1 |
| Cui, Q; Gu, CH; Guo, HT; Hui, B; Liang, C; Pei, JM; Peng, Z; Rong, F; Tao, C; Wang, YM; Ye, MX; Yi, DH; Yu, SQ; Zhang, QY; Zhang, SM; Zhao, Y | 1 |
| Aita, M; Bruchas, MR; Chavkin, C; Giardino, WJ; Hnasko, TS; Land, BB; Messinger, D; Palmiter, RD; Schattauer, S | 1 |
| Fukuda, K; Koyama, T | 1 |
| Chefer, VI; Shippenberg, TS; Tejeda, HA; Zapata, A | 1 |
| Ploner, F; Theisen, MM; Van Aken, HK; Weber, TP | 1 |
| Beardsley, PM; Carroll, FI; Howard, JL; Pollard, GT | 1 |
| Ismayilova, N; Shoaib, M | 1 |
| Carey, AN; Gomes, SM; McLaughlin, JP; Sperling, RE; Sypek, EI | 1 |
| Chavkin, C; Li, S; Schindler, AG | 1 |
| Lawson, KP; Mokha, SS; Nag, S; Thompson, AD | 1 |
| Gu, C; Guo, H; Kaye, AD; Li, J; Pei, J; Sun, Z; Tong, G; Wang, Y; Wei, X; Yi, D; Yu, S; Zhang, Q | 1 |
| Chen, BP; Gao, YF; Mao, HJ; Wang, HP; Xia, Q | 1 |
| Bergman, J; Paronis, CA | 1 |
| Chen, BP; Fan, FY; Mao, HJ; Xia, Q | 1 |
| Chicre-Alcântara, TC; Clemente-Napimoga, JT; Fischer, L; Melo, V; Parada, CA; Tambeli, CH; Torres-Chávez, KE | 1 |
| Li, M; McMillan, DE; Wessinger, WD | 1 |
| Chudnovskaya, D; Cowan, A; Huang, P; Liu-Chen, LY; Rasakham, K; Wang, YJ | 1 |
| Kemppainen, H; Kiianmaa, K; Raivio, N; Suo-Yrjo, V | 1 |
| Anisimova, VA; Grechko, OIu; Spasov, AA | 1 |
| Hosoya, T; Imai, S; Kuzumaki, N; Morita, H; Nagasawa, A; Nagase, H; Narita, M; Okada, Y; Okano, H; Okano, HJ; Suzuki, A; Suzuki, T; Yamamizu, K; Yamashita, JK | 1 |
| Harshberger, E; Valdez, GR | 1 |
| Natividad, LA; O'Dell, LE; Orfila, JE; Tejeda, HA; Torres, OV | 1 |
| Ding, D; Fu, L; Han, D; Li, H; Liu, J; Xiu, J | 1 |
| Elsamani, L; Grachev, P; Hu, MH; Li, XF; Lightman, SL; Lin, YS; Millar, RP; O'Byrne, KT; Paterson, SJ | 1 |
| Baroffio, M; Brusasco, V; Crimi, E; Rehder, K | 1 |
| Bueno, FR; Fan, R; Guo, HT; Kaye, AD; Kaye, AJ; Li, J; Pei, JM; Shi, QX; Wang, YM; Xu, XZ; Yi, DH; Yu, SQ; Zhang, LJ; Zhang, SM | 1 |
| Kissler, JL; Walker, BM | 1 |
| Gillett, K; Harshberger, E; Valdez, GR | 1 |
| Al-Hasani, R; Bruchas, MR; Foshage, AM; McCall, JG | 1 |
| Bilkei-Gorzo, A; Mauer, D; Michel, K; Zimmer, A | 1 |
| Coen, K; Funk, D; Grella, SL; Lê, AD; Li, Z | 1 |
| Czachowski, C; Henderson-Redmond, A | 1 |
| Akbari, HA; Cahill, CM; Carroll, FI; Evans, CJ; Lutfy, K; Pradhan, AA; Roberts, KW; Taylor, AM; Walwyn, W | 1 |
| Coen, K; Funk, D; Lê, AD | 1 |
| Fan, R; Feng, N; Guo, F; Jia, M; Li, J; Ma, X; Pei, J; Shang, Y; Wang, H; Wang, Y; Yin, Y; Zhang, S; Zhou, J | 1 |
| Cai, W; Li, J; Wang, J; Zhang, Y | 1 |
| Aubé, J; Bohn, LM; Frankowski, KJ; Morgenweck, J; Prisinzano, TE | 1 |
| Fan, R; Feng, N; Guo, HT; Jia, M; Li, J; Pei, JM; Tian, F; Wang, YM; Zhang, SM; Zheng, XY | 1 |
| Halberstadt, AL; Hyun, J; Powell, SB; Ruderman, MA | 1 |
| Cami-Kobeci, G; Fichna, J; Husbands, S; Jarmuż, A; Wasilewski, A; Zielińska, M | 1 |
| Becker, A; Günther, T; Neurath, H; Schild, L; Schulz, S; Vázquez López, JL | 1 |
| D'Souza, MS; Norman, H; Ward, M | 1 |
| Fan, R; Feng, N; Gu, X; Guo, H; Jia, M; Li, J; Pei, J; Tian, X; Wang, X; Wang, Y; Yang, F; Zhang, S; Zhou, Y | 1 |
| An, R; Fan, R; Feng, N; Gu, X; Guo, H; Jia, M; Li, J; Pei, J; Tian, X; Yang, L; Zhang, S; Zhao, L; Zheng, G; Zhou, Y | 1 |
| Kreek, MJ; Reed, B; Windisch, KA | 1 |
| Anderson, RI; Becker, HC; Bloodgood, DW; Boyt, KM; Griffin, WC; Haun, HL; Kash, TL; Lopez, MF; Pati, D | 1 |
| Cui, Y; Fan, R; Feng, N; Fu, F; Gu, X; Guo, H; Jia, M; Li, J; Liu, Y; Pei, J; Wang, Y; Yang, L; Zhang, F; Zhang, S | 1 |
| Heller, NM; Maher, DP; Walia, D | 1 |
| Fan, R; Feng, N; Fu, F; Guo, H; Li, J; Liu, Y; Liu, Z; Pei, J; Wang, K; Zhang, F; Zhang, S; Zhao, M | 1 |
| Agirregoitia, E; Agirregoitia, N; Olabarrieta, E; Romero-Aguirregomezcorta, J; Totorikaguena, L | 1 |
| Fan, W; Law, PY; Loh, HH; Xu, C; Zhang, Y | 1 |
| Chang, N; Chang, S; Duan, C; Jia, S; Shang, L | 1 |
329 other study(ies) available for naltrexone and u-50488
| Article | Year |
|---|---|
Synthesis and biological evaluation of 14-alkoxymorphinans. 2. (-)-N-(cyclopropylmethyl)-4,14-dimethoxymorphinan-6-one, a selective mu opioid receptor antagonist.
Topics: Animals; Guinea Pigs; In Vitro Techniques; Male; Mice; Morphinans; Narcotic Antagonists; Rats; Receptors, Opioid; Receptors, Opioid, mu | 1989 |
kappa-Opioid receptor in humans: cDNA and genomic cloning, chromosomal assignment, functional expression, pharmacology, and expression pattern in the central nervous system.
Topics: Adenylyl Cyclases; Aged; Amino Acid Sequence; Base Sequence; Central Nervous System; Chromosome Mapping; Chromosomes, Human, Pair 8; Cloning, Molecular; DNA, Complementary; Exons; Genomic Library; Humans; In Situ Hybridization; Ligands; Middle Aged; Molecular Sequence Data; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Proteins; RNA, Messenger; Sequence Homology, Amino Acid; Signal Transduction; Tissue Distribution | 1995 |
Cloning and functional comparison of kappa and delta opioid receptors from mouse brain.
Topics: Amino Acid Sequence; Animals; Base Sequence; Brain Chemistry; Cloning, Molecular; In Situ Hybridization; Mice; Molecular Sequence Data; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Somatostatin; RNA, Messenger; Sequence Homology, Amino Acid; Substrate Specificity; Tissue Distribution | 1993 |
Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications.
Topics: Animals; Aorta, Thoracic; Cocaine; Cyclic AMP; Electric Stimulation; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Mice; Muscle, Smooth; Opioid-Related Disorders; Rats; Receptors, Dopamine; Receptors, Opioid; Receptors, Serotonin; Substance-Related Disorders | 1998 |
Predicting blood-brain barrier permeation from three-dimensional molecular structure.
Topics: Blood-Brain Barrier; Databases, Factual; Models, Chemical; Molecular Conformation; Multivariate Analysis; Permeability; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Pharmacological properties of bivalent ligands containing butorphan linked to nalbuphine, naltrexone, and naloxone at mu, delta, and kappa opioid receptors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; CHO Cells; Cricetinae; Cricetulus; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Ligands; Morphinans; Nalbuphine; Naloxone; Naltrexone; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship | 2007 |
Syntheses and opioid receptor binding properties of carboxamido-substituted opioids.
Topics: Amides; Analgesics, Opioid; Humans; Protein Binding; Receptors, Opioid; Structure-Activity Relationship; Tramadol | 2009 |
Syntheses of novel high affinity ligands for opioid receptors.
Topics: Analgesics, Opioid; Crystallography, X-Ray; Furans; Humans; Ligands; Naltrexone; Narcotic Antagonists; Protein Binding; Receptors, Opioid | 2009 |
Design, syntheses, and pharmacological characterization of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(isoquinoline-3'-carboxamido)morphinan analogues as opioid receptor ligands.
Topics: Animals; CHO Cells; Cricetulus; Drug Design; Humans; Isoquinolines; Ligands; Mice; Molecular Dynamics Simulation; Morphinans; Morphine Dependence; Narcotic Antagonists; Receptors, Opioid, mu; Structure-Activity Relationship | 2015 |
Kappa-/mu-receptor interactions in the opioid control of the in vivo release of substance P-like material from the rat spinal cord.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Kinetics; Male; Models, Neurological; Naloxone; Naltrexone; Pyrrolidines; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord; Substance P | 1992 |
Agonist and antagonist activity of kappa opioids in the squirrel monkey: I. Antinociception and urine output.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Behavior, Animal; Benzodiazepines; Benzomorphans; Drug Interactions; Ethylketocyclazocine; Male; Methadone; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Nociceptors; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Saimiri; Urination | 1992 |
Agonist and antagonist activity of kappa opioids in the squirrel monkey: II. Effect of chronic morphine treatment.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzodiazepines; Benzomorphans; Drug Interactions; Drug Tolerance; Ethylketocyclazocine; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Nociceptors; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Saimiri; Shock; Time Factors | 1992 |
Kappa-opioid receptor stimulation abolishes mu- but not delta-mediated inhibitory control of spinal Met-enkephalin release.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Indoles; Injections, Spinal; Male; Morphinans; Naloxone; Naltrexone; Neurons; Oligopeptides; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1992 |
Modulation of kappa-mediated antitussive activity in rats by a delta-agonist.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Antitussive Agents; Cough; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Indoles; Male; Morphinans; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Reflex | 1992 |
Sexual differences in kappa opioid receptor-mediated regulation of tuberoinfundibular dopaminergic neurons.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Arcuate Nucleus of Hypothalamus; Dihydroxyphenylalanine; Dopamine; Female; Male; Median Eminence; Naltrexone; Narcotic Antagonists; Neurons; Orchiectomy; Ovariectomy; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Sex Characteristics; Tuber Cinereum | 1992 |
The role of mu- and kappa-opioid receptors in cocaine-induced conditioned place preference.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Buprenorphine; Chlorides; Cocaine; Conditioning, Psychological; Lithium; Lithium Chloride; Male; Naltrexone; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1992 |
Mu- and kappa-opiate receptor control of prolactin secretion in rats: ontogeny and interaction with serotonin.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Aging; Animals; Cyproheptadine; Female; Kinetics; Male; Naltrexone; Prolactin; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Serotonin; Sufentanil | 1992 |
The stimulation of central kappa opioid receptors decreases male sexual behavior and locomotor activity.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Behavior, Animal; Body Temperature; Injections; Male; Motor Activity; Naloxone; Naltrexone; Nucleus Accumbens; Preoptic Area; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, kappa; Sexual Behavior, Animal; Tegmentum Mesencephali | 1992 |
Kappa opioid receptor activity modulates memory for peck-avoidance training in the 2-day-old chick.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Animals, Newborn; Avoidance Learning; Chickens; Dose-Response Relationship, Drug; Dynorphins; Male; Memory; Naltrexone; Peptide Fragments; Pyrrolidines; Receptors, Opioid, kappa | 1992 |
Effects of nor-binaltorphimine on the development of analgesic tolerance to and physical dependence on morphine.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics; Analysis of Variance; Animals; Behavior, Animal; Body Weight; Drug Tolerance; Male; Mice; Morphine; Morphine Dependence; Naltrexone; Pyrrolidines; Rats | 1992 |
Pentazocine-induced biphasic analgesia in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics; Animals; Drug Administration Schedule; Drug Interactions; Drug Tolerance; Indoles; Injections, Intraventricular; Male; Mice; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Pentazocine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Time Factors | 1991 |
Modifications of social conflict-induced analgesic and activity responses in male mice receiving chronic opioid agonist and antagonist treatments.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Conflict, Psychological; Enkephalin, Leucine; Infusion Pumps, Implantable; Levorphanol; Male; Mice; Motor Activity; Naltrexone; Narcotic Antagonists; Narcotics; Pain; Pyrrolidines; Receptors, Opioid; Social Behavior; Sodium Chloride | 1991 |
Ontogeny of mu- and kappa-opiate receptor control of the hypothalamo-pituitary-adrenal axis in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenal Glands; Adrenocorticotropic Hormone; Animals; Corticosterone; Dexamethasone; Female; Hypothalamus; Kinetics; Morphine; Naltrexone; Pituitary Gland; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1991 |
Opioids regulate the release of human chorionic gonadotropin hormone from trophoblast tissue.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Benzeneacetamides; Chorionic Gonadotropin; Endorphins; Female; Humans; Morphine; Naltrexone; Placenta; Pregnancy; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Trophoblasts | 1991 |
Ventral pallidal microinjections of receptor-selective opioid agonists produce differential effects on circling and locomotor activity in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Functional Laterality; Globus Pallidus; Male; Microinjections; Motor Activity; Naltrexone; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stereotyped Behavior; Time Factors | 1991 |
In vitro depressant effects of U-54494A, an anticonvulsant related to kappa opioids, in the hippocampus.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Anticonvulsants; Azocines; Calcium; Cell Membrane; Depression, Chemical; Electric Stimulation; Female; Hippocampus; In Vitro Techniques; Membrane Potentials; Naltrexone; Narcotic Antagonists; Neurons; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Synapses; Synaptic Transmission | 1991 |
Beta-funaltrexamine (beta-FNA) decreases deprivation and opioid-induced feeding.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Feeding Behavior; Food Deprivation; Injections, Intraventricular; Male; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa | 1991 |
Role of spinal kappa opioid receptors in the blockade of the development of antinociceptive tolerance to morphine.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Drug Tolerance; Injections, Intraventricular; Injections, Spinal; Injections, Subcutaneous; Male; Mice; Morphine; Naltrexone; Nociceptors; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Spinal Cord | 1991 |
U-50,488H inhibits dynorphin and glutamate release from guinea pig hippocampal mossy fiber terminals.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Calcium; Dynorphins; Enkephalin, Leucine; Glutamates; Guinea Pigs; Hippocampus; Kinetics; Naloxone; Naltrexone; Narcotic Antagonists; Nerve Endings; Potassium Chloride; Pyrrolidines; Synaptosomes | 1991 |
Intrathecal administration of dynorphin A and its fragments increase heart rate and arterial pressure in the urethane anesthetized rat: mediation by a nonopioid mechanism.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Anesthesia, General; Animals; Antihypertensive Agents; Blood Pressure; Diastole; Dynorphins; Heart Rate; Hexamethonium; Hexamethonium Compounds; Injections, Intravenous; Injections, Spinal; Male; Naloxone; Naltrexone; Peptide Fragments; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Reference Values; Systole | 1991 |
Protection by U-50,488H against beta-chlornaltrexamine antagonism of nitrous oxide antinociception in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics; Animals; Fentanyl; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Nitrous Oxide; Pain; Pyrrolidines; Sufentanil | 1991 |
Activation of mu opioid receptors inhibits transient high- and low-threshold Ca2+ currents, but spares a sustained current.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Sequence; Animals; Calcium Channels; Cells, Cultured; Electric Conductivity; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Molecular Sequence Data; Mollusk Venoms; Naltrexone; Narcotic Antagonists; omega-Conotoxin GVIA; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1991 |
Pharmacodynamic and pharmacokinetic actions of ketocyclazocine enantiomers in the dog: absence of sigma- or phencyclidine-like activity.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Behavior, Animal; Dogs; Dose-Response Relationship, Drug; Drug Administration Schedule; Ethylketocyclazocine; Female; Morphine; Naltrexone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, sigma; Stereoisomerism; Time Factors | 1991 |
Chronic selective blockade of mu opioid receptors produces analgesia and augmentation of the effects of a kappa agonist.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics; Animals; Injections, Intraventricular; Injections, Subcutaneous; Male; Mice; Mice, Inbred Strains; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Pyrrolidines; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stereotaxic Techniques | 1991 |
Nor-binaltorphimine decreases deprivation and opioid-induced feeding.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Feeding Behavior; Food Deprivation; Male; Naltrexone; Oligopeptides; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Reference Values | 1990 |
beta-Funaltrexamine antagonizes the analgesic effects of mu and kappa agonists in the formalin test.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Dose-Response Relationship, Drug; Ethylketocyclazocine; Formaldehyde; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Urination | 1990 |
Kappa opioid partial agonist activity of the enkephalin-like pentapeptide BW942C based on urination and in vitro studies in humans and animals.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adult; Amino Acid Sequence; Animals; Diuresis; Dose-Response Relationship, Drug; Drug Tolerance; Enkephalin, Methionine; Enkephalins; Humans; In Vitro Techniques; Male; Molecular Sequence Data; Morphine; Naltrexone; Oligopeptides; Phenazocine; Pyrrolidines; Rabbits; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Urination; Vas Deferens | 1990 |
Effect of nor-binaltorphimine on the behavior of mice and rats receiving multiple injections of U-50,488.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Behavior, Animal; Hypothermia; Male; Mice; Mice, Inbred ICR; Naltrexone; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Yawning | 1990 |
Mu antagonist and kappa agonist properties of beta-funaltrexamine (beta-FNA) in vivo: long-lasting spinal analgesia in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics; Animals; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1990 |
Butorphanol, levallorphan, nalbuphine and nalorphine as antagonists in the squirrel monkey.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Butorphanol; Dose-Response Relationship, Drug; Levallorphan; Male; Methadone; Morphinans; Nalbuphine; Nalorphine; Naltrexone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Saimiri | 1990 |
Opioid receptor-mediated inhibition of dopamine and acetylcholine release from slices of rat nucleus accumbens, olfactory tubercle and frontal cortex.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetylcholine; Animals; Benzomorphans; Cerebral Cortex; Corpus Striatum; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ergolines; In Vitro Techniques; Male; Naloxone; Naltrexone; Nucleus Accumbens; Olfactory Bulb; Oxymetazoline; Pyrrolidines; Quinpirole; Rats; Rats, Inbred Strains; Receptors, Opioid; Septal Nuclei | 1990 |
Further evidence for the implication of a kappa-opioid receptor mechanism in the production of psychological stress-induced analgesia.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics; Animals; Benzomorphans; Drug Tolerance; Electroshock; Indoles; Male; Mice; Mice, Inbred Strains; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Stress, Psychological; Swimming | 1990 |
Antitussive effects of two specific kappa-opioid agonists, U-50,488H and U-62,066E, in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Antitussive Agents; Cisterna Magna; Cough; Injections; Ketanserin; Male; Methysergide; Morphine; Naloxone; Naltrexone; Pyrrolidines; Rats; Rats, Inbred Strains; Reflex | 1990 |
Evidence of single dose opioid dependence in 12- to 14-day-old chicken embryos.
Topics: 1-Methyl-3-isobutylxanthine; 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Chick Embryo; Methadone; Morphine Dependence; Motor Activity; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Pyrrolidines; Receptors, Opioid; Substance Withdrawal Syndrome | 1989 |
Selective kappa antagonist properties of nor-binaltorphimine in the rat MES seizure model.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Anticonvulsants; Electroshock; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Naltrexone; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Seizures | 1989 |
Effects of kappa opioids on schedule-controlled behavior of squirrel monkeys.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzomorphans; Conditioning, Psychological; Dose-Response Relationship, Drug; Electroshock; Male; Morphinans; Morphine; Naltrexone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Saimiri | 1989 |
Estimation of affinities and efficacies for kappa-receptor agonists in guinea-pig ileum.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Binding, Competitive; Cyclazocine; Electric Stimulation; Ethylketocyclazocine; Guinea Pigs; In Vitro Techniques; Male; Models, Biological; Morphinans; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa | 1989 |
Effects of a selective kappa-opioid agonist, U-50,488H, on morphine dependence in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Behavior, Animal; Male; Morphine Dependence; Naltrexone; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Substance Withdrawal Syndrome | 1989 |
Role of central opiate receptor subtypes in the circulatory responses of awake rabbits to graded caval occlusions.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Blood Circulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Hemodynamics; Hemorrhage; Naloxone; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rabbits; Receptors, Opioid; Vena Cava, Inferior | 1989 |
Effects of opioid agonists on urine production in neonatal rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Animals, Newborn; Benzodiazepines; Body Weight; Female; Male; Morphine; Naltrexone; Narcotics; Phentolamine; Pyrrolidines; Rats; Rats, Inbred Strains; Urodynamics | 1989 |
Evidence that the aversive effects of opioid antagonists and kappa-agonists are centrally mediated.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Brain; Conditioning, Operant; Enkephalin, Leucine; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Somatostatin | 1989 |
Role of mu and kappa opioid receptors in conditional fear-induced analgesia: the antagonistic actions of nor-binaltorphimine and the cyclic somatostatin octapeptide, Cys2Tyr3Orn5Pen7-amide.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Behavior, Animal; Fear; Female; Formaldehyde; Naltrexone; Pain; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin | 1989 |
New approaches to the evaluation of opioid agonists and antagonists upon the isolated, electrically stimulated mouse vas deferens preparation.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Benzomorphans; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Oligopeptides; Pyrrolidines; Receptors, Opioid; Vas Deferens | 1987 |
Roles of central and peripheral mu, delta and kappa opioid receptors in the mediation of gastric acid secretory effects in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Brain; Cyclazocine; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; Gastric Acid; Male; Morphine; Naltrexone; Pyrrolidines; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1988 |
Nor-binaltorphimine, a highly selective kappa-opioid antagonist in analgesic and receptor binding assays.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Guinea Pigs; Male; Mice; Morphine; Naltrexone; Oligopeptides; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa | 1988 |
Kappa receptor regulation of dopamine release from striatum and cortex of rats and guinea pigs.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cerebral Cortex; Corpus Striatum; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Male; Naltrexone; Potassium; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa | 1988 |
Suppression by nor-binaltorphimine of kappa opioid-mediated diuresis in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Diuresis; Dose-Response Relationship, Drug; Male; Morphine; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa | 1988 |
Kappa antagonist properties of buprenorphine in the shock titration procedure.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Buprenorphine; Electroshock; Fentanyl; Male; Naltrexone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Saimiri | 1988 |
Buprenorphine is a potent kappa-opioid receptor antagonist in pigeons and mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Buprenorphine; Columbidae; Male; Mice; Muscle Contraction; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Reinforcement Schedule | 1988 |
Cardiovascular responses to kappa opioid agonists in intact and adrenal demedullated rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenal Medulla; Animals; Benzomorphans; Blood Pressure; Cardiovascular System; Dose-Response Relationship, Drug; Heart Rate; Male; Morphinans; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rats; Rats, Inbred Strains; Tape Recording | 1988 |
Effect of beta-funaltrexamine on opioid side-effects produced by morphine and U-50, 488H.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Body Temperature; Depression, Chemical; Dose-Response Relationship, Drug; Gastrointestinal Motility; Hypnotics and Sedatives; Male; Morphine; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rats; Rats, Inbred Strains; Respiration | 1985 |
Binaltorphimine and nor-binaltorphimine, potent and selective kappa-opioid receptor antagonists.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Chemical Phenomena; Chemistry; Cyclazocine; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Male; Mice; Morphine; Naloxone; Naltrexone; Pyrrolidines; Rabbits; Receptors, Opioid; Receptors, Opioid, kappa | 1987 |
TENA, a selective kappa opioid receptor antagonist.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Azocines; Benzomorphans; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Ileum; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vas Deferens | 1985 |
Effect of mu and kappa opioid receptor agonists on rat plasma corticosterone levels.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Benzomorphans; Corticosterone; Dose-Response Relationship, Drug; Fentanyl; Male; Morphine; Naloxone; Naltrexone; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1985 |
Reversal by beta-funaltrexamine of the antinociceptive effect of opioid agonists in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Buprenorphine; Cyclazocine; Ethylketocyclazocine; Fentanyl; Male; Naltrexone; Pain; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1986 |
Irreversible selective blockade of kappa-opioid receptors in the guinea-pig ileum.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Diuresis; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine Derivatives; Naltrexone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa | 1986 |
Use of beta-funaltrexamine to determine mu opioid receptor involvement in the analgesic activity of various opioid ligands.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Biological Assay; Buprenorphine; Butorphanol; Cyclazocine; Dose-Response Relationship, Drug; Ethylketocyclazocine; Etorphine; Fentanyl; Methadone; Mice; Morphine; Muscle Contraction; Nalbuphine; Nalorphine; Naltrexone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, mu | 1987 |
Kappa opioids in rhesus monkeys. II. Analysis of the antagonistic actions of quadazocine and beta-funaltrexamine.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Azocines; Benzomorphans; Cyclazocine; Diuresis; Endorphins; Ethylketocyclazocine; Female; Hot Temperature; Macaca mulatta; Male; Morphine; Naltrexone; Narcotic Antagonists; Pyrrolidines; Reaction Time; Tail | 1987 |
Orally administered opioid antagonists reverse both mu and kappa opioid agonist delay of gastrointestinal transit in the guinea pig.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Gastrointestinal Transit; Guinea Pigs; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1995 |
Characterization of the opioid receptor subtypes mediating the negative inotropic effects of DAMGO, DPDPE and U-50, 488H in isolated human right atria strips.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adult; Aged; Analgesics; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Heart Atria; Humans; Male; Middle Aged; Myocardial Contraction; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pyrrolidines; Receptors, Opioid | 1995 |
Ca2+ channel inhibition by kappa opioid receptors expressed in Xenopus oocytes.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Barium; Calcium Channels; Electric Conductivity; GTP-Binding Proteins; Injections; Naltrexone; Oocytes; Pertussis Toxin; Pyrrolidines; Rats; Receptors, Opioid, kappa; RNA; Virulence Factors, Bordetella; Xenopus laevis | 1994 |
The opioid peptide dynorphin directly blocks NMDA receptor channels in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Dynorphins; In Vitro Techniques; Ion Channels; Naloxone; Naltrexone; Neurons; Patch-Clamp Techniques; Pyrrolidines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa; Structure-Activity Relationship; Trigeminal Nerve | 1995 |
Kappa opioid inhibition of morphine and cocaine self-administration in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Cocaine; Dose-Response Relationship, Drug; Extinction, Psychological; Female; Morphine; Naltrexone; Narcotics; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reinforcement, Psychology; Self Administration | 1995 |
CCB, a novel specific kappa opioid agonist, which discriminates between opioid and sigma 1 recognition sites.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzomorphans; Binding, Competitive; Male; Mice; Morphine; Naltrexone; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa | 1995 |
Inhibition of luteinizing hormone-releasing hormone secretion by delta-opioid agonists in GT1-1 neuronal cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Alprostadil; Amino Acid Sequence; Cell Line; Colforsin; Culture Media, Conditioned; Dinoprostone; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gonadotropin-Releasing Hormone; Molecular Sequence Data; Naltrexone; Narcotic Antagonists; Neurons; Pyrrolidines; Receptors, Opioid, delta | 1995 |
Characterization of irreversible binding of beta-funaltrexamine to the cloned rat mu opioid receptor.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Sequence; Animals; Cell Line; Cloning, Molecular; Diprenorphine; Electrophoresis, Polyacrylamide Gel; Enkephalin, Leucine; Glycosylation; Molecular Sequence Data; Naltrexone; Oligopeptides; Protein Binding; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Proteins; Sodium; Tritium | 1995 |
Mouse strain differences in in vivo and in vitro immunosuppressive effects of opioids.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Erythrocytes; Female; Immunosuppressive Agents; Mice; Mice, Inbred Strains; Morphine; Naloxone; Naltrexone; Opioid Peptides; Pyrrolidines; Species Specificity; Spleen | 1995 |
The modulation of placental lactogen release by opioids: a role for extracellular calcium.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylate Cyclase Toxin; Analgesics; Calcium; Cells, Cultured; Dopamine; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Ethylketocyclazocine; Gene Expression Regulation; Humans; Ionomycin; Naloxone; Naltrexone; Narcotics; Pertussis Toxin; Placental Lactogen; Pyrrolidines; Time Factors; Trophoblasts; Virulence Factors, Bordetella | 1993 |
Differential involvement of ventral tegmental mu, delta and kappa opioid receptors in modulation of basal mesolimbic dopamine release: in vivo microdialysis studies.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; 3,4-Dihydroxyphenylacetic Acid; Amino Acid Sequence; Analgesics; Animals; Chromatography, High Pressure Liquid; Corpus Striatum; Dialysis; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Homovanillic Acid; Hydroxyindoleacetic Acid; Limbic System; Male; Microinjections; Molecular Sequence Data; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Tegmentum Mesencephali | 1993 |
Involvement of kappa-opioid receptor mechanisms in the calcitonin-induced potentiation of opioid effects at the hypothalamus-pituitary-adrenocortical axis.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Calcitonin; Corticosterone; Drug Synergism; Hypothalamo-Hypophyseal System; Male; Morphine; Naltrexone; Narcotics; Pituitary-Adrenal System; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1994 |
Peripheral kappa-opioid receptors mediate the antinociceptive effect of fedotozine (correction of fetodozine) on the duodenal pain reflex inrat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzyl Compounds; Blood Pressure; Dose-Response Relationship, Drug; Duodenum; Injections, Intravenous; Injections, Intraventricular; Male; Morphine; Naloxone; Naltrexone; Pain; Propylamines; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reflex | 1994 |
Kappa opioid receptor agonists suppress absence seizures in WAG/Rij rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Sequence; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electroencephalography; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Epilepsy, Absence; Injections, Intraventricular; Injections, Subcutaneous; Male; Molecular Sequence Data; Naltrexone; Pyrroles; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid, kappa; Receptors, Opioid, mu; Thiophenes | 1995 |
Repeated acquisition of behavioral chains in squirrel monkeys: comparisons of a mu, kappa and delta opioid agonist.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzamides; Conditioning, Operant; Dose-Response Relationship, Drug; Female; Morphine; Naltrexone; Piperazines; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Saimiri | 1995 |
Both T cells and macrophages are targets of kappa-opioid-induced immunosuppression.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Antibody Formation; Cell Separation; Cells, Cultured; Depression, Chemical; Lymphocyte Activation; Lymphocyte Cooperation; Macrophage Activation; Macrophages, Peritoneal; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Naloxone; Naltrexone; Neuroimmunomodulation; Pyrrolidines; Receptors, Opioid, kappa; Rosette Formation; Specific Pathogen-Free Organisms; T-Lymphocytes | 1994 |
Antagonism of the morphine-induced Straub tail reaction by kappa-opioid receptor activation in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Dose-Response Relationship, Drug; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Morphine; Naltrexone; Narcotic Antagonists; Pain Measurement; Pyrrolidines; Receptors, Opioid, kappa | 1993 |
kappa-Opioid receptor-transfected cell lines: modulation of adenylyl cyclase activity following acute and chronic opioid treatments.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Animals; Benzeneacetamides; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Etorphine; GTP-Binding Proteins; Naloxone; Naltrexone; Opioid Peptides; Pertussis Toxin; Pyrrolidines; Receptors, Opioid, kappa; Virulence Factors, Bordetella | 1995 |
The kappa opioid receptor expressed on the mouse R1.1 thymoma cell line down-regulates without desensitizing during chronic opioid exposure.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Benzeneacetamides; Cell Membrane; Down-Regulation; In Vitro Techniques; Mice; Naloxone; Naltrexone; Pertussis Toxin; Pyrrolidines; Receptors, Opioid, kappa; Thymoma; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1995 |
U50,488, a kappa opioid receptor agonist, attenuates cocaine-induced increases in extracellular dopamine in the nucleus accumbens of rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cocaine; Dopamine; Extracellular Space; Female; Naltrexone; Nucleus Accumbens; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa | 1994 |
The kappa-opioid receptor agonist U50,488H induces acute physical dependence in guinea-pigs.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Behavior, Animal; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine Dependence; Motor Activity; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Pyrrolidines; Receptors, Opioid, kappa; Substance Withdrawal Syndrome; Substance-Related Disorders | 1993 |
Blockade of morphine reward through the activation of kappa-opioid receptors in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; 3,4-Dihydroxyphenylacetic Acid; Analgesics; Animals; Apomorphine; Conditioning, Operant; Dopamine; Dynorphins; Homovanillic Acid; Injections, Subcutaneous; Limbic System; Male; Mice; Mice, Inbred Strains; Morphine; Motivation; Naltrexone; Peptide Fragments; Prosencephalon; Pyrrolidines; Receptors, Opioid, kappa; Reward | 1993 |
Comparative effects of intrahippocampal injection of dynorphin A(1-8), dynorphin A(1-13), dynorphin A(1-17), U-50,488H, and dynorphin B on blood pressure and heart rate in spontaneously hypertensive and normotensive Wistar-Kyoto rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Sequence; Animals; Antihypertensive Agents; Blood Pressure; Dynorphins; Heart Rate; Hippocampus; Hypertension; Male; Molecular Sequence Data; Naltrexone; Peptide Fragments; Pyrrolidines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Reference Values | 1994 |
The kappa agonist fedotozine modulates colonic distention-induced inhibition of gastric motility and emptying in dogs.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzyl Compounds; Bretylium Compounds; Catheterization; Colon; Dogs; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Gastric Emptying; Gastrointestinal Motility; Granisetron; Hexamethonium; Male; Naltrexone; Narcotic Antagonists; Propylamines; Pyrrolidines; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reflex; Stomach | 1994 |
Nalorphine as a stimulus in drug discrimination learning: assessment of the role of mu- and kappa-receptor subtypes.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Diprenorphine; Discrimination Learning; Dose-Response Relationship, Drug; Female; Generalization, Stimulus; Nalorphine; Naloxone; Naltrexone; Pyrrolidines; Rats; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1994 |
Morphine reduces the release of met-enkephalin-like material from the rat spinal cord in vivo by acting at delta opioid receptors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Injections, Spinal; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pyrrolidines; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Spinal Cord | 1994 |
Species difference in the modulatory effect of kappa agonist on 5-HT release from ground squirrel and rat hippocampus.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Aging; Animals; Dose-Response Relationship, Drug; Female; Hippocampus; In Vitro Techniques; Male; Naloxone; Naltrexone; Potassium; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Sciuridae; Serotonin; Species Specificity; Tetrodotoxin | 1994 |
Differential binding domains of peptide and non-peptide ligands in the cloned rat kappa opioid receptor.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Sequence; Animals; Base Sequence; Benzeneacetamides; Binding Sites; Binding, Competitive; Cell Line; Chlorocebus aethiops; Cloning, Molecular; Diprenorphine; DNA Primers; Dynorphins; Endorphins; Kinetics; Ligands; Molecular Sequence Data; Naltrexone; Polymerase Chain Reaction; Protein Conformation; Protein Structure, Secondary; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Fusion Proteins; Transfection | 1994 |
Behavioral effects of kappa-opioid-receptor stimulation on neonatal rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Animals, Newborn; Arousal; Behavior, Animal; Body Temperature Regulation; Brain; Dose-Response Relationship, Drug; Female; Male; Motor Activity; Naltrexone; Pain Threshold; Pregnancy; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Social Isolation; Vocalization, Animal | 1994 |
Agonists and antagonists bind to different domains of the cloned kappa opioid receptor.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Base Sequence; Benzeneacetamides; Binding Sites; Cell Line; Chlorocebus aethiops; Cloning, Molecular; Colforsin; Cyclic AMP; Enkephalin, Leucine; Kinetics; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Naloxone; Naltrexone; Oligodeoxyribonucleotides; Protein Structure, Secondary; Pyrrolidines; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, kappa; Recombinant Fusion Proteins; Recombinant Proteins; Transfection | 1994 |
Role of vagal afferents in the antinociception produced by morphine and U-50,488H in the colonic pain reflex in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Blood Pressure; Colon; Injections, Intraventricular; Injections, Spinal; Male; Morphine; Naloxone; Naltrexone; Neurons, Afferent; Pain; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reflex; Vagotomy; Vagus Nerve | 1994 |
Kappa opioid effects on fetal behavior: central administration of U50,488.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Brain; Dose-Response Relationship, Drug; Female; Fetal Movement; Gestational Age; Injections, Intraventricular; Male; Naltrexone; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa | 1994 |
Effect of chronic exposure to naltrexone and opioid selective agonists on G protein mRNA levels in the rat nervous system.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Brain; Cerebral Ventricles; Drug Administration Schedule; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Gene Expression; GTP-Binding Proteins; In Situ Hybridization; Infusions, Parenteral; Male; Naltrexone; Narcotics; Oligonucleotide Probes; Organ Specificity; Pyrrolidines; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1994 |
The use of specific opioid agonists and antagonists to delineate the vagally mediated antinociceptive and cardiovascular effects of intravenous morphine.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analysis of Variance; Animals; Blood Pressure; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Heart Rate; Hexamethonium; Hexamethonium Compounds; Indoles; Injections, Intravenous; Male; Morphinans; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pain; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reference Values; Time Factors; Vagotomy; Vagus Nerve | 1993 |
The kappa opioid receptor expressed on the mouse R1.1 thymoma cell line is coupled to adenylyl cyclase through a pertussis toxin-sensitive guanine nucleotide-binding regulatory protein.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Analgesics; Animals; Cell Membrane; Cyclic AMP; Dynorphins; GTP-Binding Proteins; Mice; Naltrexone; Pertussis Toxin; Pyrrolidines; Receptors, Opioid, kappa; Sensitivity and Specificity; Thymoma; Thymus Neoplasms; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1993 |
Regulatory role of enteric kappa opioid receptors in human colonic motility.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Colon, Sigmoid; Dynorphins; Electric Stimulation; Enkephalin, Leucine; Gastrointestinal Motility; Humans; In Vitro Techniques; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid, kappa | 1993 |
Delta-1 opioid agonist acutely increases hypoxic tolerance.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adaptation, Physiological; Animals; Benzylidene Compounds; Body Temperature; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hypoxia; Male; Mice; Naltrexone; Pyrrolidines; Receptors, Opioid, delta | 1994 |
Hyperalgesic and analgesic actions of morphine, U50-488, naltrexone, and (-)-lobeline in the rat brainstem.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Dose-Response Relationship, Drug; Female; Lobeline; Microinjections; Morphine; Naltrexone; Pain; Pain Measurement; Pyrrolidines; Rats; Rats, Sprague-Dawley; Tegmentum Mesencephali | 1994 |
Interactions between delta 9-tetrahydrocannabinol and kappa opioids in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzofurans; Dronabinol; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Mice, Inbred ICR; Naltrexone; Pyrrolidines; Receptors, Opioid, kappa | 1994 |
Area tempestas modulates the behavioural responses to nociceptive stimuli in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Anticonvulsants; Azocines; Bicuculline; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Escape Reaction; Foot; Hot Temperature; Male; Morphine; Naltrexone; Narcotic Antagonists; Olfactory Pathways; Pain; Phenazocine; Pressure; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid; Seizures; Tail | 1993 |
Central kappa opioid receptor-evoked changes in renal function in conscious rats: participation of renal nerves.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Diuresis; Glomerular Filtration Rate; Heart Rate; Kidney; Male; Naltrexone; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sympathetic Nervous System | 1993 |
Discriminative-stimulus effects of the low efficacy mu agonist nalbuphine.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Discrimination, Psychological; Dose-Response Relationship, Drug; Ethylketocyclazocine; Male; Nalbuphine; Nalorphine; Naltrexone; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Self Administration | 1993 |
Naloxone-induced analgesia: involvement of kappa-opiate receptors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics; Animals; Benzomorphans; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pain Threshold; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1993 |
Kappa opioid antagonist effects of systemically administered nor-binaltorphimine in a thermal antinociception assay in rhesus monkeys.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetamides; Analgesics; Animals; Benzomorphans; Dose-Response Relationship, Drug; Female; Heating; Macaca mulatta; Naltrexone; Nociceptors; Pain Measurement; Pyrrolidines; Receptors, Opioid, kappa; Time Factors | 1993 |
Ultrasonic vocalizations are elicited from rat pups in the home cage by pentylenetetrazol and U50,488, but not naltrexone.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Animals, Newborn; Arousal; Body Temperature Regulation; Dose-Response Relationship, Drug; Female; Male; Motor Activity; Naltrexone; Pentylenetetrazole; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, kappa; Social Environment; Social Isolation; Ultrasonics; Vocalization, Animal | 1993 |
Neurophysiological evidence for increased kappa opioidergic control of spinal cord neurons in rats with unilateral inflammation at the ankle.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Arthritis, Experimental; Freund's Adjuvant; Inflammation; Joints; Male; Naltrexone; Neurons; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, kappa; Reference Values; Spinal Cord; Stress, Mechanical | 1993 |
Effect of diabetes on the antinociceptive effect of beta-endorphin.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; beta-Endorphin; Cerebral Ventricles; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Pain; Pyrrolidines; Reference Values | 1993 |
Relationship between kappa 1 opioid receptor binding and inhibition of adenylyl cyclase in guinea pig brain membranes.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylyl Cyclase Inhibitors; Animals; Benzeneacetamides; Binding Sites; Cerebellum; Dose-Response Relationship, Drug; Guinea Pigs; Hippocampus; Naltrexone; Pyrrolidines; Receptors, Opioid, kappa | 1993 |
Opioid agonist properties of two oxime derivatives of naltrexone, NPC 831 and NPC 836.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetates; Analgesics; Animals; Binding, Competitive; Bombesin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Ligands; Male; Mice; Naltrexone; Oximes; Pain; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid; Receptors, Opioid, kappa | 1993 |
The kappa opioid agonist U-50,488H antagonizes respiratory effects of mu opioid receptor agonists in conscious rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Morphine; Naltrexone; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Respiration | 1993 |
Effects of dopamine and kappa opioid receptors on fetal responsiveness to perioral stimuli.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzazepines; Brain; Dopamine; Dose-Response Relationship, Drug; Female; Fetal Movement; Naltrexone; Pregnancy; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Opioid, kappa; Stereotyped Behavior; Sucking Behavior | 1993 |
The actions of the kappa 1 opioid agonist U-50,488 on presynaptic nerve terminals of the chick ciliary ganglion.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Animals, Newborn; Chickens; Electrophysiology; Ganglia, Parasympathetic; In Vitro Techniques; Membrane Potentials; Naltrexone; Nerve Endings; Potassium Channels; Pyrrolidines; Receptors, Opioid, kappa; Sodium Channels; Synapses | 1993 |
Anticonvulsant effects of U-54494A and U-50488H in genetically epilepsy-prone rats and DBA/2 mice: a possible involvement of glycine/NMDA receptor complex.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Anticonvulsants; Epilepsy; Female; Male; Mice; Mice, Inbred DBA; Motor Activity; Naloxone; Naltrexone; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Opioid, kappa; Serine | 1993 |
Spinal delta 2 but not delta 1 opioid receptors are involved in intracerebroventricular beta-endorphin-induced antinociception in the mouse.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzylidene Compounds; beta-Endorphin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Nociceptors; Pain Measurement; Pyrrolidines; Receptors, Opioid, delta; Spinal Cord | 1993 |
Effects of the kappa-opioid agonist U50,488 on parturition in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Female; Infusions, Intravenous; Injections, Intravenous; Labor, Obstetric; Male; Morphine; Naloxone; Naltrexone; Oxytocin; Pregnancy; Pyrrolidines; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Opioid, kappa; Uterine Contraction | 1993 |
Withdrawal contractures of guinea-pig isolated ileum after acute activation of kappa-opioid receptors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Clonidine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Nifedipine; Pyrrolidines; Receptors, Opioid, kappa; Substance Withdrawal Syndrome | 1993 |
Blockade of cannabinoid-induced antinociception by norbinaltorphimine, but not N,N-diallyl-tyrosine-Aib-phenylalanine-leucine, ICI 174,864 or naloxone in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Dronabinol; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Infusions, Intravenous; Injections, Spinal; Mice; Naloxone; Naltrexone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta | 1993 |
Opioid control of the release of calcitonin gene-related peptide-like material from the rat spinal cord in vivo.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Calcitonin Gene-Related Peptide; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Spinal; Iodine Radioisotopes; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pyrrolidines; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1993 |
Effects of kappa-agonist on the antinociception and locomotor enhancing action induced by morphine in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzylamines; Dopamine; Dose-Response Relationship, Drug; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Narcotics; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sympathomimetics | 1993 |
Kappa opioid receptor-mediated regulation of prolactin and alpha-melanocyte-stimulating hormone secretion in male and female rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; alpha-MSH; Animals; Female; Male; Naltrexone; Prolactin; Pyrrolidines; Rats; Receptors, Opioid, kappa; Sex Characteristics; Sex Factors; Time Factors | 1993 |
Selective and interactive down-regulation of mu- and delta-opioid receptors in human neuroblastoma SK-N-SH cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Down-Regulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Humans; Morphine; Naltrexone; Neuroblastoma; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, mu; Tumor Cells, Cultured | 1993 |
Antitussive effects of mu- and kappa-agonists in diabetic rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Antitussive Agents; Diabetes Mellitus, Experimental; Male; Morphine; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1993 |
Chronic kappa opioid receptor antagonism produces supersensitivity to U-50,488H at the hypothalamo-pituitary-adrenocortical (HPA) axis level.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Body Weight; Corticosterone; Dose-Response Relationship, Drug; Hyperalgesia; Hypothalamo-Hypophyseal System; Male; Naloxone; Naltrexone; Pituitary-Adrenal System; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Sensitivity and Specificity; Sodium Chloride | 1993 |
U-50,488H, a kappa-opioid receptor agonist, markedly prevents memory dysfunctions induced by transient cerebral ischemia in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amnesia; Analgesics; Animals; Avoidance Learning; Body Temperature; Drug Interactions; Ischemic Attack, Transient; Learning; Male; Memory; Mice; Mice, Inbred Strains; Naltrexone; Pyrrolidines; Receptors, Opioid, kappa; Reperfusion; Time Factors | 1993 |
Evidence for the up-regulation of kappa opiate mechanisms in mice selectively bred for high analgesia.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics; Animals; Female; Mice; Morphine; Naltrexone; Pyrrolidines; Receptors, Opioid, kappa; Stress, Psychological; Swimming; Up-Regulation | 1993 |
A comparison of YM-14673, U-50488H, and nalmefene after spinal cord injury in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Azetidines; Dipeptides; Female; Naltrexone; Narcotic Antagonists; Nervous System; Pyrrolidines; Rats; Rats, Sprague-Dawley; Spinal Cord Injuries | 1993 |
kappa-Opioid receptor agonists prevent sensitization to the conditioned rewarding effects of cocaine.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzeneacetamides; Cocaine; Conditioning, Psychological; Dopamine; Male; Naltrexone; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reward | 1996 |
Opioid antagonist profile of SC nor-binaltorphimine in the formalin paw assay.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Formaldehyde; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Pyrroles; Pyrrolidines; Receptors, Opioid, kappa; Receptors, Opioid, mu; Thiophenes | 1996 |
Estrogen and progesterone activate spinal kappa-opiate receptor analgesic mechanisms.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics; Animals; Estrogens; Female; Naltrexone; Narcotic Antagonists; Nociceptors; Pain Threshold; Progesterone; Pseudopregnancy; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Spinal Cord | 1996 |
Induction of Fos-like immunoreactivity by opioids in guinea-pig brain.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Opioid; Animals; Brain Chemistry; Diencephalon; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Guinea Pigs; Immunohistochemistry; Injections, Intraventricular; Male; Mesencephalon; Morphine; Naltrexone; Narcotic Antagonists; Neurons; Proto-Oncogene Proteins c-fos; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Telencephalon | 1996 |
Evidence that D2 receptor-mediated activation of hypothalamic tuberoinfundibular dopaminergic neurons in the male rat occurs via inhibition of tonically active afferent dynorphinergic neurons.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; 3,4-Dihydroxyphenylacetic Acid; Afferent Pathways; Analgesics; Animals; Cerebral Ventricles; Dihydroxyphenylalanine; Dopa Decarboxylase; Dopamine; Dopamine Agonists; Dynorphins; Hypothalamus; Hypothalamus, Middle; Injections, Intraperitoneal; Injections, Intraventricular; Limbic System; Male; Median Eminence; Naltrexone; Narcotic Antagonists; Neurons; Nucleus Accumbens; Prolactin; Pyrrolidines; Quinolines; Rats; Receptors, Dopamine D2; Receptors, Opioid, kappa | 1996 |
Systemic administration of dynorphin A-(1-13) markedly improves cycloheximide-induced amnesia in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amnesia; Analgesics; Animals; Avoidance Learning; Cycloheximide; Dynorphins; Injections, Intraventricular; Male; Memory; Mice; Naltrexone; Narcotic Antagonists; Protein Synthesis Inhibitors; Pyrrolidines; Quaternary Ammonium Compounds; Receptors, Opioid, kappa | 1996 |
kappa-opioid receptor expression defines a phenotypically distinct subpopulation of astroglia: relationship to Ca2+ mobilization, development, and the antiproliferative effect of opioids.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Astrocytes; Benzeneacetamides; Bromodeoxyuridine; Calcium; Calcium Channel Blockers; Cell Count; Cell Division; Cells, Cultured; DNA; Enzyme Inhibitors; Gene Expression Regulation, Developmental; Immunohistochemistry; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Nifedipine; Phenotype; Pyrrolidines; Receptors, Opioid, kappa; Thapsigargin; Time Factors | 1996 |
Opioid receptor-mediated control of acetylcholine release in human neocortex tissue.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetylcholine; Adolescent; Adult; Aged; Analgesics; Analysis of Variance; Baclofen; Cerebral Cortex; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; GABA Agonists; Humans; Male; Middle Aged; Muscimol; Naloxone; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid, delta; Tetrodotoxin | 1996 |
Gastric effects of mu-, delta- and kappa-opioid receptor agonists on brainstem unitary responses in the neonatal rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Animals, Newborn; Brain Stem; Drug Interactions; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Solitary Nucleus; Stomach | 1996 |
U-50488H, a selective kappa-opioid receptor agonist, improves carbon monoxide-induced delayed amnesia in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amnesia; Analgesics; Animals; Avoidance Learning; Carbon Monoxide Poisoning; Electric Stimulation; Male; Mice; Naltrexone; Narcotic Antagonists; Pyrrolidines | 1996 |
Inhibition of lipopolysaccharide-induced nitric oxide and cytokine production by ultralow concentrations of dynorphins in mixed glia cultures.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cells, Cultured; Dynorphins; Lipopolysaccharides; Mice; Naltrexone; Neuroglia; Nitric Oxide; Peptide Fragments; Pyrrolidines; Tumor Necrosis Factor-alpha | 1997 |
Reversal by kappa-agonists of peritoneal irritation-induced ileus and visceral pain in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetic Acid; Analgesics; Animals; Benzofurans; Benzomorphans; Cyclazocine; Fentanyl; Gastric Emptying; Intestinal Pseudo-Obstruction; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Peritoneum; Pyrroles; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Thiophenes | 1997 |
Nalbuphine coadministered with morphine prevents tolerance and dependence.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Therapy, Combination; Drug Tolerance; Male; Morphine; Nalbuphine; Naloxone; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Pyrrolidines; Rats; Rats, Sprague-Dawley | 1997 |
Participation of central kappa-opioid receptor in arrhythmogenesis.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Arrhythmias, Cardiac; Dynorphins; Epinephrine; Hexamethonium; Male; Naloxone; Naltrexone; Narcotic Antagonists; Peptide Fragments; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, kappa | 1997 |
Effects of kappa opioids on cocaine self-administration by rhesus monkeys.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Circadian Rhythm; Cocaine; Dose-Response Relationship, Drug; Ethylketocyclazocine; Female; Macaca mulatta; Male; Naloxone; Naltrexone; Pyrrolidines; Receptors, Opioid, kappa; Self Administration; Substance-Related Disorders | 1997 |
Supraspinal administration of opioids with selectivity for mu-, delta- and kappa-opioid receptors produces analgesia in amphibians.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Benzofurans; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Female; Fentanyl; Injections, Intraventricular; Male; Morphine; Naltrexone; Narcotics; Pyrrolidines; Rana pipiens; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1997 |
Effect of enterostatin and kappa-opioids on macronutrient selection and consumption.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Butorphanol; Colipases; Dietary Carbohydrates; Dietary Fats; Eating; Enzyme Precursors; Food Preferences; Male; Naltrexone; Narcotic Antagonists; Narcotics; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa | 1997 |
Butorphanol-mediated antinociception in mice: partial agonist effects and mu receptor involvement.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Butorphanol; Male; Mice; Morphine; Naltrexone; Pyrrolidines; Receptors, Opioid, mu | 1997 |
Antinociceptive effects of morphine and U-50,488H on vaginal distension in the anesthetized rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia; Animals; Blood Pressure; Cardiovascular System; Estrus; Female; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vaginal Diseases | 1997 |
Anatomical distribution of mu, delta, and kappa opioid- and nociceptin/orphanin FQ-stimulated [35S]guanylyl-5'-O-(gamma-thio)-triphosphate binding in guinea pig brain.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Non-Narcotic; Animals; Autoradiography; Brain Chemistry; Cerebellum; Diencephalon; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Male; Medulla Oblongata; Mesencephalon; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptin; Opioid Peptides; Pons; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sulfur Radioisotopes; Telencephalon | 1997 |
Differential response to kappa-opioidergic agents in dietary fat selection between Osborne-Mendel and S5B/P1 rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Brain; Diet; Dietary Fats; Eating; Energy Metabolism; Food Preferences; Male; Naltrexone; Narcotic Antagonists; Narcotics; Obesity; Rats; Rats, Inbred Strains; Receptors, Opioid, kappa | 1998 |
Suppression of cAMP by phosphoinositol/Ca2+ pathway in the cardiac kappa-opioid receptor.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylate Cyclase Toxin; Animals; Calcimycin; Calcium; Cells, Cultured; Chelating Agents; Colforsin; Cyclic AMP; Egtazic Acid; Heart; Heart Ventricles; Kinetics; Male; Myocardium; Naltrexone; Narcotic Antagonists; Pertussis Toxin; Phosphatidylinositols; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Signal Transduction; Virulence Factors, Bordetella | 1998 |
U50,488H inhibits effects of norepinephrine in rat cardiomyocytes-cross-talk between kappa-opioid and beta-adrenergic receptors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic beta-Agonists; Animals; Bucladesine; Calcium; Colforsin; Electric Stimulation; GTP-Binding Proteins; In Vitro Techniques; Intracellular Fluid; Myocardial Contraction; Myocardium; Naltrexone; Norepinephrine; Pertussis Toxin; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; Receptors, Opioid, kappa; Type C Phospholipases; Virulence Factors, Bordetella | 1998 |
Establishing morphine and U-50,488H as discriminative stimuli in a three-choice assay with pigeons.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Columbidae; Dextroamphetamine; Discrimination Learning; Discrimination, Psychological; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Ethylketocyclazocine; Generalization, Response; Morphine; Naltrexone; Narcotic Antagonists; Narcotics | 1998 |
Receptor-mediated activation of G-proteins by kappa opioid agonists in frog (Rana esculenta) brain membranes.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzomorphans; Brain; Cell Membrane; Ethylketocyclazocine; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Kinetics; Naltrexone; Narcotic Antagonists; Rana esculenta; Receptors, Opioid, kappa | 1998 |
Comparative hypotensive actions of three nonpeptide kappa opioid agonists on hippocampus of SHRs and normotensive WKY rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Antihypertensive Agents; Benzomorphans; Dose-Response Relationship, Drug; Hippocampus; Male; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Opioid, kappa | 1998 |
Dynorphin uses a non-opioid mechanism to potentiate N-methyl-D-aspartate currents in single rat periaqueductal gray neurons.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Action Potentials; Analgesics, Non-Narcotic; Animals; Drug Synergism; Dynorphins; N-Methylaspartate; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Patch-Clamp Techniques; Peptide Fragments; Periaqueductal Gray; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa | 1998 |
Involvement of mu- and delta-opioid receptors in the ethanol-associated place preference in rats exposed to foot shock stress.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Ethanol; Exploratory Behavior; Foot; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Morphine; Naloxone; Naltrexone; Narcotics; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu | 1998 |
Kappa-opioid potentiation of tumor necrosis factor-alpha-induced anti-HIV-1 activity in acutely infected human brain cell cultures.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Antiviral Agents; Brain; Cells, Cultured; Drug Synergism; HIV-1; Humans; Interleukin-1; Naltrexone; Receptors, Opioid, kappa; Tumor Necrosis Factor-alpha | 1998 |
Relationship between inhibitory effect of endogenous opioid via mu-receptors and muscarinic autoinhibition in acetylcholine release from myenteric plexus of guinea pig ileum.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetylcholine; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Atropine; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphinans; Muscarine; Muscarinic Agonists; Muscarinic Antagonists; Muscle, Smooth; Myenteric Plexus; Naltrexone; Narcotic Antagonists; Opioid Peptides; Receptors, Muscarinic; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1998 |
Renal excretory responses produced by the delta opioid agonist, BW373U86, in conscious rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzamides; Denervation; Infusions, Intravenous; Kidney; Male; Naltrexone; Oligopeptides; Opioid Peptides; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta | 1998 |
MU-opioid receptor-knockout mice: role of mu-opioid receptor in morphine mediated immune functions.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Binding, Competitive; Disease Models, Animal; Drug Implants; Exons; Gene Targeting; Immune System; Immunosuppression Therapy; Interleukin-2; Ligands; Macrophage Activation; Macrophages, Peritoneal; Mice; Mice, Knockout; Mitogens; Morphine; Naltrexone; Organ Size; Phagocytosis; Receptors, Opioid, mu; Spleen; Substance-Related Disorders; Thymidine; Thymus Gland; Tumor Necrosis Factor-alpha | 1998 |
Inhibition of the neuronal nicotinic receptor-mediated current by kappa opioid receptor agonists in PC12 cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Dynorphins; Electric Conductivity; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Naltrexone; Narcotic Antagonists; Neurons; Nicotinic Antagonists; PC12 Cells; Rats; Receptors, Nicotinic; Receptors, Opioid, kappa | 1998 |
Phospholipase C inhibitors attenuate arrhythmias induced by kappa-receptor stimulation in the isolated rat heart.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Arrhythmias, Cardiac; Calcium; Enzyme Inhibitors; Estrenes; Heart Rate; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Male; Naltrexone; Narcotic Antagonists; Neomycin; Pertussis Toxin; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Signal Transduction; Streptomycin; Type C Phospholipases; Virulence Factors, Bordetella | 1998 |
kappa-opioid regulation of neuronal activity in the rat supraoptic nucleus in vivo.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Cells, Cultured; Dendrites; Down-Regulation; Dynorphins; Electrophysiology; Female; Injections, Intravenous; Membrane Potentials; Microdialysis; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Oxytocin; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Supraoptic Nucleus; Vasopressins | 1998 |
Activation of peripheral kappa opioid receptors inhibits capsaicin-induced thermal nociception in rhesus monkeys.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Azocines; Benzomorphans; Capsaicin; Dynorphins; Female; Hot Temperature; Ligands; Macaca mulatta; Male; Naltrexone; Narcotic Antagonists; Pain Measurement; Peptide Fragments; Receptors, Opioid, kappa | 1999 |
Effects of U50488 and bremazocine on [Ca2+]i and cAMP in naive and tolerant rat ventricular myocytes: evidence of kappa opioid receptor multiplicity in the heart.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Azocines; Benzomorphans; Calcium; Cells, Cultured; Colforsin; Cyclic AMP; Drug Resistance; Electric Stimulation; Heart; Heart Ventricles; Male; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa | 1999 |
Different roles of mu-, delta- and kappa-opioid receptors in ethanol-associated place preference in rats exposed to conditioned fear stress.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Behavior, Animal; Central Nervous System Depressants; Conditioning, Psychological; Ethanol; Fear; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stress, Psychological | 1999 |
Immunomodulatory action of class mu-, delta- and kappa-opioid receptor agonists in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Immunity; Lymphocyte Activation; Male; Mice; Mice, Inbred C57BL; Mitogens; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; T-Lymphocytes | 1998 |
Opioidergic modulation of voltage-activated K+ currents in magnocellular neurons of the supraoptic nucleus in rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Ion Channel Gating; Membrane Potentials; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Patch-Clamp Techniques; Potassium Channels; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Supraoptic Nucleus | 1999 |
Bremazocine reduces unrestricted free-choice ethanol self-administration in rats without affecting sucrose preference.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Alcohol Drinking; Alcoholism; Animals; Benzomorphans; Ethanol; Male; Motor Activity; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid; Reinforcement, Psychology; Self Administration; Sucrose | 1999 |
Gastric effects of methylnaltrexone on mu, kappa, and delta opioid agonists induced brainstem unitary responses.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Animals, Newborn; Brain Stem; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Morphine; Naltrexone; Narcotic Antagonists; Neurons; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Solitary Nucleus; Stomach; Vagus Nerve | 1999 |
Analgesia-producing mechanism of processed Aconiti tuber: role of dynorphin, an endogenous kappa-opioid ligand, in the rodent spinal cord.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Administration, Topical; Analgesics; Animals; Arcuate Nucleus of Hypothalamus; Cold Temperature; Dexamethasone; Dopamine Antagonists; Drugs, Chinese Herbal; Dynorphins; Glucocorticoids; Hypothalamus; Immune Sera; Ligands; Male; Mice; Naltrexone; Narcotic Antagonists; Nociceptors; Pain; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Salicylamides; Spinal Cord; Sulpiride | 1999 |
Cardioprotection of preconditioning by metabolic inhibition in the rat ventricular myocyte. Involvement of kappa-opioid receptor.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Calcium; Cell Survival; Electrophysiology; Energy Metabolism; Heart Ventricles; In Vitro Techniques; Ischemic Preconditioning, Myocardial; Membrane Potentials; Muscle Fibers, Skeletal; Myocardial Contraction; Myocardial Ischemia; Myocardium; Naltrexone; Narcotic Antagonists; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Trypan Blue | 1999 |
Kappa opioid receptor agonists differentially inhibit two classes of rat spinal neurons excited by colorectal distention.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzyl Compounds; Colon; Male; Naltrexone; Propylamines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Rectum; Spinal Cord | 1999 |
Interactions between cholecystokinin and opioids in the isolated guinea-pig ileum.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphinans; Muscle Contraction; Naloxone; Naltrexone; Oligopeptides; Opioid Peptides; Receptor, Cholecystokinin A; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Receptors, Opioid; Sincalide; Substance Withdrawal Syndrome | 1999 |
Differential antagonism of the rate-decreasing effects of kappa-opioid receptor agonists by naltrexone and norbinaltorphimine.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Behavior, Animal; Benzeneacetamides; Benzofurans; Benzomorphans; Conditioning, Operant; Dose-Response Relationship, Drug; Ethylketocyclazocine; Nalorphine; Naltrexone; Narcotic Antagonists; Pyrroles; Pyrrolidines; Receptors, Opioid, kappa; Reinforcement Schedule; Saimiri; Thiophenes | 1999 |
Anti-arrhythmic effect of kappa-opioid receptor stimulation in the perfused rat heart: involvement of a cAMP-dependent pathway.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic beta-Antagonists; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium; Colforsin; Cyclic AMP; Cytosol; Electric Stimulation; Electrocardiography; Heart; Heart Rate; In Vitro Techniques; Male; Myocardial Contraction; Naltrexone; Norepinephrine; Propranolol; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa | 1999 |
Hyperalgesic response to noxious stimulation in genetically polydipsic mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Drinking; Drinking Behavior; Hot Temperature; Hyperalgesia; Locomotion; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred Strains; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Nociceptors; Pain Measurement; Reaction Time; Water Deprivation | 1999 |
Intracisternal nor-binaltorphimine distinguishes central and peripheral kappa-opioid antinociception in rhesus monkeys.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Opioid; Animals; Benzomorphans; Central Nervous System; Cisterna Magna; Dose-Response Relationship, Drug; Female; Hot Temperature; Injections; Macaca mulatta; Male; Naltrexone; Narcotic Antagonists; Peripheral Nervous System; Receptors, Opioid, kappa | 1999 |
Identification of the G-protein-coupled ORL1 receptor in the mouse spinal cord by [35S]-GTPgammaS binding and immunohistochemistry.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Atropine; Autoradiography; Baclofen; Binding, Competitive; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Haloperidol; Immunohistochemistry; In Vitro Techniques; Male; Membranes; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Nociceptin; Nociceptin Receptor; Opioid Peptides; Peptide Fragments; Propranolol; Receptors, Opioid; Somatostatin; Spinal Cord; Sulfur Radioisotopes; Yohimbine | 1999 |
ATP-gated K(+) channel openers enhance opioid antinociception: indirect evidence for the release of endogenous opioid peptides.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenosine Triphosphate; Analgesics; Animals; Cromakalim; Diazoxide; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Glyburide; Injections, Intraventricular; Ion Channel Gating; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Narcotic Antagonists; Nociceptors; Opioid Peptides; Pain; Potassium Channels; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin | 1999 |
kappa-Opioid receptors in the substantia nigra pars reticulata mediate the U-50,488-induced locomotor activity of preweanling rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Animals, Newborn; Behavior, Animal; Dose-Response Relationship, Drug; Female; Male; Microinjections; Motor Activity; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid, kappa; Substantia Nigra | 2000 |
U50,488 protection against HIV-1-related neurotoxicity: involvement of quinolinic acid suppression.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; AIDS Dementia Complex; Brain; Cells, Cultured; Cerebral Cortex; Fetus; HIV Core Protein p24; HIV-1; Humans; Microglia; Naltrexone; Narcotic Antagonists; Neuroprotective Agents; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa | 2000 |
Kappa-opioid receptor stimulation increases the expression of Na+-H+ exchange gene in the heart.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Gene Expression Regulation; Hydrogen-Ion Concentration; Male; Myocardium; Naltrexone; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Sodium-Hydrogen Exchangers | 2000 |
Changes in analgesia-producing mechanism of repeated cold stress loading in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Anti-Anxiety Agents; Anxiety; Cold Temperature; Diazepam; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Pain Threshold; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stress, Physiological | 2000 |
Mechanical activation of dorsal root ganglion cells in vitro: comparison with capsaicin and modulation by kappa-opioids.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amiloride; Animals; Benzyl Compounds; Calcium; Capsaicin; Cells, Cultured; Gadolinium; Ganglia, Spinal; In Vitro Techniques; Kinetics; Male; Naltrexone; Neurons; Physical Stimulation; Propylamines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa | 2000 |
Modulatory effect of endogenous and exogenous opioids on the excitatory reflex pathway of the rat ileum.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Ileum; In Vitro Techniques; Male; Morphine; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Narcotics; Peristalsis; Rats; Rats, Wistar; Receptors, Opioid; Somatostatin | 2000 |
Activation of c-fos expression in hypothalamic nuclei by mu- and kappa-receptor agonists: correlation with catecholaminergic activity in the hypothalamic paraventricular nucleus.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Male; Methoxyhydroxyphenylglycol; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Norepinephrine; Paraventricular Hypothalamic Nucleus; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Suprachiasmatic Nucleus; Supraoptic Nucleus | 2000 |
Effects of differential modulation of mu-, delta- and kappa-opioid systems on bicuculline-induced convulsions in the mouse.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Bicuculline; Brain Chemistry; Convulsants; Enkephalin, D-Penicillamine (2,5)-; Epilepsy, Tonic-Clonic; Injections, Intraventricular; Injections, Subcutaneous; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Quinolines; Receptors, GABA-A; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Seizures; Synaptic Transmission | 2000 |
Altered opioid-mediated control of the spinal release of dynorphin and met-enkephalin in polyarthritic rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia; Animals; Arthritis; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Iodine Radioisotopes; Ligands; Male; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 2000 |
Kappa-opioid receptor modulation of nicotine-induced behaviour.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Behavior, Animal; Benzeneacetamides; Benzofurans; Dose-Response Relationship, Drug; Injections, Intraventricular; Male; Motor Activity; Naltrexone; Nicotine; Nicotinic Agonists; Pyrrolidines; Rats; Receptors, Opioid, kappa | 2000 |
Spinal kappa-opioid system plays an important role in suppressing morphine withdrawal syndrome in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Male; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid, kappa; Substance Withdrawal Syndrome | 2000 |
Dose- and time-dependent bimodal effects of kappa-opioid agonists on locomotor activity in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetamides; Animals; Benzomorphans; Dose-Response Relationship, Drug; Isothiocyanates; Male; Mice; Morphine; Motor Activity; Naloxone; Naltrexone; Receptors, Opioid, kappa; Time Factors | 2000 |
delta-, but not mu- and kappa-, opioid receptor activation protects neocortical neurons from glutamate-induced excitotoxic injury.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Cells, Cultured; Cytoprotection; Embryo, Mammalian; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Excitatory Amino Acid Agonists; Female; Glutamic Acid; L-Lactate Dehydrogenase; Naltrexone; Narcotic Antagonists; Neocortex; Neurons; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2000 |
The selective kappa-opioid receptor agonist U50,488H attenuates voluntary ethanol intake in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Alcohol Drinking; Animals; Central Nervous System Depressants; Depression, Chemical; Drinking; Ethanol; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Lew; Receptors, Opioid, kappa | 2001 |
Place aversion induced by blockade of mu or activation of kappa opioid receptors in the dorsal periaqueductal gray matter.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analysis of Variance; Animals; Behavior, Animal; Conditioning, Operant; Dose-Response Relationship, Drug; Male; Morphine; Naltrexone; Periaqueductal Gray; Rats; Rats, Wistar; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin | 2000 |
Ultrasonic vocalizations of preweanling rats: involvement of both alpha(2)-adrenoceptor and kappa-opioid receptor systems.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics, Non-Narcotic; Animals; Animals, Newborn; Animals, Suckling; Clonidine; Female; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Opioid, kappa; Vocalization, Animal; Yohimbine | 2001 |
TRK-820, a selective kappa-opioid agonist, produces potent antinociception in cynomolgus monkeys.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Behavior, Animal; Macaca fascicularis; Morphinans; Morphine; Naloxone; Naltrexone; Pain Measurement; Pentazocine; Pentobarbital; Receptors, Opioid, kappa; Spiro Compounds | 2001 |
Norbinaltorphimine, a selective kappa-opioid receptor antagonist, induces an itch-associated response in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Antipruritics; Behavior, Animal; Chlorpheniramine; Dose-Response Relationship, Drug; Histamine H1 Antagonists; Injections, Subcutaneous; Mice; Mice, Inbred ICR; Naltrexone; p-Methoxy-N-methylphenethylamine; Pruritus; Receptors, Opioid, kappa | 2001 |
Inducible HSP70 mediates delayed cardioprotection via U-50488H pretreatment in rat ventricular myocytes.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Heart; Heart Ventricles; HSP70 Heat-Shock Proteins; Ischemic Preconditioning, Myocardial; L-Lactate Dehydrogenase; Male; Myocardial Ischemia; Myocardium; Naltrexone; Narcotic Antagonists; Oligonucleotides, Antisense; Protective Agents; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa | 2001 |
The kappa-opioid antagonist GNTI reduces U50,488-, DAMGO-, and deprivation-induced feeding, but not butorphanol- and neuropeptide Y-induced feeding in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Brain; Butorphanol; Drug Interactions; Eating; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Food Deprivation; Guanidines; Male; Morphinans; Naltrexone; Narcotic Antagonists; Narcotics; Neuropeptide Y; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa | 2001 |
Kappa-opioid receptors on lymphocytes of a human lymphocytic cell line: morphine-induced up-regulation as evidenced by competitive RT-PCR and indirect immunofluorescence.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Cell Line; Fluorescent Antibody Technique, Indirect; Humans; Lymphocytes; Morphine; Naltrexone; Narcotic Antagonists; Receptors, Opioid, kappa; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Up-Regulation | 2001 |
Administration of mu-, kappa- or delta2-receptor agonists via osmotic minipumps suppresses murine splenic antibody responses.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Antibody Formation; Depression, Chemical; Dose-Response Relationship, Drug; Female; Immunosuppressive Agents; Infusion Pumps; Mice; Mice, Inbred C3H; Morphine; Naltrexone; Neuroimmunomodulation; Oligopeptides; Osmosis; Peptide Fragments; Peptides; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin; Spleen | 2001 |
Naloxone fails to produce conditioned place aversion in mu-opioid receptor knock-out mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Avoidance Learning; Brain; Conditioning, Psychological; Dose-Response Relationship, Drug; Habituation, Psychophysiologic; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Opioid Peptides; Phenotype; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Synaptic Transmission | 2001 |
Effect of opioids on oral Salmonella infection and immune function.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Drug Implants; Female; Immunosuppressive Agents; Infusion Pumps, Implantable; Mice; Mice, Inbred C3H; Morphine; Mouth Diseases; Naltrexone; Narcotic Antagonists; Narcotics; Oligopeptides; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Salmonella Infections, Animal; Salmonella typhimurium | 2001 |
Delta opioid inhibition of light-induced phase advances in hamster circadian activity rhythms.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzamides; Biological Clocks; Circadian Rhythm; Cricetinae; Enkephalins; Light; Male; Mesocricetus; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Nerve Tissue Proteins; Opioid Peptides; Piperazines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Suprachiasmatic Nucleus | 2002 |
Expression of functional kappa-opioid receptors on murine dendritic cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Antigen Presentation; Dendritic Cells; Dynorphins; Gene Expression; Histocompatibility Antigens Class II; In Vitro Techniques; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Naltrexone; Narcotic Antagonists; Neuroimmunomodulation; Phenotype; Receptors, Opioid, kappa; RNA, Messenger | 2002 |
Effect of prodynorphin-derived opioid peptides on the ovulatory luteinizing hormone surge in the proestrous rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Brain; Dynorphins; Enkephalins; Female; Luteinizing Hormone; Naltrexone; Ovulation; Peptide Fragments; Proestrus; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa | 2002 |
Lack of the nociceptin receptor does not affect acute or chronic nociception in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Female; Male; Mice; Mice, Knockout; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptin; Nociceptin Receptor; Oligopeptides; Opioid Peptides; Pain; Receptors, Opioid; Time Factors; Vas Deferens | 2002 |
Pharmacology of opioid inhibition to noxious uterine cervical distension.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Cervix Uteri; Dose-Response Relationship, Drug; Electromyography; Female; Hemodynamics; Morphine; Naltrexone; Narcotic Antagonists; Ovariectomy; Pain Threshold; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Uterus | 2002 |
Kappa opioid antagonist effects of the novel kappa antagonist 5'-guanidinonaltrindole (GNTI) in an assay of schedule-controlled behavior in rhesus monkeys.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Non-Narcotic; Animals; Benzamides; Benzeneacetamides; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Interactions; Female; Guanidines; Macaca mulatta; Male; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Piperazines; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Reinforcement Schedule; Time Factors | 2002 |
Opioid receptor subtypes differentially modulate serotonin efflux in the rat central nervous system.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Central Nervous System; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Male; Microdialysis; Microinjections; Naltrexone; Nucleus Accumbens; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Serotonin | 2002 |
U50,488 inhibits HIV-1 Tat-induced monocyte chemoattractant protein-1 (CCL2) production by human astrocytes.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Astrocytes; Cells, Cultured; Chemokine CCL2; Drug Interactions; Gene Products, tat; HIV-1; Humans; Naltrexone; Narcotic Antagonists; NF-kappa B; tat Gene Products, Human Immunodeficiency Virus | 2003 |
Intraventricular insulin decreases kappa opioid-mediated sucrose intake in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Feeding Behavior; Injections, Intraventricular; Insulin; Male; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Receptors, Opioid, kappa; Sucrose | 2002 |
Inhibition of urinary bladder motility by a spinal action of U-50488H in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Area Under Curve; Dose-Response Relationship, Drug; Electric Stimulation; Injections, Intravenous; Injections, Spinal; Male; Methysergide; Muscle Contraction; Muscle, Smooth; Naltrexone; Pons; Rats; Rats, Wistar; Receptors, Opioid, kappa; Reserpine; Serotonin Antagonists; Stress, Mechanical; Urinary Bladder; Urination; Yohimbine | 2002 |
Blockade of mu-opioid receptor-mediated G-protein activation and antinociception by TRK-820 in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; GTP-Binding Proteins; In Vitro Techniques; Injections, Intraventricular; Medulla Oblongata; Mice; Morphinans; Naltrexone; Narcotic Antagonists; Pain Measurement; Pons; Radioligand Assay; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spiro Compounds | 2003 |
Activation of kappa-opioid receptors inhibits pruritus evoked by subcutaneous or intrathecal administration of morphine in monkeys.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Disease Models, Animal; Drug Interactions; Female; Injections, Spinal; Injections, Subcutaneous; Macaca mulatta; Male; Morphine; Naltrexone; Narcotic Antagonists; Pruritus; Receptors, Opioid, kappa | 2003 |
Activation of the kappa-opioid receptor in Caco-2 cells decreases interleukin-8 secretion.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adjuvants, Immunologic; Caco-2 Cells; Dose-Response Relationship, Drug; Humans; Immunohistochemistry; Interleukin-1; Interleukin-8; Naltrexone; Receptors, Opioid, kappa; Reverse Transcriptase Polymerase Chain Reaction | 2003 |
Buprenorphine blocks epsilon- and micro-opioid receptor-mediated antinociception in the mouse.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; beta-Endorphin; Buprenorphine; Disease Models, Animal; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Time Factors | 2003 |
Effects of in vitro and in vivo opioids on the production of IL-12 and IL-10 by murine macrophages.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enzyme-Linked Immunosorbent Assay; Interleukin-10; Interleukin-12; Macrophages, Peritoneal; Male; Mice; Mice, Inbred BALB C; Morphine; Naltrexone; Pain | 2003 |
Effects of U50,488H on transient outward and ultra-rapid delayed rectifier K+ currents in young human atrial myocytes.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adolescent; Child; Child, Preschool; Delayed Rectifier Potassium Channels; Female; Heart Atria; Humans; Infant; Male; Myocytes, Cardiac; Naloxone; Naltrexone; Narcotic Antagonists; Patch-Clamp Techniques; Potassium Channels; Potassium Channels, Tandem Pore Domain; Potassium Channels, Voltage-Gated; Receptors, Opioid, kappa | 2003 |
Ultra-long antagonism of kappa opioid agonist-induced diuresis by intracisternal nor-binaltorphimine in monkeys.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Diuresis; Female; Injections, Intraventricular; Macaca mulatta; Male; Naltrexone; Narcotic Antagonists; Receptors, Opioid, kappa | 2003 |
kappa-Opioid withdrawal in Planaria.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adaptation, Physiological; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Hydrogen-Ion Concentration; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Osmolar Concentration; Planarians; Reaction Time; Receptors, Opioid, kappa; Substance Withdrawal Syndrome | 2003 |
Roles of KATP channels in delayed cardioprotection and intracellular Ca(2+) in the rat heart as revealed by kappa-opioid receptor stimulation with U50488H.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Calcium; Calcium Signaling; Coronary Circulation; Coronary Vessels; Dose-Response Relationship, Drug; Heart; Heart Rate; Injections, Intravenous; Ischemic Preconditioning, Myocardial; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocytes, Cardiac; Naltrexone; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Time Factors | 2003 |
Prolonged kappa opioid receptor phosphorylation mediated by G-protein receptor kinase underlies sustained analgesic tolerance.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Cell Line; Drug Tolerance; G-Protein-Coupled Receptor Kinase 3; Humans; Mice; Mice, Inbred C57BL; Mice, Knockout; Naltrexone; Phosphorylation; Protein Serine-Threonine Kinases; Receptors, Opioid, kappa | 2004 |
Nonopioid receptor-mediated effects of U-50,488H on [Ca(2+)]i and extracellular dopamine in PC12 cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; 3,4-Dihydroxyphenylacetic Acid; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Calcium; Dopamine; Dose-Response Relationship, Drug; Intracellular Fluid; Naltrexone; Narcotic Antagonists; PC12 Cells; Rats; Receptors, Opioid, kappa | 2003 |
Enhanced sensitivity to the antinociceptive effects of kappa opioids in naltrexone-treated rats: dose- and time-dependent effects.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Non-Narcotic; Animals; Dose-Response Relationship, Drug; Drug Administration Schedule; Male; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Pentazocine; Pyrrolidines; Rats; Rats, Long-Evans; Receptors, Opioid, kappa | 2003 |
Opioid-mediated modulation of calcium currents in striatal and pallidal neurons following reserpine treatment: focus on kappa response.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic Uptake Inhibitors; Alkaloids; Analgesics, Non-Narcotic; Analgesics, Opioid; Analysis of Variance; Animals; Benzophenanthridines; Calcium Channel Blockers; Calcium Channels; Cell Size; Cells, Cultured; Corpus Striatum; Dose-Response Relationship, Drug; Drug Interactions; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enzyme Inhibitors; Male; Membrane Potentials; Naltrexone; Narcotic Antagonists; Neural Inhibition; Neurons; omega-Conotoxin GVIA; Patch-Clamp Techniques; Phenanthridines; Rats; Rats, Wistar; Receptors, Opioid, kappa; Reserpine | 2004 |
Region-dependent G-protein activation by kappa-opioid receptor agonists in the mouse brain.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzeneacetamides; Brain; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice; Morphinans; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid, kappa; Spiro Compounds | 2004 |
Effects of the kappa opioid agonist U50,488 and the kappa opioid antagonist nor-binaltorphimine on choice between cocaine and food in rhesus monkeys.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Behavior, Addictive; Choice Behavior; Cocaine; Dose-Response Relationship, Drug; Eating; Macaca mulatta; Male; Naltrexone; Receptors, Opioid, kappa | 2004 |
Mu opioid modulation of oxytocin secretion in late pregnant and parturient rats. Involvement of noradrenergic neurotransmission.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Cinnamates; Enzyme-Linked Immunosorbent Assay; Estrogens; Female; Methoxyhydroxyphenylglycol; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Narcotics; Norepinephrine; Oxytocin; Paraventricular Hypothalamic Nucleus; Pregnancy; Progesterone; Rats; Rats, Wistar; Receptors, Opioid, kappa; Receptors, Opioid, mu; Supraoptic Nucleus | 2004 |
Sexual dimorphism in the antinociception mediated by kappa opioid receptors in the rat temporomandibular joint.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Dose-Response Relationship, Drug; Estrous Cycle; Female; Formaldehyde; Male; Naltrexone; Pain Measurement; Rats; Rats, Wistar; Receptors, Opioid, kappa; Sex Characteristics; Temporomandibular Joint | 2004 |
A Tyr-W-MIF-1 analog containing D-Pro2 acts as a selective mu2-opioid receptor antagonist in the mouse.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Male; Mice; MSH Release-Inhibiting Hormone; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Receptors, Opioid, mu | 2005 |
Involvement of mu-, delta- and kappa-opioid receptor subtypes in the discriminative-stimulus effects of delta-9-tetrahydrocannabinol (THC) in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Benzamides; Conditioning, Operant; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Food; Hallucinogens; Heroin; Male; Naltrexone; Narcotic Antagonists; Narcotics; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reinforcement, Psychology | 2005 |
Characterisation of opioid receptors involved in modulating circular and longitudinal muscle contraction in the rat ileum.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enteric Nervous System; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Muscle Contraction; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu | 2005 |
Kappa opioid receptor activation disrupts prepulse inhibition of the acoustic startle in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acoustic Stimulation; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Antipsychotic Agents; Apomorphine; Clozapine; Dizocilpine Maleate; Dopamine Agonists; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Excitatory Amino Acid Antagonists; Haloperidol; Inhibition, Psychological; Male; Naltrexone; Narcotic Antagonists; Rats; Receptors, Opioid, kappa; Reflex, Startle | 2005 |
The kappa-opioid receptor is involved in the stimulating effect of nicotine on adrenocortical activity but not in nicotine induced anxiety.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Anxiety; Behavior, Animal; Corticosterone; Drug Interactions; Endocrine System; Male; Maze Learning; Naltrexone; Narcotic Antagonists; Nicotine; Nicotinic Agonists; Radioimmunoassay; Rats; Rats, Wistar; Receptors, Opioid, kappa | 2005 |
Coordinated and spatial upregulation of arc in striatonigral neurons correlates with L-dopa-induced behavioral sensitization in dyskinetic rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic Agents; AIDS-Related Complex; Amphetamine; Analgesics, Non-Narcotic; Animals; Antiparkinson Agents; Behavior, Animal; Carrier Proteins; Central Nervous System Stimulants; Corpus Striatum; Disease Models, Animal; Drug Interactions; Dynorphins; Dyskinesia, Drug-Induced; Functional Laterality; Homer Scaffolding Proteins; Immunohistochemistry; In Situ Hybridization; Levodopa; Male; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Oxidopamine; Protein Precursors; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Stereotyped Behavior; Substantia Nigra; Time Factors; Tyrosine 3-Monooxygenase; Up-Regulation | 2005 |
Vagotonic effects of enkephalin are not mediated by sympatholytic mechanisms.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Dogs; Enkephalin, Methionine; Female; Heart Rate; Male; Naltrexone; Receptors, Opioid, kappa; Sympatholytics; Vagus Nerve | 2006 |
Downstream regulatory element antagonistic modulator regulates islet prodynorphin expression.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Calcium; Cell Line; Cell Nucleus; DNA; Dynorphins; Electrophoretic Mobility Shift Assay; Enkephalins; Gene Expression Regulation; Glucagon; Glucagon-Secreting Cells; Glucose; Humans; Insulin-Secreting Cells; Islets of Langerhans; Kv Channel-Interacting Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Naltrexone; Protein Binding; Protein Precursors; Receptors, Opioid, kappa; Repressor Proteins | 2006 |
Reduction of lipopolysaccharide-induced interleukin-6 production by the kappa opioid U50,488 in a mouse monocyte-like cell line.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cell Line, Tumor; Cell Survival; Dactinomycin; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Gene Expression; Interleukin-6; Lipopolysaccharides; Mice; Monocytes; Naltrexone; Narcotic Antagonists; Oligopeptides; Receptors, Opioid, kappa; RNA Stability; Time Factors; Transcription, Genetic; Tumor Necrosis Factor-alpha | 2006 |
Kappa opioid receptor activation of p38 MAPK is GRK3- and arrestin-dependent in neurons and astrocytes.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Arrestins; Astrocytes; beta-Adrenergic Receptor Kinases; Cells, Cultured; Corpus Striatum; G-Protein-Coupled Receptor Kinase 3; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Naltrexone; Narcotic Antagonists; Neurons; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Rats; Receptors, Opioid, kappa; Signal Transduction | 2006 |
Modulation of systemic and renal haemodynamics by kappa-opioids in conscious lambs.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Aging; Analgesics, Non-Narcotic; Animals; Blood Circulation; Blood Pressure; Dynorphins; Guanidines; Heart Rate; Hemodynamics; Kidney; Naltrexone; Receptors, Opioid, kappa; Regional Blood Flow; Sheep | 2006 |
Schild (apparent pA2) analysis of a kappa-opioid antagonist in Planaria.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Algorithms; Analgesics, Non-Narcotic; Animals; Dose-Response Relationship, Drug; Locomotion; Naltrexone; Narcotic Antagonists; Planarians; Receptors, Opioid, kappa; Regression Analysis | 2006 |
Kappa-opioid receptor modulation of accumbal dopamine concentration during operant ethanol self-administration.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Area Under Curve; Behavior, Animal; Central Nervous System Depressants; Conditioning, Operant; Dopamine; Dose-Response Relationship, Drug; Drinking Behavior; Drug Interactions; Ethanol; Male; Microdialysis; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Rats; Rats, Long-Evans; Receptors, Opioid, kappa; Self Administration | 2006 |
Chronic prevention of mu-opioid receptor (MOR) G-protein coupling in the pontine parabrachial nucleus persistently decreases consumption of standard but not palatable food.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Behavior, Animal; Circadian Rhythm; Eating; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Feeding Behavior; Food Preferences; GTP-Binding Proteins; Male; Naltrexone; Narcotic Antagonists; Pons; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Opioid, mu; Time Factors | 2006 |
Anticonvulsive effects of kappa-opioid receptor modulation in an animal model of ethanol withdrawal.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Alcohol-Induced Disorders, Nervous System; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Anticonvulsants; Brain; Central Nervous System Depressants; Disease Models, Animal; Drug Interactions; Drug Synergism; Ethanol; Male; Naltrexone; Receptors, Opioid, kappa; Seizures; Species Specificity; Substance Withdrawal Syndrome; Treatment Outcome | 2006 |
Expression and localization of delta-, kappa-, and mu-opioid receptors in human spermatozoa and implications for sperm motility.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adult; Analgesics, Opioid; Humans; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sperm Motility; Spermatozoa; Tissue Distribution | 2006 |
Thienorphine: receptor binding and behavioral effects in rhesus monkeys.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Binding, Competitive; Buprenorphine; Cells, Cultured; Discrimination, Psychological; Dose-Response Relationship, Drug; Female; Hot Temperature; Ligands; Macaca mulatta; Male; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Reinforcement Schedule | 2007 |
Sciatic nerve ligation-induced proliferation of spinal cord astrocytes is mediated by kappa opioid activation of p38 mitogen-activated protein kinase.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Astrocytes; Cell Proliferation; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Glial Fibrillary Acidic Protein; Hyperalgesia; Hyperesthesia; Imidazoles; In Vitro Techniques; Ligation; Lumbar Vertebrae; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Naltrexone; Narcotic Antagonists; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Receptors, Opioid, kappa; Sciatic Nerve; Spinal Cord | 2007 |
Endogenous dynorphin in epileptogenesis and epilepsy: anticonvulsant net effect via kappa opioid receptors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzamides; Cell Count; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Epilepsy, Temporal Lobe; Guanidines; Hippocampus; Kindling, Neurologic; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphinans; Naltrexone; Nerve Degeneration; Piperazines; Protein Precursors; Receptors, Opioid, kappa; Synaptic Transmission; Time Factors | 2007 |
Transient activation of the CA3 Kappa opioid system in the dorsal hippocampus modulates complex memory processing in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analysis of Variance; Animals; Avoidance Learning; Conditioning, Classical; Dose-Response Relationship, Drug; Fear; Hippocampus; Male; Maze Learning; Memory; Mice; Mice, Inbred C57BL; Microinjections; Naltrexone; Receptors, Opioid, kappa; Spatial Behavior | 2007 |
Antagonism of phosphoramidon-induced antinociception in mice by mu- but not kappa-opioid receptor blockers.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Glycopeptides; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2007 |
Selectivity of delta- and kappa-opioid ligands depends on the route of central administration in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzylidene Compounds; Enkephalin, D-Penicillamine (2,5)-; Injections, Intraventricular; Injections, Spinal; Ligands; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Receptors, Opioid, kappa | 2007 |
Renal responses to the kappa-opioid-receptor agonist U-50488H in conscious lambs.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Aging; Analgesics, Non-Narcotic; Animals; Animals, Newborn; Diuresis; Dose-Response Relationship, Drug; Electrolytes; Guanidines; Kidney; Naltrexone; Receptors, Opioid, kappa; Sheep; Urodynamics | 2007 |
[Role of kappa-opioid receptors in the regulation of cardiac resistance to arrhythmogenic effects of ischemia and reperfusion].
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Myocardial Reperfusion Injury; Myocardium; Naloxone; Naltrexone; Piperazines; Pyrrolidines; Quaternary Ammonium Compounds; Rats; Rats, Wistar; Receptors, Opioid, kappa | 2006 |
Relative contribution of peripheral versus central opioid receptors to antinociception.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetic Acid; Analgesics, Non-Narcotic; Analgesics, Opioid; Analysis of Variance; Animals; Calcitonin Gene-Related Peptide; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Interactions; Gene Expression; Loperamide; Male; Mice; Mice, Inbred C57BL; Naltrexone; Narcotic Antagonists; Pain; Receptors, Opioid | 2007 |
Ethanol alters the effect of kappa receptor ligands on dopamine release in the nucleus accumbens.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Central Nervous System Stimulants; Dopamine; Drug Administration Schedule; Drug Interactions; Drug Tolerance; Dynorphins; Ethanol; Male; Naltrexone; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa | 2007 |
Involvement of kappa opioid receptors in formalin-induced inhibition of analgesic tolerance to morphine in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Chronic Disease; Drug Tolerance; Formaldehyde; Male; Mice; Morphine; Naltrexone; Oligonucleotides, Antisense; Pain; Pain Measurement; Pain Threshold; Receptors, Opioid, delta; Receptors, Opioid, kappa; Tail | 2007 |
Activation of kappa-opioid receptor as a method for prevention of ischemic and reperfusion arrhythmias: role of protein kinase C and K(ATP) channels.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Alkaloids; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzophenanthridines; Glyburide; Male; Myocardial Reperfusion Injury; Naltrexone; Oxymorphone; Potassium Channels; Protein Kinase C; Rats; Rats, Wistar; Receptors, Opioid, kappa | 2007 |
The dysphoric component of stress is encoded by activation of the dynorphin kappa-opioid system.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Conditioning, Operant; Corticotropin-Releasing Hormone; Dose-Response Relationship, Drug; Drug Interactions; Dynorphins; Enkephalins; Mice; Mice, Inbred C57BL; Mice, Knockout; Naltrexone; Narcotic Antagonists; Odorants; Phosphorylation; Protein Precursors; Receptors, Opioid, kappa; Stress, Physiological; Swimming; Urocortins | 2008 |
The comparison of effects of processed Aconiti tuber, U50488H and MK-801 on the antinociceptive tolerance to morphine.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Aconitum; Analgesics, Opioid; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Tolerance; Male; Mice; Morphine; Naltrexone; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa | 2008 |
Activation of kappa opioid receptors decreases synaptic transmission and inhibits long-term potentiation in the basolateral amygdala of the mouse.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amygdala; Analgesics, Non-Narcotic; Animals; Chronic Disease; Electric Stimulation; Electrophysiology; Emotions; Extinction, Psychological; Long-Term Potentiation; Male; Mice; Mice, Inbred C57BL; Naltrexone; Pain; Receptors, Opioid, kappa; Synaptic Transmission | 2009 |
Crucial role of peripheral kappa-opioid receptors in a model of periodontal disease in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Chronic Periodontitis; Disease Models, Animal; Male; Morphine; Naltrexone; Narcotic Antagonists; Peripheral Nervous System; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa | 2008 |
kappa-Opioid receptor stimulation inhibits augmentation of Ca(2+) transient and hypertrophy induced by isoprenaline in neonatal rat ventricular myocytes - Role of CaMKIIdelta(B).
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Animals, Newborn; Benzylamines; Calcium Channel Blockers; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Nucleus; Cell Size; Cells, Cultured; Hypertrophy; Isoproterenol; Myocytes, Cardiac; Naltrexone; Narcotic Antagonists; Propranolol; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta-1; Receptors, Opioid, kappa; Sulfonamides; Verapamil | 2008 |
Prodynorphin-derived peptides are critical modulators of anxiety and regulate neurochemistry and corticosterone.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amygdala; Animals; Anxiety; Brain Stem; Corticosterone; Corticotropin-Releasing Hormone; Dynorphins; Enkephalins; Exploratory Behavior; Female; Guanidines; Hypothalamus; Male; Maze Learning; Mesencephalon; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphinans; Naltrexone; Neuropeptide Y; Neuropeptides; Protein Precursors; Raphe Nuclei; Receptors, Opioid, kappa; Stress, Psychological | 2009 |
Nociceptin produces antinociception after spinal administration in amphibians.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetic Acid; Analgesics; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, D-Penicillamine (2,5)-; Fentanyl; Injections, Spinal; Naltrexone; Nociceptin; Opioid Peptides; Pain Threshold; Peptide Fragments; Rana pipiens | 2009 |
Kappa-opioid system regulates the long-lasting behavioral adaptations induced by early-life exposure to methylphenidate.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Anxiety; Behavior, Animal; Central Nervous System Stimulants; Cocaine; Conditioning, Psychological; Food Preferences; Male; Methylphenidate; Motor Activity; Naltrexone; Psychotropic Drugs; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Stress, Psychological | 2009 |
Endogenous kappa opioid activation mediates stress-induced deficits in learning and memory.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Behavior, Animal; Enkephalins; Gene Expression Regulation; Immobility Response, Tonic; Learning Disabilities; Male; Memory Disorders; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Naltrexone; Narcotic Antagonists; Protein Precursors; Receptors, Opioid, kappa; Recognition, Psychology; Stress, Psychological; Swimming; Time Factors | 2009 |
Route of administration influences substitution patterns in rats trained to discriminate methadone vs. vehicle.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Choice Behavior; Conditioning, Operant; Discrimination, Psychological; Heroin; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Methadone; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Pharmaceutical Vehicles; Rats; Rats, Sprague-Dawley; Stereoisomerism | 2009 |
The individual and combined effects of U50,488, and flurbiprofen axetil on visceral pain in conscious rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Abdominal Muscles; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Catheterization; Dose-Response Relationship, Drug; Drug Synergism; Flurbiprofen; Male; Muscle Contraction; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Rectum | 2009 |
Prodynorphin gene deficiency potentiates nalbuphine-induced behavioral sensitization and withdrawal syndrome in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Area Under Curve; Blotting, Western; Dopamine; Enkephalins; Gene Expression; Genes, fos; Mice; Mice, Knockout; Microdialysis; Motor Activity; Nalbuphine; Naloxone; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Protein Precursors; Receptors, Opioid, kappa; Reverse Transcriptase Polymerase Chain Reaction; Substance Withdrawal Syndrome | 2009 |
Myocardial apoptosis and infarction after ischemia/reperfusion are attenuated by kappa-opioid receptor agonist.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Antihypertensive Agents; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Caspase 9; DNA Fragmentation; Male; Microscopy, Electron, Transmission; Myocardial Infarction; Myocardium; Naltrexone; Narcotic Antagonists; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reperfusion Injury | 2009 |
Activation of the kappa opioid receptor in the dorsal raphe nucleus mediates the aversive effects of stress and reinstates drug seeking.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analysis of Variance; Animals; Cocaine; Enzyme-Linked Immunosorbent Assay; Immunohistochemistry; Lentivirus; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Naltrexone; Raphe Nuclei; Receptors, Opioid, kappa; Stress, Physiological; Ventral Tegmental Area | 2009 |
Involvement of the kappa-opioid receptor in nitrous oxide-induced analgesia in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics, Non-Narcotic; Animals; Benzamides; Male; Mice; Mice, Inbred C57BL; Naltrexone; Narcotic Antagonists; Nitrous Oxide; Pain; Piperazines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Treatment Outcome | 2010 |
The effects of kappa-opioid receptor ligands on prepulse inhibition and CRF-induced prepulse inhibition deficits in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzeneacetamides; Corticotropin-Releasing Hormone; Diterpenes, Clerodane; Dose-Response Relationship, Drug; Ligands; Male; Naltrexone; Neural Inhibition; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reflex, Startle | 2010 |
Pretreatment time with norbinaltorphimine.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Injections, Intraventricular; Injections, Spinal; Ischemic Preconditioning, Myocardial; Morphine; Naltrexone; Narcotic Antagonists; Rats; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2010 |
Effectiveness of analogs of the kappa opioid receptor antagonist (3R)-7-hydroxy-N-((1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JDTic) to reduce U50,488-induced diure
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cocaine-Related Disorders; Diuresis; Dose-Response Relationship, Drug; Male; Naltrexone; Pain; Piperidines; Rats; Rats, Long-Evans; Receptors, Opioid, kappa; Self Administration; Tetrahydroisoquinolines | 2010 |
Alteration of intravenous nicotine self-administration by opioid receptor agonist and antagonists in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Dose-Response Relationship, Drug; Feeding Behavior; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nicotine; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Self Administration; Tobacco Use Disorder | 2010 |
Endogenous kappa-opioid mediation of stress-induced potentiation of ethanol-conditioned place preference and self-administration.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Conditioning, Psychological; Enkephalins; Ethanol; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Naltrexone; Protein Precursors; Receptors, Opioid, kappa; Reward; Self Administration; Signal Transduction; Stress, Physiological | 2010 |
Behavioral stress may increase the rewarding valence of cocaine-associated cues through a dynorphin/kappa-opioid receptor-mediated mechanism without affecting associative learning or memory retrieval mechanisms.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analysis of Variance; Anesthetics, Local; Animals; Association Learning; Behavior, Animal; Cocaine; Conditioning, Operant; Cues; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Dynorphins; Exploratory Behavior; Male; Mental Recall; Mice; Mice, Inbred C57BL; Naltrexone; Narcotic Antagonists; Receptors, Opioid, kappa; Reward; Stress, Psychological; Swimming | 2010 |
Sex-specificity and estrogen-dependence of kappa opioid receptor-mediated antinociception and antihyperalgesia.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Area Under Curve; Dose-Response Relationship, Drug; Estradiol; Estrous Cycle; Female; Inflammation; Injections, Spinal; Lumbosacral Region; Male; Naltrexone; Orchiectomy; Ovariectomy; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reverse Transcriptase Polymerase Chain Reaction; Sex Characteristics; Spinal Cord; Testosterone | 2010 |
U50,488H postconditioning reduces apoptosis after myocardial ischemia and reperfusion.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Androstadienes; Animals; Apoptosis; Cardiotonic Agents; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Naltrexone; Narcotic Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Phosphoinositide-3 Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Wortmannin | 2011 |
[The study of effects and mechanism of U50, 488H on electrical coupling during ischemia in the perfused isolated rat heart].
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzophenanthridines; Connexin 43; Female; Heart; In Vitro Techniques; Myocardial Ischemia; Myocardium; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Signal Transduction | 2010 |
Buprenorphine and opioid antagonism, tolerance, and naltrexone-precipitated withdrawal.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Buprenorphine; Dose-Response Relationship, Drug; Drug Tolerance; Female; Levorphanol; Macaca mulatta; Male; Naltrexone; Narcotic Antagonists; Substance Withdrawal Syndrome | 2011 |
[Delayed electrical uncoupling is involved in kappa-opioid receptor activation -induced cardioprotective effect in the isolated rat heart].
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Antihypertensive Agents; Heart; In Vitro Techniques; Male; Myocardial Ischemia; Myocardium; Naltrexone; Potassium Channels; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa | 2006 |
Local kappa opioid receptor activation decreases temporomandibular joint inflammation.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Movement; Dose-Response Relationship, Drug; Formaldehyde; Inflammation; Male; Naltrexone; Neutrophil Infiltration; Neutrophils; Rats; Rats, Wistar; Receptors, Opioid, kappa; Temporomandibular Joint | 2012 |
Drug discrimination in pigeons trained to discriminate among morphine, U50488, a combination of these drugs, and saline.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Butorphanol; Columbidae; Discrimination Learning; Dose-Response Relationship, Drug; Ethylketocyclazocine; Male; Morphine; Naltrexone; Narcotic Antagonists; Pentazocine; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reinforcement Schedule; Sodium Chloride | 2011 |
Sex difference in κ-opioid receptor (KOPR)-mediated behaviors, brain region KOPR level and KOPR-mediated guanosine 5'-O-(3-[35S]thiotriphosphate) binding in the guinea pig.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Non-Narcotic; Animals; Brain; Cocaine; Dopamine Uptake Inhibitors; Female; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Male; Mice; Motor Activity; Movement; Naltrexone; Narcotic Antagonists; Posture; Rats; Receptors, Opioid, kappa; Sex Characteristics | 2011 |
Opioidergic modulation of ethanol self-administration in the ventral pallidum.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Alcohol Drinking; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Globus Pallidus; Male; Microinjections; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Self Administration; Somatostatin | 2012 |
[Model of platelet activation as experimental test system for screening kappa-opioid receptor ligands].
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Benzimidazoles; Blood Platelets; Butorphanol; High-Throughput Screening Assays; Ligands; Light; Naltrexone; Platelet Activation; Rabbits; Receptors, Opioid, kappa; Scattering, Radiation | 2011 |
Effect of κ-opioid receptor agonist on the growth of non-small cell lung cancer (NSCLC) cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Resistance, Neoplasm; ErbB Receptors; Gefitinib; Gene Expression; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Mutation, Missense; Naltrexone; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinazolines; Receptors, Opioid, kappa; Signal Transduction; STAT3 Transcription Factor | 2012 |
κ opioid regulation of anxiety-like behavior during acute ethanol withdrawal.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Alcoholism; Animals; Anxiety; Behavior, Animal; Ethanol; Male; Naltrexone; Rats; Rats, Wistar; Receptors, Opioid, kappa; Substance Withdrawal Syndrome | 2012 |
Dysregulation of kappa-opioid receptor systems by chronic nicotine modulate the nicotine withdrawal syndrome in an age-dependent manner.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Aging; Animals; Behavior, Animal; Dopamine; Dose-Response Relationship, Drug; Male; Naltrexone; Nicotine; Nucleus Accumbens; Rats; Rats, Wistar; Receptors, Opioid, kappa; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2012 |
The effects of κ-opioid receptor on stretch-induced electrophysiological changes in infarcted rat hearts.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Action Potentials; Animals; Arrhythmias, Cardiac; Electrophysiological Phenomena; Male; Myocardial Infarction; Naltrexone; Pressoreceptors; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa | 2013 |
GPR54-dependent stimulation of luteinizing hormone secretion by neurokinin B in prepubertal rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Antihypertensive Agents; Bodily Secretions; Female; Kisspeptins; Luteinizing Hormone; Male; Naltrexone; Narcotic Antagonists; Neurokinin B; Peptide Fragments; Radioimmunoassay; Rats; Receptors, G-Protein-Coupled; Receptors, Kisspeptin-1; Receptors, Tachykinin; Substance P | 2012 |
Effects of κ- and μ-opioid agonists on cholinergic neurotransmission and contraction in isolated bovine trachealis.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetylcholine; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Atropine; Cattle; Drug Interactions; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; In Vitro Techniques; Muscarinic Agonists; Muscarinic Antagonists; Muscle Contraction; Naltrexone; Narcotic Antagonists; Pilocarpine; Receptors, Opioid, kappa; Receptors, Opioid, mu; Trachea; Tritium | 2013 |
Vasculoprotective effect of U50,488H in rats exposed to chronic hypoxia: role of Akt-stimulated NO production.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Apoptosis; Cells, Cultured; Endothelium, Vascular; Hypoxia; In Vitro Techniques; Male; Models, Animal; Naltrexone; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphorylation; Proto-Oncogene Proteins c-akt; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa | 2013 |
Dissociable effects of kappa-opioid receptor activation on impulsive phenotypes in wistar rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Conditioning, Operant; Dose-Response Relationship, Drug; Impulsive Behavior; Infusions, Intraventricular; Male; Naltrexone; Narcotic Antagonists; Phenotype; Rats; Receptors, Opioid, kappa | 2013 |
Protracted withdrawal from ethanol and enhanced responsiveness stress: regulation via the dynorphin/kappa opioid receptor system.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Alcoholism; Analgesics, Non-Narcotic; Animals; Anxiety; Dose-Response Relationship, Drug; Dynorphins; Ethanol; Male; Maze Learning; Motor Activity; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid, kappa; Stress, Psychological; Substance Withdrawal Syndrome | 2013 |
Locus coeruleus kappa-opioid receptors modulate reinstatement of cocaine place preference through a noradrenergic mechanism.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic alpha-2 Receptor Agonists; Adrenergic beta-1 Receptor Antagonists; Adrenergic beta-Antagonists; Animals; Betaxolol; Clonidine; Cocaine; Conditioning, Psychological; Drug-Seeking Behavior; Locus Coeruleus; Male; Mice; Mice, Inbred C57BL; Naltrexone; Propanolamines; Propranolol; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Receptors, Opioid, kappa | 2013 |
Dynorphins regulate the strength of social memory.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amygdala; Animals; Enkephalins; Hippocampus; Memory; Mice; Mice, Knockout; Naltrexone; Narcotic Antagonists; Protein Precursors; Receptors, Opioid, kappa; Recognition, Psychology; Social Behavior | 2014 |
Role of the kappa-opioid receptor system in stress-induced reinstatement of nicotine seeking in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic alpha-2 Receptor Antagonists; Analgesics, Non-Narcotic; Animals; Conditioning, Operant; Drug Administration Schedule; Drug Interactions; Extinction, Psychological; Male; Naltrexone; Nicotine; Nicotinic Agonists; Rats; Rats, Long-Evans; Receptors, Opioid, kappa; Self Administration; Stress, Psychological; Tobacco Use Disorder; Yohimbine | 2014 |
Effects of systemic opioid receptor ligands on ethanol- and sucrose seeking and drinking in alcohol-preferring (P) and Long Evans rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Behavior, Addictive; Behavior, Animal; Ethanol; Ligands; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Long-Evans; Receptors, Opioid; Sucrose | 2014 |
Anti-nociception mediated by a κ opioid receptor agonist is blocked by a δ receptor agonist.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Behavior, Animal; Benzamides; Diazepam; Etorphine; Female; Hot Temperature; Male; Mice, Inbred C57BL; Mice, Knockout; Naltrexone; Nociceptin Receptor; Nociception; Piperazines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stress, Psychological | 2015 |
The role of kappa opioid receptors in stress-induced reinstatement of alcohol seeking in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Behavior, Addictive; Behavior, Animal; Cues; Drug-Seeking Behavior; Ethanol; Male; Naltrexone; Narcotic Antagonists; Pyrimidines; Pyrroles; Rats; Rats, Long-Evans; Receptors, Corticotropin-Releasing Hormone; Receptors, Opioid, kappa; Self Administration; Stress, Physiological; Yohimbine | 2014 |
Activation of κ-opioid receptor exerts the glucose-homeostatic effect in streptozotocin-induced diabetic mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adiponectin; AMP-Activated Protein Kinases; Analgesics, Non-Narcotic; Animals; Blood Glucose; Blotting, Western; Diabetes Mellitus, Experimental; Gene Expression; Glucose Transporter Type 4; Homeostasis; Hyperglycemia; Insulin; Male; Mice, Inbred BALB C; Naltrexone; Narcotic Antagonists; Phosphorylation; Protein Transport; Receptors, Adiponectin; Receptors, Opioid, kappa; Reverse Transcriptase Polymerase Chain Reaction | 2015 |
[κ-opioid receptor agonist U50, 488H attenuates myocardial ischemia-reperfusionvia modulating Toll-like receptor 4/nuclear factor-κB signaling in rat].
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Arrhythmias, Cardiac; Brugada Syndrome; Cardiac Conduction System Disease; Coronary Artery Disease; Down-Regulation; Heart Conduction System; Myocardial Infarction; Myocardial Ischemia; Myocardium; Naltrexone; NF-kappa B; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reperfusion Injury; Signal Transduction; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha | 2014 |
Investigation of the role of βarrestin2 in kappa opioid receptor modulation in a mouse model of pruritus.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Arrestins; beta-Arrestins; Chloroquine; Disease Models, Animal; Dose-Response Relationship, Drug; Guanidines; Isoquinolines; Male; Mice, Inbred C57BL; Mice, Knockout; Morphinans; Motor Activity; Naltrexone; Pruritus; Receptors, Opioid, kappa | 2015 |
κ-Opioid Receptor Stimulation Improves Endothelial Function via Akt-stimulated NO Production in Hyperlipidemic Rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Aorta; Blood Glucose; Diet, High-Fat; Endothelial Cells; Human Umbilical Vein Endothelial Cells; Humans; Hyperlipidemias; Liver; Male; Naltrexone; Nitric Oxide; Nitric Oxide Synthase; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Signal Transduction | 2016 |
Effects of the psychotomimetic benzomorphan N-allylnormetazocine (SKF 10,047) on prepulse inhibition of startle in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Anisoles; Dose-Response Relationship, Drug; Hallucinogens; Male; Mice; Mice, Inbred C57BL; Naltrexone; Phenazocine; Prepulse Inhibition; Propylamines; Receptors, Opioid, kappa; Receptors, Phencyclidine; Receptors, sigma; Reflex, Startle; Sigma-1 Receptor; Stereoisomerism | 2016 |
Methyl-orvinol-Dual activity opioid receptor ligand inhibits gastrointestinal transit and alleviates abdominal pain in the mouse models mimicking diarrhea-predominant irritable bowel syndrome.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Abdominal Pain; Analgesics; Analgesics, Opioid; Animals; Colon; Diarrhea; Disease Models, Animal; Gastrointestinal Motility; Gastrointestinal Transit; Irritable Bowel Syndrome; Male; Mice; Mice, Inbred BALB C; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Receptors, Opioid; Thebaine | 2017 |
The effects of kratom on restraint-stress-induced analgesia and its mechanisms of action.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Male; Mice; Mice, Transgenic; Mitragyna; Naltrexone; Plant Extracts; Plant Leaves; Receptors, Opioid, mu; Restraint, Physical; Stress, Physiological | 2017 |
Effects of pharmacological manipulation of the kappa opioid receptors on the aversive effects of nicotine.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Avoidance Learning; Conditioning, Operant; Male; Naltrexone; Narcotic Antagonists; Nicotine; Rats; Rats, Wistar; Receptors, Opioid, kappa; Taste | 2018 |
The Protective Effects of Κ-Opioid Receptor Stimulation in Hypoxic Pulmonary Hypertension Involve Inhibition of Autophagy Through the AMPK-MTOR Pathway.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; AMP-Activated Protein Kinases; Animals; Antihypertensive Agents; Apoptosis; Autophagy; Blood Pressure; Cell Proliferation; Cells, Cultured; Chloroquine; Disease Models, Animal; Hypertension, Pulmonary; Male; Myocytes, Smooth Muscle; Naltrexone; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Signal Transduction; TOR Serine-Threonine Kinases | 2017 |
κ-opioid receptor activation protects against myocardial ischemia-reperfusion injury via AMPK/Akt/eNOS signaling activation.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cell Line; Cell Survival; Male; Myocardial Reperfusion Injury; Myocytes, Cardiac; Naltrexone; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Proto-Oncogene Proteins c-akt; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Ribonucleotides; Signal Transduction; Troponin T | 2018 |
Naltrexone and nalmefene attenuate cocaine place preference in male mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics, Opioid; Animals; Cocaine; Conditioning, Psychological; Dose-Response Relationship, Drug; Locomotion; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists | 2018 |
Dynorphin-kappa opioid receptor activity in the central amygdala modulates binge-like alcohol drinking in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Behavior, Animal; Binge Drinking; Central Amygdaloid Nucleus; Disease Models, Animal; Dynorphins; Genetic Techniques; Male; Mice; Mice, Inbred C57BL; Naltrexone; Receptors, Opioid, kappa | 2019 |
κ-Opioid receptor stimulation reduces palmitate-induced apoptosis via Akt/eNOS signaling pathway.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Survival; Gene Expression Regulation; Human Umbilical Vein Endothelial Cells; Humans; Naltrexone; Narcotic Antagonists; Nitric Oxide Synthase Type III; Palmitic Acid; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Receptors, Opioid, kappa; RNA, Small Interfering; Signal Transduction | 2019 |
Suppression of Human Natural Killer Cells by Different Classes of Opioids.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Anesthesia; Buprenorphine; Enkephalin, D-Penicillamine (2,5)-; Fentanyl; Fluoresceins; Humans; Immunosuppression Therapy; K562 Cells; Killer Cells, Natural; Loperamide; Methadone; Morphinans; Morphine; Naloxone; Naltrexone; Succinimides; Toll-Like Receptor 4; Tramadol | 2019 |
κ-opioid receptor activation promotes mitochondrial fusion and enhances myocardial resistance to ischemia and reperfusion injury via STAT3-OPA1 pathway.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Apoptosis; Cells, Cultured; GTP Phosphohydrolases; Male; Mice, Inbred C57BL; Mitochondrial Dynamics; Myocardial Reperfusion Injury; Myocardium; Naltrexone; Narcotic Antagonists; Phosphorylation; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Signal Transduction; STAT3 Transcription Factor | 2020 |
Delta and kappa opioid receptors on mouse sperm cells: Expression, localization and involvement on in vitro fertilization.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Blastocyst; Embryo, Mammalian; Embryonic Development; Enkephalin, D-Penicillamine (2,5)-; Fertilization in Vitro; Male; Mice; Naltrexone; Narcotic Antagonists; Oocytes; Receptors, Opioid, delta; Receptors, Opioid, kappa; Sperm Capacitation; Spermatozoa | 2020 |
Kappa opioid receptor controls neural stem cell differentiation via a miR-7a/Pax6 dependent pathway.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Basic Helix-Loop-Helix Transcription Factors; Cell Differentiation; Dynorphins; Gene Expression Regulation, Developmental; Hippocampus; Humans; Mice; MicroRNAs; Naltrexone; Nerve Tissue Proteins; Neural Stem Cells; Neurogenesis; PAX6 Transcription Factor; Receptors, Opioid, kappa; Signal Transduction | 2021 |
Antidepressant-like effects of dezocine in mice: involvement of 5-HT1A and κ opioid receptors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Antidepressive Agents; Behavior, Animal; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Drug Monitoring; Drug Therapy, Combination; Mice; Naltrexone; Piperazines; Pyridines; Receptors, Opioid, kappa; Receptors, Opioid, mu; Serotonin 5-HT1 Receptor Antagonists; Tetrahydronaphthalenes; Treatment Outcome | 2021 |