naltrexone and oxymorphone

naltrexone has been researched along with oxymorphone in 55 studies

Research

Studies (55)

TimeframeStudies, this research(%)All Research%
pre-199027 (49.09)18.7374
1990's9 (16.36)18.2507
2000's7 (12.73)29.6817
2010's11 (20.00)24.3611
2020's1 (1.82)2.80

Authors

AuthorsStudies
Berkowitz, DS; Loew, GH1
Klein, P; Nelson, WL1
Archer, S; Corbett, AD; Kosterlitz, HW; McKnight, AT; Paterson, SJ; Seyed-Mozaffari, A; Ward, S1
Lipkowski, AW; Portoghese, PS; Tam, SW1
Hahn, EF; Pasternak, GW1
Strassburg, CP; Tukey, RH1
Ferguson, DM; Metzger, TG; Paterlini, MG; Portoghese, PS1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Fujii, H; Hasebe, K; Izumimoto, N; Mochizuki, H; Momen, S; Nagase, H; Nakajima, R; Nemoto, T; Yamamoto, N1
Burgman, M; Grinnell, S; Haselton, N; Le Rouzic, V; Majumdar, S; Nagakura, K; Ocampo, J; Pan, YX; Pasternak, AR; Pasternak, GW; Polikar, L; Subrath, J1
England, PM; Harvey, JH; Long, DH; Whistler, JL1
Coop, A; Cunningham, CW; Eddington, ND; Hassan, HE; Mercer, SL; Metcalf, MD; Rosicky, AD1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Brockmöller, J; Friesacher, HR; Meyer, MJ; Neumann, VE; Tzvetkov, MV; Zdrazil, B1
Fishman, J; Foldes, FF; Hahn, EF; Ronai, AZ1
Caruso, TP; Larson, DL; Portoghese, PS; Takemori, AE2
Bykov, V; Holaday, JW; Jacobson, AE; Long, JB; Rice, KC; Rothman, RB1
Leander, JD; Mayer-Valkanover, K; Nussbaumer, C; Schmidhammer, H; Schmidt, C; Schoepp, DD; Schratz, A; Walla-Kugler, M1
Angel, L; Appelmans, N; Gioannini, TL; Koolpe, GA; Nelson, WL; Simon, EJ1
Goodman, RR; Hahn, EF; Nishimura, S; Pasternak, GW1
Einarsson, M; Koman, A; Terenius, L1
Galetta, S; Hahn, EF; Nishimura, S; Pasternak, GW1
Botros, S; Larson, DL; Lipkowski, AW; Portoghese, PS; Stark, PA; Takemori, AE1
Belluzzi, JD; Stein, L; Trujillo, KA1
Abdelhamid, EM; Archer, S; Koolpe, GA; Michael, J; Michael, M; Nelson, WL; Simon, EJ1
Cho, TM; Nozaki, M1
Larson, DL; Lipkowski, AW; Portoghese, PS; Rice, KC; Ronsisvalle, G; Sayre, LM; Takemori, AE; Tam, SW; Yim, CB1
Jacobson, AE; Rice, KC; Sadée, W; Yu, VC1
Armstrong, MJ; Larson, AA1
Carroll-Buatti, M; Hahn, EF; Pasternak, GW1
Giles, T; Merz, H; Sander, G1
France, CP; Jacobson, AE; Woods, JH2
Angel, L; Gioannini, TL; Koolpe, GA; Nelson, WL; Simon, EJ1
Fries, DS; Larson, DL; Portoghese, PS; Sayre, LM; Takemori, AE1
Larson, DL; Portoghese, PS; Takemori, AE1
Pasternak, GW1
Bowen, WD; Pert, CB; Rothman, RB; Schumacher, UK1
Gao, P1
DiGiacomo, B; Larson, DL; Ohkawa, S; Portoghese, PS; Takemori, AE1
Fang, X; Larson, DL; Portoghese, PS1
Fang, X; Kshirsagar, TA; Portoghese, PS1
Gao, P; Larson, DL; Portoghese, PS1
Borsodi, A; Hosztafi, S; Nevin, ST; Rónai, AZ; Spetea, M; Tóth, G1
Jones, RM; McCurdy, CR; Portoghese, PS1
Adams, M; Ahdieh, H; Gammaitoni, AR; Pieniaszek, HJ1
Daniels, DJ; Lenard, NR; Portoghese, PS; Roerig, SC1
Crawford, D; Lasukova, TV; Lishmanov, AY; Maslov, LN; Wong, TM1
Virk, MS; Williams, JT1
Al-Khrasani, M; Asim, MF; Friedmann, T; Furst, S; Király, KP; Riba, P; Schmidhammer, H; Sobor, M; Spetea, M1
Pappagallo, M; Sokolowska, M1
Hosztafi, S; Mazák, K; Noszál, B1
Ahrens, B; Kucherova, Y; Sobolevsky, T1
Cunningham, CW; France, CP; Gerak, LR; Hu, Z; Mada, S; Maguire, DR; Minervini, V; Soyer, A1

Reviews

2 review(s) available for naltrexone and oxymorphone

ArticleYear
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
    Annual review of pharmacology and toxicology, 2000, Volume: 40

    Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic

2000
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

1 trial(s) available for naltrexone and oxymorphone

ArticleYear
Oxymorphone extended release does not affect CYP2C9 or CYP3A4 metabolic pathways.
    Journal of clinical pharmacology, 2005, Volume: 45, Issue:3

    Topics: Adolescent; Adult; Analgesics, Opioid; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Delayed-Action Preparations; Drug Interactions; Erythromycin; Female; Humans; Male; Midazolam; Middle Aged; Naltrexone; Oxymorphone; Rifampin; Tolbutamide

2005

Other Studies

52 other study(ies) available for naltrexone and oxymorphone

ArticleYear
Quantum chemical studies of N-substituent variation in the oxymorphone series of opiate narcotics.
    Journal of medicinal chemistry, 1978, Volume: 21, Issue:1

    Topics: Analgesics, Opioid; Animals; Hydromorphone; In Vitro Techniques; Mice; Molecular Conformation; Oxymorphone; Quantum Theory; Rats; Structure-Activity Relationship; Swine; Thermodynamics

1978
O3-(2-carbomethoxyallyl) ethers of opioid ligands derived from oxymorphone, naltrexone, etorphine, diprenorphine, norbinaltorphimine, and naltrindole. Unexpected O3-dealkylation in the opioid radioligand displacement assay.
    Journal of medicinal chemistry, 1992, Nov-27, Volume: 35, Issue:24

    Topics: Alkylation; Animals; Brain; Diprenorphine; Drug Stability; Ethers; Etorphine; Guinea Pigs; Indoles; Methacrylates; Molecular Structure; Morphinans; Naltrexone; Narcotic Antagonists; Narcotics; Oxymorphone; Phenols; Radioligand Assay; Receptors, Opioid; Tritium

1992
10-Ketonaltrexone and 10-ketooxymorphone.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:7

    Topics: Animals; Biological Assay; Brain; Chemical Phenomena; Chemistry; Guinea Pigs; Hydromorphone; Ileum; Male; Mice; Naloxone; Naltrexone; Oxymorphone; Receptors, Opioid; Structure-Activity Relationship; Vas Deferens

1985
Peptides as receptor selectivity modulators of opiate pharmacophores.
    Journal of medicinal chemistry, 1986, Volume: 29, Issue:7

    Topics: Animals; Dynorphins; Endorphins; Enkephalin, Leucine; Guinea Pigs; Indicators and Reagents; Kinetics; Oligopeptides; Receptors, Opioid; Structure-Activity Relationship

1986
Long-acting opiate agonists and antagonists: 14-hydroxydihydromorphinone hydrazones.
    Journal of medicinal chemistry, 1980, Volume: 23, Issue:6

    Topics: Analgesics, Opioid; Animals; Brain; Delayed-Action Preparations; Hydrazones; Hydromorphone; In Vitro Techniques; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Oxymorphone; Rats; Receptors, Opioid

1980
Investigation of the selectivity of oxymorphone- and naltrexone-derived ligands via site-directed mutagenesis of opioid receptors: exploring the "address" recognition locus.
    Journal of medicinal chemistry, 2001, Mar-15, Volume: 44, Issue:6

    Topics: Amino Acid Sequence; Base Sequence; Binding, Competitive; Cell Line; Humans; Ligands; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Naltrexone; Narcotic Antagonists; Oxymorphone; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu

2001
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Synthesis of new opioid derivatives with a propellane skeleton and their pharmacology: part 1.
    Bioorganic & medicinal chemistry letters, 2011, Jul-01, Volume: 21, Issue:13

    Topics: Analgesics, Opioid; Animals; Bridged-Ring Compounds; Cells, Cultured; Mice; Molecular Structure; Protein Binding; Receptors, Opioid, kappa; Structure-Activity Relationship; Substrate Specificity

2011
Synthesis and evaluation of aryl-naloxamide opiate analgesics targeting truncated exon 11-associated μ opioid receptor (MOR-1) splice variants.
    Journal of medicinal chemistry, 2012, Jul-26, Volume: 55, Issue:14

    Topics: Amides; Analgesics; Animals; Behavior, Animal; Brain; Cell Line; Chemistry Techniques, Synthetic; Exons; Male; Mice; Opiate Alkaloids; Protein Isoforms; Protein Structure, Tertiary; Receptors, Opioid, mu; Structure-Activity Relationship

2012
Tuned-Affinity Bivalent Ligands for the Characterization of Opioid Receptor Heteromers.
    ACS medicinal chemistry letters, 2012, Aug-09, Volume: 3, Issue:8

    Topics:

2012
Opioids and efflux transporters. Part 4: influence of N-substitution on P-glycoprotein substrate activity of noroxymorphone analogues.
    Bioorganic & medicinal chemistry letters, 2014, Aug-01, Volume: 24, Issue:15

    Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Dose-Response Relationship, Drug; Humans; Models, Molecular; Molecular Conformation; Morphinans; Structure-Activity Relationship

2014
Opioids as Substrates and Inhibitors of the Genetically Highly Variable Organic Cation Transporter OCT1.
    Journal of medicinal chemistry, 2019, 11-14, Volume: 62, Issue:21

    Topics: Analgesics, Opioid; HEK293 Cells; Humans; Inhibitory Concentration 50; Models, Molecular; Organic Cation Transporter 1; Permeability; Protein Conformation

2019
Orientation of the oxygen atom at C-6 as a determinant of agonistic activity in the oxymorphone series.
    The Journal of pharmacology and experimental therapeutics, 1977, Volume: 200, Issue:3

    Topics: Animals; Guinea Pigs; Hydromorphone; Male; Naloxone; Naltrexone; Narcotic Antagonists; Oxygen; Oxymorphone; Structure-Activity Relationship

1977
Chloroxymorphamine, and opioid receptor site-directed alkylating agent having narcotic agonist activity.
    Science (New York, N.Y.), 1979, Apr-20, Volume: 204, Issue:4390

    Topics: Alkylating Agents; Animals; Chlorambucil; Dose-Response Relationship, Drug; Drug Synergism; Guinea Pigs; Hydromorphone; In Vitro Techniques; Morphine; Naloxone; Naltrexone; Nitrogen Mustard Compounds; Norepinephrine; Oxymorphone; Phenoxybenzamine; Receptors, Opioid

1979
Pretreatment of rats with the irreversible mu-receptor antagonist, beta-FNA, fails to prevent naltrexone-induced upregulation of mu-opioid receptors.
    Neuropharmacology, 1990, Volume: 29, Issue:9

    Topics: Animals; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; In Vitro Techniques; Isothiocyanates; Kinetics; Naltrexone; Narcotic Antagonists; Oxymorphone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Thiocyanates; Up-Regulation

1990
5-Methylated naloxone, naltrexone, oxymorphone, and their 14-O-methyl ethers.
    Progress in clinical and biological research, 1990, Volume: 328

    Topics: Animals; Ethers; In Vitro Techniques; Methylation; Naloxone; Naltrexone; Narcotic Antagonists; Oxymorphone; Quaternary Ammonium Compounds; Receptors, Opioid; Structure-Activity Relationship

1990
Opioid agonists and antagonists. 6-Desoxy-6-substituted lactone, epoxide, and glycidate ester derivatives of naltrexone and oxymorphone.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:7

    Topics: Animals; Binding, Competitive; Brain; Chemical Phenomena; Chemistry; Circular Dichroism; Epoxy Compounds; Ethers, Cyclic; Hydromorphone; Lactones; Male; Naloxone; Naltrexone; Oxymorphone; Propionates; Rats; Rats, Inbred Strains; Receptors, Opioid; Structure-Activity Relationship

1985
Irreversible opiate agonists and antagonists. II. Evidence against a bivalent mechanism of action for opiate azines and diacylhydrazones.
    The Journal of pharmacology and experimental therapeutics, 1985, Volume: 235, Issue:3

    Topics: Animals; Binding, Competitive; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hydromorphone; In Vitro Techniques; Male; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Oxymorphone; Rats; Rats, Inbred Strains; Receptors, Opioid; Structure-Activity Relationship

1985
Agonist-antagonist properties of fluorescent opioid probes in the guinea-pig myenteric plexus-longitudinal muscle preparation.
    Naunyn-Schmiedeberg's archives of pharmacology, 1985, Volume: 331, Issue:4

    Topics: Animals; Chemical Phenomena; Chemistry; Depression, Chemical; Fluorescent Dyes; Guinea Pigs; Hydromorphone; Ileum; In Vitro Techniques; Male; Naloxone; Naltrexone; Oxymorphone; Receptors, Opioid; Stereoisomerism; Stimulation, Chemical

1985
Oxymorphone-naltrexonazine, a mixed opiate agonist-antagonist.
    Life sciences, 1987, Aug-10, Volume: 41, Issue:6

    Topics: Analgesia; Animals; Binding, Competitive; Brain; Dihydromorphine; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hydromorphone; Male; Mice; Mice, Inbred ICR; Naltrexone; Oxymorphone; Rats; Rats, Inbred Strains; Receptors, Opioid; Sodium

1987
Opioid agonist and antagonist activities of peripherally selective derivatives of naltrexamine and oxymorphamine.
    Journal of medicinal chemistry, 1989, Volume: 32, Issue:9

    Topics: Animals; Chemical Phenomena; Chemistry; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Guinea Pigs; Hydromorphone; Male; Mice; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Oxymorphone; Pain; Structure-Activity Relationship

1989
Effects of opiate antagonists and their quaternary analogues on nucleus accumbens self-stimulation.
    Behavioural brain research, 1989, Jun-01, Volume: 33, Issue:2

    Topics: Animals; Brain Mapping; Male; Motivation; Naloxone; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Oxymorphone; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Receptors, Opioid; Self Stimulation; Septal Nuclei

1989
Chloroacryloyl amides and alpha-methylenelactones from naltrexone, oxymorphone and fentanyl.
    Neuropeptides, 1985, Volume: 5, Issue:4-6

    Topics: Acrylates; Animals; Binding Sites; Brain; Chemical Phenomena; Chemistry; Fentanyl; Hydromorphone; In Vitro Techniques; Membranes; Naloxone; Naltrexone; Oxymorphone; Rats; Stereoisomerism

1985
Effects of 5,5'-dithiobis-(2-nitrobenzoic acid) on opiate binding to both the membrane-bound receptor and the partially purified opiate receptor.
    Journal of neurochemistry, 1985, Volume: 45, Issue:2

    Topics: Animals; Butorphanol; Cell Membrane; Dihydromorphine; Diprenorphine; Dithionitrobenzoic Acid; Dithiothreitol; Etorphine; Morphine; Nalorphine; Naloxone; Naltrexone; Nitrobenzoates; Oxymorphone; Rats; Receptors, Opioid

1985
Stereostructure-activity relationship of opioid agonist and antagonist bivalent ligands. Evidence for bridging between vicinal opioid receptors.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:9

    Topics: Animals; Brain; Chemical Phenomena; Chemistry; Endorphins; Guinea Pigs; Ileum; Naltrexone; Oxymorphone; Receptors, Opioid; Stereoisomerism; Structure-Activity Relationship

1985
Stereospecificity of 4,5-epoxymorphinan binding to the lambda site in rat brain.
    European journal of pharmacology, 1984, May-18, Volume: 101, Issue:1-2

    Topics: Animals; Binding, Competitive; Brain; In Vitro Techniques; Male; Morphinans; Morphine; Naloxone; Naltrexone; Narcotics; Oxymorphone; Rats; Rats, Inbred Strains; Receptors, Opioid; Stereoisomerism

1984
Morphine analgesia after intrathecal administration of a narcotic agonist, chloroxymorphamine and antagonist, chlornaltrexamine.
    European journal of pharmacology, 1980, Nov-07, Volume: 68, Issue:1

    Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Interactions; Hydromorphone; Injections, Spinal; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Nitrogen Mustard Compounds; Oxymorphone; Rats

1980
Pharmacological studies with an alkylating narcotic agonist, chloroxymorphamine, and antagonist, chlornaltrexamine.
    The Journal of pharmacology and experimental therapeutics, 1980, Volume: 213, Issue:3

    Topics: Analgesics; Animals; Brain; Hydromorphone; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Nitrogen Mustard Compounds; Oxymorphone

1980
Irreversible opiate agonists and antagonists: the 14-hydroxydihydromorphinone azines.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1982, Volume: 2, Issue:5

    Topics: Animals; Brain; Cell Membrane; Dihydromorphine; Drug Stability; Hydromorphone; Kinetics; Naloxone; Naltrexone; Oxymorphone; Receptors, Opioid; Structure-Activity Relationship

1982
Quaternary opiate antagonists lower blood pressure and inhibit leucine-enkephalin responses.
    European journal of pharmacology, 1983, Nov-25, Volume: 95, Issue:3-4

    Topics: Animals; Blood Pressure; Dogs; Dose-Response Relationship, Drug; Enkephalin, Leucine; Heart Rate; Hydromorphone; Naloxone; Naltrexone; Oxymorphone; Quaternary Ammonium Compounds

1983
Discriminative stimulus effects of reversible and irreversible opiate agonists: morphine, oxymorphazone and buprenorphine.
    The Journal of pharmacology and experimental therapeutics, 1984, Volume: 230, Issue:3

    Topics: Animals; Buprenorphine; Columbidae; Discrimination Learning; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Hydromorphone; Morphinans; Morphine; Naltrexone; Oxymorphone; Time Factors

1984
Irreversible and reversible narcotic agonists: discriminative and analgesic effects of buprenorphine, oxymorphazone, and morphine.
    NIDA research monograph, 1984, Volume: 49

    Topics: Animals; Buprenorphine; Columbidae; Discrimination Learning; Dose-Response Relationship, Drug; Hydromorphone; Mice; Morphinans; Morphine; Naltrexone; Nociceptors; Oxymorphone

1984
Diastereomeric 6-desoxy-6-spiro-alpha-methylene-gamma-butyrolactone derivatives of naltrexone and oxymorphone. Selective irreversible inhibition of naltrexone binding in an opioid receptor preparation by a conformationally restricted michael acceptor liga
    Journal of medicinal chemistry, 1984, Volume: 27, Issue:12

    Topics: Animals; Brain; Cell Membrane; Chromatography, Thin Layer; Hydromorphone; Indicators and Reagents; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Molecular Conformation; Naloxone; Naltrexone; Narcotic Antagonists; Optical Rotation; Oxymorphone; Rats; Rats, Inbred Strains; Receptors, Opioid; Structure-Activity Relationship

1984
A novel opioid receptor site directed alkylating agent with irreversible narcotic antagonistic and reversible agonistic activities.
    Journal of medicinal chemistry, 1980, Volume: 23, Issue:3

    Topics: Alkylating Agents; Animals; Guinea Pigs; In Vitro Techniques; Morphinans; Muscle Contraction; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Narcotics; Oxymorphone; Receptors, Opioid

1980
The irreversible narcotic antagonistic and reversible agonistic properties of the fumaramate methyl ester derivative of naltrexone.
    European journal of pharmacology, 1981, Apr-09, Volume: 70, Issue:4

    Topics: Affinity Labels; Animals; Ileum; Male; Mice; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Oxymorphone; Receptors, Opioid; Structure-Activity Relationship

1981
Opiate, enkephalin, and endorphin analgesia: relations to a single subpopulation of opiate receptors.
    Neurology, 1981, Volume: 31, Issue:10

    Topics: Analgesia; Animals; Humans; Lethal Dose 50; Morphine; Muridae; Naloxone; Naltrexone; Oxymorphone; Receptors, Opioid; Respiration; Respiratory Insufficiency

1981
Effect of beta-FNA on opiate receptor binding: preliminary evidence for two types of mu receptors.
    European journal of pharmacology, 1983, Nov-11, Volume: 95, Issue:1-2

    Topics: Animals; Brain; In Vitro Techniques; Naloxone; Naltrexone; Oxymorphone; Rats; Receptors, Opioid; Receptors, Opioid, mu

1983
Comparison of cyclic delta-opioid peptides with non-peptide delta-agonist spiroindanyloxymorphone (SIOM) using the message-address concept: a molecular modeling study.
    Journal of computer-aided molecular design, 1996, Volume: 10, Issue:4

    Topics: Drug Design; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ligands; Magnetic Resonance Spectroscopy; Models, Molecular; Naltrexone; Narcotic Antagonists; Oxymorphone; Peptides, Cyclic; Protein Binding; Protein Conformation; Receptors, Opioid, delta; Spiro Compounds; Structure-Activity Relationship

1996
7-Spiroindanyl derivatives of naltrexone and oxymorphone as selective ligands for delta opioid receptors.
    Journal of medicinal chemistry, 1997, May-23, Volume: 40, Issue:11

    Topics: Analgesia; Analgesics; Animals; Brain; Cell Membrane; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Ileum; Ligands; Male; Mice; Mice, Inbred ICR; Molecular Structure; Muscle, Smooth; Naltrexone; Oxymorphone; Receptors, Opioid, delta; Spiro Compounds; Vas Deferens

1997
7-spirobenzocyclohexyl derivatives of naltrexone, oxymorphone, and hydromorphone as selective opioid receptor ligands.
    Journal of medicinal chemistry, 1997, Sep-12, Volume: 40, Issue:19

    Topics: Animals; Electric Stimulation; Guinea Pigs; Hydromorphone; In Vitro Techniques; Ligands; Male; Mice; Molecular Conformation; Molecular Structure; Muscle Contraction; Muscle, Smooth; Naltrexone; Narcotics; Oxymorphone; Receptors, Opioid, delta; Spiro Compounds; Structure-Activity Relationship

1997
14-Desoxy analogues of naltrindole and 7-spiroindanyloxymorphone: the role of the 14-hydroxy group at delta opioid receptors.
    Journal of medicinal chemistry, 1998, Jul-02, Volume: 41, Issue:14

    Topics: Animals; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Muscle Contraction; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Oxymorphone; Receptors, Opioid, delta; Spiro Compounds; Vas Deferens

1998
Synthesis of 7-arylmorphinans. Probing the "address" requirements for selectivity at opioid delta receptors.
    Journal of medicinal chemistry, 1998, Jul-30, Volume: 41, Issue:16

    Topics: Animals; Electric Stimulation; Guinea Pigs; Ileum; In Vitro Techniques; Ligands; Male; Mice; Models, Molecular; Molecular Conformation; Morphinans; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Oxymorphone; Pain Measurement; Receptors, Opioid, delta; Spiro Compounds; Vas Deferens

1998
Affinity profiles of novel delta-receptor selective benzofuran derivatives of non-peptide opioids.
    Neurochemical research, 1998, Volume: 23, Issue:9

    Topics: Animals; Benzeneacetamides; Benzofurans; Binding, Competitive; Brain; Cell Membrane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Naloxone; Naltrexone; Oligopeptides; Oxycodone; Oxymorphone; Pyrrolidines; Radioligand Assay; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Tritium

1998
Investigation of phenolic bioisosterism in opiates: 3-sulfonamido analogues of naltrexone and oxymorphone.
    Organic letters, 2000, Mar-23, Volume: 2, Issue:6

    Topics: Indicators and Reagents; Models, Molecular; Molecular Conformation; Naltrexone; Narcotics; Oxymorphone; Stereoisomerism; Sulfonamides

2000
Absence of conditioned place preference or reinstatement with bivalent ligands containing mu-opioid receptor agonist and delta-opioid receptor antagonist pharmacophores.
    European journal of pharmacology, 2007, Jul-02, Volume: 566, Issue:1-3

    Topics: Analgesics, Opioid; Animals; Behavior, Animal; Conditioning, Psychological; Ligands; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Narcotic Antagonists; Oxymorphone; Pain; Receptors, Opioid, delta; Receptors, Opioid, mu

2007
Activation of kappa-opioid receptor as a method for prevention of ischemic and reperfusion arrhythmias: role of protein kinase C and K(ATP) channels.
    Bulletin of experimental biology and medicine, 2007, Volume: 143, Issue:2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Alkaloids; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzophenanthridines; Glyburide; Male; Myocardial Reperfusion Injury; Naltrexone; Oxymorphone; Potassium Channels; Protein Kinase C; Rats; Rats, Wistar; Receptors, Opioid, kappa

2007
Agonist-specific regulation of mu-opioid receptor desensitization and recovery from desensitization.
    Molecular pharmacology, 2008, Volume: 73, Issue:4

    Topics: Analgesics, Opioid; Animals; Down-Regulation; Electrophysiology; Enkephalins; Etorphine; Fentanyl; In Vitro Techniques; Male; Naltrexone; Oxymorphone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu

2008
Novel approach to demonstrate high efficacy of mu opioids in the rat vas deferens: a simple model of predictive value.
    Brain research bulletin, 2010, Jan-15, Volume: 81, Issue:1

    Topics: Analgesics, Opioid; Animals; Brain; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Male; Mice; Mice, Inbred Strains; Models, Biological; Morphine; Morphine Derivatives; Naltrexone; Oxymorphone; Pain; Rats; Rats, Wistar; Receptors, Opioid, mu; Vas Deferens

2010
The implications of tamper-resistant formulations for opioid rotation.
    Postgraduate medicine, 2012, Volume: 124, Issue:5

    Topics: Analgesics, Opioid; Chronic Pain; Delayed-Action Preparations; Drug Combinations; Drug Compounding; Drug Tolerance; Humans; Morphine; Naltrexone; Opioid-Related Disorders; Oxycodone; Oxymorphone; Patient Selection

2012
Species-specific lipophilicity of morphine antagonists.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2015, Oct-12, Volume: 78

    Topics: 1-Octanol; Hydrogen-Ion Concentration; Naloxone; Naltrexone; Narcotic Antagonists; Oxymorphone; Potentiometry; Water

2015
Identification of oxymorphone as decomposition product of the permitted drug methylnaltrexone.
    Drug testing and analysis, 2018, Volume: 10, Issue:5

    Topics: Doping in Sports; Drug Stability; Gas Chromatography-Mass Spectrometry; Humans; Naltrexone; Narcotic Antagonists; Narcotics; Oxymorphone; Quaternary Ammonium Compounds; Substance Abuse Detection

2018
Behavioral effects of benzylideneoxymorphone (BOM), a low efficacy µ opioid receptor agonist and a δ opioid receptor antagonist.
    Psychopharmacology, 2020, Volume: 237, Issue:12

    Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Male; Morphine; Naltrexone; Narcotic Antagonists; Oxymorphone; Pain; Pain Measurement; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Reinforcement, Psychology; Self Administration

2020