naltrexone has been researched along with norbinaltorphimine in 850 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (1.88) | 18.7374 |
| 1990's | 349 (41.06) | 18.2507 |
| 2000's | 275 (32.35) | 29.6817 |
| 2010's | 193 (22.71) | 24.3611 |
| 2020's | 17 (2.00) | 2.80 |
| Authors | Studies |
|---|---|
| Klein, P; Nelson, WL | 1 |
| Larson, DL; Lipkowski, AW; Nagase, H; Portoghese, PS; Takemori, AE | 1 |
| Nagase, H; Portoghese, PS; Takemori, AE | 1 |
| Befort, K; Bloch, B; Charron, G; Gavériaux-Ruff, C; Kieffer, B; Lannes, B; Mattéi, MG; Matthes, H; Micheletti, G; Simonin, F | 1 |
| Bell, GI; Breder, CD; Kong, H; Raynor, K; Reisine, T; Takeda, J; Yasuda, K | 1 |
| Adapa, ID; Auh, JS; Berzetei-Gurske, IP; Brandt, SR; Craymer, K; Farrington, L; Haggart, D; Kennedy, JM; O'Brien, A; Polgar, WE; Rodriguez, L; Schwartz, RW; Toll, L; White, A | 1 |
| Cantrell, BE; Carroll, FI; Cooper, JB; Dersch, CM; Fall, MJ; Mascarella, SW; McCullough, KB; Partilla, JS; Rothman, RB; Thomas, JB; Xu, H; Zimmerman, DM | 1 |
| Ferguson, DM; Metzger, TG; Paterlini, MG; Portoghese, PS | 2 |
| Grundt, P; Husbands, SM; Jales, AR; Lewis, JW; Traynor, JR | 1 |
| Carroll, FI | 1 |
| Grundt, P; Husbands, SM; Lewis, JW; Williams, IA | 1 |
| Carroll, FI; Chaudhari, S; Deschamps, J; Gigstad, KM; Mascarella, SW; Navarro, HA; Thomas, JB | 1 |
| Hebbel, RP; Lunzer, MM; Portoghese, PS; Yekkirala, A | 1 |
| Katavic, PL; Lamb, K; Navarro, H; Prisinzano, TE | 1 |
| Bidlack, JM; Bu, Y; Cohen, DJ; Lou, R; Lu, Q; VanAlstine, MA; Wentland, MP | 1 |
| Azar, MR; Cashman, JR; Ghirmai, S | 1 |
| Burgman, M; Grinnell, S; Haselton, N; Majumdar, S; Ocampo, J; Pasternak, AR; Pasternak, GW | 1 |
| Fujii, H; Kobayashi, S; Miyata, Y; Nagase, H; Osa, Y; Takeuchi, T | 1 |
| Clark, MJ; Husbands, SM; Kumar, V; Lewis, JW; Traynor, JR | 1 |
| Colloc'h, N; Perrio, C; Schmitt, S | 1 |
| Iwata, S; Koyama, Y; Kutsumura, N; Miyata, Y; Nagase, H; Nagumo, Y; Nakajima, R; Saitoh, T; Yamamoto, N; Yoshida, N | 1 |
| Bourgoin, S; Cesselin, F; Collin, E; Ferhat, L; Hamon, M; Mantelet, S; Mauborgne, A | 1 |
| Horan, P; Porreca, F; Taylor, J; Yamamura, HI | 1 |
| Pinnock, RD | 2 |
| Kane, K; McIntosh, M; Parratt, J | 2 |
| Portoghese, PS; Sofuoglu, M; Takemori, AE | 1 |
| Berzetei-Gurske, IP; Toll, L | 1 |
| LaVigne, SD; Lookingland, KJ; Manzanares, J; Moore, KE; Wagner, EJ | 1 |
| Bristow, AF; Das, RE; Ferreira, SH; Lorenzetti, BB; Poole, S; Smith, TW | 1 |
| Gallo, RV; Zhen, S | 3 |
| Holtzman, SG; Jones, DN | 1 |
| Leyton, M; Stewart, J | 1 |
| Bansinath, M; Puig, MM; Tang, CK; Turndorf, H; Warner, W | 1 |
| Le, AD; Poulos, CX; Walker, MJ | 1 |
| Caudle, RM; Chavkin, C; Wagner, JJ | 1 |
| Herz, A; Shippenberg, TS; Spanagel, R | 1 |
| Fujimoto, JM; Holmes, BB | 2 |
| Bodnar, RJ; Kest, B; Orlowski, M | 1 |
| Ingenito, AJ; Wang, JQ | 4 |
| Song, SH; Takemori, AE | 1 |
| Cometta-Morini, C; Kamal, J; Loew, G; Maguire, P; Tsai, N; Upton, C | 1 |
| Bennett, EL; Colombo, PJ; Martinez, JL; Rosenzweig, MR | 1 |
| Katafuchi, T; Koizumi, K; Nagatomo, I | 1 |
| Bakshi, R; Faden, AI; Ni, RX | 1 |
| Larson, AA; Mousseau, DD; Sun, X | 1 |
| Misawa, M; Nagase, H; Narita, M; Suzuki, T; Takahashi, Y | 1 |
| Melzack, R; Plamondon, H; Vaccarino, AL | 1 |
| Misawa, M; Nagase, H; Narita, M; Suzuki, T | 3 |
| Jackson, HC; Nutt, DJ | 1 |
| Chalmers, J; Drolet, G; Morilak, DA | 1 |
| Hattori, Y; Katafuchi, T; Koizumi, K; Nagatomo, I | 1 |
| Adamson, WT; Blackford, S; Kuhn, CM; Windh, RT | 1 |
| Aleman, DO; Bak, TH; Carr, KD; Simon, EJ | 1 |
| Agbas, A; Ahmed, MS; Cemerikic, B; Cheng, J | 1 |
| Kaneto, H; Takahashi, M | 1 |
| Bilotta, JM; Brackeen, MF; Feldman, PL; James, MK; Leighton, HJ; Schuster, SV | 1 |
| Arjune, D; Bodnar, RJ; Bowen, WD | 1 |
| Kaneto, H; Senda, T; Takahashi, M | 1 |
| Baumann, MH; Rabii, J | 1 |
| Furuya, Y; Kaneko, T; Nakazawa, T; Yamatsu, K | 1 |
| Shiotsu, G; Stein, L; Stevens, KE | 1 |
| Gannon, RL; Terrian, DM | 1 |
| Godin, C; Henry, JL; Rochford, J | 1 |
| Kromer, W | 3 |
| LaVigne, SD; Lookingland, KJ; Manzanares, J; Moore, KE | 1 |
| Song, ZH; Takemori, AE | 1 |
| Garzon-Aburbeh, A; Lin, CE; Nagase, H; Portoghese, PS; Takemori, AE | 1 |
| Giordano, J; Hughes, RA; Sufka, KJ | 1 |
| Kaneto, H; Takahashi, M; Watanabe, J | 1 |
| Arjune, D; Bodnar, RJ; Pasternak, GW; Standifer, KM | 1 |
| Arjune, D; Bodnar, RJ | 1 |
| Billington, CJ; Grace, M; Levine, AS; Portoghese, PS | 2 |
| Hughes, J; Hunter, JC; Singh, L; Vass, CA; Woodruff, GN | 1 |
| Faden, AI | 1 |
| Arts, KS; Fujimoto, JM | 1 |
| Koehler, E; McLemore, GL; Rosella-Dampman, LM; Summy-Long, JY | 1 |
| Bakshi, R; Faden, AI; Newman, AH | 1 |
| Cowan, A; Murray, CW | 1 |
| Fukagawa, Y; Misawa, M; Nagase, H; Suzuki, T | 2 |
| DeCosta, B; Hollingsworth, PJ; Medzihradsky, F; Rice, KC; Smith, CB; Woods, JH | 1 |
| Barbas, DP; Portoghese, PS; Song, ZH; Takemori, AE | 1 |
| Magnan, J; Tiberi, M | 1 |
| Best, JA; Chen, DC; Portoghese, PS; Quock, RM; Takemori, AE; Vaughn, LK | 1 |
| Heijna, MH; Hogenboom, F; Mulder, AH; Padt, M; Portoghese, PS; Schoffelmeer, AN | 1 |
| Kamei, J; Kasuya, Y; Tanihara, H | 1 |
| Calcagnetti, DJ; Calcagnetti, RL; Fanselow, MS | 1 |
| Echevarria, E; Holaday, JW; Lipkowski, AW; Portoghese, PS; Takemori, AE; Tortella, FC | 1 |
| Bak, TH; Carr, KD; Portoghese, PS; Simon, EJ | 1 |
| Evans, RG; Ludbrook, J; Van Leeuwen, AF | 1 |
| Bals-Kubik, R; Herz, A; Shippenberg, TS | 1 |
| Calcagnetti, DJ; Fanselow, MS; Helmstetter, FJ | 1 |
| Fujimoto, JM; Rady, JJ | 2 |
| Birch, PJ; Hayes, AG; Sheehan, MJ; Tyers, MB | 1 |
| Ho, BY; Naeseth, JS; Portoghese, PS; Takemori, AE | 1 |
| Cox, BM; Frattali, A; Portoghese, PS; Takemori, AE; Werling, LL | 1 |
| Portoghese, PS; Schwartz, MM; Takemori, AE | 1 |
| Gintzler, AR; Portoghese, PS; Sander, HW | 1 |
| Bykov, V; De Costa, BR; Jacobson, AE; Newman, AH; Reid, A; Rice, KC; Rothman, RB | 1 |
| Lipkowski, AW; Portoghese, PS; Takemori, AE | 1 |
| Faden, AI; Portoghese, PS; Takemori, AE | 1 |
| Laorden, ML; Llobell, F | 1 |
| Cosentino, M; De Ponti, F; Frigo, G; Giaroni, C; Lecchini, S; Leoni, O; Marino, F; Somaini, L | 1 |
| Collins, KA; Portoghese, PS; Tsai, JH; Tseng, LF | 1 |
| Berzetei-Gurske, IP; DeCosta, BR; Pasternak, GW; Polgar, W; Toll, L; White, A | 1 |
| Guilbaud, G; Kayser, V; Keïta, H | 1 |
| Fukuda, K; Fukushima, N; Misu, Y; Miyamae, T; Sasaki, Y; Takeshima, H; Ueda, H | 1 |
| Hiramatsu, M; Kameyama, T; Sasaki, M | 1 |
| Kamei, J; Kasuya, Y; Saitoh, A | 1 |
| Armstead, WM | 2 |
| Akaike, A; Fukuda, K; Kaneko, S; Mori, Y; Satoh, M; Yada, N | 1 |
| Chen, L; Gu, Y; Huang, LY | 1 |
| Grandy, DK; Hjorth, SA; Schwartz, TW; Thirstrup, K | 1 |
| Archer, S; Glick, SD; Maisonneuve, IM; Raucci, J | 1 |
| Brotchie, JM; Crossman, AR; Maneuf, YP; Mitchell, IJ; Woodruff, GN | 1 |
| Duan, N; Kapusta, DR; Minor, LD; Mosaddeghi, M; Paul, D | 1 |
| Fujinami, T; Nishimura, M; Saeki, T; Sato, N; Watanabe, Y | 1 |
| Bodnar, RJ; Cole, JL; Kirkham, TC; Leventhal, L | 1 |
| Han, JS; Jen, MF; Xue, JC; Yu, YX | 1 |
| Chavkin, C; Gibbs, SM; Simmons, ML; Terman, GW | 1 |
| Tripathi, A; Welch, SP | 1 |
| Adler, MW; Bussiere, JL; Eisenstein, TK; Geller, EB; Meissler, JJ; Rogers, TJ | 1 |
| Lemaire, S; Shukla, VK | 1 |
| Bodnar, RJ; Glass, MJ; Koch, JE | 1 |
| Martín, MI; Milanés, MV; Vargas, ML | 1 |
| Diop, L; Junien, JL; Pascaud, X; Rivière, PJ | 1 |
| Chavkin, C; Davidson, N; Grandy, DK; Henry, DJ; Lester, HA | 1 |
| Kradel, BK; Monroe, PJ; Smith, DJ; Smith, DL | 1 |
| Kuznetsov, A; Ma, GH; Miller, RJ; Philipson, LH | 1 |
| Donatini, A; Ferri, S; Lesa, G; Romualdi, P | 1 |
| Lewis, DV; Xie, CW | 1 |
| Kamei, J; Kasuya, Y; Misawa, M; Nagase, H; Suzuki, T | 1 |
| Coenen, A; Lasoń, W; Machelska, H; Przewłocka, B; Przewłocki, R; van Luijtelaar, G | 1 |
| Coderre, TJ; Henry, JL; Pitcher, GM; Yashpal, K | 1 |
| Bodnar, RJ; Glass, MJ; Hahn, B; Joseph, A | 1 |
| Almeida, OF; Shippenberg, TS; Spanagel, R | 1 |
| Archer, S; Bidlack, JM; el-Hamouly, W; Lawrence, DM; Leary, JF | 1 |
| Almeida, OF; Bartl, C; Shippenberg, TS; Spanagel, R | 1 |
| Adler, MW; Eisenstein, TK; Guan, L; Rogers, TJ; Townsend, R | 1 |
| Carr, KD; Papadouka, V; Wolinsky, TD | 1 |
| Broadbear, JH; Butelman, ER; de Costa, BR; Negus, SS; Woods, JH | 1 |
| Avidor-Reiss, T; Barg, J; Ezra, V; Levy, R; Matus-Leibovitch, N; Saya, D; Vogel, Z; Zippel, R | 1 |
| Lasoń, W; Machelska, H; Przewłocka, B | 1 |
| Archer, S; Glick, SD; Maisonneuve, IM | 1 |
| Butelman, ER; DeCosta, BR; Walker, EA; Woods, JH | 1 |
| Grudt, TJ; Williams, JT | 1 |
| al-Dokhayel, AA; Bloom, SR; Gilbey, SG; Lambert, PD; Wilding, JP | 1 |
| Funada, M; Misawa, M; Nagase, H; Narita, M; Suzuki, T | 1 |
| Lookingland, KJ; Manzanares, J; Moore, KE; Wagner, EJ | 2 |
| de Costa, BR; Orlowski, M; Petrov, ES; Rice, KC; Robinson, SR; Smotherman, WP; Varlinskaya, EI | 1 |
| Dickenson, AH; Stanfa, LC | 1 |
| Guirimand, F; Le Bars, D; Strimbu-Gozariu, M; Willer, JC | 1 |
| Chavkin, C; Terman, GW; Wagner, JJ | 2 |
| Isaac, L; Ristic, H | 1 |
| Buéno, L; Gué, M; Junien, JL | 1 |
| Kishioka, S; Masuda, Y; Miyamoto, Y; Ozaki, M; Yamamoto, H | 1 |
| Benoliel, JJ; Bourgoin, S; Cesselin, F; Collin, E; Hamon, M; Mauborgne, A | 1 |
| Cui, Y; Lee, T; Wang, LC | 1 |
| Chen, C; DeRiel, JK; Kunapuli, S; Liu-Chen, LY; Xue, JC; Yu, L; Zhu, J | 1 |
| Boersma, CJ; Pool, CW; Van Heerikhuize, JJ; Van Leeuwen, FW | 1 |
| Brune, K; Geisslinger, G; Schmidt, N | 1 |
| Compton, DR; Martin, BR; Mechoulam, R; Razdan, RK; Smith, PB; Welch, SP | 1 |
| Iwamoto, Y; Kamei, J; Kasuya, Y; Misawa, M; Nagase, H | 2 |
| Ho, IK; Hoskins, B; Jaw, SP; Makimura, M; Oh, KW | 1 |
| Dassaud, M; Diop, L; Junien, JL; Pascaud, X; Rivière, PJ | 1 |
| Callahan, P; Janik, J; Klosterman, S; Parman, R | 1 |
| Cai, YP; Yu, LC | 2 |
| al-Dokhayel, AA; Bloom, SR; Bohuon, C; Comoy, E; Gilbey, SG; Lambert, PD; Wilding, JP | 1 |
| Dewey, WL; Smith, FL | 1 |
| Itoh, J; Kameyama, T; Ukai, M | 2 |
| Bidlack, JM; Lawrence, DM | 1 |
| Adloff, M; Angel, F; Chamouard, P; Klein, A; Martin, E | 1 |
| Ahmed, MS; Cemerikic, B; Zamah, R | 2 |
| Billington, CJ; Grace, MK; Kotz, CM; Levine, AS | 1 |
| Maier, SF; Mooney-Heiberger, K; Watkins, LR; Wiertelak, EP; Yang, HY | 1 |
| Iwamoto, Y; Kamei, J; Kasuya, Y; Misawa, M; Mizuno, D; Nagase, H; Okutomi, T; Soma, G; Suzuki, T | 1 |
| Martin, BR; Smith, PB; Welch, SP | 1 |
| Bodnar, RJ; Hahn, B; Koch, JE; Ruegg, H | 1 |
| Lendvai, B; Sándor, A; Sándor, NT | 1 |
| Kavaliers, M; Saucier, DM | 1 |
| Carr, KD; Papadouka, V | 2 |
| Farouz-Grant, F; Lin, CE; Portoghese, PS; Takemori, AE | 1 |
| Kaneto, H; Takahashi, M; Tokuyama, S | 1 |
| Colwell, DD; Kavaliers, M | 1 |
| Ellis, EF; Embrey, JP; Uphouse, LA; Ward, CR; Welch, SP | 1 |
| Mulder, AH; Ronken, E; Schoffelmeer, AN | 1 |
| Kapusta, DR; Obih, JC | 1 |
| Ai, Y; Butelman, ER; de Costa, BR; Negus, SS; Woods, JH | 1 |
| Grubb, BD; Schaible, HG; Stiller, RU | 1 |
| Innes, DG; Kavaliers, M | 1 |
| Holtzman, SG; Paronis, CA; Waddell, AB | 1 |
| Lin, CE; Portoghese, PS; Takemori, AE | 1 |
| Dewey, WL; Dombrowski, DS; Smith, FL; Welch, SP | 1 |
| Dosaka-Akita, K; Holaday, JW; Long, JB; Tortella, FC | 1 |
| Moody, CA; Robinson, SR; Smotherman, WP; Spear, LP | 1 |
| Barg, J; Belcheva, MM; Coscia, CJ; Rowiński, J | 1 |
| Chiappinelli, VA; Fletcher, GH | 1 |
| De Sarro, A; De Sarro, G; Masuda, Y; Sinopoli, S; Trimarchi, GR | 1 |
| Bull, PM; Clarke, G; Douglas, AJ; MacMillan, SJ; McGrory, BG; Neumann, I; Russell, JA; Way, SA; Wright, DM | 1 |
| Amico, MC; Morrone, LA; Romanelli, L; Valeri, P | 1 |
| Welch, SP | 2 |
| Bourgoin, S; Cesselin, F; Collin, E; Frechilla, D; Hamon, M; Le Bars, D; Pohl, M | 1 |
| Henriksen, SJ; Koob, GF; Mattox, A; Negus, SS; Pasternak, GW; Portoghese, PS; Takemori, AE; Weinger, MB | 1 |
| Shippenberg, TS; Spanagel, R | 1 |
| Bonavera, JJ; Kalra, PS; Kalra, SP | 1 |
| Andres-Trelles, F; Baamonde, A; Hidalgo, A; Menendez, L | 1 |
| Funada, M; Misawa, M; Nagase, H; Narita, M; Suzuki, T; Takahashi, Y; Takamori, K | 1 |
| Portoghese, PS; Takemori, AE | 1 |
| Alcaraz, C; Milanés, MV; Vargas, ML | 1 |
| Beczkowska, IW; Bodnar, RJ; Bostock, ME; Koch, JE; Leibowitz, SF | 1 |
| Kest, B; Liebeskind, JC; Mogil, JS; Sadowski, B; Sternberg, WF | 1 |
| Callahan, P; Janik, J; Kehoe, L; Parman, R | 1 |
| Gidener, S; LePard, KJ; Stephens, RL | 1 |
| Faltus, RE; Inman, JD; Laferrière, A; Moss, IR | 1 |
| Hong, X; Li, B; Li, M | 1 |
| Bodnar, RJ; Cooper, ML; Glass, MJ; Ragnauth, A | 1 |
| Heidbreder, C; LeFevour, A; Shippenberg, TS | 1 |
| Bofetiado, DM; D'Alecy, LG; Mayfield, KP | 1 |
| Hong, X; Li, M; Yang, Y | 1 |
| Fuentes, JA; Reche, I; Ruiz-Gayo, M | 2 |
| Brooks, DP; Rossi, NF | 1 |
| Dawson-Basoa, ME; Gintzler, AR | 2 |
| Barton, C; Bray, GA; York, DA | 1 |
| Grouhel, A; Wettstein, JG | 1 |
| Misawa, M; Nagase, H; Suzuki, T; Tsuda, M | 1 |
| Kavaliers, M; Perrot-Sinal, TS | 1 |
| Butour, JL; Meunier, JC; Moisand, C; Mollereau, C; Parmentier, M | 1 |
| Feng, J; Kendig, JJ | 1 |
| Durham, RA; Johnson, JD; Lookingland, KJ; Moore, KE | 1 |
| Kameyama, T; Kobayashi, T; Shan-Wu, X; Ukai, M | 1 |
| Hubbard, JI | 1 |
| Duncan, MJ; Elde, RP; Gurwell, JA; Hauser, KF; Maderspach, K; Stiene-Martin, A | 1 |
| Chen, SF; Ghanta, VK; Hiramoto, RN; Hsueh, CM; Huang, HJ | 1 |
| Feuerstein, TJ; Gleichauf, O; Jackisch, R; Landwehrmeyer, GB; Peckys, D; Scheremet, R | 1 |
| Hiramatsu, M; Hyodo, T; Kameyama, T | 1 |
| Catheline, G; Guilbaud, G; Kayser, V | 2 |
| Kovacević-Jovanović, V; Mancev, Z; Pesić, G; Radulović, J; Stanojević, S; Vasiljević, T | 1 |
| Hiramatsu, M; Kameyama, T; Nabeshima, T; Sasaki, M | 1 |
| Chen, HS; Hu, DY; Liu, LM; Lu, RQ; Yan, W | 1 |
| Hong, JS; Hudson, PM; Jin, L; Kong, LY; McMillian, MK | 1 |
| Berger, SP; Broderick, PA; Hsu, K; Reid, MS; Souza, KH | 1 |
| Gent, JP; Goodchild, CS; Guo, Z; Musgreave, A | 1 |
| Adler, MW; Geller, EB; Ghosh, S | 1 |
| Angel, F; Chevalier, E; Dahl, SG; Friese, N; Junien, JL; Pascaud, X; Riviere, PJ | 1 |
| Itoh, J; Kameyama, T; Kobayashi, T; Shinkai, N; Ukai, M | 1 |
| Laorden, ML; Llobel, F | 1 |
| Gross, RA; MacDonald, RL; Moises, HC; Wiley, JW | 1 |
| Flumerfelt, BA; Newman, DD; Rajakumar, N; Stoessl, AJ | 1 |
| Bombelli, R; Cosentino, M; Ferrari, M; Frigo, G; Giaroni, C; Lecchini, S; Marino, F; Rasini, E | 1 |
| Ho, IK; Hoshi, K; Ma, T; Oh, S | 1 |
| Goldstein, BD; Zachariou, V | 1 |
| Glick, SD; Maisonneuve, IM; Pearl, SM | 1 |
| Barg, J; Eilam, Y; Ela, C; Hasin, Y; Vogel, Z | 1 |
| Bartosz-Bechowski, H; Davis, P; Hruby, VJ; Kramer, TH; Porreca, F | 1 |
| Lishmanov, YB; Maslov, LN; Smagin, GN; Ugdyzhekova, DS | 1 |
| Lin, CE; Mello, NK; Negus, SS; Portoghese, PS | 1 |
| Misawa, M; Mori, T; Nagase, H; Suzuki, T; Tsuji, M | 1 |
| Lishmanov, IB; Maslov, LN; Ugdyzhekova, DS | 1 |
| Barton, C; Bray, GA; Ookuma, K; York, DA | 2 |
| Chapman, I; Hope, PJ; Horowitz, M; Morley, JE; Wittert, GA | 1 |
| Burke, TF; Garner, HR; Lawhorn, CD; Stoner, JM; Wessinger, WD | 1 |
| Bertolucci, M; De Simoni, MG; Perego, C | 1 |
| Dahl, SG; Diop, L; Friese, N; Lambert, C; Rivière, PJ | 1 |
| Feng, Y; Ho, IK; Rockhold, RW | 1 |
| Bodnar, RJ; Ragnauth, A; Ruegg, H | 1 |
| Gallo, RV; Smith, MJ | 1 |
| Childers, SR; Sim, LJ | 1 |
| Lysle, DT; Perez, L | 1 |
| Higashiyama, K; Kamei, J; Kubo, H; Li, J; Nagase, H; Ohmiya, S; Ohsawa, M; Takahashi, H; Xiao, P | 1 |
| Bicknell, RJ; Dye, S; Leng, G | 1 |
| McGinty, JF; Rawls, SM | 1 |
| Wong, TM; Zhang, WM | 1 |
| He, Z; Ho, IK; Tsang, BK; Wongchanapai, W | 1 |
| Li, HY; Wang, HX; Wong, TM; Yu, XC | 1 |
| Hao, JX; Xu, XJ; Yu, W | 1 |
| Gross, GJ; Hsu, AK; Schultz, JE | 1 |
| Fábián, G; Offermanns, S; Rottmann, M; Spicher, K; Szücs, M | 1 |
| Miller, RJ; Simen, AA | 1 |
| Butelman, ER; Ko, MC; Mosberg, HI; Sobczyk-Kojiro, K; Van Bemmel, B; Woods, JH; Zernig, G | 1 |
| Dar, MS | 1 |
| Aimi, N; Matsumoto, K; Sakai, S; Takayama, H; Thongpradichote, S; Tohda, M; Watanabe, H | 1 |
| Bellgowan, PS; Helmstetter, FJ | 1 |
| Fujimoto, JM; Holmes, BB; Rady, JJ | 1 |
| Georgieva, J; Nylander, I; Ogren, SO; Sandin, J; Schött, PA; Terenius, L | 1 |
| Dawson-Basoa, M; Gintzler, AR | 1 |
| Hansson, P; Löfgren, O; Lundeberg, T; Theodorsson, E; Yu, LC | 1 |
| Ingenito, AJ; Zhai, QZ | 1 |
| Gu, Y; Huang, LY; Lai, SL | 1 |
| Agmo, A; Belzung, C | 1 |
| Matsuzawa, S; Misawa, M; Nagase, H; Suzuki, T | 2 |
| Chao, CC; Gekker, G; Hu, S; Kravitz, F; Peterson, PK | 1 |
| Xie, CW; Yu, TP | 1 |
| Hata, F; Nishio, H; Nishiwaki, H; Saitoh, N; Takeuchi, T | 1 |
| Choleris, E; Colwell, DD; Kavaliers, M | 1 |
| Andoh, T; Ito, H; Kamiya, Y; Oka, K; Watanabe, I | 1 |
| Bian, JS; Wong, TM; Xia, Q; Zhang, WM | 1 |
| Brown, CH; Leng, G; Ludwig, M | 2 |
| Foxx-Orenstein, AE; Grider, JR; Jin, JG | 1 |
| Kameyama, T; Shinkai, N; Ukai, M | 1 |
| Gerrits, MA; Kuzmin, AV; Van Ree, JM | 1 |
| Hjorth, SA; Jones, RM; Portoghese, PS; Schwartz, TW | 1 |
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| Castor, MGME; Duarte, IDG; Guzzo, LS; Klein, A; Petrocchi, JA; Romero, TRL; Soares Santos, RR | 1 |
| Erikson, CM; Walker, BM; Wei, G | 1 |
| Chai, JR; Dong, H; Huang, X; Liu, GY; Long, JD; Ma, Y; Wang, YH; Wang, YJ; Xiao, ZC; Xu, XJ; Ye, RF; Zan, GY | 1 |
| Jastrzebska, K; Przewlocki, R; Rodriguez Parkitna, J; Sikora, M; Skupio, U | 1 |
| Anderson, RI; Becker, HC; Bloodgood, DW; Boyt, KM; Griffin, WC; Haun, HL; Kash, TL; Lopez, MF; Pati, D | 1 |
| Hein, M; Ji, G; Navratilova, E; Neugebauer, V; Phelps, C; Porreca, F; Qu, C; Yakhnitsa, V | 1 |
| Katsuyama, S; Komatsu, T; Kubota, A; Morinaga, O; Ogawa, K; Okamura, T; Sakurada, C; Sakurada, T; Tabata, K; Takano, F; Tsuzuki, M | 1 |
| Cui, Y; Fan, R; Feng, N; Fu, F; Gu, X; Guo, H; Jia, M; Li, J; Liu, Y; Pei, J; Wang, Y; Yang, L; Zhang, F; Zhang, S | 1 |
| Heller, NM; Maher, DP; Walia, D | 1 |
| Bannister, K; Dickenson, AH; Navratilova, E; Phelps, CE; Porreca, F | 1 |
| Kreek, MJ; Zhou, Y | 1 |
| Grace, PM; Hutchinson, MR; Kwilasz, AJ; Metcalf, MD; Peng, Y; Portoghese, PS; Rice, KC; Selfridge, BR; Wang, X; Wang, Y; Watkins, LR; Wu, S; Zhang, T; Zhang, X | 1 |
| Almada, RC; Calvo, F; Coimbra, NC; da Silva Soares, R; da Silva, JA; de Paiva, YB; Medeiros, P; Roncon, CM | 1 |
| Capim, SL; Côrtes, WDS; Gonçalves, GM; Laureano-Melo, R; Marinho, BG; Oliveira, PA; Vasconcellos, MLAA | 1 |
| Freeman, KB; Huskinson, SL; Naylor, JE; Prisinzano, TE; Townsend, EA; Zamarripa, CA | 1 |
| Fan, R; Feng, N; Fu, F; Guo, H; Li, J; Liu, Y; Liu, Z; Pei, J; Wang, K; Zhang, F; Zhang, S; Zhao, M | 1 |
| Bassani da Silva, B; Fernandes Magalhães, S; Gonçalves Dos Santos, G; Parada, CA; Tambeli, CH; Vendramini, PH; Vieira, WF | 1 |
| Agirregoitia, E; Agirregoitia, N; Olabarrieta, E; Romero-Aguirregomezcorta, J; Totorikaguena, L | 1 |
| Chen, Q; He, W; Ivanova, D; Kuang, Y; Lass, G; Li, X; Liu, Y; Long, H; Lyu, Q; O'Byrne, KT; Wang, L; Wang, Y; Yu, S | 1 |
| Maslov, LN; Naryzhnaya, NV; Nesterov, EA; Prokudina, ES; Tsibulnikov, SY | 1 |
| Akins, NS; Chen, F; Grothusen, J; Hossain, MI; Huang, J; Ji, J; Le, HV; Lin, W; Liu, R; Wang, S; Xi, J; Xu, J; Zhou, Y | 1 |
| Bahr, BA; Bogyo, M; Ding, S; Etchegaray, JI; Gan, L; Le, D; Li, Y; Liu, K; Sayed, FA; Telpoukhovskaia, MA; Xie, M; Zhan, L; Zhou, Y | 1 |
| Chavkin, C; Land, BB; Newton, KA; Reichard, KL; Rivera, ZMG; Schattauer, SS; Sotero de Menezes, PM | 1 |
| D'Ângelo, MQ; Ferreira, AJ; Maltos, KLM; Pacheco, CMDF; Queiroz-Junior, CM; Soares, RV | 1 |
| Baamonde, A; González-Rodríguez, S; Lastra, A; Machelska, H; Menéndez, L; Seitz, V; Stein, C | 1 |
| Townsend, EA | 1 |
| Kim, SA; Kim, YJ; Lee, GJ; Oh, SB | 1 |
| Cowan, A; Dun, NJ; Inan, S | 1 |
| Araya, EI; Baggio, DF; Barroso, AR; Chichorro, JG; Koren, LO; Turnes, JM; Zanoveli, JM | 1 |
| Berg, KA; Chavera, TS; Clarke, WP; Jamshidi, RJ; Jennings, EM; Smith, HR; Wedemeyer, MJ | 1 |
3 review(s) available for naltrexone and norbinaltorphimine
| Article | Year |
|---|---|
2002 Medicinal Chemistry Division Award address: monoamine transporters and opioid receptors. Targets for addiction therapy.
Topics: Animals; Biogenic Monoamines; Biological Transport; Carrier Proteins; Cocaine; Fluorescent Dyes; Humans; Isoquinolines; Ligands; Morphinans; Narcotic Antagonists; Piperidines; Protein Binding; Radioisotopes; Receptors, Opioid; Structure-Activity Relationship; Substance-Related Disorders | 2003 |
Interactions between kappa opioid agonists and cocaine. Preclinical studies.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Psychological; Discrimination Learning; Humans; Naloxone; Naltrexone; Receptors, Opioid, kappa; Self Administration | 2000 |
Targeting Itch with Ligands Selective for κ Opioid Receptors.
Topics: Animals; Dynorphins; Guanidines; Humans; Ligands; Mice; Morphinans; Naltrexone; p-Methoxy-N-methylphenethylamine; Peptide Fragments; Pruritus; Receptors, Opioid, kappa; Spiro Compounds | 2015 |
847 other study(ies) available for naltrexone and norbinaltorphimine
| Article | Year |
|---|---|
O3-(2-carbomethoxyallyl) ethers of opioid ligands derived from oxymorphone, naltrexone, etorphine, diprenorphine, norbinaltorphimine, and naltrindole. Unexpected O3-dealkylation in the opioid radioligand displacement assay.
Topics: Alkylation; Animals; Brain; Diprenorphine; Drug Stability; Ethers; Etorphine; Guinea Pigs; Indoles; Methacrylates; Molecular Structure; Morphinans; Naltrexone; Narcotic Antagonists; Narcotics; Oxymorphone; Phenols; Radioligand Assay; Receptors, Opioid; Tritium | 1992 |
Binaltorphimine-related bivalent ligands and their kappa opioid receptor antagonist selectivity.
Topics: Animals; Chemical Phenomena; Chemistry; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Male; Mice; Models, Molecular; Morphine; Muscle, Smooth; Naltrexone; Receptors, Opioid; Receptors, Opioid, kappa; Structure-Activity Relationship | 1988 |
Only one pharmacophore is required for the kappa opioid antagonist selectivity of norbinaltorphimine.
Topics: Animals; Chemical Phenomena; Chemistry; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Ileum; Male; Mice; Morphine; Naltrexone; Receptors, Opioid; Receptors, Opioid, kappa; Stereoisomerism; Structure-Activity Relationship; Vas Deferens | 1988 |
kappa-Opioid receptor in humans: cDNA and genomic cloning, chromosomal assignment, functional expression, pharmacology, and expression pattern in the central nervous system.
Topics: Adenylyl Cyclases; Aged; Amino Acid Sequence; Base Sequence; Central Nervous System; Chromosome Mapping; Chromosomes, Human, Pair 8; Cloning, Molecular; DNA, Complementary; Exons; Genomic Library; Humans; In Situ Hybridization; Ligands; Middle Aged; Molecular Sequence Data; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Proteins; RNA, Messenger; Sequence Homology, Amino Acid; Signal Transduction; Tissue Distribution | 1995 |
Cloning and functional comparison of kappa and delta opioid receptors from mouse brain.
Topics: Amino Acid Sequence; Animals; Base Sequence; Brain Chemistry; Cloning, Molecular; In Situ Hybridization; Mice; Molecular Sequence Data; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Somatostatin; RNA, Messenger; Sequence Homology, Amino Acid; Substrate Specificity; Tissue Distribution | 1993 |
Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications.
Topics: Animals; Aorta, Thoracic; Cocaine; Cyclic AMP; Electric Stimulation; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Mice; Muscle, Smooth; Opioid-Related Disorders; Rats; Receptors, Dopamine; Receptors, Opioid; Receptors, Serotonin; Substance-Related Disorders | 1998 |
Identification of an opioid kappa receptor subtype-selective N-substituent for (+)-(3R,4R)-dimethyl-4-(3-hydroxyphenyl)piperidine.
Topics: Animals; Binding, Competitive; Drug Evaluation, Preclinical; Guinea Pigs; In Vitro Techniques; Lactones; Ligands; Narcotic Antagonists; Piperidines; Putamen; Radioligand Assay; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship | 1998 |
Investigation of the selectivity of oxymorphone- and naltrexone-derived ligands via site-directed mutagenesis of opioid receptors: exploring the "address" recognition locus.
Topics: Amino Acid Sequence; Base Sequence; Binding, Competitive; Cell Line; Humans; Ligands; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Naltrexone; Narcotic Antagonists; Oxymorphone; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2001 |
14-amino, 14-alkylamino, and 14-acylamino analogs of oxymorphindole. Differential effects on opioid receptor binding and functional profiles.
Topics: Analgesics, Opioid; Animals; Binding, Competitive; CHO Cells; Cricetinae; Morpholines; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, mu; Structure-Activity Relationship | 2003 |
Identification of a new scaffold for opioid receptor antagonism based on the 2-amino-1,1-dimethyl-7-hydroxytetralin pharmacophore.
Topics: Binding Sites; Models, Molecular; Narcotic Antagonists; Piperidines; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship; Tetrahydronaphthalenes | 2004 |
N-substituted cis-4a-(3-hydroxyphenyl)-8a-methyloctahydroisoquinolines are opioid receptor pure antagonists.
Topics: Animals; Benzeneacetamides; CHO Cells; Cricetinae; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Isoquinolines; Models, Molecular; Molecular Conformation; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2005 |
Naloxone acts as a potent analgesic in transgenic mouse models of sickle cell anemia.
Topics: Analgesics; Analgesics, Opioid; Anemia, Sickle Cell; Animals; Chemokine CCL5; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Drug Synergism; Injections, Intraventricular; Injections, Spinal; Injections, Subcutaneous; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Knockout; Mice, Transgenic; Morphine; Naloxone; Pain; Pain Measurement; Receptors, CCR5 | 2007 |
Flavonoids as opioid receptor ligands: identification and preliminary structure-activity relationships.
Topics: Flavonoids; Humans; Hypericum; Ligands; Narcotic Antagonists; Plants, Medicinal; Receptors, Opioid; Receptors, Opioid, kappa; Structure-Activity Relationship | 2007 |
Syntheses and opioid receptor binding properties of carboxamido-substituted opioids.
Topics: Amides; Analgesics, Opioid; Humans; Protein Binding; Receptors, Opioid; Structure-Activity Relationship; Tramadol | 2009 |
Synthesis and pharmacological evaluation of 6-naltrexamine analogs for alcohol cessation.
Topics: Alcohol Deterrents; Alcoholism; Animals; Humans; Liver; Male; Mice; Naltrexone; Nociceptin Receptor; Protein Binding; Rats; Rats, Wistar; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship | 2009 |
Generation of novel radiolabeled opiates through site-selective iodination.
Topics: Animals; Binding Sites; Binding, Competitive; CHO Cells; Cricetinae; Cricetulus; Humans; Iodine Radioisotopes; Molecular Structure; Neurotransmitter Agents; Oxymorphone; Radioligand Assay; Receptors, Opioid | 2011 |
Opioid δ₁ receptor antagonist 7-benzylidenenaltrexone as an effective resistance reverser for chloroquine-resistant Plasmodium chabaudi.
Topics: Antimalarials; Benzylidene Compounds; Chloroquine; Drug Resistance; Molecular Structure; Naltrexone; Parasitic Sensitivity Tests; Plasmodium chabaudi; Receptors, Opioid, mu; Stereoisomerism; Structure-Activity Relationship | 2011 |
Pyrrolo- and pyridomorphinans: non-selective opioid antagonists and delta opioid agonists/mu opioid partial agonists.
Topics: Analgesics, Opioid; Animals; CHO Cells; Cricetinae; Cricetulus; Humans; Kinetics; Morphinans; Protein Binding; Pyridines; Pyrroles; Receptors, Opioid, delta; Receptors, Opioid, mu; Structure-Activity Relationship | 2014 |
Novel fluoroalkyl derivatives of selective kappa opioid receptor antagonist JDTic: Design, synthesis, pharmacology and molecular modeling studies.
Topics: Dose-Response Relationship, Drug; Drug Design; Humans; Hydrocarbons, Fluorinated; Models, Molecular; Molecular Structure; Receptors, Opioid, kappa; Structure-Activity Relationship; Tetrahydroisoquinolines | 2015 |
Antitrichomonal activity of δ opioid receptor antagonists, 7-benzylidenenaltrexone derivatives.
Topics: Animals; Antitrichomonal Agents; Benzylidene Compounds; CHO Cells; Cricetulus; Dose-Response Relationship, Drug; Molecular Structure; Naltrexone; Receptors, Opioid, delta; Structure-Activity Relationship; Trichomonas vaginalis | 2017 |
Kappa-/mu-receptor interactions in the opioid control of the in vivo release of substance P-like material from the rat spinal cord.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Kinetics; Male; Models, Neurological; Naloxone; Naltrexone; Pyrrolidines; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord; Substance P | 1992 |
Extremely long-lasting antagonistic actions of nor-binaltorphimine (nor-BNI) in the mouse tail-flick test.
Topics: Age Factors; Animals; Benzeneacetamides; Benzomorphans; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Time Factors | 1992 |
A highly selective kappa-opioid receptor agonist, CI-977, reduces excitatory synaptic potentials in the rat locus coeruleus in vitro.
Topics: Amino Acids; Analgesics; Animals; Benzofurans; Benzomorphans; Bicuculline; Depression, Chemical; Electric Stimulation; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; In Vitro Techniques; Ligands; Locus Coeruleus; Membrane Potentials; Naloxone; Naltrexone; Picrotoxin; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Synapses | 1992 |
Effects of selective opioid receptor agonists and antagonists during myocardial ischaemia.
Topics: Animals; Arrhythmias, Cardiac; Coronary Disease; Coronary Vessels; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Hemodynamics; Male; Morphinans; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1992 |
The electrophysiological effects of opioid receptor-selective antagonists on sheep Purkinje fibres.
Topics: Acidosis; Action Potentials; Animals; Coronary Disease; Hyperkalemia; Hypoxia; Morphinans; Naltrexone; Narcotic Antagonists; Purkinje Fibers; Sheep | 1992 |
Maintenance of acute morphine tolerance in mice by selective blockage of kappa opioid receptors with norbinaltorphimine.
Topics: Animals; Drug Tolerance; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Receptors, Opioid, kappa; Spinal Cord | 1992 |
The mu-opioid activity of kappa-opioid receptor agonist compounds in the guinea pig ileum.
Topics: Animals; Ethylketocyclazocine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Nalorphine; Naltrexone; Phenazocine; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1992 |
Sexual differences in kappa opioid receptor-mediated regulation of tuberoinfundibular dopaminergic neurons.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Arcuate Nucleus of Hypothalamus; Dihydroxyphenylalanine; Dopamine; Female; Male; Median Eminence; Naltrexone; Narcotic Antagonists; Neurons; Orchiectomy; Ovariectomy; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Sex Characteristics; Tuber Cinereum | 1992 |
Peripheral analgesic activities of peptides related to alpha-melanocyte stimulating hormone and interleukin-1 beta 193-195.
Topics: alpha-MSH; Amino Acid Sequence; Analgesics; Animals; Dinoprostone; Endotoxins; Escherichia coli; Interleukin-1; Male; Molecular Sequence Data; Naltrexone; Peptides; Peripheral Nerves; Rats; Rats, Wistar; Receptors, Opioid, kappa | 1992 |
The effect of blockade of kappa-opioid receptors in the medial basal hypothalamus and medial preoptic area on luteinizing hormone release during midpregnancy in the rat.
Topics: Animals; Female; Hypothalamus, Middle; Luteinizing Hormone; Naltrexone; Perfusion; Pregnancy; Pregnancy, Animal; Preoptic Area; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa | 1992 |
Long term kappa-opioid receptor blockade following nor-binaltorphimine.
Topics: Analgesics; Animals; Male; Naltrexone; Pain Measurement; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid, kappa | 1992 |
The stimulation of central kappa opioid receptors decreases male sexual behavior and locomotor activity.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Behavior, Animal; Body Temperature; Injections; Male; Motor Activity; Naloxone; Naltrexone; Nucleus Accumbens; Preoptic Area; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, kappa; Sexual Behavior, Animal; Tegmentum Mesencephali | 1992 |
On the mechanism of the interaction of ketamine and halothane in vitro.
Topics: Animals; Drug Interactions; GTP-Binding Proteins; Guinea Pigs; Halothane; Ileum; In Vitro Techniques; Ketamine; Muscle, Smooth; Muscle, Smooth, Vascular; Myenteric Plexus; Naloxone; Naltrexone; Pertussis Toxin; Receptors, Opioid; Virulence Factors, Bordetella | 1992 |
Effects of naltrindole and nor-binaltorphimine treatment on antinociception induced by sub-acute selective mu opioid receptor blockade.
Topics: Animals; Indoles; Male; Morphinans; Naltrexone; Pain; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sensitivity and Specificity | 1992 |
Kappa-opioids decrease excitatory transmission in the dentate gyrus of the guinea pig hippocampus.
Topics: Action Potentials; Animals; Benzeneacetamides; Diprenorphine; Dynorphins; Electrophysiology; Endorphins; Guinea Pigs; Hippocampus; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Synapses | 1992 |
Opposing tonically active endogenous opioid systems modulate the mesolimbic dopaminergic pathway.
Topics: Analgesics; Animals; Benzeneacetamides; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Infusions, Parenteral; Limbic System; Male; Microinjections; Models, Neurological; Naltrexone; Nucleus Accumbens; Pyrrolidines; Rats; Rats, Inbred Strains; Somatostatin; Tegmentum Mesencephali | 1992 |
Naloxone and norbinaltorphimine administered intracerebroventricularly antagonize spinal morphine-induced antinociception in mice through the antianalgesic action of spinal dynorphin A (1-17).
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Dynorphins; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Naltrexone | 1992 |
Endopeptidase 24.15 inhibition and opioid antinociception.
Topics: Amino Acid Sequence; Analgesics; Animals; Dynorphins; Enkephalin, Methionine; Male; Metalloendopeptidases; Molecular Sequence Data; Naltrexone; Narcotics; Pain Measurement; Protease Inhibitors; Rats; Rats, Inbred Strains; Reaction Time | 1992 |
Centrally mediated cardiovascular actions of dynorphin A(1-8) on rat hippocampal formation.
Topics: Animals; Blood Pressure; Dynorphins; Heart Rate; Hippocampus; Injections, Intraventricular; Lidocaine; Male; Naltrexone; Peptide Fragments; Rats; Rats, Inbred Strains; Respiration | 1992 |
Modulation of acute morphine tolerance by corticotropin-releasing factor and dynorphin A in the mouse spinal cord.
Topics: Animals; Corticotropin-Releasing Hormone; Drug Tolerance; Dynorphins; Injections, Spinal; Male; Mice; Morphine; Naltrexone; Peptide Fragments; Spinal Cord | 1992 |
Activation of kappa-opioid receptors depresses electrically evoked excitatory postsynaptic potentials on 5-HT-sensitive neurones in the rat dorsal raphé nucleus in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Afferent Pathways; Animals; Benzofurans; Bicuculline; Bombesin; Cholecystokinin; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Evoked Potentials; Glutamates; Glutamic Acid; In Vitro Techniques; Kynurenic Acid; N-Methylaspartate; Naloxone; Naltrexone; Neurons; Picrotoxin; Prazosin; Pyrrolidines; Quinoxalines; Raphe Nuclei; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Serotonin; Synapses; Tetrodotoxin | 1992 |
Pharmacological profiles of fentanyl analogs at mu, delta and kappa opiate receptors.
Topics: Analgesics, Opioid; Animals; Benzeneacetamides; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fentanyl; Guinea Pigs; Ileum; Male; Mice; Naltrexone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vas Deferens | 1992 |
Kappa opioid receptor activity modulates memory for peck-avoidance training in the 2-day-old chick.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Animals, Newborn; Avoidance Learning; Chickens; Dose-Response Relationship, Drug; Dynorphins; Male; Memory; Naltrexone; Peptide Fragments; Pyrrolidines; Receptors, Opioid, kappa | 1992 |
Effects of the opiates on the paraventricular nucleus in genetically polydipsic mice.
Topics: Animals; Dynorphins; Female; In Vitro Techniques; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Microinjections; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Neurons; Paraventricular Hypothalamic Nucleus; Quaternary Ammonium Compounds; Synapses; Thirst | 1992 |
N-methyl-D-aspartate (NMDA) and opioid receptors mediate dynorphin-induced spinal cord injury: behavioral and histological studies.
Topics: Animals; Dextrorphan; Dynorphins; Glial Fibrillary Acidic Protein; Immunohistochemistry; Infusions, Parenteral; Male; Motor Activity; N-Methylaspartate; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Serotonin; Silver Staining; Spinal Cord; Staining and Labeling | 1992 |
Identification of a novel receptor mediating substance P-induced behavior in the mouse.
Topics: Analysis of Variance; Animals; Behavior, Animal; Binding Sites; Indoles; Injections, Spinal; Male; Mice; Morphinans; Naloxone; Naltrexone; Peptide Fragments; Substance P | 1992 |
Effects of nor-binaltorphimine on the development of analgesic tolerance to and physical dependence on morphine.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics; Analysis of Variance; Animals; Behavior, Animal; Body Weight; Drug Tolerance; Male; Mice; Morphine; Morphine Dependence; Naltrexone; Pyrrolidines; Rats | 1992 |
Analgesic and aversive effects of naloxone in BALB/c mice.
Topics: Analgesia; Animals; Choice Behavior; Dose-Response Relationship, Drug; Formaldehyde; Mice; Mice, Inbred BALB C; Naloxone; Naltrexone; Pain | 1992 |
Pentazocine-induced biphasic analgesia in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics; Animals; Drug Administration Schedule; Drug Interactions; Drug Tolerance; Indoles; Injections, Intraventricular; Male; Mice; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Pentazocine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Time Factors | 1991 |
Differential effects of selective mu-, kappa- and delta-opioid antagonists on electroshock seizure threshold in mice.
Topics: Animals; Anticonvulsants; Bicuculline; Dose-Response Relationship, Drug; Electroshock; gamma-Aminobutyric Acid; Indoles; Male; Mice; Mice, Inbred Strains; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Phenytoin; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1991 |
Endogenous opioids tonically inhibit the depressor neurones in the caudal ventrolateral medulla of rabbits: mediation through delta- and kappa-receptors.
Topics: Amino Acid Sequence; Animals; Endorphins; Enkephalin, Leucine; Hemodynamics; Male; Medulla Oblongata; Molecular Sequence Data; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Rabbits; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa | 1991 |
Kappa-opioid antagonist strongly attenuates drinking of genetically polydipsic mice.
Topics: Animals; Drinking Behavior; Feeding Behavior; Genetics, Behavioral; Injections, Intraventricular; Injections, Subcutaneous; Mice; Mice, Mutant Strains; Naltrexone; Narcotic Antagonists; Receptors, Opioid, kappa | 1991 |
Ontogeny of mu- and kappa-opiate receptor control of the hypothalamo-pituitary-adrenal axis in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenal Glands; Adrenocorticotropic Hormone; Animals; Corticosterone; Dexamethasone; Female; Hypothalamus; Kinetics; Morphine; Naltrexone; Pituitary Gland; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1991 |
Effects of parabrachial opioid antagonism on stimulation-induced feeding.
Topics: Animals; Electric Stimulation; Feeding Behavior; Hypothalamus; Infusions, Parenteral; Male; Microinjections; Naloxone; Naltrexone; Pons; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reference Values | 1991 |
Opioids regulate the release of human chorionic gonadotropin hormone from trophoblast tissue.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Benzeneacetamides; Chorionic Gonadotropin; Endorphins; Female; Humans; Morphine; Naltrexone; Placenta; Pregnancy; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Trophoblasts | 1991 |
Footshock- and psychological-stress prevent the development of tolerance to spinal but not supraspinal morphine.
Topics: Animals; Drug Administration Routes; Drug Tolerance; Electroshock; Injections, Intraventricular; Injections, Spinal; Injections, Subcutaneous; Male; Mice; Mice, Inbred Strains; Morphine; Naltrexone; Receptors, Opioid; Stress, Psychological | 1991 |
Opioid receptor activity of GI 87084B, a novel ultra-short acting analgesic, in isolated tissues.
Topics: Alkylation; Animals; Enkephalin, Leucine; Guinea Pigs; Ileum; Kinetics; Male; Mice; Mice, Inbred Strains; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists; Piperidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Remifentanil; Vas Deferens | 1991 |
Ingestive behavior following central [D-Ala2, Leu5, Cys6]-enkephalin (DALCE), a short-acting agonist and long-acting antagonist at the delta opioid receptor.
Topics: Animals; Deoxyglucose; Diet; Dietary Fats; Dose-Response Relationship, Drug; Enkephalin, Leucine-2-Alanine; Feeding Behavior; Food Deprivation; Glucose; Injections, Intraventricular; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid, delta | 1991 |
Role of spinal kappa opioid receptors in the blockade of the development of antinociceptive tolerance to morphine.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Drug Tolerance; Injections, Intraventricular; Injections, Spinal; Injections, Subcutaneous; Male; Mice; Morphine; Naltrexone; Nociceptors; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Spinal Cord | 1991 |
Inhibition of suckling-induced prolactin release by mu- and kappa-opioid antagonists.
Topics: Animals; Depression, Chemical; Dose-Response Relationship, Drug; Female; Injections, Intraventricular; Lactation; Luteinizing Hormone; Naloxone; Naltrexone; Narcotic Antagonists; Prolactin; Rats; Rats, Inbred Strains; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1991 |
Spinal kappa receptor-mediated analgesia of E-2078, a systemically active dynorphin analog, in mice.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Dynorphins; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Peptide Fragments; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1991 |
Hippocampal mu-receptors mediate opioid reinforcement in the CA3 region.
Topics: Animals; Dynorphins; Enkephalin, Leucine; Hippocampus; Kinetics; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pyramidal Tracts; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Reference Values; Reinforcement, Psychology; Self Administration | 1991 |
U-50,488H inhibits dynorphin and glutamate release from guinea pig hippocampal mossy fiber terminals.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Calcium; Dynorphins; Enkephalin, Leucine; Glutamates; Guinea Pigs; Hippocampus; Kinetics; Naloxone; Naltrexone; Narcotic Antagonists; Nerve Endings; Potassium Chloride; Pyrrolidines; Synaptosomes | 1991 |
Intrathecal administration of dynorphin A and its fragments increase heart rate and arterial pressure in the urethane anesthetized rat: mediation by a nonopioid mechanism.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Anesthesia, General; Animals; Antihypertensive Agents; Blood Pressure; Diastole; Dynorphins; Heart Rate; Hexamethonium; Hexamethonium Compounds; Injections, Intravenous; Injections, Spinal; Male; Naloxone; Naltrexone; Peptide Fragments; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Reference Values; Systole | 1991 |
Voltage-clamp experiments reveal receptor type-dependent modulation of chloride secretion in the guinea pig colonic mucosa by intestinal opioids.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Alprostadil; Amiloride; Amino Acid Sequence; Analgesics; Animals; Benzeneacetamides; Chlorides; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Gluconates; Guinea Pigs; Intestinal Mucosa; Male; Membrane Potentials; Molecular Sequence Data; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin; Tetrodotoxin; Theophylline | 1991 |
Activation of tuberohypophysial dopamine neurons following intracerebroventricular administration of the selective kappa opioid receptor antagonist NOR-binaltorphimine.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Hydrazines; Injections, Intraperitoneal; Male; Naltrexone; Narcotic Antagonists; Neurons; Nucleus Accumbens; Pituitary Gland; Pituitary Gland, Posterior; Rats; Receptors, Opioid, kappa | 1991 |
Antagonism of morphine antinociception by intrathecally administered corticotropin-releasing factor in mice.
Topics: Analgesia; Animals; Corticotropin-Releasing Hormone; Dose-Response Relationship, Drug; Injections, Spinal; Male; Mice; Morphine; Naltrexone; Receptors, Opioid; Receptors, Opioid, kappa | 1991 |
Role of the spacer in conferring kappa opioid receptor selectivity to bivalent ligands related to norbinaltorphimine.
Topics: Animals; Binding, Competitive; In Vitro Techniques; Indicators and Reagents; Kinetics; Ligands; Male; Molecular Conformation; Molecular Structure; Muscle Contraction; Muscle, Smooth; Naltrexone; Receptors, Opioid; Receptors, Opioid, kappa; Structure-Activity Relationship | 1991 |
Effects of selective opiate antagonists on morphine-induced hyperalgesia in domestic fowl.
Topics: Analgesia; Animals; Chickens; Dose-Response Relationship, Drug; Hot Temperature; Indoles; Injections, Intraventricular; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Respiration | 1991 |
The opioid receptor selectivity for trimebutine in isolated tissues experiments and receptor binding studies.
Topics: Animals; Drug Tolerance; Guinea Pigs; Ileum; Male; Mice; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Rabbits; Receptors, Opioid; Trimebutine; Vas Deferens | 1990 |
Reduction by central beta-funaltrexamine of food intake in rats under freely-feeding, deprivation and glucoprivic conditions.
Topics: Animals; Corpus Striatum; Dietary Carbohydrates; Dose-Response Relationship, Drug; Feeding Behavior; Food Deprivation; Glucose; Hypothalamus; Injections, Intraventricular; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Time Factors | 1990 |
Suppression of nocturnal, palatable and glucoprivic intake in rats by the kappa opioid antagonist, nor-binaltorphamine.
Topics: Animals; Brain; Circadian Rhythm; Dose-Response Relationship, Drug; Feeding Behavior; Male; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Reference Values | 1990 |
Nor-binaltorphimine decreases deprivation and opioid-induced feeding.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Feeding Behavior; Food Deprivation; Male; Naltrexone; Oligopeptides; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Reference Values | 1990 |
The anticonvulsant action of CI-977, a selective kappa-opioid receptor agonist: a possible involvement of the glycine/NMDA receptor complex.
Topics: Animals; Anticonvulsants; Benzofurans; Dizocilpine Maleate; In Vitro Techniques; Mice; Mice, Inbred Strains; Naltrexone; Piperazines; Pyrrolidines; Radioligand Assay; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Receptors, Opioid, kappa; Seizures; Stereoisomerism | 1990 |
Opioid and nonopioid mechanisms may contribute to dynorphin's pathophysiological actions in spinal cord injury.
Topics: Animals; Dynorphins; Injections, Spinal; Male; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Spinal Cord Injuries | 1990 |
Clonidine, administered intracerebroventricularly in mice, produces an anti-analgesic effect which may be mediated spinally by dynorphin A (1-17).
Topics: Analgesics; Animals; Clonidine; Dynorphins; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Reaction Time | 1990 |
Kappa opiate receptors inhibit release of oxytocin from the magnocellular system during dehydration.
Topics: Animals; Benzomorphans; Dehydration; Dynorphins; Endorphins; Hypertonic Solutions; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Osmolar Concentration; Oxytocin; Peptide Fragments; Pituitary Gland, Posterior; Protein Precursors; Radioimmunoassay; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Vasopressins | 1990 |
Reflex peristalsis in the guinea pig isolated ileum is endogenously controlled by kappa opioid receptors.
Topics: Animals; Dose-Response Relationship, Drug; Enkephalin, Leucine; Gastrointestinal Motility; Guinea Pigs; Ileum; Male; Naloxone; Naltrexone; Narcotic Antagonists; Peristalsis; Receptors, Opioid; Receptors, Opioid, kappa; Reflex; Somatostatin | 1990 |
Dynorphin A-(1-17) induces alterations in free fatty acids, excitatory amino acids, and motor function through an opiate-receptor-mediated mechanism.
Topics: Amino Acids; Animals; Dose-Response Relationship, Drug; Drosophila Proteins; Dynorphins; Fatty Acids, Nonesterified; Injections, Spinal; Male; Membrane Proteins; Motor Activity; Naltrexone; Nerve Tissue Proteins; Peptide Fragments; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Spinal Cord; Spinal Cord Injuries; Stereoisomerism | 1990 |
Effect of nor-binaltorphimine on the behavior of mice and rats receiving multiple injections of U-50,488.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Behavior, Animal; Hypothermia; Male; Mice; Mice, Inbred ICR; Naltrexone; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Yawning | 1990 |
Supraspinal analgesic action of pentazocine in mice.
Topics: Analgesics; Animals; Drug Tolerance; Indoles; Injections, Intraventricular; Male; Mice; Morphinans; Naltrexone; Pain Measurement; Pentazocine; Receptors, Opioid; Time Factors | 1990 |
Effects of chronic treatment with specific antagonists on analgesia and physical dependence on morphine in rats.
Topics: Analgesics; Animals; Indoles; Male; Morphinans; Morphine Dependence; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Weight Loss | 1990 |
Nor-binaltorphimine is a reversible, noncompetitive opioid antagonist in the mouse vas deferens with high affinity for kappa receptors in monkey brain membranes.
Topics: Animals; Cerebral Cortex; In Vitro Techniques; Macaca mulatta; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, kappa; Synaptosomes; Vas Deferens | 1990 |
Isolation of kappa opioid receptor with an aminoethyl-nor-binaltorphimine (AE-norBNI) affinity column.
Topics: Animals; Binding, Competitive; Brain Chemistry; Chromatography, Affinity; Diprenorphine; Guinea Pigs; Kinetics; Naltrexone; Receptors, Opioid; Receptors, Opioid, kappa | 1990 |
Selectivity profile of nor-binaltorphimine and ICI-197,067 in guinea pig brain.
Topics: Animals; Binding Sites; Brain; Guinea Pigs; In Vitro Techniques; Kinetics; Naltrexone; Narcotics; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1990 |
Mediation of nitrous oxide analgesia in mice by spinal and supraspinal kappa-opioid receptors.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Naltrexone; Nitrous Oxide; Pain Measurement; Receptors, Opioid; Receptors, Opioid, kappa; Spinal Cord | 1990 |
Opioid receptor-mediated inhibition of dopamine and acetylcholine release from slices of rat nucleus accumbens, olfactory tubercle and frontal cortex.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetylcholine; Animals; Benzomorphans; Cerebral Cortex; Corpus Striatum; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ergolines; In Vitro Techniques; Male; Naloxone; Naltrexone; Nucleus Accumbens; Olfactory Bulb; Oxymetazoline; Pyrrolidines; Quinpirole; Rats; Rats, Inbred Strains; Receptors, Opioid; Septal Nuclei | 1990 |
"Paradoxical" analgesia and aggravated morphine dependence induced by opioid antagonists.
Topics: Animals; Body Weight; Indoles; Male; Morphinans; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome; Substance-Related Disorders | 1990 |
Antitussive effects of two specific kappa-opioid agonists, U-50,488H and U-62,066E, in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Antitussive Agents; Cisterna Magna; Cough; Injections; Ketanserin; Male; Methysergide; Morphine; Naloxone; Naltrexone; Pyrrolidines; Rats; Rats, Inbred Strains; Reflex | 1990 |
Centrally administered opioid antagonists, nor-binaltorphimine, 16-methyl cyprenorphine and MR2266, suppress intake of a sweet solution.
Topics: Animals; Benzomorphans; Drinking Behavior; Female; Glucose; Injections, Intraventricular; Morphinans; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Saccharin | 1990 |
Selective kappa antagonist properties of nor-binaltorphimine in the rat MES seizure model.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Anticonvulsants; Electroshock; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Naltrexone; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Seizures | 1989 |
Effects of the selective kappa opioid antagonist, nor-binaltorphimine, on electrically-elicited feeding in the rat.
Topics: Animals; Brain; Eating; Electric Stimulation; Hypothalamus; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pons; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa | 1989 |
Role of central opiate receptor subtypes in the circulatory responses of awake rabbits to graded caval occlusions.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Blood Circulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Hemodynamics; Hemorrhage; Naloxone; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rabbits; Receptors, Opioid; Vena Cava, Inferior | 1989 |
Evidence that the aversive effects of opioid antagonists and kappa-agonists are centrally mediated.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Brain; Conditioning, Operant; Enkephalin, Leucine; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Somatostatin | 1989 |
Role of mu and kappa opioid receptors in conditional fear-induced analgesia: the antagonistic actions of nor-binaltorphimine and the cyclic somatostatin octapeptide, Cys2Tyr3Orn5Pen7-amide.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Behavior, Animal; Fear; Female; Formaldehyde; Naltrexone; Pain; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin | 1989 |
Intracerebroventricular physostigmine-induced analgesia: enhancement by naloxone, beta-funaltrexamine and nor-binaltorphimine and antagonism by dynorphin A (1-17).
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Dynorphins; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Narcotic Antagonists; Physostigmine; Time Factors | 1989 |
Norbinaltorphimine: antagonist profile at kappa opioid receptors.
Topics: Animals; Cricetinae; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Naltrexone; Nociceptors; Rabbits; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vas Deferens | 1987 |
Nor-binaltorphimine, a highly selective kappa-opioid antagonist in analgesic and receptor binding assays.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Guinea Pigs; Male; Mice; Morphine; Naltrexone; Oligopeptides; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa | 1988 |
Kappa receptor regulation of dopamine release from striatum and cortex of rats and guinea pigs.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cerebral Cortex; Corpus Striatum; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Male; Naltrexone; Potassium; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa | 1988 |
Suppression by nor-binaltorphimine of kappa opioid-mediated diuresis in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Diuresis; Dose-Response Relationship, Drug; Male; Morphine; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa | 1988 |
Spinal kappa-opiate receptor involvement in the analgesia of pregnancy: effects of intrathecal nor-binaltorphimine, a kappa-selective antagonist.
Topics: Analgesia; Animals; Female; Injections, Spinal; Naltrexone; Pregnancy; Pregnancy, Animal; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Sensory Thresholds; Spinal Cord | 1988 |
A brief study of the selectivity of norbinaltorphimine, (-)-cyclofoxy, and (+)-cyclofoxy among opioid receptor subtypes in vitro.
Topics: Animals; Binding, Competitive; Brain; Guinea Pigs; Isomerism; Kinetics; Membranes; Naltrexone; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship | 1988 |
Binaltorphimine and nor-binaltorphimine, potent and selective kappa-opioid receptor antagonists.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Chemical Phenomena; Chemistry; Cyclazocine; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Male; Mice; Morphine; Naloxone; Naltrexone; Pyrrolidines; Rabbits; Receptors, Opioid; Receptors, Opioid, kappa | 1987 |
Kappa-selective opiate antagonist nor-binaltorphimine improves outcome after traumatic spinal cord injury in rats.
Topics: Animals; Injections, Spinal; Male; Naltrexone; Psychomotor Performance; Rats; Rats, Inbred Strains; Spinal Cord Injuries | 1987 |
Characterization of the opioid receptor subtypes mediating the negative inotropic effects of DAMGO, DPDPE and U-50, 488H in isolated human right atria strips.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adult; Aged; Analgesics; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Heart Atria; Humans; Male; Middle Aged; Myocardial Contraction; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pyrrolidines; Receptors, Opioid | 1995 |
Tonic modulation of neurotransmitter release in the guinea-pig myenteric plexus: effect of mu and kappa opioid receptor blockade and of chronic sympathetic denervation.
Topics: Acetylcholine; Animals; Colon; Dose-Response Relationship, Drug; Guinea Pigs; Morphinans; Myenteric Plexus; Naltrexone; Narcotic Antagonists; Neurotransmitter Agents; Norepinephrine; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sympathetic Nervous System | 1995 |
Spinal delta 2-, but not delta 1-, mu-, or kappa-opioid receptors are involved in the tail-flick inhibition induced by beta-endorphin from nucleus raphe obscurus in the pentobarbital-anesthetized rat.
Topics: Amino Acid Sequence; Analgesia; Animals; Benzylidene Compounds; beta-Endorphin; Dose-Response Relationship, Drug; Enkephalin, Methionine; Injections, Intraventricular; Injections, Spinal; Male; Molecular Sequence Data; Naltrexone; Narcotic Antagonists; Pentobarbital; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin; Spinal Cord; Tail | 1995 |
The in vitro pharmacological characterization of naloxone benzoylhydrazone.
Topics: Animals; Benzeneacetamides; Binding, Competitive; Computer Simulation; Cyclohexanes; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle, Smooth; Myenteric Plexus; Naloxone; Naltrexone; Narcotic Antagonists; Pyrrolidines; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1995 |
Antinociceptive effect of a kappa-opioid receptor agonist that minimally crosses the blood-brain barrier (ICI 204448) in a rat model of mononeuropathy.
Topics: Analgesia; Analysis of Variance; Animals; Behavior, Animal; Blood-Brain Barrier; Disease Models, Animal; Drug Interactions; Hindlimb; Male; Naltrexone; Narcotic Antagonists; Nerve Compression Syndromes; Pain Threshold; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Sciatic Nerve; Vocalization, Animal | 1995 |
Opioid mu- and kappa-receptor mediate phospholipase C activation through Gi1 in Xenopus oocytes.
Topics: Animals; Benzeneacetamides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Enzyme Activation; Female; GTP-Binding Proteins; Naltrexone; Oocytes; Pyrrolidines; Receptors, Opioid, kappa; Receptors, Opioid, mu; Type C Phospholipases; Xenopus laevis | 1995 |
Effects of dynorphin A-(1-13) on carbon monoxide-induced delayed amnesia in mice studied in a step-down type passive avoidance task.
Topics: Amnesia; Animals; Avoidance Learning; Carbon Monoxide; Dynorphins; Male; Memory; Mice; Mice, Inbred Strains; Naltrexone; Peptide Fragments; Reaction Time; Receptors, Opioid, kappa; Retention, Psychology | 1995 |
Involvement of delta 1-opioid receptors in the antinociceptive effects of mexiletine in mice.
Topics: Animals; Diabetic Neuropathies; Male; Mexiletine; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Pain; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reference Values | 1995 |
Opioids and nitric oxide contribute to hypoxia-induced pial arterial vasodilation in newborn pigs.
Topics: Amino Acid Oxidoreductases; Analysis of Variance; Animals; Animals, Newborn; Arginine; Arterioles; Cerebral Arteries; Cyclic GMP; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Female; Hypoxia; Male; Muscle, Smooth, Vascular; Naltrexone; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Nitroprusside; Receptors, Opioid, kappa; Receptors, Opioid, mu; Swine; Vasodilation | 1995 |
Ca2+ channel inhibition by kappa opioid receptors expressed in Xenopus oocytes.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Barium; Calcium Channels; Electric Conductivity; GTP-Binding Proteins; Injections; Naltrexone; Oocytes; Pertussis Toxin; Pyrrolidines; Rats; Receptors, Opioid, kappa; RNA; Virulence Factors, Bordetella; Xenopus laevis | 1994 |
The opioid peptide dynorphin directly blocks NMDA receptor channels in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Dynorphins; In Vitro Techniques; Ion Channels; Naloxone; Naltrexone; Neurons; Patch-Clamp Techniques; Pyrrolidines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa; Structure-Activity Relationship; Trigeminal Nerve | 1995 |
Analysis of selective binding epitopes for the kappa-opioid receptor antagonist nor-binaltorphimine.
Topics: Amino Acid Sequence; Animals; Epitopes; Glutamine; Molecular Sequence Data; Naltrexone; Rats; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Fusion Proteins | 1995 |
Kappa opioid inhibition of morphine and cocaine self-administration in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Cocaine; Dose-Response Relationship, Drug; Extinction, Psychological; Female; Morphine; Naltrexone; Narcotics; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reinforcement, Psychology; Self Administration | 1995 |
Functional implications of kappa opioid receptor-mediated modulation of glutamate transmission in the output regions of the basal ganglia in rodent and primate models of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Anti-Arrhythmia Agents; Basal Ganglia; Benzofurans; Callithrix; Female; Glutamic Acid; In Vitro Techniques; Male; Motor Activity; Naltrexone; Parkinson Disease, Secondary; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reserpine; Synaptic Transmission | 1995 |
Effects of kappa-opioid receptor agonists on stimulated phosphoinositide hydrolysis in rat kidney.
Topics: Animals; Carbachol; Ethylketocyclazocine; Hydrolysis; In Vitro Techniques; Kidney Cortex; Male; Naltrexone; Norepinephrine; Phosphatidylinositols; Rats; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stimulation, Chemical | 1995 |
Electrophysiological demonstration and activation of mu-opioid receptors in the rabbit sinoatrial node.
Topics: Action Potentials; Animals; Enkephalin, Leucine; Fentanyl; Microelectrodes; Naltrexone; Narcotic Antagonists; Narcotics; Patch-Clamp Techniques; Rabbits; Receptors, Opioid, mu; Sinoatrial Node | 1995 |
Selective actions of central mu and kappa opioid antagonists upon sucrose intake in sham-fed rats.
Topics: Animals; Cerebral Ventricles; Eating; Enkephalin, Leucine-2-Alanine; Infusions, Parenteral; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sucrose | 1995 |
Comparative study of the analgesic and paralytic effects induced by intrathecal dynorphin a in rats.
Topics: Analgesics; Animals; Dynorphins; Injections, Spinal; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Pain Threshold; Paralysis; Psychomotor Performance; Rats; Rats, Wistar; Reaction Time; Spinal Cord; Vocalization, Animal | 1995 |
L-type calcium channels mediate dynorphin neuropeptide release from dendrites but not axons of hippocampal granule cells.
Topics: Animals; Axons; Calcium Channel Blockers; Calcium Channels; Dendrites; Dynorphins; Guinea Pigs; Hippocampus; Isradipine; Long-Term Potentiation; Naltrexone; Nifedipine; omega-Conotoxin GVIA; Peptides; Receptors, Opioid, kappa | 1995 |
Blockade of the antinociceptive activity of centrally administered ketorolac by nor-binaltorphimine.
Topics: Analgesia; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Benzoquinones; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, Leucine; Injections, Intraventricular; Ketorolac Tromethamine; Male; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tolmetin; Tromethamine | 1995 |
Mouse strain differences in in vivo and in vitro immunosuppressive effects of opioids.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Erythrocytes; Female; Immunosuppressive Agents; Mice; Mice, Inbred Strains; Morphine; Naloxone; Naltrexone; Opioid Peptides; Pyrrolidines; Species Specificity; Spleen | 1995 |
Norbinaltorphimine protection against N-methyl-D-aspartic acid-induced convulsions and mortality.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Bicuculline; Binding, Competitive; Brain; Ibotenic Acid; Injections, Intraventricular; Kainic Acid; Male; Mice; N-Methylaspartate; Naltrexone; Receptors, N-Methyl-D-Aspartate; Seizures | 1993 |
Analysis of central opioid receptor subtype antagonism of hypotonic and hypertonic saline intake in water-deprived rats.
Topics: Animals; Enkephalin, Leucine-2-Alanine; Hypotonic Solutions; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Saline Solution, Hypertonic; Water Deprivation | 1995 |
Involvement of kappa-opioid receptor mechanisms in the calcitonin-induced potentiation of opioid effects at the hypothalamus-pituitary-adrenocortical axis.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Calcitonin; Corticosterone; Drug Synergism; Hypothalamo-Hypophyseal System; Male; Morphine; Naltrexone; Narcotics; Pituitary-Adrenal System; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1994 |
Peripheral kappa-opioid receptors mediate the antinociceptive effect of fedotozine (correction of fetodozine) on the duodenal pain reflex inrat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzyl Compounds; Blood Pressure; Dose-Response Relationship, Drug; Duodenum; Injections, Intravenous; Injections, Intraventricular; Male; Morphine; Naloxone; Naltrexone; Pain; Propylamines; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reflex | 1994 |
Kappa-opioid receptors couple to inwardly rectifying potassium channels when coexpressed by Xenopus oocytes.
Topics: Amino Acid Sequence; Animals; Base Sequence; Benzeneacetamides; Binding Sites; Cloning, Molecular; Electrophysiology; Female; GTP-Binding Proteins; Ion Channel Gating; Molecular Sequence Data; Naltrexone; Oocytes; Potassium Channels; Pyrrolidines; Rats; Receptors, Opioid, kappa; RNA, Complementary; Xenopus | 1995 |
Opioid effects on spinal [3H]5-hydroxytryptamine release are not related to their antinociceptive action.
Topics: Amino Acid Sequence; Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Isotope Labeling; Male; Molecular Sequence Data; Naltrexone; Narcotics; Potassium; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Serotonin; Somatostatin; Spinal Cord; Synaptic Transmission; Synaptosomes | 1995 |
kappa-Opioid receptor activates an inwardly rectifying K+ channel by a G protein-linked mechanism: coexpression in Xenopus oocytes.
Topics: Animals; Benzeneacetamides; Cloning, Molecular; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Gene Expression; GTP-Binding Proteins; In Vitro Techniques; Mice; Naloxone; Naltrexone; Oocytes; Pertussis Toxin; Potassium Channels; Pyrrolidines; Receptors, Opioid, kappa; RNA, Complementary; Virulence Factors, Bordetella; Xenopus | 1995 |
Long-term exposure to opioid antagonists up-regulates prodynorphin gene expression in rat brain.
Topics: Animals; Brain; Enkephalins; Gene Expression; Male; Naloxone; Naltrexone; Narcotic Antagonists; Protein Precursors; Rats; Rats, Sprague-Dawley; Time Factors | 1995 |
Endogenous opioids regulate long-term potentiation of synaptic inhibition in the dentate gyrus of rat hippocampus.
Topics: 2-Amino-5-phosphonovalerate; Animals; Bicuculline; Electric Stimulation; GABA-A Receptor Antagonists; Hippocampus; Homeostasis; In Vitro Techniques; Long-Term Potentiation; Male; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Opioid Peptides; Patch-Clamp Techniques; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Synapses; Time Factors | 1995 |
Unexpected prosecretory action component of loperamide at mu-opioid receptors in the guinea-pig colonic mucosa in vitro.
Topics: Alprostadil; Amino Acid Sequence; Animals; Chlorides; Colon; Dose-Response Relationship, Drug; Ethylketocyclazocine; Guinea Pigs; Intestinal Mucosa; Loperamide; Male; Molecular Sequence Data; Naloxone; Naltrexone; Patch-Clamp Techniques; Receptors, Opioid, delta; Receptors, Opioid, mu; Somatostatin; Theophylline | 1995 |
Antinociceptive effect of dihydroetorphine in diabetic mice.
Topics: Analgesia; Analgesics, Opioid; Animals; Binding, Competitive; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Etorphine; Injections, Intraperitoneal; Injections, Intraventricular; Injections, Subcutaneous; Male; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Receptors, Opioid, delta; Receptors, Opioid, mu | 1995 |
Kappa opioid receptor agonists suppress absence seizures in WAG/Rij rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Sequence; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electroencephalography; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Epilepsy, Absence; Injections, Intraventricular; Injections, Subcutaneous; Male; Molecular Sequence Data; Naltrexone; Pyrroles; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid, kappa; Receptors, Opioid, mu; Thiophenes | 1995 |
mu-, delta- and kappa-opiate receptors mediate antinociception in the rat tail flick test following noxious thermal stimulation of one hindpaw.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Hindlimb; Hot Temperature; Male; Naltrexone; Narcotic Antagonists; Oligopeptides; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, Opioid | 1995 |
Central opioid receptor subtype mediation of isoproterenol-induced drinking in rats.
Topics: Animals; Drinking; Enkephalin, Leucine-2-Alanine; Injections, Intraventricular; Injections, Subcutaneous; Isoproterenol; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, mu | 1994 |
Evidence that nor-binaltorphimine can function as an antagonist at multiple opioid receptor subtypes.
Topics: Amino Acid Sequence; Analgesics; Animals; Benzeneacetamides; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Injections, Intraventricular; Male; Molecular Sequence Data; Naltrexone; Narcotic Antagonists; Pain; Pain Threshold; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Somatostatin | 1994 |
Identification of kappa opioid receptors in the immune system by indirect immunofluorescence.
Topics: Acetamides; Amino Acid Sequence; Animals; Fluorescein-5-isothiocyanate; Fluorescent Antibody Technique; Immune System; Male; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Naltrexone; Receptors, Opioid, kappa; Tumor Cells, Cultured | 1995 |
Endogenous kappa-opioid systems in opiate withdrawal: role in aversion and accompanying changes in mesolimbic dopamine release.
Topics: Animals; Behavior, Animal; Biogenic Monoamines; Conditioning, Operant; Dopamine; Injections, Intraventricular; Limbic System; Male; Microdialysis; Morphine Dependence; Naloxone; Naltrexone; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reinforcement, Psychology; Substance Withdrawal Syndrome | 1994 |
Both T cells and macrophages are targets of kappa-opioid-induced immunosuppression.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Antibody Formation; Cell Separation; Cells, Cultured; Depression, Chemical; Lymphocyte Activation; Lymphocyte Cooperation; Macrophage Activation; Macrophages, Peritoneal; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Naloxone; Naltrexone; Neuroimmunomodulation; Pyrrolidines; Receptors, Opioid, kappa; Rosette Formation; Specific Pathogen-Free Organisms; T-Lymphocytes | 1994 |
Antagonism of the morphine-induced Straub tail reaction by kappa-opioid receptor activation in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Dose-Response Relationship, Drug; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Morphine; Naltrexone; Narcotic Antagonists; Pain Measurement; Pyrrolidines; Receptors, Opioid, kappa | 1993 |
Norbinaltorphimine blocks the feeding but not the reinforcing effect of lateral hypothalamic electrical stimulation.
Topics: Animals; Electric Stimulation; Feeding Behavior; Hypothalamic Area, Lateral; Injections, Intraventricular; Male; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reward; Self Stimulation | 1993 |
Differential effects of systemically administered nor-binaltorphimine (nor-BNI) on kappa-opioid agonists in the mouse writhing assay.
Topics: Animals; Dose-Response Relationship, Drug; Injections, Subcutaneous; Male; Mice; Naltrexone; Narcotic Antagonists; Pain Measurement; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1994 |
kappa-Opioid receptor-transfected cell lines: modulation of adenylyl cyclase activity following acute and chronic opioid treatments.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Animals; Benzeneacetamides; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Etorphine; GTP-Binding Proteins; Naloxone; Naltrexone; Opioid Peptides; Pertussis Toxin; Pyrrolidines; Receptors, Opioid, kappa; Virulence Factors, Bordetella | 1995 |
Kappa opioid receptor agonists inhibit the pilocarpine-induced seizures and toxicity in the mouse.
Topics: Analgesics; Animals; Benzeneacetamides; Brain; Injections, Intraperitoneal; Mice; Naltrexone; Pilocarpine; Pyrroles; Pyrrolidines; Receptors, Opioid, kappa; Seizures; Thiophenes | 1994 |
U50,488, a kappa opioid receptor agonist, attenuates cocaine-induced increases in extracellular dopamine in the nucleus accumbens of rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cocaine; Dopamine; Extracellular Space; Female; Naltrexone; Nucleus Accumbens; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa | 1994 |
Opioid thermal antinociception in rhesus monkeys: receptor mechanisms and temperature dependency.
Topics: Alfentanil; Analgesics; Animals; Azocines; Benzimidazoles; Benzomorphans; Dose-Response Relationship, Drug; Female; Hot Temperature; Macaca mulatta; Male; Nalbuphine; Naltrexone; Nociceptors; Pyrrolidines; Receptors, Opioid; Tail | 1993 |
kappa-Opioid receptors also increase potassium conductance.
Topics: Animals; Benzeneacetamides; Dynorphins; Electric Conductivity; Guinea Pigs; In Vitro Techniques; Ion Channel Gating; Male; Membrane Potentials; Naltrexone; Potassium Channels; Pyrrolidines; Receptors, Opioid, kappa; Trigeminal Nuclei | 1993 |
Inhibiting a spinal dynorphin A component enhances intrathecal morphine antinociception in mice.
Topics: Analgesics; Animals; Cerebral Ventricles; Dynorphins; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Spine | 1993 |
Dynorphin A(1-17) mediates midazolam antagonism of morphine antinociception in mice.
Topics: Analgesics; Animals; Clonidine; Dose-Response Relationship, Drug; Dynorphins; GABA Antagonists; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Midazolam; Morphine; Naloxone; Naltrexone; Pain Measurement; Reaction Time; Spinal Cord | 1993 |
The effect of central blockade of kappa-opioid receptors on neuropeptide Y-induced feeding in the rat.
Topics: Animals; Cerebral Ventricles; Drug Administration Schedule; Dynorphins; Feeding Behavior; Injections, Intraventricular; Male; Naltrexone; Neuropeptide Y; Rats; Rats, Wistar; Receptors, Opioid, kappa | 1993 |
Blockade of morphine reward through the activation of kappa-opioid receptors in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; 3,4-Dihydroxyphenylacetic Acid; Analgesics; Animals; Apomorphine; Conditioning, Operant; Dopamine; Dynorphins; Homovanillic Acid; Injections, Subcutaneous; Limbic System; Male; Mice; Mice, Inbred Strains; Morphine; Motivation; Naltrexone; Peptide Fragments; Prosencephalon; Pyrrolidines; Receptors, Opioid, kappa; Reward | 1993 |
Neurochemical evidence that estrogen-induced suppression of kappa-opioid-receptor-mediated regulation of tuberoinfundibular dopaminergic neurons is prolactin-independent.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Brain Chemistry; Dopamine; Dynorphins; Estrogens; Female; Hydrazines; Hypothalamic Hormones; Injections, Intraventricular; Median Eminence; Naltrexone; Nerve Endings; Neurons; Ovariectomy; Peptide Fragments; Prolactin; Rats; Receptors, Opioid, kappa | 1994 |
Cardiovascular effects of microinjection of dynorphin-A(1-8) into the hippocampus in conscious, spontaneously hypertensive and normotensive Wistar-Kyoto rats.
Topics: Animals; Blood Pressure; Cardiovascular System; Dose-Response Relationship, Drug; Dynorphins; Hippocampus; Hypertension; Male; Microinjections; Naltrexone; Peptide Fragments; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 1994 |
Central administration of the endopeptidase 24.15 inhibitor cFP-AAF-pAB suggests dynorphin as the endogenous ligand underlying behavioral effects of milk in the fetal rat.
Topics: Amino Acid Sequence; Animals; Behavior, Animal; Cisterna Magna; Dynorphins; Female; Fetus; Injections; Ligands; Metalloendopeptidases; Milk; Molecular Sequence Data; Naltrexone; Narcotic Antagonists; Oligopeptides; Physical Stimulation; Pregnancy; Rats; Rats, Sprague-Dawley; Somatostatin | 1994 |
Electrophysiological studies on the spinal roles of endogenous opioids in carrageenan inflammation.
Topics: Analgesics; Animals; Carrageenan; Dipeptides; Dynorphins; Electrophysiology; Endorphins; Inflammation; Injections, Spinal; Male; Microelectrodes; Naltrexone; Nerve Fibers; Neurons; Nociceptors; Rats; Rats, Sprague-Dawley; Spinal Cord; Synaptic Transmission | 1994 |
Effects of mu, delta and kappa opioid antagonists on the depression of a C-fiber reflex by intrathecal morphine and DAGO in the rat.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Spinal; Morphine; Naltrexone; Narcotic Antagonists; Nerve Fibers; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reflex; Somatostatin | 1994 |
Comparative effects of intrahippocampal injection of dynorphin A(1-8), dynorphin A(1-13), dynorphin A(1-17), U-50,488H, and dynorphin B on blood pressure and heart rate in spontaneously hypertensive and normotensive Wistar-Kyoto rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Sequence; Animals; Antihypertensive Agents; Blood Pressure; Dynorphins; Heart Rate; Hippocampus; Hypertension; Male; Molecular Sequence Data; Naltrexone; Peptide Fragments; Pyrrolidines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Reference Values | 1994 |
Cardiovascular responses to intra-hippocampal dynorphin A-(1-8) in spontaneously hypertensive rats.
Topics: Aging; Amino Acid Sequence; Animals; Blood Pressure; Dose-Response Relationship, Drug; Dynorphins; Heart Rate; Hemodynamics; Hippocampus; Male; Microinjections; Molecular Sequence Data; Naltrexone; Peptide Fragments; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; Species Specificity | 1994 |
Kappa opioids inhibit induction of long-term potentiation in the dentate gyrus of the guinea pig hippocampus.
Topics: Animals; Benzeneacetamides; Dynorphins; Electric Stimulation; Guinea Pigs; Hippocampus; Long-Term Potentiation; Male; Naloxone; Naltrexone; Pyrrolidines; Receptors, Opioid, kappa; Synaptic Transmission | 1994 |
Pharmacological characterization of dynorphin A (1-17)-induced effects on spinal cord-evoked potentials.
Topics: Animals; Drug Interactions; Dynorphins; Evoked Potentials; Ganglia, Spinal; Male; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Spinal Cord | 1994 |
The kappa agonist fedotozine modulates colonic distention-induced inhibition of gastric motility and emptying in dogs.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzyl Compounds; Bretylium Compounds; Catheterization; Colon; Dogs; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Gastric Emptying; Gastrointestinal Motility; Granisetron; Hexamethonium; Male; Naltrexone; Narcotic Antagonists; Propylamines; Pyrrolidines; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reflex; Stomach | 1994 |
Participation of opioid receptor types on post-tetanic twitch inhibition in isolated guinea-pig ileal longitudinal muscle.
Topics: Amino Acid Sequence; Animals; Dynorphins; Electric Stimulation; Enkephalin, Leucine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Molecular Sequence Data; Morphine; Muscle Contraction; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Narcotics; Peptide Fragments; Receptors, Opioid | 1994 |
Morphine reduces the release of met-enkephalin-like material from the rat spinal cord in vivo by acting at delta opioid receptors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Injections, Spinal; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pyrrolidines; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Spinal Cord | 1994 |
Species difference in the modulatory effect of kappa agonist on 5-HT release from ground squirrel and rat hippocampus.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Aging; Animals; Dose-Response Relationship, Drug; Female; Hippocampus; In Vitro Techniques; Male; Naloxone; Naltrexone; Potassium; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Sciuridae; Serotonin; Species Specificity; Tetrodotoxin | 1994 |
Differential binding domains of peptide and non-peptide ligands in the cloned rat kappa opioid receptor.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Sequence; Animals; Base Sequence; Benzeneacetamides; Binding Sites; Binding, Competitive; Cell Line; Chlorocebus aethiops; Cloning, Molecular; Diprenorphine; DNA Primers; Dynorphins; Endorphins; Kinetics; Ligands; Molecular Sequence Data; Naltrexone; Polymerase Chain Reaction; Protein Conformation; Protein Structure, Secondary; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Fusion Proteins; Transfection | 1994 |
Characterization of opioid binding sites in the neural and intermediate lobe of the rat pituitary gland by quantitative receptor autoradiography.
Topics: Amino Acid Sequence; Analgesics; Animals; Autoradiography; Benzomorphans; Binding, Competitive; Densitometry; Enkephalins; Ligands; Male; Molecular Sequence Data; Naloxone; Naltrexone; Pituitary Gland; Pituitary Gland, Posterior; Protein Precursors; Rats; Rats, Wistar; Receptors, Opioid; Receptors, Opioid, kappa | 1994 |
Opioid receptor agonist potencies of morphine and morphine-6-glucuronide in the guinea-pig ileum.
Topics: Amino Acid Sequence; Animals; Electric Stimulation; Guinea Pigs; Ileum; In Vitro Techniques; Male; Molecular Sequence Data; Morphine; Morphine Derivatives; Muscle Contraction; Muscle, Smooth; Naltrexone; Peptide Fragments; Peptides; Receptors, Opioid; Receptors, Opioid, mu; Somatostatin | 1994 |
Lack of catecholamine involvement in the increased luteinizing hormone release due to blockade of kappa-opioid receptors in the medial basal hypothalamus during midpregnancy in the rat.
Topics: Animals; Dopamine; Female; Hypothalamus, Middle; Luteinizing Hormone; Naltrexone; Norepinephrine; Perfusion; Pregnancy; Pregnancy, Animal; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Secretory Rate | 1994 |
The pharmacological activity of anandamide, a putative endogenous cannabinoid, in mice.
Topics: Analgesics; Animals; Arachidonic Acids; Binding, Competitive; Brain; Calcium Channel Blockers; Cyclohexanols; Dronabinol; Drug Administration Routes; Drug Interactions; Endocannabinoids; Male; Membranes; Mice; Mice, Inbred ICR; Naltrexone; Polyunsaturated Alkamides; Receptors, Purinergic P2; Tritium | 1994 |
Effects of diabetes on the antinociceptive effect of (+/-)pentazocine in mice.
Topics: Analgesics; Animals; Diabetes Mellitus, Experimental; Drug Synergism; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Nociceptors; Pentazocine; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1994 |
Involvement of kappa-opioid receptors in opioid dependence/withdrawal: studies using butorphanol.
Topics: Animals; Butorphanol; Injections, Intraventricular; Male; Naloxone; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Substance Withdrawal Syndrome; Substance-Related Disorders | 1994 |
Role of vagal afferents in the antinociception produced by morphine and U-50,488H in the colonic pain reflex in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Blood Pressure; Colon; Injections, Intraventricular; Injections, Spinal; Male; Morphine; Naloxone; Naltrexone; Neurons, Afferent; Pain; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reflex; Vagotomy; Vagus Nerve | 1994 |
Multiple opiate receptor subtypes are involved in the stimulation of growth hormone release by beta-endorphin in female rats.
Topics: Animals; beta-Endorphin; Diestrus; Enkephalin, Leucine; Female; Growth Hormone; Kinetics; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1994 |
Effects of opioid receptors antagonists administration to suprachiasmatic nucleus on hibernation of ground squirrels Citellus dauricus.
Topics: Animals; Endorphins; Enkephalin, Leucine; Female; Hibernation; Injections; Male; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Sciuridae; Suprachiasmatic Nucleus | 1993 |
Endogenous dynorphins inhibit excitatory neurotransmission and block LTP induction in the hippocampus.
Topics: Action Potentials; Animals; Benzeneacetamides; Dynorphins; Glutamates; Glutamic Acid; Guinea Pigs; Hippocampus; In Vitro Techniques; Naltrexone; Neural Inhibition; Neurotransmitter Agents; Pyrrolidines; Receptors, Opioid, kappa; Synapses; Time Factors | 1993 |
A role for neuropeptide-Y, dynorphin, and noradrenaline in the central control of food intake after food deprivation.
Topics: Animals; Antibodies, Monoclonal; Dynorphins; Eating; Food Deprivation; Immunization, Passive; Male; Naltrexone; Neuropeptide Y; Norepinephrine; Phentolamine; Rats; Rats, Wistar; Receptors, Opioid, kappa | 1993 |
Endogenous dynorphin modulates calcium-mediated antinociception in mice.
Topics: Animals; Calcium; Dynorphins; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Nociceptors; Peptide Fragments; Phenobarbital | 1993 |
Dynorphin A-(1-13) markedly improves scopolamine-induced impairment of spontaneous alternation performance in mice.
Topics: Analysis of Variance; Animals; Drug Interactions; Dynorphins; Male; Memory; Mice; Naltrexone; Peptide Fragments; Psychomotor Performance; Receptors, Opioid, kappa; Scopolamine | 1993 |
The kappa opioid receptor expressed on the mouse R1.1 thymoma cell line is coupled to adenylyl cyclase through a pertussis toxin-sensitive guanine nucleotide-binding regulatory protein.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Analgesics; Animals; Cell Membrane; Cyclic AMP; Dynorphins; GTP-Binding Proteins; Mice; Naltrexone; Pertussis Toxin; Pyrrolidines; Receptors, Opioid, kappa; Sensitivity and Specificity; Thymoma; Thymus Neoplasms; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1993 |
Regulatory role of enteric kappa opioid receptors in human colonic motility.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Colon, Sigmoid; Dynorphins; Electric Stimulation; Enkephalin, Leucine; Gastrointestinal Motility; Humans; In Vitro Techniques; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid, kappa | 1993 |
Opioids regulation of human chorionic gonadotropin release from trophoblast tissue is mediated by gonadotropin releasing hormone.
Topics: Chorionic Gonadotropin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Gonadotropin-Releasing Hormone; Humans; In Vitro Techniques; Naltrexone; Narcotics; Pregnancy; Receptors, Opioid, kappa; Trophoblasts | 1994 |
The effect of norbinaltorphimine, beta-funaltrexamine and naltrindole on NPY-induced feeding.
Topics: Animals; Eating; Injections, Intraventricular; Male; Naltrexone; Narcotic Antagonists; Neuropeptide Y; Rats; Rats, Sprague-Dawley | 1993 |
The nature of conditioned anti-analgesia: spinal cord opiate and anti-opiate neurochemistry.
Topics: Analgesia; Analgesics; Animals; Conditioning, Classical; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Immune Sera; Injections, Spinal; Male; Morphine; Naltrexone; Narcotic Antagonists; Oligopeptides; Proglumide; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Spinal Cord | 1994 |
Antinociceptive effect of lipopolysaccharide from Pantoea agglomerans on streptozotocin-induced diabetic mice.
Topics: Analgesics; Animals; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Enterobacter; Injections, Subcutaneous; Lipopolysaccharides; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Pain Measurement | 1994 |
Interactions between delta 9-tetrahydrocannabinol and kappa opioids in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzofurans; Dronabinol; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Mice, Inbred ICR; Naltrexone; Pyrrolidines; Receptors, Opioid, kappa | 1994 |
Differential modulation of angiotensin II and hypertonic saline-induced drinking by opioid receptor subtype antagonists in rats.
Topics: Angiotensin II; Animals; Drinking; Enkephalin, Leucine-2-Alanine; Male; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Saline Solution, Hypertonic | 1994 |
Influence of selective opiate antagonists on striatal acetylcholine and dopamine release.
Topics: Acetylcholine; Animals; Corpus Striatum; Dopamine; Electric Stimulation; In Vitro Techniques; Male; Naloxone; Naltrexone; Narcotic Antagonists; Oxidopamine; Rats; Rats, Wistar | 1993 |
The effect of selective opioid antagonists on butorphanol-induced feeding.
Topics: Animals; Butorphanol; Dose-Response Relationship, Drug; Feeding Behavior; Injections, Intraventricular; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1994 |
Antagonistic effects of the selective, competitive N-methyl-D-aspartate (NMDA) receptor antagonist, NPC 12626, on kappa opiate-induced analgesia in male deer mice.
Topics: Amino Acids; Analgesics; Animals; Benzeneacetamides; Dizocilpine Maleate; Dose-Response Relationship, Drug; Male; Morphine; Naloxone; Naltrexone; Nociceptors; Pain Measurement; Peromyscus; Pyrrolidines; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa | 1994 |
The role of multiple opioid receptors in the maintenance of stimulation-induced feeding.
Topics: Amino Acid Sequence; Animals; Differential Threshold; Dose-Response Relationship, Drug; Eating; Electric Stimulation; Hypothalamic Area, Lateral; Male; Molecular Sequence Data; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid | 1994 |
Structure-activity relationship of N17'-substituted norbinaltorphimine congeners. Role of the N17' basic group in the interaction with a putative address subsite on the kappa opioid receptor.
Topics: Animals; Binding, Competitive; Brain; Guinea Pigs; In Vitro Techniques; Male; Mice; Muscle, Smooth; Naltrexone; Receptors, Opioid, kappa; Structure-Activity Relationship | 1994 |
The role of multiple opioid receptors in the potentiation of reward by food restriction.
Topics: Animals; Behavior, Animal; Brain; Conditioning, Operant; Dose-Response Relationship, Drug; Food Deprivation; Injections, Intraventricular; Male; Naltrexone; Narcotic Antagonists; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reward; Self Stimulation | 1994 |
Antinociceptive effect of L-arginine in diabetic mice.
Topics: Analgesics; Animals; Arginine; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Endorphins; Injections, Intraventricular; Injections, Subcutaneous; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Nitroarginine; Pain Measurement; Reaction Time | 1994 |
Antinociceptive effect of dihydroetorphine and its tolerance/dependence liability in mice.
Topics: Analgesics; Animals; Body Weight; Drug Tolerance; Etorphine; Male; Mice; Mice, Inbred Strains; Morphine; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Substance-Related Disorders | 1993 |
Multiple opioid system involvement in the mediation of parasitic-infection induced analgesia.
Topics: Analgesia; Animals; Coccidiosis; Endorphins; Enkephalin, Leucine; Host-Parasite Interactions; Male; Mice; Mice, Inbred Strains; Naloxone; Naltrexone; Narcotic Antagonists | 1993 |
Antinociceptive activity of intrathecal ketorolac is blocked by the kappa-opioid receptor antagonist, nor-binaltorphimine.
Topics: Analgesics; Animals; Drug Interactions; Drug Tolerance; Injections, Spinal; Ketorolac; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Pain; Receptors, Opioid, kappa; Tolmetin | 1993 |
Interacting presynaptic kappa-opioid and GABAA receptors modulate dopamine release from rat striatal synaptosomes.
Topics: Analysis of Variance; Animals; Benzeneacetamides; Bicuculline; Corpus Striatum; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; gamma-Aminobutyric Acid; Kinetics; Male; Naltrexone; Narcotics; Oligopeptides; Picrotoxin; Potassium; Pyrrolidines; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, Opioid, kappa; Synaptosomes | 1993 |
Central kappa opioid receptor-evoked changes in renal function in conscious rats: participation of renal nerves.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Diuresis; Glomerular Filtration Rate; Heart Rate; Kidney; Male; Naltrexone; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sympathetic Nervous System | 1993 |
Kappa opioid antagonist effects of systemically administered nor-binaltorphimine in a thermal antinociception assay in rhesus monkeys.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetamides; Analgesics; Animals; Benzomorphans; Dose-Response Relationship, Drug; Female; Heating; Macaca mulatta; Naltrexone; Nociceptors; Pain Measurement; Pyrrolidines; Receptors, Opioid, kappa; Time Factors | 1993 |
Neurophysiological evidence for increased kappa opioidergic control of spinal cord neurons in rats with unilateral inflammation at the ankle.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Arthritis, Experimental; Freund's Adjuvant; Inflammation; Joints; Male; Naltrexone; Neurons; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, kappa; Reference Values; Spinal Cord; Stress, Mechanical | 1993 |
Arousal following intra-preoptic area administration of naltrexone, ICI 174864 or nor-BNI in hibernating ground squirrels.
Topics: Animals; Arousal; Brain Mapping; Dose-Response Relationship, Drug; Enkephalin, Leucine; Female; Hibernation; Male; Naltrexone; Narcotic Antagonists; Preoptic Area; Receptors, Opioid, delta; Receptors, Opioid, kappa; Sciuridae | 1993 |
Sex differences in the antinociceptive effects of the enkephalinase inhibitor, SCH 34826.
Topics: Analgesia; Analgesics; Animals; Dioxolanes; Dipeptides; Enkephalin, Leucine; Female; Male; Naloxone; Naltrexone; Narcotic Antagonists; Neprilysin; Peromyscus; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Restraint, Physical; Sex Characteristics; Stress, Psychological | 1993 |
Naltrexone in vivo protects mu receptors from inactivation by beta-funaltrexamine, but not kappa receptors from inactivation by nor-binaltorphimine.
Topics: Analgesics; Animals; Benzeneacetamides; Cisterna Magna; Dose-Response Relationship, Drug; Injections; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain Measurement; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1993 |
Synthesis and kappa-opioid antagonist selectivity of a norbinaltorphimine congener. Identification of the address moiety required for kappa-antagonist activity.
Topics: Animals; Electric Stimulation; Guinea Pigs; Mice; Muscles; Naltrexone; Narcotic Antagonists; Structure-Activity Relationship | 1993 |
The role of endogenous opioids as mediators of the hypothermic effects of intrathecally administered calcium and calcitonin gene-related peptide in mice.
Topics: Animals; Body Temperature Regulation; Calcitonin Gene-Related Peptide; Calcium; Dose-Response Relationship, Drug; Drug Interactions; Endorphins; Hypothalamus; Hypothermia, Induced; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Time Factors | 1993 |
The kappa opioid agonist U-50,488H antagonizes respiratory effects of mu opioid receptor agonists in conscious rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Morphine; Naltrexone; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Respiration | 1993 |
Effects of dopamine and kappa opioid receptors on fetal responsiveness to perioral stimuli.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzazepines; Brain; Dopamine; Dose-Response Relationship, Drug; Female; Fetal Movement; Naltrexone; Pregnancy; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Opioid, kappa; Stereotyped Behavior; Sucking Behavior | 1993 |
kappa-Opioid agonist modulation of [3H]thymidine incorporation into DNA: evidence for the involvement of pertussis toxin-sensitive G protein-coupled phosphoinositide turnover.
Topics: Alkaloids; Animals; Atropine; Autoradiography; Benzeneacetamides; Benzophenanthridines; Brain; Chlorides; DNA; Endorphins; GTP-Binding Proteins; Lithium; Lithium Chloride; Naltrexone; Pertussis Toxin; Phenanthridines; Phosphatidylinositols; Phosphoric Monoester Hydrolases; Protein Kinase C; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Virulence Factors, Bordetella | 1993 |
The actions of the kappa 1 opioid agonist U-50,488 on presynaptic nerve terminals of the chick ciliary ganglion.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Animals, Newborn; Chickens; Electrophysiology; Ganglia, Parasympathetic; In Vitro Techniques; Membrane Potentials; Naltrexone; Nerve Endings; Potassium Channels; Pyrrolidines; Receptors, Opioid, kappa; Sodium Channels; Synapses | 1993 |
Anticonvulsant effects of U-54494A and U-50488H in genetically epilepsy-prone rats and DBA/2 mice: a possible involvement of glycine/NMDA receptor complex.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Anticonvulsants; Epilepsy; Female; Male; Mice; Mice, Inbred DBA; Motor Activity; Naloxone; Naltrexone; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Opioid, kappa; Serine | 1993 |
Effects of the kappa-opioid agonist U50,488 on parturition in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Female; Infusions, Intravenous; Injections, Intravenous; Labor, Obstetric; Male; Morphine; Naloxone; Naltrexone; Oxytocin; Pregnancy; Pyrrolidines; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Opioid, kappa; Uterine Contraction | 1993 |
Withdrawal contractures of guinea-pig isolated ileum after acute activation of kappa-opioid receptors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Clonidine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Nifedipine; Pyrrolidines; Receptors, Opioid, kappa; Substance Withdrawal Syndrome | 1993 |
Blockade of cannabinoid-induced antinociception by norbinaltorphimine, but not N,N-diallyl-tyrosine-Aib-phenylalanine-leucine, ICI 174,864 or naloxone in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Dronabinol; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Infusions, Intravenous; Injections, Spinal; Mice; Naloxone; Naltrexone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta | 1993 |
Opioid control of the release of calcitonin gene-related peptide-like material from the rat spinal cord in vivo.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Calcitonin Gene-Related Peptide; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Spinal; Iodine Radioisotopes; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pyrrolidines; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1993 |
Effect of antagonists selective for mu, delta and kappa opioid receptors on the reinforcing effects of heroin in rats.
Topics: Animals; Heroin; Male; Naloxone; Naltrexone; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Self Administration | 1993 |
Modulation of morphine-induced sensitization by endogenous kappa opioid systems in the rat.
Topics: Animals; Dialysis; Dopamine; Injections, Intraventricular; Limbic System; Male; Morphine; Motor Activity; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa | 1993 |
Mode of action of interleukin-1 in suppression of pituitary LH release in castrated male rats.
Topics: Animals; Corticotropin-Releasing Hormone; Depression, Chemical; Hypothalamus; Injections, Intraventricular; Interleukin-1; Luteinizing Hormone; Male; Naloxone; Naltrexone; Narcotic Antagonists; Orchiectomy; Pituitary Gland; Rats; Receptors, Opioid | 1993 |
Involvement of spinal kappa opioid receptors in a type of footshock induced analgesia in mice.
Topics: Analgesia; Animals; Cerebral Ventricles; Electroshock; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Receptors, Opioid, kappa; Spinal Cord; Stress, Psychological | 1993 |
Effects of kappa-agonist on the antinociception and locomotor enhancing action induced by morphine in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzylamines; Dopamine; Dose-Response Relationship, Drug; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Narcotics; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sympathomimetics | 1993 |
Kappa opioid receptor-mediated regulation of prolactin and alpha-melanocyte-stimulating hormone secretion in male and female rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; alpha-MSH; Animals; Female; Male; Naltrexone; Prolactin; Pyrrolidines; Rats; Receptors, Opioid, kappa; Sex Characteristics; Sex Factors; Time Factors | 1993 |
The mixed antinociceptive agonist-antagonist activity of beta-endorphin(1-27) in mice.
Topics: Animals; Benzylidene Compounds; beta-Endorphin; Male; Mice; Naltrexone; Narcotic Antagonists; Nociceptors; Peptide Fragments; Receptors, Opioid | 1993 |
Chronic kappa opioid receptor antagonism produces supersensitivity to U-50,488H at the hypothalamo-pituitary-adrenocortical (HPA) axis level.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Body Weight; Corticosterone; Dose-Response Relationship, Drug; Hyperalgesia; Hypothalamo-Hypophyseal System; Male; Naloxone; Naltrexone; Pituitary-Adrenal System; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Sensitivity and Specificity; Sodium Chloride | 1993 |
Central opioid receptor subtype antagonists differentially reduce intake of saccharin and maltose dextrin solutions in rats.
Topics: Animals; Drinking Behavior; Enkephalin, Leucine-2-Alanine; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Polysaccharides; Rats; Rats, Sprague-Dawley; Saccharin | 1993 |
U-50,488H, a kappa-opioid receptor agonist, markedly prevents memory dysfunctions induced by transient cerebral ischemia in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amnesia; Analgesics; Animals; Avoidance Learning; Body Temperature; Drug Interactions; Ischemic Attack, Transient; Learning; Male; Memory; Mice; Mice, Inbred Strains; Naltrexone; Pyrrolidines; Receptors, Opioid, kappa; Reperfusion; Time Factors | 1993 |
Evidence for the up-regulation of kappa opiate mechanisms in mice selectively bred for high analgesia.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics; Animals; Female; Mice; Morphine; Naltrexone; Pyrrolidines; Receptors, Opioid, kappa; Stress, Psychological; Swimming; Up-Regulation | 1993 |
Opiate receptor subtype involvement in the stimulation of prolactin release by beta-endorphin in female rats.
Topics: Animals; beta-Endorphin; Diestrus; Dose-Response Relationship, Drug; Enkephalin, Leucine; Female; Lactation; Male; Naltrexone; Narcotic Antagonists; Prolactin; Rats; Rats, Sprague-Dawley; Receptors, Opioid | 1993 |
8-OH-DPAT stimulates gastric acid secretion through a vagal-independent, adrenal-mediated mechanism.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenal Glands; Adrenergic alpha-Antagonists; Animals; Dioxanes; Dopamine Antagonists; Ganglia, Sympathetic; Gastric Acid; Gastric Acidity Determination; Idazoxan; Imidazoles; Male; Naltrexone; Rats; Rats, Sprague-Dawley; Serotonin Receptor Agonists; Spiperone; Splenic Artery; Stimulation, Chemical; Vagotomy; Vagus Nerve | 1995 |
Cardiorespiratory and sleep-wake behavior in developing swine: kappa-opioid influence.
Topics: Aging; Animals; Blood Pressure; Electromyography; Heart Rate; Hemodynamics; Hypoxia; Naltrexone; Oxygen; Receptors, Opioid, kappa; Respiration; Sleep; Swine; Wakefulness | 1995 |
The role of norepinephrine in mediating luteinizing hormone release in response to blockade of kappa-opioid receptors in the medial preoptic area.
Topics: Animals; Basal Metabolism; Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; Female; Indomethacin; Luteinizing Hormone; Naltrexone; Norepinephrine; Preoptic Area; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Secretory Rate | 1995 |
[Effects of intrasubarachnoid space injection of anti dynorphin A1-13 serum or nor-BNI on the recovery of spinal cord injury in rats].
Topics: Animals; Dynorphins; Immune Sera; In Vitro Techniques; Injections, Spinal; Male; Naltrexone; Narcotic Antagonists; Peptide Fragments; Rats; Receptors, Opioid, kappa; Spinal Cord Injuries | 1995 |
General, mu and kappa opioid antagonists in the nucleus accumbens alter food intake under deprivation, glucoprivic and palatable conditions.
Topics: Animals; Evaluation Studies as Topic; Feeding Behavior; Food Deprivation; Glucose; Male; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sucrose | 1995 |
kappa-Opioid receptor agonists prevent sensitization to the conditioned rewarding effects of cocaine.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzeneacetamides; Cocaine; Conditioning, Psychological; Dopamine; Male; Naltrexone; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reward | 1996 |
Alkaloid delta agonist BW373U86 increases hypoxic tolerance.
Topics: Acute Disease; Animals; Benzamides; Body Temperature; Dose-Response Relationship, Drug; Hypoxia; Male; Mice; Mice, Inbred Strains; Naltrexone; Narcotic Antagonists; Piperazines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1996 |
[Receptor mechanism of dynorphin A in rat secondary spinal cord injuries].
Topics: Animals; Dynorphins; Immune Sera; Injections, Spinal; Male; Naltrexone; Peptide Fragments; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Spinal Cord Injuries | 1996 |
A role for central cannabinoid and opioid systems in peripheral delta 9-tetrahydrocannabinol-induced analgesia in mice.
Topics: Analgesics; Animals; Central Nervous System; Dose-Response Relationship, Drug; Dronabinol; Dynorphins; Injections, Intravenous; Male; Mice; Naltrexone; Narcotic Antagonists; Pain Measurement; Peripheral Nervous System; Piperidines; Pyrazoles; Reaction Time; Receptors, Cannabinoid; Receptors, Drug; Receptors, Opioid; Rimonabant | 1996 |
kappa-Opioid agonist inhibition of osmotically induced AVP release: preferential action at hypothalamic sites.
Topics: Animals; Arginine Vasopressin; Culture Techniques; Hypothalamus; Male; Naltrexone; Narcotic Antagonists; Osmotic Pressure; Piperidines; Pituitary Gland, Posterior; Rats; Rats, Inbred Strains; Receptors, Opioid, kappa | 1996 |
Estrogen and progesterone activate spinal kappa-opiate receptor analgesic mechanisms.
Topics: Animals; Electroshock; Estradiol; Female; Naltrexone; Narcotic Antagonists; Nociceptors; Pain Measurement; Pain Threshold; Pregnancy; Pregnancy, Animal; Progesterone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1996 |
Opioid receptor subtype control of galanin-induced feeding.
Topics: Animals; Dietary Fats; Eating; Fasting; Galanin; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin | 1996 |
Opioid antagonist profile of SC nor-binaltorphimine in the formalin paw assay.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Formaldehyde; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Pyrroles; Pyrrolidines; Receptors, Opioid, kappa; Receptors, Opioid, mu; Thiophenes | 1996 |
Involvement of the opioid system in the anxiolytic effect of diazepam in mice.
Topics: Analgesics, Non-Narcotic; Animals; Anti-Anxiety Agents; Anticonvulsants; Body Temperature; Conflict, Psychological; Diazepam; Drug Interactions; Dynorphins; Male; Mice; Mice, Inbred Strains; Motor Activity; Naltrexone; Narcotic Antagonists; Peptide Fragments; Receptors, Opioid; Receptors, Opioid, kappa | 1996 |
Pronociceptive effects of the neuropeptide, nociceptin, in the land snail, Cepaea nemoralis.
Topics: Amino Acid Sequence; Animals; Dose-Response Relationship, Drug; Dynorphins; Hot Temperature; Molecular Sequence Data; Naltrexone; Narcotic Antagonists; Nociceptin; Nociceptors; Opioid Peptides; Pain Measurement; Receptors, Opioid; Receptors, Opioid, kappa; Snails; Time Factors | 1996 |
Replacement of Gln280 by His in TM6 of the human ORL1 receptor increases affinity but reduces intrinsic activity of opioids.
Topics: Adenylyl Cyclase Inhibitors; Animals; Binding, Competitive; Cell Membrane; CHO Cells; Cricetinae; Diprenorphine; Dynorphins; Etorphine; Fentanyl; Glutamine; Histamine; Humans; Kinetics; Ligands; Naltrexone; Narcotic Antagonists; Narcotics; Nociceptin; Nociceptin Receptor; Opioid Peptides; Receptors, Opioid | 1996 |
Estrogen and progesterone activate spinal kappa-opiate receptor analgesic mechanisms.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics; Animals; Estrogens; Female; Naltrexone; Narcotic Antagonists; Nociceptors; Pain Threshold; Progesterone; Pseudopregnancy; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Spinal Cord | 1996 |
The NMDA receptor antagonist MK-801 differentially modulates mu and kappa opioid actions in spinal cord in vitro.
Topics: Analgesics; Animals; Animals, Newborn; Benzeneacetamides; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; In Vitro Techniques; Membrane Potentials; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1996 |
Evidence that D2 receptor-mediated activation of hypothalamic tuberoinfundibular dopaminergic neurons in the male rat occurs via inhibition of tonically active afferent dynorphinergic neurons.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; 3,4-Dihydroxyphenylacetic Acid; Afferent Pathways; Analgesics; Animals; Cerebral Ventricles; Dihydroxyphenylalanine; Dopa Decarboxylase; Dopamine; Dopamine Agonists; Dynorphins; Hypothalamus; Hypothalamus, Middle; Injections, Intraperitoneal; Injections, Intraventricular; Limbic System; Male; Median Eminence; Naltrexone; Narcotic Antagonists; Neurons; Nucleus Accumbens; Prolactin; Pyrrolidines; Quinolines; Rats; Receptors, Dopamine D2; Receptors, Opioid, kappa | 1996 |
Systemic administration of dynorphin A-(1-13) markedly improves cycloheximide-induced amnesia in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amnesia; Analgesics; Animals; Avoidance Learning; Cycloheximide; Dynorphins; Injections, Intraventricular; Male; Memory; Mice; Naltrexone; Narcotic Antagonists; Protein Synthesis Inhibitors; Pyrrolidines; Quaternary Ammonium Compounds; Receptors, Opioid, kappa | 1996 |
Water transport in cultured cells from the rat inner medullary collecting duct.
Topics: Animals; Arginine Vasopressin; Biological Transport; Cells, Cultured; Cyclic AMP; Dose-Response Relationship, Drug; Kidney Medulla; Kidney Tubules, Collecting; Naltrexone; Narcotic Antagonists; Osmosis; Oxytocin; Pyrrolidines; Rats; Receptors, Opioid, kappa; Water | 1996 |
kappa-opioid receptor expression defines a phenotypically distinct subpopulation of astroglia: relationship to Ca2+ mobilization, development, and the antiproliferative effect of opioids.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Astrocytes; Benzeneacetamides; Bromodeoxyuridine; Calcium; Calcium Channel Blockers; Cell Count; Cell Division; Cells, Cultured; DNA; Enzyme Inhibitors; Gene Expression Regulation, Developmental; Immunohistochemistry; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Nifedipine; Phenotype; Pyrrolidines; Receptors, Opioid, kappa; Thapsigargin; Time Factors | 1996 |
Activation of mu-opioid receptors are required for the conditioned enhancement of NK cell activity.
Topics: Animals; beta-Endorphin; Enkephalin, Leucine; Enkephalin, Methionine; Injections, Spinal; Killer Cells, Natural; Mice; Mice, Inbred BALB C; Morphinans; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu | 1996 |
Opioid receptor-mediated control of acetylcholine release in human neocortex tissue.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetylcholine; Adolescent; Adult; Aged; Analgesics; Analysis of Variance; Baclofen; Cerebral Cortex; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; GABA Agonists; Humans; Male; Middle Aged; Muscimol; Naloxone; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid, delta; Tetrodotoxin | 1996 |
Application of the message-address concept to the docking of naltrexone and selective naltrexone-derived opioid antagonists into opioid receptor models.
Topics: Amino Acid Sequence; Animals; Binding Sites; Conserved Sequence; GTP-Binding Proteins; Models, Molecular; Models, Structural; Molecular Conformation; Molecular Sequence Data; Naltrexone; Narcotic Antagonists; Protein Conformation; Receptors, Opioid, delta; Receptors, Opioid, kappa | 1996 |
U-50488H, a selective kappa-opioid receptor agonist, improves carbon monoxide-induced delayed amnesia in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amnesia; Analgesics; Animals; Avoidance Learning; Carbon Monoxide Poisoning; Electric Stimulation; Male; Mice; Naltrexone; Narcotic Antagonists; Pyrrolidines | 1996 |
Further evidence for a peripheral component in the enhanced antinociceptive effect of systemic morphine in mononeuropathic rats: involvement of kappa-, but not delta-opioid receptors.
Topics: Analgesia; Animals; Constriction; Drug Interactions; Injections, Intravenous; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Sciatic Nerve; Vocalization, Animal | 1996 |
Modulation of humoral immune response by central administration of leucine-enkephalin: effects of mu, delta and kappa opioid receptor antagonists.
Topics: Adjuvants, Immunologic; Animals; Antibody Formation; Antibody-Producing Cells; Brain; Dose-Response Relationship, Drug; Enkephalin, Leucine; Hemolytic Plaque Technique; Injections, Intraventricular; Male; Naltrexone; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1996 |
Effects of dynorphin A (1-13) on carbon monoxide-induced delayed amnesia in mice.
Topics: Amnesia; Animals; Carbon Monoxide Poisoning; Dizocilpine Maleate; Dynorphins; Excitatory Amino Acid Antagonists; Injections, Intraventricular; Male; Maze Learning; Mecamylamine; Mice; Mice, Inbred Strains; Naltrexone; Narcotic Antagonists; Narcotics; Nicotinic Antagonists; Peptide Fragments; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa | 1997 |
The importance of delta and kappa opioid receptors in the property of thyrotropin-releasing hormone against hemorrhagic shock.
Topics: Animals; Blood Pressure; Enkephalin, Leucine; Female; Heart Rate; Hemodynamics; Kinetics; Male; Naltrexone; Narcotic Antagonists; Rabbits; Receptors, Opioid, delta; Receptors, Opioid, kappa; Shock, Hemorrhagic; Thyrotropin-Releasing Hormone | 1997 |
Inhibition of lipopolysaccharide-induced nitric oxide and cytokine production by ultralow concentrations of dynorphins in mixed glia cultures.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cells, Cultured; Dynorphins; Lipopolysaccharides; Mice; Naltrexone; Neuroglia; Nitric Oxide; Peptide Fragments; Pyrrolidines; Tumor Necrosis Factor-alpha | 1997 |
Potentiation of delta 9-tetrahydrocannabinol-induced analgesia by morphine in mice: involvement of mu- and kappa-opioid receptors.
Topics: Analgesia; Analgesics, Opioid; Animals; Binding Sites; Dronabinol; Drug Synergism; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Pain Measurement; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1996 |
Neuropharmacological characterization of local ibogaine effects on dopamine release.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Dopamine; Dopamine Agents; Dose-Response Relationship, Drug; Ibogaine; Male; Microdialysis; Naloxone; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa | 1996 |
Antinociception by intrathecal midazolam involves endogenous neurotransmitters acting at spinal cord delta opioid receptors.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Midazolam; Naltrexone; Narcotic Antagonists; Nociceptors; Pain Measurement; Pain Threshold; Rats; Receptors, Opioid; Receptors, Opioid, delta; Spinal Cord | 1996 |
Interaction of cholecystokinin and somatostatin with a selective mu-opioid agonist and mu- and kappa-antagonists in thermoregulation.
Topics: Animals; Body Temperature Regulation; Cholecystokinin; Dose-Response Relationship, Drug; Endorphins; Injections, Intraventricular; Male; Naltrexone; Narcotic Antagonists; Peptide Fragments; Peptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin; Time Factors | 1997 |
Reversal by kappa-agonists of peritoneal irritation-induced ileus and visceral pain in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetic Acid; Analgesics; Animals; Benzofurans; Benzomorphans; Cyclazocine; Fentanyl; Gastric Emptying; Intestinal Pseudo-Obstruction; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Peritoneum; Pyrroles; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Thiophenes | 1997 |
Effects of the kappa-opioid dynorphin A(1-13) on learning and memory in mice.
Topics: Analgesics, Opioid; Animals; Dynorphins; Injections, Intraventricular; Learning; Learning Disabilities; Male; Memory; Memory Disorders; Memory, Short-Term; Mice; Mice, Inbred Strains; Muscarinic Antagonists; Naltrexone; Narcotic Antagonists; Peptide Fragments; Pirenzepine; Receptors, Opioid, kappa; Scopolamine | 1997 |
Effects of mu-, delta- and kappa-opioid antagonists in atrial preparations from nonfailing and failing human hearts.
Topics: Adult; Aged; Depression, Chemical; Dose-Response Relationship, Drug; Female; Heart; Heart Atria; Heart Valve Diseases; Humans; In Vitro Techniques; Male; Middle Aged; Mitral Valve; Myocardial Contraction; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1997 |
Dynorphin A-mediated reduction in multiple calcium currents involves a G(o) alpha-subtype G protein in rat primary afferent neurons.
Topics: Animals; Blotting, Western; Calcitonin Gene-Related Peptide; Calcium Channel Blockers; Calcium Channels; Dynorphins; Electric Stimulation; Ganglia, Spinal; GTP-Binding Proteins; Immunohistochemistry; Membrane Potentials; Naltrexone; Narcotic Antagonists; Neurons, Afferent; Patch-Clamp Techniques; Rats; Receptors, Opioid, kappa | 1997 |
A kappa opioid antagonist blocks sensitization in a rodent model of Parkinson's disease.
Topics: Animals; Apomorphine; Functional Laterality; Hippocampus; Infusions, Parenteral; Levodopa; Male; Motor Activity; Naltrexone; Narcotic Antagonists; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Rotation | 1997 |
Modulation of neurotransmitter release by opioid mu- and kappa-receptors from adrenergic terminals in the myenteric plexus of the guinea-pig colon: effect of alpha 2-autoreceptor blockade.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics; Animals; Colon; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Myenteric Plexus; Naloxone; Naltrexone; Narcotic Antagonists; Neurotransmitter Agents; Norepinephrine; Pyrrolidines; Receptors, Adrenergic, alpha-2; Receptors, Opioid, kappa; Receptors, Opioid, mu; Yohimbine | 1997 |
Increased release of excitatory amino acids in rat locus coeruleus in kappa-opioid agonist dependent rats precipitated by nor-binaltorphimine.
Topics: Animals; Benzeneacetamides; Butorphanol; Drug Evaluation, Preclinical; Excitatory Amino Acids; Locus Coeruleus; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Substance Withdrawal Syndrome; Substance-Related Disorders | 1997 |
Dynorphin-(1-8) inhibits the release of substance P-like immunoreactivity in the spinal cord of rats following a noxious mechanical stimulus.
Topics: Animals; Decerebrate State; Dynorphins; Hindlimb; Male; Naltrexone; Pain; Peptide Fragments; Physical Stimulation; Radioimmunoassay; Rats; Rats, Wistar; Receptors, Opioid, kappa; Spinal Cord; Substance P | 1997 |
Evidence for roles of kappa-opioid and NMDA receptors in the mechanism of action of ibogaine.
Topics: Animals; Corpus Striatum; Dopamine; Female; Ibogaine; Morphine; Motor Activity; N-Methylaspartate; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa; Self Administration; Substance-Related Disorders | 1997 |
Distinct components of morphine effects on cardiac myocytes are mediated by the kappa and delta opioid receptors.
Topics: Analgesics, Opioid; Animals; Animals, Newborn; Calcium; Cells, Cultured; Heart; Heart Ventricles; Morphine; Myocardial Contraction; Myocardium; Naltrexone; Narcotic Antagonists; Rats; Receptors, Opioid, delta; Receptors, Opioid, kappa | 1997 |
Characterization of anandamide-induced tolerance: comparison to delta 9-THC-induced interactions with dynorphinergic systems.
Topics: Analgesics; Animals; Arachidonic Acids; Cannabinoids; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Drug Tolerance; Dynorphins; Endocannabinoids; Injections, Intraperitoneal; Injections, Spinal; Mice; Naltrexone; Narcotic Antagonists; Pain Measurement; Polyunsaturated Alkamides; Receptors, Cannabinoid; Receptors, Drug | 1997 |
Extraordinary potency of a novel delta opioid receptor agonist is due in part to increased efficacy.
Topics: Animals; Biological Assay; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Narcotic Antagonists; Peptides; Peptides, Cyclic; Receptors, Opioid, delta; Vas Deferens | 1997 |
Participation of central kappa-opioid receptor in arrhythmogenesis.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Arrhythmias, Cardiac; Dynorphins; Epinephrine; Hexamethonium; Male; Naloxone; Naltrexone; Narcotic Antagonists; Peptide Fragments; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, kappa | 1997 |
Effects of kappa opioids on cocaine self-administration by rhesus monkeys.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Circadian Rhythm; Cocaine; Dose-Response Relationship, Drug; Ethylketocyclazocine; Female; Macaca mulatta; Male; Naloxone; Naltrexone; Pyrrolidines; Receptors, Opioid, kappa; Self Administration; Substance-Related Disorders | 1997 |
The role of delta-opioid receptors in the discriminative stimulus properties of a low dose of methamphetamine.
Topics: Animals; Benzylidene Compounds; Central Nervous System Stimulants; Discrimination, Psychological; Dose-Response Relationship, Drug; Male; Methamphetamine; Naltrexone; Quinolines; Rats; Rats, Inbred F344; Receptors, Opioid, delta | 1997 |
[Central K1-opiate receptors and mechanisms of arrhythmogenesis].
Topics: Animals; Arrhythmias, Cardiac; Blood-Brain Barrier; Brain; Dynorphins; Ganglionic Blockers; Heart; Hexamethonium; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Parasympathetic Nervous System; Rats; Rats, Wistar; Receptors, Opioid, kappa | 1997 |
Effect of enterostatin and kappa-opioids on macronutrient selection and consumption.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Butorphanol; Colipases; Dietary Carbohydrates; Dietary Fats; Eating; Enzyme Precursors; Food Preferences; Male; Naltrexone; Narcotic Antagonists; Narcotics; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa | 1997 |
Food intake and food choice: the role of the endogenous opioid peptides in the marsupial Sminthopsis crassicaudata.
Topics: Animals; Diet; Eating; Endorphins; Energy Intake; Food Preferences; Male; Marsupialia; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1997 |
Butorphanol-mediated antinociception in mice: partial agonist effects and mu receptor involvement.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Butorphanol; Male; Mice; Morphine; Naltrexone; Pyrrolidines; Receptors, Opioid, mu | 1997 |
Interleukin-6 is differently modulated by central opioid receptor subtypes.
Topics: Animals; Cerebral Ventricles; Humans; Injections, Intraperitoneal; Injections, Intraventricular; Interleukin-1; Interleukin-6; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Proteins | 1997 |
Antinociceptive effects of morphine and U-50,488H on vaginal distension in the anesthetized rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia; Animals; Blood Pressure; Cardiovascular System; Estrus; Female; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vaginal Diseases | 1997 |
Nor-binaltorphimine precipitates withdrawal and excitatory amino acid release in the locus ceruleus of butorphanol--but not morphine-dependent rats.
Topics: Animals; Butorphanol; Excitatory Amino Acids; Locus Coeruleus; Male; Microdialysis; Morphine Dependence; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Substance Withdrawal Syndrome | 1997 |
Evaluation of opioid receptor subtype antagonist effects in the ventral tegmental area upon food intake under deprivation, glucoprivic and palatable conditions.
Topics: Deoxyglucose; Eating; Enkephalin, Leucine-2-Alanine; Evaluation Studies as Topic; Food Deprivation; Hyperphagia; Insulin; Naltrexone; Narcotic Antagonists; Sucrose; Ventral Tegmental Area | 1997 |
The effect of blockade of kappa-opioid receptors in the medial preoptic area on the luteinizing hormone surge in the proestrous rat.
Topics: Animals; Female; Luteinizing Hormone; Naltrexone; Narcotic Antagonists; Norepinephrine; Ovulation; Preoptic Area; Proestrus; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Secretory Rate | 1997 |
Anatomical distribution of mu, delta, and kappa opioid- and nociceptin/orphanin FQ-stimulated [35S]guanylyl-5'-O-(gamma-thio)-triphosphate binding in guinea pig brain.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Non-Narcotic; Animals; Autoradiography; Brain Chemistry; Cerebellum; Diencephalon; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Male; Medulla Oblongata; Mesencephalon; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptin; Opioid Peptides; Pons; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sulfur Radioisotopes; Telencephalon | 1997 |
Conditioned immunomodulation: investigations of the role of endogenous activity at mu, kappa, and delta opioid receptor subtypes.
Topics: Animals; Avoidance Learning; Cell Division; Conditioning, Classical; Electroshock; Immune System; Killer Cells, Natural; Lipopolysaccharides; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Lew; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spleen | 1997 |
Antinociceptive effects of (+)-matrine in mice.
Topics: Abdomen; Alkaloids; Analgesics; Animals; Male; Matrines; Mice; Mice, Inbred ICR; Muscle Contraction; Naltrexone; Narcotic Antagonists; Pain Measurement; Quinolizines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tail | 1997 |
Kappa-opioid restraint of oxytocin secretion: plasticity through pregnancy.
Topics: Animals; Basal Metabolism; Cholecystokinin; Female; Naloxone; Naltrexone; Oxytocin; Pregnancy; Pregnancy, Animal; Rats; Rats, Wistar; Receptors, Opioid, kappa; Receptors, Opioid, mu; Secretory Rate | 1997 |
Differential response to kappa-opioidergic agents in dietary fat selection between Osborne-Mendel and S5B/P1 rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Brain; Diet; Dietary Fats; Eating; Energy Metabolism; Food Preferences; Male; Naltrexone; Narcotic Antagonists; Narcotics; Obesity; Rats; Rats, Inbred Strains; Receptors, Opioid, kappa | 1998 |
Kappa receptor activation attenuates L-trans-pyrrolidine-2,4-dicarboxylic acid-evoked glutamate levels in the striatum.
Topics: Animals; Benzeneacetamides; Calcium; Corpus Striatum; Dicarboxylic Acids; Glutamic Acid; Kinetics; Male; Microdialysis; Naltrexone; Neurotransmitter Uptake Inhibitors; Perfusion; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, kappa | 1998 |
Suppression of cAMP by phosphoinositol/Ca2+ pathway in the cardiac kappa-opioid receptor.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylate Cyclase Toxin; Animals; Calcimycin; Calcium; Cells, Cultured; Chelating Agents; Colforsin; Cyclic AMP; Egtazic Acid; Heart; Heart Ventricles; Kinetics; Male; Myocardium; Naltrexone; Narcotic Antagonists; Pertussis Toxin; Phosphatidylinositols; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Signal Transduction; Virulence Factors, Bordetella | 1998 |
Differential involvement of opioid receptors in intrathecal butorphanol-induced analgesia: compared to morphine.
Topics: Analgesics, Opioid; Animals; Butorphanol; Dose-Response Relationship, Drug; Injections, Spinal; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid | 1998 |
U50,488H inhibits effects of norepinephrine in rat cardiomyocytes-cross-talk between kappa-opioid and beta-adrenergic receptors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic beta-Agonists; Animals; Bucladesine; Calcium; Colforsin; Electric Stimulation; GTP-Binding Proteins; In Vitro Techniques; Intracellular Fluid; Myocardial Contraction; Myocardium; Naltrexone; Norepinephrine; Pertussis Toxin; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; Receptors, Opioid, kappa; Type C Phospholipases; Virulence Factors, Bordetella | 1998 |
Evidence that spinal endogenous opioidergic systems control the expression of chronic pain-related behaviors in spinally injured rats.
Topics: Animals; Behavior, Animal; Chronic Disease; Cold Temperature; Female; Hyperalgesia; Injections, Spinal; Naltrexone; Narcotic Antagonists; Pain; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Self Mutilation; Somatostatin; Spinal Cord Injuries; Stress, Mechanical | 1998 |
Ischemic preconditioning in the intact rat heart is mediated by delta1- but not mu- or kappa-opioid receptors.
Topics: Animals; Benzylidene Compounds; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hemodynamics; Ischemic Preconditioning, Myocardial; Male; Myocardial Infarction; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1998 |
Receptor-mediated activation of G-proteins by kappa opioid agonists in frog (Rana esculenta) brain membranes.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzomorphans; Brain; Cell Membrane; Ethylketocyclazocine; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Kinetics; Naltrexone; Narcotic Antagonists; Rana esculenta; Receptors, Opioid, kappa | 1998 |
Structural features determining differential receptor regulation of neuronal Ca channels.
Topics: Analgesics; Barium; Benzeneacetamides; Calcium Channels; Cell Line; Electrophysiology; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; Ion Channel Gating; Mutagenesis; Naltrexone; Narcotic Antagonists; Neurons; Protein Structure, Tertiary; Pyrrolidines; Receptors, Opioid, kappa; Recombinant Fusion Proteins; Transfection | 1998 |
kappa-Opioid receptor binding populations in rhesus monkey brain: relationship to an assay of thermal antinociception.
Topics: Analgesics, Opioid; Animals; Benzofurans; Brain Chemistry; Butorphanol; Dose-Response Relationship, Drug; Hot Temperature; Macaca mulatta; Nalbuphine; Naltrexone; Pyrrolidines; Radioligand Assay; Receptors, Opioid, kappa | 1998 |
Involvement of kappa-opioids in the mouse cerebellar adenosinergic modulation of ethanol-induced motor incoordination.
Topics: Alcoholic Intoxication; Animals; Axons; Brain Mapping; Cerebellum; Ethanol; GTP-Binding Proteins; Male; Mice; Motor Skills; Naltrexone; Narcotic Antagonists; Postural Balance; Receptors, Opioid, kappa; Receptors, Purinergic P1 | 1998 |
Identification of opioid receptor subtypes in antinociceptive actions of supraspinally-administered mitragynine in mice.
Topics: Analgesics; Animals; Drug Synergism; Injections, Intraventricular; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Pain Measurement; Receptors, Opioid; Receptors, Opioid, mu; Secologanin Tryptamine Alkaloids | 1998 |
The role of mu and kappa opioid receptors within the periaqueductal gray in the expression of conditional hypoalgesia.
Topics: Acoustic Stimulation; Analysis of Variance; Animals; Conditioning, Classical; Electroshock; Fear; Male; Microinjections; Naltrexone; Narcotic Antagonists; Pain Threshold; Periaqueductal Gray; Rats; Reaction Time; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1998 |
Supraspinal flumazenil inhibits the antianalgesic action of spinal dynorphin A (1-17).
Topics: Analgesia; Analgesics; Animals; Clonidine; Dose-Response Relationship, Drug; Drug Interactions; Dynorphins; Flumazenil; GABA Agonists; GABA-A Receptor Agonists; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Naltrexone; Physostigmine | 1998 |
Hippocampal dynorphin B injections impair spatial learning in rats: a kappa-opioid receptor-mediated effect.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Hippocampus; Male; Maze Learning; Microinjections; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Spatial Behavior | 1998 |
Gestational and ovarian sex steroid antinociception: synergy between spinal kappa and delta opioid systems.
Topics: Animals; Benzylidene Compounds; Dose-Response Relationship, Drug; Estrogens; Female; Naltrexone; Narcotic Antagonists; Ovary; Pain Threshold; Pregnancy; Pregnancy, Animal; Progesterone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Spinal Cord | 1998 |
Opioids modulate the calcitonin gene-related peptide8-37-mediated hindpaw withdrawal latency increase in thermally injured rats.
Topics: Animals; Brain Chemistry; Burns; Calcitonin Gene-Related Peptide; Hindlimb; Injections, Spinal; Male; Mitogens; Naltrexone; Narcotic Antagonists; Nociceptors; Pain; Peptide Fragments; Pressure; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reflex | 1998 |
Comparative hypotensive actions of three nonpeptide kappa opioid agonists on hippocampus of SHRs and normotensive WKY rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Antihypertensive Agents; Benzomorphans; Dose-Response Relationship, Drug; Hippocampus; Male; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Opioid, kappa | 1998 |
Dynorphin uses a non-opioid mechanism to potentiate N-methyl-D-aspartate currents in single rat periaqueductal gray neurons.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Action Potentials; Analgesics, Non-Narcotic; Animals; Drug Synergism; Dynorphins; N-Methylaspartate; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Patch-Clamp Techniques; Peptide Fragments; Periaqueductal Gray; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa | 1998 |
The role of subtypes of the opioid receptor in the anxiolytic action of chlordiazepoxide.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Chlordiazepoxide; Male; Mice; Naltrexone; Narcotic Antagonists; Receptors, Opioid | 1998 |
Role of opioids in hypoxic pial artery dilation is stimulus duration dependent.
Topics: Animals; Arteries; Dynorphins; Enkephalin, Methionine; Female; Hypoxia, Brain; Male; Naltrexone; Narcotic Antagonists; Opioid Peptides; Pia Mater; Swine; Vasodilation | 1998 |
Involvement of mu- and delta-opioid receptors in the ethanol-associated place preference in rats exposed to foot shock stress.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Ethanol; Exploratory Behavior; Foot; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Morphine; Naloxone; Naltrexone; Narcotics; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu | 1998 |
Kappa-opioid potentiation of tumor necrosis factor-alpha-induced anti-HIV-1 activity in acutely infected human brain cell cultures.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Antiviral Agents; Brain; Cells, Cultured; Drug Synergism; HIV-1; Humans; Interleukin-1; Naltrexone; Receptors, Opioid, kappa; Tumor Necrosis Factor-alpha | 1998 |
Orphanin FQ/nociceptin inhibits synaptic transmission and long-term potentiation in rat dentate gyrus through postsynaptic mechanisms.
Topics: Action Potentials; Animals; Dentate Gyrus; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Long-Term Potentiation; Male; N-Methylaspartate; Naloxone; Naltrexone; Narcotic Antagonists; Neural Inhibition; Nociceptin; Opioid Peptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Synapses; Synaptic Transmission; Tetrodotoxin | 1998 |
Relationship between inhibitory effect of endogenous opioid via mu-receptors and muscarinic autoinhibition in acetylcholine release from myenteric plexus of guinea pig ileum.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetylcholine; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Atropine; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphinans; Muscarine; Muscarinic Agonists; Muscarinic Antagonists; Muscle, Smooth; Myenteric Plexus; Naltrexone; Narcotic Antagonists; Opioid Peptides; Receptors, Muscarinic; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1998 |
Sex differences in opioid and N-methyl-D-aspartate mediated non-opioid biting fly exposure induced analgesia in deer mice.
Topics: Amino Acids; Analgesia; Analysis of Variance; Animals; Behavior, Animal; Excitatory Amino Acid Antagonists; Female; Houseflies; Insect Bites and Stings; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Peromyscus; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa; Sex Characteristics; Stress, Physiological | 1998 |
Identification of L-type calcium channels associated with kappa opioid receptors in human placenta.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Benzeneacetamides; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Calcium Signaling; Cell Membrane; Chorionic Gonadotropin; Chorionic Villi; Culture Techniques; Egtazic Acid; Female; Humans; Isradipine; Naltrexone; Nifedipine; Placenta; Pyrrolidines; Receptors, Opioid, kappa; Trophoblasts | 1998 |
Peripheral component in the enhanced antinociceptive effect of systemic U-69,593, a kappa-opioid receptor agonist in mononeuropathic rats.
Topics: Analgesics; Animals; Benzeneacetamides; Injections, Intravenous; Male; Naltrexone; Narcotic Antagonists; Nerve Compression Syndromes; Pain Measurement; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Sciatic Nerve; Somatostatin | 1998 |
Inhibition of the neuronal nicotinic receptor-mediated current by kappa opioid receptor agonists in PC12 cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Dynorphins; Electric Conductivity; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Naltrexone; Narcotic Antagonists; Neurons; Nicotinic Antagonists; PC12 Cells; Rats; Receptors, Nicotinic; Receptors, Opioid, kappa | 1998 |
Phospholipase C inhibitors attenuate arrhythmias induced by kappa-receptor stimulation in the isolated rat heart.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Arrhythmias, Cardiac; Calcium; Enzyme Inhibitors; Estrenes; Heart Rate; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Male; Naltrexone; Narcotic Antagonists; Neomycin; Pertussis Toxin; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Signal Transduction; Streptomycin; Type C Phospholipases; Virulence Factors, Bordetella | 1998 |
kappa-opioid regulation of neuronal activity in the rat supraoptic nucleus in vivo.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Cells, Cultured; Dendrites; Down-Regulation; Dynorphins; Electrophysiology; Female; Injections, Intravenous; Membrane Potentials; Microdialysis; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Oxytocin; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Supraoptic Nucleus; Vasopressins | 1998 |
5-HT4 receptor agonists and delta-opioid receptor antagonists act synergistically to stimulate colonic propulsion.
Topics: Animals; Benzeneacetamides; Colon; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Guinea Pigs; In Vitro Techniques; Male; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Peptide Fragments; Peristalsis; Pyrrolidines; Receptors, Opioid, delta; Receptors, Serotonin; Receptors, Serotonin, 5-HT4; Serotonin Receptor Agonists; Somatostatin | 1998 |
Ameliorative effects of tachykinins on scopolamine-induced impairment of spontaneous alternation performance in mice.
Topics: Animals; Male; Mice; Muscarinic Antagonists; Naloxone; Naltrexone; Narcotic Antagonists; Neurokinin A; Peptide Fragments; Psychomotor Performance; Scopolamine; Substance P; Tachykinins | 1998 |
Kappa-opioid receptor blockade with nor-binaltorphimine modulates cocaine self-administration in drug-naive rats.
Topics: Animals; Behavior, Animal; Cocaine; Dose-Response Relationship, Drug; Male; Naltrexone; Narcotics; Nicotinic Antagonists; Rats; Rats, Wistar; Receptors, Opioid, kappa; Self Administration; Time Factors | 1998 |
Mutational evidence for a common kappa antagonist binding pocket in the wild-type kappa and mutant mu[K303E] opioid receptors.
Topics: Amino Acid Sequence; Animals; Binding, Competitive; COS Cells; Guanidines; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Models, Molecular; Molecular Conformation; Molecular Sequence Data; Morphinans; Muscle, Smooth; Mutation; Naltrexone; Narcotic Antagonists; Rats; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vas Deferens | 1998 |
Intrathecal administration of p-hydroxymercuribenzoate or phosphoramidon/bestatin-combined induces antinociceptive effects through different opioid mechanisms.
Topics: Animals; Capsaicin; Dose-Response Relationship, Drug; Drug Combinations; Glycopeptides; Hindlimb; Hydroxymercuribenzoates; Injections, Spinal; Leucine; Male; Mice; Mice, Inbred Strains; Naltrexone; Narcotic Antagonists; Pain; Protease Inhibitors; Receptors, Opioid; Time Factors | 1998 |
Regulation of cocaine reward by CREB.
Topics: Animals; Cocaine; Conditioning, Psychological; Cyclic AMP Response Element-Binding Protein; Dose-Response Relationship, Drug; Dynorphins; Gene Expression; Gene Expression Regulation; Gene Transfer Techniques; Genetic Vectors; Naltrexone; Narcotic Antagonists; Neurons; Nucleus Accumbens; Point Mutation; Rats; Receptors, Opioid, kappa; Reward; RNA, Messenger; Simplexvirus | 1998 |
Endomorphin-1 and endomorphin-2 activate mu-opioid receptors in myenteric neurons of the guinea-pig small intestine.
Topics: Acetylcholine; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Electric Stimulation; Female; Guinea Pigs; Ileum; Intestine, Small; Male; Myenteric Plexus; Naltrexone; Oligopeptides; Receptors, Opioid, mu; Regression Analysis; Somatostatin | 1998 |
Effect of mu-selective opioid antagonists on MIP-1 beta and IL-1 beta-induced fever.
Topics: Animals; Body Temperature; Chemokine CCL4; Fever; Interleukin-1; Macrophage Inflammatory Proteins; Male; Naltrexone; Narcotic Antagonists; Peptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 1998 |
Opioid efficacy in a C6 glioma cell line stably expressing the human kappa opioid receptor.
Topics: Analgesics, Opioid; Animals; Benzeneacetamides; Glioma; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Ligands; Naloxone; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rats; Receptors, Opioid, kappa; Stereoisomerism; Transfection; Tritium; Tumor Cells, Cultured | 1999 |
Stereoselective mu- and delta-opioid receptor-related antinociception and binding with (+)-thebaine.
Topics: Analgesics; Animals; Binding, Competitive; Cells, Cultured; Epilepsy; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Pain Measurement; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Stereoisomerism; Thebaine | 1999 |
Role of the kappa-opioid system in the attenuation of the morphine-induced place preference under chronic pain.
Topics: Animals; Chronic Disease; Conditioning, Psychological; Formaldehyde; Hindlimb; Inflammation; Male; Morphine; Naltrexone; Pain; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Reward; Time Factors | 1999 |
Dynorphin A increases substance P release from trigeminal primary afferent C-fibers.
Topics: Animals; Animals, Newborn; Capsaicin; Dizocilpine Maleate; Dynorphins; Enkephalin, Leucine; Excitatory Amino Acid Antagonists; In Vitro Techniques; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nerve Fibers; Neurons, Afferent; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Substance P; Trigeminal Nuclei | 1999 |
Differential effects of mu and kappa opioid antagonists on Fos-like immunoreactivity in extended amygdala.
Topics: Amygdala; Animals; Antibodies; Behavior, Animal; Feeding Behavior; Injections, Intraventricular; Male; Motivation; Naltrexone; Narcotic Antagonists; Peptide Fragments; Peptides; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin | 1999 |
Activation of peripheral kappa opioid receptors inhibits capsaicin-induced thermal nociception in rhesus monkeys.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Azocines; Benzomorphans; Capsaicin; Dynorphins; Female; Hot Temperature; Ligands; Macaca mulatta; Male; Naltrexone; Narcotic Antagonists; Pain Measurement; Peptide Fragments; Receptors, Opioid, kappa | 1999 |
Effects of U50488 and bremazocine on [Ca2+]i and cAMP in naive and tolerant rat ventricular myocytes: evidence of kappa opioid receptor multiplicity in the heart.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Azocines; Benzomorphans; Calcium; Cells, Cultured; Colforsin; Cyclic AMP; Drug Resistance; Electric Stimulation; Heart; Heart Ventricles; Male; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa | 1999 |
Effects of opioid receptor antagonists on the effects of i.v. morphine on carrageenin evoked c-Fos expression in the superficial dorsal horn of the rat spinal cord.
Topics: Analgesics, Opioid; Animals; Carrageenan; Hindlimb; Inflammation; Injections, Intravenous; Male; Morphine; Naltrexone; Narcotic Antagonists; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin; Spinal Cord | 1999 |
[Opiatergic mechanisms of cardioprotective and anti-arrhythmic effects of adaptation].
Topics: Adaptation, Physiological; Animals; Arrhythmias, Cardiac; Enkephalin, Leucine; Epinephrine; Heart; Hypoxia; Immobilization; Male; Naltrexone; Narcotic Antagonists; Plant Extracts; Rats; Rats, Wistar | 1999 |
Spinal administration of selective opioid antagonists in amphibians: evidence for an opioid unireceptor.
Topics: Acetic Acid; Analgesics; Animals; Benzofurans; Female; Injections, Spinal; Male; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain Measurement; Pyrrolidines; Rana pipiens; Receptors, Opioid; Time Factors | 1999 |
Different roles of mu-, delta- and kappa-opioid receptors in ethanol-associated place preference in rats exposed to conditioned fear stress.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Behavior, Animal; Central Nervous System Depressants; Conditioning, Psychological; Ethanol; Fear; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stress, Psychological | 1999 |
Immunomodulatory action of class mu-, delta- and kappa-opioid receptor agonists in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Immunity; Lymphocyte Activation; Male; Mice; Mice, Inbred C57BL; Mitogens; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; T-Lymphocytes | 1998 |
[A molecular mechanism for supersensitization of adenylyl cyclase system in cloned opioid receptor-transfected cells following sustained opioid treatment].
Topics: Adenylyl Cyclases; Analgesics; Animals; Atropine; Benzeneacetamides; Carbachol; CHO Cells; Clone Cells; Cricetinae; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP Phosphohydrolases; Morphine; Muscarinic Agonists; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Transfection | 1998 |
Opioidergic modulation of voltage-activated K+ currents in magnocellular neurons of the supraoptic nucleus in rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Ion Channel Gating; Membrane Potentials; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Patch-Clamp Techniques; Potassium Channels; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Supraoptic Nucleus | 1999 |
Spinal blockade of opioid receptors prevents the analgesia produced by TENS in arthritic rats.
Topics: Animals; Arthritis; Behavior, Animal; Carrageenan; Injections, Intra-Articular; Kaolin; Male; Microdialysis; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord; Transcutaneous Electric Nerve Stimulation | 1999 |
Analgesia-producing mechanism of processed Aconiti tuber: role of dynorphin, an endogenous kappa-opioid ligand, in the rodent spinal cord.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Administration, Topical; Analgesics; Animals; Arcuate Nucleus of Hypothalamus; Cold Temperature; Dexamethasone; Dopamine Antagonists; Drugs, Chinese Herbal; Dynorphins; Glucocorticoids; Hypothalamus; Immune Sera; Ligands; Male; Mice; Naltrexone; Narcotic Antagonists; Nociceptors; Pain; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Salicylamides; Spinal Cord; Sulpiride | 1999 |
Effects of U-69,593, a kappa-opioid receptor agonist, on carrageenin-induced peripheral oedema and Fos expression in the rat spinal cord.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Benzeneacetamides; Carrageenan; Dose-Response Relationship, Drug; Drug Interactions; Edema; Immunochemistry; Inflammation; Male; Naltrexone; Narcotic Antagonists; Photomicrography; Proto-Oncogene Proteins c-fos; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Spinal Cord | 1999 |
Control of glutamate release by calcium channels and kappa-opioid receptors in rodent and primate striatum.
Topics: 4-Aminopyridine; Animals; Benzofurans; Calcium Channel Blockers; Calcium Channels; Callithrix; Glutamic Acid; In Vitro Techniques; Male; Naltrexone; Narcotic Antagonists; Neostriatum; omega-Agatoxin IVA; omega-Conotoxin GVIA; Peptides; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Spider Venoms; Synaptosomes; Tetrodotoxin | 1999 |
Cardioprotection of preconditioning by metabolic inhibition in the rat ventricular myocyte. Involvement of kappa-opioid receptor.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Calcium; Cell Survival; Electrophysiology; Energy Metabolism; Heart Ventricles; In Vitro Techniques; Ischemic Preconditioning, Myocardial; Membrane Potentials; Muscle Fibers, Skeletal; Myocardial Contraction; Myocardial Ischemia; Myocardium; Naltrexone; Narcotic Antagonists; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Trypan Blue | 1999 |
Supersensitization of the adenylyl cyclase system in Chinese hamster ovary cells co-expressing cloned opioid receptors and Gz, a PTX-insensitive G protein.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Benzeneacetamides; CHO Cells; Cricetinae; Cyclic AMP; Enzyme Activation; Female; GTP-Binding Protein alpha Subunits; Heterotrimeric GTP-Binding Proteins; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pertussis Toxin; Pyrrolidines; Receptors, Opioid; Virulence Factors, Bordetella | 1999 |
Naloxone blocks endomorphin-1 but not endomorphin-2 induced inhibition of tachykinergic contractions of guinea-pig isolated bronchus.
Topics: Analgesics, Opioid; Animals; Bronchi; Capsaicin; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Naloxone; Naltrexone; Narcotic Antagonists; Neurokinin A; Oligopeptides; Receptors, Opioid, mu; Tachykinins | 1999 |
Ligands for opioid and sigma-receptors improve cardiac electrical stability in rat models of post-infarction cardiosclerosis and stress.
Topics: Animals; Anti-Arrhythmia Agents; beta-Endorphin; Disease Models, Animal; Dynorphins; Enkephalin, Leucine-2-Alanine; Heart; Immobilization; Ligands; Morphine; Myocardial Infarction; Myocardium; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Piperidines; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, delta; Stress, Physiological; Ventricular Fibrillation | 1999 |
kappa-Opioid tolerance and dependence in cultures of dopaminergic midbrain neurons.
Topics: Analgesics; Analysis of Variance; Animals; Benzeneacetamides; Cells, Cultured; Dopamine; Fetus; Kinetics; Mesencephalon; Naltrexone; Narcotic Antagonists; Neurons; Pertussis Toxin; Potassium; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Regression Analysis; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Tetrodotoxin; Time Factors; Transcription, Genetic; Virulence Factors, Bordetella | 1999 |
Irreversible labelling of the opioid receptors by a melphalan-substituted [Met5]enkephalin-Arg-Phe derivative.
Topics: Affinity Labels; Amino Acid Sequence; Amino Acid Substitution; Animals; Binding Sites; Binding, Competitive; Brain; Enkephalin, Methionine; Female; Guinea Pigs; Male; Melphalan; Membranes; Naloxone; Naltrexone; Narcotic Antagonists; Radioligand Assay; Rats; Receptors, Opioid | 1999 |
Kappa opioid receptor agonists differentially inhibit two classes of rat spinal neurons excited by colorectal distention.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzyl Compounds; Colon; Male; Naltrexone; Propylamines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Rectum; Spinal Cord | 1999 |
Paradoxical effects of intracerebroventricular low-dose opioid antagonists in SHR with chronic pain.
Topics: Analgesia; Animals; Arteries; Blood Pressure; Body Temperature; Body Weight; Brain; Chronic Disease; Hypertension; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Pain Threshold; Quaternary Ammonium Compounds; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 1999 |
Interactions between cholecystokinin and opioids in the isolated guinea-pig ileum.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphinans; Muscle Contraction; Naloxone; Naltrexone; Oligopeptides; Opioid Peptides; Receptor, Cholecystokinin A; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Receptors, Opioid; Sincalide; Substance Withdrawal Syndrome | 1999 |
Differential antagonism of the rate-decreasing effects of kappa-opioid receptor agonists by naltrexone and norbinaltorphimine.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Behavior, Animal; Benzeneacetamides; Benzofurans; Benzomorphans; Conditioning, Operant; Dose-Response Relationship, Drug; Ethylketocyclazocine; Nalorphine; Naltrexone; Narcotic Antagonists; Pyrroles; Pyrrolidines; Receptors, Opioid, kappa; Reinforcement Schedule; Saimiri; Thiophenes | 1999 |
Modulation of neurotransmitter release in the basal ganglia of the rat brain by dynorphin peptides.
Topics: Animals; Basal Ganglia; Dopamine; Dynorphins; Male; Microinjections; Naltrexone; Narcotic Antagonists; Neostriatum; Perfusion; Rats; Rats, Sprague-Dawley; Substantia Nigra | 1999 |
Delta(2)-opioid receptor mediation of morphine-induced CCK release in the frontal cortex of the freely moving rat.
Topics: Analgesics, Opioid; Animals; Cholecystokinin; Extracellular Space; Injections; Ligands; Male; Microdialysis; Morphine; Naltrexone; Narcotic Antagonists; Prefrontal Cortex; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Somatostatin | 1999 |
Presynaptic kappa-opioid and muscarinic receptors inhibit the calcium-dependent component of evoked glutamate release from striatal synaptosomes.
Topics: 4-Aminopyridine; Animals; Calcium; Chelating Agents; Dicarboxylic Acids; Egtazic Acid; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glutamic Acid; In Vitro Techniques; Male; Muscarinic Agonists; Muscarinic Antagonists; Naltrexone; Narcotic Antagonists; Neostriatum; Nerve Endings; Neurotransmitter Uptake Inhibitors; Potassium Channel Blockers; Potassium Channels; Pyrrolidines; Rats; Rats, Wistar; Receptors, Muscarinic; Receptors, Opioid, kappa; Receptors, Presynaptic; Synaptosomes | 1999 |
The kappa-opioid agonist, U-69593, decreases acute amphetamine-evoked behaviors and calcium-dependent dialysate levels of dopamine and glutamate in the ventral striatum.
Topics: Amphetamine; Animals; Behavior, Animal; Benzeneacetamides; Calcium; Dopamine; Glutamic Acid; Male; Microdialysis; Naltrexone; Narcotic Antagonists; Neostriatum; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, kappa | 1999 |
Cannabinoid modulation of dynorphin A: correlation to cannabinoid-induced antinociception.
Topics: Analgesics; Animals; Cannabinoids; Cyclohexanols; Dimethyl Sulfoxide; Dronabinol; Dynorphins; Injections, Spinal; Male; Naltrexone; Narcotic Antagonists; Nociceptors; Pain; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant | 1999 |
Antinociceptive properties of FR140423 mediated through spinal delta-, but not mu- and kappa-, opioid receptors.
Topics: Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Binding, Competitive; Diarrhea; Injections, Intraventricular; Injections, Spinal; Male; Membranes; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Pyrazoles; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord; Sulfoxides | 1999 |
Anti-arrhythmic effect of kappa-opioid receptor stimulation in the perfused rat heart: involvement of a cAMP-dependent pathway.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic beta-Antagonists; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium; Colforsin; Cyclic AMP; Cytosol; Electric Stimulation; Electrocardiography; Heart; Heart Rate; In Vitro Techniques; Male; Myocardial Contraction; Naltrexone; Norepinephrine; Propranolol; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa | 1999 |
Opioid peptide receptor studies. 10. Nor-BNI differentially inhibits kappa receptor agonist-induced G-protein activation in the guinea pig caudate: further evidence of kappa receptor heterogeneity.
Topics: Animals; Benzeneacetamides; Benzodiazepines; Brain; Caudate Nucleus; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; In Vitro Techniques; Inhibitory Concentration 50; Naltrexone; Oligopeptides; Peptide Fragments; Peptides; Pyrrolidines; Rats; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin | 1999 |
Hematopoietic effect of melatonin involvement of type 1 kappa-opioid receptor on bone marrow macrophages and interleukin-1.
Topics: Animals; Antibodies, Monoclonal; Bone Marrow Cells; Cells, Cultured; Colony-Forming Units Assay; Dynorphins; Female; Granulocyte-Macrophage Colony-Stimulating Factor; Granulocytes; Hematopoiesis; Immunohistochemistry; Interleukin-1; Macrophages; Melatonin; Mice; Mice, Inbred C57BL; Naltrexone; Narcotic Antagonists; Oligodeoxyribonucleotides, Antisense; Receptors, Opioid, kappa | 1999 |
Intracisternal nor-binaltorphimine distinguishes central and peripheral kappa-opioid antinociception in rhesus monkeys.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Opioid; Animals; Benzomorphans; Central Nervous System; Cisterna Magna; Dose-Response Relationship, Drug; Female; Hot Temperature; Injections; Macaca mulatta; Male; Naltrexone; Narcotic Antagonists; Peripheral Nervous System; Receptors, Opioid, kappa | 1999 |
Hypoalgesia elicited by a conditioned stimulus is blocked by a mu, but not a delta or a kappa, opioid antagonist injected into the rostral ventromedial medulla.
Topics: Animals; Conditioning, Psychological; Male; Medulla Oblongata; Naltrexone; Narcotic Antagonists; Pain Measurement; Peptide Fragments; Peptides; Rats; Rats, Long-Evans; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin | 1999 |
Identification of the G-protein-coupled ORL1 receptor in the mouse spinal cord by [35S]-GTPgammaS binding and immunohistochemistry.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Atropine; Autoradiography; Baclofen; Binding, Competitive; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Haloperidol; Immunohistochemistry; In Vitro Techniques; Male; Membranes; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Nociceptin; Nociceptin Receptor; Opioid Peptides; Peptide Fragments; Propranolol; Receptors, Opioid; Somatostatin; Spinal Cord; Sulfur Radioisotopes; Yohimbine | 1999 |
A comparative study of the effects of morphine in the dorsal periaqueductal gray and nucleus accumbens of rats submitted to the elevated plus-maze test.
Topics: Analgesics, Opioid; Animals; Conditioning, Psychological; Fear; Male; Maze Learning; Microinjections; Morphine; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Periaqueductal Gray; Rats; Rats, Wistar; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1999 |
The adrenergic receptor agonist, clonidine, potentiates the anti-parkinsonian action of the selective kappa-opioid receptor agonist, enadoline, in the monoamine-depleted rat.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antiparkinson Agents; Benzofurans; Biogenic Monoamines; Clonidine; Disease Models, Animal; Drug Combinations; Drug Synergism; Locomotion; Male; Naltrexone; Narcotic Antagonists; Parkinson Disease, Secondary; Prazosin; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reserpine; Yohimbine | 1999 |
ATP-gated K(+) channel openers enhance opioid antinociception: indirect evidence for the release of endogenous opioid peptides.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenosine Triphosphate; Analgesics; Animals; Cromakalim; Diazoxide; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Glyburide; Injections, Intraventricular; Ion Channel Gating; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Narcotic Antagonists; Nociceptors; Opioid Peptides; Pain; Potassium Channels; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin | 1999 |
Dynorphin A (1-13) neurotoxicity in vitro: opioid and non-opioid mechanisms in mouse spinal cord neurons.
Topics: Analgesics, Opioid; Animals; Calcium; Cell Survival; Dizocilpine Maleate; Dynorphins; Embryo, Mammalian; Kynurenic Acid; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Neurotoxins; Peptide Fragments; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Valine | 1999 |
kappa-Opioid receptors in the substantia nigra pars reticulata mediate the U-50,488-induced locomotor activity of preweanling rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Animals, Newborn; Behavior, Animal; Dose-Response Relationship, Drug; Female; Male; Microinjections; Motor Activity; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid, kappa; Substantia Nigra | 2000 |
Enhanced delta-opioid receptor-mediated antinociception in mu-opioid receptor-deficient mice.
Topics: Analgesia; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Hyperalgesia; Mice; Mice, Inbred C57BL; Mice, Knockout; Naltrexone; Receptors, Opioid, delta; Receptors, Opioid, mu | 2000 |
Dynorphin A enhances mitogen-induced proliferative response and interleukin-2 production of rat splenocytes.
Topics: Analgesics, Opioid; Animals; Cells, Cultured; Concanavalin A; Dynorphins; Interleukin-2; Lymphocyte Activation; Lymphocytes; Male; Naloxone; Naltrexone; Narcotic Antagonists; Peptide Fragments; Rats; Rats, Sprague-Dawley; Spleen | 1999 |
Tritiated kappa receptor antagonist norbinal torphimine: synthesis and in vitro binding in three different tissues.
Topics: Animals; Anura; Binding, Competitive; Brain; Cell Membrane; Guinea Pigs; Naltrexone; Narcotic Antagonists; Radioligand Assay; Rats; Receptors, Opioid, kappa; Species Specificity; Tritium | 2000 |
Selective mu and delta, but not kappa, opiate receptor antagonists inhibit the habituation of novelty-induced hypoalgesia in the rat.
Topics: Animals; Dose-Response Relationship, Drug; Habituation, Psychophysiologic; Male; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Rats; Rats, Wistar; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin | 2000 |
U50,488 protection against HIV-1-related neurotoxicity: involvement of quinolinic acid suppression.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; AIDS Dementia Complex; Brain; Cells, Cultured; Cerebral Cortex; Fetus; HIV Core Protein p24; HIV-1; Humans; Microglia; Naltrexone; Narcotic Antagonists; Neuroprotective Agents; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa | 2000 |
Kappa-opioid receptor stimulation increases the expression of Na+-H+ exchange gene in the heart.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Gene Expression Regulation; Hydrogen-Ion Concentration; Male; Myocardium; Naltrexone; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Sodium-Hydrogen Exchangers | 2000 |
An interaction of opioids and galanin in dorsal horn of the spinal cord in mononeuropathic rats.
Topics: Animals; Galanin; Hindlimb; Injections, Spinal; Male; Mononeuropathies; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pain Measurement; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Spinal Cord | 2000 |
Changes in analgesia-producing mechanism of repeated cold stress loading in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Anti-Anxiety Agents; Anxiety; Cold Temperature; Diazepam; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Pain Threshold; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stress, Physiological | 2000 |
Mechanical activation of dorsal root ganglion cells in vitro: comparison with capsaicin and modulation by kappa-opioids.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amiloride; Animals; Benzyl Compounds; Calcium; Capsaicin; Cells, Cultured; Gadolinium; Ganglia, Spinal; In Vitro Techniques; Kinetics; Male; Naltrexone; Neurons; Physical Stimulation; Propylamines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa | 2000 |
Dynorphin A-(1-13) and (2-13) improve beta-amyloid peptide-induced amnesia in mice.
Topics: Amnesia; Amyloid beta-Peptides; Animals; Avoidance Learning; Behavior, Animal; Dynorphins; Male; Maze Learning; Mice; Naltrexone; Narcotic Antagonists; Narcotics; Peptide Fragments; Reaction Time | 2000 |
Enhancement of natural immunity seen after voluntary exercise in rats. Role of central opioid receptors.
Topics: Animals; Immunity, Innate; Injections, Intraventricular; Naltrexone; Narcotic Antagonists; Physical Conditioning, Animal; Rats; Receptors, Opioid | 2000 |
Activation of c-fos expression in hypothalamic nuclei by mu- and kappa-receptor agonists: correlation with catecholaminergic activity in the hypothalamic paraventricular nucleus.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Male; Methoxyhydroxyphenylglycol; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Norepinephrine; Paraventricular Hypothalamic Nucleus; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Suprachiasmatic Nucleus; Supraoptic Nucleus | 2000 |
Concurrent modulation of anxiety and memory.
Topics: Animals; Anxiety; Behavior, Animal; Limbic System; Male; Maze Learning; Memory; Mice; Mice, Inbred Strains; Microinjections; Naltrexone; Narcotic Antagonists; Prefrontal Cortex; Random Allocation; Receptors, Opioid, kappa | 2000 |
Inhibitory effect of intracerebroventricularly-administered [D-Arg(2), beta-Ala(4)]-dermorphin (1-4) on gastrointestinal transit.
Topics: Analgesics; Animals; Charcoal; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Female; Gastrointestinal Transit; Injections, Intraventricular; Mice; Mice, Inbred Strains; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides | 2000 |
Fedotozine, a kappa-opioid agonist, prevents spinal and supra-spinal Fos expression induced by a noxious visceral stimulus in the rat.
Topics: Abdominal Pain; Acetic Acid; Afferent Pathways; Animals; Benzyl Compounds; Brain; Capsaicin; Gene Expression Regulation; Genes, fos; Injections, Intraperitoneal; Intestinal Obstruction; Male; Naltrexone; Paraventricular Hypothalamic Nucleus; Propylamines; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Solitary Nucleus; Spinal Cord; Supraoptic Nucleus | 2000 |
Binding of norbinaltorphimine (norBNI) congeners to wild-type and mutant mu and kappa opioid receptors: molecular recognition loci for the pharmacophore and address components of kappa antagonists.
Topics: Amino Acid Substitution; Animals; Cloning, Molecular; COS Cells; Glutamic Acid; Ligands; Models, Molecular; Mutagenesis, Site-Directed; Naltrexone; Narcotic Antagonists; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship; Transfection | 2000 |
Improvement by low doses of nociceptin on scopolamine-induced impairment of learning and/or memory.
Topics: Analgesics, Opioid; Animals; Avoidance Learning; Disease Models, Animal; Dizocilpine Maleate; Learning Disabilities; Male; Maze Learning; Memory Disorders; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Neuroprotective Agents; Nociceptin; Opioid Peptides; Psychomotor Performance; Rats; Scopolamine | 2000 |
Effects of endomorphins-1 and -2, endogenous mu-opioid receptor agonists, on spontaneous alternation performance in mice.
Topics: Analgesics, Opioid; Animals; Injections, Intraventricular; Male; Mice; Naltrexone; Narcotic Antagonists; Oligopeptides; Psychomotor Performance; Receptors, Opioid, mu | 2000 |
The effects of highly selective opioid receptor antagonists on the release of arginine vasotocin induced by hyperosmotic stimulation and angiotensin II injection.
Topics: Angiotensin II; Animals; Chickens; Male; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Saline Solution, Hypertonic; Vasotocin | 2000 |
Selective opioid receptor agonist and antagonist displacement of [3H]naloxone binding in amphibian brain.
Topics: Animals; Binding, Competitive; Brain; Dose-Response Relationship, Drug; Kinetics; Naloxone; Naltrexone; Narcotic Antagonists; Radioligand Assay; Rana pipiens; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tritium | 2000 |
Altered opioid-mediated control of the spinal release of dynorphin and met-enkephalin in polyarthritic rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia; Animals; Arthritis; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Iodine Radioisotopes; Ligands; Male; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 2000 |
Receptor selectivity of Met-enkephalin-Arg6-Phe7, an endogenous opioid peptide, in cerebral cortex of human and rat.
Topics: Adult; Animals; Benzeneacetamides; Benzomorphans; Binding Sites; Cerebral Cortex; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Ethylketocyclazocine; Female; Humans; Male; Naloxone; Naltrexone; Norepinephrine; Oligopeptides; Peptide Fragments; Peptides; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Somatostatin | 2000 |
Further characterization of the discriminative stimulus effects of spiradoline.
Topics: Analgesics, Non-Narcotic; Animals; Benzeneacetamides; Discrimination Learning; Drug Interactions; Male; Morphine; Naltrexone; Narcotic Antagonists; Nicotinic Antagonists; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Tetrahydronaphthalenes | 2000 |
Involvement of central opioid systems in human interferon-alpha induced immobility in the mouse forced swimming test.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Interferon-alpha; Interferon-beta; Interferon-gamma; Male; Mice; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Swimming; Time Factors | 2000 |
Cocaine-like discriminative stimulus effects of heroin in squirrel monkeys: role of active metabolites and opioid receptor mechanisms.
Topics: Analgesics, Opioid; Animals; Cocaine; Discrimination Learning; Dopamine Uptake Inhibitors; Heroin; Male; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Saimiri | 2000 |
Chronic blockade of hippocampal kappa receptors increases arterial pressure in conscious spontaneously hypertensive rats but not in normotensive Wistar Kyoto rats.
Topics: Animals; Blood Pressure; Heart Rate; Hippocampus; Hypertension; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Opioid, kappa | 2000 |
Differential involvement of opioid receptors in stress-induced antinociception caused by repeated exposure to forced walking stress in mice.
Topics: Animals; Formaldehyde; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Receptors, Opioid; Stress, Physiological; Walking | 2000 |
BU48: a novel buprenorphine analog that exhibits delta-opioid-mediated convulsions but not delta-opioid-mediated antinociception in mice.
Topics: Analgesics, Opioid; Animals; Benzamides; Brain; Buprenorphine; Convulsants; Electric Stimulation; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Muscle Contraction; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Pain Measurement; Piperazines; Radioligand Assay; Rats; Receptors, Opioid, delta; Receptors, Opioid, kappa; Seizures; Vas Deferens | 2000 |
Synthesis and antinociceptive activity of pyrrolidinylnaphthalenes.
Topics: Analgesics; Animals; Drug Design; Male; Mice; Molecular Structure; Motor Activity; Naloxone; Naltrexone; Naphthalenes; Narcotic Antagonists; Pyrrolidines; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship | 2000 |
Kappa-opioid receptor modulation of nicotine-induced behaviour.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Behavior, Animal; Benzeneacetamides; Benzofurans; Dose-Response Relationship, Drug; Injections, Intraventricular; Male; Motor Activity; Naltrexone; Nicotine; Nicotinic Agonists; Pyrrolidines; Rats; Receptors, Opioid, kappa | 2000 |
The first suckling episode in the rat: the role of endogenous activity at mu and kappa opioid receptors.
Topics: Animals; Feeding Behavior; Female; Injections, Intraventricular; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin; Sucking Behavior | 2000 |
Spinal kappa-opioid system plays an important role in suppressing morphine withdrawal syndrome in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Male; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid, kappa; Substance Withdrawal Syndrome | 2000 |
Dose- and time-dependent bimodal effects of kappa-opioid agonists on locomotor activity in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetamides; Animals; Benzomorphans; Dose-Response Relationship, Drug; Isothiocyanates; Male; Mice; Morphine; Motor Activity; Naloxone; Naltrexone; Receptors, Opioid, kappa; Time Factors | 2000 |
The role of opioid receptors in morphine withdrawal in the infant rat.
Topics: Animals; Animals, Newborn; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Long-Evans; Receptors, Opioid; Receptors, Opioid, mu; Somatostatin; Substance Withdrawal Syndrome | 2000 |
Kappa-opioid receptor activation modifies dopamine uptake in the nucleus accumbens and opposes the effects of cocaine.
Topics: Analysis of Variance; Animals; Autoradiography; Benzeneacetamides; Carrier Proteins; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Drug Administration Schedule; Drug Antagonism; Extracellular Space; Injections, Intraperitoneal; Injections, Subcutaneous; Iodine Radioisotopes; Linear Models; Male; Membrane Glycoproteins; Membrane Transport Proteins; Microdialysis; Naltrexone; Nerve Tissue Proteins; Nucleus Accumbens; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa | 2000 |
Blockade of mu-opioid receptors reveals the hyperalgesic effect of orphanin FQ/nociceptin in the rat hot plate test.
Topics: Animals; Dose-Response Relationship, Drug; Female; Hot Temperature; Hyperalgesia; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptin; Opioid Peptides; Pain Measurement; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid, mu; Somatostatin | 2000 |
Antinociceptive effect produced by intracerebroventricularly administered dynorphin A is potentiated by p-hydroxymercuribenzoate or phosphoramidon in the mouse formalin test.
Topics: Animals; Brain; Cell Extracts; Drug Interactions; Dynorphins; Glycopeptides; Hydroxymercuribenzoates; Injections, Intraventricular; Mice; Naltrexone; Narcotic Antagonists; Nociceptors; Pain; Pain Measurement; Protease Inhibitors; Rats | 2001 |
The selective kappa-opioid receptor agonist U50,488H attenuates voluntary ethanol intake in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Alcohol Drinking; Animals; Central Nervous System Depressants; Depression, Chemical; Drinking; Ethanol; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Lew; Receptors, Opioid, kappa | 2001 |
Place aversion induced by blockade of mu or activation of kappa opioid receptors in the dorsal periaqueductal gray matter.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analysis of Variance; Animals; Behavior, Animal; Conditioning, Operant; Dose-Response Relationship, Drug; Male; Morphine; Naltrexone; Periaqueductal Gray; Rats; Rats, Wistar; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin | 2000 |
Kappa-opioid receptors and relapse-like drinking in long-term ethanol-experienced rats.
Topics: Alcohol Drinking; Animals; Benzofurans; Conditioning, Operant; Drinking; Eating; Male; Naltrexone; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, kappa; Recurrence; Self Administration | 2000 |
Characterization of opioid receptors modulating neurogenic contractions of circular muscle from porcine ileum and evidence that delta- and kappa-opioid receptors are coexpressed in myenteric neurons.
Topics: Amino Acid Sequence; Animals; Electric Stimulation; Enkephalin, Leucine; Goats; Ileum; In Vitro Techniques; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Naltrexone; Rabbits; Receptors, Opioid, delta; Receptors, Opioid, kappa; Swine | 2001 |
Enadoline discrimination in squirrel monkeys: effects of opioid agonists and antagonists.
Topics: Animals; Benzofurans; Discrimination Learning; Dose-Response Relationship, Drug; Male; Nalbuphine; Naltrexone; Narcotic Antagonists; Pyrroles; Pyrrolidines; Receptors, Opioid, kappa; Receptors, Opioid, mu; Saimiri; Thiophenes | 2001 |
The novel kappa-opioid receptor agonist TRK-820 suppresses the rewarding and locomotor-enhancing effects of morphine in mice.
Topics: Animals; Dose-Response Relationship, Drug; Male; Mice; Morphinans; Morphine; Motor Activity; Naltrexone; Narcotics; Receptors, Opioid, kappa; Reward; Spiro Compounds | 2001 |
Ultrasonic vocalizations of preweanling rats: involvement of both alpha(2)-adrenoceptor and kappa-opioid receptor systems.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics, Non-Narcotic; Animals; Animals, Newborn; Animals, Suckling; Clonidine; Female; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Opioid, kappa; Vocalization, Animal; Yohimbine | 2001 |
The role of minoxidil on endogenous opioid peptides in the spinal cord: a putative co-agonist relationship between K-ATP openers and opioids.
Topics: Adenosine Triphosphate; Animals; Dose-Response Relationship, Drug; Male; Minoxidil; Naltrexone; Narcotic Antagonists; Nociceptors; Opioid Peptides; Pain; Potassium Channels; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Spinal Cord; Vasodilator Agents | 2001 |
Opioids suppress basal and nicotine-induced catecholamine secretion via a stabilizing effect on actin filaments.
Topics: Actins; Animals; Benzeneacetamides; Cytochalasin B; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Humans; Naltrexone; Narcotics; Nicotine; Norepinephrine; PC12 Cells; Pyrrolidines; Rats | 2001 |
TRK-820, a selective kappa-opioid agonist, produces potent antinociception in cynomolgus monkeys.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Behavior, Animal; Macaca fascicularis; Morphinans; Morphine; Naloxone; Naltrexone; Pain Measurement; Pentazocine; Pentobarbital; Receptors, Opioid, kappa; Spiro Compounds | 2001 |
Norbinaltorphimine, a selective kappa-opioid receptor antagonist, induces an itch-associated response in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Antipruritics; Behavior, Animal; Chlorpheniramine; Dose-Response Relationship, Drug; Histamine H1 Antagonists; Injections, Subcutaneous; Mice; Mice, Inbred ICR; Naltrexone; p-Methoxy-N-methylphenethylamine; Pruritus; Receptors, Opioid, kappa | 2001 |
Pharmacological characterization of the dermorphin analog [Dmt(1)]DALDA, a highly potent and selective mu-opioid peptide.
Topics: Analgesics; Animals; Drug Tolerance; Humans; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Oligodeoxyribonucleotides, Antisense; Oligopeptides; Opioid Peptides; Pain Measurement; Receptors, Opioid, mu; Time Factors | 2001 |
Endomorphins 1 and 2, endogenous mu-opioid receptor agonists, impair passive avoidance learning in mice.
Topics: Analgesics, Opioid; Animals; Avoidance Learning; Behavior, Animal; Dose-Response Relationship, Drug; Male; Mice; Naltrexone; Narcotic Antagonists; Oligopeptides; Receptors, Opioid, mu | 2001 |
Inducible HSP70 mediates delayed cardioprotection via U-50488H pretreatment in rat ventricular myocytes.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Heart; Heart Ventricles; HSP70 Heat-Shock Proteins; Ischemic Preconditioning, Myocardial; L-Lactate Dehydrogenase; Male; Myocardial Ischemia; Myocardium; Naltrexone; Narcotic Antagonists; Oligonucleotides, Antisense; Protective Agents; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa | 2001 |
From models to molecules: opioid receptor dimers, bivalent ligands, and selective opioid receptor probes.
Topics: Amino Acid Sequence; Binding Sites; Dimerization; Dynorphins; Ligands; Models, Molecular; Molecular Sequence Data; Naltrexone; Narcotic Antagonists; Protein Structure, Secondary; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Structure-Activity Relationship | 2001 |
Kappa opioid agonist-induced changes in IOP: correlation with 3H-NE release and cAMP accumulation.
Topics: Analysis of Variance; Animals; Ciliary Body; Cyclic AMP; Dose-Response Relationship, Drug; Electric Stimulation; Intraocular Pressure; Male; Naltrexone; Norepinephrine; Pupil; Pyrrolidines; Rabbits; Radioimmunoassay; Receptors, Opioid, kappa | 2001 |
Analgesic and antiinflammatory effects of two novel kappa-opioid peptides.
Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzeneacetamides; Dose-Response Relationship, Drug; Inflammation; Injections, Spinal; Male; Naloxone; Naltrexone; Narcotic Antagonists; Opioid Peptides; Pain Threshold; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, kappa | 2001 |
Rostral ventrolateral medullary opioid receptor subtypes in the inhibitory effect of electroacupuncture on reflex autonomic response in cats.
Topics: Animals; Autonomic Nervous System; Cats; Electroacupuncture; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Gallbladder; Medulla Oblongata; Microinjections; Naltrexone; Narcotic Antagonists; Neural Inhibition; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reflex; Somatostatin | 2001 |
Biphasic alterations of cAMP levels and inhibition of norepinephrine release in iris-ciliary body by bremazocine.
Topics: Adenylate Cyclase Toxin; Analgesics; Animals; Benzomorphans; Ciliary Body; Cyclic AMP; Iris; Male; Naltrexone; Narcotic Antagonists; Neuromuscular Junction; Norepinephrine; Pertussis Toxin; Rabbits; Receptors, Opioid, kappa; Sympathetic Nervous System; Virulence Factors, Bordetella | 2001 |
GR89,696: a potent kappa-opioid agonist with subtype selectivity in rhesus monkeys.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Benzeneacetamides; Cerebral Cortex; Discrimination, Psychological; Diuresis; Ethylketocyclazocine; Female; Guanosine 5'-O-(3-Thiotriphosphate); Macaca mulatta; Male; Membranes; Muscle Relaxation; Naltrexone; Pain Measurement; Piperazines; Prolactin; Pyrrolidines; Radioligand Assay; Receptors, Opioid, kappa; Respiratory Mechanics | 2001 |
Effects of endomorphin-2 on arterial blood pressure and pain threshold in spontaneously hypertensive rats and modification of these effects by beta-funaltrexamine and nor-binaltorphimine.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Blood Pressure; Disease Models, Animal; Drug Interactions; Male; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain; Pain Threshold; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 2001 |
Mu- and delta-opioid receptor antagonists reduce levodopa-induced dyskinesia in the MPTP-lesioned primate model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Callithrix; Disease Models, Animal; Drug Therapy, Combination; Dyskinesias; Female; Hypokinesia; Levodopa; Male; Morphinans; Motor Activity; Naltrexone; Narcotic Antagonists; Parkinsonian Disorders; Posture; Receptors, Opioid, delta; Receptors, Opioid, mu | 2001 |
Kappa-opioid receptors on lymphocytes of a human lymphocytic cell line: morphine-induced up-regulation as evidenced by competitive RT-PCR and indirect immunofluorescence.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Cell Line; Fluorescent Antibody Technique, Indirect; Humans; Lymphocytes; Morphine; Naltrexone; Narcotic Antagonists; Receptors, Opioid, kappa; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Up-Regulation | 2001 |
Differential antinociceptive effects induced by intrathecally administered endomorphin-1 and endomorphin-2 in the mouse.
Topics: Analgesics; Animals; Benzylidene Compounds; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Methionine; Immune Sera; Injections, Spinal; Injections, Subcutaneous; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain; Pain Measurement; Pain Threshold; Peptide Fragments; Time Factors | 2001 |
Administration of mu-, kappa- or delta2-receptor agonists via osmotic minipumps suppresses murine splenic antibody responses.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Antibody Formation; Depression, Chemical; Dose-Response Relationship, Drug; Female; Immunosuppressive Agents; Infusion Pumps; Mice; Mice, Inbred C3H; Morphine; Naltrexone; Neuroimmunomodulation; Oligopeptides; Osmosis; Peptide Fragments; Peptides; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin; Spleen | 2001 |
The effect of the leucopyrokinin analogue: [2-8]-leucopyrokinin on central opioid receptors in rats.
Topics: Analgesia; Analgesics; Animals; Dose-Response Relationship, Drug; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Oligopeptides; Peptide Fragments; Rats; Rats, Wistar; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tail; Time Factors | 2001 |
Morphine upregulates kappa-opioid receptors of human lymphocytes.
Topics: Animals; Cell Line; Humans; Hybrid Cells; Immunosuppressive Agents; Lymphocytes; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, kappa; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Up-Regulation | 2001 |
Comparison of the peripheral and central effects of the opioid agonists loperamide and morphine in the formalin test in rats.
Topics: Analgesics, Opioid; Animals; Antidiarrheals; Cisterna Magna; Dose-Response Relationship, Drug; Formaldehyde; Injections; Injections, Subcutaneous; Loperamide; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2002 |
Antipruritic activity of the kappa-opioid receptor agonist, TRK-820.
Topics: Animals; Antipruritics; Chlorpheniramine; Disease Models, Animal; Histamine; Histamine H1 Antagonists; Ketotifen; Male; Mice; Mice, Inbred ICR; Morphinans; Motor Activity; Naltrexone; Pruritus; Receptors, Opioid, kappa; Spiro Compounds; Substance P | 2002 |
Analysis of opioid receptor subtype antagonist effects upon mu opioid agonist-induced feeding elicited from the ventral tegmental area of rats.
Topics: Animals; Appetite Regulation; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Feeding Behavior; Male; Naltrexone; Narcotic Antagonists; Narcotics; Neural Pathways; Neurons; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Synaptic Transmission; Ventral Tegmental Area | 2002 |
Dynorphin A(1-17)-induced feeding: pharmacological characterization using selective opioid antagonists and antisense probes in rats.
Topics: Animals; Dose-Response Relationship, Drug; Drug Interactions; Dynorphins; Feeding Behavior; Male; Models, Animal; Naltrexone; Narcotic Antagonists; Oligonucleotides, Antisense; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2002 |
Inhibition of cAMP accumulation by kappa-receptor activation in isolated iris-ciliary bodies: role of phosphodiesterase and protein kinase C.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Alkaloids; Animals; Benzophenanthridines; Ciliary Body; Colforsin; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; In Vitro Techniques; Iris; Naltrexone; Narcotic Antagonists; Phenanthridines; Phorbol 12,13-Dibutyrate; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperidines; Protein Kinase C; Pyrrolidines; Rabbits; Receptors, Opioid, kappa; Rolipram | 2002 |
Crystal structure of biphalin sulfate: a multireceptor opioid peptide.
Topics: Binding Sites; Crystallography, X-Ray; Enkephalin, Leucine-2-Alanine; Enkephalins; Hydrogen Bonding; Naltrexone; Narcotics; Oligopeptides; Pliability; Protein Conformation; Protein Folding; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship; Substrate Specificity; Tetrahydroisoquinolines | 2002 |
Motivational effects mu- and kappa-opioid agonists following acute and chronic restraint stress: involvement of dopamine D(1) and D(2) receptors.
Topics: Acute Disease; Animals; Behavior, Animal; Benzomorphans; Chronic Disease; Conditioning, Operant; Injections, Intraventricular; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stress, Psychological | 2002 |
Delta opioid inhibition of light-induced phase advances in hamster circadian activity rhythms.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzamides; Biological Clocks; Circadian Rhythm; Cricetinae; Enkephalins; Light; Male; Mesocricetus; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Nerve Tissue Proteins; Opioid Peptides; Piperazines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Suprachiasmatic Nucleus | 2002 |
Anti-nociceptive effect of neuropeptide Y in the nucleus accumbens of rats: an involvement of opioid receptors in the effect.
Topics: Animals; Catheterization; Dose-Response Relationship, Drug; Hot Temperature; Male; Microinjections; Naloxone; Naltrexone; Narcotic Antagonists; Neuropeptide Y; Nucleus Accumbens; Pain Measurement; Peptide Fragments; Physical Stimulation; Rats; Rats, Wistar; Receptors, Neuropeptide Y; Receptors, Opioid | 2002 |
The neuropeptide FF analogue, 1DMe, reduces in vivo dynorphin release from the rat spinal cord.
Topics: Animals; Dose-Response Relationship, Drug; Dynorphins; Injections, Spinal; Male; Models, Animal; Naltrexone; Narcotic Antagonists; Oligopeptides; Peptide Fragments; Perfusion; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin; Spinal Cord | 2002 |
Blockade of nigral and pallidal opioid receptors suppresses vacuous chewing movements in a rodent model of tardive dyskinesia.
Topics: Animals; Dose-Response Relationship, Drug; Dynorphins; Dyskinesia, Drug-Induced; Fluphenazine; Globus Pallidus; Male; Mastication; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Somatostatin; Substantia Nigra | 2002 |
Involvement of endogenous opioid systems in nociceptin-induced spinal antinociception in rats.
Topics: Animals; Endorphins; Hindlimb; Hot Temperature; Injections, Spinal; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptin; Nociceptors; Opioid Peptides; Pain; Pain Measurement; Peptide Fragments; Physical Stimulation; Rats; Rats, Sprague-Dawley; Spinal Cord | 2002 |
Possible involvement of mu1-opioid receptors in the fentanyl- or morphine-induced antinociception at supraspinal and spinal sites.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Fentanyl; Injections, Intraventricular; Injections, Spinal; Injections, Subcutaneous; Male; Mice; Mice, Inbred C57BL; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Receptors, Opioid, mu; Spinal Cord | 2002 |
Effects of opioid antagonists on unconditioned and conditioned hyperactivity to morphine.
Topics: Analgesics, Opioid; Animals; Conditioning, Operant; Dose-Response Relationship, Drug; Hyperkinesis; Male; Morphine; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2002 |
Expression of functional kappa-opioid receptors on murine dendritic cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Antigen Presentation; Dendritic Cells; Dynorphins; Gene Expression; Histocompatibility Antigens Class II; In Vitro Techniques; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Naltrexone; Narcotic Antagonists; Neuroimmunomodulation; Phenotype; Receptors, Opioid, kappa; RNA, Messenger | 2002 |
Effect of prodynorphin-derived opioid peptides on the ovulatory luteinizing hormone surge in the proestrous rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Brain; Dynorphins; Enkephalins; Female; Luteinizing Hormone; Naltrexone; Ovulation; Peptide Fragments; Proestrus; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa | 2002 |
The effect of opioid antagonism on food intake behavior and body weight in a biobehavioral model of obese binge eating.
Topics: Animals; Body Weight; Brain; Bulimia; Energy Intake; Feeding Behavior; Hyperphagia; Injections, Intraventricular; Models, Animal; Naltrexone; Narcotic Antagonists; Obesity; Rats; Rats, Zucker; Satiation | 2002 |
Involvement of the opioid system in the anxiolytic-like effects induced by Delta(9)-tetrahydrocannabinol.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Darkness; Dronabinol; Endorphins; Light; Male; Mice; Naltrexone; Narcotic Antagonists; Piperidines; Pyrazoles; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Rimonabant | 2002 |
Lack of the nociceptin receptor does not affect acute or chronic nociception in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Female; Male; Mice; Mice, Knockout; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptin; Nociceptin Receptor; Oligopeptides; Opioid Peptides; Pain; Receptors, Opioid; Time Factors; Vas Deferens | 2002 |
Different effects of methionine-enkephalin on paw edema in two inbred rat strains.
Topics: Animals; Dexamethasone; Dose-Response Relationship, Drug; Edema; Enkephalin, Methionine; Glucocorticoids; Inflammation; Kinetics; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Species Specificity; Time Factors | 2002 |
Relationship between NOC/oFQ, dynorphin, and COX-2 activation in impaired NMDA cerebrovasodilation after brain injury.
Topics: Animals; Animals, Newborn; Brain Injuries; Cyclooxygenase 2; Dynorphins; Enzyme Activation; Female; Glutamic Acid; Indomethacin; Isoenzymes; Male; N-Methylaspartate; Naltrexone; Nitrobenzenes; Nociceptin; Opioid Peptides; Pia Mater; Prostaglandin-Endoperoxide Synthases; Sulfonamides; Superoxides; Swine; Vasodilation | 2002 |
Pharmacology of opioid inhibition to noxious uterine cervical distension.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Cervix Uteri; Dose-Response Relationship, Drug; Electromyography; Female; Hemodynamics; Morphine; Naltrexone; Narcotic Antagonists; Ovariectomy; Pain Threshold; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Uterus | 2002 |
Kappa opioid antagonist effects of the novel kappa antagonist 5'-guanidinonaltrindole (GNTI) in an assay of schedule-controlled behavior in rhesus monkeys.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Non-Narcotic; Animals; Benzamides; Benzeneacetamides; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Interactions; Female; Guanidines; Macaca mulatta; Male; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Piperazines; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Reinforcement Schedule; Time Factors | 2002 |
Focal kappa-opioid receptor-mediated dependence and withdrawal in the nucleus paragigantocellularis.
Topics: Animals; Basal Ganglia; Butorphanol; Diffusion; Electric Stimulation; Male; Microinjections; Morphine; Morphine Dependence; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Stereotaxic Techniques; Stereotyped Behavior; Substance Withdrawal Syndrome | 2002 |
Combined blockade of both micro - and kappa-opioid receptors prevents the acute orexigenic action of Agouti-related protein.
Topics: Agouti-Related Protein; Animals; Drug Interactions; Eating; Male; Naltrexone; Narcotic Antagonists; Peptide Fragments; Rats; Rats, Long-Evans; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2002 |
Dynorphin-independent spinal cannabinoid antinociception.
Topics: Analgesics; Analgesics, Non-Narcotic; Animals; Benzoxazines; Dose-Response Relationship, Drug; Dronabinol; Dynorphins; Injections, Spinal; Male; Mice; Mice, Knockout; Morpholines; Naltrexone; Naphthalenes; Pain; Pain Measurement; Reference Values; Reproducibility of Results; Sensitivity and Specificity; Single-Blind Method; Species Specificity; Spinal Cord | 2002 |
U50,488 inhibits HIV-1 Tat-induced monocyte chemoattractant protein-1 (CCL2) production by human astrocytes.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Astrocytes; Cells, Cultured; Chemokine CCL2; Drug Interactions; Gene Products, tat; HIV-1; Humans; Naltrexone; Narcotic Antagonists; NF-kappa B; tat Gene Products, Human Immunodeficiency Virus | 2003 |
Functional interactions between delta- and mu-opioid receptors in rat thermoregulation.
Topics: Animals; Body Temperature; Body Temperature Regulation; Dose-Response Relationship, Drug; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptor Cross-Talk; Receptors, Opioid, delta; Receptors, Opioid, mu | 2003 |
[Repeated 100 Hz TENS for the treatment of chronic inflammatory pain in rats: optimal parameters and possible neuro-chemical mechanisms].
Topics: Animals; Arthralgia; Arthritis, Experimental; Chronic Disease; Dynorphins; Naltrexone; Pain Threshold; Rats; Substance P; Transcutaneous Electric Nerve Stimulation | 1999 |
Intraventricular insulin decreases kappa opioid-mediated sucrose intake in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Feeding Behavior; Injections, Intraventricular; Insulin; Male; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Receptors, Opioid, kappa; Sucrose | 2002 |
Inhibition of urinary bladder motility by a spinal action of U-50488H in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Area Under Curve; Dose-Response Relationship, Drug; Electric Stimulation; Injections, Intravenous; Injections, Spinal; Male; Methysergide; Muscle Contraction; Muscle, Smooth; Naltrexone; Pons; Rats; Rats, Wistar; Receptors, Opioid, kappa; Reserpine; Serotonin Antagonists; Stress, Mechanical; Urinary Bladder; Urination; Yohimbine | 2002 |
Role of kappa-opioid receptor activation in pharmacological preconditioning of swine.
Topics: Animals; Arrhythmias, Cardiac; Coronary Circulation; Enkephalin, Leucine-2-Alanine; Hemodynamics; Ischemic Preconditioning, Myocardial; Morphine; Myocardial Infarction; Myocardial Ischemia; Naltrexone; Narcotic Antagonists; Narcotics; Pentazocine; Receptors, Opioid, kappa; Swine | 2003 |
Opioid receptor antagonists modulate Ca2+-activated K+ channels in mesenteric arterial smooth muscle cells of rats in hemorrhagic shock.
Topics: Animals; Calcium; Dose-Response Relationship, Drug; Down-Regulation; Electrophysiology; Kinetics; Membrane Potentials; Mesenteric Arteries; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Naloxone; Naltrexone; Narcotic Antagonists; Potassium Channels; Rats; Rats, Wistar; Shock, Hemorrhagic | 2003 |
Blockade of mu-opioid receptor-mediated G-protein activation and antinociception by TRK-820 in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; GTP-Binding Proteins; In Vitro Techniques; Injections, Intraventricular; Medulla Oblongata; Mice; Morphinans; Naltrexone; Narcotic Antagonists; Pain Measurement; Pons; Radioligand Assay; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spiro Compounds | 2003 |
Opioid receptor subtypes involved in the regulation of prolactin secretion during pregnancy and lactation.
Topics: Animals; Female; Injections, Intraventricular; Lactation; Naltrexone; Narcotic Antagonists; Pituitary Gland; Pregnancy; Pregnancy, Animal; Prolactin; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2003 |
Modulation of myofilament Ca2+ densitivity by delta- and kappa-opioid agonists in intact guinea pig hearts.
Topics: Actin Cytoskeleton; Animals; Benzylidene Compounds; Blood Pressure; Calcium; Coronary Circulation; Guinea Pigs; Heart; Heart Rate; In Vitro Techniques; Kinetics; Naltrexone; Narcotic Antagonists; Pyrrolidines; Quinolines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Stimulation, Chemical; Ventricular Function, Left | 2003 |
Endogenous opioid peptides contribute to antinociceptive potency of intrathecal [Dmt1]DALDA.
Topics: Analgesics, Opioid; Animals; Antibodies, Blocking; Cloning, Molecular; Dynorphins; Endorphins; Enkephalin, Methionine; Guanosine 5'-O-(3-Thiotriphosphate); Hot Temperature; Injections, Intraventricular; Injections, Spinal; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain Measurement; Radioligand Assay; Reaction Time; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2003 |
Activation of kappa-opioid receptors inhibits pruritus evoked by subcutaneous or intrathecal administration of morphine in monkeys.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Disease Models, Animal; Drug Interactions; Female; Injections, Spinal; Injections, Subcutaneous; Macaca mulatta; Male; Morphine; Naltrexone; Narcotic Antagonists; Pruritus; Receptors, Opioid, kappa | 2003 |
Effect of opioid receptor antagonists on hypothalamic-pituitary-adrenal activity in rhesus monkeys.
Topics: Adrenocorticotropic Hormone; Animals; Cinnamates; Dose-Response Relationship, Drug; Female; Hydrocortisone; Hypothalamo-Hypophyseal System; Macaca mulatta; Male; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Pituitary-Adrenal System | 2003 |
Behavioral and neuroendocrine actions of the Met-enkephalin-related peptide MERF.
Topics: Analysis of Variance; Animals; Behavior, Animal; Corticotropin-Releasing Hormone; Dopamine; Enkephalin, Methionine; Exploratory Behavior; Haloperidol; Hormone Antagonists; Hypothalamo-Hypophyseal System; Male; Mice; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Neostriatum; Organ Culture Techniques; Peptide Fragments; Pituitary-Adrenal System | 2003 |
The antitussive effects of endomorphin-1 and endomorphin-2 in mice.
Topics: Animals; Antitussive Agents; Capsaicin; Cough; Dose-Response Relationship, Drug; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Oligopeptides; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2003 |
Identity of the putative delta1-opioid receptor as a delta-kappa heteromer in the mouse spinal cord.
Topics: Animals; Benzylidene Compounds; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Immune Sera; Mice; Naltrexone; Oligopeptides; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin; Spinal Cord | 2003 |
Interleukin-2 increases activity of sarcoplasmic reticulum Ca2+-ATPase, but decreases its sensitivity to calcium in rat cardiomyocytes.
Topics: Adenosine Triphosphate; Animals; Biological Transport; Caffeine; Calcium; Calcium Channels, L-Type; Calcium-Transporting ATPases; Cyclic AMP; Heart; Interleukin-2; Male; Myocardium; Myocytes, Cardiac; Naltrexone; Rats; Rats, Sprague-Dawley; Sarcoplasmic Reticulum | 2003 |
Blockade of dorsal hippocampal kappa-opioid receptors increases blood pressure in normotensive and isolation-induced hypertensive rats.
Topics: Anesthesia; Animals; Blood Pressure; Body Weight; Heart Rate; Hippocampus; Hypertension; Male; Microinjections; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Social Isolation; Stress, Psychological | 2003 |
Agonist/antagonist properties of nalbuphine, butorphanol and (-)-pentazocine in male vs. female rats.
Topics: Animals; Benzeneacetamides; Butorphanol; Diuresis; Diuretics; Dose-Response Relationship, Drug; Female; Male; Nalbuphine; Naltrexone; Narcotic Antagonists; Pentazocine; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sex Characteristics; Urination | 2003 |
Enhanced binding of nor-binaltorphimine to kappa-opioid receptors in rats dependent on butorphanol.
Topics: Animals; Brain; Butorphanol; Dose-Response Relationship, Drug; Male; Naltrexone; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Substance Withdrawal Syndrome; Substance-Related Disorders | 2003 |
Morphine withdrawal precipitated by specific mu, delta or kappa opioid receptor antagonists: a c-Fos protein study in the rat central nervous system.
Topics: Animals; Behavior, Animal; Cell Count; Central Nervous System; Gene Expression Regulation; Immunohistochemistry; Male; Morphine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Narcotics; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 2003 |
Sialorphin, a natural inhibitor of rat membrane-bound neutral endopeptidase that displays analgesic activity.
Topics: Amino Acid Sequence; Analgesics; Animals; Enkephalin, Methionine; Formaldehyde; Glycopeptides; Kidney; Leucine; Male; Membrane Proteins; Molecular Sequence Data; Naltrexone; Neprilysin; Pain; Pain Measurement; Prostate; Protease Inhibitors; Protein Precursors; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Salivary Proteins and Peptides; Spinal Cord; Submandibular Gland; Substance P; Thiorphan; Wounds and Injuries | 2003 |
Kappa opioid receptor antagonism and prodynorphin gene disruption block stress-induced behavioral responses.
Topics: Analgesia; Animals; Behavior, Animal; Cocaine; Drug Synergism; Enkephalins; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Naltrexone; Narcotic Antagonists; Pain Threshold; Protein Precursors; Reaction Time; Receptors, Opioid, kappa; Reward; Spatial Behavior; Stress, Physiological; Swimming | 2003 |
Presence of kappa-opioid tone at the onset of the ovulatory luteinizing hormone surge in the proestrous rat.
Topics: Animals; Brain; Female; Luteinizing Hormone; Naltrexone; Narcotic Antagonists; Proestrus; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa | 2003 |
Effects of U50,488H on transient outward and ultra-rapid delayed rectifier K+ currents in young human atrial myocytes.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adolescent; Child; Child, Preschool; Delayed Rectifier Potassium Channels; Female; Heart Atria; Humans; Infant; Male; Myocytes, Cardiac; Naloxone; Naltrexone; Narcotic Antagonists; Patch-Clamp Techniques; Potassium Channels; Potassium Channels, Tandem Pore Domain; Potassium Channels, Voltage-Gated; Receptors, Opioid, kappa | 2003 |
Antinociceptive properties of oxymorphazole in the mouse.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Injections, Spinal; Male; Mice; Morpholines; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Receptors, Opioid, delta; Receptors, Opioid, mu; Somatostatin; Time Factors | 2003 |
Involvement of oxytocin in spinal antinociception in rats with inflammation.
Topics: Analgesics; Animals; Carrageenan; Hot Temperature; Inflammation; Injections, Spinal; Male; Naloxone; Naltrexone; Narcotic Antagonists; Oxytocin; Pain; Pain Measurement; Physical Stimulation; Rats; Rats, Wistar; Spinal Cord; Vasotocin | 2003 |
Ultra-long antagonism of kappa opioid agonist-induced diuresis by intracisternal nor-binaltorphimine in monkeys.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Diuresis; Female; Injections, Intraventricular; Macaca mulatta; Male; Naltrexone; Narcotic Antagonists; Receptors, Opioid, kappa | 2003 |
kappa-Opioid withdrawal in Planaria.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adaptation, Physiological; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Hydrogen-Ion Concentration; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Osmolar Concentration; Planarians; Reaction Time; Receptors, Opioid, kappa; Substance Withdrawal Syndrome | 2003 |
Involvement of central mu-opioid system in the scratching behavior in mice, and the suppression of it by the activation of kappa-opioid system.
Topics: Animals; Antipruritics; Behavior, Animal; Injections, Intraventricular; Injections, Subcutaneous; Ketotifen; Male; Mice; Morphinans; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Pruritus; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spiro Compounds; Substance P | 2003 |
Roles of KATP channels in delayed cardioprotection and intracellular Ca(2+) in the rat heart as revealed by kappa-opioid receptor stimulation with U50488H.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Calcium; Calcium Signaling; Coronary Circulation; Coronary Vessels; Dose-Response Relationship, Drug; Heart; Heart Rate; Injections, Intravenous; Ischemic Preconditioning, Myocardial; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocytes, Cardiac; Naltrexone; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Time Factors | 2003 |
Prolonged kappa opioid receptor phosphorylation mediated by G-protein receptor kinase underlies sustained analgesic tolerance.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Cell Line; Drug Tolerance; G-Protein-Coupled Receptor Kinase 3; Humans; Mice; Mice, Inbred C57BL; Mice, Knockout; Naltrexone; Phosphorylation; Protein Serine-Threonine Kinases; Receptors, Opioid, kappa | 2004 |
Nonopioid receptor-mediated effects of U-50,488H on [Ca(2+)]i and extracellular dopamine in PC12 cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; 3,4-Dihydroxyphenylacetic Acid; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Calcium; Dopamine; Dose-Response Relationship, Drug; Intracellular Fluid; Naltrexone; Narcotic Antagonists; PC12 Cells; Rats; Receptors, Opioid, kappa | 2003 |
Kappa-opioid agonists directly inhibit midbrain dopaminergic neurons.
Topics: Analgesics; Animals; Benzeneacetamides; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; In Vitro Techniques; Male; Mesencephalon; Naltrexone; Narcotic Antagonists; Neural Inhibition; Neurons; Patch-Clamp Techniques; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Ventral Tegmental Area | 2003 |
Reassessment of buprenorphine in conditioned place preference: temporal and pharmacological considerations.
Topics: Animals; Buprenorphine; Conditioning, Operant; Dose-Response Relationship, Drug; Male; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Nociceptin Receptor; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, kappa; Time Factors | 2004 |
Neuroanatomical and neuropharmacological study of opioid pathways in the mesencephalic tectum: effect of mu(1)- and kappa-opioid receptor blockade on escape behavior induced by electrical stimulation of the inferior colliculus.
Topics: Animals; Biotin; Dextrans; Dose-Response Relationship, Drug; Electric Stimulation; Escape Reaction; Fear; Inferior Colliculi; Male; Naloxone; Naltrexone; Narcotic Antagonists; Neural Pathways; Opioid Peptides; Periaqueductal Gray; Presynaptic Terminals; Rats; Rats, Wistar; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2003 |
Kappa-opioid receptor selectivity for ischemic neuroprotection with BRL 52537 in rats.
Topics: Animals; Behavior, Animal; Cerebral Cortex; Cranial Nerves; Functional Laterality; Gait; Hemodynamics; Ischemic Attack, Transient; Laser-Doppler Flowmetry; Male; Middle Cerebral Artery; Muscle Tonus; Naltrexone; Neuroprotective Agents; Pain; Piperidines; Putamen; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, kappa; Weight Loss | 2003 |
Opioid-mediated modulation of calcium currents in striatal and pallidal neurons following reserpine treatment: focus on kappa response.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic Uptake Inhibitors; Alkaloids; Analgesics, Non-Narcotic; Analgesics, Opioid; Analysis of Variance; Animals; Benzophenanthridines; Calcium Channel Blockers; Calcium Channels; Cell Size; Cells, Cultured; Corpus Striatum; Dose-Response Relationship, Drug; Drug Interactions; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enzyme Inhibitors; Male; Membrane Potentials; Naltrexone; Narcotic Antagonists; Neural Inhibition; Neurons; omega-Conotoxin GVIA; Patch-Clamp Techniques; Phenanthridines; Rats; Rats, Wistar; Receptors, Opioid, kappa; Reserpine | 2004 |
Differential antinociceptive effects of L-arginine and 3-morpholinosydoimine.
Topics: Analgesics; Animals; Arginine; Dose-Response Relationship, Drug; Dynorphins; Injections, Intraventricular; Male; Mice; Molsidomine; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement | 2003 |
Effect of the kappa opioid agonist R-84760 on cocaine-induced increases in striatal dopamine levels and cocaine-induced place preference in C57BL/6J mice.
Topics: Analysis of Variance; Animals; Behavior, Animal; Chromatography, High Pressure Liquid; Cocaine; Conditioning, Operant; Dopamine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Food; Male; Mice; Mice, Inbred C57BL; Microdialysis; Motor Activity; Naltrexone; Narcotic Antagonists; Neostriatum; Pyrrolidines; Receptors, Opioid, kappa; Thiazines | 2004 |
Region-dependent G-protein activation by kappa-opioid receptor agonists in the mouse brain.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzeneacetamides; Brain; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice; Morphinans; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid, kappa; Spiro Compounds | 2004 |
Importance of phenolic address groups in opioid kappa receptor selective antagonists.
Topics: Animals; Binding, Competitive; Brain; In Vitro Techniques; Naltrexone; Phenols; Piperidines; Radioligand Assay; Rats; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship; Tetrahydroisoquinolines | 2004 |
Temporal dissociation of the feedback effects of dendritically co-released peptides on rhythmogenesis in vasopressin cells.
Topics: Action Potentials; Animals; Antidiuretic Hormone Receptor Antagonists; Dendrites; Dynorphins; Feedback, Physiological; Female; Naltrexone; Narcotic Antagonists; Periodicity; Piperidines; Quinolones; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Supraoptic Nucleus; Vasopressins | 2004 |
Nonopioidergic mechanism mediating morphine-induced antianalgesia in the mouse spinal cord.
Topics: Analgesia; Animals; beta-Endorphin; Dizocilpine Maleate; Drug Interactions; Drug Tolerance; Dynorphins; Enkephalins; Male; Mice; Morphine; Naloxone; Naltrexone; Oligopeptides; Pain; Pain Measurement; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord; Substance P | 2004 |
Opioid receptor antagonists increase [Ca2+]i in rat arterial smooth muscle cells in hemorrhagic shock.
Topics: Animals; Calcium; Cell Separation; Mesenteric Arteries; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Shock, Hemorrhagic | 2004 |
Supraspinal and spinal cord opioid receptors are responsible for antinociception following intrathecal morphine injections.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Injections, Spinal; Male; Models, Animal; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Pain; Pain Threshold; Random Allocation; Rats; Rats, Wistar; Reaction Time; Receptors, Opioid; Spinal Cord; Tail | 2004 |
Relative contribution of endogenous opioids to myocardial ischemic tolerance.
Topics: Animals; Dynorphins; Endorphins; Enkephalin, Methionine; In Vitro Techniques; Ischemic Preconditioning, Myocardial; Naltrexone; Narcotic Antagonists; Rabbits; Receptors, Opioid, delta; Receptors, Opioid, kappa; Recovery of Function; Ventricular Function, Left | 2004 |
Effects of the kappa opioid agonist U50,488 and the kappa opioid antagonist nor-binaltorphimine on choice between cocaine and food in rhesus monkeys.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Behavior, Addictive; Choice Behavior; Cocaine; Dose-Response Relationship, Drug; Eating; Macaca mulatta; Male; Naltrexone; Receptors, Opioid, kappa | 2004 |
Mu opioid modulation of oxytocin secretion in late pregnant and parturient rats. Involvement of noradrenergic neurotransmission.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Cinnamates; Enzyme-Linked Immunosorbent Assay; Estrogens; Female; Methoxyhydroxyphenylglycol; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Narcotics; Norepinephrine; Oxytocin; Paraventricular Hypothalamic Nucleus; Pregnancy; Progesterone; Rats; Rats, Wistar; Receptors, Opioid, kappa; Receptors, Opioid, mu; Supraoptic Nucleus | 2004 |
Involvement of opioid receptors in the oxytocin-induced antinociception in the central nervous system of rats.
Topics: Animals; Central Nervous System; Male; Naloxone; Naltrexone; Narcotic Antagonists; Oxytocin; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2004 |
Instrumental learning within the spinal cord: III. Prior exposure to noncontingent shock induces a behavioral deficit that is blocked by an opioid antagonist.
Topics: Analysis of Variance; Animals; Association Learning; Conditioning, Operant; Electroshock; Hindlimb; Injections, Intravenous; Injections, Spinal; Male; Naltrexone; Narcotic Antagonists; Practice, Psychological; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Spinal Cord | 2004 |
The antinociceptive effect of Delta9-tetrahydrocannabinol in the arthritic rat.
Topics: Animals; Arthritis, Experimental; Cannabinoid Receptor Antagonists; Dose-Response Relationship, Drug; Dronabinol; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Freund's Adjuvant; Injections, Intradermal; Injections, Intraperitoneal; Male; Morphine; Mycobacterium; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Opioid; Rimonabant | 2004 |
Study of the involvement of K+ channels in the peripheral antinociception of the kappa-opioid receptor agonist bremazocine.
Topics: 4-Aminopyridine; Analgesics; Animals; ATP-Binding Cassette Transporters; Benzomorphans; Charybdotoxin; Cyclic GMP; Dequalinium; Glyburide; Hyperalgesia; KATP Channels; Male; Naltrexone; Nitric Oxide; Peripheral Nervous System; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Rats, Wistar; Receptors, Opioid, kappa; Signal Transduction; Tetraethylammonium; Tolbutamide | 2004 |
Direct evidence for the involvement of the mesolimbic kappa-opioid system in the morphine-induced rewarding effect under an inflammatory pain-like state.
Topics: Animals; Brain Chemistry; Conditioning, Operant; Dopamine; Dynorphins; Edema; Foot; Formaldehyde; Inflammation; Limbic System; Male; Microdialysis; Microinjections; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reward | 2005 |
Stress increases dynorphin immunoreactivity in limbic brain regions and dynorphin antagonism produces antidepressant-like effects.
Topics: Animals; Behavior, Animal; Cell Count; Disease Models, Animal; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Escape Reaction; Helplessness, Learned; Immobilization; Immunohistochemistry; Limbic System; Male; Naltrexone; Rats; Rats, Sprague-Dawley; Stress, Physiological | 2004 |
Opioid receptors and acetaminophen (paracetamol).
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Dynorphins; Endorphins; Enkephalins; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2004 |
Sexual dimorphism in the antinociception mediated by kappa opioid receptors in the rat temporomandibular joint.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Dose-Response Relationship, Drug; Estrous Cycle; Female; Formaldehyde; Male; Naltrexone; Pain Measurement; Rats; Rats, Wistar; Receptors, Opioid, kappa; Sex Characteristics; Temporomandibular Joint | 2004 |
A Tyr-W-MIF-1 analog containing D-Pro2 acts as a selective mu2-opioid receptor antagonist in the mouse.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Male; Mice; MSH Release-Inhibiting Hormone; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Receptors, Opioid, mu | 2005 |
Involvement of mu-, delta- and kappa-opioid receptor subtypes in the discriminative-stimulus effects of delta-9-tetrahydrocannabinol (THC) in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Benzamides; Conditioning, Operant; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Food; Hallucinogens; Heroin; Male; Naltrexone; Narcotic Antagonists; Narcotics; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reinforcement, Psychology | 2005 |
Peripheral effect of a kappa opioid receptor antagonist on nociception evoked by formalin injected in TMJ of pregnant rats.
Topics: Animals; Female; Formaldehyde; Naltrexone; Pain; Pregnancy; Pregnancy, Animal; Rats; Rats, Wistar; Receptors, Opioid, kappa; Temporomandibular Joint | 2005 |
Characterisation of opioid receptors involved in modulating circular and longitudinal muscle contraction in the rat ileum.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enteric Nervous System; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Muscle Contraction; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu | 2005 |
Major effect of pyrrolic N-benzylation in norbinaltorphimine, the selective kappa-opioid receptor antagonist.
Topics: Analgesics; Animals; Cell Line; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Mice; Naltrexone; Pyrroles; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship | 2005 |
Involvement of the opioid system in the effects induced by nicotine on anxiety-like behaviour in mice.
Topics: Analysis of Variance; Animals; Anxiety Disorders; Behavior, Animal; Dose-Response Relationship, Drug; Drug Antagonism; Drug Synergism; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Maze Learning; Mecamylamine; Mice; Naltrexone; Narcotic Antagonists; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Receptors, Opioid | 2005 |
Inhibitory control of the acute mu-withdrawal response by indirectly activated adenosine A1 and kappa-opioid systems in the Guinea-pig ileum; reversal by cholecystokinin.
Topics: Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Analgesics, Opioid; Animals; Cholecystokinin; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists; Opioid Peptides; Receptor, Adenosine A1; Receptors, Opioid, kappa; Receptors, Opioid, mu; Substance Withdrawal Syndrome; Theophylline | 2005 |
Kinin and opioid receptors in the paratrigeminal nucleus modulate the somatosensory reflex to rat sciatic nerve stimulation.
Topics: Animals; Arteries; Blood Pressure; Bradykinin; Bradykinin Receptor Antagonists; Electric Stimulation; Evoked Potentials, Somatosensory; Male; Models, Biological; Naltrexone; Narcotic Antagonists; Quinolines; Rats; Rats, Wistar; Receptors, Bradykinin; Receptors, Opioid; Reflex, Abnormal; Sciatic Nerve; Somatostatin; Trigeminal Nuclei | 2005 |
Kappa opioid receptor activation disrupts prepulse inhibition of the acoustic startle in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acoustic Stimulation; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Antipsychotic Agents; Apomorphine; Clozapine; Dizocilpine Maleate; Dopamine Agonists; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Excitatory Amino Acid Antagonists; Haloperidol; Inhibition, Psychological; Male; Naltrexone; Narcotic Antagonists; Rats; Receptors, Opioid, kappa; Reflex, Startle | 2005 |
Endogenous central kappa-opioid systems augment renal sympathetic nerve activity to maximally retain urinary sodium during hypotonic saline volume expansion.
Topics: Animals; Hypotonic Solutions; Kidney; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Sodium; Sodium Chloride; Sympathetic Nervous System; Time Factors | 2005 |
The kappa-opioid receptor is involved in the stimulating effect of nicotine on adrenocortical activity but not in nicotine induced anxiety.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Anxiety; Behavior, Animal; Corticosterone; Drug Interactions; Endocrine System; Male; Maze Learning; Naltrexone; Narcotic Antagonists; Nicotine; Nicotinic Agonists; Radioimmunoassay; Rats; Rats, Wistar; Receptors, Opioid, kappa | 2005 |
A single injection of the kappa opioid antagonist norbinaltorphimine increases ethanol consumption in rats.
Topics: Alcohol Drinking; Animals; Body Weight; Choice Behavior; Conditioning, Psychological; Drinking; Female; Male; Naltrexone; Rats; Rats, Inbred Lew; Receptors, Opioid, kappa; Sex Characteristics | 2005 |
In vitro electrophysiologic effects of morphine in rabbit ventricular myocytes.
Topics: Action Potentials; Animals; Calcium; Calcium Channels, L-Type; Female; In Vitro Techniques; Male; Morphine; Myocytes, Cardiac; Naltrexone; Potassium Channels; Rabbits | 2005 |
Social defeat stress-induced behavioral responses are mediated by the endogenous kappa opioid system.
Topics: Analysis of Variance; Anesthetics, Local; Animals; Behavior, Animal; Cocaine; Conditioning, Operant; Enkephalins; Immobility Response, Tonic; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Naltrexone; Narcotic Antagonists; Pain Measurement; Protein Precursors; Reaction Time; Receptors, Opioid, kappa; Social Behavior; Stress, Psychological | 2006 |
Improvement of memory impairment by (+)- and (-)-pentazocine via sigma, but not kappa opioid receptors.
Topics: Acetic Acid; Analgesics, Opioid; Analysis of Variance; Animals; Anisoles; Antipsychotic Agents; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Exploratory Behavior; Isomerism; Male; Maze Learning; Memory Disorders; Mice; Naltrexone; Narcotic Antagonists; Pain Measurement; Pentazocine; Propylamines; Receptors, Opioid, kappa; Receptors, sigma; Scopolamine | 2005 |
Antinociception, tolerance and withdrawal symptoms induced by 7-hydroxymitragynine, an alkaloid from the Thai medicinal herb Mitragyna speciosa.
Topics: Analgesics; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Injections, Subcutaneous; Male; Mice; Mitragyna; Models, Molecular; Morphinans; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Reaction Time; Secologanin Tryptamine Alkaloids; Substance Withdrawal Syndrome; Thailand | 2005 |
Pain-relieving effects of processed Aconiti tuber in CCI-neuropathic rats.
Topics: Aconitum; Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Injections, Intraperitoneal; Injections, Spinal; Male; Naltrexone; Pain Measurement; Pain Threshold; Plant Tubers; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Sciatic Nerve; Sciatica | 2006 |
Pharmacological study on the novel antinociceptive agent, a novel monoterpene alkaloid from Incarvillea sinensis.
Topics: Alkaloids; Analgesics; Bignoniaceae; Monoterpenes; Naltrexone; Narcotic Antagonists; Purinergic P1 Receptor Antagonists | 2005 |
Subclass opioid receptors associated with the cardiovascular depression after traumatic shock and the antishock effects of its specific receptor antagonists.
Topics: Animals; Blood Pressure; Cardiovascular System; Enkephalin, Leucine; Femur; Free Radicals; GABA Modulators; Hemodynamics; Models, Statistical; Naltrexone; Narcotic Antagonists; Pentobarbital; Rats; Rats, Wistar; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Shock; Time Factors | 2005 |
Coordinated and spatial upregulation of arc in striatonigral neurons correlates with L-dopa-induced behavioral sensitization in dyskinetic rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic Agents; AIDS-Related Complex; Amphetamine; Analgesics, Non-Narcotic; Animals; Antiparkinson Agents; Behavior, Animal; Carrier Proteins; Central Nervous System Stimulants; Corpus Striatum; Disease Models, Animal; Drug Interactions; Dynorphins; Dyskinesia, Drug-Induced; Functional Laterality; Homer Scaffolding Proteins; Immunohistochemistry; In Situ Hybridization; Levodopa; Male; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Oxidopamine; Protein Precursors; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Stereotyped Behavior; Substantia Nigra; Time Factors; Tyrosine 3-Monooxygenase; Up-Regulation | 2005 |
Antinociceptive effect of oxycodone in diabetic mice.
Topics: Analgesics, Opioid; Animals; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Narcotic Antagonists; Oxycodone; Pain; Pain Measurement; Time Factors | 2005 |
The dynamic relationship between mu and kappa opioid receptors in body temperature regulation.
Topics: Animals; Body Temperature Regulation; Dose-Response Relationship, Drug; Drug Antagonism; Dynorphins; Injections, Intraventricular; Male; Naltrexone; Narcotic Antagonists; Neurotransmitter Agents; Peptide Fragments; Peptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin | 2005 |
Effects of the local administration of selective mu-, delta-and kappa-opioid receptor agonists on osteosarcoma-induced hyperalgesia.
Topics: Analgesics, Opioid; Animals; Bone Neoplasms; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Hyperalgesia; Mice; Morphinans; Naltrexone; Narcotic Antagonists; Osteosarcoma; Receptors, Opioid | 2005 |
Kappa-opioid receptor-mediated effects of the plant-derived hallucinogen, salvinorin A, on inverted screen performance in the mouse.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Benzeneacetamides; Diterpenes; Diterpenes, Clerodane; Hallucinogens; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Piperidines; Psychotropic Drugs; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Remifentanil | 2005 |
Localization of opioid receptor antagonist [3H]-LY255582 binding sites in mouse brain: comparison with the distribution of mu, delta and kappa binding sites.
Topics: Animals; Autoradiography; Binding Sites; Brain; Cyclohexanes; Mice; Mice, Knockout; Molecular Structure; Naloxone; Naltrexone; Narcotic Antagonists; Piperidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tritium | 2005 |
Big dynorphin, a prodynorphin-derived peptide produces NMDA receptor-mediated effects on memory, anxiolytic-like and locomotor behavior in mice.
Topics: Amino Acid Sequence; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Dose-Response Relationship, Drug; Dynorphins; Enkephalins; Hot Temperature; Male; Memory; Mice; Molecular Sequence Data; Motor Activity; Naltrexone; Pain Measurement; Protein Precursors; Reaction Time; Receptors, N-Methyl-D-Aspartate | 2006 |
Involvement of kappa/dynorphin system in WIN 55,212-2 self-administration in mice.
Topics: Animals; Benzoxazines; Cannabinoids; Conditioning, Operant; Dose-Response Relationship, Drug; Dynorphins; Enkephalins; Male; Mice; Mice, Knockout; Morpholines; Naltrexone; Naphthalenes; Protein Precursors; Receptor, Cannabinoid, CB1; Receptors, Opioid, kappa; Self Administration | 2006 |
Dynorphin A (2-13) improves mecamylamine-induced learning impairment accompanied by reversal of reductions in acetylcholine release in rats.
Topics: Acetylcholine; Animals; Dynorphins; Functional Laterality; Hippocampus; Injections, Intraventricular; Learning; Learning Disabilities; Male; Mecamylamine; Microdialysis; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley | 2006 |
Antinociceptive effect of shakuyakukanzoto, a Kampo medicine, in diabetic mice.
Topics: Adrenergic alpha-Antagonists; Analgesics; Animals; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Drug Combinations; Drugs, Chinese Herbal; Glycyrrhiza; Male; Medicine, Kampo; Methysergide; Mice; Naltrexone; Narcotic Antagonists; Oxidopamine; Paeonia; Pain Measurement; Pain Threshold; Piperazines; Serotonin Antagonists; Sympatholytics; Tropanes; Yohimbine | 2005 |
Paradoxical effects of prodynorphin gene deletion on basal and cocaine-evoked dopaminergic neurotransmission in the nucleus accumbens.
Topics: Analgesics; Animals; Area Under Curve; Behavior, Animal; Benzeneacetamides; Chromatography, High Pressure Liquid; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Dynorphins; Electrochemistry; Mice; Mice, Inbred C57BL; Mice, Knockout; Microdialysis; Motor Activity; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Pyrrolidines | 2006 |
Antinociceptive profile of salvinorin A, a structurally unique kappa opioid receptor agonist.
Topics: Acetic Acid; Analgesics; Animals; Diterpenes; Diterpenes, Clerodane; Dose-Response Relationship, Drug; Hot Temperature; Male; Mice; Muscle Contraction; Naltrexone; Nociceptors; Pain Measurement; Plant Leaves; Psychotropic Drugs; Reaction Time; Receptors, Opioid, kappa | 2006 |
Inhibition of morphine tolerance by processed Aconiti tuber is mediated by kappa-opioid receptors.
Topics: Aconitum; Analgesics, Opioid; Animals; Cinnamates; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Drugs, Chinese Herbal; Male; Mice; Morphine; Morphine Derivatives; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Pain Threshold; Plant Tubers; Receptors, Opioid, kappa; Time Factors | 2006 |
Quantitative no-net-flux microdialysis permits detection of increases and decreases in dopamine uptake in mouse nucleus accumbens.
Topics: Animals; Chromatography, High Pressure Liquid; Dopamine; Electrochemistry; Male; Mice; Mice, Inbred C57BL; Microdialysis; Models, Statistical; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Predictive Value of Tests; Receptors, Opioid, kappa | 2006 |
Involvements of mu- and kappa-opioid receptors in morphine-induced antinociception in the nucleus accumbens of rats.
Topics: Analgesics, Opioid; Animals; Male; Morphine; Naloxone; Naltrexone; Nucleus Accumbens; Pain; Physical Stimulation; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2006 |
Endogenous activation of supraoptic nucleus kappa-opioid receptors terminates spontaneous phasic bursts in rat magnocellular neurosecretory cells.
Topics: Action Potentials; Animals; Electric Stimulation; In Vitro Techniques; Male; Naltrexone; Narcotic Antagonists; Neurons; Rats; Rats, Long-Evans; Receptors, Opioid, kappa; Statistics, Nonparametric; Supraoptic Nucleus; Time Factors; Vasopressins | 2006 |
Characterization of the antinociceptive effects of oxycodone in diabetic mice.
Topics: Analgesics, Opioid; Animals; Area Under Curve; Diabetes Mellitus, Experimental; Injections, Intraventricular; Injections, Spinal; Injections, Subcutaneous; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Oxycodone; Pain; Pain Measurement; Streptozocin | 2006 |
Vagotonic effects of enkephalin are not mediated by sympatholytic mechanisms.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Dogs; Enkephalin, Methionine; Female; Heart Rate; Male; Naltrexone; Receptors, Opioid, kappa; Sympatholytics; Vagus Nerve | 2006 |
Endogenous kappa opioid receptor systems modulate the responsiveness of mesoaccumbal dopamine neurons to ethanol.
Topics: Animals; Dopamine; Ethanol; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microdialysis; Naltrexone; Neurons; Nucleus Accumbens; Receptors, Opioid, kappa | 2006 |
Downstream regulatory element antagonistic modulator regulates islet prodynorphin expression.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Calcium; Cell Line; Cell Nucleus; DNA; Dynorphins; Electrophoretic Mobility Shift Assay; Enkephalins; Gene Expression Regulation; Glucagon; Glucagon-Secreting Cells; Glucose; Humans; Insulin-Secreting Cells; Islets of Langerhans; Kv Channel-Interacting Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Naltrexone; Protein Binding; Protein Precursors; Receptors, Opioid, kappa; Repressor Proteins | 2006 |
Involvement of mu- and delta-opioid receptors in the antinociceptive effects induced by AMPA receptor antagonist in the spinal cord of rats.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Interactions; Male; Naltrexone; Pain Measurement; Physical Stimulation; Quinoxalines; Rats; Rats, Wistar; Reaction Time; Receptors, AMPA; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord; Wakefulness | 2006 |
Reduction of lipopolysaccharide-induced interleukin-6 production by the kappa opioid U50,488 in a mouse monocyte-like cell line.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cell Line, Tumor; Cell Survival; Dactinomycin; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Gene Expression; Interleukin-6; Lipopolysaccharides; Mice; Monocytes; Naltrexone; Narcotic Antagonists; Oligopeptides; Receptors, Opioid, kappa; RNA Stability; Time Factors; Transcription, Genetic; Tumor Necrosis Factor-alpha | 2006 |
Kappa opioid receptor activation of p38 MAPK is GRK3- and arrestin-dependent in neurons and astrocytes.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Arrestins; Astrocytes; beta-Adrenergic Receptor Kinases; Cells, Cultured; Corpus Striatum; G-Protein-Coupled Receptor Kinase 3; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Naltrexone; Narcotic Antagonists; Neurons; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Rats; Receptors, Opioid, kappa; Signal Transduction | 2006 |
Reinforcing properties of ethanol in neonatal rats: involvement of the opioid system.
Topics: Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Body Weight; Bottle Feeding; Central Nervous System Depressants; Cesarean Section; Conditioning, Classical; Ethanol; Female; Male; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Sex Factors; Somatostatin | 2006 |
Schild (apparent pA2) analysis of a kappa-opioid antagonist in Planaria.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Algorithms; Analgesics, Non-Narcotic; Animals; Dose-Response Relationship, Drug; Locomotion; Naltrexone; Narcotic Antagonists; Planarians; Receptors, Opioid, kappa; Regression Analysis | 2006 |
Kappa-opioid receptor modulation of accumbal dopamine concentration during operant ethanol self-administration.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Area Under Curve; Behavior, Animal; Central Nervous System Depressants; Conditioning, Operant; Dopamine; Dose-Response Relationship, Drug; Drinking Behavior; Drug Interactions; Ethanol; Male; Microdialysis; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Rats; Rats, Long-Evans; Receptors, Opioid, kappa; Self Administration | 2006 |
Atypical anxiolytic-like response to naloxone in benzodiazepine-resistant 129S2/SvHsd mice: role of opioid receptor subtypes.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Drug Resistance; Male; Maze Learning; Mice; Mice, Inbred C57BL; Naloxone; Naltrexone; Opioid Peptides; Receptors, Opioid; Species Specificity | 2006 |
Anticonvulsive effects of kappa-opioid receptor modulation in an animal model of ethanol withdrawal.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Alcohol-Induced Disorders, Nervous System; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Anticonvulsants; Brain; Central Nervous System Depressants; Disease Models, Animal; Drug Interactions; Drug Synergism; Ethanol; Male; Naltrexone; Receptors, Opioid, kappa; Seizures; Species Specificity; Substance Withdrawal Syndrome; Treatment Outcome | 2006 |
Beta-endorphin differentially affects inflammation in two inbred rat strains.
Topics: Animals; beta-Endorphin; Concanavalin A; Dose-Response Relationship, Drug; Edema; Female; Granulocytes; Hindlimb; Inflammation; Male; Naltrexone; Narcotic Antagonists; Neurotransmitter Agents; Nitric Oxide; Phagocytosis; Rats; Rats, Inbred Strains; Receptors, Opioid, delta; Receptors, Opioid, kappa; Species Specificity | 2006 |
Expression and localization of delta-, kappa-, and mu-opioid receptors in human spermatozoa and implications for sperm motility.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adult; Analgesics, Opioid; Humans; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sperm Motility; Spermatozoa; Tissue Distribution | 2006 |
Kappa-opioid receptor antagonism improves recovery from myocardial stunning in chronically instrumented dogs.
Topics: Animals; beta-Endorphin; Blood Pressure; Coronary Circulation; Dogs; Dynorphins; Epinephrine; Female; Heart Rate; Male; Myocardial Stunning; Naltrexone; Narcotic Antagonists; Norepinephrine; Radioimmunoassay; Receptors, Opioid, kappa; Ventricular Function, Left | 2006 |
Involvement of opioid receptors in oxytocin-induced antinociception in the nucleus accumbens of rats.
Topics: Analgesics; Animals; Hot Temperature; Male; Microinjections; Naloxone; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Oxytocin; Pain Measurement; Physical Stimulation; Rats; Rats, Wistar; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2007 |
Paradoxical hyperalgesia induced by mu-opioid receptor agonist endomorphin-2, but not endomorphin-1, microinjected into the centromedial amygdala of the rat.
Topics: Amygdala; Analgesics, Opioid; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Dynorphins; Excitatory Amino Acid Antagonists; Hyperalgesia; Immune Sera; Male; Microinjections; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain Measurement; Rabbits; Rats; Receptors, Opioid, mu; Time Factors | 2007 |
Pharmacological and genetic manipulation of kappa opioid receptors: effects on cocaine- and pentylenetetrazol-induced convulsions and seizure kindling.
Topics: Analgesics; Animals; Behavior, Animal; Benzeneacetamides; Cocaine; Dose-Response Relationship, Drug; Drug Interactions; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Naltrexone; Narcotic Antagonists; Pentylenetetrazole; Pyrrolidines; Receptors, Opioid, kappa; Seizures | 2007 |
Hallucinatory and rewarding effect of salvinorin A in zebrafish: kappa-opioid and CB1-cannabinoid receptor involvement.
Topics: Animals; Behavior, Addictive; Behavior, Animal; Conditioning, Psychological; Diterpenes; Diterpenes, Clerodane; Dose-Response Relationship, Drug; Hallucinogens; Models, Animal; Motor Activity; Naltrexone; Narcotic Antagonists; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Opioid, kappa; Reinforcement, Psychology; Reproducibility of Results; Reward; Rimonabant; Swimming; Time Factors; Zebrafish | 2007 |
Different effects of opioid antagonists on mu-, delta-, and kappa-opioid receptors with and without agonist pretreatment.
Topics: Benzylidene Compounds; Cells, Cultured; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Morphine; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Signal Transduction | 2007 |
Inhibition of tolerance to spinal morphine antinociception by low doses of opioid receptor antagonists.
Topics: Animals; Dose-Response Relationship, Drug; Drug Tolerance; Hyperalgesia; Injections, Spinal; Male; Morphine; Naltrexone; Narcotic Antagonists; Peptide Fragments; Peptides; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Somatostatin; Theophylline | 2007 |
Sciatic nerve ligation-induced proliferation of spinal cord astrocytes is mediated by kappa opioid activation of p38 mitogen-activated protein kinase.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Astrocytes; Cell Proliferation; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Glial Fibrillary Acidic Protein; Hyperalgesia; Hyperesthesia; Imidazoles; In Vitro Techniques; Ligation; Lumbar Vertebrae; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Naltrexone; Narcotic Antagonists; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Receptors, Opioid, kappa; Sciatic Nerve; Spinal Cord | 2007 |
Transient activation of the CA3 Kappa opioid system in the dorsal hippocampus modulates complex memory processing in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analysis of Variance; Animals; Avoidance Learning; Conditioning, Classical; Dose-Response Relationship, Drug; Fear; Hippocampus; Male; Maze Learning; Memory; Mice; Mice, Inbred C57BL; Microinjections; Naltrexone; Receptors, Opioid, kappa; Spatial Behavior | 2007 |
Involvement of delta-and mu-opioid receptors in the delayed cerebral ischemic tolerance induced by repeated electroacupuncture preconditioning in rats.
Topics: Animals; Brain Ischemia; Electroacupuncture; Enkephalin, Methionine; Immunohistochemistry; Ischemic Preconditioning; Male; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Somatostatin | 2007 |
Selectivity of delta- and kappa-opioid ligands depends on the route of central administration in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzylidene Compounds; Enkephalin, D-Penicillamine (2,5)-; Injections, Intraventricular; Injections, Spinal; Ligands; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Receptors, Opioid, kappa | 2007 |
The effect of kappa opioid receptor antagonism on energy expenditure in the obese Zucker rat.
Topics: Analysis of Variance; Animals; Body Temperature; Body Weight; Calorimetry, Indirect; Cardiac Catheterization; Disease Models, Animal; Drug Evaluation, Preclinical; Energy Intake; Energy Metabolism; Injections, Intravenous; Male; Motor Activity; Naltrexone; Narcotic Antagonists; Obesity; Rats; Rats, Zucker; Receptors, Opioid, kappa; Respiration; Telemetry | 2007 |
Oxycodone's mechanism of action and potency differences after spinal and systemic routes of administration.
Topics: Analgesics, Opioid; Animals; Injections, Intravenous; Injections, Spinal; Naltrexone; Oxycodone; Rats | 2007 |
Pharmacological evidence for a motivational role of kappa-opioid systems in ethanol dependence.
Topics: Administration, Inhalation; Alcoholism; Animals; Central Nervous System Depressants; Conditioning, Operant; Data Interpretation, Statistical; Dynorphins; Ethanol; Injections, Intraventricular; Male; Motivation; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Self Administration; Substance Withdrawal Syndrome | 2008 |
Sexually dimorphic recruitment of spinal opioid analgesic pathways by the spinal application of morphine.
Topics: Animals; Animals, Newborn; Antibodies; Dose-Response Relationship, Drug; Dynorphins; Female; Injections, Spinal; Male; Morphine; Naltrexone; Narcotic Antagonists; Neural Pathways; Orchiectomy; Ovariectomy; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sex Factors; Spinal Cord; Sufentanil; Virilism | 2007 |
Nociceptin/orphanin FQ decreases serotonin efflux in the rat brain but in contrast to a kappa-opioid has no antagonistic effect on mu-opioid-induced increases in serotonin efflux.
Topics: Animals; Dose-Response Relationship, Drug; Male; Microdialysis; Naltrexone; Narcotic Antagonists; Nociceptin; Nucleus Accumbens; Opioid Peptides; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Serotonin | 2007 |
[Role of kappa-opioid receptors in the regulation of cardiac resistance to arrhythmogenic effects of ischemia and reperfusion].
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Myocardial Reperfusion Injury; Myocardium; Naloxone; Naltrexone; Piperazines; Pyrrolidines; Quaternary Ammonium Compounds; Rats; Rats, Wistar; Receptors, Opioid, kappa | 2006 |
Effects of selective opioid receptor antagonists on alcohol-induced and nicotine-induced antinociception.
Topics: Analgesics; Animals; Central Nervous System Depressants; Ethanol; Hot Temperature; Male; Naltrexone; Narcotic Antagonists; Nicotine; Nicotinic Agonists; Pain Measurement; Peptide Fragments; Peptides; Rats; Rats, Wistar; Reaction Time; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin | 2007 |
Central inhibition of opioid receptor subtypes and its effect on haemorrhagic hypotension in conscious sheep.
Topics: Animals; Bradycardia; Enkephalin, Leucine; Hemorrhage; Hypotension; Injections, Intraventricular; Models, Animal; Naltrexone; Narcotic Antagonists; Random Allocation; Receptors, Opioid, delta; Receptors, Opioid, kappa; Regional Blood Flow; Renal Circulation; Sheep | 2007 |
Ethanol alters the effect of kappa receptor ligands on dopamine release in the nucleus accumbens.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Central Nervous System Stimulants; Dopamine; Drug Administration Schedule; Drug Interactions; Drug Tolerance; Dynorphins; Ethanol; Male; Naltrexone; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa | 2007 |
Naloxone rapidly evokes endogenous kappa opioid receptor-mediated hyperalgesia in naïve mice pretreated briefly with GM1 ganglioside or in chronic morphine-dependent mice.
Topics: Analgesics, Opioid; Animals; Chronic Disease; Dipeptides; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Synergism; G(M1) Ganglioside; Hyperalgesia; Male; Mice; Morphine; Morphine Dependence; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Opioid Peptides; Receptors, Opioid, kappa; Substance Withdrawal Syndrome | 2007 |
Kappa agonist-induced reinstatement of cocaine seeking in squirrel monkeys: a role for opioid and stress-related mechanisms.
Topics: Animals; Behavior, Addictive; Benzofurans; Clonidine; Cocaine-Related Disorders; Corticotropin-Releasing Hormone; Male; Naltrexone; Norepinephrine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Saimiri; Self Administration; Stress, Psychological | 2007 |
Involvement of kappa opioid receptors in formalin-induced inhibition of analgesic tolerance to morphine in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Chronic Disease; Drug Tolerance; Formaldehyde; Male; Mice; Morphine; Naltrexone; Oligonucleotides, Antisense; Pain; Pain Measurement; Pain Threshold; Receptors, Opioid, delta; Receptors, Opioid, kappa; Tail | 2007 |
Intramuscular administration of morphine reduces mustard-oil-induced craniofacial-muscle pain behavior in lightly anesthetized rats.
Topics: Analgesics; Anesthesia, General; Animals; Inflammation; Injections; Injections, Intramuscular; Male; Masseter Muscle; Morphine; Mustard Plant; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Pain; Plant Oils; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Single-Blind Method; Somatostatin | 2008 |
Pharmacological selectivity of CTAP in a warm water tail-withdrawal antinociception assay in rats.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Injections, Intraventricular; Injections, Subcutaneous; Male; Naltrexone; Narcotic Antagonists; Pain Threshold; Peptide Fragments; Peptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin; Tail; Thermosensing | 2008 |
Catalytic aerobic oxidation of nor-binaltorphimine (nor-BNI) analogs without 4,5-epoxy bridge affords a more selective ligand for kappa opioid receptor than the representative kappa antagonist nor-BNI.
Topics: Aerobiosis; Catalysis; Epoxy Compounds; Ligands; Methylation; Models, Chemical; Naltrexone; Narcotic Antagonists; Oxidation-Reduction; Oxygen; Platinum; Receptors, Opioid, kappa | 2007 |
Involvement of kappa-opioid and endocannabinoid system on Salvinorin A-induced reward.
Topics: Analysis of Variance; Animals; Antioxidants; Behavior, Animal; Cannabinoid Receptor Modulators; Conditioning, Operant; Diterpenes; Diterpenes, Clerodane; Dopamine; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Interactions; Endocannabinoids; Male; Microdialysis; Motor Activity; Naltrexone; Narcotic Antagonists; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Opioid, kappa; Reward; Rimonabant; Self Administration | 2008 |
Expression of a Gi-coupled receptor in the heart causes impaired Ca2+ handling, myofilament injury, and dilated cardiomyopathy.
Topics: Actin Cytoskeleton; Animals; Calcium; Cardiomyopathy, Dilated; Cyclic AMP; GTP-Binding Protein alpha Subunits, Gi-Go; Matrix Metalloproteinase 2; Mice; Mice, Transgenic; Myocardial Contraction; Myocardium; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, G-Protein-Coupled; Receptors, Opioid, kappa; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Signal Transduction; Time Factors; Ventricular Function, Left | 2008 |
Activation of kappa-opioid receptor as a method for prevention of ischemic and reperfusion arrhythmias: role of protein kinase C and K(ATP) channels.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Alkaloids; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzophenanthridines; Glyburide; Male; Myocardial Reperfusion Injury; Naltrexone; Oxymorphone; Potassium Channels; Protein Kinase C; Rats; Rats, Wistar; Receptors, Opioid, kappa | 2007 |
Opioid receptors are involved in the sedative and antinociceptive effects of hesperidin as well as in its potentiation with benzodiazepines.
Topics: Acetic Acid; Alprazolam; Analgesics; Animals; Behavior, Animal; Benzodiazepines; Dose-Response Relationship, Drug; Drug Synergism; Flunitrazepam; Hesperidin; Hypnotics and Sedatives; Injections, Intraperitoneal; Male; Mice; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Receptors, Opioid | 2008 |
Morphine postconditioning protects against reperfusion injury in the isolated rat hearts.
Topics: Analgesics, Opioid; Animals; Anti-Arrhythmia Agents; Cardiotonic Agents; Decanoic Acids; Dose-Response Relationship, Drug; Hydroxy Acids; In Vitro Techniques; Ischemic Preconditioning, Myocardial; Male; Morphine; Myocardial Infarction; Naloxone; Naltrexone; Narcotic Antagonists; Potassium Channels; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2008 |
The kappa-opioid receptor antagonist nor-BNI inhibits cocaine and amphetamine, but not cannabinoid (WIN 52212-2), abstinence-induced withdrawal in planarians: an instance of 'pharmacologic congruence'.
Topics: Amphetamine; Analgesics; Analysis of Variance; Animals; Behavior, Animal; Benzoxazines; Cocaine; Disease Models, Animal; Dopamine Uptake Inhibitors; Drug Interactions; Morpholines; Naltrexone; Naphthalenes; Narcotic Antagonists; Planarians; Substance Withdrawal Syndrome; Time Factors | 2008 |
YFa, a chimeric opioid peptide, induces kappa-specific antinociception with no tolerance development during 6 days of chronic treatment.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, Methionine; FMRFamide; Gene Expression Regulation; Male; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain Measurement; Rats; Rats, Wistar; Reaction Time; Receptors, Opioid, kappa; Receptors, Opioid, mu; Time Factors | 2008 |
The dysphoric component of stress is encoded by activation of the dynorphin kappa-opioid system.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Conditioning, Operant; Corticotropin-Releasing Hormone; Dose-Response Relationship, Drug; Drug Interactions; Dynorphins; Enkephalins; Mice; Mice, Inbred C57BL; Mice, Knockout; Naltrexone; Narcotic Antagonists; Odorants; Phosphorylation; Protein Precursors; Receptors, Opioid, kappa; Stress, Physiological; Swimming; Urocortins | 2008 |
Evidence that cardioprotection by postconditioning involves preservation of myocardial opioid content and selective opioid receptor activation.
Topics: Analgesics, Opioid; Animals; Endorphins; Enkephalins; Ischemic Preconditioning, Myocardial; Male; Myocardial Infarction; Myocardium; Naltrexone; Norepinephrine; Peptide Fragments; Peptides; Protein Precursors; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Somatostatin | 2008 |
Methionine-enkephalin modulation of hydrogen peroxide (H2O2) release by rat peritoneal macrophages involves different types of opioid receptors.
Topics: Animals; Benzylidene Compounds; Carcinogens; Dose-Response Relationship, Drug; Enkephalin, Methionine; Hydrogen Peroxide; Macrophages, Peritoneal; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tetradecanoylphorbol Acetate | 2008 |
The comparison of effects of processed Aconiti tuber, U50488H and MK-801 on the antinociceptive tolerance to morphine.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Aconitum; Analgesics, Opioid; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Tolerance; Male; Mice; Morphine; Naltrexone; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa | 2008 |
The analgesic effect of paeoniflorin on neonatal maternal separation-induced visceral hyperalgesia in rats.
Topics: Adrenergic alpha-Antagonists; alpha-Methyltyrosine; Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Benzoates; Bridged-Ring Compounds; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Interactions; Enzyme Inhibitors; Female; Glucosides; Hyperalgesia; Male; Maternal Deprivation; Monoterpenes; Naltrexone; Narcotic Antagonists; Pain Measurement; Pain Threshold; Pregnancy; Rats; Rats, Sprague-Dawley; Yohimbine | 2008 |
Activation of kappa opioid receptors decreases synaptic transmission and inhibits long-term potentiation in the basolateral amygdala of the mouse.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amygdala; Analgesics, Non-Narcotic; Animals; Chronic Disease; Electric Stimulation; Electrophysiology; Emotions; Extinction, Psychological; Long-Term Potentiation; Male; Mice; Mice, Inbred C57BL; Naltrexone; Pain; Receptors, Opioid, kappa; Synaptic Transmission | 2009 |
The spinal antinociceptive effects of endomorphins in rats: behavioral and G protein functional studies.
Topics: Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Partial Agonism; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Guanosine 5'-O-(3-Thiotriphosphate); Injections, Spinal; Male; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Spinal Cord; Sulfur Radioisotopes; Thalamus; Time Factors | 2008 |
In vivo characterization of (-)(-)MCL-144 and (+)(-)MCL-193: isomeric, bivalent ligands with mu/kappa agonist properties.
Topics: Alkanes; Analgesics; Animals; Brain; CHO Cells; Cricetinae; Cricetulus; Fumarates; Guanosine 5'-O-(3-Thiotriphosphate); Half-Life; Male; Morphinans; Morphine; Naltrexone; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stereoisomerism | 2008 |
Possible involvement of dynorphin A release via mu1-opioid receptor on supraspinal antinociception of endomorphin-2.
Topics: Analgesics; Animals; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Immune Sera; Injections, Intraventricular; Male; Mice; Naloxone; Naltrexone; Oligopeptides; Protein Precursors; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2008 |
Genetic and early environmental contributions to alcohol's aversive and physiological effects.
Topics: Animals; Avoidance Learning; Central Nervous System Depressants; Conditioning, Operant; Data Interpretation, Statistical; Dynorphins; Ethanol; Extinction, Psychological; Female; Hypothermia; Maternal Behavior; Motivation; Naltrexone; Rats; Receptors, Opioid, kappa; Taste | 2008 |
Crucial role of peripheral kappa-opioid receptors in a model of periodontal disease in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Chronic Periodontitis; Disease Models, Animal; Male; Morphine; Naltrexone; Narcotic Antagonists; Peripheral Nervous System; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa | 2008 |
kappa-Opioid receptor stimulation inhibits augmentation of Ca(2+) transient and hypertrophy induced by isoprenaline in neonatal rat ventricular myocytes - Role of CaMKIIdelta(B).
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Animals, Newborn; Benzylamines; Calcium Channel Blockers; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Nucleus; Cell Size; Cells, Cultured; Hypertrophy; Isoproterenol; Myocytes, Cardiac; Naltrexone; Narcotic Antagonists; Propranolol; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta-1; Receptors, Opioid, kappa; Sulfonamides; Verapamil | 2008 |
C2 spinal cord stimulation induces dynorphin release from rat T4 spinal cord: potential modulation of myocardial ischemia-sensitive neurons.
Topics: Animals; Brain Stem; Coronary Vessels; Dynorphins; Electric Stimulation; Excitatory Amino Acid Agonists; Ibotenic Acid; Image Processing, Computer-Assisted; Immunohistochemistry; Male; Myocardial Ischemia; Naltrexone; Narcotic Antagonists; Neural Pathways; Neurons; Posterior Horn Cells; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P | 2008 |
Repeated swim stress induces kappa opioid-mediated activation of extracellular signal-regulated kinase 1/2.
Topics: Analgesics, Opioid; Animals; Caudate Nucleus; Dynorphins; G-Protein-Coupled Receptor Kinase 3; Immunoblotting; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Naltrexone; Narcotic Antagonists; Neurotransmitter Agents; Nucleus Accumbens; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Receptors, Opioid, kappa; Signal Transduction; Stress, Psychological; Swimming | 2008 |
Prodynorphin-derived peptides are critical modulators of anxiety and regulate neurochemistry and corticosterone.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amygdala; Animals; Anxiety; Brain Stem; Corticosterone; Corticotropin-Releasing Hormone; Dynorphins; Enkephalins; Exploratory Behavior; Female; Guanidines; Hypothalamus; Male; Maze Learning; Mesencephalon; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphinans; Naltrexone; Neuropeptide Y; Neuropeptides; Protein Precursors; Raphe Nuclei; Receptors, Opioid, kappa; Stress, Psychological | 2009 |
Kappa-opioid system regulates the long-lasting behavioral adaptations induced by early-life exposure to methylphenidate.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Anxiety; Behavior, Animal; Central Nervous System Stimulants; Cocaine; Conditioning, Psychological; Food Preferences; Male; Methylphenidate; Motor Activity; Naltrexone; Psychotropic Drugs; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Stress, Psychological | 2009 |
Dynorphin inhibits NEP activity in R1.1 mouse thymoma cells.
Topics: Animals; Cell Line, Tumor; Dynorphins; Mice; Naltrexone; Narcotic Antagonists; Neprilysin; Receptors, Opioid, kappa; Thiophenes; Thymoma; Thymus Neoplasms | 2008 |
Role of opioid system in modulation of pain sensitivity under conditons of low and high environmental temperature.
Topics: Analgesics, Opioid; Animals; Cold Temperature; Hot Temperature; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Pain Threshold; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2008 |
Protection conferred by Corticotropin-releasing hormone in rat primary cortical neurons against chemical ischemia involves opioid receptor activation.
Topics: Animals; Brain Ischemia; Cell Death; Cells, Cultured; Corticotropin-Releasing Hormone; Dynorphins; Enkephalins; Indoles; Naltrexone; Narcotic Antagonists; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Potassium Cyanide; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone; Receptors, Opioid, delta; Receptors, Opioid, kappa; RNA, Messenger | 2009 |
Inhibitory effect of low-dose pentazocine on the development of antinociceptive tolerance to morphine.
Topics: Analgesics, Opioid; Animals; Cinnamates; Dose-Response Relationship, Drug; Drug Tolerance; Male; Mice; Mice, Inbred ICR; Morphine; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Pain Measurement; Pentazocine; Pressure; Receptors, Opioid, kappa | 2009 |
Endogenous kappa opioid activation mediates stress-induced deficits in learning and memory.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Behavior, Animal; Enkephalins; Gene Expression Regulation; Immobility Response, Tonic; Learning Disabilities; Male; Memory Disorders; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Naltrexone; Narcotic Antagonists; Protein Precursors; Receptors, Opioid, kappa; Recognition, Psychology; Stress, Psychological; Swimming; Time Factors | 2009 |
Effects of TRK-820, a selective kappa opioid receptor agonist, on rat schizophrenia models.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Dopamine; Extracellular Space; Hyperkinesis; Male; Morphinans; Naltrexone; Phencyclidine; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Schizophrenia; Serotonin; Spiro Compounds | 2009 |
Potential anxiolytic- and antidepressant-like effects of salvinorin A, the main active ingredient of Salvia divinorum, in rodents.
Topics: Amidohydrolases; Animals; Anti-Anxiety Agents; Antidepressive Agents; Behavior, Animal; Binding, Competitive; Brain; Cyclohexanols; Diterpenes, Clerodane; Dose-Response Relationship, Drug; Emotions; Injections, Subcutaneous; Male; Mice; Models, Animal; Motor Activity; Naltrexone; Narcotic Antagonists; Piperidines; Pyrazoles; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Opioid, kappa; Salvia; Swimming | 2009 |
Opioid, cannabinoid CB1 and NOP receptors do not mediate APAP-induced hypothermia in rats.
Topics: Acetaminophen; Aminoquinolines; Animals; Benzamides; Body Temperature; Hypothermia, Induced; Male; Naltrexone; Nociceptin Receptor; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Opioid; Rimonabant | 2009 |
Inhibition of kappa opioid receptors attenuated increased cocaine intake in rats with extended access to cocaine.
Topics: Animals; CHO Cells; Cocaine; Conditioning, Operant; Cricetinae; Cricetulus; Drug Interactions; Male; Naltrexone; Rats; Rats, Wistar; Receptors, Opioid, kappa; Reinforcement Schedule; Self Administration | 2009 |
Selective mu- and kappa-opioid receptor antagonists administered into the nucleus accumbens interfere with rapid tolerance to ethanol in rats.
Topics: Animals; Drug Tolerance; Ethanol; Male; Microinjections; Naloxone; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Rats; Rats, Wistar; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2009 |
The unconditioned fear produced by morphine withdrawal is regulated by mu- and kappa-opioid receptors in the midbrain tectum.
Topics: Analgesics, Opioid; Animals; Catheterization; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Escape Reaction; Fear; Freezing Reaction, Cataleptic; Male; Microinjections; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid, kappa; Receptors, Opioid, mu; Substance Withdrawal Syndrome; Tectum Mesencephali | 2009 |
Central adiponectin functions to inhibit arginine vasopressin release in conscious rats.
Topics: Adiponectin; Animals; Arginine Vasopressin; Blood Pressure; Consciousness; Dose-Response Relationship, Drug; Down-Regulation; Heart Rate; Hypovolemia; Injections, Intraventricular; Male; Naltrexone; Narcotic Antagonists; Osmolar Concentration; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Time Factors; Water-Electrolyte Balance | 2009 |
Central administration of somatostatin stimulates feeding behavior in chicks.
Topics: Alkylating Agents; Animals; Animals, Newborn; Chickens; Eating; Enkephalin, Leucine; Hormones; Male; Naltrexone; Narcotic Antagonists; Neuropeptides; Receptors, Opioid; Somatostatin | 2009 |
Prodynorphin gene deficiency potentiates nalbuphine-induced behavioral sensitization and withdrawal syndrome in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Area Under Curve; Blotting, Western; Dopamine; Enkephalins; Gene Expression; Genes, fos; Mice; Mice, Knockout; Microdialysis; Motor Activity; Nalbuphine; Naloxone; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Protein Precursors; Receptors, Opioid, kappa; Reverse Transcriptase Polymerase Chain Reaction; Substance Withdrawal Syndrome | 2009 |
The antinociceptive properties of reboxetine in acute pain.
Topics: Adrenergic Antagonists; Analgesics; Animals; Antidepressive Agents; Clonidine; Disease Models, Animal; Drug Interactions; Male; Mice; Mice, Inbred ICR; Morphine; Morpholines; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Reboxetine; Receptors, Opioid, mu | 2009 |
Myocardial apoptosis and infarction after ischemia/reperfusion are attenuated by kappa-opioid receptor agonist.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Antihypertensive Agents; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Caspase 9; DNA Fragmentation; Male; Microscopy, Electron, Transmission; Myocardial Infarction; Myocardium; Naltrexone; Narcotic Antagonists; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reperfusion Injury | 2009 |
Association of increased pain threshold by noise with central opioid neurons.
Topics: Analgesia; Animals; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Noise; Opioid Peptides; Pain Measurement; Pain Threshold; Receptors, Opioid, delta; Receptors, Opioid, mu; Stress, Physiological | 2009 |
Characteristics and comparative severity of respiratory response to toxic doses of fentanyl, methadone, morphine, and buprenorphine in rats.
Topics: Animals; Blood Gas Analysis; Buprenorphine; Catheterization; Fentanyl; Lactic Acid; Male; Methadone; Morphine; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Narcotics; Plethysmography, Whole Body; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Respiratory Insufficiency; Respiratory Mechanics | 2009 |
Dehydration-induced modulation of kappa-opioid inhibition of vasopressin neurone activity.
Topics: Action Potentials; Animals; Cholecystokinin; Dehydration; Electrophysiology; Enkephalins; Female; Hypernatremia; Hyponatremia; Immunohistochemistry; In Situ Hybridization; Naltrexone; Narcotic Antagonists; Neurons; Oxytocin; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; RNA, Messenger; Vasopressins | 2009 |
Attenuation of cocaine-induced reinstatement of drug seeking in squirrel monkeys: kappa opioid and serotonergic mechanisms.
Topics: Animals; Benzofurans; Citalopram; Cocaine-Related Disorders; Dose-Response Relationship, Drug; Fluoxetine; Ligands; Naltrexone; Pyrrolidines; Receptors, Opioid, kappa; Saimiri; Selective Serotonin Reuptake Inhibitors; Self Administration; Serotonin; Serotonin 5-HT1 Receptor Agonists | 2010 |
Activation of the kappa opioid receptor in the dorsal raphe nucleus mediates the aversive effects of stress and reinstates drug seeking.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analysis of Variance; Animals; Cocaine; Enzyme-Linked Immunosorbent Assay; Immunohistochemistry; Lentivirus; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Naltrexone; Raphe Nuclei; Receptors, Opioid, kappa; Stress, Physiological; Ventral Tegmental Area | 2009 |
Remifentanil post-conditioning attenuates cardiac ischemia-reperfusion injury via kappa or delta opioid receptor activation.
Topics: Analgesics, Opioid; Animals; Blood Pressure; Cardiotonic Agents; Dose-Response Relationship, Drug; Heart Rate; In Vitro Techniques; Ischemic Preconditioning, Myocardial; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Naltrexone; Narcotic Antagonists; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Remifentanil; Somatostatin | 2010 |
Mu and kappa opioids modulate mouse embryonic stem cell-derived neural progenitor differentiation via MAP kinases.
Topics: Analgesics, Opioid; Animals; Antigens; Benzeneacetamides; Cell Differentiation; Cells, Cultured; Drug Interactions; Embryo, Mammalian; Embryonic Stem Cells; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enzyme Inhibitors; Glial Fibrillary Acidic Protein; Mice; Mitogen-Activated Protein Kinase Kinases; Naltrexone; Narcotic Antagonists; Oligodendroglia; Peptides; Proteoglycans; Pyrrolidines; Receptors, Opioid, kappa; Receptors, Opioid, mu; Time Factors; Tretinoin; Tubulin | 2010 |
Combining functional magnetic resonance imaging with mouse genomics: new options in pain research.
Topics: Animals; Biomedical Research; Brain Mapping; Disease Models, Animal; Genomics; Hot Temperature; Image Processing, Computer-Assisted; Kv Channel-Interacting Proteins; Magnetic Resonance Imaging; Male; Mice; Mice, Knockout; Naltrexone; Narcotic Antagonists; Oxygen; Pain; Physical Stimulation; Repressor Proteins | 2010 |
A prolonged protein kinase C-mediated, opioid-related antinociceptive effect of st John's Wort in mice.
Topics: Acetic Acid; Analgesics; Analgesics, Opioid; Animals; Anthracenes; Chromatography, High Pressure Liquid; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Administration Schedule; Drug Compounding; Hypericum; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Pain Threshold; Perylene; Phorbol Esters; Phytotherapy; Protein Kinase C; Quercetin; Somatostatin; Spectrometry, Mass, Electrospray Ionization; Statistics, Nonparametric; Time Factors | 2010 |
Forebrain PENK and PDYN gene expression levels in three inbred strains of mice and their relationship to genotype-dependent morphine reward sensitivity.
Topics: Animals; Behavior, Addictive; Behavior, Animal; Conditioning, Psychological; Cues; Enkephalins; Gene Expression Regulation; Genotype; In Situ Hybridization; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Morphine Dependence; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Phenotype; Protein Precursors; Receptors, Opioid, kappa; Reward; RNA, Messenger; Species Specificity | 2010 |
Mu and kappa opioid receptor expression in the mediobasal hypothalamus and effectiveness of selective antagonists on prolactin release during lactation.
Topics: Analysis of Variance; Animals; Animals, Suckling; Chromatography, High Pressure Liquid; Dopamine; Female; Hypothalamus; Injections, Intraventricular; Lactation; Naltrexone; Neurons; Prolactin; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sucking Behavior | 2010 |
Antinociceptive effects of galanin in the central nucleus of amygdala of rats, an involvement of opioid receptors.
Topics: Amygdala; Animals; Galanin; Hindlimb; Hot Temperature; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Physical Stimulation; Rats; Rats, Wistar; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Time Factors | 2010 |
Effects of kappa opioids in an assay of pain-depressed intracranial self-stimulation in rats.
Topics: Analgesics; Analgesics, Opioid; Animals; Benzeneacetamides; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Lactic Acid; Male; Medial Forebrain Bundle; Morphine; Naltrexone; Pain; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reinforcement, Psychology; Self Stimulation | 2010 |
Involvement of the kappa-opioid receptor in nitrous oxide-induced analgesia in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics, Non-Narcotic; Animals; Benzamides; Male; Mice; Mice, Inbred C57BL; Naltrexone; Narcotic Antagonists; Nitrous Oxide; Pain; Piperazines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Treatment Outcome | 2010 |
The effects of kappa-opioid receptor ligands on prepulse inhibition and CRF-induced prepulse inhibition deficits in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzeneacetamides; Corticotropin-Releasing Hormone; Diterpenes, Clerodane; Dose-Response Relationship, Drug; Ligands; Male; Naltrexone; Neural Inhibition; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reflex, Startle | 2010 |
Consequences of opioid receptor mutation on actions of univalent and bivalent kappa and delta ligands.
Topics: Amides; Animals; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Guanidines; Ligands; Male; Mice; Mice, Knockout; Naltrexone; Oligopeptides; Pain; Protein Multimerization; Receptors, Opioid, delta; Receptors, Opioid, kappa | 2010 |
Evidence of central and peripheral sensitization in a rat model of narcotic bowel-like syndrome.
Topics: Abdominal Pain; Animals; CD11b Antigen; Chymases; Colon; Delayed-Action Preparations; Disease Models, Animal; Gastrointestinal Transit; Hyperalgesia; Immunohistochemistry; Intestinal Mucosa; Male; Mast Cells; Microglia; Minocycline; Morphine; Naltrexone; Narcotic Antagonists; p38 Mitogen-Activated Protein Kinases; Pain Measurement; Pain Threshold; Pressure; Rats; Rats, Wistar; Spinal Cord; Syndrome; Thioxanthenes; Time Factors; Ubiquitin Thiolesterase; Xanthones | 2010 |
Pretreatment time with norbinaltorphimine.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Injections, Intraventricular; Injections, Spinal; Ischemic Preconditioning, Myocardial; Morphine; Naltrexone; Narcotic Antagonists; Rats; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2010 |
Effectiveness of analogs of the kappa opioid receptor antagonist (3R)-7-hydroxy-N-((1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JDTic) to reduce U50,488-induced diure
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cocaine-Related Disorders; Diuresis; Dose-Response Relationship, Drug; Male; Naltrexone; Pain; Piperidines; Rats; Rats, Long-Evans; Receptors, Opioid, kappa; Self Administration; Tetrahydroisoquinolines | 2010 |
The effects of acute restraint stress on nociceptive responses evoked by the injection of formalin into the temporomandibular joint of female rats.
Topics: Acute Disease; Animals; Behavior, Animal; Estrus; Female; Formaldehyde; Naltrexone; Narcotic Antagonists; Nociceptors; Pain; Pain Measurement; Proestrus; Rats; Rats, Wistar; Receptors, Opioid; Restraint, Physical; Stress, Physiological; Temporomandibular Joint; Temporomandibular Joint Disorders | 2010 |
Evidence for a role of opioids in epoxyeicosatrienoic acid-induced cardioprotection in rat hearts.
Topics: 8,11,14-Eicosatrienoic Acid; Analgesics, Opioid; Animals; Disease Models, Animal; GTP-Binding Protein alpha Subunits, Gi-Go; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Somatostatin | 2010 |
Endogenous kappa-opioid mediation of stress-induced potentiation of ethanol-conditioned place preference and self-administration.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Conditioning, Psychological; Enkephalins; Ethanol; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Naltrexone; Protein Precursors; Receptors, Opioid, kappa; Reward; Self Administration; Signal Transduction; Stress, Physiological | 2010 |
Targeting opioid receptors: A new treatment for brain disorders.
Topics: Animals; Antidepressive Agents; Anxiety Disorders; Brain; Depressive Disorder; Disease Models, Animal; Humans; Limbic System; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred WKY; Receptors, Opioid, kappa | 2010 |
Behavioral stress may increase the rewarding valence of cocaine-associated cues through a dynorphin/kappa-opioid receptor-mediated mechanism without affecting associative learning or memory retrieval mechanisms.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analysis of Variance; Anesthetics, Local; Animals; Association Learning; Behavior, Animal; Cocaine; Conditioning, Operant; Cues; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Dynorphins; Exploratory Behavior; Male; Mental Recall; Mice; Mice, Inbred C57BL; Naltrexone; Narcotic Antagonists; Receptors, Opioid, kappa; Reward; Stress, Psychological; Swimming | 2010 |
Effect of acute topical application of +-pentazocine on the mechanical allodynia in diabetic mice.
Topics: Administration, Topical; Animals; Diabetes Complications; Ethylenediamines; Male; Mice; Mice, Inbred ICR; Naltrexone; Nitric Oxide; Pentazocine; Receptors, Opioid, kappa; Receptors, sigma; Sigma-1 Receptor | 2010 |
Systemic κ-opioid receptor antagonism by nor-binaltorphimine reduces dependence-induced excessive alcohol self-administration in rats.
Topics: Administration, Inhalation; Alcohol Deterrents; Alcoholism; Animals; Dose-Response Relationship, Drug; Dynorphins; Ethanol; Injections, Subcutaneous; Male; Naltrexone; Narcotic Antagonists; Premedication; Rats; Rats, Wistar; Receptors, Opioid, kappa; Self Administration; Substance Withdrawal Syndrome | 2011 |
Attenuation of cannabinoid-induced inhibition of medullary dorsal horn neurons by a kappa-opioid receptor antagonist.
Topics: Animals; Benzoxazines; Calcium Channel Blockers; Cannabinoids; Dronabinol; Male; Medulla Oblongata; Morpholines; Naltrexone; Naphthalenes; Narcotic Antagonists; Patch-Clamp Techniques; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa | 2010 |
Sex-specificity and estrogen-dependence of kappa opioid receptor-mediated antinociception and antihyperalgesia.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Area Under Curve; Dose-Response Relationship, Drug; Estradiol; Estrous Cycle; Female; Inflammation; Injections, Spinal; Lumbosacral Region; Male; Naltrexone; Orchiectomy; Ovariectomy; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reverse Transcriptase Polymerase Chain Reaction; Sex Characteristics; Spinal Cord; Testosterone | 2010 |
Exposure to cocaine alters dynorphin-mediated regulation of excitatory synaptic transmission in nucleus accumbens neurons.
Topics: Animals; Cocaine; Drug Interactions; Dynorphins; Excitatory Postsynaptic Potentials; Male; Naltrexone; Neurons; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Synaptic Transmission | 2011 |
U50,488H postconditioning reduces apoptosis after myocardial ischemia and reperfusion.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Androstadienes; Animals; Apoptosis; Cardiotonic Agents; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Naltrexone; Narcotic Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Phosphoinositide-3 Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Wortmannin | 2011 |
[The study of effects and mechanism of U50, 488H on electrical coupling during ischemia in the perfused isolated rat heart].
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzophenanthridines; Connexin 43; Female; Heart; In Vitro Techniques; Myocardial Ischemia; Myocardium; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Signal Transduction | 2010 |
Opioid mediation of amniotic fluid effects on chemosensory responsiveness in the neonatal rat.
Topics: Administration, Oral; Amniotic Fluid; Analysis of Variance; Animals; Animals, Newborn; Animals, Suckling; Behavior, Animal; Female; Male; Milk; Motor Activity; Naltrexone; Narcotic Antagonists; Opioid Peptides; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Stimulation, Chemical | 2010 |
[Delayed electrical uncoupling is involved in kappa-opioid receptor activation -induced cardioprotective effect in the isolated rat heart].
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Antihypertensive Agents; Heart; In Vitro Techniques; Male; Myocardial Ischemia; Myocardium; Naltrexone; Potassium Channels; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa | 2006 |
μ-Opioid receptors in the nucleus accumbens shell region mediate the effects of amphetamine on inhibitory control but not impulsive choice.
Topics: Amphetamine; Analgesics, Opioid; Animals; Attention; Central Nervous System Stimulants; Choice Behavior; Conditioning, Operant; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Impulsive Behavior; Inhibition, Psychological; Male; Motivation; Naloxone; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Peptides; Rats; Rats, Wistar; Reaction Time; Receptors, Opioid, mu; Reinforcement Schedule | 2011 |
Differential expression and sensitivity of presynaptic and postsynaptic opioid receptors regulating hypothalamic proopiomelanocortin neurons.
Topics: Analgesics; Analgesics, Opioid; Analysis of Variance; Animals; Benzeneacetamides; Dizocilpine Maleate; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Gene Expression; Hypothalamus; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Luminescent Proteins; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Transgenic; Naltrexone; Narcotic Antagonists; Neural Inhibition; Neurons; Patch-Clamp Techniques; Peptide Fragments; Pro-Opiomelanocortin; Pyrrolidines; Quinoxalines; Receptors, Opioid; Somatostatin; Synapses | 2011 |
Morphine postconditioning attenuates ICAM-1 expression on endothelial cells.
Topics: Animals; Benzophenanthridines; Endothelial Cells; Endothelium, Vascular; Humans; Intercellular Adhesion Molecule-1; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Protein Isoforms; Protein Kinase C; Receptors, Opioid; Reperfusion Injury; Signal Transduction; Umbilical Veins | 2011 |
Delayed postoperative latent pain sensitization revealed by the systemic administration of opioid antagonists in mice.
Topics: Animals; Dizocilpine Maleate; Dynorphins; Hyperalgesia; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Pain Threshold; Piperidines; Postoperative Complications; Reaction Time; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa; Remifentanil; Spinal Cord | 2011 |
Ketanserin potentiates morphine-induced antinociception mediated by kappa-receptor activation.
Topics: Adrenergic alpha-1 Receptor Antagonists; Analgesics; Animals; Dose-Response Relationship, Drug; Drug Synergism; Ketanserin; Male; Mice; Mice, Inbred Strains; Morphine; Naltrexone; Pain; Pain Measurement; Pain Threshold; Prazosin; Pyrrolidines; Receptors, Adrenergic, alpha-1; Receptors, Opioid, kappa; Receptors, Serotonin, 5-HT2; Serotonin Antagonists | 2011 |
Local kappa opioid receptor activation decreases temporomandibular joint inflammation.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Movement; Dose-Response Relationship, Drug; Formaldehyde; Inflammation; Male; Naltrexone; Neutrophil Infiltration; Neutrophils; Rats; Rats, Wistar; Receptors, Opioid, kappa; Temporomandibular Joint | 2012 |
Inhibitory effects of processed Aconiti tuber on morphine-induced conditioned place preference in rats.
Topics: Aconitum; Animals; Behavior, Addictive; Behavior, Animal; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Tolerance; Drugs, Chinese Herbal; Dynorphins; Male; Morphine Dependence; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Phytotherapy; Plant Tubers; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa | 2011 |
Synergism between dexketoprofen and meloxicam in an orofacial formalin test was not modified by opioid antagonists.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Facial Pain; Formaldehyde; Ketoprofen; Male; Meloxicam; Mice; Naltrexone; Narcotic Antagonists; Stereoisomerism; Thiazines; Thiazoles | 2011 |
Activation of κ opioid receptors increases intrinsic excitability of dentate gyrus granule cells.
Topics: 4-Aminopyridine; Action Potentials; Animals; Benzeneacetamides; Dentate Gyrus; Dynorphins; GTP-Binding Proteins; Guanosine Diphosphate; Male; Mice; Mice, 129 Strain; Naltrexone; Neurons; Patch-Clamp Techniques; Potassium Channels; Pyrrolidines; Receptors, Opioid, kappa; Thionucleotides | 2011 |
Kappa opioid receptor localization and coupling to nitric oxide production in cells of the anterior chamber.
Topics: Analgesics; Animals; Cells, Cultured; Ciliary Body; Endothelium, Corneal; Enzyme Inhibitors; Estradiol; Humans; Intraocular Pressure; Male; Naltrexone; Narcotic Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pyrrolidines; Rabbits; Receptors, Opioid, kappa; Trabecular Meshwork | 2011 |
Acupuncture alleviates the affective dimension of pain in a rat model of inflammatory hyperalgesia.
Topics: Affect; Animals; Avoidance Learning; Conditioning, Classical; Disease Models, Animal; Electroacupuncture; Freund's Adjuvant; Gyrus Cinguli; Hyperalgesia; Inflammation; Male; Naltrexone; Pain Management; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin | 2011 |
The action of a synthetic derivative of Met5-enkephalin-Arg6-Phe7 on behavioral and endocrine responses.
Topics: Animals; Behavior, Animal; Enkephalin, Methionine; Enkephalins; Hypothalamo-Hypophyseal System; Male; Mice; Mice, Inbred Strains; Naloxone; Naltrexone; Oligopeptides; Pituitary-Adrenal System | 2011 |
Blockade of kappa opioid receptors attenuates the development of depressive-like behaviors induced by cocaine withdrawal in rats.
Topics: Analysis of Variance; Animals; Cocaine; Conditioning, Operant; Depression; Disease Models, Animal; Dopamine Uptake Inhibitors; Drug Administration Routes; Immobility Response, Tonic; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid, kappa; Reinforcement Schedule; Self Administration; Substance Withdrawal Syndrome; Swimming; Time Factors | 2012 |
Central administration of neuronostatin induces antinociception in mice.
Topics: Acute Pain; Analgesics; Animals; Dose-Response Relationship, Drug; Immunohistochemistry; Infusions, Intraventricular; Male; Melanocyte-Stimulating Hormones; Mice; Models, Animal; Naloxone; Naltrexone; Narcotic Antagonists; Nociception; Peptide Hormones; Periaqueductal Gray; Proto-Oncogene Proteins c-fos; Receptor, Melanocortin, Type 3; Receptor, Melanocortin, Type 4 | 2011 |
Sex difference in κ-opioid receptor (KOPR)-mediated behaviors, brain region KOPR level and KOPR-mediated guanosine 5'-O-(3-[35S]thiotriphosphate) binding in the guinea pig.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Non-Narcotic; Animals; Brain; Cocaine; Dopamine Uptake Inhibitors; Female; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Male; Mice; Motor Activity; Movement; Naltrexone; Narcotic Antagonists; Posture; Rats; Receptors, Opioid, kappa; Sex Characteristics | 2011 |
The effects of opioid receptor antagonists on electroacupuncture-produced anti-allodynia/hyperalgesia in rats with paclitaxel-evoked peripheral neuropathy.
Topics: Analysis of Variance; Animals; Antineoplastic Agents, Phytogenic; Disease Models, Animal; Electroacupuncture; Hyperalgesia; Male; Naltrexone; Narcotic Antagonists; Paclitaxel; Pain Measurement; Pain Threshold; Peripheral Nervous System Diseases; Random Allocation; Rats; Rats, Sprague-Dawley; Somatostatin | 2011 |
Opioidergic modulation of ethanol self-administration in the ventral pallidum.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Alcohol Drinking; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Globus Pallidus; Male; Microinjections; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Self Administration; Somatostatin | 2012 |
Opioid-like antinociceptive effects of oral administration of a lectin purified from the seeds of Canavalia brasiliensis.
Topics: Administration, Oral; Analgesics; Analgesics, Opioid; Animals; Canavalia; Mice; Morphinans; Naloxone; Naltrexone; Nociception; Pain Measurement; Plant Lectins; Receptors, Opioid, delta; Receptors, Opioid, kappa; Seeds | 2013 |
Salvinorin A has antiinflammatory and antinociceptive effects in experimental models of colitis in mice mediated by KOR and CB1 receptors.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Blotting, Western; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Diterpenes, Clerodane; Gastrointestinal Motility; Male; Mice; Naltrexone; Pain; Peroxidase; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Opioid, kappa; Salvia; Trinitrobenzenesulfonic Acid | 2012 |
Learning and memory impairment induced by salvinorin A, the principal ingredient of Salvia divinorum, in wistar rats.
Topics: Animals; Attention; Avoidance Learning; Diterpenes, Clerodane; Hallucinogens; Inhibition, Psychological; Learning; Male; Maze Learning; Memory, Long-Term; Motor Activity; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid, kappa; Recognition, Psychology; Salvia | 2011 |
Kisspeptin signaling is indispensable for neurokinin B, but not glutamate, stimulation of gonadotropin secretion in mice.
Topics: Adamantane; Animals; Dipeptides; Follicle Stimulating Hormone; Galanin-Like Peptide; Glutamic Acid; Gonadotropin-Releasing Hormone; Gonadotropins; Hypogonadism; Kisspeptins; Luteinizing Hormone; Male; Mice; Mice, Knockout; Models, Neurological; Naltrexone; Neurokinin B; Peptide Fragments; Receptors, G-Protein-Coupled; Receptors, Kisspeptin-1; Receptors, N-Methyl-D-Aspartate; Receptors, Neuropeptide; Signal Transduction; Substance P; Testosterone | 2012 |
The role of endogenous dynorphin in ethanol-induced state-dependent CPP.
Topics: Animals; Central Nervous System Depressants; Conditioning, Operant; Drug Administration Schedule; Dynorphins; Enkephalins; Ethanol; Female; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Naltrexone; Narcotic Antagonists; Protein Precursors; Sex Factors; Time Factors | 2012 |
Early maternal separation affects ethanol-induced conditioning in a nor-BNI insensitive manner, but does not alter ethanol-induced locomotor activity.
Topics: Alcohol Deterrents; Alcohol Drinking; Alcoholism; Animals; Animals, Newborn; Appetitive Behavior; Behavior, Animal; Conditioning, Psychological; Dose-Response Relationship, Drug; Exploratory Behavior; Female; Male; Maternal Deprivation; Motor Activity; Naltrexone; Narcotic Antagonists; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reinforcement, Psychology; Severity of Illness Index | 2012 |
YFa and analogs: investigation of opioid receptors in smooth muscle contraction.
Topics: Acetylcholine; Analgesics, Opioid; Animals; Cholinergic Agonists; Dynorphins; Enkephalin, Methionine; Guinea Pigs; Ileum; Male; Mice; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists; Neurotransmitter Agents; Oligopeptides; Receptors, Opioid; Vas Deferens | 2011 |
Agonist-selective effects of opioid receptor ligands on cytosolic calcium concentration in rat striatal neurons.
Topics: Animals; beta-Endorphin; Buprenorphine; Calcium; Corpus Striatum; Cytosol; Fluorescent Dyes; Fura-2; Ligands; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Opioid | 2012 |
Early role of the κ opioid receptor in ethanol-induced reinforcement.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Central Nervous System Depressants; Conditioning, Classical; Dose-Response Relationship, Drug; Ethanol; Female; Guanidines; Male; Morphinans; Motor Activity; Naltrexone; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reinforcement, Psychology | 2012 |
Effect of κ-opioid receptor agonist on the growth of non-small cell lung cancer (NSCLC) cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Resistance, Neoplasm; ErbB Receptors; Gefitinib; Gene Expression; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Mutation, Missense; Naltrexone; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinazolines; Receptors, Opioid, kappa; Signal Transduction; STAT3 Transcription Factor | 2012 |
Structure of the human κ-opioid receptor in complex with JDTic.
Topics: Binding Sites; Crystallography, X-Ray; Diterpenes, Clerodane; Guanidines; Humans; Models, Molecular; Morphinans; Mutagenesis, Site-Directed; Naltrexone; Piperidines; Protein Conformation; Receptors, Adrenergic, beta-2; Receptors, CXCR4; Receptors, Opioid, kappa; Structure-Activity Relationship; Tetrahydroisoquinolines | 2012 |
Ontogenetic differences in ethanol's motivational properties during infancy.
Topics: Age Factors; Animals; Animals, Newborn; Avoidance Learning; Conditioning, Operant; Conditioning, Psychological; Ethanol; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Saccharin | 2012 |
Regulation of GABA and glutamate release from proopiomelanocortin neuron terminals in intact hypothalamic networks.
Topics: Adrenocorticotropic Hormone; Analgesics, Opioid; Animals; Channelrhodopsins; Excitatory Postsynaptic Potentials; Female; gamma-Aminobutyric Acid; Glutamic Acid; Hypothalamus; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Light; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Naltrexone; Narcotic Antagonists; Nerve Net; Neurons; Neurotransmitter Agents; Patch-Clamp Techniques; Peptides; Presynaptic Terminals; Pro-Opiomelanocortin; Quinoxalines | 2012 |
Central kappa opioid receptors modulate salt appetite in rats.
Topics: Angiotensin II; Animals; Appetite; Blood Pressure; Diuretics; Food Preferences; Furosemide; Injections, Intraventricular; Male; Microinjections; Motor Activity; Naltrexone; Narcotics; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, kappa; Signal Transduction; Sodium Chloride, Dietary | 2012 |
κ opioid regulation of anxiety-like behavior during acute ethanol withdrawal.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Alcoholism; Animals; Anxiety; Behavior, Animal; Ethanol; Male; Naltrexone; Rats; Rats, Wistar; Receptors, Opioid, kappa; Substance Withdrawal Syndrome | 2012 |
Effects of the kappa opioid receptor antagonist, norbinaltorphimine, on stress and drug-induced reinstatement of nicotine-conditioned place preference in mice.
Topics: Animals; Conditioning, Psychological; Disease Models, Animal; Extinction, Psychological; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Nicotine; Receptors, Opioid, kappa; Recurrence; Risk Factors; Self Administration; Smoking; Stress, Psychological | 2013 |
κ-Opioid receptors within the nucleus accumbens shell mediate pair bond maintenance.
Topics: Aggression; Animals; Arvicolinae; Autoradiography; Brain; Corticosterone; Dose-Response Relationship, Drug; Female; Male; Microinjections; Naloxone; Naltrexone; Nucleus Accumbens; Pair Bond; Peptide Fragments; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sex Characteristics; Somatostatin; Testosterone | 2012 |
Long-acting κ opioid antagonists nor-BNI, GNTI and JDTic: pharmacokinetics in mice and lipophilicity.
Topics: Animals; Biological Transport; Brain; Guanidines; Hydrophobic and Hydrophilic Interactions; Injections, Intraperitoneal; LLC-PK1 Cells; Male; Mice; Morphinans; Naltrexone; Narcotic Antagonists; Permeability; Piperidines; Receptors, Opioid, kappa; Swine; Tetrahydroisoquinolines | 2012 |
Dysregulation of kappa-opioid receptor systems by chronic nicotine modulate the nicotine withdrawal syndrome in an age-dependent manner.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Aging; Animals; Behavior, Animal; Dopamine; Dose-Response Relationship, Drug; Male; Naltrexone; Nicotine; Nucleus Accumbens; Rats; Rats, Wistar; Receptors, Opioid, kappa; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2012 |
Centrally administered apelin-13 induces depression-like behavior in mice.
Topics: Amino Acid Sequence; Animals; Apelin Receptors; Corticotropin-Releasing Hormone; Depression; Injections; Injections, Intraventricular; Intercellular Signaling Peptides and Proteins; Male; Mice; Motor Activity; Naloxone; Naltrexone; Peptide Fragments; Receptor, Angiotensin, Type 1; Receptors, Corticotropin-Releasing Hormone; Receptors, G-Protein-Coupled; Receptors, Opioid, kappa; Rotarod Performance Test; Single-Blind Method | 2012 |
The effects of κ-opioid receptor on stretch-induced electrophysiological changes in infarcted rat hearts.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Action Potentials; Animals; Arrhythmias, Cardiac; Electrophysiological Phenomena; Male; Myocardial Infarction; Naltrexone; Pressoreceptors; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa | 2013 |
Elucidation of the mechanisms of membranotropic effects of RU-1203 on ionic channels of Lymnaea stagnalis neurons.
Topics: Animals; Benzimidazoles; Calcium; Cells, Cultured; Ion Channels; Lymnaea; Naltrexone; Neurons; Potassium; Sodium | 2012 |
Analgesic properties of chimeric peptide based on morphiceptin and PFRTic-amide.
Topics: Analgesia; Analgesics, Opioid; Animals; Arginine; Dose-Response Relationship, Drug; Endorphins; Guinea Pigs; Male; Mice; Morphinans; Naloxone; Naltrexone; Neuropeptides; Opioid Peptides; Proline; Receptors, Neuropeptide; Tetrahydroisoquinolines; Time Factors | 2012 |
[Effect of mu- and kappa-opioid receptor antagonists on aggressiveness of male mice with repeated experience of aggression].
Topics: Aggression; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Injections, Subcutaneous; Male; Mice; Mice, Inbred C57BL; Naltrexone; Narcotic Antagonists; Peptide Fragments; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin | 2012 |
GPR54-dependent stimulation of luteinizing hormone secretion by neurokinin B in prepubertal rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Antihypertensive Agents; Bodily Secretions; Female; Kisspeptins; Luteinizing Hormone; Male; Naltrexone; Narcotic Antagonists; Neurokinin B; Peptide Fragments; Radioimmunoassay; Rats; Receptors, G-Protein-Coupled; Receptors, Kisspeptin-1; Receptors, Tachykinin; Substance P | 2012 |
Effects of κ- and μ-opioid agonists on cholinergic neurotransmission and contraction in isolated bovine trachealis.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetylcholine; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Atropine; Cattle; Drug Interactions; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; In Vitro Techniques; Muscarinic Agonists; Muscarinic Antagonists; Muscle Contraction; Naltrexone; Narcotic Antagonists; Pilocarpine; Receptors, Opioid, kappa; Receptors, Opioid, mu; Trachea; Tritium | 2013 |
Antinociceptive action of isolated mitragynine from Mitragyna Speciosa through activation of opioid receptor system.
Topics: Analgesics; Animals; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Male; Mice; Mice, Inbred ICR; Mitragyna; Naloxone; Naltrexone; Narcotic Antagonists; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Opioid; Secologanin Tryptamine Alkaloids | 2012 |
Vasculoprotective effect of U50,488H in rats exposed to chronic hypoxia: role of Akt-stimulated NO production.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Apoptosis; Cells, Cultured; Endothelium, Vascular; Hypoxia; In Vitro Techniques; Male; Models, Animal; Naltrexone; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphorylation; Proto-Oncogene Proteins c-akt; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa | 2013 |
Effects of a post-shock injection of the kappa opioid receptor antagonist norbinaltorphimine (norBNI) on fear and anxiety in rats.
Topics: Animals; Anxiety; Behavior, Animal; Fear; Injections, Subcutaneous; Male; Naltrexone; Rats; Receptors, Opioid, kappa | 2012 |
Effect of food restriction on cocaine locomotor sensitization in Sprague-Dawley rats: role of kappa opioid receptors.
Topics: Animals; Cocaine; Corticosterone; Dose-Response Relationship, Drug; Food Deprivation; Male; Motor Activity; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa | 2013 |
Stress produces aversion and potentiates cocaine reward by releasing endogenous dynorphins in the ventral striatum to locally stimulate serotonin reuptake.
Topics: Animals; Avoidance Learning; Brain; Cocaine; Corpus Striatum; Dopamine; Dynorphins; G-Protein-Coupled Receptor Kinase 3; Male; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Microinjections; Naltrexone; Narcotic Antagonists; Nicotine; Nucleus Accumbens; p38 Mitogen-Activated Protein Kinases; Raphe Nuclei; Receptors, Opioid, kappa; Reward; Serotonin; Serotonin Plasma Membrane Transport Proteins; Signal Transduction; Stress, Psychological; Substance Withdrawal Syndrome; Synaptosomes | 2012 |
Pentazocine inhibits norepinephrine transporter function by reducing its surface expression in bovine adrenal medullary cells.
Topics: Adrenal Medulla; Analgesics, Opioid; Animals; Cattle; Cell Line; Cell Membrane; Cells, Cultured; Ethylenediamines; Fluoxetine; Gene Expression; Humans; Naltrexone; Narcotic Antagonists; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Pentazocine; Radionuclide Imaging | 2013 |
Chemical neuroanatomical and psychopharmacological evidence that κ receptor-mediated endogenous opioid peptide neurotransmission in the dorsal and ventral mesencephalon modulates panic-like behaviour.
Topics: Animals; Electric Stimulation; gamma-Aminobutyric Acid; Instinct; Male; Mesencephalon; Naltrexone; Neuroanatomy; Neurons; Opioid Peptides; Panic; Psychopharmacology; Rats; Rats, Wistar; Receptors, Opioid, kappa; Substantia Nigra; Synaptic Transmission | 2013 |
Kappa opioid receptors regulate stress-induced cocaine seeking and synaptic plasticity.
Topics: Animals; Cocaine-Related Disorders; Dopaminergic Neurons; Drug-Seeking Behavior; Extinction, Psychological; In Vitro Techniques; Long-Term Potentiation; Microinjections; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, GABA; Receptors, Opioid, kappa; Recurrence; Self Administration; Stress, Psychological; Swimming; Synapses; Ventral Tegmental Area | 2013 |
Prefrontal cortical kappa-opioid receptor modulation of local neurotransmission and conditioned place aversion.
Topics: Analgesics; Animals; Avoidance Learning; Benzeneacetamides; Dicarboxylic Acids; Dopamine; Drug Interactions; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Glutamic Acid; Male; Mice; Mice, Knockout; Microinjections; Miniature Postsynaptic Potentials; Naltrexone; Narcotic Antagonists; Neurotransmitter Uptake Inhibitors; Prefrontal Cortex; Pyramidal Cells; Pyrrolidines; Rats; Receptors, Opioid, kappa; Synaptic Transmission | 2013 |
Effects of co-administration of intrathecal nociceptin/orphanin FQ and opioid antagonists on formalin-induced pain in rats.
Topics: Analgesics; Animals; Formaldehyde; Injections, Spinal; Male; Naltrexone; Narcotic Antagonists; Nociceptin; Opioid Peptides; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid | 2013 |
Role of the endogenous opioid system in modulation of urinary bladder activity by spinal nerve stimulation.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Electric Stimulation; Female; Morphine; Muscle Contraction; Naltrexone; Narcotic Antagonists; Neural Inhibition; Opioid Peptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Spinal Nerves; Time Factors; Urinary Bladder; Urination | 2013 |
Ventral hippocampal kappa opioid receptors mediate the renewal of fear following extinction in the rat.
Topics: Animals; Extinction, Psychological; Fear; Hippocampus; Male; Naltrexone; Narcotic Antagonists; Rats; Receptors, Opioid, kappa | 2013 |
Dissociable effects of kappa-opioid receptor activation on impulsive phenotypes in wistar rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Conditioning, Operant; Dose-Response Relationship, Drug; Impulsive Behavior; Infusions, Intraventricular; Male; Naltrexone; Narcotic Antagonists; Phenotype; Rats; Receptors, Opioid, kappa | 2013 |
Synthesis, modeling, and pharmacological evaluation of UMB 425, a mixed μ agonist/δ antagonist opioid analgesic with reduced tolerance liabilities.
Topics: Analgesics, Opioid; Animals; CHO Cells; Computer Simulation; Cricetulus; Drug Evaluation, Preclinical; Drug Tolerance; Humans; Male; Mice; Models, Chemical; Molecular Structure; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptive Pain; Pain Measurement; Protein Binding; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship; Thebaine; Transfection | 2013 |
Protracted withdrawal from ethanol and enhanced responsiveness stress: regulation via the dynorphin/kappa opioid receptor system.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Alcoholism; Analgesics, Non-Narcotic; Animals; Anxiety; Dose-Response Relationship, Drug; Dynorphins; Ethanol; Male; Maze Learning; Motor Activity; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid, kappa; Stress, Psychological; Substance Withdrawal Syndrome | 2013 |
Effects of the kappa opioid receptor antagonist, nor-binaltorphimine, on ethanol intake: impact of age and sex.
Topics: Age Factors; Alcohol Drinking; Animals; Conditioning, Operant; Drinking Behavior; Ethanol; Female; Male; Naltrexone; Narcotic Antagonists; Rats; Self Administration; Sex Factors | 2014 |
Locus coeruleus kappa-opioid receptors modulate reinstatement of cocaine place preference through a noradrenergic mechanism.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic alpha-2 Receptor Agonists; Adrenergic beta-1 Receptor Antagonists; Adrenergic beta-Antagonists; Animals; Betaxolol; Clonidine; Cocaine; Conditioning, Psychological; Drug-Seeking Behavior; Locus Coeruleus; Male; Mice; Mice, Inbred C57BL; Naltrexone; Propanolamines; Propranolol; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Receptors, Opioid, kappa | 2013 |
A novel, potent, oral active and safe antinociceptive pyrazole targeting kappa opioid receptors.
Topics: Adrenergic alpha-2 Receptor Antagonists; Analgesics; Animals; Benzofurans; Diterpenes; Drug Administration Routes; Drug Evaluation, Preclinical; Idazoxan; Male; Mice; Molecular Structure; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Pyrazoles; Pyrrolidines; Radioligand Assay; Receptors, Opioid, kappa; Tritium; TRPV Cation Channels | 2013 |
Behavioral and neurochemical characterization of kratom (Mitragyna speciosa) extract.
Topics: Administration, Oral; Animals; Anxiety; Behavior, Animal; Blotting, Western; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; HEK293 Cells; Hot Temperature; Humans; Injections, Intraperitoneal; Injections, Intraventricular; Mice; Mice, Knockout; Mitragyna; Naltrexone; Narcotic Antagonists; Pain Threshold; Plant Extracts; Receptors, Dopamine D1; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2014 |
Physical presence of nor-binaltorphimine in mouse brain over 21 days after a single administration corresponds to its long-lasting antagonistic effect on κ-opioid receptors.
Topics: Analgesics; Animals; Benzeneacetamides; Brain; Chromatography, High Pressure Liquid; Hot Temperature; Injections, Intraventricular; Membranes; Mice; Mice, Inbred C57BL; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Pyrrolidines; Receptors, Opioid, kappa; Reference Standards; Tandem Mass Spectrometry; Time Factors | 2013 |
Chronic peripheral administration of kappa-opioid receptor antagonist advances puberty onset associated with acceleration of pulsatile luteinizing hormone secretion in female rats.
Topics: Animals; Drug Implants; Dynorphins; Female; Luteinizing Hormone; Naltrexone; Narcotic Antagonists; Nerve Tissue Proteins; Neurokinin B; Neurons; Ovary; Peptide Fragments; Puberty, Precocious; Random Allocation; Rats; Rats, Wistar; Receptors, Neurokinin-3; Receptors, Opioid, kappa; Sexual Maturation; Signal Transduction; Substance P; Weaning | 2013 |
Pharmacokinetic evidence for the long-lasting effect of nor-binaltorphimine, a potent kappa opioid receptor antagonist, in mice.
Topics: Animals; Brain; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, kappa; Time Factors | 2013 |
Selective κ opioid antagonists nor-BNI, GNTI and JDTic have low affinities for non-opioid receptors and transporters.
Topics: Allosteric Regulation; Biological Transport; Caco-2 Cells; Calcium; Guanidines; Humans; Kinetics; Morphinans; Naltrexone; Narcotic Antagonists; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Piperidines; Protein Binding; Receptors, Adrenergic, alpha; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tetrahydroisoquinolines | 2013 |
Pain-related depression of the mesolimbic dopamine system in rats: expression, blockade by analgesics, and role of endogenous κ-opioids.
Topics: Analgesics, Opioid; Animals; Benzeneacetamides; Depression; Disease Models, Animal; Dopamine; Gene Expression Regulation; Ketoprofen; Lactic Acid; Male; Medial Forebrain Bundle; Morphine; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Pain; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Self Stimulation; Time Factors | 2014 |
Analgesia induced by 2- or 100-Hz electroacupuncture in the rat tail-flick test depends on the anterior pretectal nucleus.
Topics: Analgesia; Animals; Atropine; Bicuculline; Electroacupuncture; GABA-A Receptor Antagonists; Male; Mesencephalon; Methiothepin; Methysergide; Muscarinic Antagonists; Naloxone; Naltrexone; Narcotic Antagonists; Pain Management; Rats; Rats, Wistar; Serotonin Antagonists; Somatostatin | 2013 |
Upregulated dynorphin opioid peptides mediate alcohol-induced learning and memory impairment.
Topics: Animals; CA3 Region, Hippocampal; Central Nervous System Depressants; Dynorphins; Ethanol; Glutamic Acid; Hippocampus; Learning; Maze Learning; Memory; Microdialysis; Naltrexone; Narcotic Antagonists; Radioimmunoassay; Rats; Rats, Wistar; Receptors, Opioid, kappa; Synaptic Transmission; Up-Regulation | 2013 |
Involvement of spinal cord opioid mechanisms in the acute antinociceptive effect of hyperbaric oxygen in mice.
Topics: Acetic Acid; Analgesia; Animals; beta-Endorphin; Dynorphins; Enkephalin, Methionine; Hyperbaric Oxygenation; Injections, Spinal; Male; Mice; Naltrexone; Narcotic Antagonists; Spinal Cord | 2013 |
Involvement of spinal release of α-neo-endorphin on the antinociceptive effect of TAPA.
Topics: Analgesia; Analgesics, Opioid; Animals; Endorphins; Gene Expression; Immune Sera; Injections, Spinal; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Naloxone; Naltrexone; Narcotic Antagonists; Nociception; Oligopeptides; Protein Precursors; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord; Tail | 2013 |
Kappa opioid receptor activation decreases inhibitory transmission and antagonizes alcohol effects in rat central amygdala.
Topics: Amygdala; Animals; Benzeneacetamides; Dynorphins; Ethanol; Inhibitory Postsynaptic Potentials; Male; Naltrexone; Narcotic Antagonists; Patch-Clamp Techniques; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa | 2014 |
Dynorphins regulate the strength of social memory.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amygdala; Animals; Enkephalins; Hippocampus; Memory; Mice; Mice, Knockout; Naltrexone; Narcotic Antagonists; Protein Precursors; Receptors, Opioid, kappa; Recognition, Psychology; Social Behavior | 2014 |
Antinociceptive activity of a synthetic oxopyrrolidine-based compound, ASH21374, and determination of its possible mechanisms.
Topics: Analgesics; Analgesics, Opioid; Animals; Aspirin; Capsaicin; Cyclic GMP; Glutamic Acid; Male; Mice; Mice, Inbred BALB C; Morphine; Motor Activity; Naloxone; Naltrexone; Nitric Oxide; Pyrrolidines; Rats, Sprague-Dawley; Receptors, Opioid | 2013 |
Long-term antagonism of κ opioid receptors prevents escalation of and increased motivation for heroin intake.
Topics: Animals; Anxiety; Catheterization; Conditioning, Operant; Enkephalins; Heroin Dependence; Immunohistochemistry; Male; Motivation; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Protein Precursors; Rats; Rats, Wistar; Receptors, Opioid, kappa; Reinforcement Schedule; Self Administration; Substance Withdrawal Syndrome | 2013 |
Maternal isolation during the first two postnatal weeks affects novelty-induced responses and sensitivity to ethanol-induced locomotor activity during infancy.
Topics: Animals; Animals, Newborn; Dose-Response Relationship, Drug; Ethanol; Female; Male; Maternal Deprivation; Motor Activity; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Self Administration | 2014 |
Characterization of BU09059: a novel potent selective κ-receptor antagonist.
Topics: Animals; Cell Line, Tumor; CHO Cells; Cricetulus; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Guanidines; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Isoquinolines; Male; Mice; Mice, Inbred Strains; Molecular Structure; Morphinans; Naltrexone; Narcotic Antagonists; Nociception; Piperidines; Rats; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tetrahydroisoquinolines; Vas Deferens | 2014 |
[Analgesic properties of morpholinoethylimidazobenzimidazole derivative RU-1205].
Topics: Analgesics; Animals; Animals, Outbred Strains; Benzimidazoles; Butorphanol; Male; Mice; Morpholines; Naloxone; Naltrexone; Narcotic Antagonists; Nociception; Pain; Pain Measurement; Rats; Receptors, Opioid, kappa | 2013 |
Zyklophin, a short-acting kappa opioid antagonist, induces scratching in mice.
Topics: Animals; Benzeneacetamides; Dose-Response Relationship, Drug; Dynorphins; Injections, Subcutaneous; Male; Mice; Mice, Knockout; Naltrexone; Peptide Fragments; Pruritus; Pyrrolidines; Radioligand Assay; Receptors, Opioid, kappa | 2014 |
Role of the kappa-opioid receptor system in stress-induced reinstatement of nicotine seeking in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic alpha-2 Receptor Antagonists; Analgesics, Non-Narcotic; Animals; Conditioning, Operant; Drug Administration Schedule; Drug Interactions; Extinction, Psychological; Male; Naltrexone; Nicotine; Nicotinic Agonists; Rats; Rats, Long-Evans; Receptors, Opioid, kappa; Self Administration; Stress, Psychological; Tobacco Use Disorder; Yohimbine | 2014 |
Central antinociception induced by ketamine is mediated by endogenous opioids and μ- and δ-opioid receptors.
Topics: Aminopeptidases; Analgesics; Animals; Brain; Cinnamates; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hot Temperature; Ketamine; Leucine; Male; Mice; Morphine Derivatives; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptive Pain; Opioid Peptides; Pain Perception; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2014 |
Brief prenatal ethanol exposure alters behavioral sensitivity to the kappa opioid receptor agonist (U62,066E) and antagonist (Nor-BNI) and reduces kappa opioid receptor expression.
Topics: Alcohol Drinking; Animals; Brain Chemistry; Conditioning, Psychological; Ethanol; Female; Gene Expression; Male; Naltrexone; Pregnancy; Prenatal Exposure Delayed Effects; Pyrrolidines; Rats, Sprague-Dawley; Receptors, Opioid, kappa | 2014 |
Opioid receptors in the prelimbic cortex modulate restraint stress-induced cardiovascular responses in the rat.
Topics: Animals; Arterial Pressure; Body Temperature; Cerebral Cortex; Dose-Response Relationship, Drug; Heart Rate; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats, Wistar; Receptors, Opioid; Restraint, Physical; Stress, Psychological; Tachycardia | 2014 |
Opioid modulation of prolactin secretion induced by stress during late pregnancy. Role of ovarian steroids.
Topics: Analgesics, Opioid; Animals; Estradiol; Female; Mifepristone; Naloxone; Naltrexone; Narcotic Antagonists; Ovary; Pregnancy; Progesterone; Prolactin; Rats; Rats, Wistar; Steroids; Tamoxifen | 2014 |
Repeated stress exposure causes strain-dependent shifts in the behavioral economics of cocaine in rats.
Topics: Animals; Cocaine; Dopamine Uptake Inhibitors; Drug-Seeking Behavior; Economics, Behavioral; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred WKY; Rats, Wistar; Self Administration; Stress, Psychological; Swimming | 2015 |
Effects of peripheral and spinal κ-opioid receptor stimulation on the exercise pressor reflex in decerebrate rats.
Topics: Animals; Decerebrate State; Femoral Artery; Injections, Intra-Arterial; Injections, Spinal; Ligation; Male; Models, Animal; Naltrexone; Peripheral Nerves; Physical Conditioning, Animal; Pressoreceptors; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Spinal Nerves | 2014 |
The role of kappa opioid receptors in stress-induced reinstatement of alcohol seeking in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Behavior, Addictive; Behavior, Animal; Cues; Drug-Seeking Behavior; Ethanol; Male; Naltrexone; Narcotic Antagonists; Pyrimidines; Pyrroles; Rats; Rats, Long-Evans; Receptors, Corticotropin-Releasing Hormone; Receptors, Opioid, kappa; Self Administration; Stress, Physiological; Yohimbine | 2014 |
Opposite effects of neuropeptide FF on central antinociception induced by endomorphin-1 and endomorphin-2 in mice.
Topics: Adamantane; Animals; Benzeneacetamides; Dipeptides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Injections, Intraventricular; Male; Mice; Naltrexone; Nociception; Oligopeptides; Pyrrolidines | 2014 |
Effects of buprenorphine on behavioral tests for antidepressant and anxiolytic drugs in mice.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Behavior, Animal; Buprenorphine; Depression; Desipramine; Dopamine; Male; Mice; Mice, Inbred C57BL; Motor Activity; Naltrexone; Narcotics; Nucleus Accumbens; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Swimming | 2015 |
Activation of κ-opioid receptor exerts the glucose-homeostatic effect in streptozotocin-induced diabetic mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adiponectin; AMP-Activated Protein Kinases; Analgesics, Non-Narcotic; Animals; Blood Glucose; Blotting, Western; Diabetes Mellitus, Experimental; Gene Expression; Glucose Transporter Type 4; Homeostasis; Hyperglycemia; Insulin; Male; Mice, Inbred BALB C; Naltrexone; Narcotic Antagonists; Phosphorylation; Protein Transport; Receptors, Adiponectin; Receptors, Opioid, kappa; Reverse Transcriptase Polymerase Chain Reaction | 2015 |
Epigenetic regulation of spinal cord gene expression controls opioid-induced hyperalgesia.
Topics: Analgesics, Opioid; Animals; Antineoplastic Agents; Azepines; Benzamides; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Dynorphins; Epigenesis, Genetic; Gene Expression Regulation; Hydroxamic Acids; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Morphine; Naltrexone; Narcotic Antagonists; Pain Measurement; Spinal Cord; Vorinostat | 2014 |
Sustained pain-related depression of behavior: effects of intraplantar formalin and complete freund's adjuvant on intracranial self-stimulation (ICSS) and endogenous kappa opioid biomarkers in rats.
Topics: Analgesics, Opioid; Animals; Body Weight; Conditioning, Operant; Disease Models, Animal; Formaldehyde; Freund's Adjuvant; Hyperalgesia; Inhibition, Psychological; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Self Stimulation | 2014 |
κ-Opioid receptors are not necessary for the antidepressant treatment of neuropathic pain.
Topics: Animals; Antidepressive Agents, Tricyclic; Male; Mice, Inbred C57BL; Mice, Knockout; Naltrexone; Neuralgia; Nortriptyline; Receptors, Opioid, delta; Receptors, Opioid, kappa; Sciatic Nerve | 2015 |
Interaction of the adenosine A1 receptor agonist N6-cyclopentyladenosine and κ-opioid receptors in rat spinal cord nociceptive reflexes.
Topics: Adenosine; Animals; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Fentanyl; Inflammation; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Rats; Rats, Wistar; Receptors, Opioid, kappa; Reflex; Spinal Cord | 2014 |
The opioid system majorly contributes to preference for fat emulsions but not sucrose solutions in mice.
Topics: Administration, Oral; Animals; Behavior, Animal; Choice Behavior; Dietary Fats; Eating; Emulsions; Food Preferences; Male; Mice; Mice, Inbred BALB C; Naloxone; Naltrexone; Narcotic Antagonists; Phospholipids; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Soybean Oil; Sucrose | 2015 |
[κ-opioid receptor agonist U50, 488H attenuates myocardial ischemia-reperfusionvia modulating Toll-like receptor 4/nuclear factor-κB signaling in rat].
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Arrhythmias, Cardiac; Brugada Syndrome; Cardiac Conduction System Disease; Coronary Artery Disease; Down-Regulation; Heart Conduction System; Myocardial Infarction; Myocardial Ischemia; Myocardium; Naltrexone; NF-kappa B; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reperfusion Injury; Signal Transduction; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha | 2014 |
Effects of the kappa opioid receptor antagonist nor-binaltorphimine (nor-BNI) on cocaine versus food choice and extended-access cocaine intake in rhesus monkeys.
Topics: Analysis of Variance; Animals; Cocaine; Conditioning, Operant; Drug-Seeking Behavior; Food Preferences; Macaca mulatta; Male; Naltrexone; Narcotic Antagonists; Receptors, Opioid, kappa; Self Administration | 2016 |
The kappa-opioid receptor antagonist, nor-binaltorphimine (nor-BNI), decreases morphine withdrawal and the consequent conditioned place aversion in rats.
Topics: Animals; Conditioning, Psychological; Defecation; Dynorphins; Male; Morphine; Morphine Dependence; Motor Activity; Naltrexone; Narcotic Antagonists; Narcotics; Neurotransmitter Agents; Random Allocation; Rats, Long-Evans; Receptors, Opioid, kappa; Spatial Behavior; Substance Withdrawal Syndrome | 2015 |
Potency enhancement of the κ-opioid receptor antagonist probe ML140 through sulfonamide constraint utilizing a tetrahydroisoquinoline motif.
Topics: Animals; Arrestins; Benzamides; beta-Arrestins; Chemistry Techniques, Synthetic; CHO Cells; Cricetulus; Drug Evaluation, Preclinical; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Naltrexone; Narcotic Antagonists; Receptors, Opioid, kappa; Structure-Activity Relationship; Sulfonamides; Tetrahydroisoquinolines | 2015 |
κ Opioid receptors in the nucleus accumbens shell mediate escalation of methamphetamine intake.
Topics: Analysis of Variance; Animals; Central Nervous System Stimulants; Conditioning, Operant; Enkephalins; Male; Methamphetamine; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Protein Precursors; Rats; Rats, Wistar; Receptors, Opioid, kappa; Reinforcement, Psychology; Self Administration | 2015 |
κ-Opioid receptors are involved in enhanced cardioprotection by combined fentanyl and limb remote ischemic postconditioning.
Topics: Animals; Extremities; Fentanyl; Ischemic Postconditioning; Male; Myocardial Reperfusion Injury; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa | 2015 |
High-dose pentazocine antagonizes the antinociception induced by high-dose morphine.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred C57BL; Morphine; Naltrexone; Pain; Pentazocine; Receptors, Opioid, kappa | 2015 |
Prefrontal Cortical Kappa Opioid Receptors Attenuate Responses to Amygdala Inputs.
Topics: Analgesics, Opioid; Animals; Anti-Anxiety Agents; Anxiety; Basolateral Nuclear Complex; Benzeneacetamides; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; Male; Mice, Inbred C57BL; Microelectrodes; Naltrexone; Narcotic Antagonists; Neural Pathways; Optogenetics; Prefrontal Cortex; Pyrrolidines; Random Allocation; Rats, Long-Evans; Receptors, Opioid, kappa | 2015 |
Effect of norbinaltorphimine on ∆⁹-tetrahydrocannabinol (THC)-induced taste avoidance in adolescent and adult Sprague-Dawley rats.
Topics: Aging; Animals; Appetite Stimulants; Avoidance Learning; Dose-Response Relationship, Drug; Dronabinol; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Taste; Taste Perception | 2015 |
Antagonism of κ opioid receptor in the nucleus accumbens prevents the depressive-like behaviors following prolonged morphine abstinence.
Topics: Animals; Antidepressive Agents; Depressive Disorder; Disease Models, Animal; Dose-Response Relationship, Drug; Enkephalins; Male; Mice, Inbred C57BL; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Narcotics; Nucleus Accumbens; Protein Precursors; Receptors, Opioid, kappa; RNA, Messenger; Substance Withdrawal Syndrome | 2015 |
Dynorphin activation of kappa opioid receptor reduces neuronal excitability in the paraventricular nucleus of mouse thalamus.
Topics: Animals; Barium; Cations; Dose-Response Relationship, Drug; Dynorphins; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Guanosine Diphosphate; Membrane Potentials; Mice, Inbred C57BL; Naltrexone; Narcotic Antagonists; Neurons; Neurotransmitter Agents; Paraventricular Hypothalamic Nucleus; Patch-Clamp Techniques; Receptors, Opioid, kappa; Sexual Maturation; Thionucleotides; Tissue Culture Techniques | 2015 |
Maturational alterations in constitutive activity of medial prefrontal cortex kappa-opioid receptors in Wistar rats.
Topics: Age Factors; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Guanosine 5'-O-(3-Thiotriphosphate); Male; Naltrexone; Narcotic Antagonists; Prefrontal Cortex; Protein Binding; Radionuclide Imaging; Rats; Rats, Wistar; Receptors, Opioid, kappa; Somatostatin; Sulfur Isotopes | 2015 |
Investigation of the role of βarrestin2 in kappa opioid receptor modulation in a mouse model of pruritus.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Arrestins; beta-Arrestins; Chloroquine; Disease Models, Animal; Dose-Response Relationship, Drug; Guanidines; Isoquinolines; Male; Mice, Inbred C57BL; Mice, Knockout; Morphinans; Motor Activity; Naltrexone; Pruritus; Receptors, Opioid, kappa | 2015 |
Interaction of CRF and kappa opioid systems on GABAergic neurotransmission in the mouse central amygdala.
Topics: Animals; Central Amygdaloid Nucleus; Corticotropin-Releasing Hormone; gamma-Aminobutyric Acid; Inhibitory Postsynaptic Potentials; Mice, Inbred C57BL; Mice, Knockout; Miniature Postsynaptic Potentials; Naltrexone; Receptors, Corticotropin-Releasing Hormone; Receptors, Opioid, kappa; Synaptic Transmission | 2015 |
Role of µ, κ, and δ opioid receptors in tibial inhibition of bladder overactivity in cats.
Topics: Acetic Acid; Animals; Cats; Female; Male; Morphinans; Naloxone; Naltrexone; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tibial Nerve; Transcutaneous Electric Nerve Stimulation; Urinary Bladder, Overactive | 2015 |
Intrathecal morphine-3-glucuronide-induced nociceptive behavior via Delta-2 opioid receptors in the spinal cord.
Topics: Animals; Behavior, Animal; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Leucine; Injections, Spinal; Male; MAP Kinase Signaling System; Mice; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Nociception; Receptors, Opioid, delta; Spinal Cord | 2016 |
Kappa-opioid antagonism impairs forebrain-dependent associative learning: A trace eyeblink conditioning study.
Topics: Animals; Association Learning; Blinking; Conditioning, Eyelid; Dose-Response Relationship, Drug; Male; Mice, Inbred C57BL; Naltrexone; Narcotic Antagonists; Random Allocation; Receptors, Opioid, kappa; Somatosensory Cortex; Vibrissae | 2015 |
Goshajinkigan reduces bortezomib-induced mechanical allodynia in rats: Possible involvement of kappa opioid receptor.
Topics: Aconitum; Animals; Bortezomib; Drugs, Chinese Herbal; Hyperalgesia; Male; Naltrexone; Phytotherapy; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Tramadol | 2015 |
Two short-acting kappa opioid receptor antagonists (zyklophin and LY2444296) exhibited different behavioral effects from the long-acting antagonist norbinaltorphimine in mouse anxiety tests.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Dynorphins; Feeding Behavior; Male; Mice; Motor Activity; Naltrexone; Peptide Fragments; Proteins; Receptors, Opioid, kappa | 2016 |
Coactivation of μ- and κ-Opioid Receptors May Mediate the Protective Effect of Testosterone on the Development of Temporomandibular Joint Nociception in Male Rats.
Topics: Animals; Brain Stem; Facial Pain; Formaldehyde; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nociception; Nociceptive Pain; Orchiectomy; Rats; Rats, Wistar; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin; Temporomandibular Joint; Temporomandibular Joint Disorders; Testosterone; Trigeminal Caudal Nucleus | 2016 |
Early-Life Social Isolation Stress Increases Kappa Opioid Receptor Responsiveness and Downregulates the Dopamine System.
Topics: Animals; Dopamine; Ethanol; Male; Naltrexone; Nucleus Accumbens; Rats, Long-Evans; Receptors, Opioid, kappa; Social Isolation; Stress, Psychological | 2016 |
Kappa opioid receptor antagonism and chronic antidepressant treatment have beneficial activities on social interactions and grooming deficits during heroin abstinence.
Topics: Animals; Antidepressive Agents, Second-Generation; Behavior, Animal; Disease Models, Animal; Fluoxetine; Grooming; Heroin; Heroin Dependence; Male; Mice; Mice, Inbred C57BL; Naltrexone; Narcotic Antagonists; Receptors, Opioid, kappa; Social Behavior; Time; Treatment Outcome | 2017 |
Influence of dynorphin on estradiol- and cervical stimulation-induced prolactin surges in ovariectomized rats.
Topics: Animals; Dynorphins; Estradiol; Estrous Cycle; Female; Naltrexone; Narcotic Antagonists; Neurons; Ovariectomy; Prolactin; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa | 2016 |
The anxiolytic- and antidepressant-like effects of ATPM-ET, a novel κ agonist and μ partial agonist, in mice.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Avoidance Learning; Emotions; Exploratory Behavior; Hindlimb Suspension; Locomotion; Mice; Morphinans; Naltrexone; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2016 |
κ-Opioid Receptor Stimulation Improves Endothelial Function via Akt-stimulated NO Production in Hyperlipidemic Rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Aorta; Blood Glucose; Diet, High-Fat; Endothelial Cells; Human Umbilical Vein Endothelial Cells; Humans; Hyperlipidemias; Liver; Male; Naltrexone; Nitric Oxide; Nitric Oxide Synthase; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Signal Transduction | 2016 |
Effects of the psychotomimetic benzomorphan N-allylnormetazocine (SKF 10,047) on prepulse inhibition of startle in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Anisoles; Dose-Response Relationship, Drug; Hallucinogens; Male; Mice; Mice, Inbred C57BL; Naltrexone; Phenazocine; Prepulse Inhibition; Propylamines; Receptors, Opioid, kappa; Receptors, Phencyclidine; Receptors, sigma; Reflex, Startle; Sigma-1 Receptor; Stereoisomerism | 2016 |
The Role of κ Opioid Receptor in Brain Ischemia.
Topics: Animals; Apoptosis; Blotting, Western; Brain Ischemia; Disease Models, Animal; Diterpenes, Clerodane; Male; Mice; Mice, Inbred C57BL; Naltrexone; Receptors, Opioid, kappa; Reperfusion Injury | 2016 |
Opioid system mediated anti-nociceptive effect of agomelatine in mice.
Topics: Acetamides; Analgesics; Animals; Dose-Response Relationship, Drug; Injections, Intraventricular; Male; Mice; Motor Activity; Naloxone; Naltrexone; Pain; Pain Measurement; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Rotarod Performance Test | 2016 |
Long-Term Reduction of Kappa Opioid Receptor Function by the Biased Ligand, Norbinaltorphimine, Requires c-Jun N-Terminal Kinase Activity and New Protein Synthesis in Peripheral Sensory Neurons.
Topics: Animals; Dinoprostone; Enzyme Activation; Hyperalgesia; JNK Mitogen-Activated Protein Kinases; Ligands; Male; Naltrexone; Protein Biosynthesis; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Sensory Receptor Cells; Signal Transduction; Time Factors | 2016 |
Stress-Induced Reinstatement of Nicotine Preference Requires Dynorphin/Kappa Opioid Activity in the Basolateral Amygdala.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Basolateral Nuclear Complex; Clozapine; Conditioning, Operant; Drug-Seeking Behavior; Dynorphins; Extinction, Psychological; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Naltrexone; Narcotic Antagonists; Nicotine; Nicotinic Agonists; Proto-Oncogene Proteins c-fos; Receptors, Opioid, kappa; Reinforcement, Psychology; Yohimbine | 2016 |
Nor-Binaltorphimine Blocks the Adverse Effects of Morphine after Spinal Cord Injury.
Topics: Animals; Disease Models, Animal; Drug-Related Side Effects and Adverse Reactions; Male; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Narcotics; Nociception; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Recovery of Function; Spinal Cord Injuries | 2017 |
Age-dependent regulation of GABA transmission by kappa opioid receptors in the basolateral amygdala of Sprague-Dawley rats.
Topics: Aging; Animals; Basolateral Nuclear Complex; Benzeneacetamides; gamma-Aminobutyric Acid; Glutamic Acid; Inhibitory Postsynaptic Potentials; Male; Naltrexone; Pyrrolidines; Rats; Receptors, Opioid, kappa; Synaptic Transmission | 2017 |
The differential effects of low and high doses of apelin through opioid receptors on the blood pressure of rats with renovascular hypertension.
Topics: Animals; Antihypertensive Agents; Apelin; Benzophenanthridines; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hemodynamics; Hypertension, Renovascular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Protein Kinase C; Rats; Rats, Wistar; Receptors, Opioid | 2017 |
Mu and kappa opioid receptors of the periaqueductal gray stimulate and inhibit thermogenesis, respectively, during psychological stress in rats.
Topics: Animals; Body Temperature; Male; Naltrexone; Narcotic Antagonists; Oxygen Consumption; Pain; Periaqueductal Gray; Rats; Rats, Wistar; Receptors, Opioid, kappa; Stress, Psychological; Thermogenesis | 2017 |
Kappa opioid receptor antagonists: A possible new class of therapeutics for migraine prevention.
Topics: Animals; Male; Mice; Mice, Inbred C57BL; Migraine Disorders; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa | 2017 |
The effects of kratom on restraint-stress-induced analgesia and its mechanisms of action.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Male; Mice; Mice, Transgenic; Mitragyna; Naltrexone; Plant Extracts; Plant Leaves; Receptors, Opioid, mu; Restraint, Physical; Stress, Physiological | 2017 |
Restraint stress enhances alcohol intake in adolescent female rats but reduces alcohol intake in adolescent male and adult female rats.
Topics: Aging; Alcohol Drinking; Animals; Central Nervous System Depressants; Choice Behavior; Disease Models, Animal; Ethanol; Exploratory Behavior; Female; Male; Motor Activity; Naltrexone; Narcotic Antagonists; Rats, Wistar; Receptors, Opioid, kappa; Restraint, Physical; Risk-Taking; Sex Characteristics; Stress, Psychological | 2017 |
κ-Opioid Receptor Activation in Dopamine Neurons Disrupts Behavioral Inhibition.
Topics: Animals; Behavior, Animal; Compulsive Behavior; Disease Models, Animal; Dopaminergic Neurons; Dorsal Raphe Nucleus; Female; Inhibition, Psychological; Male; Mice; Mice, Inbred C57BL; Morphinans; Naltrexone; Narcotic Antagonists; Prefrontal Cortex; Receptors, Opioid, kappa; Reinforcement, Psychology; Spiro Compounds; Stress, Psychological; Ventral Tegmental Area | 2018 |
Effects of ICI204,448, naloxone methiodide and levocetirizine on the scratching behavior induced by a κ-opioid antagonist, nor-BNI, in ICR mice.
Topics: Animals; Behavior, Animal; Cetirizine; Male; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Narcotic Antagonists; Pyrrolidines; Quaternary Ammonium Compounds | 2017 |
Opioid receptors mediate inotropic and depressor effects of apelin in rats with 2K1C-induced chronic renovascular hypertension.
Topics: Animals; Apelin; Blood Pressure; Gene Expression Regulation; Hypertension; Intercellular Signaling Peptides and Proteins; Kidney Diseases; Male; Myocardial Contraction; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid | 2018 |
Effects of pharmacological manipulation of the kappa opioid receptors on the aversive effects of nicotine.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Avoidance Learning; Conditioning, Operant; Male; Naltrexone; Narcotic Antagonists; Nicotine; Rats; Rats, Wistar; Receptors, Opioid, kappa; Taste | 2018 |
Maintenance on naltrexone+amphetamine decreases cocaine-vs.-food choice in male rhesus monkeys.
Topics: Administration, Intravenous; Animals; Choice Behavior; Cocaine; Dextroamphetamine; Dose-Response Relationship, Drug; Drug Interactions; Food; Macaca mulatta; Male; Morphine; Naltrexone; Receptors, Opioid, mu; Reinforcement, Psychology; Self Administration | 2017 |
Dynorphin Counteracts Orexin in the Paraventricular Nucleus of the Thalamus: Cellular and Behavioral Evidence.
Topics: Animals; Behavior, Addictive; Cocaine; Cocaine-Related Disorders; Drug Interactions; Dynorphins; Excitatory Postsynaptic Potentials; Extinction, Psychological; Male; Microinjections; Miniature Postsynaptic Potentials; Naltrexone; Orexins; Paraventricular Hypothalamic Nucleus; Rats; Reward; Self Administration | 2018 |
Serotonin induces peripheral antinociception via the opioidergic system.
Topics: Analgesics; Animals; Cinnamates; Dinoprostone; Disease Models, Animal; Male; Mice; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Opioid Peptides; Pain; Receptors, Opioid; Serotonin | 2018 |
The Protective Effects of Κ-Opioid Receptor Stimulation in Hypoxic Pulmonary Hypertension Involve Inhibition of Autophagy Through the AMPK-MTOR Pathway.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; AMP-Activated Protein Kinases; Animals; Antihypertensive Agents; Apoptosis; Autophagy; Blood Pressure; Cell Proliferation; Cells, Cultured; Chloroquine; Disease Models, Animal; Hypertension, Pulmonary; Male; Myocytes, Smooth Muscle; Naltrexone; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Signal Transduction; TOR Serine-Threonine Kinases | 2017 |
Lateralized kappa opioid receptor signaling from the amygdala central nucleus promotes stress-induced functional pain.
Topics: Analgesics, Opioid; Animals; Capsaicin; Central Amygdaloid Nucleus; Dynorphins; Hypothalamus; Male; Medulla Oblongata; Morphine; Naltrexone; Narcotic Antagonists; Pain; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Stress, Physiological | 2018 |
Neurokinin B receptor agonist and Dynorphin receptor antagonist stimulated luteinizing hormone secretion in fasted male rodents.
Topics: Animals; Fasting; Luteinizing Hormone; Male; Naltrexone; Narcotic Antagonists; Neurokinin B; Peptide Fragments; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-3; Receptors, Opioid; Signal Transduction; Substance P | 2018 |
Role of dorsal hippocampus κ opioid receptors in contextual aversive memory consolidation in rats.
Topics: Analgesics, Opioid; Animals; Association; Avoidance Learning; Benzeneacetamides; Conditioning, Psychological; Electroshock; Freezing Reaction, Cataleptic; Hippocampus; Male; Memory Consolidation; Naltrexone; Narcotic Antagonists; Piperazines; Psychotropic Drugs; Pyrrolidines; Random Allocation; Rats, Wistar; Receptors, Opioid, kappa | 2018 |
Salvinorin A preserves cerebral pial artery autoregulation after forebrain ischemia via the PI3K/AKT/cGMP pathway.
Topics: Animals; Brain Ischemia; Cerebral Arteries; Chromones; Cyclic GMP; Disease Models, Animal; Diterpenes, Clerodane; Male; Morpholines; Naltrexone; NG-Nitroarginine Methyl Ester; Phosphatidylinositol 3-Kinases; Pia Mater; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction | 2018 |
κ-opioid receptor activation protects against myocardial ischemia-reperfusion injury via AMPK/Akt/eNOS signaling activation.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cell Line; Cell Survival; Male; Myocardial Reperfusion Injury; Myocytes, Cardiac; Naltrexone; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Proto-Oncogene Proteins c-akt; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Ribonucleotides; Signal Transduction; Troponin T | 2018 |
The Chemokine CCL4 (MIP-1β) Evokes Antinociceptive Effects in Mice: a Role for CD4
Topics: Analgesics; Animals; CD4-Positive T-Lymphocytes; Chemokine CCL4; Enkephalin, Methionine; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Nociception; Pain; Pain Measurement | 2019 |
Noradrenaline induces peripheral antinociception by endogenous opioid release.
Topics: Analgesics; Animals; Cinnamates; Dinoprostone; Dose-Response Relationship, Drug; Hyperalgesia; Leucine; Male; Morphine Derivatives; Naltrexone; Norepinephrine; Opioid Peptides; Pain Measurement; Prazosin; Propranolol; Rats; Yohimbine | 2018 |
Maladaptive behavioral regulation in alcohol dependence: Role of kappa-opioid receptors in the bed nucleus of the stria terminalis.
Topics: Alcoholism; Animals; Conditioning, Operant; Dynorphins; Ethanol; Gene Expression Regulation; Male; Maze Learning; Naltrexone; Rats; Receptors, Opioid, kappa; RNA, Messenger; Self Administration; Septal Nuclei; Substance Withdrawal Syndrome; Up-Regulation; Vocalization, Animal | 2018 |
Pharmacological Characterization of Dezocine, a Potent Analgesic Acting as a κ Partial Agonist and μ Partial Agonist.
Topics: Analgesics, Opioid; Animals; Bridged Bicyclo Compounds, Heterocyclic; CHO Cells; Cricetulus; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Female; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Nociception; Pain Measurement; Protein Binding; Receptors, Opioid, kappa; Receptors, Opioid, mu; Signal Transduction; Tetrahydronaphthalenes | 2018 |
Antagonism of μ-opioid receptors reduces sensation seeking-like behavior in mice.
Topics: Animals; Appetitive Behavior; Brain; Conditioning, Operant; Dose-Response Relationship, Drug; Exploratory Behavior; Male; Mice, Inbred C57BL; Morphinans; Motivation; Motor Activity; Naltrexone; Narcotic Antagonists; Random Allocation; Receptors, Opioid; Receptors, Opioid, mu; Reward | 2019 |
Dynorphin-kappa opioid receptor activity in the central amygdala modulates binge-like alcohol drinking in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Behavior, Animal; Binge Drinking; Central Amygdaloid Nucleus; Disease Models, Animal; Dynorphins; Genetic Techniques; Male; Mice; Mice, Inbred C57BL; Naltrexone; Receptors, Opioid, kappa | 2019 |
Kappa opioid signaling in the central nucleus of the amygdala promotes disinhibition and aversiveness of chronic neuropathic pain.
Topics: Animals; Central Amygdaloid Nucleus; Chronic Pain; Disease Models, Animal; Hyperalgesia; In Vitro Techniques; Male; Membrane Potentials; Naltrexone; Narcotic Antagonists; Neural Inhibition; Neuralgia; Neurons; Pain Threshold; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Signal Transduction; Synaptic Transmission | 2019 |
Possible involvement of the μ opioid receptor in the antinociception induced by sinomenine on formalin-induced nociceptive behavior in mice.
Topics: Administration, Oral; Analgesics; Animals; Dose-Response Relationship, Drug; Formaldehyde; Male; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morphinans; Naloxone; Naltrexone; Nociception; Receptors, Opioid, mu; Spinal Cord | 2019 |
κ-Opioid receptor stimulation reduces palmitate-induced apoptosis via Akt/eNOS signaling pathway.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Survival; Gene Expression Regulation; Human Umbilical Vein Endothelial Cells; Humans; Naltrexone; Narcotic Antagonists; Nitric Oxide Synthase Type III; Palmitic Acid; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Receptors, Opioid, kappa; RNA, Small Interfering; Signal Transduction | 2019 |
Suppression of Human Natural Killer Cells by Different Classes of Opioids.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Anesthesia; Buprenorphine; Enkephalin, D-Penicillamine (2,5)-; Fentanyl; Fluoresceins; Humans; Immunosuppression Therapy; K562 Cells; Killer Cells, Natural; Loperamide; Methadone; Morphinans; Morphine; Naloxone; Naltrexone; Succinimides; Toll-Like Receptor 4; Tramadol | 2019 |
Kappa opioid signaling in the right central amygdala causes hind paw specific loss of diffuse noxious inhibitory controls in experimental neuropathic pain.
Topics: Amygdala; Animals; Chronic Pain; Diffuse Noxious Inhibitory Control; Electrophysiological Phenomena; Functional Laterality; Hindlimb; Hyperalgesia; Ligation; Male; Naltrexone; Neuralgia; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Signal Transduction; Spinal Nerves | 2019 |
Combination of Clinically Utilized Kappa-Opioid Receptor Agonist Nalfurafine With Low-Dose Naltrexone Reduces Excessive Alcohol Drinking in Male and Female Mice.
Topics: Alcohol Deterrents; Alcohol Drinking; Alcohol-Related Disorders; Animals; Drug Evaluation, Preclinical; Drug Tolerance; Female; Male; Mice, Inbred C57BL; Morphinans; Naltrexone; Receptors, Opioid, kappa; Saccharin; Spiro Compounds; Sucrose | 2019 |
Stereochemistry and innate immune recognition: (+)-norbinaltorphimine targets myeloid differentiation protein 2 and inhibits toll-like receptor 4 signaling.
Topics: Animals; Astrocytes; Cell Differentiation; Cell Line; Cells, Cultured; Interleukin-1beta; Lymphocyte Antigen 96; Male; Mice; Microglia; Naltrexone; Protein Structure, Secondary; Rats; Rats, Sprague-Dawley; Signal Transduction; Stereoisomerism; Structure-Activity Relationship; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha | 2019 |
The Blockade of µ1- and κ-Opioid Receptors in the Inferior Colliculus Decreases the Expression of Panic Attack-Like Behaviours Induced by Chemical Stimulation of the Dorsal Midbrain.
Topics: Animals; Behavior, Animal; Bicuculline; Exploratory Behavior; GABA-A Receptor Antagonists; Inferior Colliculi; Male; Mesencephalon; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Panic; Rats; Rats, Wistar; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2019 |
Pharmacological evaluation underlying the antinociceptive activity of two new hybrids NSAIDs tetrahydropyran derivatives.
Topics: Adenosine Triphosphate; Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclic GMP; Cyclooxygenase Inhibitors; Dizocilpine Maleate; Formaldehyde; Glyburide; Humans; Male; Mice; Naloxone; Naltrexone; NG-Nitroarginine Methyl Ester; Pain; Pain Measurement; Potassium Channels; Prostaglandin-Endoperoxide Synthases; Receptors, N-Methyl-D-Aspartate; Signal Transduction | 2020 |
Kappa opioid agonists reduce oxycodone self-administration in male rhesus monkeys.
Topics: Analgesics, Opioid; Animals; Behavior, Addictive; Cocaine; Diterpenes, Clerodane; Dose-Response Relationship, Drug; Macaca mulatta; Male; Morphinans; Naltrexone; Narcotic Antagonists; Oxycodone; Receptors, Opioid, kappa; Reinforcement, Psychology; Self Administration; Spiro Compounds | 2020 |
κ-opioid receptor activation promotes mitochondrial fusion and enhances myocardial resistance to ischemia and reperfusion injury via STAT3-OPA1 pathway.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Apoptosis; Cells, Cultured; GTP Phosphohydrolases; Male; Mice, Inbred C57BL; Mitochondrial Dynamics; Myocardial Reperfusion Injury; Myocardium; Naltrexone; Narcotic Antagonists; Phosphorylation; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Signal Transduction; STAT3 Transcription Factor | 2020 |
Dipyrone is locally hydrolyzed to 4-methylaminoantipyrine and its antihyperalgesic effect depends on CB
Topics: Analgesics; Animals; Cannabinoid Receptor Antagonists; Carrageenan; Dipyrone; Hydrolysis; Hyperalgesia; Indoles; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats, Wistar; Receptor, Cannabinoid, CB2; Receptors, Opioid, kappa; Somatostatin | 2020 |
Delta and kappa opioid receptors on mouse sperm cells: Expression, localization and involvement on in vitro fertilization.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Blastocyst; Embryo, Mammalian; Embryonic Development; Enkephalin, D-Penicillamine (2,5)-; Fertilization in Vitro; Male; Mice; Naltrexone; Narcotic Antagonists; Oocytes; Receptors, Opioid, delta; Receptors, Opioid, kappa; Sperm Capacitation; Spermatozoa | 2020 |
Dynorphin and GABAA Receptor Signaling Contribute to Progesterone's Inhibition of the LH Surge in Female Mice.
Topics: Animals; Bicuculline; Dynorphins; Estradiol; Female; GABA Antagonists; Hypothalamus; Hypothalamus, Anterior; Kisspeptins; Luteinizing Hormone; Mice, Inbred C57BL; Naltrexone; Neurons; Organophosphorus Compounds; Ovariectomy; Progesterone; Receptors, GABA-A; Signal Transduction | 2020 |
The Role of Cardiac Opioid Receptors in the Cardioprotective Effect of Continuous Normobaric Hypoxia.
Topics: Adaptation, Physiological; Animals; Benzylidene Compounds; Creatine Kinase; Hypoxia; Male; Myocardial Reperfusion Injury; Myocardium; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Organ Culture Techniques; Peptides; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tetrahydroisoquinolines | 2020 |
Kappa opioid receptors internalization is protective against oxygen-glucose deprivation through β-arrestin activation and Akt-mediated signaling pathway.
Topics: Animals; Autophagy; beta-Arrestins; Cell Survival; Glucose; Mice; Naltrexone; Oxygen; Proto-Oncogene Proteins c-akt; Receptors, Opioid, kappa; Signal Transduction | 2020 |
Discovery of small molecules that normalize the transcriptome and enhance cysteine cathepsin activity in progranulin-deficient microglia.
Topics: Animals; Bucladesine; Cell Cycle; Cells, Cultured; Cysteine Proteases; Disease Models, Animal; Frontotemporal Dementia; Gene Expression Profiling; Gene Expression Regulation; Gene Knockout Techniques; High-Throughput Nucleotide Sequencing; Humans; Lysosomes; Mice; Microglia; Models, Biological; Naltrexone; Progranulins; Sequence Analysis, RNA; Small Molecule Libraries | 2020 |
Regulation of Kappa Opioid Receptor Inactivation Depends on Sex and Cellular Site of Antagonist Action.
Topics: Analgesics, Opioid; Animals; Dopamine; Dopaminergic Neurons; Female; Male; Mice; Mice, Inbred C57BL; Naltrexone; Narcotic Antagonists; Phosphorylation; Reactive Oxygen Species; Receptors, Opioid, kappa; Signal Transduction | 2020 |
The blockade of kappa opioid receptors exacerbates alveolar bone resorption in rats.
Topics: Alveolar Bone Loss; Animals; Bone Resorption; Cytokines; Disease Models, Animal; Male; Morphinans; Naltrexone; Narcotic Antagonists; Osteoblasts; Osteoclasts; Periodontitis; Rats; Rats, Wistar; Receptors, Opioid | 2020 |
A low pKa ligand inhibits cancer-associated pain in mice by activating peripheral mu-opioid receptors.
Topics: Analgesics, Opioid; Animals; Bone Neoplasms; Cancer Pain; Cell Line, Tumor; Fentanyl; Hydrogen-Ion Concentration; Hyperalgesia; Ligands; Male; Melanoma, Experimental; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Piperidines; Receptors, Opioid, mu | 2020 |
Effects of kappa opioid receptor agonists on fentanyl vs. food choice in male and female rats: contingent vs. non-contingent administration.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Female; Fentanyl; Male; Morphinans; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reinforcement, Psychology; Spiro Compounds | 2021 |
Naloxone-induced analgesia mediated by central kappa opioid system in chronic inflammatory pain.
Topics: Analgesia; Analgesics, Opioid; Animals; Chronic Pain; Inflammation Mediators; Male; Mice; Mice, Inbred C57BL; Microinjections; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, kappa | 2021 |
Antipruritic Effect of Nalbuphine, a Kappa Opioid Receptor Agonist, in Mice: A Pan Antipruritic.
Topics: Animals; Antipruritics; Behavior, Animal; Chloroquine; Deoxycholic Acid; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Mice; Nalbuphine; Naltrexone; Narcotic Antagonists; Pruritus; Receptors, Opioid, kappa; tat Gene Products, Human Immunodeficiency Virus | 2021 |
Blockade of kappa opioid receptors reduces mechanical hyperalgesia and anxiety-like behavior in a rat model of trigeminal neuropathic pain.
Topics: Animals; Anxiety; Central Amygdaloid Nucleus; Chronic Pain; Disease Models, Animal; Hyperalgesia; Male; Naltrexone; Nociception; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Trigeminal Neuralgia | 2022 |
14-3-3γ mediates the long-term inhibition of peripheral kappa opioid receptor antinociceptive signaling by norbinaltorphimine.
Topics: 14-3-3 Proteins; Analgesics; Animals; Cricetinae; Cricetulus; JNK Mitogen-Activated Protein Kinases; Naltrexone; Pain; Rats; Receptors, Opioid, kappa; RNA, Small Interfering | 2022 |