naltrexone and saccharin

naltrexone has been researched along with saccharin in 38 studies

Research

Studies (38)

TimeframeStudies, this research(%)All Research%
pre-19905 (13.16)18.7374
1990's8 (21.05)18.2507
2000's10 (26.32)29.6817
2010's11 (28.95)24.3611
2020's4 (10.53)2.80

Authors

AuthorsStudies
Andricopulo, AD; Moda, TL; Montanari, CA1
Geter, B; Kautz, MA; Riley, AL; Smurthwaite, ST1
Calcagnetti, DJ; Calcagnetti, RL; Fanselow, MS1
Liebeskind, JC; Lieblich, I; Yirmiya, R1
Lieblich, I; Yirmiya, R1
Bechara, A; Martin, GM; van der Kooy, D1
DeVito, MJ; Wagner, GC1
Cooper, SJ1
Froehlich, JC; Jing, SL; Krishnan-Sarin, S; Kurtz, DL; Li, TK; Portoghese, PS; Zweifel, M1
Keshet, GI; Weinstock, M1
Beczkowska, IW; Bodnar, RJ; Bostock, ME; Koch, JE; Leibowitz, SF1
Biggs, TA; Myers, RD1
Chow, BL; Sellers, EM; Tomkins, DM1
Campbell, UC; Carroll, ME; Cosgrove, KP; Rodefer, JS1
McNally, GP; Westbrook, RF1
Bandy, AL; Lee, AM; Middaugh, LD1
Calderon, SN; Hutchinson, AC; Randall, JF; Rice, KC; Riley, AL; Simpson, GR; Zhang, X1
Amit, Z; Babinska, I; Campisi, M; Goodwin, FL1
Frisina, PG; Sclafani, A1
Cummings, R; Eiler, WJ; Foster, KL; Garcia, M; Grey, C; Hawkins, SE; June, HL; Mason, D; McCane, S; McKay, PF; Seyoum, R1
Bespalov, A; Danysz, W; Kashkin, V; Malyshkin, A; Neznanova, O; Sukhotina, I; Zakharova, E1
Bakalkin, G; Kreek, MJ; Kuzmin, A; Liljequist, S1
Gilpin, NW; Ji, D; Koob, GF; Richardson, HN; Rivier, CL1
Anker, JJ; Avant, RA; Carroll, ME; Gosnell, BA; Levine, AS; Mitra, A1
Brown, ML; Kellar, KJ; Levin, ED; Li, TK; Lumeng, L; McDowell, BE; Paige, MA; Petro, A; Rezvani, AH; Rose, JE; Slade, S; Wells, C; Xiao, Y1
Acquas, E; Fois, GR; Muggironi, G; Peana, AT; Vinci, S; Zinellu, M1
Nizhnikov, ME; Pautassi, RM; Rahmani, P; Spear, NE; Varlinskaya, EI1
Badalia, A; Bodnar, RJ; Duenas, SM; Hossain, M; Rotella, FM; Saeed, S; Sclafani, A; Touzani, K1
Banakos, T; Bernal, SY; Bodnar, RJ; Malkusz, DC; Malkusz, G; Mohamed, A; Vongwattanakit, T1
Inui, T; Shimura, T1
Augier, E; Dulman, RS; Flanigan, M; Heilig, M; Kejun, C; Pincus, A; Rice, KC; Schank, JR; Tapocik, JD1
Bodnar, RJ; Huang, D; Kraft, TT; La Magna, S; Lolier, M; Natanova, E; Sclafani, A; Warshaw, D; Yakubov, Y1
Anderson, SM; Brunzell, DH; Shelton, KL; Stafford, AM1
Kreek, MJ; Zhou, Y1
Font, L; Morales, I; Pastor, R; Rodríguez-Borillo, O1
Alazzani, M; Alhusban, AY; Alzoubi, KH; Bawaane, A; Khabour, OF; Nuseir, KQ1
Fletcher, PJ; Lê, AD; Li, Z; Tabbara, RI1
Berglas, E; Bodnar, RJ; Carata, I; Castillo, A; Nashed, M; Pines, R; Roland, M; Sclafani, A1

Other Studies

38 other study(ies) available for naltrexone and saccharin

ArticleYear
Hologram QSAR model for the prediction of human oral bioavailability.
    Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24

    Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2007
Naloxone as a stimulus in drug discrimination learning: generalization to other opiate antagonists.
    Pharmacology, biochemistry, and behavior, 1992, Volume: 41, Issue:1

    Topics: Animals; Cues; Diprenorphine; Discrimination Learning; Female; Generalization, Psychological; Nalorphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Saccharin

1992
Centrally administered opioid antagonists, nor-binaltorphimine, 16-methyl cyprenorphine and MR2266, suppress intake of a sweet solution.
    Pharmacology, biochemistry, and behavior, 1990, Volume: 35, Issue:1

    Topics: Animals; Benzomorphans; Drinking Behavior; Female; Glucose; Injections, Intraventricular; Morphinans; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Saccharin

1990
Reduced saccharin preference in CXBK (opioid receptor-deficient) mice.
    Brain research, 1988, Jan-12, Volume: 438, Issue:1-2

    Topics: Animals; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Naltrexone; Receptors, Opioid; Saccharin; Taste; Taste Threshold

1988
Naltrexone reverses a long term depressive effect of a toxic lithium injection on saccharin preference.
    Physiology & behavior, 1987, Volume: 39, Issue:4

    Topics: Animals; Chlorides; Female; Lithium; Lithium Chloride; Morphine; Naltrexone; Rats; Rats, Inbred Strains; Saccharin; Taste

1987
Morphine preexposure attenuates the aversive properties of opiates without preexposure to the aversive properties.
    Pharmacology, biochemistry, and behavior, 1988, Volume: 30, Issue:3

    Topics: Animals; Conditioning, Psychological; Male; Morphine; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Reference Values; Saccharin; Taste

1988
Pargyline and naltrexone fail to antagonize the gustatory avoidance response induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
    Drug and alcohol dependence, 1986, Volume: 18, Issue:3

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Avoidance Learning; Food Preferences; Male; Naltrexone; Pargyline; Pyridines; Rats; Rats, Inbred Strains; Saccharin; Taste

1986
Effects of opiate agonists and antagonists on fluid intake and saccharin choice in the rat.
    Neuropharmacology, 1983, Volume: 22, Issue:3

    Topics: Animals; Choice Behavior; Drinking Behavior; Enkephalins; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Saccharin

1983
The delta opioid receptor antagonist naltrindole attenuates both alcohol and saccharin intake in rats selectively bred for alcohol preference.
    Psychopharmacology, 1995, Volume: 120, Issue:2

    Topics: Alcohol Drinking; Animals; Drinking; Eating; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid, delta; Saccharin

1995
Maternal naltrexone prevents morphological and behavioral alterations induced in rats by prenatal stress.
    Pharmacology, biochemistry, and behavior, 1995, Volume: 50, Issue:3

    Topics: Animals; Choice Behavior; Female; Infusion Pumps, Implantable; Male; Maze Learning; Naltrexone; Narcotic Antagonists; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Saccharin; Stress, Physiological

1995
Central opioid receptor subtype antagonists differentially reduce intake of saccharin and maltose dextrin solutions in rats.
    Brain research, 1993, Aug-06, Volume: 618, Issue:2

    Topics: Animals; Drinking Behavior; Enkephalin, Leucine-2-Alanine; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Polysaccharides; Rats; Rats, Sprague-Dawley; Saccharin

1993
Naltrexone and amperozide modify chocolate and saccharin drinking in high alcohol-preferring P rats.
    Pharmacology, biochemistry, and behavior, 1998, Volume: 60, Issue:2

    Topics: Alcohol Drinking; Animals; Body Weight; Cacao; Dose-Response Relationship, Drug; Eating; Male; Naltrexone; Narcotic Antagonists; Piperazines; Rats; Rats, Inbred Strains; Saccharin; Serotonin Antagonists; Sweetening Agents; Taste

1998
Effect of naltrexone and its derivatives, nalmefene and naltrindole, on conditioned anticipatory behaviour and saccharin intake in rats.
    Behavioural pharmacology, 1997, Volume: 8, Issue:8

    Topics: Animals; Conditioning, Operant; Cues; Dose-Response Relationship, Drug; Drinking Behavior; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Saccharin; Sweetening Agents; Taste

1997
Naltrexone pretreatment decreases the reinforcing effectiveness of ethanol and saccharin but not PCP or food under concurrent progressive-ratio schedules in rhesus monkeys.
    Psychopharmacology, 1999, Volume: 141, Issue:4

    Topics: Animals; Behavior, Animal; Drug Administration Schedule; Drug Interactions; Ethanol; Excitatory Amino Acid Antagonists; Food-Drug Interactions; Macaca mulatta; Male; Naltrexone; Narcotic Antagonists; Phencyclidine; Reinforcement, Psychology; Saccharin; Self Administration

1999
Acute exposure to saccharin reduces morphine analgesia in the the rat: evidence for involvement of N-methyl-D-aspartate and peripheral opioid receptors.
    Psychopharmacology, 2000, Volume: 149, Issue:1

    Topics: Analgesia; Analgesics, Opioid; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Quaternary Ammonium Compounds; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Saccharin; Sweetening Agents

2000
Ethanol reinforcement in nondeprived mice: effects of abstinence and naltrexone.
    Alcoholism, clinical and experimental research, 2000, Volume: 24, Issue:8

    Topics: Animals; Ethanol; Food Deprivation; Male; Mice; Mice, Inbred C57BL; Naltrexone; Reinforcement, Psychology; Reward; Saccharin; Self Administration; Solutions; Sucrose; Water Deprivation

2000
Assessment of SNC 80 and naltrindole within a conditioned taste aversion design.
    Pharmacology, biochemistry, and behavior, 2000, Volume: 66, Issue:4

    Topics: Animals; Avoidance Learning; Benzamides; Conditioning, Operant; Dose-Response Relationship, Drug; Female; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Piperazines; Rats; Rats, Long-Evans; Receptors, Opioid, delta; Saccharin; Sweetening Agents; Taste

2000
Effects of naltrexone on the intake of ethanol and flavored solutions in rats.
    Alcohol (Fayetteville, N.Y.), 2001, Volume: 25, Issue:1

    Topics: Alcohol Drinking; Animals; Beverages; Drinking; Drug Combinations; Ethanol; Male; Naltrexone; Narcotic Antagonists; Quinine; Rats; Rats, Long-Evans; Rats, Wistar; Saccharin; Solutions

2001
Naltrexone suppresses the late but not early licking response to a palatable sweet solution: opioid hedonic hypothesis reconsidered.
    Pharmacology, biochemistry, and behavior, 2002, Volume: 74, Issue:1

    Topics: Animals; Dose-Response Relationship, Drug; Feeding Behavior; Female; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Reinforcement, Psychology; Saccharin; Sucrose; Sweetening Agents; Taste; Time Factors

2002
Central opioid receptors differentially regulate the nalmefene-induced suppression of ethanol- and saccharin-reinforced behaviors in alcohol-preferring (P) rats.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2004, Volume: 29, Issue:2

    Topics: Animals; Behavior, Addictive; Brain; Central Nervous System Depressants; Conditioning, Operant; Dose-Response Relationship, Drug; Ethanol; Female; Functional Laterality; Microinjections; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Reinforcement, Psychology; Saccharin

2004
The NMDA receptor channel blocker memantine and opioid receptor antagonist naltrexone inhibit the saccharin deprivation effect in rats.
    Behavioural pharmacology, 2004, Volume: 15, Issue:4

    Topics: Acamprosate; Animals; Choice Behavior; Ethanol; Male; Memantine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Saccharin; Substance Withdrawal Syndrome; Sweetening Agents; Taurine

2004
The nociceptin/orphanin FQ receptor agonist Ro 64-6198 reduces alcohol self-administration and prevents relapse-like alcohol drinking.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2007, Volume: 32, Issue:4

    Topics: Alcohol Drinking; Alcohols; Animals; Behavior, Animal; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Interactions; Imidazoles; Male; Naltrexone; Narcotic Antagonists; Nociceptin Receptor; Rats; Rats, Wistar; Receptors, Opioid; Saccharin; Self Administration; Spiro Compounds; Sweetening Agents

2007
Effects of naltrexone, duloxetine, and a corticotropin-releasing factor type 1 receptor antagonist on binge-like alcohol drinking in rats.
    Behavioural pharmacology, 2008, Volume: 19, Issue:1

    Topics: Alcohol Deterrents; Animals; Behavior, Addictive; Conditioning, Operant; Disease Models, Animal; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; Ethanol; Male; Naltrexone; Pyrimidines; Rats; Rats, Wistar; Receptors, Corticotropin-Releasing Hormone; Saccharin; Self Administration; Sweetening Agents; Thiophenes

2008
Operant responding for sucrose by rats bred for high or low saccharin consumption.
    Physiology & behavior, 2010, Mar-30, Volume: 99, Issue:4

    Topics: Animals; Behavior, Addictive; Conditioning, Operant; Dose-Response Relationship, Drug; Food Preferences; Male; Motor Activity; Naltrexone; Narcotic Antagonists; Rats; Reinforcement Schedule; Saccharin; Self Administration; Sucrose; Sweetening Agents

2010
Effects of sazetidine-A, a selective alpha4beta2 nicotinic acetylcholine receptor desensitizing agent on alcohol and nicotine self-administration in selectively bred alcohol-preferring (P) rats.
    Psychopharmacology, 2010, Volume: 211, Issue:2

    Topics: Animals; Azetidines; Dose-Response Relationship, Drug; Drug Administration Schedule; Ethanol; Male; Naltrexone; Narcotic Antagonists; Nicotine; Nicotinic Agonists; Pyridines; Rats; Receptors, Nicotinic; Reward; Saccharin; Self Administration

2010
Effect of opioid receptor blockade on acetaldehyde self-administration and ERK phosphorylation in the rat nucleus accumbens.
    Alcohol (Fayetteville, N.Y.), 2011, Volume: 45, Issue:8

    Topics: Acetaldehyde; Animals; Enzyme Activation; Ethanol; Extracellular Signal-Regulated MAP Kinases; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Phosphorylation; Rats; Rats, Wistar; Receptors, Opioid, mu; Reinforcement, Psychology; Saccharin; Self Administration

2011
Ontogenetic differences in ethanol's motivational properties during infancy.
    Alcohol (Fayetteville, N.Y.), 2012, Volume: 46, Issue:3

    Topics: Age Factors; Animals; Animals, Newborn; Avoidance Learning; Conditioning, Operant; Conditioning, Psychological; Ethanol; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Saccharin

2012
Role of NMDA, opioid and dopamine D1 and D2 receptor signaling in the acquisition of a quinine-conditioned flavor avoidance in rats.
    Physiology & behavior, 2014, Apr-10, Volume: 128

    Topics: Animals; Avoidance Learning; Benzazepines; Conditioning, Psychological; Dizocilpine Maleate; Dopamine D2 Receptor Antagonists; Fructose; Male; Naltrexone; Narcotic Antagonists; Quinine; Raclopride; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, N-Methyl-D-Aspartate; Saccharin; Signal Transduction; Taste

2014
Evaluation of saccharin intake and expression of fructose-conditioned flavor preferences following opioid receptor antagonism in the medial prefrontal cortex, amygdala or lateral hypothalamus in rats.
    Neuroscience letters, 2014, Apr-03, Volume: 564

    Topics: Amygdala; Animals; Conditioning, Psychological; Drinking Behavior; Food Preferences; Fructose; Hypothalamus; Male; Naltrexone; Narcotic Antagonists; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Saccharin

2014
Delta-opioid receptor blockade in the ventral pallidum increases perceived palatability and consumption of saccharin solution in rats.
    Behavioural brain research, 2014, Aug-01, Volume: 269

    Topics: Animals; Avoidance Learning; Basal Forebrain; Conditioning, Psychological; Dose-Response Relationship, Drug; Drinking; Eating; Male; Motor Activity; Naltrexone; Narcotic Antagonists; Rats, Wistar; Receptors, Opioid, delta; Saccharin; Taste Perception

2014
Wistar rats acquire and maintain self-administration of 20 % ethanol without water deprivation, saccharin/sucrose fading, or extended access training.
    Psychopharmacology, 2014, Volume: 231, Issue:23

    Topics: Animals; Behavior, Animal; Conditioning, Operant; Ethanol; Male; Motivation; Naltrexone; Rats; Rats, Wistar; Reinforcement, Psychology; Reward; Saccharin; Self Administration; Sucrose; Water Deprivation

2014
Dopamine D1 and opioid receptor antagonist-induced reductions of fructose and saccharin intake in BALB/c and SWR inbred mice.
    Pharmacology, biochemistry, and behavior, 2015, Volume: 131

    Topics: Animals; Benzazepines; Dietary Carbohydrates; Dose-Response Relationship, Drug; Fructose; Male; Mice, Inbred BALB C; Mice, Inbred Strains; Naltrexone; Narcotic Antagonists; Receptors, Dopamine D1; Receptors, Opioid; Saccharin; Species Specificity; Sweetening Agents

2015
Oral operant ethanol self-administration in the absence of explicit cues, food restriction, water restriction and ethanol fading in C57BL/6J mice.
    Psychopharmacology, 2015, Volume: 232, Issue:20

    Topics: Administration, Oral; Alcohol Drinking; Animals; Conditioning, Operant; Cues; Ethanol; Food Deprivation; Male; Mice; Mice, Inbred C57BL; Naltrexone; Reinforcement, Psychology; Saccharin; Self Administration; Water

2015
Combination of Clinically Utilized Kappa-Opioid Receptor Agonist Nalfurafine With Low-Dose Naltrexone Reduces Excessive Alcohol Drinking in Male and Female Mice.
    Alcoholism, clinical and experimental research, 2019, Volume: 43, Issue:6

    Topics: Alcohol Deterrents; Alcohol Drinking; Alcohol-Related Disorders; Animals; Drug Evaluation, Preclinical; Drug Tolerance; Female; Male; Mice, Inbred C57BL; Morphinans; Naltrexone; Receptors, Opioid, kappa; Saccharin; Spiro Compounds; Sucrose

2019
Effects of naltrexone on alcohol, sucrose, and saccharin binge-like drinking in C57BL/6J mice: a study with a multiple bottle choice procedure.
    Behavioural pharmacology, 2020, Volume: 31, Issue:2&3

    Topics: Animals; Behavior, Addictive; Binge Drinking; Binge-Eating Disorder; Ethanol; Male; Mice; Mice, Inbred C57BL; Models, Animal; Naltrexone; Narcotic Antagonists; Saccharin; Self Administration; Sucrose

2020
Saccharin and naltrexone prevent increased pain sensitivity and impaired long-term memory induced by repetitive neonatal noxious stimulation: role of BDNF and enkephalin.
    Naunyn-Schmiedeberg's archives of pharmacology, 2021, Volume: 394, Issue:8

    Topics: Analgesics; Animals; Animals, Newborn; Brain-Derived Neurotrophic Factor; Enkephalins; Hippocampus; Male; Maze Learning; Memory, Long-Term; Naltrexone; Narcotic Antagonists; Pain; Pain Threshold; Rats; Rats, Wistar; Saccharin

2021
The serotonin 2C receptor agonist lorcaserin, alone and in combination with the opioid receptor antagonist naltrexone, attenuates binge-like ethanol drinking.
    Addiction biology, 2021, Volume: 26, Issue:5

    Topics: Animals; Benzazepines; Binge Drinking; Dose-Response Relationship, Drug; Ethanol; Male; Mice; Mice, Inbred C57BL; Models, Animal; Naltrexone; Narcotic Antagonists; Receptor, Serotonin, 5-HT2C; Saccharin; Self Administration; Serotonin 5-HT2 Receptor Agonists

2021
Differential patterns of opioid and dopamine D1 receptor antagonism on nutritive and non-nutritive sweetener intakes in C57BL/6:129 hybrid mice relative to inbred C57BL/6 and 129 mice.
    Pharmacology, biochemistry, and behavior, 2023, Volume: 223

    Topics: Analgesics, Opioid; Animals; Dopamine Antagonists; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Inbred Strains; Naltrexone; Narcotic Antagonists; Non-Nutritive Sweeteners; Receptors, Dopamine D1; Saccharin; Sucrose; Sweetening Agents

2023