naltrexone has been researched along with naltrindole in 741 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (0.40) | 18.7374 |
| 1990's | 342 (46.15) | 18.2507 |
| 2000's | 255 (34.41) | 29.6817 |
| 2010's | 130 (17.54) | 24.3611 |
| 2020's | 11 (1.48) | 2.80 |
| Authors | Studies |
|---|---|
| Klein, P; Nelson, WL | 1 |
| Portoghese, PS | 2 |
| Lin, CE; MaloneyHuss, KE; Nagase, H; Portoghese, PS; Takemori, AE | 1 |
| Portoghese, PS; Sultana, M; Takemori, AE | 2 |
| Bell, GI; Chen, Y; Kong, H; Raynor, K; Reisine, T; Yasuda, K; Yu, L | 1 |
| Bell, GI; Breder, CD; Kong, H; Raynor, K; Reisine, T; Takeda, J; Yasuda, K | 1 |
| Adapa, ID; Auh, JS; Berzetei-Gurske, IP; Brandt, SR; Craymer, K; Farrington, L; Haggart, D; Kennedy, JM; O'Brien, A; Polgar, WE; Rodriguez, L; Schwartz, RW; Toll, L; White, A | 1 |
| Ananthan, S; Bilsky, EJ; Carter, RL; Davis, P; Dersch, CM; Kezar, HS; Porreca, F; Rice, KC; Rothman, RB; Saini, SK; Wells, JL; Xu, H | 1 |
| Strassburg, CP; Tukey, RH | 1 |
| Ferguson, DM; Metzger, TG; Paterlini, MG; Portoghese, PS | 2 |
| Grundt, P; Husbands, SM; Jales, AR; Lewis, JW; Traynor, JR | 1 |
| Grundt, P; Husbands, SM; Lewis, JW; Martinez-Bermejo, F | 1 |
| Ananthan, S; Bartlett, JL; Bilsky, EJ; Davis, P; Dersch, CM; Khare, NK; Porreca, F; Rothman, RB; Saini, SK; Seitz, LE | 1 |
| Grundt, P; Husbands, SM; Lewis, JW; Williams, IA | 1 |
| Aceto, MD; Husbands, SM; Lewis, JW; Miller, CN; Shefali, S; Srivastava, SK; Traynor, JR | 1 |
| Carroll, FI; Navarro, HA; Thomas, JB; Zhang, L | 1 |
| Hebbel, RP; Lunzer, MM; Portoghese, PS; Yekkirala, A | 1 |
| Aschenbach, LC; He, H; Li, G; Selley, DE; Zhang, Y | 1 |
| Bidlack, JM; Bu, Y; Cohen, DJ; Denhardt, C; Ganorkar, R; Guo, C; Jin, J; Lou, R; Lu, Q; VanAlstine, MA; Wentland, MP | 1 |
| Azar, MR; Cashman, JR; Ghirmai, S | 1 |
| Burgman, M; Grinnell, S; Haselton, N; Majumdar, S; Ocampo, J; Pasternak, AR; Pasternak, GW | 1 |
| Fujii, H; Kobayashi, S; Miyata, Y; Nagase, H; Osa, Y; Takeuchi, T | 1 |
| Beletskaya, IO; Elbegdorj, O; Selley, DE; Yuan, Y; Zhang, Y | 1 |
| Arnatt, CK; He, H; Kellogg, GE; Mosier, PD; Selley, DE; Zaidi, SA; Zhang, Y | 1 |
| Clark, MJ; Husbands, SM; Kumar, V; Lewis, JW; Traynor, JR | 1 |
| Iwata, S; Koyama, Y; Kutsumura, N; Miyata, Y; Nagase, H; Nagumo, Y; Nakajima, R; Saitoh, T; Yamamoto, N; Yoshida, N | 1 |
| Berggren, A; Rubenson, A; Sillén, U | 1 |
| Horvath, R; Hruby, VJ; Knapp, RJ; Malatynska, E; Otvos, F; Porreca, F; Toth, G; Yamamura, HI; Yamamura, MS | 1 |
| Akami, T; Arakawa, K; Matsumoto, S; Nagase, H; Oka, T; Okamoto, M | 1 |
| Akami, T; Arakawa, K; Matsumoto, S; Mitsuo, M; Nagase, H; Nakai, I; Nakajima, H; Oka, T; Okamoto, M | 1 |
| Nagase, H; Portoghese, PS; Sultana, M; Takemori, AE | 1 |
| Bourgoin, S; Cesselin, F; Collin, E; Ferhat, L; Hamon, M | 1 |
| Broccardo, M; Improta, G | 1 |
| Kamei, J; Kasuya, Y; Kawashima, N | 1 |
| Kamei, J; Kasuya, Y; Tanihara, H | 2 |
| Maier, SF; Watkins, LR; Wiertelak, EP | 2 |
| Holtzman, SG; Jones, DN | 1 |
| Hammond, DL; Rafferty, MF; Stapelfeld, A | 1 |
| Dickenson, AH; Kalso, EA; McQuay, HJ; Sullivan, AF | 1 |
| Cheng, PY; Cheng, Y; Decena, J; McCabe, S; Szeto, HH; Wu, DL | 1 |
| Dewey, WL; Smith, FL | 1 |
| De Vries, TJ; Hogenboom, F; Hruby, VJ; Mulder, AH; Portoghese, PS; Schoffelmeer, AN | 1 |
| Malmberg, AB; Yaksh, TL | 1 |
| Crook, TJ; Hill, RG; Kitchen, I | 1 |
| Freye, E; Latasch, L; Portoghese, PS | 1 |
| Larson, DL; Portoghese, PS; Sultana, M; Takemori, AE | 1 |
| Le, AD; Poulos, CX; Walker, MJ | 1 |
| Kameyama, T; Toyoshi, T; Ukai, M | 1 |
| Griffin, IJ; Jackson, HC; Nutt, DJ | 1 |
| Derrick, BE; Lieberman, DN; Martinez, JL; Rodriguez, SB | 1 |
| Adler, MW; Geller, EB; Handler, CM | 1 |
| Larson, AA; Mousseau, DD; Sun, X | 1 |
| Bilsky, EJ; Menkens, K; Porreca, F; Portoghese, PS; Reid, LD; Wild, KD | 1 |
| Kawabata, A; Nishimura, Y; Takagi, H | 1 |
| Fournié-Zaluski, MC; Noble, F; Roques, BP; Turcaud, S | 1 |
| Stamidis, H; Young, GA | 1 |
| Bourgoin, S; Cesselin, F; Collin, E; Hamon, M; Mantelet, S | 1 |
| Blalock, JE; Carr, DJ; DeCosta, BR; Radulescu, RT; Rice, KC | 2 |
| Misawa, M; Nagase, H; Narita, M; Suzuki, T | 3 |
| Carboni, E; Di Chiara, G; Garau, L; Longoni, R; Melchiorri, P; Mulas, A; Spina, L | 1 |
| Jackson, HC; Nutt, DJ | 2 |
| Calenco-Choukroun, G; Daugé, V; Féger, J; Gacel, G; Roques, BP | 1 |
| Abdelhamid, EE; Portoghese, PS; Sultana, M; Takemori, AE | 1 |
| Kaneto, H; Kawasaki, K; Kobayashi, Y; Maeda, M; Shimokawa, K; Taguchi, T; Takahashi, M; Tokuyama, S; Watanabe, J; Yamamoto, Y | 1 |
| de Costa, BR; Drower, EJ; Hammond, DL; Rafferty, MF; Rice, KC; Stapelfeld, A | 1 |
| Angelucci, F; Negri, L; Noviello, V | 1 |
| Song, ZH; Takemori, AE | 1 |
| Bourgoin, S; Cesselin, F; Chantrel, D; Collin, E; Hamon, M; Mauborgne, A | 1 |
| Burks, TF; Davis, TP; Greene, DL; Hersh, LB; Hruby, VJ; Kramer, TH; Sharma, SD; Weber, SJ; Yamamura, HI | 1 |
| Ayres, EA; Burks, TF; Fang, S; Hruby, VJ; Kramer, TH; Parkhurst, DN | 1 |
| Giordano, J; Hughes, RA; Sufka, KJ | 1 |
| Portoghese, PS; Sofuoglu, M; Takemori, AE | 1 |
| Baamonde, A; Daugé, V; Gacel, G; Roques, BP | 1 |
| Lawrence, AJ; Traynor, JR | 1 |
| Birch, PJ; Hayes, AG; Lawrence, AJ; Rogers, H; Traynor, JR | 1 |
| Calcagnetti, DJ; Holtzman, SG | 1 |
| Froimowitz, M | 1 |
| Fukagawa, Y; Misawa, M; Nagase, H; Suzuki, T | 2 |
| de Costa, BR; France, CP; Jacobson, AE; Rice, KC; Woods, JH | 1 |
| Chalmers, J; Drolet, G; Morilak, D | 1 |
| Kitchen, I; Pinker, SR | 1 |
| Kaneto, H; Senda, T; Takahashi, M; Tokuyama, S | 1 |
| Ayres, EA; Burks, TF; Davis, P | 1 |
| Jackson, HC; Nutt, DJ; Ripley, TL | 1 |
| Comer, S; DeCosta, B; France, CP; Jacobson, AE; Medzihradsky, F; Rice, KC; Smith, CB; Winger, G; Woods, JH | 1 |
| Laorden, ML; Llobell, F | 1 |
| Kalso, EA; Kontinen, VK | 1 |
| Froehlich, JC; Jing, SL; Krishnan-Sarin, S; Kurtz, DL; Li, TK; Portoghese, PS; Zweifel, M | 1 |
| Bilsky, EJ; French, ED; Glick, SD; Menkens, KA; Porreca, F; Reid, LD | 1 |
| Heidbreder, C; Shippenberg, TS | 1 |
| Kamei, J; Kasuya, Y; Saitoh, A | 1 |
| Goettl, VM; Larson, AA | 1 |
| Fukushima, N; Hayashi, C; Katayama, T; Misu, Y; Miyamae, T; Ueda, H | 1 |
| Goodman, M; Malmberg, AB; Ro, S; Schiller, P; Yaksh, TL | 1 |
| Misawa, M; Mori, T; Nagase, H; Suzuki, T; Tsuji, M | 3 |
| Kinter, CM; Lever, JR | 1 |
| Bodnar, RJ; Cole, JL; Kirkham, TC; Leventhal, L | 1 |
| Maggi, R; Martini, L; Pimpinelli, F; Piva, F | 1 |
| Knapp, RJ; Li, X; Malatynska, E; Roeske, WR; Santoro, G; Waite, S; Wang, Y; Yamamura, HI | 1 |
| Alsasua, A; Martín, MI; Parra, L; Pérez-Vizcaíno, F; Tamargo, J | 1 |
| Collins, KA; Henneberry, B; Tseng, LF | 1 |
| Shahabi, NA; Sharp, BM | 1 |
| Hitosugi, H; Kamei, J; Kasuya, Y | 1 |
| Devine, DP; Leone, P; Pocock, D; Wise, RA | 1 |
| Lai, J; Porreca, F; Vanderah, TW; Yamamura, HI | 1 |
| Bodnar, RJ; Glass, MJ; Koch, JE | 1 |
| Coupar, IM; Hancock, DL | 1 |
| Crisp, T; Keck, BJ; Stafinsky, JL; Uram, M | 1 |
| Bernstein, RN; Bilsky, EJ; Calderon, SN; Davis, P; Hruby, VJ; McNutt, RW; Porreca, F; Rice, KC; Rothman, RB; Wang, T | 1 |
| Kovelowski, CJ; Ossipov, MH; Porreca, F | 1 |
| Blommaert, A; Fournié-Zaluski, MC; Noble, F; Roques, BP | 1 |
| Corringer, PJ; Dauge, V; Roques, BP | 1 |
| Noble, F; Roques, BP | 1 |
| Lewis, DV; Xie, CW | 1 |
| Kromer, W | 1 |
| Kamei, J; Kasuya, Y; Misawa, M; Nagase, H; Suzuki, T | 1 |
| Aloyo, VJ; Pazdalski, PS | 1 |
| Angel, F; Baumann, R; Chamouard, P; Meyer, C; Rohr, S | 1 |
| Funada, M; Iwamoto, Y; Kamei, J; Kasuya, Y; Misawa, M; Nagase, H; Saitoh, A; Suzuki, T | 1 |
| Funada, M; Misawa, M; Mori, T; Nagase, H; Suzuki, T | 1 |
| Moerschbaecher, JM; Pakarinen, ED; Woods, JH | 1 |
| Farouz-Grant, F; Portoghese, PS; Sultana, M; Takemori, AE | 1 |
| Iwamoto, Y; Kamei, J; Kasuya, Y; Kawashima, N; Misawa, M; Nagase, H; Suzuki, T | 1 |
| Kamei, J; Misawa, M; Mizoguchi, H; Nagase, H; Suzuki, T; Yoshiike, M | 1 |
| Hitosugi, H; Kamei, J; Kasuya, Y; Misawa, M; Nagase, H | 1 |
| Funada, M; Misawa, M; Nagase, H; Narita, M; Suzuki, T | 1 |
| Cheng, PY; Soong, Y; Szeto, HH; Wu, DL | 1 |
| Planas, E; Pol, O; Puig, MM | 1 |
| Kovelowski, CJ; Ossipov, MH; Porreca, F; Vanderah, T | 1 |
| Búzás, B; Cox, BM; Izenwasser, S | 1 |
| Butelman, ER; DeCosta, BR; Walker, EA; Woods, JH | 1 |
| Goñalons, E; Jimenez, M; Martinez, V; Vergara, P | 1 |
| Connelly, CD; Martinez, RP; Porreca, F; Raffa, RB; Schupsky, JJ | 1 |
| de Costa, BR; Orlowski, M; Petrov, ES; Rice, KC; Robinson, SR; Smotherman, WP; Varlinskaya, EI | 1 |
| Guirimand, F; Le Bars, D; Strimbu-Gozariu, M; Willer, JC | 1 |
| Sheiner, LB; Troconiz, IF; Verotta, D | 1 |
| Buéno, L; Gué, M; Junien, JL | 1 |
| Butelman, ER; Chang, KJ; DeCosta, B; Negus, SS; Winger, G; Woods, JH | 1 |
| Wong, CL | 1 |
| Kameyama, T; Mizutani, M; Sasaki, Y; Toyoshi, T; Ukai, M | 1 |
| Schiller, PW; Wilkes, BC | 1 |
| Davis, T; Shah, S; Yoburn, BC | 1 |
| Benoliel, JJ; Bourgoin, S; Cesselin, F; Collin, E; Hamon, M; Mauborgne, A | 1 |
| Noble, F; Roques, BP; Smadja, C | 1 |
| Derrien, M; Durieux, C; Roques, BP | 1 |
| Moe, ST; Ohkawa, S; Portoghese, PS; Takemori, AE | 1 |
| Bell, GI; Kong, H; Raynor, K; Reisine, T; Takeda, J; Yano, H | 1 |
| Randich, A; Robertson, JD; Willingham, T | 1 |
| Inman, JD; Moss, IR; Scott, SC | 2 |
| Hammond, DL; Stewart, PE | 1 |
| Fang, L; Haaseth, RC; Horvath, R; Hruby, VJ; Knapp, RJ; Matsunaga, TO; Porreca, F; Yamamura, HI | 1 |
| Chow, S; Lê, AD; Poulos, CX; Quan, B | 1 |
| Moe, ST; Portoghese, PS; Sultana, M; Takemori, AE | 1 |
| Billington, CJ; Grace, MK; Kotz, CM; Levine, AS | 1 |
| Iwamoto, Y; Kamei, J; Kasuya, Y; Misawa, M; Mizuno, D; Nagase, H; Okutomi, T; Soma, G; Suzuki, T | 1 |
| Ludbrook, J; Ventura, S | 1 |
| Bodnar, RJ; Hahn, B; Koch, JE; Ruegg, H | 1 |
| Lendvai, B; Sándor, A; Sándor, NT | 1 |
| Billington, CJ; Grace, M; Levine, AS; Portoghese, PS | 1 |
| Carr, KD; Papadouka, V | 2 |
| Iwamoto, Y; Kamei, J; Kasuya, Y; Misawa, M; Nagase, H | 2 |
| Babin, E; Fang, L; Hruby, VJ; Knapp, RJ; Li, X; Malatynska, E; Nguyen, M; Roeske, WR; Santoro, G; Varga, EV | 1 |
| Kaneto, H; Takahashi, M; Tokuyama, S | 1 |
| Cattaneo, I; Guilbaud, G; Kayser, V | 1 |
| Borsodi, A; Chang, KJ; Fang, L; McNutt, RW; Porreca, F; Toth, G; Wild, KD; Yamamura, HI | 1 |
| Fukushima, N; Misu, Y; Miyamae, T; Ueda, H | 1 |
| Chang, KJ; Dykstra, LA; McNutt, R; Schoenbaum, GM; Yarbrough, J | 1 |
| Mokhtari, M; Tafani, JA; Zajac, JM | 1 |
| Bodnar, RJ; Kiefel, JM; Rossi, GC | 1 |
| Goldberg, SR; Heidbreder, C; Shippenberg, TS | 1 |
| Durham, RA; Lookingland, KJ; Manzanares, J; Moore, KE | 1 |
| Iwamoto, Y; Kamei, J; Kasuya, Y; Misawa, M; Nagase, H; Suzuki, T | 3 |
| Bowen, WD; Holtzman, SG; Jones, DN; Portoghese, PS | 1 |
| D'Alecy, LG; Mayfield, KP | 1 |
| Búzás, B; Cox, BM; Izenwasser, S; Portoghese, PS | 1 |
| Freye, E; Latasch, L | 2 |
| Dewey, WL; Dombrowski, DS; Smith, FL; Welch, SP | 1 |
| Hitosugi, H; Kamei, J; Kasuya, Y; Kawashima, N; Misawa, M; Nagase, H | 1 |
| Olmsted, SL; Portoghese, PS; Takemori, AE | 1 |
| Acquas, E; Di Chiara, G; Meloni, M | 1 |
| Cheng, PY; Decena, J; McCabe, S; Soong, Y; Szeto, HH; Wu, D | 1 |
| Lanthorn, TH; Watson, GB | 1 |
| Bilsky, EJ; Glaccum, MB; Hubbell, CL; Porreca, F; Portoghese, PS; Reid, LD | 1 |
| Akami, T; Akioka, K; Arakawa, K; Nagase, H; Nakai, I; Oka, T; Okamoto, M | 1 |
| Kameyama, T; Mori, E; Ukai, M | 1 |
| Contreras, PC; Dorn, CR; Drower, EJ; Markos, CS; Rafferty, MF; Unnerstall, JR | 1 |
| Ho, IK; Hoskins, B; Jaw, SP | 2 |
| Bodnar, RJ; Koch, JE | 1 |
| Contreras, PC; Drower, E; Rafferty, MF; Tam, L | 1 |
| Collins, KA; Portoghese, PS; Tseng, LF | 1 |
| Kawabata, A; Takagi, H; Umeda, N | 1 |
| Bourgoin, S; Cesselin, F; Collin, E; Frechilla, D; Hamon, M; Le Bars, D; Pohl, M | 1 |
| Henriksen, SJ; Koob, GF; Mattox, A; Negus, SS; Pasternak, GW; Portoghese, PS; Takemori, AE; Weinger, MB | 1 |
| Tiseo, PJ; Yaksh, TL | 1 |
| Desmeules, JA; Gacel, G; Guilbaud, G; Kayser, V; Roques, BP | 1 |
| Andres-Trelles, F; Baamonde, A; Hidalgo, A; Menendez, L | 1 |
| Desmeules, JA; Guilbaud, G; Kayser, V | 1 |
| Kitchen, I; Muhammad, BY | 1 |
| Cheng, PY; Decena, JA; McCabe, S; Soong, Y; Szeto, HH; Wu, D | 1 |
| Adams, JU; Adler, MW; Geller, EB; Tallarida, RJ | 1 |
| Beczkowska, IW; Bodnar, RJ; Bostock, ME; Koch, JE; Leibowitz, SF | 1 |
| Magyar, A; Medzihradszky, K; Rónai, AZ | 1 |
| Aramaki, T; Inoki, R; Maeda, S; Ohnishi, T; Ooi, Y; Saito, K; Shinno, E | 1 |
| Babovic-Vuksanovic, D; de Vries, TJ; Elmer, G; Shippenberg, TS | 1 |
| Coderre, TJ; Fundytus, ME; Schiller, PW; Shapiro, M; Weltrowska, G | 1 |
| Hansson, P; Lundeberg, T; Yu, LC | 1 |
| Bhargava, HN; House, RV; Kozak, JT; Thomas, PT | 1 |
| Adler, MW; Chen, XH; Geller, EB | 1 |
| Cowan, A; Hunter, JC; Kovelowski, CJ; Lai, J; Malan, TP; Ossipov, MH; Porreca, F; Wheeler-Aceto, H | 1 |
| Kinter, CM; Lever, JR; Scheffel, U; Stathis, M | 1 |
| Borgbjerg, FM; Frigast, C; Madsen, JB | 1 |
| Negri, L; Noviello, L; Noviello, V | 1 |
| Iwatsubo, K; Kawabata, A; Takagi, H; Takaya, S | 1 |
| Karasawa, F; Kitani, Y; Kuribara, H; Morita, T; Sato, T; Uchihashi, Y | 1 |
| Funada, M; Schutz, CG; Shippenberg, TS | 1 |
| Knapp, RJ; Li, X; Malatynska, E; Roeske, WR; Stropova, D; Varga, EV; Yamamura, HI; Zalewska, T | 1 |
| Heagy, W; Shahabi, NA; Sharp, BM | 1 |
| Potter, DE; Wang, D | 1 |
| Anacardio, R; Attila, M; Bryant, SD; Capasso, A; Guerrini, R; Lazarus, LH; Salvadori, S; Sorrentino, L | 1 |
| Amendola, CA; Fishkin, MD; Hubbell, CL; Reid, LD; Tsai, J | 1 |
| Honkanen, A; Hyytiä, P; Korpi, ER; Sarviharju, M; Vilamo, L; Wegelius, K | 1 |
| Calderon, S; Hruby, VJ; Knapp, RJ; Malatynska, E; Rice, K; Roeske, WR; Waite, S; Wang, Y; Yamamura, HI | 1 |
| Gouardères, C; Jhamandas, K; Sutak, M; Zajac, JM | 1 |
| Feng, YZ; Ho, IK; Rockhold, RW; Tokuyama, S; Zhang, T; Zhu, H | 1 |
| Heidbreder, C; Shippenberg, TS; Shoaib, M | 1 |
| Spanagel, R | 1 |
| Casares, F; Liu, U; Stefano, GB | 1 |
| Cook, CD; Morgan, D; Negus, SS; Picker, MJ | 1 |
| Gao, P | 1 |
| Ahtee, L; Piepponen, TP | 1 |
| Bian, D; Malan, TP; Nichols, ML; Ossipov, MH; Porreca, F | 1 |
| Goldstein, BD; Zachariou, V | 1 |
| Holtzman, SG; Justice, JB; Schad, CA | 1 |
| Feuerstein, TJ; Gleichauf, O; Jackisch, R; Landwehrmeyer, GB; Peckys, D; Scheremet, R | 1 |
| Akil, H; Ardati, A; Civelli, O; Hoversten, MT; Meng, F; Monsma, FJ; Reinscheid, RK; Taylor, LP; Ueda, Y; Watson, SJ | 1 |
| Catheline, G; Guilbaud, G; Kayser, V | 1 |
| Krylatov, AV; Lishmanov, IuB; Maslov, LN; Uskina, EV | 1 |
| Bodnar, RJ; Leventhal, L | 1 |
| Fuentes, JA; Reche, I; Ruiz-Gayo, M | 1 |
| Gent, JP; Goodchild, CS; Guo, Z; Musgreave, A | 1 |
| Cai, YC; Cheng, ZJ; Fan, GH; Jiang, LZ; Ma, L; Pei, G | 1 |
| Dannals, RF; Frost, JJ; Kinter, CM; Lever, JR; Madar, I; Mathews, WB; Musachio, JL; Ravert, HT; Scheffel, U | 1 |
| Laorden, ML; Llobel, F | 1 |
| Schulz, R; Wehmeyer, A | 1 |
| Breivogel, CS; Childers, SR; Selley, DE | 2 |
| Balboni, G; Bryant, SD; Guerrini, R; Lazarus, LH; Salvadori, S; Tomatis, R | 1 |
| Barg, J; Eilam, Y; Ela, C; Hasin, Y; Vogel, Z | 1 |
| Aarnisalo, AA; Idänpään-Heikkilä, JJ; Kalso, E; Kontinen, VK; Panula, P | 1 |
| Burkey, TH; Hosohata, K; Hosohata, Y; Hruby, VJ; Knapp, RJ; Nagase, H; Porreca, F; Quock, RM; Rice, KC; Roeske, WR; Yamamura, HI; Zhang, X | 1 |
| Gingras, J; Hepburn, MJ; Kuhn, CM; Little, PJ | 1 |
| Dawson-Basoa, M; Gintzler, AR | 1 |
| Hernández, LL; Watson, KL | 1 |
| Bartosz-Bechowski, H; Davis, P; Hruby, VJ; Kramer, TH; Porreca, F | 1 |
| Coulais, Y; Francés, B; Goeldner, M; Guiraud, R; Hirth, C; Méjean-Galzi, A; Tafani, JA; Zajac, JM | 1 |
| Ahtee, L; Katajamäki, J; Kivastik, T; Piepponen, TP; Zharkovsky, A | 1 |
| Gross, GJ; Hsu, AK; Schultz, JJ | 1 |
| Abbruscato, TJ; Davis, TP; Hruby, VJ; Thomas, SA | 1 |
| Capobianchi, MR; Negri, L; Noviello, L; Papadia, S | 1 |
| Chapman, I; Hope, PJ; Horowitz, M; Morley, JE; Wittert, GA | 1 |
| Giuliani, S; Maggi, CA | 1 |
| Gordon, FJ; Holtzman, SG; Patterson, AB | 1 |
| Burke, TF; Garner, HR; Lawhorn, CD; Stoner, JM; Wessinger, WD | 1 |
| Bertolucci, M; De Simoni, MG; Perego, C | 1 |
| Fekete, MI; Gergely, P; Murányi, A; Nagy, GM | 1 |
| Childers, SR; Sim, LJ | 1 |
| Artico, M; Clarke, GD; Dondio, G; Eggleston, DS; Farina, C; Petrillo, P; Petrone, G; Ronzoni, S; Vecchietti, V; Visentin, L | 1 |
| Lysle, DT; Perez, L | 1 |
| Braida, D; Gori, E; Paladini, E; Sala, M | 1 |
| Higashiyama, K; Kamei, J; Kubo, H; Li, J; Nagase, H; Ohmiya, S; Ohsawa, M; Takahashi, H; Xiao, P | 1 |
| Blake, AD; Bot, G; Li, S; Reisine, T | 1 |
| Józefowski, S; Płytycz, B | 1 |
| Cozzolino, A; Di Chiara, G; Giagheddu, M; Marrosu, F; Puligheddu, M | 1 |
| Adams, DJ; Trequattrini, C | 1 |
| He, Z; Ho, IK; Tsang, BK; Wongchanapai, W | 1 |
| Aasmundstad, TA; Alkana, RL; Grung, M; Handal, M; Mørland, J; Skurtveit, S | 1 |
| Honkanen, A; Hyytiä, P; Korpi, ER; Ovaska, T; Soini, SL | 1 |
| Hao, JX; Xu, XJ; Yu, W | 1 |
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| Abul-Husn, NS; Jhamandas, K; Milne, B; Sutak, M | 1 |
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3 review(s) available for naltrexone and naltrindole
| Article | Year |
|---|---|
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic | 2000 |
The design of delta-selective opioid receptor antagonists.
Topics: Amino Acid Sequence; Animals; Drug Design; Humans; Molecular Conformation; Molecular Sequence Data; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta | 1993 |
Kappa receptor bivalent ligands.
Topics: Dimerization; Ligands; Naltrexone; Narcotic Antagonists; Receptors, Opioid, kappa; Structure-Activity Relationship | 2007 |
738 other study(ies) available for naltrexone and naltrindole
| Article | Year |
|---|---|
O3-(2-carbomethoxyallyl) ethers of opioid ligands derived from oxymorphone, naltrexone, etorphine, diprenorphine, norbinaltorphimine, and naltrindole. Unexpected O3-dealkylation in the opioid radioligand displacement assay.
Topics: Alkylation; Animals; Brain; Diprenorphine; Drug Stability; Ethers; Etorphine; Guinea Pigs; Indoles; Methacrylates; Molecular Structure; Morphinans; Naltrexone; Narcotic Antagonists; Narcotics; Oxymorphone; Phenols; Radioligand Assay; Receptors, Opioid; Tritium | 1992 |
An approach to the design of receptor-type-selective non-peptide antagonists of peptidergic receptors: delta opioid antagonists.
Topics: Amino Acid Sequence; Drug Design; Enkephalins; Indoles; Molecular Sequence Data; Morphinans; Naltrexone; Protein Conformation; Receptors, Opioid; Receptors, Opioid, delta; Structure-Activity Relationship | 1991 |
Role of spacer and address components in peptidomimetic delta opioid receptor antagonists related to naltrindole.
Topics: Animals; Chemical Phenomena; Chemistry; Guinea Pigs; Indoles; Male; Mice; Morphinans; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Structure-Activity Relationship | 1991 |
Design of peptidomimetic delta opioid receptor antagonists using the message-address concept.
Topics: Animals; Computer Simulation; Drug Design; Guinea Pigs; In Vitro Techniques; Indoles; Mice; Morphinans; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Structure-Activity Relationship | 1990 |
Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors.
Topics: Analgesics; Animals; Binding Sites; Cell Line; CHO Cells; Cloning, Molecular; Cricetinae; Ligands; PC12 Cells; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Software | 1994 |
Cloning and functional comparison of kappa and delta opioid receptors from mouse brain.
Topics: Amino Acid Sequence; Animals; Base Sequence; Brain Chemistry; Cloning, Molecular; In Situ Hybridization; Mice; Molecular Sequence Data; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Somatostatin; RNA, Messenger; Sequence Homology, Amino Acid; Substrate Specificity; Tissue Distribution | 1993 |
Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications.
Topics: Animals; Aorta, Thoracic; Cocaine; Cyclic AMP; Electric Stimulation; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Mice; Muscle, Smooth; Opioid-Related Disorders; Rats; Receptors, Dopamine; Receptors, Opioid; Receptors, Serotonin; Substance-Related Disorders | 1998 |
Synthesis, opioid receptor binding, and biological activities of naltrexone-derived pyrido- and pyrimidomorphinans.
Topics: Analgesics; Animals; Binding, Competitive; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Ileum; Male; Mice; Mice, Inbred Strains; Morphinans; Morphine; Muscle Contraction; Naltrexone; Protein Binding; Rats; Receptors, Opioid; Vas Deferens | 1999 |
Investigation of the selectivity of oxymorphone- and naltrexone-derived ligands via site-directed mutagenesis of opioid receptors: exploring the "address" recognition locus.
Topics: Amino Acid Sequence; Base Sequence; Binding, Competitive; Cell Line; Humans; Ligands; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Naltrexone; Narcotic Antagonists; Oxymorphone; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2001 |
14-amino, 14-alkylamino, and 14-acylamino analogs of oxymorphindole. Differential effects on opioid receptor binding and functional profiles.
Topics: Analgesics, Opioid; Animals; Binding, Competitive; CHO Cells; Cricetinae; Morpholines; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, mu; Structure-Activity Relationship | 2003 |
Opioid binding and in vitro profiles of a series of 4-hdroxy-3-methoxyindolomorphinans. Transformation of a delta-selective ligand into a high affinity kappa-selective ligand by introduction of a 5,14-substituted bridge.
Topics: Animals; Bridged-Ring Compounds; CHO Cells; Cricetinae; Indoles; Ligands; Morphinans; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2003 |
Identification of opioid ligands possessing mixed micro agonist/delta antagonist activity among pyridomorphinans derived from naloxone, oxymorphone, and hydromorphone [correction of hydropmorphone].
Topics: Analgesics; Animals; Binding Sites; Brain; Drug Tolerance; Electric Stimulation; Guinea Pigs; Hydromorphone; Ileum; In Vitro Techniques; Ligands; Male; Mice; Mice, Inbred ICR; Morphinans; Muscle Contraction; Muscle, Smooth; Naloxone; Oxymorphone; Pyridines; Radioligand Assay; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Vas Deferens | 2004 |
Identification of a new scaffold for opioid receptor antagonism based on the 2-amino-1,1-dimethyl-7-hydroxytetralin pharmacophore.
Topics: Binding Sites; Models, Molecular; Narcotic Antagonists; Piperidines; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship; Tetrahydronaphthalenes | 2004 |
Effects of substitution on the pyrrole N atom in derivatives of tetrahydronaltrindole, tetrahydrooxymorphindole, and a related 4,5-epoxyphenylpyrrolomorphinan.
Topics: Analgesics; Animals; Binding, Competitive; CHO Cells; Cricetinae; Cricetulus; Humans; Indoles; Ligands; Morphinans; Naltrexone; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship | 2004 |
Highly potent and selective phenylmorphan-based inverse agonists of the opioid delta receptor.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; CHO Cells; Cricetinae; Cricetulus; Humans; Radioligand Assay; Receptors, Opioid, delta; Stereoisomerism; Structure-Activity Relationship | 2006 |
Naloxone acts as a potent analgesic in transgenic mouse models of sickle cell anemia.
Topics: Analgesics; Analgesics, Opioid; Anemia, Sickle Cell; Animals; Chemokine CCL5; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Drug Synergism; Injections, Intraventricular; Injections, Spinal; Injections, Subcutaneous; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Knockout; Mice, Transgenic; Morphine; Naloxone; Pain; Pain Measurement; Receptors, CCR5 | 2007 |
14-O-Heterocyclic-substituted naltrexone derivatives as non-peptide mu opioid receptor selective antagonists: design, synthesis, and biological studies.
Topics: Binding, Competitive; Chemistry, Pharmaceutical; Drug Design; Humans; Kinetics; Ligands; Molecular Conformation; Molecular Structure; Naltrexone; Narcotic Antagonists; Nitrogen; Peptides; Protein Structure, Tertiary; Receptors, Opioid, mu | 2009 |
Syntheses of novel high affinity ligands for opioid receptors.
Topics: Analgesics, Opioid; Crystallography, X-Ray; Furans; Humans; Ligands; Naltrexone; Narcotic Antagonists; Protein Binding; Receptors, Opioid | 2009 |
Synthesis and pharmacological evaluation of 6-naltrexamine analogs for alcohol cessation.
Topics: Alcohol Deterrents; Alcoholism; Animals; Humans; Liver; Male; Mice; Naltrexone; Nociceptin Receptor; Protein Binding; Rats; Rats, Wistar; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship | 2009 |
Generation of novel radiolabeled opiates through site-selective iodination.
Topics: Animals; Binding Sites; Binding, Competitive; CHO Cells; Cricetinae; Cricetulus; Humans; Iodine Radioisotopes; Molecular Structure; Neurotransmitter Agents; Oxymorphone; Radioligand Assay; Receptors, Opioid | 2011 |
Opioid δ₁ receptor antagonist 7-benzylidenenaltrexone as an effective resistance reverser for chloroquine-resistant Plasmodium chabaudi.
Topics: Antimalarials; Benzylidene Compounds; Chloroquine; Drug Resistance; Molecular Structure; Naltrexone; Parasitic Sensitivity Tests; Plasmodium chabaudi; Receptors, Opioid, mu; Stereoisomerism; Structure-Activity Relationship | 2011 |
Opioid receptor selectivity profile change via isosterism for 14-O-substituted naltrexone derivatives.
Topics: Molecular Conformation; Naltrexone; Narcotic Antagonists; Stereoisomerism; Structure-Activity Relationship | 2013 |
Binding mode characterization of 6α- and 6β-N-heterocyclic substituted naltrexamine derivatives via docking in opioid receptor crystal structures and site-directed mutagenesis studies: application of the 'message-address' concept in development of mu opio
Topics: Amino Acid Sequence; Animals; Binding Sites; Cattle; Humans; Molecular Docking Simulation; Molecular Sequence Data; Mutagenesis, Site-Directed; Naltrexone; Protein Binding; Protein Structure, Tertiary; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Proteins; Sequence Alignment | 2013 |
Pyrrolo- and pyridomorphinans: non-selective opioid antagonists and delta opioid agonists/mu opioid partial agonists.
Topics: Analgesics, Opioid; Animals; CHO Cells; Cricetinae; Cricetulus; Humans; Kinetics; Morphinans; Protein Binding; Pyridines; Pyrroles; Receptors, Opioid, delta; Receptors, Opioid, mu; Structure-Activity Relationship | 2014 |
Antitrichomonal activity of δ opioid receptor antagonists, 7-benzylidenenaltrexone derivatives.
Topics: Animals; Antitrichomonal Agents; Benzylidene Compounds; CHO Cells; Cricetulus; Dose-Response Relationship, Drug; Molecular Structure; Naltrexone; Receptors, Opioid, delta; Structure-Activity Relationship; Trichomonas vaginalis | 2017 |
Involvement of opioid mechanisms in peripheral motor control of detrusor muscle.
Topics: Animals; Electric Stimulation; Enkephalins; Ganglionic Blockers; Hexamethonium; Hexamethonium Compounds; Humans; Indoles; Male; Morphinans; Morphine; Muscle Contraction; Muscles; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Substance P; Sympatholytics | 1992 |
Characterization of [3H]naltrindole binding to delta opioid receptors in rat brain.
Topics: Animals; Binding, Competitive; Brain; Indoles; Male; Membranes; Morphinans; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta | 1992 |
The immunosuppressive effect of delta-opioid receptor antagonist on rat renal allograft survival.
Topics: Animals; Graft Survival; Immunosuppressive Agents; Indoles; Kidney Transplantation; Male; Morphinans; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Transplantation, Homologous | 1992 |
Immunosuppressive effect of delta-opioid receptor antagonist on xenogeneic mixed lymphocyte reaction.
Topics: Analgesics; beta-Endorphin; Cell Survival; Cells, Cultured; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Humans; Immunosuppressive Agents; Indoles; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Lymphocytes; Morphinans; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta | 1992 |
Agonist and antagonist activities of ligands derived from naltrexone and oxymorphone.
Topics: Animals; Indoles; Ligands; Male; Mice; Morphinans; Morpholines; Naltrexone; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa | 1992 |
Kappa-opioid receptor stimulation abolishes mu- but not delta-mediated inhibitory control of spinal Met-enkephalin release.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Indoles; Injections, Spinal; Male; Morphinans; Naloxone; Naltrexone; Neurons; Oligopeptides; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1992 |
Hypothermic effect of D-Ala-deltorphin II, a selective delta opioid receptor agonist.
Topics: Animals; Body Temperature; Indoles; Injections, Intraventricular; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta | 1992 |
Naloxone-induced analgesia in diabetic mice.
Topics: Analgesia; Animals; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Drug Interactions; Indoles; Injections, Subcutaneous; Male; Mice; Mice, Inbred ICR; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid | 1992 |
Modulation of kappa-mediated antitussive activity in rats by a delta-agonist.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Antitussive Agents; Cough; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Indoles; Male; Morphinans; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Reflex | 1992 |
Delta opiate receptors mediate tail-shock induced antinociception at supraspinal levels.
Topics: Analysis of Variance; Animals; Cerebral Ventricles; Dose-Response Relationship, Drug; Electroshock; Indoles; Injections, Intraventricular; Injections, Spinal; Male; Morphinans; Naltrexone; Narcotic Antagonists; Pain; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Spinal Cord | 1992 |
Interaction between opioid antagonists and amphetamine: evidence for mediation by central delta opioid receptors.
Topics: Amphetamine; Analgesia; Animals; Brain; Indoles; Male; Morphinans; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta | 1992 |
Antinociception after intracerebroventricular administration of naltrindole in the mouse.
Topics: Animals; Dose-Response Relationship, Drug; Indoles; Injections, Intraventricular; Male; Mice; Morphinans; Naltrexone; Narcotic Antagonists; Nociceptors; Receptors, Opioid; Receptors, Opioid, delta | 1992 |
Spinal antinociception by Tyr-D-Ser(otbu)-Gly-Phe-Leu-Thr, a selective delta-opioid receptor agonist.
Topics: Amino Acid Sequence; Analgesics; Animals; Dose-Response Relationship, Drug; Indoles; Injections, Spinal; Male; Molecular Sequence Data; Morphinans; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta | 1992 |
Central opioid modulation of breathing dynamics in the fetal lamb: effects of [D-Pen2,D-Pen5]-enkephalin and partial antagonism by naltrindole.
Topics: Analgesics; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fetus; Indoles; Morphinans; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, mu; Respiration; Sheep | 1992 |
Evidence that endogenous opioids mediate the antinociceptive effects of intrathecally administered calcium in mice.
Topics: Analgesia; Animals; Calcium; Drug Interactions; Endorphins; Indoles; Injections, Spinal; Male; Mice; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid | 1992 |
Opioid receptor antagonists discriminate between presynaptic mu and delta receptors and the adenylate cyclase-coupled opioid receptor complex in the brain.
Topics: Acetylcholine; Adenylyl Cyclases; Animals; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Indoles; Male; Morphinans; Naltrexone; Narcotic Antagonists; Norepinephrine; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu | 1992 |
Isobolographic and dose-response analyses of the interaction between intrathecal mu and delta agonists: effects of naltrindole and its benzofuran analog (NTB).
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Indoles; Injections, Spinal; Male; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu | 1992 |
Effects of the delta-opioid receptor antagonist naltrindole on antinociceptive responses to selective delta-agonists in post-weanling rats.
Topics: Analgesics; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Indoles; Male; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain Measurement; Rats; Rats, Wistar; Receptors, Opioid, delta | 1992 |
The delta receptor is involved in sufentanil-induced respiratory depression--opioid subreceptors mediate different effects.
Topics: Animals; Carbon Dioxide; Dogs; Dose-Response Relationship, Drug; Evoked Potentials, Somatosensory; Indoles; Morphinans; Naltrexone; Narcotic Antagonists; Neurons, Afferent; Nociceptors; Oxygen; Receptors, Opioid; Receptors, Opioid, delta; Respiration; Sufentanil | 1992 |
Opioid agonist and antagonist activities of morphindoles related to naltrindole.
Topics: Analgesia; Animals; Guinea Pigs; Indoles; Male; Mice; Morphinans; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Structure-Activity Relationship | 1992 |
Effects of naltrindole and nor-binaltorphimine treatment on antinociception induced by sub-acute selective mu opioid receptor blockade.
Topics: Animals; Indoles; Male; Morphinans; Naltrexone; Pain; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sensitivity and Specificity | 1992 |
Kappa opiate receptors mediate tail-shock induced antinociception at spinal levels.
Topics: Analysis of Variance; Animals; Dose-Response Relationship, Drug; Electroshock; Indoles; Injections, Spinal; Male; Morphinans; Naltrexone; Narcotic Antagonists; Pain; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Somatostatin; Spinal Cord | 1992 |
Combination of a delta opioid receptor agonist but not a mu opioid receptor agonist with the D1-selective dopamine receptor agonist SKF 38393 markedly potentiates different behaviors in mice.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Analysis of Variance; Animals; Behavior, Animal; Benzazepines; Dopamine Agents; Dopamine Antagonists; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Grooming; Indoles; Injections, Intraventricular; Male; Mice; Morphinans; Motor Activity; Naltrexone; Sulpiride | 1992 |
Endogenous opioids may be involved in idazoxan-induced food intake.
Topics: Adrenergic alpha-Antagonists; Animals; Dioxanes; Dose-Response Relationship, Drug; Eating; Endorphins; Idazoxan; Indoles; Male; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains | 1992 |
Mu opioid receptors are associated with the induction of hippocampal mossy fiber long-term potentiation.
Topics: Animals; Evoked Potentials; Hippocampus; Indoles; Male; Morphinans; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Somatostatin; Synapses; Time Factors | 1992 |
Effect of mu-, kappa-, and delta-selective opioid agonists on thermoregulation in the rat.
Topics: Amino Acid Sequence; Animals; Body Temperature; Body Temperature Regulation; Brain; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Indoles; Injections, Intraventricular; Male; Molecular Sequence Data; Morphinans; Naltrexone; Narcotic Antagonists; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1992 |
Identification of a novel receptor mediating substance P-induced behavior in the mouse.
Topics: Analysis of Variance; Animals; Behavior, Animal; Binding Sites; Indoles; Injections, Spinal; Male; Mice; Morphinans; Naloxone; Naltrexone; Peptide Fragments; Substance P | 1992 |
Cocaine place preference is blocked by the delta-opioid receptor antagonist, naltrindole.
Topics: Animals; Cocaine; Conditioning, Operant; Indoles; Male; Morphinans; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Lew | 1992 |
L-leucyl-L-arginine, naltrindole and D-arginine block antinociception elicited by L-arginine in mice with carrageenin-induced hyperalgesia.
Topics: Analgesics; Animals; Arginine; Brain; Carrageenan; Dipeptides; Endorphins; Hyperalgesia; Indoles; Injections, Subcutaneous; Male; Mice; Morphinans; Naltrexone; Narcotic Antagonists; Pain Measurement; Stereoisomerism | 1992 |
Repeated systemic administration of the mixed inhibitor of enkephalin-degrading enzymes, RB101, does not induce either antinociceptive tolerance or cross-tolerance with morphine.
Topics: Analgesics; Animals; Disulfides; Dose-Response Relationship, Drug; Drug Tolerance; Indoles; Male; Mice; Morphinans; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Phenylalanine; Prodrugs; Reaction Time | 1992 |
Naltrindole retards tolerance development to morphine-induced effects on EEG and EEG power spectra.
Topics: Animals; Brain; Drug Tolerance; Electroencephalography; Female; Indoles; Injections, Intraventricular; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains | 1992 |
Feedback inhibition of met-enkephalin release from the rat spinal cord in vivo.
Topics: Animals; Calcitonin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Feedback; Indoles; Injections, Spinal; Leucine; Male; Morphinans; Naloxone; Naltrexone; Oligopeptides; Radioimmunoassay; Rats; Rats, Inbred Strains; Spinal Cord; Thiorphan | 1992 |
Opioid modulation of immunoglobulin production by lymphocytes isolated from Peyer's patches and spleen.
Topics: Animals; Antibody Formation; Cells, Cultured; Concanavalin A; In Vitro Techniques; Indoles; Lipopolysaccharides; Lymphocytes; Morphinans; Morpholines; Naltrexone; Peyer's Patches; Spleen | 1992 |
Pentazocine-induced biphasic analgesia in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics; Animals; Drug Administration Schedule; Drug Interactions; Drug Tolerance; Indoles; Injections, Intraventricular; Male; Mice; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Pentazocine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Time Factors | 1991 |
(D-Ala2)deltorphin II: D1-dependent stereotypies and stimulation of dopamine release in the nucleus accumbens.
Topics: Animals; Brain; Caudate Nucleus; Cerebral Ventricles; Dopamine; Endorphins; Functional Laterality; Indoles; Infusions, Parenteral; Injections, Intraventricular; Male; Morphinans; Motor Activity; Naloxone; Naltrexone; Nucleus Accumbens; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Stereotyped Behavior | 1991 |
Differential effects of selective mu-, kappa- and delta-opioid antagonists on electroshock seizure threshold in mice.
Topics: Animals; Anticonvulsants; Bicuculline; Dose-Response Relationship, Drug; Electroshock; gamma-Aminobutyric Acid; Indoles; Male; Mice; Mice, Inbred Strains; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Phenytoin; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1991 |
Opioid delta agonists and endogenous enkephalins induce different emotional reactivity than mu agonists after injection in the rat ventral tegmental area.
Topics: Animals; Anxiety; Emotions; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Exploratory Behavior; Indoles; Injections; Male; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Tegmentum Mesencephali | 1991 |
Selective blockage of delta opioid receptors prevents the development of morphine tolerance and dependence in mice.
Topics: Animals; Drug Implants; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Indoles; Isothiocyanates; Male; Mice; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Nociceptors; Receptors, Opioid; Receptors, Opioid, delta; Substance-Related Disorders; Thiocyanates | 1991 |
The opioid activity and receptor selectivity of fluorinated Leu5 enkephalin analogues in vitro and in vivo.
Topics: Analgesics; Animals; Enkephalin, Leucine; Guinea Pigs; Ileum; In Vitro Techniques; Indoles; Male; Mice; Mice, Inbred Strains; Morphinans; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid | 1991 |
Selective antagonism by naltrindole of the antinociceptive effects of the delta opioid agonist cyclic[D-penicillamine2-D-penicillamine5]enkephalin in the rat.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Indoles; Injections, Spinal; Injections, Subcutaneous; Male; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Nociceptors; Pain Measurement; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord | 1991 |
Modulation of mu-mediated antitussive activity in rats by a delta agonist.
Topics: Aerosols; Animals; Antitussive Agents; Capsaicin; Cisterna Magna; Cough; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Indoles; Injections; Male; Morphinans; Morphine; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1991 |
Behavioural effects of deltorphins in rats.
Topics: Analgesics; Animals; Behavior, Animal; Indoles; Injections, Intraventricular; Male; Morphinans; Motor Activity; Naloxone; Naltrexone; Oligopeptides; Pain Measurement; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Social Behavior; Stereotyped Behavior | 1991 |
Involvement of spinal kappa opioid receptors in the antagonistic effect of dynorphins on morphine antinociception.
Topics: Animals; Dynorphins; Indoles; Male; Mice; Morphinans; Morphine; Naltrexone; Pain; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Spine; Stereoisomerism | 1991 |
Investigation of the different types of opioid receptor involved in electroconvulsive shock-induced antinociception and catalepsy in the rat.
Topics: Analgesia; Animals; Catalepsy; Electroshock; Indoles; Injections, Intraperitoneal; Male; Morphinans; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid | 1991 |
In vivo tonic inhibition of spinal substance P (-like material) release by endogenous opioid(s) acting at delta receptors.
Topics: Amino Acid Sequence; Animals; Depression, Chemical; Indoles; Injections, Spinal; Male; Molecular Sequence Data; Morphinans; Naloxone; Naltrexone; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Secretory Rate; Spinal Cord; Substance P | 1991 |
Distribution and analgesia of [3H][D-Pen2, D-Pen5]enkephalin and two halogenated analogs after intravenous administration.
Topics: Analgesics; Animals; Binding, Competitive; Drug Stability; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Indoles; Injections, Intravenous; Male; Mice; Mice, Inbred Strains; Morphinans; Naloxone; Naltrexone; Neprilysin; Tissue Distribution; Tritium | 1991 |
Antinociceptive and gastrointestinal transit effects of cholecystokinin (CCK-8) and related analogs of CCK-8 in the mouse.
Topics: Amino Acid Sequence; Analgesics; Animals; Benzodiazepinones; Cholecystokinin; Devazepide; Gastric Emptying; Gastrointestinal Transit; Indoles; Male; Mice; Mice, Inbred ICR; Molecular Sequence Data; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Peptide Fragments; Peptides; Phenylurea Compounds; Reaction Time; Receptors, Cholecystokinin; Sincalide | 1991 |
Effects of selective opiate antagonists on morphine-induced hyperalgesia in domestic fowl.
Topics: Analgesia; Animals; Chickens; Dose-Response Relationship, Drug; Hot Temperature; Indoles; Injections, Intraventricular; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Respiration | 1991 |
Differential antagonism of delta opioid agonists by naltrindole and its benzofuran analog (NTB) in mice: evidence for delta opioid receptor subtypes.
Topics: Analgesia; Animals; Indoles; Male; Mice; Morphinans; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta | 1991 |
Systemic administration of (Tyr-D-Ser(O-tert-butyl)-Gly-Phe-Leu-Thr(O-tert-butyl), a highly selective delta opioid agonist, induces mu receptor-mediated analgesia in mice.
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Indoles; Injections, Intravenous; Male; Mice; Morphinans; Naltrexone; Narcotic Antagonists; Oligopeptides; Receptors, Opioid; Receptors, Opioid, mu | 1991 |
Characterisation of opioid binding sites using selective antagonists.
Topics: Animals; Binding, Competitive; Brain; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; In Vitro Techniques; Indoles; Morphinans; Naltrexone; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Somatostatin | 1990 |
The selectivity of the opioid antagonist, naltrindole, for delta-opioid receptors.
Topics: Animals; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guanylyl Imidodiphosphate; Guinea Pigs; In Vitro Techniques; Indoles; Male; Mice; Mice, Inbred Strains; Morphinans; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sodium; Vas Deferens | 1990 |
Delta opioid antagonist, naltrindole, selectively blocks analgesia induced by DPDPE but not DAGO or morphine.
Topics: Analgesia; Analgesics; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Indoles; Injections, Intraventricular; Male; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Reaction Time; Restraint, Physical; Stress, Psychological | 1991 |
Conformational search in enkephalin analogues containing a disulfide bond.
Topics: Amino Acid Sequence; Disulfides; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Indoles; Models, Molecular; Molecular Sequence Data; Morphinans; Naltrexone; Protein Conformation; Thermodynamics | 1990 |
Supraspinal analgesic action of pentazocine in mice.
Topics: Analgesics; Animals; Drug Tolerance; Indoles; Injections, Intraventricular; Male; Mice; Morphinans; Naltrexone; Pain Measurement; Pentazocine; Receptors, Opioid; Time Factors | 1990 |
Effects of chronic treatment with specific antagonists on analgesia and physical dependence on morphine in rats.
Topics: Analgesics; Animals; Indoles; Male; Morphinans; Morphine Dependence; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Weight Loss | 1990 |
Apparent affinity of opioid antagonists in morphine-treated rhesus monkeys discriminating between saline and naltrexone.
Topics: Animals; Discrimination Learning; Dose-Response Relationship, Drug; Female; Indoles; Macaca mulatta; Morphinans; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, mu | 1990 |
A lack of potency for the delta-opioid antagonist naltrindole after microinjection into the rostral ventrolateral medulla of rabbits.
Topics: Animals; Blood Pressure; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Indoles; Male; Medulla Oblongata; Microinjections; Morphinans; Naltrexone; Narcotic Antagonists; Rabbits; Receptors, Opioid; Receptors, Opioid, delta | 1990 |
"Paradoxical" analgesia and aggravated morphine dependence induced by opioid antagonists.
Topics: Animals; Body Weight; Indoles; Male; Morphinans; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome; Substance-Related Disorders | 1990 |
Antagonism of swim-stress-induced antinociception by the delta-opioid receptor antagonist naltrindole in adult and young rats.
Topics: Aging; Animals; Animals, Newborn; Corticosterone; Indoles; Male; Morphinans; Naltrexone; Narcotic Antagonists; Nociceptors; Physical Exertion; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Stress, Psychological | 1990 |
Further evidence for the implication of a kappa-opioid receptor mechanism in the production of psychological stress-induced analgesia.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics; Animals; Benzomorphans; Drug Tolerance; Electroshock; Indoles; Male; Mice; Mice, Inbred Strains; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Stress, Psychological; Swimming | 1990 |
Differential effect of opioids on immunoglobulin production by lymphocytes isolated from Peyer's patches and spleen.
Topics: Adrenocorticotropic Hormone; Animals; Cells, Cultured; Concanavalin A; Endorphins; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Immunoglobulins; Indoles; Lymphocytes; Male; Mice; Mice, Inbred C57BL; Morphinans; Naltrexone; Narcotic Antagonists; Peyer's Patches; Receptors, Interleukin-2; Spleen; T-Lymphocytes | 1990 |
In vivo and in vitro investigation of naltrindole, a delta-opioid antagonist.
Topics: Animals; Dose-Response Relationship, Drug; Electric Stimulation; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Indoles; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphinans; Morphine; Muscle Contraction; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Reaction Time; Receptors, Opioid; Receptors, Opioid, delta; Vas Deferens | 1990 |
Exploring delta-receptor function using the selective opioid antagonist naltrindole.
Topics: Animals; Behavior, Animal; Indoles; Male; Morphinans; Naltrexone; Narcotic Antagonists; Pain; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Stress, Psychological | 1989 |
Delta opioid receptor selective alkaloid agonists and antagonists.
Topics: Animals; Binding, Competitive; Guinea Pigs; Indoles; Mice; Morphinans; Naltrexone; Narcotic Antagonists; Narcotics; Nociceptors; Receptors, Opioid; Receptors, Opioid, delta; Structure-Activity Relationship | 1989 |
Naltrindole, a highly selective and potent non-peptide delta opioid receptor antagonist.
Topics: Animals; Guinea Pigs; Ileum; In Vitro Techniques; Indoles; Male; Mice; Morphinans; Muscle Contraction; Muscle, Smooth, Vascular; Naltrexone; Narcotic Antagonists; Rats; Receptors, Opioid; Receptors, Opioid, delta; Vas Deferens | 1988 |
Characterization of the opioid receptor subtypes mediating the negative inotropic effects of DAMGO, DPDPE and U-50, 488H in isolated human right atria strips.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adult; Aged; Analgesics; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Heart Atria; Humans; Male; Middle Aged; Myocardial Contraction; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pyrrolidines; Receptors, Opioid | 1995 |
Differential modulation of alpha 2-adrenergic and mu-opioid spinal antinociception by neuropeptide FF.
Topics: Adrenergic alpha-Agonists; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Synergism; Imidazoles; Male; Medetomidine; Morphine; Naltrexone; Narcotic Antagonists; Neuropeptides; Oligopeptides; Pain; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Opioid, mu; Spinal Cord; Time Factors | 1995 |
The delta opioid receptor antagonist naltrindole attenuates both alcohol and saccharin intake in rats selectively bred for alcohol preference.
Topics: Alcohol Drinking; Animals; Drinking; Eating; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid, delta; Saccharin | 1995 |
Cocaine self-administration and naltrindole, a delta-selective opioid antagonist.
Topics: Animals; Cocaine; Conditioning, Operant; Drug Implants; Female; Male; Morphine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; Receptors, Opioid, delta; Self Administration | 1995 |
The delta-opioid receptor antagonist naltrindole prevents sensitization to the conditioned rewarding effects of cocaine.
Topics: Animals; Association Learning; Cocaine; Conditioning, Operant; Drug Interactions; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Reward; Sensitivity and Specificity | 1995 |
Involvement of delta 1-opioid receptors in the antinociceptive effects of mexiletine in mice.
Topics: Animals; Diabetic Neuropathies; Male; Mexiletine; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Pain; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reference Values | 1995 |
Activity at phencyclidine and mu opioid sites mediates the hyperalgesic and antinociceptive properties of the N-terminus of substance P in a model of visceral pain.
Topics: Animals; Biological Assay; Disease Models, Animal; Dizocilpine Maleate; Hyperalgesia; Injections, Spinal; Injections, Subcutaneous; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Peptide Fragments; Phencyclidine; Receptors, Opioid, mu; Spinal Cord; Substance P | 1994 |
Species and age-dependent differences of functional coupling between opioid delta-receptor and G-proteins and possible involvement of protein kinase C in striatal membranes.
Topics: Aging; Analgesics; Animals; Carbazoles; Cell Membrane; Corpus Striatum; Cyclic AMP-Dependent Protein Kinases; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; GTP Phosphohydrolases; GTP-Binding Proteins; Guinea Pigs; Indoles; Kinetics; Male; Naltrexone; Naphthalenes; Polycyclic Compounds; Protein Kinase C; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Species Specificity | 1994 |
Characterization of the spinal antinociceptive activity of constrained peptidomimetic opioids.
Topics: Amino Acid Sequence; Analgesia; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Endorphins; Enkephalins; Injections, Spinal; Male; Mice; Molecular Sequence Data; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Oligopeptides; Opioid Peptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord; Structure-Activity Relationship; Vas Deferens | 1995 |
Effect of naltrindole on the development of physical dependence on morphine in mice: a behavioral and biochemical study.
Topics: Animals; Behavior, Animal; Body Weight; Male; Mice; Mice, Inbred Strains; Morphine Dependence; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Sodium Chloride; Time Factors | 1995 |
Synthesis of radioiodinated naltrindole analogues: ligands for studies of delta opioid receptors.
Topics: Chromatography, High Pressure Liquid; Iodine Radioisotopes; Isotope Labeling; Ligands; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Spectrophotometry, Ultraviolet; Tomography, Emission-Computed, Single-Photon | 1995 |
Selective actions of central mu and kappa opioid antagonists upon sucrose intake in sham-fed rats.
Topics: Animals; Cerebral Ventricles; Eating; Enkephalin, Leucine-2-Alanine; Infusions, Parenteral; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sucrose | 1995 |
Inhibition of luteinizing hormone-releasing hormone secretion by delta-opioid agonists in GT1-1 neuronal cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Alprostadil; Amino Acid Sequence; Cell Line; Colforsin; Culture Media, Conditioned; Dinoprostone; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gonadotropin-Releasing Hormone; Molecular Sequence Data; Naltrexone; Narcotic Antagonists; Neurons; Pyrrolidines; Receptors, Opioid, delta | 1995 |
Human delta opioid receptor: a stable cell line for functional studies of opioids.
Topics: Animals; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Humans; Naltrexone; Radioligand Assay; Receptors, Opioid, delta; Recombinant Proteins | 1995 |
mu- and delta-opioid receptor-mediated contractile effects on rat aortic vascular smooth muscle.
Topics: Amino Acid Sequence; Analgesics; Analysis of Variance; Animals; Aorta; Benzomorphans; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Molecular Sequence Data; Morphine; Muscle Contraction; Muscle, Smooth, Vascular; Naltrexone; Norepinephrine; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu | 1995 |
The antinociception induced by beta-endorphin administered intrathecally is mediated by the activation of mu- and kappa-opioid receptors in the rat.
Topics: Animals; beta-Endorphin; Dose-Response Relationship, Drug; Injections, Spinal; Male; Naltrexone; Nociceptors; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin; Tail; Time Factors | 1995 |
Delta opioid agonists inhibit proliferation of highlypurified murine CD4+ and CD8+ T-cells.
Topics: Analgesics; Animals; CD4 Antigens; CD8 Antigens; Cell Division; Cells, Cultured; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Female; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; T-Lymphocytes | 1995 |
Formalin-induced nociceptive responses in diabetic mice.
Topics: Analgesics; Animals; Behavior, Animal; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Formaldehyde; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Nociceptors; Receptors, Opioid, delta; Substance P | 1993 |
Differential involvement of ventral tegmental mu, delta and kappa opioid receptors in modulation of basal mesolimbic dopamine release: in vivo microdialysis studies.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; 3,4-Dihydroxyphenylacetic Acid; Amino Acid Sequence; Analgesics; Animals; Chromatography, High Pressure Liquid; Corpus Striatum; Dialysis; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Homovanillic Acid; Hydroxyindoleacetic Acid; Limbic System; Male; Microinjections; Molecular Sequence Data; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Tegmentum Mesencephali | 1993 |
Antisense oligodeoxynucleotide to the CCKB receptor produces naltrindole- and [Leu5]enkephalin antiserum-sensitive enhancement of morphine antinociception.
Topics: Animals; Drug Synergism; Enkephalin, Leucine; Immune Sera; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Narcotic Antagonists; Nociceptors; Oligonucleotides, Antisense; Receptors, Cholecystokinin | 1994 |
Analysis of central opioid receptor subtype antagonism of hypotonic and hypertonic saline intake in water-deprived rats.
Topics: Animals; Enkephalin, Leucine-2-Alanine; Hypotonic Solutions; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Saline Solution, Hypertonic; Water Deprivation | 1995 |
Evidence for functional delta-opiate receptors in the rat intestine.
Topics: Acetylcholine; Animals; Cricetinae; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; In Vitro Techniques; Jejunum; Male; Mice; Muscle Contraction; Muscle, Smooth; Naltrexone; Rats; Rats, Wistar; Receptors, Opioid, delta | 1994 |
A lack of supersensitivity to opioid receptor agonists following chronic spinal opioid receptor antagonist administration in the rat.
Topics: Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Somatostatin; Species Specificity; Spinal Cord | 1995 |
SNC 80, a selective, nonpeptidic and systemically active opioid delta agonist.
Topics: Analgesics; Animals; Behavior, Animal; Benzamides; Guinea Pigs; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Naltrexone; Piperazines; Radioligand Assay; Receptors, Opioid, delta | 1995 |
The increase in morphine antinociceptive potency produced by carrageenan-induced hindpaw inflammation is blocked by naltrindole, a selective delta-opioid antagonist.
Topics: Animals; Carrageenan; Hindlimb; Inflammation; Male; Morphine; Naltrexone; Nociceptors; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta | 1995 |
A selective CCKB receptor antagonist potentiates, mu-, but not delta-opioid receptor-mediated antinociception in the formalin test.
Topics: Analgesics; Animals; Disulfides; Enkephalins; Formaldehyde; Indoles; Male; Meglumine; Mice; Morphine; Naloxone; Naltrexone; Pain Measurement; Phenylalanine; Receptors, Cholecystokinin; Receptors, Opioid, delta; Receptors, Opioid, mu | 1995 |
CCKA, but not CCKB, agonists suppress the hyperlocomotion induced by endogenous enkephalins, protected from enzymatic degradation by systemic RB 101.
Topics: Amino Acid Sequence; Animals; Benzodiazepinones; Cholecystokinin; Devazepide; Disulfides; Enkephalins; Enzyme Inhibitors; Male; Mice; Molecular Sequence Data; Motor Activity; Naltrexone; Narcotic Antagonists; Peptide Fragments; Phenylalanine; Receptors, Cholecystokinin | 1995 |
Assessment of endogenous enkephalins efficacy in the hot plate test in mice: comparative study with morphine.
Topics: Animals; Dose-Response Relationship, Drug; Enkephalins; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Receptors, Opioid, mu | 1995 |
Endogenous opioids regulate long-term potentiation of synaptic inhibition in the dentate gyrus of rat hippocampus.
Topics: 2-Amino-5-phosphonovalerate; Animals; Bicuculline; Electric Stimulation; GABA-A Receptor Antagonists; Hippocampus; Homeostasis; In Vitro Techniques; Long-Term Potentiation; Male; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Opioid Peptides; Patch-Clamp Techniques; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Synapses; Time Factors | 1995 |
Unexpected prosecretory action component of loperamide at mu-opioid receptors in the guinea-pig colonic mucosa in vitro.
Topics: Alprostadil; Amino Acid Sequence; Animals; Chlorides; Colon; Dose-Response Relationship, Drug; Ethylketocyclazocine; Guinea Pigs; Intestinal Mucosa; Loperamide; Male; Molecular Sequence Data; Naloxone; Naltrexone; Patch-Clamp Techniques; Receptors, Opioid, delta; Receptors, Opioid, mu; Somatostatin; Theophylline | 1995 |
Antinociceptive effect of dihydroetorphine in diabetic mice.
Topics: Analgesia; Analgesics, Opioid; Animals; Binding, Competitive; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Etorphine; Injections, Intraperitoneal; Injections, Intraventricular; Injections, Subcutaneous; Male; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Receptors, Opioid, delta; Receptors, Opioid, mu | 1995 |
Evidence that beta-endorphin is an agonist at bovine pineal delta-opioid receptors.
Topics: Animals; beta-Endorphin; Binding, Competitive; Cattle; Dose-Response Relationship, Drug; Guanylyl Imidodiphosphate; In Vitro Techniques; Naloxone; Naltrexone; Pineal Gland; Receptors, Opioid, delta | 1995 |
Delta-opioid receptor agonists inhibit neuromuscular transmission in human colon.
Topics: Analgesics; Analgesics, Opioid; Colon; Dynorphins; Electric Stimulation; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Gastrointestinal Motility; Humans; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Neuromuscular Junction; Peptide Fragments; Receptors, Opioid, delta; Synaptic Transmission | 1994 |
Effects of diabetes on spontaneous locomotor activity in mice.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Benzazepines; Benzylidene Compounds; Brain; Corpus Striatum; Diabetes Mellitus, Experimental; Dopamine; Haloperidol; Homovanillic Acid; Male; Mice; Mice, Inbred ICR; Motor Activity; Naltrexone; Narcotic Antagonists; Prosencephalon; Receptors, Dopamine D1; Receptors, Opioid, delta; Reference Values | 1994 |
Attenuation of the discriminative stimulus properties of cocaine by delta-opioid receptor antagonists.
Topics: Animals; Benzylidene Compounds; Cocaine; Discrimination Learning; Dose-Response Relationship, Drug; Male; Naltrexone; Rats; Rats, Inbred F344; Receptors, Opioid, delta | 1994 |
Repeated acquisition of behavioral chains in squirrel monkeys: comparisons of a mu, kappa and delta opioid agonist.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzamides; Conditioning, Operant; Dose-Response Relationship, Drug; Female; Morphine; Naltrexone; Piperazines; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Saimiri | 1995 |
7'-Substituted amino acid conjugates of naltrindole. Hydrophilic groups as determinants of selective antagonism of delta 1 opioid receptor-mediated antinociception in mice.
Topics: Amino Acids; Analgesics; Animals; Guinea Pigs; In Vitro Techniques; Male; Mice; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Structure-Activity Relationship | 1995 |
The effect of chronic treatment with naltrindole, a selective delta-opioid antagonist, on mu-opioid receptor-mediated antinociception in diabetic mice.
Topics: Analgesics; Animals; Diabetes Mellitus, Experimental; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intraventricular; Injections, Subcutaneous; Male; Mice; Mice, Inbred ICR; Monocytes; Morphine; Naltrexone; Narcotic Antagonists; Pain Measurement; Receptors, Opioid, delta; Receptors, Opioid, mu; Spleen | 1993 |
Blockade of delta-opioid receptors prevents morphine-induced place preference in mice.
Topics: Analgesics; Animals; Benzylidene Compounds; Conditioning, Operant; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Mice, Inbred Strains; Morphine; Naltrexone; Narcotic Antagonists; Oligopeptides; Receptors, Opioid, delta; Receptors, Opioid, mu | 1994 |
Delta-opiod receptor-mediated forced swimming stress-induced antinociception in the formalin test.
Topics: Animals; Formaldehyde; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Nociceptors; Pain Measurement; Receptors, Opioid, delta; Stress, Psychological; Swimming | 1993 |
Antagonism of the morphine-induced Straub tail reaction by kappa-opioid receptor activation in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Dose-Response Relationship, Drug; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Morphine; Naltrexone; Narcotic Antagonists; Pain Measurement; Pyrrolidines; Receptors, Opioid, kappa | 1993 |
Involvement of delta-opioid receptors in the effects of morphine on locomotor activity and the mesolimbic dopaminergic system in mice.
Topics: 3,4-Dihydroxyphenylacetic Acid; Analgesics; Animals; Dopamine; Homovanillic Acid; Limbic System; Male; Mice; Mice, Inbred Strains; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Postural Balance; Reaction Time; Receptors, Opioid, delta | 1993 |
Effects of the delta-opioid agonist, [D-Pen2,D-Pen5]-enkephalin, on fetal lamb EEG.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Electroencephalography; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Fetus; Injections, Intraventricular; Naltrexone; Narcotic Antagonists; Pregnancy; Receptors, Opioid, delta; Sheep | 1994 |
Peripheral effects of naloxone in mice with acute diarrhea associated with intestinal inflammation.
Topics: Acute Disease; Animals; Benzomorphans; Croton Oil; Diarrhea; Enteritis; Gastrointestinal Motility; Male; Mice; Naloxone; Naltrexone; Quaternary Ammonium Compounds; Receptors, Opioid, delta; Receptors, Opioid, kappa | 1995 |
Naltrindole, an opioid delta antagonist, blocks the enhancement of morphine-antinociception induced by a CCKB antagonist in the rat.
Topics: Animals; Benzodiazepinones; Injections, Spinal; Injections, Subcutaneous; Male; Morphine; Naltrexone; Narcotic Antagonists; Nociceptors; Pain Measurement; Phenylurea Compounds; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Receptors, Opioid, delta | 1994 |
Differential regulation of adenylyl cyclase activity by mu and delta opioids in rat caudate putamen and nucleus accumbens.
Topics: Adenylyl Cyclases; Amino Acid Sequence; Animals; Benzeneacetamides; Caudate Nucleus; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Male; Molecular Sequence Data; Naloxone; Naltrexone; Nucleus Accumbens; Oligopeptides; Putamen; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Signal Transduction; Somatostatin | 1993 |
Opioid thermal antinociception in rhesus monkeys: receptor mechanisms and temperature dependency.
Topics: Alfentanil; Analgesics; Animals; Azocines; Benzimidazoles; Benzomorphans; Dose-Response Relationship, Drug; Female; Hot Temperature; Macaca mulatta; Male; Nalbuphine; Naltrexone; Nociceptors; Pyrrolidines; Receptors, Opioid; Tail | 1993 |
Mechanism of action of CCK in avian gastroduodenal motility: evidence for nitric oxide involvement.
Topics: Animals; Arginine; Atropine; Chickens; Duodenum; Electromyography; Female; Gastrointestinal Motility; Hexamethonium; Hexamethonium Compounds; Male; Membrane Potentials; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Phentolamine; Propranolol; Sincalide; Stomach; Vagotomy | 1993 |
Etonitazene-induced antinociception in mu1 opioid receptor deficient CXBK mice: evidence for a role for mu2 receptors in supraspinal antinociception.
Topics: Animals; Benzimidazoles; Cerebral Ventricles; Dose-Response Relationship, Drug; Enkephalin, Leucine; Hot Temperature; Injections, Intraventricular; Injections, Subcutaneous; Male; Mice; Mice, Inbred ICR; Mice, Mutant Strains; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Receptors, Opioid, mu; Spinal Cord | 1994 |
Central administration of the endopeptidase 24.15 inhibitor cFP-AAF-pAB suggests dynorphin as the endogenous ligand underlying behavioral effects of milk in the fetal rat.
Topics: Amino Acid Sequence; Animals; Behavior, Animal; Cisterna Magna; Dynorphins; Female; Fetus; Injections; Ligands; Metalloendopeptidases; Milk; Molecular Sequence Data; Naltrexone; Narcotic Antagonists; Oligopeptides; Physical Stimulation; Pregnancy; Rats; Rats, Sprague-Dawley; Somatostatin | 1994 |
Effects of mu, delta and kappa opioid antagonists on the depression of a C-fiber reflex by intrathecal morphine and DAGO in the rat.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Spinal; Morphine; Naltrexone; Narcotic Antagonists; Nerve Fibers; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reflex; Somatostatin | 1994 |
Semiparametric models for antagonistic drug interactions.
Topics: Animals; Binding, Competitive; Drug Antagonism; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intraventricular; Models, Biological; Naltrexone; Narcotic Antagonists; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Somatostatin | 1994 |
The kappa agonist fedotozine modulates colonic distention-induced inhibition of gastric motility and emptying in dogs.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzyl Compounds; Bretylium Compounds; Catheterization; Colon; Dogs; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Gastric Emptying; Gastrointestinal Motility; Granisetron; Hexamethonium; Male; Naltrexone; Narcotic Antagonists; Propylamines; Pyrrolidines; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reflex; Stomach | 1994 |
Behavioral effects of the systemically active delta opioid agonist BW373U86 in rhesus monkeys.
Topics: Analgesics; Animals; Behavior, Animal; Benzamides; Female; Macaca mulatta; Male; Naltrexone; Narcotic Antagonists; Piperazines; Receptors, Opioid, delta; Respiration | 1994 |
The involvement of opioid delta receptor in restraint-induced antinociception in mice.
Topics: Animals; Female; Male; Mice; Mice, Inbred CFTR; Morphine; Naltrexone; Narcotic Antagonists; Nociceptors; Pain Measurement; Receptors, Opioid, delta; Receptors, Opioid, mu; Restraint, Physical; Sex Factors | 1994 |
The role of delta-opioid receptor subtypes in cocaine- and methamphetamine-induced place preferences.
Topics: Animals; Benzylidene Compounds; Cocaine; Conditioning, Psychological; Male; Methamphetamine; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Reinforcement, Psychology | 1994 |
Differential modulation of behavioral responses by [D-Ala2, NMePhe4, Gly-ol]enkephalin, [D-Ala2] deltorphin II and [D-Pen2, L-Pen5]enkephalin in the mouse.
Topics: Analysis of Variance; Animals; Behavior, Animal; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Mice, Inbred Strains; Naltrexone; Oligopeptides | 1994 |
Theoretical conformational analysis of the opioid delta antagonist H-Tyr-Tic-Phe-OH and the mu agonist H-Tyr-D-Tic-Phe-NH2.
Topics: Amino Acid Sequence; Isoquinolines; Molecular Sequence Data; Naltrexone; Oligopeptides; Protein Conformation; Receptors, Opioid, delta; Receptors, Opioid, mu; Tetrahydroisoquinolines; Thermodynamics | 1994 |
The effect of naltrindole on spinal and supraspinal delta opioid receptors and analgesia.
Topics: Analgesia; Analgesics; Animals; Brain; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Injections, Intraventricular; Injections, Spinal; Kinetics; Male; Mice; Naltrexone; Pain Measurement; Receptors, Opioid, delta; Spinal Cord | 1994 |
Morphine reduces the release of met-enkephalin-like material from the rat spinal cord in vivo by acting at delta opioid receptors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Injections, Spinal; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pyrrolidines; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Spinal Cord | 1994 |
Role of endogenous cholecystokinin in the facilitation of mu-mediated antinociception by delta-opioid agonists.
Topics: Amino Acid Sequence; Analgesia; Animals; Benzodiazepinones; Cholecystokinin; Devazepide; Disulfides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Mice; Molecular Sequence Data; Naloxone; Naltrexone; Oligopeptides; Peptide Fragments; Phenylalanine; Receptors, Opioid, delta; Receptors, Opioid, mu; Sincalide | 1994 |
Antidepressant-like effects of CCKB antagonists in mice: antagonism by naltrindole.
Topics: Amino Acid Sequence; Animals; Antidepressive Agents; Behavior, Animal; Benzodiazepinones; Cholecystokinin; Conditioning, Classical; Drug Interactions; Male; Mice; Molecular Sequence Data; Motor Activity; Naltrexone; Peptide Fragments; Phenylurea Compounds; Receptors, Cholecystokinin | 1994 |
Synthesis and delta-opioid receptor antagonist activity of a naltrindole analogue with a regioisomeric indole moiety.
Topics: Animals; Guinea Pigs; In Vitro Techniques; Indoles; Isomerism; Mice; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta | 1994 |
Agonists and antagonists bind to different domains of the cloned kappa opioid receptor.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Base Sequence; Benzeneacetamides; Binding Sites; Cell Line; Chlorocebus aethiops; Cloning, Molecular; Colforsin; Cyclic AMP; Enkephalin, Leucine; Kinetics; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Naloxone; Naltrexone; Oligodeoxyribonucleotides; Protein Structure, Secondary; Pyrrolidines; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, kappa; Recombinant Fusion Proteins; Recombinant Proteins; Transfection | 1994 |
The use of specific opioid agonists and antagonists to delineate the vagally mediated antinociceptive and cardiovascular effects of intravenous morphine.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analysis of Variance; Animals; Blood Pressure; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Heart Rate; Hexamethonium; Hexamethonium Compounds; Indoles; Injections, Intravenous; Male; Morphinans; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pain; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reference Values; Time Factors; Vagotomy; Vagus Nerve | 1993 |
Mu- vs. delta-opioid influence on respiratory and sleep behavior during development.
Topics: Aging; Animals; Blood Pressure; Dose-Response Relationship, Drug; Electromyography; Growth; Heart Rate; Hydrogen-Ion Concentration; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Receptors, Opioid, mu; Respiration; Respiratory Physiological Phenomena; Respiratory System; Sleep; Somatostatin; Swine; Swine, Miniature | 1993 |
Activation of spinal delta-1 or delta-2 opioid receptors reduces carrageenan-induced hyperalgesia in the rat.
Topics: Animals; Carrageenan; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hyperalgesia; Male; Naltrexone; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Spinal Cord | 1994 |
Characterization of [3H]naltrindole binding to delta opioid receptors in mouse brain and mouse vas deferens: evidence for delta opioid receptor heterogeneity.
Topics: Animals; Brain; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guanylyl Imidodiphosphate; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Vas Deferens | 1994 |
The effects of selective blockade of delta and mu opiate receptors on ethanol consumption by C57BL/6 mice in a restricted access paradigm.
Topics: Alcohol Drinking; Animals; Mice; Mice, Inbred C57BL; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Receptors, Opioid, mu | 1993 |
Synthesis of naltrexone-derived delta-opioid antagonists. Role of conformation of the delta address moiety.
Topics: Animals; Benzylidene Compounds; Electric Stimulation; Guinea Pigs; Ileum; Male; Mice; Models, Molecular; Molecular Conformation; Molecular Structure; Muscle, Smooth; Naltrexone; Receptors, Opioid, delta; Structure-Activity Relationship; Vas Deferens | 1994 |
The effect of norbinaltorphimine, beta-funaltrexamine and naltrindole on NPY-induced feeding.
Topics: Animals; Eating; Injections, Intraventricular; Male; Naltrexone; Narcotic Antagonists; Neuropeptide Y; Rats; Rats, Sprague-Dawley | 1993 |
Antinociceptive effect of lipopolysaccharide from Pantoea agglomerans on streptozotocin-induced diabetic mice.
Topics: Analgesics; Animals; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Enterobacter; Injections, Subcutaneous; Lipopolysaccharides; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Pain Measurement | 1994 |
The decompensatory phase of acute hypovolaemia in rabbits involves a central delta 1-opioid receptor.
Topics: Animals; Benzylidene Compounds; Blood Pressure; Cardiac Output; Enkephalin, Leucine; Hemodynamics; Hemorrhage; Naltrexone; Narcotic Antagonists; Rabbits; Receptors, Opioid, delta; Shock | 1994 |
Differential modulation of angiotensin II and hypertonic saline-induced drinking by opioid receptor subtype antagonists in rats.
Topics: Angiotensin II; Animals; Drinking; Enkephalin, Leucine-2-Alanine; Male; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Saline Solution, Hypertonic | 1994 |
Influence of selective opiate antagonists on striatal acetylcholine and dopamine release.
Topics: Acetylcholine; Animals; Corpus Striatum; Dopamine; Electric Stimulation; In Vitro Techniques; Male; Naloxone; Naltrexone; Narcotic Antagonists; Oxidopamine; Rats; Rats, Wistar | 1993 |
The effect of selective opioid antagonists on butorphanol-induced feeding.
Topics: Animals; Butorphanol; Dose-Response Relationship, Drug; Feeding Behavior; Injections, Intraventricular; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1994 |
The role of multiple opioid receptors in the maintenance of stimulation-induced feeding.
Topics: Amino Acid Sequence; Animals; Differential Threshold; Dose-Response Relationship, Drug; Eating; Electric Stimulation; Hypothalamic Area, Lateral; Male; Molecular Sequence Data; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid | 1994 |
Antitussive effect of [Met5]enkephalin-Arg6-Phe7 in mice.
Topics: Animals; Antitussive Agents; Capsaicin; Cough; Dose-Response Relationship, Drug; Enkephalin, Methionine; Injections, Intraventricular; Male; Mice; Naltrexone; Narcotic Antagonists; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1994 |
Identification of a human delta opioid receptor: cloning and expression.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Line; Cloning, Molecular; Consensus Sequence; Enkephalins; Humans; Mice; Molecular Sequence Data; Naltrexone; Narcotic Antagonists; Oligopeptides; Open Reading Frames; Receptors, Opioid, delta; Sequence Alignment; Transfection | 1994 |
The role of multiple opioid receptors in the potentiation of reward by food restriction.
Topics: Animals; Behavior, Animal; Brain; Conditioning, Operant; Dose-Response Relationship, Drug; Food Deprivation; Injections, Intraventricular; Male; Naltrexone; Narcotic Antagonists; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reward; Self Stimulation | 1994 |
Antinociceptive effect of L-arginine in diabetic mice.
Topics: Analgesics; Animals; Arginine; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Endorphins; Injections, Intraventricular; Injections, Subcutaneous; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Nitroarginine; Pain Measurement; Reaction Time | 1994 |
Antinociceptive effect of dihydroetorphine and its tolerance/dependence liability in mice.
Topics: Analgesics; Animals; Body Weight; Drug Tolerance; Etorphine; Male; Mice; Mice, Inbred Strains; Morphine; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Substance-Related Disorders | 1993 |
Differential effects of specific delta and kappa opioid receptor antagonists on the bidirectional dose-dependent effect of systemic naloxone in arthritic rats, an experimental model of persistent pain.
Topics: Analysis of Variance; Animals; Arthritis; Benzomorphans; Dose-Response Relationship, Drug; Injections, Intravenous; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Pain; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Vocalization, Animal | 1993 |
Binding of BW 373U86, a non-peptidic delta opioid receptor agonist, is not regulated by guanine nucleotides and sodium.
Topics: Animals; Benzamides; Binding, Competitive; Brain; Guanine Nucleotides; Male; Membranes; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Piperazines; Radioligand Assay; Receptors, Opioid, delta; Sodium; Vas Deferens | 1993 |
Delta opioid receptor mediates phospholipase C activation via Gi in Xenopus oocytes.
Topics: Analgesics; Animals; Benzeneacetamides; Electric Conductivity; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Enzyme Activation; Female; Gene Expression; GTP-Binding Proteins; Membrane Potentials; Mice; Naltrexone; Narcotic Antagonists; Oocytes; Pyrrolidines; Receptors, Opioid, delta; Type C Phospholipases; Xenopus laevis | 1993 |
A novel delta opioid agonist, BW373U86, in squirrel monkeys responding under a schedule of shock titration.
Topics: Amino Acid Sequence; Animals; Behavior, Animal; Benzamides; Drug Interactions; Drug Tolerance; Electroshock; Male; Methadone; Molecular Sequence Data; Naltrexone; Narcotic Antagonists; Nociceptors; Piperazines; Receptors, Opioid, delta; Receptors, Opioid, mu; Saimiri | 1993 |
Binding in vivo of selective mu and delta opioid agonists: localization by autoradiography.
Topics: Amino Acid Sequence; Analgesics; Animals; Autoradiography; Binding, Competitive; Brain; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Diffusion; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intraventricular; Male; Mice; Molecular Sequence Data; Naltrexone; Oligopeptides; Pain Measurement; Protein Binding; Receptors, Opioid, delta; Receptors, Opioid, mu | 1993 |
Medullary mu and delta opioid receptors modulate mesencephalic morphine analgesia in rats.
Topics: Analgesics; Animals; Male; Medulla Oblongata; Mesencephalon; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu | 1993 |
Inhibition of cocaine-induced sensitization by the delta-opioid receptor antagonist naltrindole.
Topics: Animals; Cocaine; Male; Motor Activity; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta | 1993 |
delta-Opioid receptor-mediated regulation of central dopaminergic neurons in the rat.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Dihydroxyphenylalanine; Dopamine; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Naltrexone; Narcotic Antagonists; Neurons; Rats; Receptors, Opioid, delta | 1993 |
Antitussive effects of naltrindole, a selective delta-opioid receptor antagonist, in mice and rats.
Topics: Animals; Antitussive Agents; Capsaicin; Cough; Drug Interactions; Endorphins; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa | 1993 |
Delta-opioid receptor antagonists attenuate motor activity induced by amphetamine but not cocaine.
Topics: Amphetamine; Animals; Cocaine; Dose-Response Relationship, Drug; Enkephalin, Leucine-2-Alanine; Male; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta | 1993 |
Delta-1 opioid receptor dependence of acute hypoxic adaptation.
Topics: Adaptation, Physiological; Animals; Benzylidene Compounds; Hypoxia; Male; Mice; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta | 1994 |
Evidence for delta opioid receptor subtypes regulating adenylyl cyclase activity in rat brain.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Analgesics; Animals; Benzylidene Compounds; Caudate Nucleus; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Male; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta | 1994 |
Opioid receptors-mediated respiratory effects and antinociception after S(+)-ketamine.
Topics: Animals; Dogs; Dose-Response Relationship, Drug; Electroencephalography; Evoked Potentials, Somatosensory; Ketamine; Naltrexone; Narcotic Antagonists; Nociceptors; Receptors, Opioid; Respiration; Stereoisomerism; Wakefulness | 1993 |
The role of endogenous opioids as mediators of the hypothermic effects of intrathecally administered calcium and calcitonin gene-related peptide in mice.
Topics: Animals; Body Temperature Regulation; Calcitonin Gene-Related Peptide; Calcium; Dose-Response Relationship, Drug; Drug Interactions; Endorphins; Hypothalamus; Hypothermia, Induced; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Time Factors | 1993 |
Effect of diabetes on the antinociceptive effect of beta-endorphin.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; beta-Endorphin; Cerebral Ventricles; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Pain; Pyrrolidines; Reference Values | 1993 |
A remarkable change of opioid receptor selectivity on the attachment of a peptidomimetic kappa address element to the delta antagonist, natrindole: 5'-[N2-alkylamidino)methyl]naltrindole derivatives as a novel class of kappa opioid receptor antagonists.
Topics: Animals; Guinea Pigs; Indoles; Morphinans; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Receptors, Opioid, kappa; Structure-Activity Relationship | 1993 |
Blockade of delta-opioid receptors in the nucleus accumbens prevents ethanol-induced stimulation of dopamine release.
Topics: Animals; Cocaine; Dopamine; Ethanol; Indoles; Male; Morphinans; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta | 1993 |
Opioid-induced stimulation of fetal respiratory activity by [D-Ala2]deltorphin I.
Topics: Animals; Dose-Response Relationship, Drug; Electromyography; Female; Fetus; Indoles; Injections, Intraventricular; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pregnancy; Receptors, Opioid, delta; Respiration; Sheep | 1993 |
Electrophysiological actions of delta opioids in CA1 of the rat hippocampal slice are mediated by one delta receptor subtype.
Topics: Analgesics; Animals; Electric Stimulation; Electrophysiology; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Evoked Potentials; Hippocampus; In Vitro Techniques; Indoles; Ligands; Male; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Pyramidal Tracts; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu | 1993 |
Naltrindole, an opioid delta receptor antagonist, blocks cocaine-induced facilitation of responding for rewarding brain stimulation.
Topics: Analysis of Variance; Animals; Brain; Cocaine; Electric Stimulation; Indoles; Male; Morphinans; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Reinforcement, Psychology; Self Stimulation | 1993 |
Immunosuppression by delta opioid receptor antagonist.
Topics: Animals; Fluorescent Antibody Technique; Graft Survival; Immunosuppressive Agents; Indoles; Kidney Transplantation; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Lymphocytes; Morphinans; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred BN; Rats, Inbred Lew; Receptors, Opioid, delta; Spleen; Time Factors; Transplantation, Homologous | 1993 |
Cocaine-like discriminative stimulus properties of the delta-selective opioid receptor agonist, [D-Pen2,L-Pen5]enkephalin, in the rat.
Topics: Animals; Cocaine; Discrimination Learning; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Generalization, Stimulus; Indoles; Morphinans; Naltrexone; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu | 1993 |
Quantitative light microscopic localization of [3H]naltrindole binding sites in the rat brain.
Topics: Animals; Autoradiography; Binding Sites; Brain Chemistry; In Vitro Techniques; Indoles; Male; Microscopy; Morphinans; Naltrexone; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Tritium | 1993 |
Opioid antagonists and butorphanol dependence.
Topics: Animals; Behavior, Animal; Butorphanol; Indoles; Injections, Intraventricular; Male; Morphinans; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Substance Withdrawal Syndrome | 1993 |
Involvement of mu1 and mu2 opioid receptor subtypes in tail-pinch feeding in rats.
Topics: Animals; Arousal; Enkephalin, Leucine-2-Alanine; Feeding Behavior; Indoles; Male; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 1993 |
[3H]naltrindole: a potent and selective ligand for labeling delta-opioid receptors.
Topics: Animals; Binding, Competitive; Brain; Indoles; Kinetics; Male; Morphinans; Naltrexone; Narcotic Antagonists; Narcotics; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Thermodynamics; Tritium | 1993 |
Differential modulation of mu-opioid receptor-mediated antitussive activity by delta-opioid receptor agonists in mice.
Topics: Animals; Antitussive Agents; Cough; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Oligopeptides; Receptors, Opioid, delta; Receptors, Opioid, mu | 1993 |
Spinal delta 2 but not delta 1 opioid receptors are involved in intracerebroventricular beta-endorphin-induced antinociception in the mouse.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzylidene Compounds; beta-Endorphin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Nociceptors; Pain Measurement; Pyrrolidines; Receptors, Opioid, delta; Spinal Cord | 1993 |
L-arginine exerts a dual role in nociceptive processing in the brain: involvement of the kyotorphin-Met-enkephalin pathway and NO-cyclic GMP pathway.
Topics: Analgesics; Animals; Arginine; Brain; Cyclic GMP; Endorphins; Enkephalin, Methionine; Injections, Intraventricular; Male; Methylene Blue; Mice; Mice, Inbred Strains; Naloxone; Naltrexone; Narcotic Antagonists; Neural Pathways; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nociceptors; Pain Measurement; Spinal Cord | 1993 |
Opioid control of the release of calcitonin gene-related peptide-like material from the rat spinal cord in vivo.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Calcitonin Gene-Related Peptide; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Spinal; Iodine Radioisotopes; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pyrrolidines; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1993 |
Effect of antagonists selective for mu, delta and kappa opioid receptors on the reinforcing effects of heroin in rats.
Topics: Animals; Heroin; Male; Naloxone; Naltrexone; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Self Administration | 1993 |
Dose-dependent antagonism of spinal opioid receptor agonists by naloxone and naltrindole: additional evidence for delta-opioid receptor subtypes in the rat.
Topics: Analgesics; Animals; Binding, Competitive; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; In Vitro Techniques; Injections, Spinal; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord | 1993 |
The highly selective delta agonist BUBU induces an analgesic effect in normal and arthritic rat and this action is not affected by repeated administration of low doses of morphine.
Topics: Analgesics; Animals; Arthritis, Experimental; Drug Administration Schedule; Drug Interactions; Enkephalins; Male; Morphine; Naloxone; Naltrexone; Oligopeptides; Pain; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Reference Values; Vocalization, Animal | 1993 |
Involvement of spinal kappa opioid receptors in a type of footshock induced analgesia in mice.
Topics: Analgesia; Animals; Cerebral Ventricles; Electroshock; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Receptors, Opioid, kappa; Spinal Cord; Stress, Psychological | 1993 |
Selective opioid receptor agonists modulate mechanical allodynia in an animal model of neuropathic pain.
Topics: Analgesics; Animals; Benzeneacetamides; Benzomorphans; Disease Models, Animal; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain; Pain Measurement; Pain Threshold; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vocalization, Animal | 1993 |
Effect of delayed weaning on opioid receptor control of swim stress-induced antinociception in the developing rat.
Topics: Alfentanil; Analgesia; Animals; Female; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Rats; Rats, Wistar; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Stress, Psychological; Swimming; Weaning | 1993 |
Antitussive effects of mu- and kappa-agonists in diabetic rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Antitussive Agents; Diabetes Mellitus, Experimental; Male; Morphine; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1993 |
Role of mu 1- and delta-opioid receptors in modulation of fetal EEG and respiratory activity.
Topics: Animals; Electroencephalography; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fetal Movement; Fetus; Morphine; Naloxone; Naltrexone; Receptors, Opioid, delta; Receptors, Opioid, mu; Respiration; Sheep | 1993 |
Isobolographic superadditivity between delta and mu opioid agonists in the rat depends on the ratio of compounds, the mu agonist and the analgesic assay used.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Synergism; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Morphine; Naltrexone; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu | 1993 |
Central opioid receptor subtype antagonists differentially reduce intake of saccharin and maltose dextrin solutions in rats.
Topics: Animals; Drinking Behavior; Enkephalin, Leucine-2-Alanine; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Polysaccharides; Rats; Rats, Sprague-Dawley; Saccharin | 1993 |
Involvement of delta-opioid receptors in physical dependence on butorphanol.
Topics: Animals; Butorphanol; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Substance-Related Disorders | 1993 |
Kinetic parameters of antagonism by the delta opioid receptor selective peptide antagonist Boc-Tyr-Pro-Gly-Phe-Leu-Thr against selective and non-selective agonists in the mouse vas deferens.
Topics: Analgesics; Animals; Anticonvulsants; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; In Vitro Techniques; Kinetics; Male; Mice; Mice, Inbred Strains; Morphine Derivatives; Naltrexone; Oligopeptides; Pyrroles; Receptors, Opioid, delta; Thiophenes; Vas Deferens | 1993 |
(D-Ala, D-Leu) enkephalin reduces the binding of GTP in hippocampal membranes.
Topics: Affinity Labels; Animals; Autoradiography; Azides; Electrophoresis, Polyacrylamide Gel; Enkephalin, Leucine-2-Alanine; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Hippocampus; In Vitro Techniques; Indoles; Male; Membranes; Morphinans; Naltrexone; Rats; Rats, Sprague-Dawley | 1993 |
Hypoxia, sleep and respiration in relation to opioids in developing swine.
Topics: Aging; Animals; Animals, Newborn; Blood Pressure; Carbon Dioxide; Diaphragm; Electromyography; Heart Rate; Hydrogen-Ion Concentration; Laryngeal Muscles; Naltrexone; Narcotic Antagonists; Narcotics; Oxygen; Respiration; Sleep; Swine | 1993 |
Lack of involvement of delta-opioid receptors in mediating the rewarding effects of cocaine.
Topics: Animals; Benzazepines; Cocaine; Conditioning, Operant; Dose-Response Relationship, Drug; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Reward; Self Administration; Time Factors | 1995 |
Attenuation of morphine tolerance and dependence with the highly selective delta-opioid receptor antagonist TIPP[psi].
Topics: Animals; Behavior, Animal; Morphine Dependence; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Rats; Receptors, Opioid, delta; Substance Withdrawal Syndrome; Tetrahydroisoquinolines | 1995 |
Opioid antagonists naloxone, beta-funaltrexamine and naltrindole, but not nor-binaltorphimine, reverse the increased hindpaw withdrawal latency in rats induced by intrathecal administration of the calcitonin gene-related peptide antagonist CGRP8-37.
Topics: Animals; Calcitonin Gene-Related Peptide; Hindlimb; Hot Temperature; Injections, Spinal; Male; Naloxone; Naltrexone; Narcotic Antagonists; Peptide Fragments; Rats; Rats, Sprague-Dawley; Reaction Time; Reflex; Stress, Mechanical | 1995 |
Suppression of immune function by non-peptidic delta opioid receptor antagonists.
Topics: Animals; B-Lymphocytes; Female; Immunosuppressive Agents; Lymphocyte Activation; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Spleen; T-Lymphocytes, Helper-Inducer | 1995 |
Electrical stimulation at traditional acupuncture sites in periphery produces brain opioid-receptor-mediated antinociception in rats.
Topics: Acupuncture Therapy; Analgesia; Animals; Brain; Electric Stimulation; Male; Naloxone; Naltrexone; Peptide Fragments; Peptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Somatostatin | 1996 |
Opioid antagonists and antisera to endogenous opioids increase the nociceptive response to formalin: demonstration of an opioid kappa and delta inhibitory tone.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Formaldehyde; Immune Sera; Male; Naloxone; Naltrexone; Narcotic Antagonists; Opioid Peptides; Pain; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa | 1996 |
In vivo labeling of delta opioid receptors in mouse brain by [3H]benzylidenenaltrexone, a ligand selective for the delta 1 subtype.
Topics: Animals; Benzylidene Compounds; Corpus Striatum; Male; Mice; Naltrexone; Radioligand Assay; Receptors, Opioid, delta; Tritium | 1996 |
Tonic endogenous opioid inhibition of visceral noxious information in rabbits.
Topics: Age Factors; Animals; Benzomorphans; Dose-Response Relationship, Drug; Female; Gastrointestinal Motility; Injections, Intramuscular; Injections, Spinal; Naloxone; Naltrexone; Narcotic Antagonists; Opioid Peptides; Rabbits; Receptors, Opioid | 1996 |
Antinociceptive and behavioral effects of synthetic deltorphin analogs.
Topics: Analysis of Variance; Animals; Catalepsy; Dose-Response Relationship, Drug; Injections, Intraventricular; Locomotion; Male; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu | 1996 |
Central antinociceptive effect of L-ornithine, a metabolite of L-arginine, in rats and mice.
Topics: Analgesia; Animals; Arginine; Carrageenan; Citrulline; Dipeptides; Dose-Response Relationship, Drug; Excipients; Hyperalgesia; Injections, Intraventricular; Leucine; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Ornithine; Pain Measurement; Protease Inhibitors; Rats | 1996 |
Differential effects of morphine-6-glucuronide, an active metabolite of morphine, and morphine on locomotor activity in mice: involvement of the opioid receptor.
Topics: Animals; Injections, Subcutaneous; Locomotion; Male; Mice; Mice, Inbred Strains; Morphine; Morphine Derivatives; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid | 1996 |
Role of delta-opioid receptors in mediating the aversive stimulus effects of morphine withdrawal in the rat.
Topics: Animals; Dose-Response Relationship, Drug; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Substance Withdrawal Syndrome | 1996 |
delta-Opioid receptor: the third extracellular loop determines naltrindole selectivity.
Topics: Animals; Base Sequence; Binding Sites; Chimera; Chlorocebus aethiops; Humans; Molecular Sequence Data; Naltrexone; Narcotic Antagonists; Polymerase Chain Reaction; Receptors, Opioid, delta; Sequence Alignment | 1996 |
Beta-endorphin enhances Concanavalin-A-stimulated calcium mobilization by murine splenic T cells.
Topics: Animals; beta-Endorphin; Biological Transport; Calcium; Concanavalin A; Enkephalin, Leucine-2-Alanine; Female; Mice; Mice, Inbred C57BL; Naltrexone; Receptors, Opioid, delta; Spleen; T-Lymphocytes | 1996 |
Ocular action of an opioid peptide, DPDPE.
Topics: Administration, Topical; Analgesics; Animals; Ciliary Body; Cyclic AMP; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Injections, Intravenous; Intraocular Pressure; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rabbits | 1996 |
Opioid receptor selectivity alteration by single residue replacement: synthesis and activity profile of [Dmt1]deltorphin B.
Topics: Animals; Mice; Muscle Contraction; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain Threshold; Rabbits; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu | 1996 |
Naltrindole, a delta-opioid antagonist, blocks MDMA's ability to enhance pressing for rewarding brain stimulation.
Topics: Animals; Brain; Electric Stimulation; Male; Medial Forebrain Bundle; N-Methyl-3,4-methylenedioxyamphetamine; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Reward; Self Stimulation; Serotonin Agents | 1996 |
Alcohol drinking is reduced by a mu 1- but not by a delta-opioid receptor antagonist in alcohol-preferring rats.
Topics: Alcohol Drinking; Animals; Dose-Response Relationship, Drug; Drinking; Eating; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraperitoneal; Male; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid, delta; Receptors, Opioid, mu | 1996 |
Human delta opioid receptor: functional studies on stably transfected Chinese hamster ovary cells after acute and chronic treatment with the selective nonpeptidic agonist SNC-80.
Topics: Animals; Benzamides; Binding, Competitive; CHO Cells; Cricetinae; Cyclic AMP; Down-Regulation; Humans; Naltrexone; Piperazines; Radioligand Assay; Receptors, Opioid, delta; Recombinant Proteins; Signal Transduction; Structure-Activity Relationship; Transfection | 1996 |
Role of opioid receptors in the spinal antinociceptive effects of neuropeptide FF analogues.
Topics: Amino Acid Sequence; Analgesics; Analgesics, Opioid; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Spinal; Male; Molecular Sequence Data; Morphine; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Somatostatin; Spinal Cord | 1996 |
Mu- and delta-opioid receptor antagonists precipitate similar withdrawal phenomena in butorphanol and morphine dependence.
Topics: Animals; Butorphanol; Drug Evaluation, Preclinical; Injections, Intraventricular; Locus Coeruleus; Male; Morphine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Somatostatin; Substance Withdrawal Syndrome | 1996 |
Differential role of delta-opioid receptors in the development and expression of behavioral sensitization to cocaine.
Topics: Animals; Behavior, Animal; Cocaine; Male; Motor Activity; Naltrexone; Narcotic Antagonists; Narcotics; Nicotine; Nicotinic Agonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta | 1996 |
The influence of opioid antagonists on the discriminative stimulus effects of ethanol.
Topics: Animals; Discrimination, Psychological; Dose-Response Relationship, Drug; Ethanol; Male; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar | 1996 |
Naltrindole sensitive delta 2 opioid receptor mediates invertebrate immunocyte activation.
Topics: Animals; Bivalvia; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Humans; Immune System; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta | 1995 |
Effects of the delta opioid against BW373U86 in pigeons trained to discriminate fentanyl, bremazocine and water in a three-choice drug discrimination procedure.
Topics: Analgesics; Animals; Benzamides; Benzomorphans; Columbidae; Discrimination, Psychological; Female; Fentanyl; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Piperazines; Receptors, Opioid, delta | 1996 |
Comparison of cyclic delta-opioid peptides with non-peptide delta-agonist spiroindanyloxymorphone (SIOM) using the message-address concept: a molecular modeling study.
Topics: Drug Design; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ligands; Magnetic Resonance Spectroscopy; Models, Molecular; Naltrexone; Narcotic Antagonists; Oxymorphone; Peptides, Cyclic; Protein Binding; Protein Conformation; Receptors, Opioid, delta; Spiro Compounds; Structure-Activity Relationship | 1996 |
Effects of selective opioid receptor antagonists on morphine-induced changes in striatal and limbic dopamine metabolism.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Dopamine; Homovanillic Acid; Injections, Intraperitoneal; Injections, Intraventricular; Limbic System; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pain Threshold; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu | 1995 |
Antiallodynic effects of a CCKB antagonist in rats with nerve ligation injury: role of endogenous enkephalins.
Topics: Animals; Male; Naltrexone; Narcotic Antagonists; Pain; Peripheral Nervous System; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Thiorphan | 1996 |
Delta-Opioid receptor modulation of the release of substance P-like immunoreactivity in the dorsal horn of the rat following mechanical or thermal noxious stimulation.
Topics: Animals; Decerebrate State; Enkephalin, Methionine; Functional Laterality; Hindlimb; Hot Temperature; Male; Naltrexone; Narcotic Antagonists; Pain; Physical Stimulation; Rats; Rats, Wistar; Receptors, Opioid, delta; Spinal Cord; Substance P; Time Factors | 1996 |
Differential effects of delta- and mu-opioid receptor antagonists on the amphetamine-induced increase in extracellular dopamine in striatum and nucleus accumbens.
Topics: Amphetamine; Analysis of Variance; Animals; Dopamine; Dopamine Agents; Dose-Response Relationship, Drug; Extracellular Space; Male; Microdialysis; Naltrexone; Narcotic Antagonists; Neostriatum; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu | 1996 |
Opioid receptor-mediated control of acetylcholine release in human neocortex tissue.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetylcholine; Adolescent; Adult; Aged; Analgesics; Analysis of Variance; Baclofen; Cerebral Cortex; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; GABA Agonists; Humans; Male; Middle Aged; Muscimol; Naloxone; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid, delta; Tetrodotoxin | 1996 |
Moving from the orphanin FQ receptor to an opioid receptor using four point mutations.
Topics: Analgesics; Animals; Benzomorphans; Dynorphins; Models, Molecular; Naltrexone; Narcotic Antagonists; Nociceptin Receptor; Point Mutation; Rats; Receptors, Opioid | 1996 |
Application of the message-address concept to the docking of naltrexone and selective naltrexone-derived opioid antagonists into opioid receptor models.
Topics: Amino Acid Sequence; Animals; Binding Sites; Conserved Sequence; GTP-Binding Proteins; Models, Molecular; Models, Structural; Molecular Conformation; Molecular Sequence Data; Naltrexone; Narcotic Antagonists; Protein Conformation; Receptors, Opioid, delta; Receptors, Opioid, kappa | 1996 |
Further evidence for a peripheral component in the enhanced antinociceptive effect of systemic morphine in mononeuropathic rats: involvement of kappa-, but not delta-opioid receptors.
Topics: Analgesia; Animals; Constriction; Drug Interactions; Injections, Intravenous; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Sciatic Nerve; Vocalization, Animal | 1996 |
[Opiatergic mechanisms of antiarrhythmic effect of adaptation].
Topics: Adaptation, Physiological; Animals; Arrhythmias, Cardiac; Calcium Chloride; Disulfides; Endorphins; Enzyme Inhibitors; Epinephrine; Male; Naltrexone; Narcotic Antagonists; Neprilysin; Phenylalanine; Rats; Rats, Wistar; Receptors, Opioid | 1996 |
Different central opioid receptor subtype antagonists modify maltose dextrin and deprivation-induced water intake in sham feeding and sham drinking rats.
Topics: Animals; Dose-Response Relationship, Drug; Drinking; Eating; Enkephalin, Leucine-2-Alanine; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Polysaccharides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Water Deprivation | 1996 |
Potentiation of delta 9-tetrahydrocannabinol-induced analgesia by morphine in mice: involvement of mu- and kappa-opioid receptors.
Topics: Analgesia; Analgesics, Opioid; Animals; Binding Sites; Dronabinol; Drug Synergism; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Pain Measurement; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1996 |
Antinociception by intrathecal midazolam involves endogenous neurotransmitters acting at spinal cord delta opioid receptors.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Midazolam; Naltrexone; Narcotic Antagonists; Nociceptors; Pain Measurement; Pain Threshold; Rats; Receptors, Opioid; Receptors, Opioid, delta; Spinal Cord | 1996 |
Functional expression, activation and desensitization of opioid receptor-like receptor ORL1 in neuroblastoma x glioma NG108-15 hybrid cells.
Topics: Colforsin; Cyclic AMP; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glioma; GTP-Binding Proteins; Hybrid Cells; Naltrexone; Narcotic Antagonists; Neuroblastoma; Nociceptin; Nociceptin Receptor; Opioid Peptides; Pertussis Toxin; Receptors, Opioid; Receptors, Opioid, delta; Virulence Factors, Bordetella | 1997 |
Imaging of delta opioid receptors in human brain by N1'-([11C]methyl)naltrindole and PET.
Topics: Adult; Brain; Female; Humans; Image Processing, Computer-Assisted; Male; Naltrexone; Receptors, Opioid, delta; Tomography, Emission-Computed | 1996 |
Effects of mu-, delta- and kappa-opioid antagonists in atrial preparations from nonfailing and failing human hearts.
Topics: Adult; Aged; Depression, Chemical; Dose-Response Relationship, Drug; Female; Heart; Heart Atria; Heart Valve Diseases; Humans; In Vitro Techniques; Male; Middle Aged; Mitral Valve; Myocardial Contraction; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1997 |
Overexpression of delta-opioid receptors in recombinant baculovirus-infected Trichoplusia ni "High 5" insect cells.
Topics: Adenylyl Cyclases; Analgesics; Animals; Baculoviridae; Binding, Competitive; Blotting, Western; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Gene Expression; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Immunoblotting; Membrane Proteins; Mice; Naltrexone; Narcotic Antagonists; Ovary; Receptors, Opioid, delta; Recombinant Proteins; Spodoptera; Tritium; Viral Proteins | 1997 |
Acute and chronic effects of opioids on delta and mu receptor activation of G proteins in NG108-15 and SK-N-SH cell membranes.
Topics: Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Glioma; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Hybrid Cells; Membrane Proteins; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Neuroblastoma; Protein Binding; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Signal Transduction; Sulfur Radioisotopes; Time Factors | 1997 |
Opioid diketopiperazines: refinement of the delta opioid antagonist pharmacophore.
Topics: Diketopiperazines; Molecular Conformation; Monte Carlo Method; Naltrexone; Narcotic Antagonists; Narcotics; Oligopeptides; Piperazines; Receptors, Opioid, delta; Structure-Activity Relationship; Tetrahydroisoquinolines | 1997 |
Distinct components of morphine effects on cardiac myocytes are mediated by the kappa and delta opioid receptors.
Topics: Analgesics, Opioid; Animals; Animals, Newborn; Calcium; Cells, Cultured; Heart; Heart Ventricles; Morphine; Myocardial Contraction; Myocardium; Naltrexone; Narcotic Antagonists; Rats; Receptors, Opioid, delta; Receptors, Opioid, kappa | 1997 |
Neuropeptide FF in the rat spinal cord during carrageenan inflammation.
Topics: Animals; Carrageenan; Hot Temperature; Inflammation; Male; Morphine; Naltrexone; Narcotic Antagonists; Neurons; Neuropeptides; Oligopeptides; Pain; Rats; Rats, Sprague-Dawley; Spinal Cord | 1997 |
Relative efficacies of delta-opioid receptor agonists at the cloned human delta-opioid receptor.
Topics: Animals; Benzamides; CHO Cells; Cloning, Molecular; Cricetinae; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Naltrexone; Narcotic Antagonists; Piperazines; Quinolines; Receptors, Opioid, delta; Sulfur Radioisotopes | 1997 |
Differential effects of naltrindole on morphine-induced tolerance and physical dependence in rats.
Topics: Animals; Drug Tolerance; Female; Male; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Substance-Related Disorders | 1997 |
Involvement of spinal cord delta opiate receptors in the antinociception of gestation and its hormonal simulation.
Topics: Animals; Benzylidene Compounds; Female; Humans; Injections, Spinal; Male; Naltrexone; Narcotic Antagonists; Pain; Pregnancy; Pregnancy, Animal; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Sensory Thresholds; Sex Characteristics; Spinal Cord; Time Factors | 1997 |
Opioid modulation of attention-related responses: delta-receptors modulate habituation and conditioned bradycardia.
Topics: Animals; Attention; Bradycardia; Conditioning, Psychological; Female; Habituation, Psychophysiologic; Heart Rate; Male; Naltrexone; Narcotic Antagonists; Narcotics; Rabbits | 1997 |
Extraordinary potency of a novel delta opioid receptor agonist is due in part to increased efficacy.
Topics: Animals; Biological Assay; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Narcotic Antagonists; Peptides; Peptides, Cyclic; Receptors, Opioid, delta; Vas Deferens | 1997 |
In vivo binding of [125I]NH2-carfentanil to mu opioid receptors in mouse brain.
Topics: Animals; Autoradiography; Brain; Fentanyl; Injections, Intraperitoneal; Iodine Radioisotopes; Logistic Models; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Radioligand Assay; Receptors, Opioid, mu | 1994 |
Involvement of opioid mu 1 receptors in morphine-induced conditioned place preference in rats.
Topics: Analgesics, Opioid; Animals; Body Temperature; Catalepsy; Conditioning, Operant; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Rats; Rats, Wistar; Receptors, Opioid, mu | 1997 |
The role of delta-opioid receptors in the discriminative stimulus properties of a low dose of methamphetamine.
Topics: Animals; Benzylidene Compounds; Central Nervous System Stimulants; Discrimination, Psychological; Dose-Response Relationship, Drug; Male; Methamphetamine; Naltrexone; Quinolines; Rats; Rats, Inbred F344; Receptors, Opioid, delta | 1997 |
Ischemic preconditioning and morphine-induced cardioprotection involve the delta (delta)-opioid receptor in the intact rat heart.
Topics: Animals; Cardiovascular Agents; Heart; Ischemic Preconditioning, Myocardial; Male; Morphine; Myocardial Infarction; Myocardium; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid, delta; Thiopental | 1997 |
Brain and spinal cord distribution of biphalin: correlation with opioid receptor density and mechanism of CNS entry.
Topics: Analgesics; Animals; Binding, Competitive; Brain; Enkephalins; Iodine Radioisotopes; Kinetics; Models, Chemical; Naloxone; Naltrexone; Narcotic Antagonists; Organ Specificity; Peptides; Radioisotope Dilution Technique; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord; Tissue Distribution | 1997 |
Immunomodulatory responses to delta-opioid receptor ligands in human lymphocytes.
Topics: Analgesics, Opioid; Humans; Interferon-gamma; Leukocytes, Mononuclear; Ligands; Lymphocyte Activation; Naltrexone; Narcotic Antagonists; Oligopeptides; Phytohemagglutinins; Receptors, Opioid, delta; Thymidine | 1997 |
Food intake and food choice: the role of the endogenous opioid peptides in the marsupial Sminthopsis crassicaudata.
Topics: Animals; Diet; Eating; Endorphins; Energy Intake; Food Preferences; Male; Marsupialia; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1997 |
Prejunctional modulation by nociceptin of nerve-mediated inotropic responses in guinea-pig left atrium.
Topics: Animals; Atrial Function; Calcitonin Gene-Related Peptide; Capsaicin; Electric Stimulation; Guinea Pigs; Heart Atria; In Vitro Techniques; Male; Myocardial Contraction; Naloxone; Naltrexone; Neuromuscular Junction; Neurons, Afferent; Nociceptin; Opioid Peptides; Sensory Receptor Cells | 1997 |
Naltrindole, a selective delta-opioid receptor antagonist, potentiates the lethal effects of cocaine by a central mechanism of action.
Topics: Animals; Blood Pressure; Central Nervous System; Cisterna Magna; Cocaine; Drug Synergism; Heart Rate; Infusions, Intravenous; Injections; Male; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Seizures | 1997 |
Butorphanol-mediated antinociception in mice: partial agonist effects and mu receptor involvement.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Butorphanol; Male; Mice; Morphine; Naltrexone; Pyrrolidines; Receptors, Opioid, mu | 1997 |
Interleukin-6 is differently modulated by central opioid receptor subtypes.
Topics: Animals; Cerebral Ventricles; Humans; Injections, Intraperitoneal; Injections, Intraventricular; Interleukin-1; Interleukin-6; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Proteins | 1997 |
The possible role of protein phosphatase 2A in the sodium sensitivity of the receptor binding of opiate antagonists naloxone and naltrindole.
Topics: Animals; Corpus Striatum; Enzyme Activation; Enzyme Inhibitors; Male; Marine Toxins; Naloxone; Naltrexone; Narcotic Antagonists; Oxazoles; Phosphoprotein Phosphatases; Phosphorus Radioisotopes; Phosphorylase a; Protein Phosphatase 1; Protein Phosphatase 2; Rats; Rats, Wistar; Receptors, Opioid; Sensitivity and Specificity; Sodium Chloride; Substrate Specificity; Tritium | 1997 |
Anatomical distribution of mu, delta, and kappa opioid- and nociceptin/orphanin FQ-stimulated [35S]guanylyl-5'-O-(gamma-thio)-triphosphate binding in guinea pig brain.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Non-Narcotic; Animals; Autoradiography; Brain Chemistry; Cerebellum; Diencephalon; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Male; Medulla Oblongata; Mesencephalon; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptin; Opioid Peptides; Pons; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sulfur Radioisotopes; Telencephalon | 1997 |
Discovery of a novel class of substituted pyrrolooctahydroisoquinolines as potent and selective delta opioid agonists, based on an extension of the message-address concept.
Topics: Animals; Benzamides; Brain; Computer Simulation; Dose-Response Relationship, Drug; Drug Design; Enkephalin, Leucine-2-Alanine; Indoles; Isoquinolines; Ligands; Male; Mice; Models, Molecular; Naltrexone; Narcotic Antagonists; Nociceptors; Piperazines; Pyrroles; Quinolines; Receptors, Opioid, delta; Signal Transduction; Stereoisomerism; Vas Deferens | 1997 |
Conditioned immunomodulation: investigations of the role of endogenous activity at mu, kappa, and delta opioid receptor subtypes.
Topics: Animals; Avoidance Learning; Cell Division; Conditioning, Classical; Electroshock; Immune System; Killer Cells, Natural; Lipopolysaccharides; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Lew; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spleen | 1997 |
Naltrexone, naltrindole, and CTOP block cocaine-induced sensitization to seizures and death.
Topics: Animals; Cocaine-Related Disorders; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Seizures; Somatostatin | 1997 |
Antinociceptive effects of (+)-matrine in mice.
Topics: Abdomen; Alkaloids; Analgesics; Animals; Male; Matrines; Mice; Mice, Inbred ICR; Muscle Contraction; Naltrexone; Narcotic Antagonists; Pain Measurement; Quinolizines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tail | 1997 |
Mutagenesis of the mouse delta opioid receptor converts (-)-buprenorphine from a partial agonist to an antagonist.
Topics: Analgesics, Opioid; Animals; Buprenorphine; Cells, Cultured; Cyclic AMP; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Mice; Mutagenesis; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta | 1998 |
Characterization of opiate binding sites on the goldfish (Carassius auratus L.) pronephric leukocytes.
Topics: Animals; Binding Sites; Goldfish; Leukocytes; Morphinans; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Receptors, Opioid, mu | 1997 |
Hippocampal theta activity after systemic administration of a non-peptide delta-opioid agonist in freely-moving rats: relationship to D1 dopamine receptors.
Topics: Animals; Benzamides; Benzazepines; Dopamine Agonists; Dopamine Antagonists; Hippocampus; Locomotion; Naltrexone; Narcotic Antagonists; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Opioid, delta; Theta Rhythm | 1997 |
Opioid receptor-mediated inhibition of omega-conotoxin GVIA-sensitive calcium channel currents in rat intracardiac neurons.
Topics: Acetylcholine; Animals; Animals, Newborn; Anti-Arrhythmia Agents; Benzomorphans; Calcium; Calcium Channels; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Heart Conduction System; Ion Channel Gating; Ion Transport; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; omega-Conotoxin GVIA; Parasympathetic Nervous System; Patch-Clamp Techniques; Peptides; Pertussis Toxin; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Virulence Factors, Bordetella | 1998 |
Opioid inhibition of adenylyl cyclase in membranes from pertussis toxin-treated NG108-15 cells.
Topics: Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Animals; Catalysis; Cell Membrane; Enzyme Activation; GTP Phosphohydrolases; GTP-Binding Proteins; Guanine Nucleotides; Guanosine 5'-O-(3-Thiotriphosphate); Hydrolysis; Kinetics; Mice; Naltrexone; Narcotics; Neuroblastoma; Pertussis Toxin; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1998 |
Differential involvement of opioid receptors in intrathecal butorphanol-induced analgesia: compared to morphine.
Topics: Analgesics, Opioid; Animals; Butorphanol; Dose-Response Relationship, Drug; Injections, Spinal; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid | 1998 |
Morphine-6-glucuronide-induced locomotor stimulation in mice: role of opioid receptors.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred C57BL; Morphine; Morphine Derivatives; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid | 1998 |
Brain opioid receptor binding of [3H]CTOP and [3H]naltrindole in alcohol-preferring AA and alcohol-avoiding ANA rats.
Topics: Alcohol Drinking; Amygdala; Animals; Autoradiography; Brain; Corpus Striatum; Food Preferences; Hippocampus; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Mutant Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Somatostatin; Substantia Nigra; Tritium | 1998 |
Evidence that spinal endogenous opioidergic systems control the expression of chronic pain-related behaviors in spinally injured rats.
Topics: Animals; Behavior, Animal; Chronic Disease; Cold Temperature; Female; Hyperalgesia; Injections, Spinal; Naltrexone; Narcotic Antagonists; Pain; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Self Mutilation; Somatostatin; Spinal Cord Injuries; Stress, Mechanical | 1998 |
[125I-Tyr1]biphalin binding to opioid receptors of rat brain and NG108-15 cell membranes.
Topics: Animals; Brain; Cell Line; Cell Membrane; Enkephalins; Iodine Radioisotopes; Morphine; Naltrexone; Narcotic Antagonists; Oligopeptides; Radioligand Assay; Rats; Receptors, Opioid | 1998 |
Differential modulation of mu- and delta-opioid antinociception by neuropeptide FF receptors in young mice.
Topics: Age Factors; Analgesics, Opioid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Mice; Mice, Inbred Strains; Morphine; Naltrexone; Narcotic Antagonists; Neuropeptides; Nociceptors; Oligopeptides; Receptors, Neuropeptide; Receptors, Opioid, delta; Receptors, Opioid, mu | 1997 |
Identification of opioid receptor subtypes in antinociceptive actions of supraspinally-administered mitragynine in mice.
Topics: Analgesics; Animals; Drug Synergism; Injections, Intraventricular; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Pain Measurement; Receptors, Opioid; Receptors, Opioid, mu; Secologanin Tryptamine Alkaloids | 1998 |
A comparison of the effects of the opioid antagonists naltrexone, naltrindole, and beta-funaltrexamine on ethanol consumption in the rat.
Topics: Alcohol Drinking; Animals; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu | 1998 |
The effects of aging on mu and delta opioid receptors in the spinal cord of Fischer-344 rats.
Topics: Aging; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Naltrexone; Narcotic Antagonists; Radioligand Assay; Rats; Rats, Inbred F344; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord | 1998 |
Training dose and session time as contextual determinants of heroin self-administration in rats.
Topics: Animals; Dose-Response Relationship, Drug; Heroin; Male; Naltrexone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Rats; Rats, Inbred F344; Self Administration; Time Factors | 1998 |
Opioids modulate the calcitonin gene-related peptide8-37-mediated hindpaw withdrawal latency increase in thermally injured rats.
Topics: Animals; Brain Chemistry; Burns; Calcitonin Gene-Related Peptide; Hindlimb; Injections, Spinal; Male; Mitogens; Naltrexone; Narcotic Antagonists; Nociceptors; Pain; Peptide Fragments; Pressure; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reflex | 1998 |
14-Desoxy analogues of naltrindole and 7-spiroindanyloxymorphone: the role of the 14-hydroxy group at delta opioid receptors.
Topics: Animals; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Muscle Contraction; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Oxymorphone; Receptors, Opioid, delta; Spiro Compounds; Vas Deferens | 1998 |
Synthesis, opioid receptor binding, and bioassay of naltrindole analogues substituted in the indolic benzene moiety.
Topics: Animals; Brain; Guinea Pigs; Ileum; Indoles; Ligands; Male; Mice; Morphinans; Muscle Contraction; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship; Vas Deferens | 1998 |
The role of subtypes of the opioid receptor in the anxiolytic action of chlordiazepoxide.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Chlordiazepoxide; Male; Mice; Naltrexone; Narcotic Antagonists; Receptors, Opioid | 1998 |
NTI4F: a non-peptide fluorescent probe selective for functional delta opioid receptors.
Topics: Animals; Bridged-Ring Compounds; Cell Line; Dogs; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Fluorescent Dyes; Imides; Microscopy, Confocal; Microscopy, Fluorescence; Morphine; Naltrexone; Receptors, Opioid, delta; Transfection | 1998 |
Synthesis of 7-arylmorphinans. Probing the "address" requirements for selectivity at opioid delta receptors.
Topics: Animals; Electric Stimulation; Guinea Pigs; Ileum; In Vitro Techniques; Ligands; Male; Mice; Models, Molecular; Molecular Conformation; Morphinans; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Oxymorphone; Pain Measurement; Receptors, Opioid, delta; Spiro Compounds; Vas Deferens | 1998 |
The involvement of the opioidergic system in the antinociceptive mechanism of action of antidepressant compounds.
Topics: Abdominal Muscles; Acetic Acid; Amitriptyline; Analgesics; Animals; Antidepressive Agents; Cyclobutanes; Dothiepin; Male; Maprotiline; Mice; Muscle Contraction; Naloxone; Naltrexone; Narcotic Antagonists; Neprilysin; Neurotransmitter Uptake Inhibitors; Opioid Peptides; Pain Measurement; Paroxetine; Protease Inhibitors; Receptors, Opioid; Selective Serotonin Reuptake Inhibitors; Thiorphan | 1998 |
Affinity profiles of novel delta-receptor selective benzofuran derivatives of non-peptide opioids.
Topics: Animals; Benzeneacetamides; Benzofurans; Binding, Competitive; Brain; Cell Membrane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Naloxone; Naltrexone; Oligopeptides; Oxycodone; Oxymorphone; Pyrrolidines; Radioligand Assay; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Tritium | 1998 |
Involvement of delta-opioid receptors in the effects induced by endogenous enkephalins on learned helplessness model.
Topics: Analgesics; Animals; Behavior, Animal; Disulfides; Drug Interactions; Enkephalins; Helplessness, Learned; Male; Naltrexone; Narcotic Antagonists; Oligopeptides; Phenylalanine; Rats; Rats, Wistar; Receptors, Opioid, delta | 1998 |
The delta1-opioid receptor antagonist, 7-(benzospiroindanyl)naltrexone [correction of 7-benzylspiroindanylnaltrexone], prolongs renal allograft survival in a rat model.
Topics: Animals; Dose-Response Relationship, Drug; Graft Survival; Kidney Transplantation; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred BUF; Rats, Inbred Lew; Receptors, Opioid, delta; Spiro Compounds | 1998 |
Involvement of mu- and delta-opioid receptors in the ethanol-associated place preference in rats exposed to foot shock stress.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Ethanol; Exploratory Behavior; Foot; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Morphine; Naloxone; Naltrexone; Narcotics; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu | 1998 |
Effects of preweanling chronic naltrindole administration on stress-induced antinociceptive responses in rats.
Topics: Aging; Alfentanil; Analgesics, Opioid; Animals; Animals, Newborn; Drug Administration Schedule; Female; Naltrexone; Narcotic Antagonists; Pain; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Stress, Psychological; Swimming | 1998 |
Delta-opioid suppression of human immunodeficiency virus-1 expression in T cells (Jurkat).
Topics: Benzamides; HIV-1; Humans; Jurkat Cells; Naltrexone; Oligopeptides; Piperazines; Receptors, Opioid, delta; T-Lymphocytes | 1998 |
Renal excretory responses produced by the delta opioid agonist, BW373U86, in conscious rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzamides; Denervation; Infusions, Intravenous; Kidney; Male; Naltrexone; Oligopeptides; Opioid Peptides; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta | 1998 |
Contribution of the opioid system to alcohol aversion and alcohol drinking behavior.
Topics: Alcohol Drinking; Animals; Conditioning, Psychological; Dose-Response Relationship, Drug; Endorphins; Enkephalins; Ethanol; Female; Naltrexone; Rats; Rats, Wistar; Receptors, Opioid, delta | 1998 |
Intracerebroventricular injection of mu- and delta-opiate receptor antagonists block 60 Hz magnetic field-induced decreases in cholinergic activity in the frontal cortex and hippocampus of the rat.
Topics: Animals; Cerebral Ventricles; Choline; Frontal Lobe; Hippocampus; Injections, Intraventricular; Magnetics; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Sodium | 1998 |
The effect of pentylenetetrazol kindling on synaptic mechanisms of interacting glutamatergic and opioid system in the hippocampus of rats.
Topics: Animals; Convulsants; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hippocampus; In Vitro Techniques; Kindling, Neurologic; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pentylenetetrazole; Rats; Rats, Wistar; Receptors, Glutamate; Receptors, Opioid; Seizures; Synapses | 1998 |
Opioid involvement in behavior modifications of mice infected with the parasitic nematode, Nippostrongylus brasiliensis.
Topics: Animals; Behavior, Animal; Injections, Intraperitoneal; Male; Mice; Mice, Inbred ICR; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Nippostrongylus; Reaction Time; Receptors, Opioid; Receptors, Opioid, mu; Receptors, sigma; Strongylida Infections | 1998 |
5-HT4 receptor agonists and delta-opioid receptor antagonists act synergistically to stimulate colonic propulsion.
Topics: Animals; Benzeneacetamides; Colon; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Guinea Pigs; In Vitro Techniques; Male; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Peptide Fragments; Peristalsis; Pyrrolidines; Receptors, Opioid, delta; Receptors, Serotonin; Receptors, Serotonin, 5-HT4; Serotonin Receptor Agonists; Somatostatin | 1998 |
Ameliorative effects of tachykinins on scopolamine-induced impairment of spontaneous alternation performance in mice.
Topics: Animals; Male; Mice; Muscarinic Antagonists; Naloxone; Naltrexone; Narcotic Antagonists; Neurokinin A; Peptide Fragments; Psychomotor Performance; Scopolamine; Substance P; Tachykinins | 1998 |
Time window for the contribution of the delta-opioid receptor to cardioprotection by ischemic preconditioning in the rat heart.
Topics: Animals; Heart; Ischemic Preconditioning, Myocardial; Male; Myocardial Infarction; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Time Factors | 1998 |
Dopamine-dependent behavioural stimulation by non-peptide delta opioids BW373U86 and SNC 80: 2. Place-preference and brain microdialysis studies in rats.
Topics: Animals; Behavior, Animal; Benzamides; Benzazepines; Brain Chemistry; Caudate Nucleus; Conditioning, Operant; Dopamine; Dopamine Antagonists; Extracellular Space; Male; Microdialysis; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Piperazines; Rats; Rats, Sprague-Dawley | 1998 |
Effect of naltrexone and its derivatives, nalmefene and naltrindole, on conditioned anticipatory behaviour and saccharin intake in rats.
Topics: Animals; Conditioning, Operant; Cues; Dose-Response Relationship, Drug; Drinking Behavior; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Saccharin; Sweetening Agents; Taste | 1997 |
Intrathecal administration of p-hydroxymercuribenzoate or phosphoramidon/bestatin-combined induces antinociceptive effects through different opioid mechanisms.
Topics: Animals; Capsaicin; Dose-Response Relationship, Drug; Drug Combinations; Glycopeptides; Hindlimb; Hydroxymercuribenzoates; Injections, Spinal; Leucine; Male; Mice; Mice, Inbred Strains; Naltrexone; Narcotic Antagonists; Pain; Protease Inhibitors; Receptors, Opioid; Time Factors | 1998 |
Weaning-induced development of delta-opioid receptors in rat brain: differential effects of guanine nucleotides and sodium upon ligand-receptor recognition.
Topics: Animals; Brain; Guanylyl Imidodiphosphate; In Vitro Techniques; Ligands; Naltrexone; Oligopeptides; Rats; Rats, Wistar; Receptors, Opioid, delta; Sodium; Weaning | 1998 |
Delta-opioid ligands reverse alfentanil-induced respiratory depression but not antinociception.
Topics: Alfentanil; Analgesics, Opioid; Animals; Benzamides; Hypercapnia; Ligands; Male; Naltrexone; Narcotic Antagonists; Narcotics; Oligopeptides; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Respiration; Respiratory Insufficiency; Somatostatin | 1998 |
Synthesis and biological activity of 3-substituted 3-desoxynaltrindole derivatives.
Topics: Animals; Benzeneacetamides; Binding, Competitive; Brain; Cell Membrane; Drug Design; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Molecular Structure; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rats; Receptors, Opioid, delta; Structure-Activity Relationship | 1998 |
Endomorphin-1 and endomorphin-2 activate mu-opioid receptors in myenteric neurons of the guinea-pig small intestine.
Topics: Acetylcholine; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Electric Stimulation; Female; Guinea Pigs; Ileum; Intestine, Small; Male; Myenteric Plexus; Naltrexone; Oligopeptides; Receptors, Opioid, mu; Regression Analysis; Somatostatin | 1998 |
Heroin antinociception changed from mu to delta receptor in streptozotocin-treated mice.
Topics: Analgesics, Opioid; Animals; Anti-Bacterial Agents; Benzylidene Compounds; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Heroin; Injections, Intraventricular; Male; Mice; Morphine; Morphine Derivatives; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Pain; Receptors, Opioid, delta; Receptors, Opioid, mu; Streptozocin; Time Factors | 1998 |
Effects of peptidase inhibitors on the enkephalin-induced anti-nociception in rats.
Topics: Animals; Anti-Bacterial Agents; Area Under Curve; Captopril; Dose-Response Relationship, Drug; Drug Therapy, Combination; Enkephalin, Methionine; Glycopeptides; Injections, Intraventricular; Injections, Subcutaneous; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Pain; Pain Measurement; Peptides; Protease Inhibitors; Rats; Rats, Wistar | 1998 |
Phosphorylation of adenylyl cyclase VI upon chronic delta-opioid receptor stimulation.
Topics: Adenylyl Cyclases; Animals; Benzamides; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Naltrexone; Narcotic Antagonists; Phosphorylation; Piperazines; Receptors, Opioid, delta; Time Factors | 1999 |
Effects of neonatal naltrindole treatment on antinociceptive and behavioral responses to mu and kappa agonists in rats.
Topics: Alfentanil; Animals; Animals, Newborn; Benzofurans; Male; Naltrexone; Narcotic Antagonists; Narcotics; Pain Measurement; Psychomotor Performance; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1999 |
Naltrindole administration during the preweanling period and manipulation affect adrenocortical reactivity in young rats.
Topics: Adrenal Cortex; Animals; Animals, Suckling; Corticosterone; Female; Handling, Psychological; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid, delta; Sex Characteristics; Stress, Physiological; Swimming; Temperature; Water | 1999 |
Stereoselective mu- and delta-opioid receptor-related antinociception and binding with (+)-thebaine.
Topics: Analgesics; Animals; Binding, Competitive; Cells, Cultured; Epilepsy; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Pain Measurement; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Stereoisomerism; Thebaine | 1999 |
The involvement of opioidergic and noradrenergic mechanisms in nefopam antinociception.
Topics: Abdominal Pain; Acetic Acid; Adrenergic alpha-Antagonists; Analgesics; Analgesics, Non-Narcotic; Animals; Clonidine; Dose-Response Relationship, Drug; Drug Interactions; Idazoxan; Injections, Intraventricular; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Nefopam; Pain Measurement; Receptors, Adrenergic; Receptors, Opioid | 1999 |
Chronic naltrindole administration does not modify the inhibitory effect of morphine on vocalization responses in the tail electric stimulation test in rats.
Topics: Albinism; Animals; Electric Stimulation; Male; Morphine; Movement; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Tail; Vocalization, Animal | 1999 |
Role of the kappa-opioid system in the attenuation of the morphine-induced place preference under chronic pain.
Topics: Animals; Chronic Disease; Conditioning, Psychological; Formaldehyde; Hindlimb; Inflammation; Male; Morphine; Naltrexone; Pain; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Reward; Time Factors | 1999 |
Opioid peptide pharmacology and immunocytochemistry in an animal model of self-sustaining status epilepticus.
Topics: Action Potentials; Analgesics; Analgesics, Opioid; Animals; Disease Models, Animal; Dynorphins; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Immunohistochemistry; Male; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Opioid Peptides; Peptide Fragments; Perforant Pathway; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Status Epilepticus | 1999 |
Effects of opioid receptor antagonists on the effects of i.v. morphine on carrageenin evoked c-Fos expression in the superficial dorsal horn of the rat spinal cord.
Topics: Analgesics, Opioid; Animals; Carrageenan; Hindlimb; Inflammation; Injections, Intravenous; Male; Morphine; Naltrexone; Narcotic Antagonists; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin; Spinal Cord | 1999 |
[Opiatergic mechanisms of cardioprotective and anti-arrhythmic effects of adaptation].
Topics: Adaptation, Physiological; Animals; Arrhythmias, Cardiac; Enkephalin, Leucine; Epinephrine; Heart; Hypoxia; Immobilization; Male; Naltrexone; Narcotic Antagonists; Plant Extracts; Rats; Rats, Wistar | 1999 |
Spinal administration of selective opioid antagonists in amphibians: evidence for an opioid unireceptor.
Topics: Acetic Acid; Analgesics; Animals; Benzofurans; Female; Injections, Spinal; Male; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain Measurement; Pyrrolidines; Rana pipiens; Receptors, Opioid; Time Factors | 1999 |
Different roles of mu-, delta- and kappa-opioid receptors in ethanol-associated place preference in rats exposed to conditioned fear stress.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Behavior, Animal; Central Nervous System Depressants; Conditioning, Psychological; Ethanol; Fear; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stress, Psychological | 1999 |
[A molecular mechanism for supersensitization of adenylyl cyclase system in cloned opioid receptor-transfected cells following sustained opioid treatment].
Topics: Adenylyl Cyclases; Analgesics; Animals; Atropine; Benzeneacetamides; Carbachol; CHO Cells; Clone Cells; Cricetinae; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP Phosphohydrolases; Morphine; Muscarinic Agonists; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Transfection | 1998 |
Spinal blockade of opioid receptors prevents the analgesia produced by TENS in arthritic rats.
Topics: Animals; Arthritis; Behavior, Animal; Carrageenan; Injections, Intra-Articular; Kaolin; Male; Microdialysis; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord; Transcutaneous Electric Nerve Stimulation | 1999 |
delta Opioid affinity and selectivity of 4-hydroxy-3-methoxyindolomorphinan analogues related to naltrindole.
Topics: Animals; Binding, Competitive; Brain; Guanosine 5'-O-(3-Thiotriphosphate); Ileum; In Vitro Techniques; Indoles; Ligands; Male; Mice; Mice, Inbred ICR; Muscle Contraction; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Rabbits; Receptors, Opioid, delta; Vas Deferens | 1999 |
Analgesia-producing mechanism of processed Aconiti tuber: role of dynorphin, an endogenous kappa-opioid ligand, in the rodent spinal cord.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Administration, Topical; Analgesics; Animals; Arcuate Nucleus of Hypothalamus; Cold Temperature; Dexamethasone; Dopamine Antagonists; Drugs, Chinese Herbal; Dynorphins; Glucocorticoids; Hypothalamus; Immune Sera; Ligands; Male; Mice; Naltrexone; Narcotic Antagonists; Nociceptors; Pain; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Salicylamides; Spinal Cord; Sulpiride | 1999 |
The effects of intravenous naltrindole and naltrindole 5'-isothiocyanate on sufentanil-induced respiratory depression and antinociception in rats.
Topics: Analgesics, Opioid; Animals; Depression, Chemical; Hydrogen-Ion Concentration; Hypercapnia; Hypoxia; Isothiocyanates; Male; Naltrexone; Narcotic Antagonists; Pain Measurement; Rats; Rats, Wistar; Reaction Time; Receptors, Opioid, mu; Respiration; Sufentanil | 1999 |
Constitutive activation of the delta opioid receptor by mutations in transmembrane domains III and VII.
Topics: Amino Acid Substitution; Animals; Cell Membrane; COS Cells; Enkephalin, Leucine-2-Alanine; Guanosine 5'-O-(3-Thiotriphosphate); Ligands; Mice; Models, Molecular; Mutagenesis, Site-Directed; Naltrexone; Narcotic Antagonists; Protein Structure, Secondary; Receptors, Opioid, delta; Structure-Activity Relationship | 1999 |
Peripheral stimulation of CCK-B receptors by BC264 induces a hyperexploration, dependent on the delta opioid system in the nucleus accumbens of rat.
Topics: Animals; Cholecystokinin; Exploratory Behavior; Gastric Acid; Male; Microdialysis; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Peptide Fragments; Peripheral Nervous System; Rats; Rats, Wistar; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Receptors, Opioid, delta | 1999 |
Discriminative stimulus effects of the nonpeptidic delta-opioid agonist SNC80 in rhesus monkeys.
Topics: Analgesics, Opioid; Animals; Azocines; Benzamides; Discrimination Learning; Dose-Response Relationship, Drug; Female; Macaca mulatta; Male; Naltrexone; Narcotic Antagonists; Piperazines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stereoisomerism | 1999 |
Spinal effect of a neuropeptide FF analogue on hyperalgesia and morphine-induced analgesia in mononeuropathic and diabetic rats.
Topics: Analgesia; Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Diabetes Mellitus, Experimental; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Hyperalgesia; Injections, Spinal; Male; Morphine; Naltrexone; Narcotic Antagonists; Nervous System Diseases; Oligopeptides; Pain; Rats; Rats, Sprague-Dawley; Somatostatin; Time Factors; Vocalization, Animal | 1999 |
Quantification of delta-opioid receptors in human brain with N1'-([11C]methyl) naltrindole and positron emission tomography.
Topics: Adult; Brain; Female; Humans; Male; Naltrexone; Narcotic Antagonists; Radiography; Receptors, Opioid, delta; Tomography, Emission-Computed | 1999 |
Involvement of delta-opioid receptors in pentylenetetrazol kindling development and kindling-related processes in rats.
Topics: Animals; Convulsants; Drug Interactions; Glutamic Acid; Injections, Intraventricular; Kindling, Neurologic; Learning Disabilities; Male; Naltrexone; Narcotic Antagonists; Pentylenetetrazole; Rats; Rats, Wistar; Receptors, Opioid, delta; Seizures; Time Factors | 1999 |
Antinociceptive properties of FR140423 mediated through spinal delta-, but not mu- and kappa-, opioid receptors.
Topics: Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Binding, Competitive; Diarrhea; Injections, Intraventricular; Injections, Spinal; Male; Membranes; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Pyrazoles; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord; Sulfoxides | 1999 |
Use of selective antagonists and antisense oligonucleotides to evaluate the mechanisms of BUBU antinociception.
Topics: Analgesics; Animals; Male; Mice; Morphinans; Naltrexone; Narcotic Antagonists; Oligonucleotides, Antisense; Oligopeptides; Pain Measurement; Receptors, Opioid, delta; Receptors, Opioid, mu | 1999 |
Preweanling naltrindole administration differentially affects clonidine induced antinociception and plasma adrenaline levels in male and female neonatal rats.
Topics: Adrenergic alpha-Agonists; Analgesics; Animals; Animals, Newborn; Clonidine; Dose-Response Relationship, Drug; Epinephrine; Female; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid, delta; Sex Characteristics | 1999 |
Hypoalgesia elicited by a conditioned stimulus is blocked by a mu, but not a delta or a kappa, opioid antagonist injected into the rostral ventromedial medulla.
Topics: Animals; Conditioning, Psychological; Male; Medulla Oblongata; Naltrexone; Narcotic Antagonists; Pain Measurement; Peptide Fragments; Peptides; Rats; Rats, Long-Evans; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin | 1999 |
Identification of the G-protein-coupled ORL1 receptor in the mouse spinal cord by [35S]-GTPgammaS binding and immunohistochemistry.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Atropine; Autoradiography; Baclofen; Binding, Competitive; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Haloperidol; Immunohistochemistry; In Vitro Techniques; Male; Membranes; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Nociceptin; Nociceptin Receptor; Opioid Peptides; Peptide Fragments; Propranolol; Receptors, Opioid; Somatostatin; Spinal Cord; Sulfur Radioisotopes; Yohimbine | 1999 |
Neonatal naltrindole and handling differently affect morphine antinociception in male and female rats.
Topics: Analgesics; Animals; Female; Handling, Psychological; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Rats; Rats, Wistar; Sex Characteristics; Stress, Physiological | 1999 |
Characterization of [125I]AR-M100613, a high-affinity radioligand for delta opioid receptors.
Topics: Animals; Brain; Iodine Radioisotopes; Kinetics; Ligands; Male; Naltrexone; Oligopeptides; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta | 1999 |
Delta opioid binding selectivity of 3-ether analogs of naltrindole.
Topics: Naltrexone; Narcotic Antagonists; Protein Binding; Receptors, Opioid, delta | 1999 |
Delta-opioid and 5-HT3 receptor antagonist effects on ethanol reward and discrimination in C57BL/6 mice.
Topics: Animals; Conditioning, Operant; Discrimination Learning; Dose-Response Relationship, Drug; Ethanol; Female; Male; Mice; Mice, Inbred C57BL; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Reinforcement, Psychology; Reward; Serotonin Antagonists; Tropanes | 2000 |
Enhanced delta-opioid receptor-mediated antinociception in mu-opioid receptor-deficient mice.
Topics: Analgesia; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Hyperalgesia; Mice; Mice, Inbred C57BL; Mice, Knockout; Naltrexone; Receptors, Opioid, delta; Receptors, Opioid, mu | 2000 |
Differential down-regulation of the human delta-opioid receptor by SNC80 and [D-Pen(2),D-Pen(5)]enkephalin.
Topics: Benzamides; Down-Regulation; Enkephalin, D-Penicillamine (2,5)-; Humans; Naltrexone; Piperazines; Receptors, Opioid, delta | 2000 |
Selective mu and delta, but not kappa, opiate receptor antagonists inhibit the habituation of novelty-induced hypoalgesia in the rat.
Topics: Animals; Dose-Response Relationship, Drug; Habituation, Psychophysiologic; Male; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Rats; Rats, Wistar; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin | 2000 |
8-Aminocyclazocine analogues: synthesis and structure-activity relationships.
Topics: Analgesics; Animals; Benzeneacetamides; Binding, Competitive; Brain; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Guinea Pigs; Molecular Structure; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Stereoisomerism; Structure-Activity Relationship | 2000 |
Acute delta-opioid receptor activation induces CREB phosphorylation in NG108-15 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Analgesics, Opioid; Blotting, Western; Calmodulin; Cell Line; Cyclic AMP Response Element-Binding Protein; Enkephalin, D-Penicillamine (2,5)-; Enzyme Inhibitors; Humans; Isoquinolines; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Phosphorylation; Protein Kinase C; Protein Synthesis Inhibitors; Receptors, Opioid, delta; Time Factors | 2000 |
Postnatal naltrindole treatments induce behavioural modifications in preweanling rats.
Topics: Age Factors; Analgesics; Animals; Animals, Newborn; Behavior, Animal; Male; Motor Activity; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Reaction Time; Receptors, Opioid, delta; Weaning | 2000 |
Enhancement of natural immunity seen after voluntary exercise in rats. Role of central opioid receptors.
Topics: Animals; Immunity, Innate; Injections, Intraventricular; Naltrexone; Narcotic Antagonists; Physical Conditioning, Animal; Rats; Receptors, Opioid | 2000 |
Delta opioid receptors regulate calcium-dependent, amphetamine-evoked glutamate levels in the rat striatum: an in vivo microdialysis study.
Topics: Amphetamine; Animals; Calcium; Corpus Striatum; Dopamine Agents; Dopamine Antagonists; Glutamic Acid; Male; Microdialysis; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid, delta | 2000 |
Characterization of delta-opioid receptors and effect of enkephalins on IRD 98 rat epithelial intestinal cell line.
Topics: Analgesics, Opioid; Animals; Binding, Competitive; Cell Line; Cholera Toxin; Cyclic AMP; Dextrorphan; Enkephalin, Leucine-2-Alanine; Enkephalins; Epithelial Cells; Excitatory Amino Acid Antagonists; Fetus; Intestinal Secretions; Intestines; Kinetics; Levorphanol; Naltrexone; Narcotic Antagonists; Neprilysin; Protease Inhibitors; Rats; Receptors, Opioid, delta; Stereoisomerism; Thiorphan; Tritium | 2000 |
Inhibitory effect of intracerebroventricularly-administered [D-Arg(2), beta-Ala(4)]-dermorphin (1-4) on gastrointestinal transit.
Topics: Analgesics; Animals; Charcoal; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Female; Gastrointestinal Transit; Injections, Intraventricular; Mice; Mice, Inbred Strains; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides | 2000 |
Functional evidence that gastroprotection can be induced by activation of central alpha(2B)-adrenoceptor subtypes in the rat.
Topics: Adrenergic alpha-Agonists; Animals; Brain; Clonidine; Enkephalin, Leucine-2-Alanine; Gastric Mucosa; Injections, Intraventricular; Male; Naloxone; Naltrexone; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2 | 2000 |
Mice deficient for delta- and mu-opioid receptors exhibit opposing alterations of emotional responses.
Topics: Animals; Anxiety; Binding Sites; Darkness; Depression; Electroshock; Female; Gene Deletion; Light; Male; Mice; Mice, Knockout; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Pain Threshold; Phenotype; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sex Characteristics; Swimming | 2000 |
The effects of highly selective opioid receptor antagonists on the release of arginine vasotocin induced by hyperosmotic stimulation and angiotensin II injection.
Topics: Angiotensin II; Animals; Chickens; Male; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Saline Solution, Hypertonic; Vasotocin | 2000 |
Selective opioid receptor agonist and antagonist displacement of [3H]naloxone binding in amphibian brain.
Topics: Animals; Binding, Competitive; Brain; Dose-Response Relationship, Drug; Kinetics; Naloxone; Naltrexone; Narcotic Antagonists; Radioligand Assay; Rana pipiens; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tritium | 2000 |
Stress-induced analgesia in mu-opioid receptor knockout mice reveals normal function of the delta-opioid receptor system.
Topics: Analgesia; Animals; Cold Temperature; Mice; Mice, Knockout; Naltrexone; Narcotic Antagonists; Pain Measurement; Reaction Time; Receptors, Opioid, delta; Receptors, Opioid, mu; Stress, Physiological; Swimming; Time Factors | 2000 |
Altered opioid-mediated control of the spinal release of dynorphin and met-enkephalin in polyarthritic rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia; Animals; Arthritis; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Iodine Radioisotopes; Ligands; Male; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 2000 |
Potent and selective indolomorphinan antagonists of the kappa-opioid receptor.
Topics: Cell Line; Guanidines; Humans; Indoles; Models, Molecular; Morphinans; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Receptors, Opioid, kappa; Structure-Activity Relationship; Transfection | 2000 |
Involvement of central opioid systems in human interferon-alpha induced immobility in the mouse forced swimming test.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Interferon-alpha; Interferon-beta; Interferon-gamma; Male; Mice; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Swimming; Time Factors | 2000 |
Antinociceptive effects of Nigella sativa oil and its major component, thymoquinone, in mice.
Topics: Analgesics, Non-Narcotic; Animals; Benzoquinones; Dose-Response Relationship, Drug; Drug Tolerance; Injections, Intraventricular; Male; Mice; Motor Activity; Naloxone; Naltrexone; Plant Oils; Plants, Medicinal | 2000 |
Differential involvement of opioid receptors in stress-induced antinociception caused by repeated exposure to forced walking stress in mice.
Topics: Animals; Formaldehyde; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Receptors, Opioid; Stress, Physiological; Walking | 2000 |
BU48: a novel buprenorphine analog that exhibits delta-opioid-mediated convulsions but not delta-opioid-mediated antinociception in mice.
Topics: Analgesics, Opioid; Animals; Benzamides; Brain; Buprenorphine; Convulsants; Electric Stimulation; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Muscle Contraction; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Pain Measurement; Piperazines; Radioligand Assay; Rats; Receptors, Opioid, delta; Receptors, Opioid, kappa; Seizures; Vas Deferens | 2000 |
The effects of delta agonists on locomotor activity in habituated and non-habituated rats.
Topics: Animals; Benzamides; Dose-Response Relationship, Drug; Drug Tolerance; Male; Motor Activity; Naltrexone; Oligopeptides; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta | 2000 |
Selectivity of mu-opioid receptor determined by interfacial residues near third extracellular loop.
Topics: Amino Acid Substitution; Animals; Benzamides; Benzomorphans; Binding Sites; Binding, Competitive; COS Cells; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Fentanyl; Guanosine 5'-O-(3-Thiotriphosphate); Ligands; Morphine; Mutation; Naloxone; Naltrexone; Narcotic Antagonists; Peptides; Piperazines; Protein Conformation; Radioligand Assay; Rats; Receptors, Opioid, mu; Signal Transduction; Sulfur Radioisotopes | 2000 |
Assessment of SNC 80 and naltrindole within a conditioned taste aversion design.
Topics: Animals; Avoidance Learning; Benzamides; Conditioning, Operant; Dose-Response Relationship, Drug; Female; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Piperazines; Rats; Rats, Long-Evans; Receptors, Opioid, delta; Saccharin; Sweetening Agents; Taste | 2000 |
Morphine discriminative control is mediated by the mu opioid receptor: assessment of delta opioid substitution and antagonism.
Topics: Animals; Benzamides; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Female; Generalization, Response; Methadone; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Piperazines; Rats; Rats, Long-Evans; Receptors, Opioid, delta; Receptors, Opioid, mu | 2000 |
Modulation of humoral immune responses in the rat by centrally applied Met-Enk and opioid receptor antagonists: functional interactions of brain OP1, OP2 and OP3 receptors.
Topics: Adjuvants, Immunologic; Animals; Cells, Cultured; Enkephalin, Leucine; Enkephalin, Methionine; Hemolytic Plaque Technique; Immunoglobulins; Immunosuppressive Agents; Injections, Intraventricular; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2000 |
Synthesis and antinociceptive activity of pyrrolidinylnaphthalenes.
Topics: Analgesics; Animals; Drug Design; Male; Mice; Molecular Structure; Motor Activity; Naloxone; Naltrexone; Naphthalenes; Narcotic Antagonists; Pyrrolidines; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship | 2000 |
Inverse agonism by Dmt-Tic analogues and HS 378, a naltrindole analogue.
Topics: Benzamides; Benzeneacetamides; Binding, Competitive; Cell Line; Cell Membrane; Dipeptides; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Isoquinolines; Naltrexone; Narcotic Antagonists; Piperazines; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sulfur Radioisotopes; Tetrahydroisoquinolines | 2000 |
Plasmon resonance studies of agonist/antagonist binding to the human delta-opioid receptor: new structural insights into receptor-ligand interactions.
Topics: Biophysical Phenomena; Biophysics; Enkephalin, D-Penicillamine (2,5)-; Humans; In Vitro Techniques; Ligands; Lipid Bilayers; Models, Molecular; Naltrexone; Protein Conformation; Receptors, Opioid, delta; Recombinant Proteins; Surface Plasmon Resonance | 2000 |
Selective kappa-opioid antagonists related to naltrindole. Effect of side-chain spacer in the 5'-amidinoalkyl series.
Topics: Amidines; Animals; Benzeneacetamides; Binding, Competitive; Brain; Cell Membrane; Drug Design; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Guinea Pigs; Indicators and Reagents; Kinetics; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid, kappa; Structure-Activity Relationship | 2000 |
N-Cyclohexylethyl-N-noroxymorphindole: a mu-opioid preferring analogue of naltrindole.
Topics: Analgesics; Animals; Mice; Molecular Structure; Morphine; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Pain Measurement; Receptors, Opioid, mu | 2000 |
Expression of functional delta opioid receptors in vascular smooth muscle.
Topics: Animals; Aorta; Binding, Competitive; Calcium; Cell Line; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Gene Expression; Humans; In Vitro Techniques; Male; Membrane Potentials; Muscle, Smooth, Vascular; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; RNA, Messenger; Vasoconstriction | 2000 |
delta-, but not mu- and kappa-, opioid receptor activation protects neocortical neurons from glutamate-induced excitotoxic injury.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Cells, Cultured; Cytoprotection; Embryo, Mammalian; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Excitatory Amino Acid Agonists; Female; Glutamic Acid; L-Lactate Dehydrogenase; Naltrexone; Narcotic Antagonists; Neocortex; Neurons; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2000 |
Activation of G-proteins in the mouse pons/medulla by beta-endorphin is mediated by the stimulation of mu- and putative epsilon-receptors.
Topics: Animals; beta-Endorphin; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; In Vitro Techniques; Kinetics; Male; Medulla Oblongata; Mice; Naltrexone; Narcotic Antagonists; Pons; Receptors, Opioid; Receptors, Opioid, mu; Sulfur Radioisotopes | 2000 |
An immortalized myocyte cell line, HL-1, expresses a functional delta -opioid receptor.
Topics: Analgesics; Benzomorphans; Binding, Competitive; Cell Line; Cells, Cultured; Dose-Response Relationship, Drug; Enkephalin, Leucine-2-Alanine; Guanosine 5'-O-(3-Thiotriphosphate); Kinetics; Ligands; Myocardium; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Time Factors; Tumor Cells, Cultured | 2000 |
The role of opioid receptors in morphine withdrawal in the infant rat.
Topics: Animals; Animals, Newborn; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Long-Evans; Receptors, Opioid; Receptors, Opioid, mu; Somatostatin; Substance Withdrawal Syndrome | 2000 |
The effect of antagonists selective for mu- and delta-opioid receptor subtypes on alcohol consumption in C57BL/6 mice.
Topics: Alcohol Drinking; Animals; Male; Mice; Mice, Inbred C57BL; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Receptors, Opioid, mu; Somatostatin | 2000 |
Blockade of mu-opioid receptors reveals the hyperalgesic effect of orphanin FQ/nociceptin in the rat hot plate test.
Topics: Animals; Dose-Response Relationship, Drug; Female; Hot Temperature; Hyperalgesia; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptin; Opioid Peptides; Pain Measurement; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid, mu; Somatostatin | 2000 |
Antinociceptive effect produced by intracerebroventricularly administered dynorphin A is potentiated by p-hydroxymercuribenzoate or phosphoramidon in the mouse formalin test.
Topics: Animals; Brain; Cell Extracts; Drug Interactions; Dynorphins; Glycopeptides; Hydroxymercuribenzoates; Injections, Intraventricular; Mice; Naltrexone; Narcotic Antagonists; Nociceptors; Pain; Pain Measurement; Protease Inhibitors; Rats | 2001 |
Influence of maternal milk on functional activation of delta-opioid receptors in postnatal rats.
Topics: Analysis of Variance; Animals; Animals, Newborn; Female; Male; Milk; Naltrexone; Narcotic Antagonists; Psychomotor Performance; Rats; Rats, Wistar; Receptors, Opioid, delta; Swimming; Weaning | 2001 |
Suppression of ethanol responding by centrally administered CTOP and naltrindole in AA and Wistar rats.
Topics: Alcohol Drinking; Amygdala; Animals; Central Nervous System Depressants; Conditioning, Operant; Ethanol; Genotype; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Reinforcement, Psychology; Self Administration; Somatostatin | 2001 |
The human delta opioid receptor activates G(i1)alpha more efficiently than G(o1)alpha.
Topics: Adenylyl Cyclases; Cell Line; Colforsin; Diprenorphine; Enkephalin, Leucine-2-Alanine; GTP Phosphohydrolases; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine Triphosphate; Heterotrimeric GTP-Binding Proteins; Humans; Kinetics; Naltrexone; Polymerase Chain Reaction; Receptors, Opioid, delta; Recombinant Fusion Proteins; Recombinant Proteins; Transfection | 2001 |
Activity of mu- and delta-opioid agonists in vas deferens from mice deficient in MOR gene.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Female; Genotype; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Mutant Strains; Morphine; Muscle Contraction; Naltrexone; Narcotic Antagonists; Oligopeptides; Receptors, Opioid, delta; Receptors, Opioid, mu; Vas Deferens | 2001 |
Selective delta-opioid receptor ligands: potential PET ligands based on naltrindole.
Topics: Diagnostic Imaging; Ligands; Naltrexone; Narcotic Antagonists; Protein Binding; Receptors, Opioid, delta; Structure-Activity Relationship; Tomography, Emission-Computed | 2001 |
The role of minoxidil on endogenous opioid peptides in the spinal cord: a putative co-agonist relationship between K-ATP openers and opioids.
Topics: Adenosine Triphosphate; Animals; Dose-Response Relationship, Drug; Male; Minoxidil; Naltrexone; Narcotic Antagonists; Nociceptors; Opioid Peptides; Pain; Potassium Channels; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Spinal Cord; Vasodilator Agents | 2001 |
Blockade of delta opioid receptors in the ventrolateral periaqueductal gray region inhibits the fall in arterial pressure evoked by hemorrhage.
Topics: Animals; beta-Endorphin; Blood Pressure; Hemorrhage; Homocysteine; Male; Microinjections; Naloxone; Naltrexone; Narcotic Antagonists; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta | 2001 |
Endogenous opioids suppress activation of nociceptors by sub-nanomolar nicotine.
Topics: Adrenal Medulla; Analysis of Variance; Animals; Animals, Newborn; Bradykinin; Capsaicin; Dose-Response Relationship, Drug; Hexamethonium; Inflammation; Knee Joint; Male; Naloxone; Naltrexone; Narcotic Antagonists; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Nicotine; Nociceptors; Opioid Peptides; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Opioid; Sciatic Nerve; Time Factors | 2001 |
Enhancement of the effects of a complete inhibitor of enkephalin-catabolizing enzymes, RB 101, by a cholecystokinin-B receptor antagonist in diabetic rats.
Topics: Aminopeptidases; Animals; Diabetes Mellitus, Experimental; Disulfides; Drug Synergism; Indoles; Male; Meglumine; Naloxone; Naltrexone; Neprilysin; Pain; Pain Measurement; Phenylalanine; Pressure; Rats; Rats, Sprague-Dawley; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Time Factors; Vocalization, Animal; Weight Loss | 2001 |
Pharmacological characterization of the dermorphin analog [Dmt(1)]DALDA, a highly potent and selective mu-opioid peptide.
Topics: Analgesics; Animals; Drug Tolerance; Humans; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Oligodeoxyribonucleotides, Antisense; Oligopeptides; Opioid Peptides; Pain Measurement; Receptors, Opioid, mu; Time Factors | 2001 |
Respiratory function in adult mice lacking the mu-opioid receptor: role of delta-receptors.
Topics: Analgesics, Opioid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Female; Male; Medulla Oblongata; Mice; Mice, Knockout; Naltrexone; Narcotic Antagonists; Neurons; Oligopeptides; Organ Culture Techniques; Receptors, Opioid, delta; Receptors, Opioid, mu; Respiratory Center; Respiratory Physiological Phenomena | 2001 |
Endomorphins 1 and 2, endogenous mu-opioid receptor agonists, impair passive avoidance learning in mice.
Topics: Analgesics, Opioid; Animals; Avoidance Learning; Behavior, Animal; Dose-Response Relationship, Drug; Male; Mice; Naltrexone; Narcotic Antagonists; Oligopeptides; Receptors, Opioid, mu | 2001 |
Transformation of a kappa-opioid receptor antagonist to a kappa-agonist by transfer of a guanidinium group from the 5'- to 6'-position of naltrindole.
Topics: Animals; Cell Line; Cloning, Molecular; Guanidine; Guinea Pigs; Humans; In Vitro Techniques; Molecular Conformation; Muscle Contraction; Muscle, Smooth; Mutagenesis, Site-Directed; Naltrexone; Narcotic Antagonists; Rats; Receptors, Opioid, kappa; Structure-Activity Relationship; Transfection | 2001 |
Blockade of opioid receptors in rostral ventral medulla prevents antihyperalgesia produced by transcutaneous electrical nerve stimulation (TENS).
Topics: Analgesics, Opioid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Hot Temperature; Hyperalgesia; Male; Medulla Oblongata; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Transcutaneous Electric Nerve Stimulation | 2001 |
Probing the shape of a hydrophobic pocket in the active site of delta-opioid antagonists.
Topics: Amino Acid Substitution; Animals; Binding Sites; Binding, Competitive; Brain; Dipeptides; Isoquinolines; Molecular Conformation; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Tetrahydroisoquinolines; Thermodynamics; Tyrosine | 2001 |
Immunosuppression by delta-opioid antagonist naltrindole: delta- and triple mu/delta/kappa-opioid receptor knockout mice reveal a nonopioid activity.
Topics: Animals; Benzylidene Compounds; Cell Division; Concanavalin A; Dipeptides; Immunosuppressive Agents; Interleukin-2; Lymphocyte Culture Test, Mixed; Lymphocytes; Mice; Mice, Knockout; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, sigma; T-Lymphocytes; Tetrahydroisoquinolines | 2001 |
Mu- and delta-opioid receptor antagonists reduce levodopa-induced dyskinesia in the MPTP-lesioned primate model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Callithrix; Disease Models, Animal; Drug Therapy, Combination; Dyskinesias; Female; Hypokinesia; Levodopa; Male; Morphinans; Motor Activity; Naltrexone; Narcotic Antagonists; Parkinsonian Disorders; Posture; Receptors, Opioid, delta; Receptors, Opioid, mu | 2001 |
Opioid and GABA receptors involved in mediation and modulation of tonic and stimulus-evoked inhibition of a spinal reflex in the decerebrated and spinalized rabbit.
Topics: Animals; Bicuculline; Conditioning, Classical; Decerebrate State; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Methionine; Female; GABA Antagonists; Male; Muscle Tonus; Naloxone; Naltrexone; Narcotic Antagonists; Organophosphorus Compounds; Rabbits; Receptors, GABA; Receptors, Opioid; Receptors, Opioid, mu; Receptors, sigma; Reflex | 2001 |
Control of the efficiency of agonist-induced information transfer and stability of the ternary complex containing the delta opioid receptor and the alpha subunit of G(i1) by mutation of a receptor/G protein contact interface.
Topics: Cell Membrane; Cells, Cultured; Enkephalin, Leucine-2-Alanine; GTP Phosphohydrolases; GTP-Binding Proteins; Heterotrimeric GTP-Binding Proteins; Humans; Kinetics; Naltrexone; Narcotic Antagonists; Oligonucleotides, Antisense; Receptors, sigma; Recombinant Fusion Proteins; Transfection | 2001 |
SoRI 9409, a non-peptide opioid mu receptor agonist/delta receptor antagonist, fails to stimulate [35S]-GTP-gamma-S binding at cloned opioid receptors.
Topics: Analgesics; Analgesics, Opioid; Animals; Benzamides; Benzeneacetamides; Binding, Competitive; CHO Cells; Cloning, Molecular; Cricetinae; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Iodine Radioisotopes; Morphine; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Piperazines; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sulfur Radioisotopes; Tritium | 2001 |
Parallel synthesis and biological activity of a new class of high affinity and selective delta-opioid ligand.
Topics: Amides; Analgesics, Opioid; Animals; Benzamides; Brain; Catalysis; Combinatorial Chemistry Techniques; Guinea Pigs; Humans; Inhibitory Concentration 50; Isoquinolines; Ligands; Male; Maleimides; Membrane Proteins; Mice; Mice, Inbred ICR; Molecular Structure; Morphine; Naltrexone; Nerve Tissue Proteins; Pain Measurement; Phthalimides; Piperazines; Quinolines; Rats; Rats, Wistar; Receptors, Opioid, delta; Structure-Activity Relationship; Succinimides; Sulfonamides | 2001 |
Binding, pharmacological and immunological profiles of the delta-selective opioid receptor antagonist HS 378.
Topics: Animals; Brain; Cells, Cultured; Guanosine 5'-O-(3-Thiotriphosphate); Immunosuppressive Agents; Lymphocyte Activation; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; T-Lymphocytes | 2001 |
Naloxone fails to produce conditioned place aversion in mu-opioid receptor knock-out mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Avoidance Learning; Brain; Conditioning, Psychological; Dose-Response Relationship, Drug; Habituation, Psychophysiologic; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Opioid Peptides; Phenotype; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Synaptic Transmission | 2001 |
The effect of the leucopyrokinin analogue: [2-8]-leucopyrokinin on central opioid receptors in rats.
Topics: Analgesia; Analgesics; Animals; Dose-Response Relationship, Drug; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Oligopeptides; Peptide Fragments; Rats; Rats, Wistar; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tail; Time Factors | 2001 |
The neuropeptide FF analogue, 1DMe, acts as a functional opioid autoreceptor antagonist in the rat spinal cord.
Topics: Animals; Autoreceptors; Dose-Response Relationship, Drug; Enkephalin, Methionine; In Vitro Techniques; Leucine; Male; Naltrexone; Narcotic Antagonists; Oligopeptides; Potassium; Rats; Rats, Sprague-Dawley; Spinal Cord; Thiorphan | 2001 |
Desensitization of endogenously expressed delta-opioid receptors: no evidence for involvement of G protein-coupled receptor kinase 2.
Topics: Animals; beta-Adrenergic Receptor Kinases; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enkephalin, D-Penicillamine (2,5)-; G-Protein-Coupled Receptor Kinase 2; G-Protein-Coupled Receptor Kinase 3; G-Protein-Coupled Receptor Kinases; Hybrid Cells; Iloprost; Mice; Naltrexone; Protein Serine-Threonine Kinases; Rats; Receptors, Opioid, delta; Transfection; Tumor Cells, Cultured | 2001 |
[(11)C]-GR89696, a potent kappa opiate receptor radioligand; in vivo binding of the R and S enantiomers.
Topics: Adrenergic alpha-Agonists; Animals; Brain; Mice; Morphinans; Naltrexone; Narcotic Antagonists; Piperazines; Pyrrolidines; Receptors, Opioid, kappa; Stereoisomerism; Tissue Distribution | 2002 |
Comparison of the peripheral and central effects of the opioid agonists loperamide and morphine in the formalin test in rats.
Topics: Analgesics, Opioid; Animals; Antidiarrheals; Cisterna Magna; Dose-Response Relationship, Drug; Formaldehyde; Injections; Injections, Subcutaneous; Loperamide; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2002 |
Roles of endogenous opioid peptides in modulation of nocifensive response to formalin.
Topics: Animals; Antibodies, Blocking; Dynorphins; Endorphins; Enkephalins; Formaldehyde; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Pain Measurement; Receptors, Opioid; Somatostatin; Spinal Cord | 2002 |
Long-term potentiation in direct perforant path projections to the hippocampal CA3 region in vivo.
Topics: Animals; Dentate Gyrus; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Long-Term Potentiation; Male; Naltrexone; Narcotic Antagonists; Perforant Pathway; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, delta; Receptors, Opioid, mu; Somatostatin | 2002 |
[Role of delta opioid receptors and their ligands in the development of adaptive heart protection against arrhythmogenesis].
Topics: Adaptation, Physiological; Animals; Arrhythmias, Cardiac; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Ligands; Male; Myocardial Reperfusion Injury; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Rats; Rats, Wistar; Receptors, Opioid, delta; Tetrahydroisoquinolines; Thiorphan | 2001 |
Analysis of opioid receptor subtype antagonist effects upon mu opioid agonist-induced feeding elicited from the ventral tegmental area of rats.
Topics: Animals; Appetite Regulation; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Feeding Behavior; Male; Naltrexone; Narcotic Antagonists; Narcotics; Neural Pathways; Neurons; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Synaptic Transmission; Ventral Tegmental Area | 2002 |
Predominance of delta-opioid-binding sites in the porcine enteric nervous system.
Topics: Animals; Benzeneacetamides; Binding Sites; Cell Membrane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enteric Nervous System; Female; In Vitro Techniques; Intestinal Mucosa; Intestines; Male; Myenteric Plexus; Naltrexone; Narcotic Antagonists; Neurons; Pyrrolidines; Radioligand Assay; Radiopharmaceuticals; Receptors, Opioid, delta; Saxitoxin; Swine | 2002 |
Blockade of the antinociceptive effect of spinally administered kyotorphin by naltrindole in mice.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Endorphins; Injections, Spinal; Male; Mice; Naltrexone; Narcotic Antagonists; Pain Measurement; Receptors, Opioid, delta; Spinal Cord | 2002 |
Dynorphin A(1-17)-induced feeding: pharmacological characterization using selective opioid antagonists and antisense probes in rats.
Topics: Animals; Dose-Response Relationship, Drug; Drug Interactions; Dynorphins; Feeding Behavior; Male; Models, Animal; Naltrexone; Narcotic Antagonists; Oligonucleotides, Antisense; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2002 |
Neuroprotective role of delta-opioid receptors in cortical neurons.
Topics: Animals; Cell Count; Cell Differentiation; Cell Hypoxia; Cell Survival; Cells, Cultured; Cerebral Cortex; Enkephalin, Leucine-2-Alanine; Hypoxia, Brain; L-Lactate Dehydrogenase; Naltrexone; Narcotic Antagonists; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Time Factors | 2002 |
Delta opioid inhibition of light-induced phase advances in hamster circadian activity rhythms.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzamides; Biological Clocks; Circadian Rhythm; Cricetinae; Enkephalins; Light; Male; Mesocricetus; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Nerve Tissue Proteins; Opioid Peptides; Piperazines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Suprachiasmatic Nucleus | 2002 |
Anti-nociceptive effect of neuropeptide Y in the nucleus accumbens of rats: an involvement of opioid receptors in the effect.
Topics: Animals; Catheterization; Dose-Response Relationship, Drug; Hot Temperature; Male; Microinjections; Naloxone; Naltrexone; Narcotic Antagonists; Neuropeptide Y; Nucleus Accumbens; Pain Measurement; Peptide Fragments; Physical Stimulation; Rats; Rats, Wistar; Receptors, Neuropeptide Y; Receptors, Opioid | 2002 |
N1'-fluoroethyl-naltrindole (BU97001) and N1'-fluoroethyl-(14-formylamino)-naltrindole (BU97018) potential delta-opioid receptor PET ligands.
Topics: Animals; Autoradiography; Binding Sites; Brain; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; In Vitro Techniques; Male; Mice; Naltrexone; Radionuclide Imaging; Radiopharmaceuticals; Rats; Rats, Wistar; Receptors, Opioid, delta; Sensitivity and Specificity; Vas Deferens | 2002 |
The neuropeptide FF analogue, 1DMe, reduces in vivo dynorphin release from the rat spinal cord.
Topics: Animals; Dose-Response Relationship, Drug; Dynorphins; Injections, Spinal; Male; Models, Animal; Naltrexone; Narcotic Antagonists; Oligopeptides; Peptide Fragments; Perfusion; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin; Spinal Cord | 2002 |
Blockade of nigral and pallidal opioid receptors suppresses vacuous chewing movements in a rodent model of tardive dyskinesia.
Topics: Animals; Dose-Response Relationship, Drug; Dynorphins; Dyskinesia, Drug-Induced; Fluphenazine; Globus Pallidus; Male; Mastication; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Somatostatin; Substantia Nigra | 2002 |
Involvement of endogenous opioid systems in nociceptin-induced spinal antinociception in rats.
Topics: Animals; Endorphins; Hindlimb; Hot Temperature; Injections, Spinal; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptin; Nociceptors; Opioid Peptides; Pain; Pain Measurement; Peptide Fragments; Physical Stimulation; Rats; Rats, Sprague-Dawley; Spinal Cord | 2002 |
Involvement of the opioid system in the anxiolytic-like effects induced by Delta(9)-tetrahydrocannabinol.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Darkness; Dronabinol; Endorphins; Light; Male; Mice; Naltrexone; Narcotic Antagonists; Piperidines; Pyrazoles; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Rimonabant | 2002 |
Lack of the nociceptin receptor does not affect acute or chronic nociception in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Female; Male; Mice; Mice, Knockout; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptin; Nociceptin Receptor; Oligopeptides; Opioid Peptides; Pain; Receptors, Opioid; Time Factors; Vas Deferens | 2002 |
Different effects of methionine-enkephalin on paw edema in two inbred rat strains.
Topics: Animals; Dexamethasone; Dose-Response Relationship, Drug; Edema; Enkephalin, Methionine; Glucocorticoids; Inflammation; Kinetics; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Species Specificity; Time Factors | 2002 |
Effect of selective blockade of mu(1) or delta opioid receptors on reinstatement of alcohol-seeking behavior by drug-associated stimuli in rats.
Topics: Alcohol Drinking; Analysis of Variance; Animals; Central Nervous System Depressants; Cues; Discrimination, Psychological; Ethanol; Extinction, Psychological; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Reinforcement, Psychology; Self Administration | 2002 |
The role of delta-opioid receptors in estrogen facilitation of lordosis behavior.
Topics: Analgesics, Opioid; Animals; Autoradiography; Enkephalin, D-Penicillamine (2,5)-; Estrogens; Female; Microinjections; Naltrexone; Narcotic Antagonists; Ovariectomy; Posture; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Sexual Behavior, Animal; Stereotaxic Techniques; Ventromedial Hypothalamic Nucleus | 2002 |
Activation of delta-opioid receptors excites spinally projecting locus coeruleus neurons through inhibition of GABAergic inputs.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Analgesics, Opioid; Animals; Bicuculline; Dopamine beta-Hydroxylase; Electrophysiology; Enkephalin, D-Penicillamine (2,5)-; Excitatory Postsynaptic Potentials; GABA Antagonists; gamma-Aminobutyric Acid; Immunohistochemistry; Locus Coeruleus; Naltrexone; Narcotic Antagonists; Neural Pathways; Neurons; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Spinal Cord | 2002 |
Functional interactions between delta- and mu-opioid receptors in rat thermoregulation.
Topics: Animals; Body Temperature; Body Temperature Regulation; Dose-Response Relationship, Drug; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptor Cross-Talk; Receptors, Opioid, delta; Receptors, Opioid, mu | 2003 |
Agonist-specific down-regulation of the human delta-opioid receptor.
Topics: Amino Acid Sequence; Analgesics, Opioid; Animals; Benzamides; Binding, Competitive; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Down-Regulation; Enkephalin, D-Penicillamine (2,5)-; Humans; Molecular Sequence Data; Naltrexone; Pertussis Toxin; Phosphorylation; Piperazines; Radioligand Assay; Receptors, Opioid, delta; Recombinant Fusion Proteins; Sequence Deletion; Tritium | 2003 |
The role of the side chain in determining relative delta- and kappa-affinity in C5'-substituted analogues of naltrindole.
Topics: Amides; Amidines; Animals; CHO Cells; Cricetinae; Humans; Naltrexone; Narcotic Antagonists; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, kappa; Urea | 2003 |
Opioid receptor antagonists modulate Ca2+-activated K+ channels in mesenteric arterial smooth muscle cells of rats in hemorrhagic shock.
Topics: Animals; Calcium; Dose-Response Relationship, Drug; Down-Regulation; Electrophysiology; Kinetics; Membrane Potentials; Mesenteric Arteries; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Naloxone; Naltrexone; Narcotic Antagonists; Potassium Channels; Rats; Rats, Wistar; Shock, Hemorrhagic | 2003 |
Sufentanil-related respiratory depression and antinociception in the dog. Mediation by different receptor types.
Topics: Analgesics, Opioid; Animals; Blood Gas Analysis; Depression, Chemical; Dogs; Dose-Response Relationship, Drug; Evoked Potentials; Injections, Intraventricular; Male; Naltrexone; Narcotic Antagonists; Neurons, Afferent; Oxygen; Oxygen Consumption; Receptors, Opioid, delta; Receptors, Opioid, mu; Sufentanil | 2002 |
Opioid receptor subtypes involved in the regulation of prolactin secretion during pregnancy and lactation.
Topics: Animals; Female; Injections, Intraventricular; Lactation; Naltrexone; Narcotic Antagonists; Pituitary Gland; Pregnancy; Pregnancy, Animal; Prolactin; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2003 |
Effect of rubiscolin, a delta opioid peptide derived from Rubisco, on memory consolidation.
Topics: Administration, Oral; Animals; Avoidance Learning; Dose-Response Relationship, Drug; Injections, Intraventricular; Male; Memory; Mice; Naltrexone; Narcotic Antagonists; Peptide Fragments; Plant Proteins; Receptors, Opioid, delta; Ribulose-Bisphosphate Carboxylase | 2003 |
Effects of heroin and its metabolites on schedule-controlled responding and thermal nociception in rhesus monkeys: sensitivity to antagonism by quadazocine, naltrindole and beta-funaltrexamine.
Topics: Animals; Azocines; Behavior, Animal; Dose-Response Relationship, Drug; Food; Heroin; Hot Temperature; Macaca mulatta; Morphine; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Pain Measurement | 2003 |
Solid-phase synthesis of naltrindole derivatives using Fischer indole synthesis based on one-pot release and cyclization methodology.
Topics: Combinatorial Chemistry Techniques; Cyclization; Naltrexone | 2003 |
Effect of opioid receptor antagonists on hypothalamic-pituitary-adrenal activity in rhesus monkeys.
Topics: Adrenocorticotropic Hormone; Animals; Cinnamates; Dose-Response Relationship, Drug; Female; Hydrocortisone; Hypothalamo-Hypophyseal System; Macaca mulatta; Male; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Pituitary-Adrenal System | 2003 |
Activation of delta- and kappa-opioid receptors by opioid peptides protects cardiomyocytes via KATP channels.
Topics: Adenosine Triphosphate; Animals; Benzamides; Cardiotonic Agents; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, Methionine; Guanidines; Ischemic Preconditioning, Myocardial; Male; Mitochondria; Morphinans; Myocardial Ischemia; Myocytes, Cardiac; Naltrexone; Narcotic Antagonists; Potassium Channels; Rabbits; Receptors, Opioid, delta; Receptors, Opioid, kappa; Sarcolemma | 2003 |
Phosphorylation of activating transcription factor in murine splenocytes through delta opioid receptors.
Topics: Activating Transcription Factor 2; Animals; Blotting, Western; Cyclic AMP Response Element-Binding Protein; Enkephalin, Leucine-2-Alanine; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Naltrexone; Narcotic Antagonists; Phosphorylation; Receptors, Opioid, delta; Signal Transduction; Specific Pathogen-Free Organisms; Spleen; Transcription Factors | 2003 |
Morphine withdrawal precipitated by specific mu, delta or kappa opioid receptor antagonists: a c-Fos protein study in the rat central nervous system.
Topics: Animals; Behavior, Animal; Cell Count; Central Nervous System; Gene Expression Regulation; Immunohistochemistry; Male; Morphine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Narcotics; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 2003 |
Involvement of mesolimbic structures in short-term sodium depletion: in situ hybridization and ligand-binding analyses.
Topics: Animals; Autoradiography; Corpus Striatum; Desoxycorticosterone; Diuresis; Dopamine Antagonists; Dopamine Plasma Membrane Transport Proteins; Drinking; Dynorphins; Enkephalins; Furosemide; In Situ Hybridization; Limbic System; Male; Membrane Glycoproteins; Membrane Transport Proteins; Naltrexone; Narcotic Antagonists; Nerve Tissue Proteins; Nucleus Accumbens; Raclopride; Random Allocation; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sodium Chloride; Sodium Chloride, Dietary; Sodium, Dietary; Thirst; Water | 2003 |
Possible antinociceptive mechanisms of opioid receptor antagonists in the mouse formalin test.
Topics: 5,7-Dihydroxytryptamine; Animals; Behavior, Animal; Benzylamines; Formaldehyde; Injections, Intraperitoneal; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Pain Measurement; Receptors, Opioid, delta; Receptors, Opioid, mu | 2003 |
Antinociceptive properties of oxymorphazole in the mouse.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Injections, Spinal; Male; Mice; Morpholines; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Receptors, Opioid, delta; Receptors, Opioid, mu; Somatostatin; Time Factors | 2003 |
[Dual regulation by delta opioid receptor agonists on the delayed rectified potassium channels in NG108-15 cells].
Topics: Animals; Cell Membrane; Enkephalin, D-Penicillamine (2,5)-; Glioma; Hybrid Cells; Mice; Naloxone; Naltrexone; Neuroblastoma; Patch-Clamp Techniques; Potassium Channels, Inwardly Rectifying; Rats; Receptors, Opioid, delta; Tumor Cells, Cultured | 2003 |
Involvement of oxytocin in spinal antinociception in rats with inflammation.
Topics: Analgesics; Animals; Carrageenan; Hot Temperature; Inflammation; Injections, Spinal; Male; Naloxone; Naltrexone; Narcotic Antagonists; Oxytocin; Pain; Pain Measurement; Physical Stimulation; Rats; Rats, Wistar; Spinal Cord; Vasotocin | 2003 |
In vitro and ex vivo effects of a selective nociceptin/orphanin FQ (N/OFQ) peptide receptor antagonist, CompB, on specific binding of [3H]N/OFQ and [35S]GTPgammaS in rat brain and spinal cord.
Topics: Animals; Benzimidazoles; Binding, Competitive; Brain; Dose-Response Relationship, Drug; Guanosine Triphosphate; Injections, Intravenous; Male; Naltrexone; Narcotic Antagonists; Nociceptin Receptor; Opioid Peptides; Peptide Fragments; Piperidines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Spinal Cord | 2003 |
Leucine-enkephalin interrupts sympathetically mediated tachycardia prejunctionally in the canine sinoatrial node.
Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Bradycardia; Dogs; Enkephalin, Leucine; Female; Heart Rate; Male; Microdialysis; Naltrexone; Narcotic Antagonists; Norepinephrine; Receptors, Opioid; Sinoatrial Node; Sympathetic Nervous System; Tachycardia; Vagus Nerve | 2003 |
Pharmacological characterization of a 7-benzylidenenaltrexone-preferring opioid receptor in porcine ileal submucosa.
Topics: Amphibian Proteins; Animals; Anions; Benzamides; Benzylidene Compounds; Biological Transport, Active; Carrier Proteins; Diprenorphine; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Female; Gastrointestinal Motility; Ileum; Intestinal Mucosa; Male; Naltrexone; Neurons, Afferent; Oligopeptides; Piperazines; Quinolines; Receptors, Opioid, delta; Receptors, Opioid, mu; Swine; Tritium | 2003 |
Opioid interactions in rhesus monkeys: effects of delta + mu and delta + kappa agonists on schedule-controlled responding and thermal nociception.
Topics: Analgesics, Opioid; Animals; Benzamides; Benzeneacetamides; Benzomorphans; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Interactions; Hot Temperature; Macaca mulatta; Male; Naltrexone; Narcotic Antagonists; Pain; Piperazines; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reinforcement Schedule | 2003 |
HL-1 myocytes exhibit PKC and K(ATP) channel-dependent delta opioid preconditioning.
Topics: Alkaloids; Animals; Benzophenanthridines; Cell Line; Enkephalin, Leucine-2-Alanine; Enzyme Inhibitors; Heart; Ischemic Preconditioning, Myocardial; Kinetics; Membrane Proteins; Muscle Cells; Myocardial Reperfusion; Myocardium; Naltrexone; Phenanthridines; Potassium Channels; Protein Kinase C; Receptors, Opioid, delta | 2003 |
Delta opioid receptors are involved in morphine-induced inhibition of luteinizing hormone releasing hormone in SK-N-SH cells.
Topics: Analgesics, Opioid; Cell Line, Tumor; Dose-Response Relationship, Drug; Gonadotropin-Releasing Hormone; Humans; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Neuroblastoma; Receptors, Opioid, delta; Somatostatin | 2003 |
Delta-opioid agonist-stimulated inositol phosphate formation in isolated, rabbit iris-ciliary bodies: role of G(i/o) proteins and Gbetagamma-subunits.
Topics: Animals; Benzamides; Chromatography, Ion Exchange; Ciliary Body; Dose-Response Relationship, Drug; Eye Proteins; GTP-Binding Protein Regulators; GTP-Binding Proteins; Inositol Phosphates; Iris; Naltrexone; Narcotic Antagonists; Pertussis Toxin; Phosphoproteins; Piperazines; Rabbits; Receptors, Opioid, delta | 2003 |
Reassessment of buprenorphine in conditioned place preference: temporal and pharmacological considerations.
Topics: Animals; Buprenorphine; Conditioning, Operant; Dose-Response Relationship, Drug; Male; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Nociceptin Receptor; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, kappa; Time Factors | 2004 |
The delta-opioid receptor agonist (+)BW373U86 regulates BDNF mRNA expression in rats.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Antidepressive Agents; Behavior, Animal; Benzamides; Brain; Brain-Derived Neurotrophic Factor; Bupropion; Desipramine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Drug Tolerance; Gene Expression Regulation; Immobilization; In Situ Hybridization; Male; Midazolam; Naltrexone; Narcotic Antagonists; Piperazines; Rats; Rats, Sprague-Dawley; Receptor, trkB; Receptors, Opioid, delta; RNA, Messenger; Swimming; Time Factors; Up-Regulation | 2004 |
Antibody response and allogeneic mixed lymphocyte reaction in mu-, delta-, and kappa-opioid receptor knockout mice.
Topics: Analysis of Variance; Animals; Antibodies; Antibody Formation; Graft Rejection; Immunosuppression Therapy; In Vitro Techniques; Lymphocyte Culture Test, Mixed; Lymphocytes; Mice; Mice, Knockout; Naltrexone; Narcotic Antagonists; Receptors, Opioid | 2004 |
Reversal of ongoing thermal hyperalgesia in mice by a recombinant herpesvirus that encodes human preproenkephalin.
Topics: Administration, Cutaneous; Animals; Enkephalins; Gene Expression; Gene Transfer Techniques; Genetic Therapy; Genetic Vectors; Herpesviridae; Hyperalgesia; Immunohistochemistry; Mice; Naltrexone; Narcotic Antagonists; Oligopeptides; Peptide Fragments; Pertussis Toxin; Protein Precursors; Receptors, Opioid, mu; Receptors, sigma; Somatostatin | 2004 |
Differential opioid inhibition of C- and A delta- fiber mediated thermonociception after stimulation of the nucleus raphe magnus.
Topics: Analgesics, Opioid; Animals; Electric Stimulation; Female; Hot Temperature; Injections, Spinal; Naloxone; Naltrexone; Narcotic Antagonists; Nerve Fibers, Myelinated; Nerve Fibers, Unmyelinated; Neural Pathways; Nociceptors; Raphe Nuclei; Rats; Rats, Sprague-Dawley | 2004 |
Social learning about ethanol in preweanling rats: role of endogenous opioids.
Topics: Animals; Animals, Newborn; Behavior, Animal; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Ethanol; Learning; Naloxone; Naltrexone; Narcotic Antagonists; Random Allocation; Rats; Rats, Sprague-Dawley; Social Behavior; Weaning | 2004 |
Nonopioidergic mechanism mediating morphine-induced antianalgesia in the mouse spinal cord.
Topics: Analgesia; Animals; beta-Endorphin; Dizocilpine Maleate; Drug Interactions; Drug Tolerance; Dynorphins; Enkephalins; Male; Mice; Morphine; Naloxone; Naltrexone; Oligopeptides; Pain; Pain Measurement; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord; Substance P | 2004 |
Opioid receptor antagonists increase [Ca2+]i in rat arterial smooth muscle cells in hemorrhagic shock.
Topics: Animals; Calcium; Cell Separation; Mesenteric Arteries; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Shock, Hemorrhagic | 2004 |
delta-Opioid receptor antagonists inhibit GIRK channel currents in acutely dissociated brainstem neurons of rat.
Topics: Analgesics, Opioid; Animals; Animals, Newborn; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, D-Penicillamine (2,5)-; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Guanosine 5'-O-(3-Thiotriphosphate); Ionophores; Locus Coeruleus; Naltrexone; Narcotic Antagonists; Neurons; Norepinephrine; Nystatin; Patch-Clamp Techniques; Potassium Channels; Potassium Channels, Inwardly Rectifying; Raphe Nuclei; Rats; Serotonin; Thermolysin | 2004 |
Supraspinal and spinal cord opioid receptors are responsible for antinociception following intrathecal morphine injections.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Injections, Spinal; Male; Models, Animal; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Pain; Pain Threshold; Random Allocation; Rats; Rats, Wistar; Reaction Time; Receptors, Opioid; Spinal Cord; Tail | 2004 |
Differential regulation of hippocampal progenitor proliferation by opioid receptor antagonists in running and non-running spontaneously hypertensive rats.
Topics: Adrenocorticotropic Hormone; Animals; Behavior, Animal; beta-Endorphin; Bromodeoxyuridine; Cell Division; Corticosterone; Enkephalin, Methionine; Female; Hippocampus; Motor Activity; Naltrexone; Narcotic Antagonists; Narcotics; Physical Conditioning, Animal; Radioimmunoassay; Random Allocation; Rats; Rats, Inbred SHR; Receptors, Opioid; Running | 2004 |
Relative contribution of endogenous opioids to myocardial ischemic tolerance.
Topics: Animals; Dynorphins; Endorphins; Enkephalin, Methionine; In Vitro Techniques; Ischemic Preconditioning, Myocardial; Naltrexone; Narcotic Antagonists; Rabbits; Receptors, Opioid, delta; Receptors, Opioid, kappa; Recovery of Function; Ventricular Function, Left | 2004 |
Effect of novel non-peptidic delta opioid receptor antagonists on human T and B cell activation.
Topics: B-Lymphocytes; Cell Division; Cells, Cultured; Dose-Response Relationship, Drug; Humans; Immunosuppressive Agents; Interleukin-2; Lymphocyte Activation; Mitogens; Naltrexone; Receptors, Opioid, delta; T-Lymphocytes | 2004 |
A bivalent ligand (KDN-21) reveals spinal delta and kappa opioid receptors are organized as heterodimers that give rise to delta(1) and kappa(2) phenotypes. Selective targeting of delta-kappa heterodimers.
Topics: Animals; Cell Line; Humans; Ligands; Mice; Naltrexone; Oligopeptides; Phenotype; Receptors, Opioid, delta; Receptors, Opioid, kappa; Structure-Activity Relationship | 2004 |
Involvement of opioid receptors in the oxytocin-induced antinociception in the central nervous system of rats.
Topics: Animals; Central Nervous System; Male; Naloxone; Naltrexone; Narcotic Antagonists; Oxytocin; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2004 |
The antinociceptive effect of Delta9-tetrahydrocannabinol in the arthritic rat.
Topics: Animals; Arthritis, Experimental; Cannabinoid Receptor Antagonists; Dose-Response Relationship, Drug; Dronabinol; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Freund's Adjuvant; Injections, Intradermal; Injections, Intraperitoneal; Male; Morphine; Mycobacterium; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Opioid; Rimonabant | 2004 |
Opioid receptors and acetaminophen (paracetamol).
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Dynorphins; Endorphins; Enkephalins; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2004 |
A Tyr-W-MIF-1 analog containing D-Pro2 acts as a selective mu2-opioid receptor antagonist in the mouse.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Male; Mice; MSH Release-Inhibiting Hormone; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Receptors, Opioid, mu | 2005 |
Inhibition of akt/protein kinase B signaling by naltrindole in small cell lung cancer cells.
Topics: Apoptosis; Binding Sites; Carcinoma, Small Cell; Cell Growth Processes; Cell Line, Tumor; Cell Survival; Gene Expression; Humans; Lung Neoplasms; Naltrexone; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; RNA Interference; RNA, Small Interfering; Signal Transduction | 2004 |
Inverse agonism and neutral antagonism at wild-type and constitutively active mutant delta opioid receptors.
Topics: Alkaline Phosphatase; Benzamides; Cell Line; Dipeptides; Dose-Response Relationship, Drug; Enkephalin, Leucine; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Ligands; Mutation; Naltrexone; Narcotic Antagonists; Piperazines; Receptors, Opioid, delta; Structure-Activity Relationship | 2005 |
The development of tolerance to locomotor effects of morphine and the effect of various opioid receptor antagonists in rats chronically treated with morphine.
Topics: Animals; Behavior, Animal; Drug Interactions; Male; Morphine; Morphine Dependence; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Wistar; Time Factors | 2005 |
Extension of the Nenitzescu reaction to simple ketones provides an efficient route to 1'-alkyl-5'-hydroxynaltrindole analogues, potent and selective delta-opioid receptor antagonists.
Topics: Animals; CHO Cells; Cricetinae; Cricetulus; Humans; Isomerism; Ketones; Naltrexone; Radioligand Assay; Receptors, Opioid, delta | 2005 |
Delta-opioid receptor antagonists exhibit properties of partial delta-receptor agonists in isolated perfused heart.
Topics: Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Heart; In Vitro Techniques; Male; Myocardial Contraction; Myocardial Ischemia; Naltrexone; Oligopeptides; Perfusion; Quinolines; Rats; Rats, Wistar; Receptors, Opioid, delta | 2004 |
Characterisation of opioid receptors involved in modulating circular and longitudinal muscle contraction in the rat ileum.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enteric Nervous System; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Muscle Contraction; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu | 2005 |
Differentiation of opioid receptor preference by [Dmt1]endomorphin-2-mediated antinociception in the mouse.
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Hot Temperature; Injections, Intraventricular; Injections, Subcutaneous; Male; Mice; Naloxone; Naltrexone; Nociceptors; Oligopeptides; Pain; Pain Measurement; Receptors, Opioid, delta; Receptors, Opioid, mu; Tail; Time Factors | 2005 |
3D-QSAR comparative molecular field analysis on opioid receptor antagonists: pooling data from different studies.
Topics: Least-Squares Analysis; Ligands; Models, Molecular; Naltrexone; Narcotic Antagonists; Quantitative Structure-Activity Relationship; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Static Electricity | 2005 |
A bivalent ligand (KDAN-18) containing delta-antagonist and kappa-agonist pharmacophores bridges delta2 and kappa1 opioid receptor phenotypes.
Topics: Allosteric Regulation; Amides; Animals; Binding, Competitive; Cell Line; Humans; Injections, Spinal; Ligands; Mice; Naltrexone; Phenotype; Pyrrolidines; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, kappa; Structure-Activity Relationship | 2005 |
Involvement of the opioid system in the effects induced by nicotine on anxiety-like behaviour in mice.
Topics: Analysis of Variance; Animals; Anxiety Disorders; Behavior, Animal; Dose-Response Relationship, Drug; Drug Antagonism; Drug Synergism; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Maze Learning; Mecamylamine; Mice; Naltrexone; Narcotic Antagonists; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Receptors, Opioid | 2005 |
In vivo activation of a mutant mu-opioid receptor by naltrexone produces a potent analgesic effect but no tolerance: role of mu-receptor activation and delta-receptor blockade in morphine tolerance.
Topics: Animals; Benzamides; Dose-Response Relationship, Drug; Drug Delivery Systems; Drug Interactions; Drug Tolerance; Mice; Mice, Transgenic; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Pain Measurement; Piperazines; Receptors, Opioid, mu | 2005 |
Nalmefene induced elevation in serum prolactin in normal human volunteers: partial kappa opioid agonist activity?
Topics: Adolescent; Adult; Analgesics, Opioid; Animals; Benzeneacetamides; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Estradiol; Female; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Male; Naltrexone; Narcotic Antagonists; Prolactin; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2005 |
DPI-221 [4-((alpha-s)-alpha-((2s,5r)-2,5-dimethyl-4-(3-fluorobenzyl)-1-piperazinyl)benzyl)-N,N-diethylbenzamide]: a novel nonpeptide delta receptor agonist producing increased micturition interval in normal rats.
Topics: Animals; Benzhydryl Compounds; Blood Gas Analysis; Carbachol; Convulsants; Dose-Response Relationship, Drug; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Naltrexone; Narcotic Antagonists; Pain Measurement; Piperazines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Urinary Bladder; Urination; Vas Deferens | 2005 |
In vitro electrophysiologic effects of morphine in rabbit ventricular myocytes.
Topics: Action Potentials; Animals; Calcium; Calcium Channels, L-Type; Female; In Vitro Techniques; Male; Morphine; Myocytes, Cardiac; Naltrexone; Potassium Channels; Rabbits | 2005 |
Role of delta-opioid receptor subtypes in anxiety-related behaviors in the elevated plus-maze in rats.
Topics: Animals; Anxiety; Benzamides; Benzylidene Compounds; Blood Specimen Collection; Corticosterone; Male; Maze Learning; Naltrexone; Piperazines; Rats; Rats, Inbred Lew; Receptors, Opioid, delta | 2005 |
Effects of opioid antagonists and morphine in a hippocampal hypoxia/hypoglycemia model.
Topics: Analgesics, Opioid; Animals; Brain Chemistry; Evoked Potentials; Hippocampus; Hypoglycemia; Hypoxia, Brain; In Vitro Techniques; Male; Morphine; Naltrexone; Narcotic Antagonists; Neuroprotective Agents; Neurotoxicity Syndromes; Rats; Rats, Wistar; Reperfusion Injury | 2005 |
Physiological control of emotion-related behaviors by endogenous enkephalins involves essentially the delta opioid receptors.
Topics: Analysis of Variance; Animals; Anxiety; Behavior, Animal; Disulfides; Dose-Response Relationship, Drug; Drug Interactions; Emotions; Enkephalins; Enzyme Inhibitors; Exploratory Behavior; Freezing Reaction, Cataleptic; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Phenylalanine; Reaction Time; Receptors, Opioid, delta; Receptors, Opioid, mu; Swimming; Time Factors | 2005 |
Chronic pain induces anxiety with concomitant changes in opioidergic function in the amygdala.
Topics: Amygdala; Analgesics, Opioid; Analysis of Variance; Animals; Anxiety; Behavior, Animal; Benzamides; Chronic Disease; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Freund's Adjuvant; Guanosine 5'-O-(3-Thiotriphosphate); Injections, Intraventricular; Male; Maze Learning; Mice; Mice, Inbred C57BL; Naltrexone; Narcotic Antagonists; Narcotics; Pain; Pain Measurement; Piperazines; Protein Binding; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reaction Time; Sciatica; Somatostatin; Sulfur Isotopes; Time Factors; Tranquilizing Agents | 2006 |
Opioid receptors modulate recovery from consummatory successive negative contrast.
Topics: Animals; Conditioning, Operant; Consummatory Behavior; Inhibition, Psychological; Male; Naloxone; Naltrexone; Narcotic Antagonists; Random Allocation; Rats; Rats, Long-Evans; Receptors, Opioid; Reinforcement, Psychology | 2005 |
Delta opioid agonists attenuate TAT(1-72)-induced oxidative stress in SK-N-SH cells.
Topics: Benzamides; Cell Line, Tumor; Cell Membrane; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Fluoresceins; Free Radicals; Gene Products, tat; Humans; Molsidomine; Naltrexone; Narcotic Antagonists; Opioid Peptides; Oxidative Stress; Piperazines; Receptors, Opioid, delta; tat Gene Products, Human Immunodeficiency Virus | 2006 |
Antinociception, tolerance and withdrawal symptoms induced by 7-hydroxymitragynine, an alkaloid from the Thai medicinal herb Mitragyna speciosa.
Topics: Analgesics; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Injections, Subcutaneous; Male; Mice; Mitragyna; Models, Molecular; Morphinans; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Reaction Time; Secologanin Tryptamine Alkaloids; Substance Withdrawal Syndrome; Thailand | 2005 |
An efficient intrathecal delivery of small interfering RNA to the spinal cord and peripheral neurons.
Topics: Animals; Cell Line; Ganglia, Spinal; Gene Expression Regulation; Gene Knockdown Techniques; Injections, Spinal; Lumbar Vertebrae; Naltrexone; Neurons; Nociceptors; Oligopeptides; Pain Measurement; Peripheral Nervous System; Posterior Horn Cells; Quinolinium Compounds; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; RNA, Messenger; RNA, Small Interfering; Spinal Cord | 2005 |
Structural determination of the novel fragmentation routes of morphine opiate receptor antagonists using electrospray ionization quadrupole time-of-flight tandem mass spectrometry.
Topics: Mesylates; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu; Spectrometry, Mass, Electrospray Ionization | 2005 |
Pharmacological study on the novel antinociceptive agent, a novel monoterpene alkaloid from Incarvillea sinensis.
Topics: Alkaloids; Analgesics; Bignoniaceae; Monoterpenes; Naltrexone; Narcotic Antagonists; Purinergic P1 Receptor Antagonists | 2005 |
Affinity identification of delta-opioid receptors using latex nanoparticles.
Topics: Animals; Chemistry, Pharmaceutical; CHO Cells; Cricetinae; Cytosol; Enkephalins; Latex; Models, Chemical; Naltrexone; Nanostructures; Protein Binding; Receptors, Opioid; Receptors, Opioid, delta; Recombinant Proteins | 2006 |
High-frequency, but not low-frequency, transcutaneous electrical nerve stimulation reduces aspartate and glutamate release in the spinal cord dorsal horn.
Topics: Animals; Arthritis, Experimental; Aspartic Acid; Carrageenan; Chromatography, High Pressure Liquid; Glutamic Acid; Joints; Microdialysis; Naltrexone; Narcotic Antagonists; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Transcutaneous Electric Nerve Stimulation | 2005 |
Antinociceptive effect of oxycodone in diabetic mice.
Topics: Analgesics, Opioid; Animals; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Narcotic Antagonists; Oxycodone; Pain; Pain Measurement; Time Factors | 2005 |
Effects of the local administration of selective mu-, delta-and kappa-opioid receptor agonists on osteosarcoma-induced hyperalgesia.
Topics: Analgesics, Opioid; Animals; Bone Neoplasms; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Hyperalgesia; Mice; Morphinans; Naltrexone; Narcotic Antagonists; Osteosarcoma; Receptors, Opioid | 2005 |
Kappa-opioid receptor-mediated effects of the plant-derived hallucinogen, salvinorin A, on inverted screen performance in the mouse.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Benzeneacetamides; Diterpenes; Diterpenes, Clerodane; Hallucinogens; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Piperidines; Psychotropic Drugs; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Remifentanil | 2005 |
Reduction of Submissive Behavior Model for antidepressant drug activity testing: study using a video-tracking system.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Competitive Behavior; Dominance-Subordination; Feeding Behavior; Fluoxetine; Imipramine; Maprotiline; Mice; Naltrexone; Narcotic Antagonists; Rats | 2005 |
Localization of opioid receptor antagonist [3H]-LY255582 binding sites in mouse brain: comparison with the distribution of mu, delta and kappa binding sites.
Topics: Animals; Autoradiography; Binding Sites; Brain; Cyclohexanes; Mice; Mice, Knockout; Molecular Structure; Naloxone; Naltrexone; Narcotic Antagonists; Piperidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tritium | 2005 |
Involvement of delta1-opioid receptors in the spatial learning impairment in streptozotocin-induced diabetic mice.
Topics: Animals; Benzylidene Compounds; Diabetes Mellitus, Experimental; Enkephalins; Escape Reaction; Mice; Naltrexone; Reaction Time; Receptors, Opioid, delta; Space Perception | 2005 |
Antinociceptive effect of shakuyakukanzoto, a Kampo medicine, in diabetic mice.
Topics: Adrenergic alpha-Antagonists; Analgesics; Animals; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Drug Combinations; Drugs, Chinese Herbal; Glycyrrhiza; Male; Medicine, Kampo; Methysergide; Mice; Naltrexone; Narcotic Antagonists; Oxidopamine; Paeonia; Pain Measurement; Pain Threshold; Piperazines; Serotonin Antagonists; Sympatholytics; Tropanes; Yohimbine | 2005 |
Opioid-induced tolerance and dependence in mice is modulated by the distance between pharmacophores in a bivalent ligand series.
Topics: Analgesics; Analgesics, Opioid; Animals; Chemistry, Pharmaceutical; Dose-Response Relationship, Drug; Ligands; Male; Mice; Mice, Inbred ICR; Models, Chemical; Models, Statistical; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Receptors, Opioid, delta; Receptors, Opioid, mu; Time Factors | 2005 |
Behavioral and neurobiological effects of the enkephalinase inhibitor RB101 relative to its antidepressant effects.
Topics: Adrenocorticotropic Hormone; Animals; Antidepressive Agents; Behavior, Animal; Benzamides; Brain-Derived Neurotrophic Factor; Disulfides; Dose-Response Relationship, Drug; Electroencephalography; Enzyme Inhibitors; Frontal Lobe; Hippocampus; Injections, Intravenous; Male; Motor Activity; Naltrexone; Narcotic Antagonists; Neprilysin; Phenylalanine; Piperazines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Swimming | 2006 |
Cannabidiol is an allosteric modulator at mu- and delta-opioid receptors.
Topics: Allosteric Regulation; Analgesics, Opioid; Animals; Cannabidiol; Cerebral Cortex; Dose-Response Relationship, Drug; Dronabinol; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu | 2006 |
Involvements of mu- and kappa-opioid receptors in morphine-induced antinociception in the nucleus accumbens of rats.
Topics: Analgesics, Opioid; Animals; Male; Morphine; Naloxone; Naltrexone; Nucleus Accumbens; Pain; Physical Stimulation; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2006 |
Delta opioid receptor ligands modulate anxiety-like behaviors in the rat.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Benzamides; Dose-Response Relationship, Drug; Male; Naltrexone; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta | 2006 |
Rapid hypoxia preconditioning protects cortical neurons from glutamate toxicity through delta-opioid receptor.
Topics: Animals; Cells, Cultured; Cellular Senescence; Cerebral Cortex; Enkephalin, Leucine-2-Alanine; Glutamic Acid; Hypoxia; Ischemic Preconditioning; L-Lactate Dehydrogenase; N-Methylaspartate; Naltrexone; Narcotic Antagonists; Neurons; Rats; Receptors, Opioid, delta; RNA, Messenger; Time Factors; Up-Regulation | 2006 |
Endogenous opioids upregulate brain-derived neurotrophic factor mRNA through delta- and micro-opioid receptors independent of antidepressant-like effects.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Autoradiography; Behavior, Animal; Benzamides; Brain-Derived Neurotrophic Factor; Dose-Response Relationship, Drug; Drug Interactions; Freezing Reaction, Cataleptic; In Situ Hybridization; Injections, Intraventricular; Male; Naltrexone; Narcotics; Opioid Peptides; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; RNA, Messenger; Swimming; Up-Regulation | 2006 |
Opioid receptors in the nucleus accumbens regulate attentional learning in the blocking paradigm.
Topics: Analgesics, Opioid; Animals; Attention; Electroshock; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Learning; Male; Models, Animal; Morphine; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Physical Stimulation; Rats; Rats, Wistar; Receptors, Opioid | 2006 |
Involvement of mu- and delta-opioid receptors in the antinociceptive effects induced by AMPA receptor antagonist in the spinal cord of rats.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Interactions; Male; Naltrexone; Pain Measurement; Physical Stimulation; Quinoxalines; Rats; Rats, Wistar; Reaction Time; Receptors, AMPA; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord; Wakefulness | 2006 |
Chronic pain-induced emotional dysfunction is associated with astrogliosis due to cortical delta-opioid receptor dysfunction.
Topics: Animals; Anxiety Disorders; Astrocytes; Brain Tissue Transplantation; Cells, Cultured; Cerebral Cortex; Chronic Disease; Culture Media, Conditioned; Disease Models, Animal; Gliosis; Gyrus Cinguli; Male; Mice; Mice, Inbred C57BL; Naltrexone; Narcotic Antagonists; Neuralgia; Pain, Intractable; Peripheral Nervous System Diseases; Receptors, Opioid, delta; Sciatic Neuropathy; Stem Cells | 2006 |
The involvement of endogenous opioid mechanisms in the antinociceptive effects induced by antidepressant drugs, desipramine and trimipramine.
Topics: Analgesics; Animals; Antidepressive Agents; Desipramine; Male; Mice; Morphine; Naloxone; Naltrexone; Receptors, Opioid; Receptors, Opioid, delta; Trimipramine | 2006 |
Potent in vivo antinociception and opioid receptor preference of the novel analogue [Dmt1]endomorphin-1.
Topics: Analgesia; Animals; Brain; Guinea Pigs; Ileum; Injections, Intraventricular; Male; Mice; Naloxone; Naltrexone; Oligopeptides; Pain; Pain Measurement; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord; Tail; Vas Deferens | 2006 |
Atypical anxiolytic-like response to naloxone in benzodiazepine-resistant 129S2/SvHsd mice: role of opioid receptor subtypes.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Drug Resistance; Male; Maze Learning; Mice; Mice, Inbred C57BL; Naloxone; Naltrexone; Opioid Peptides; Receptors, Opioid; Species Specificity | 2006 |
The antinociceptive effect of salvinorin A in mice.
Topics: Analgesics; Animals; Diterpenes; Diterpenes, Clerodane; Injections, Spinal; Male; Mice; Naltrexone | 2006 |
Beta-endorphin differentially affects inflammation in two inbred rat strains.
Topics: Animals; beta-Endorphin; Concanavalin A; Dose-Response Relationship, Drug; Edema; Female; Granulocytes; Hindlimb; Inflammation; Male; Naltrexone; Narcotic Antagonists; Neurotransmitter Agents; Nitric Oxide; Phagocytosis; Rats; Rats, Inbred Strains; Receptors, Opioid, delta; Receptors, Opioid, kappa; Species Specificity | 2006 |
Regulation of pancreatic secretion in vitro by nociceptin/orphanin FQ and opioid receptors: a comparative study.
Topics: Amylases; Animals; Guinea Pigs; In Vitro Techniques; Naltrexone; Narcotic Antagonists; Nociceptin Receptor; Oligopeptides; Opioid Peptides; Pancreas; Receptors, Opioid | 2006 |
Striatal delta opioid receptor binding in experimental models of Parkinson's disease and dyskinesia.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Analysis of Variance; Animals; Corpus Striatum; Disease Models, Animal; Dopamine Plasma Membrane Transport Proteins; Dyskinesias; Macaca mulatta; Male; Naltrexone; Narcotic Antagonists; Parkinson Disease; Prosencephalon; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Reserpine; Tritium | 2007 |
Involvement of opioid receptors in oxytocin-induced antinociception in the nucleus accumbens of rats.
Topics: Analgesics; Animals; Hot Temperature; Male; Microinjections; Naloxone; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Oxytocin; Pain Measurement; Physical Stimulation; Rats; Rats, Wistar; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2007 |
The role of delta opioid receptors in the anxiolytic actions of benzodiazepines.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Diazepam; Enkephalins; Male; Maze Learning; Naltrexone; Rats; Rats, Long-Evans; Receptors, GABA-A; Receptors, Opioid, delta | 2006 |
Activators of potassium M currents have anticonvulsant actions in two rat models of encephalitis.
Topics: Aminopyridines; Analgesics; Animals; Anticonvulsants; Borna Disease; Encephalitis, Viral; Herpes Simplex; Herpesvirus 1, Human; Male; Naloxone; Naltrexone; Narcotic Antagonists; Potassium; Rats; Rats, Inbred Lew; Receptors, Opioid, delta; Seizures; Substance Withdrawal Syndrome | 2007 |
Inhibition of tolerance to spinal morphine antinociception by low doses of opioid receptor antagonists.
Topics: Animals; Dose-Response Relationship, Drug; Drug Tolerance; Hyperalgesia; Injections, Spinal; Male; Morphine; Naltrexone; Narcotic Antagonists; Peptide Fragments; Peptides; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Somatostatin; Theophylline | 2007 |
Effect of beta-endorphin on production of antibodies and IL-4 under conditions of opioid receptor blockade.
Topics: Animals; Antibody Formation; beta-Endorphin; Dose-Response Relationship, Drug; Hypersensitivity, Delayed; Interleukin-4; Lymphocyte Activation; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Phytohemagglutinins | 2006 |
Involvement of delta-and mu-opioid receptors in the delayed cerebral ischemic tolerance induced by repeated electroacupuncture preconditioning in rats.
Topics: Animals; Brain Ischemia; Electroacupuncture; Enkephalin, Methionine; Immunohistochemistry; Ischemic Preconditioning; Male; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Somatostatin | 2007 |
Anisomycin protects cortical neurons from prolonged hypoxia with differential regulation of p38 and ERK.
Topics: Animals; Anisomycin; Cell Hypoxia; Cells, Cultured; Cerebral Cortex; Extracellular Signal-Regulated MAP Kinases; Fetus; Immunoblotting; Naltrexone; Narcotic Antagonists; Neurons; Neuroprotective Agents; p38 Mitogen-Activated Protein Kinases; Rats | 2007 |
Selectivity of delta- and kappa-opioid ligands depends on the route of central administration in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzylidene Compounds; Enkephalin, D-Penicillamine (2,5)-; Injections, Intraventricular; Injections, Spinal; Ligands; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Receptors, Opioid, kappa | 2007 |
Indium-labeled macrocyclic conjugates of naltrindole: high-affinity radioligands for in vivo studies of peripheral delta opioid receptors.
Topics: Aldehydes; Animals; Autoradiography; Binding, Competitive; Guinea Pigs; Heterocyclic Compounds, 1-Ring; In Vitro Techniques; Indium Radioisotopes; Ligands; Macrocyclic Compounds; Male; Mice; Naltrexone; Radioligand Assay; Radiopharmaceuticals; Receptors, Opioid, delta; Structure-Activity Relationship; Tissue Distribution | 2007 |
Delta receptor antagonism, ethanol taste reactivity, and ethanol consumption in outbred male rats.
Topics: Alcohol Deterrents; Alcohol Drinking; Animals; Behavior, Animal; Central Nervous System Depressants; Dose-Response Relationship, Drug; Ethanol; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Long-Evans; Receptors, Opioid, delta; Reproducibility of Results; Self Administration; Taste | 2006 |
Pharmacological studies with a nonpeptidic, delta-opioid (-)-(1R,5R,9R)-5,9-dimethyl-2'-hydroxy-2-(6-hydroxyhexyl)-6,7-benzomorphan hydrochloride ((-)-NIH 11082).
Topics: Analgesics, Opioid; Animals; Arthritis, Experimental; Benzomorphans; Female; Hot Temperature; Macaca mulatta; Male; Mice; Mice, Inbred ICR; Morphine Dependence; Naltrexone; Narcotic Antagonists; Pain; Rats; Rats, Inbred Lew; Receptors, Opioid, delta; Stereoisomerism; Substance Withdrawal Syndrome | 2007 |
NIH 11082 produces anti-depressant-like activity in the mouse tail-suspension test through a delta-opioid receptor mechanism of action.
Topics: Animals; Antidepressive Agents; Benzomorphans; Male; Mice; Mice, Inbred C57BL; Motor Activity; Naltrexone; Narcotic Antagonists; Nicotinic Agonists; Receptors, Opioid, delta; Tail | 2007 |
Augmentation of spinal morphine analgesia and inhibition of tolerance by low doses of mu- and delta-opioid receptor antagonists.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Injections, Spinal; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Peptide Fragments; Peptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Somatostatin | 2007 |
Effects of selective opioid receptor antagonists on alcohol-induced and nicotine-induced antinociception.
Topics: Analgesics; Animals; Central Nervous System Depressants; Ethanol; Hot Temperature; Male; Naltrexone; Narcotic Antagonists; Nicotine; Nicotinic Agonists; Pain Measurement; Peptide Fragments; Peptides; Rats; Rats, Wistar; Reaction Time; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin | 2007 |
o-Naphthalenedicarboxaldehyde derivative of 7'-aminonaltrindole as a selective delta-opioid receptor affinity label.
Topics: Affinity Labels; Magnetic Resonance Spectroscopy; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Spectrometry, Mass, Fast Atom Bombardment | 2007 |
Relative contribution of peripheral versus central opioid receptors to antinociception.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetic Acid; Analgesics, Non-Narcotic; Analgesics, Opioid; Analysis of Variance; Animals; Calcitonin Gene-Related Peptide; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Interactions; Gene Expression; Loperamide; Male; Mice; Mice, Inbred C57BL; Naltrexone; Narcotic Antagonists; Pain; Receptors, Opioid | 2007 |
Dose-dependent neuroprotection of delta opioid peptide [D-Ala2, D-Leu5] enkephalin in neuronal death and retarded behavior induced by forebrain ischemia in rats.
Topics: Animals; Behavior, Animal; Brain Ischemia; Cell Death; Dose-Response Relationship, Drug; Enkephalin, Leucine-2-Alanine; Injections, Intraventricular; Male; Naltrexone; Narcotic Antagonists; Neurons; Neuroprotective Agents; Prosencephalon; Rats; Rats, Sprague-Dawley | 2007 |
Effects of delta-opioid receptor stimulation and inhibition on hippocampal survival in a rat model of forebrain ischaemia.
Topics: Animals; Brain Ischemia; Cell Survival; Drug Evaluation, Preclinical; Enkephalin, Leucine-2-Alanine; Hippocampus; Male; Naltrexone; Narcotic Antagonists; Neurons; Neuroprotective Agents; Prosencephalon; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta | 2007 |
Involvement of kappa opioid receptors in formalin-induced inhibition of analgesic tolerance to morphine in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Chronic Disease; Drug Tolerance; Formaldehyde; Male; Mice; Morphine; Naltrexone; Oligonucleotides, Antisense; Pain; Pain Measurement; Pain Threshold; Receptors, Opioid, delta; Receptors, Opioid, kappa; Tail | 2007 |
Intramuscular administration of morphine reduces mustard-oil-induced craniofacial-muscle pain behavior in lightly anesthetized rats.
Topics: Analgesics; Anesthesia, General; Animals; Inflammation; Injections; Injections, Intramuscular; Male; Masseter Muscle; Morphine; Mustard Plant; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Pain; Plant Oils; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Single-Blind Method; Somatostatin | 2008 |
Pharmacological selectivity of CTAP in a warm water tail-withdrawal antinociception assay in rats.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Injections, Intraventricular; Injections, Subcutaneous; Male; Naltrexone; Narcotic Antagonists; Pain Threshold; Peptide Fragments; Peptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin; Tail; Thermosensing | 2008 |
Use of preproenkephalin knockout mice and selective inhibitors of enkephalinases to investigate the role of enkephalins in various behaviours.
Topics: Analysis of Variance; Animals; Behavior, Animal; CD13 Antigens; Disulfides; Dose-Response Relationship, Drug; Enkephalins; Enzyme Inhibitors; Injections, Intravenous; Mice; Mice, Inbred DBA; Mice, Knockout; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Neprilysin; Phenylalanine; Protein Precursors; Swimming | 2008 |
delta-Opioid receptor stimulation enhances the growth of neonatal rat ventricular myocytes via the extracellular signal-regulated kinase pathway.
Topics: Analgesics, Opioid; Animals; Animals, Newborn; Butadienes; Cell Proliferation; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cytoskeleton; Dose-Response Relationship, Drug; Enkephalin, Leucine-2-Alanine; Extracellular Signal-Regulated MAP Kinases; Heart Ventricles; Myocytes, Cardiac; Naltrexone; Narcotic Antagonists; Nitriles; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Signal Transduction; Staurosporine; Thionucleotides; Time Factors | 2008 |
YFa, a chimeric opioid peptide, induces kappa-specific antinociception with no tolerance development during 6 days of chronic treatment.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, Methionine; FMRFamide; Gene Expression Regulation; Male; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain Measurement; Rats; Rats, Wistar; Reaction Time; Receptors, Opioid, kappa; Receptors, Opioid, mu; Time Factors | 2008 |
Methionine-enkephalin modulation of hydrogen peroxide (H2O2) release by rat peritoneal macrophages involves different types of opioid receptors.
Topics: Animals; Benzylidene Compounds; Carcinogens; Dose-Response Relationship, Drug; Enkephalin, Methionine; Hydrogen Peroxide; Macrophages, Peritoneal; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tetradecanoylphorbol Acetate | 2008 |
Activation of δ-opioid receptors inhibits L-type Ca(2+) current and transient outward K(+) current in rat ventricular myocytes.
Topics: Animals; Anti-Arrhythmia Agents; Benzamides; Calcium Channels, L-Type; Cells, Cultured; Heart Ventricles; Myocytes, Cardiac; Naltrexone; Patch-Clamp Techniques; Piperazines; Potassium Channels; Rats; Receptors, Opioid, delta | 2008 |
Dopamine-independent psychostimulant activity of a delta-agonist.
Topics: Animals; Benzamides; Brain; Central Nervous System Stimulants; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Synergism; Haloperidol; Male; Mice; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Piperazines; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Opioid, delta | 2008 |
Distinct inhibition of voltage-activated Ca2+ channels by delta-opioid agonists in dorsal root ganglion neurons devoid of functional T-type Ca2+ currents.
Topics: Analgesics, Opioid; Animals; Calcium Channel Blockers; Calcium Channels, T-Type; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Enkephalin, D-Penicillamine (2,5)-; Ganglia, Spinal; Glycoproteins; Lectins; Male; Membrane Potentials; Naltrexone; Narcotic Antagonists; Neural Inhibition; Neurons, Afferent; Oligopeptides; omega-Conotoxin GVIA; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Versicans | 2008 |
Mu-opioid receptor in the nucleus submedius: involvement in opioid-induced inhibition of mirror-image allodynia in a rat model of neuropathic pain.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Enkephalin, Leucine-2-Alanine; Hyperalgesia; Ligation; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Neuralgia; Oligopeptides; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Spinal Nerves; Thalamic Nuclei | 2008 |
The spinal antinociceptive effects of endomorphins in rats: behavioral and G protein functional studies.
Topics: Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Partial Agonism; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Guanosine 5'-O-(3-Thiotriphosphate); Injections, Spinal; Male; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Spinal Cord; Sulfur Radioisotopes; Thalamus; Time Factors | 2008 |
Inhibition of the development of morphine tolerance by a potent dual mu-delta-opioid antagonist, H-Dmt-Tic-Lys-NH-CH2-Ph.
Topics: Analgesics, Opioid; Animals; Area Under Curve; Dose-Response Relationship, Drug; Drug Tolerance; Injections, Intraventricular; Injections, Subcutaneous; Ligands; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Oligopeptides; Reaction Time; Receptors, Opioid, delta; Receptors, Opioid, mu; Somatostatin | 2008 |
Removing TRPV1-expressing primary afferent neurons potentiates the spinal analgesic effect of delta-opioid agonists on mechano-nociception.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Behavior, Animal; Diterpenes; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Gene Expression Regulation; Hyperalgesia; Male; Naltrexone; Oligopeptides; Pain Threshold; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Sensory Receptor Cells; Spinal Cord; Tritium; TRPV Cation Channels | 2008 |
Roles of opioid receptor subtypes on the antinociceptive effect of intrathecal sildenafil in the formalin test of rats.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Interactions; Guanidines; Male; Morphinans; Naltrexone; Narcotic Antagonists; Pain Measurement; Pain Threshold; Phosphodiesterase Inhibitors; Piperazines; Purines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Sildenafil Citrate; Somatostatin; Sulfones; Time Factors | 2008 |
The selective delta opioid agonist SNC80 enhances amphetamine-mediated efflux of dopamine from rat striatum.
Topics: Amphetamine; Analgesics, Opioid; Analysis of Variance; Animals; Area Under Curve; Benzamides; Corpus Striatum; Dopamine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Male; Naltrexone; Narcotic Antagonists; Piperazines; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Subcellular Fractions; Time Factors; Tritium | 2008 |
Structure-antitussive activity relationships of naltrindole derivatives. Identification of novel and potent antitussive agents.
Topics: Alkylation; Animals; Antitussive Agents; Capsaicin; CHO Cells; Cough; Cricetinae; Cricetulus; Male; Mice; Molecular Structure; Naltrexone; Rats; Structure-Activity Relationship | 2008 |
[Effects of intracerebroventricular injection of delta-opioid receptor agonist TAN-67 or antagonist naltrindole on acute cerebral ischemia in rat].
Topics: Animals; Brain; Brain Ischemia; Infarction, Middle Cerebral Artery; Injections, Intraventricular; Naltrexone; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Reperfusion Injury | 2008 |
Augmentation of morphine-induced sensitization but reduction in morphine tolerance and reward in delta-opioid receptor knockout mice.
Topics: Animals; Conditioning, Psychological; Drug Tolerance; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Reward; Spatial Behavior | 2009 |
Antinociceptive action of 4-methyl-5-trifluoromethyl-5-hydroxy-4, 5-dihydro-1H-pyrazole methyl ester in models of inflammatory pain in mice.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Dipyrone; Freund's Adjuvant; Indomethacin; Inflammation; Male; Mice; Morphine; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Pain, Postoperative; Postural Balance; Pyrazoles; Stomach Ulcer | 2008 |
delta-Opioid receptor antagonism induces NMDA receptor-dependent excitotoxicity in anoxic turtle cortex.
Topics: Animals; Calcium; Cells, Cultured; Cerebral Cortex; Electrophysiology; Homeostasis; Hypoxia, Brain; In Vitro Techniques; Intercellular Signaling Peptides and Proteins; Naltrexone; Neurons; Neurotoxins; Patch-Clamp Techniques; Peptides; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, delta; Turtles | 2008 |
Delta-opioid receptor antagonists prevent sensitization to the conditioned rewarding effects of morphine.
Topics: Analysis of Variance; Animals; Association Learning; Behavior, Animal; Benzylidene Compounds; Conditioning, Classical; Disease Models, Animal; Male; Morphine Dependence; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptor Cross-Talk; Receptors, Opioid, delta; Receptors, Opioid, mu; Reinforcement, Psychology; Statistics, Nonparametric | 2009 |
[Analysis of central mechanisms involved in gastric mucosal integrity].
Topics: Animals; Arachidonic Acids; beta-Endorphin; Clonidine; Endocannabinoids; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Ethanol; Excitatory Amino Acids; Gastric Mucosa; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Neurotransmitter Agents; Nociceptin; Oligopeptides; Opioid Peptides; Oxazoles; Polyunsaturated Alkamides; Rats; Rats, Wistar; Receptors, Opioid; Rilmenidine; Stomach Ulcer | 2008 |
Role of delta opioid efficacy as a determinant of mu/delta opioid interactions in rhesus monkeys.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Interactions; Fentanyl; Hot Temperature; Ligands; Macaca mulatta; Naltrexone; Pain; Pain Measurement; Receptors, Opioid, delta; Receptors, Opioid, mu | 2009 |
Novel role for the delta-opioid receptor in hypoxic preconditioning in rat retinas.
Topics: Animals; Antioxidants; Blotting, Western; Dinoprost; Enkephalin, Leucine; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Intraocular Pressure; Ischemic Preconditioning; Lipid Peroxidation; Male; Naltrexone; Narcotic Antagonists; Oxidative Stress; Rats; Rats, Wistar; Receptors, Opioid, delta; Retina; Retinal Vessels; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Signal Transduction; Spectrometry, Fluorescence; Superoxides | 2009 |
Neuroprotective role of delta-opioid receptors against mitochondrial respiratory chain injury.
Topics: Animals; Blotting, Western; Cells, Cultured; Cerebral Cortex; Electron Transport; Electrophoresis, Polyacrylamide Gel; Enkephalin, Leucine-2-Alanine; Immunoprecipitation; L-Lactate Dehydrogenase; Mitochondria; Naltrexone; Narcotic Antagonists; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Sodium Azide | 2009 |
Role of opioid system in modulation of pain sensitivity under conditons of low and high environmental temperature.
Topics: Analgesics, Opioid; Animals; Cold Temperature; Hot Temperature; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Pain Threshold; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2008 |
Protection conferred by Corticotropin-releasing hormone in rat primary cortical neurons against chemical ischemia involves opioid receptor activation.
Topics: Animals; Brain Ischemia; Cell Death; Cells, Cultured; Corticotropin-Releasing Hormone; Dynorphins; Enkephalins; Indoles; Naltrexone; Narcotic Antagonists; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Potassium Cyanide; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone; Receptors, Opioid, delta; Receptors, Opioid, kappa; RNA, Messenger | 2009 |
Evidence for the involvement of the opioid system in the antidepressant-like effect of folic acid in the mouse forced swimming test.
Topics: Analgesics, Opioid; Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Disease Models, Animal; Dizocilpine Maleate; Drug Combinations; Excitatory Amino Acid Antagonists; Exploratory Behavior; Folic Acid; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Swimming | 2009 |
Design and synthesis of novel delta opioid receptor agonists and their pharmacologies.
Topics: Drug Design; Morphinans; Naltrexone; Receptors, Opioid, delta | 2009 |
Opioid, cannabinoid CB1 and NOP receptors do not mediate APAP-induced hypothermia in rats.
Topics: Acetaminophen; Aminoquinolines; Animals; Benzamides; Body Temperature; Hypothermia, Induced; Male; Naltrexone; Nociceptin Receptor; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Opioid; Rimonabant | 2009 |
Selective mu- and kappa-opioid receptor antagonists administered into the nucleus accumbens interfere with rapid tolerance to ethanol in rats.
Topics: Animals; Drug Tolerance; Ethanol; Male; Microinjections; Naloxone; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Rats; Rats, Wistar; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2009 |
Modulation of MDMA-induced behavioral and transcriptional effects by the delta opioid antagonist naltrindole in mice.
Topics: Amphetamine-Related Disorders; Animals; Behavior, Animal; Brain; Choice Behavior; Conditioning, Classical; Enkephalins; Gene Expression; Hallucinogens; Mice; Motor Activity; N-Methyl-3,4-methylenedioxyamphetamine; Naltrexone; Narcotic Antagonists; Pro-Opiomelanocortin; Protein Precursors; Receptors, Opioid, delta; RNA, Messenger; Social Environment; Transcription, Genetic | 2009 |
Role of the opioid system in incentive downshift situations.
Topics: Analgesics, Opioid; Animals; Conditioning, Classical; Dietary Sucrose; Drinking Behavior; Enkephalin, D-Penicillamine (2,5)-; Extinction, Psychological; Feeding Behavior; Female; Goals; Male; Motivation; Naloxone; Naltrexone; Narcotic Antagonists; Random Allocation; Rats; Rats, Long-Evans; Receptors, Opioid, mu; Taste Perception; Time Factors | 2009 |
The antinociceptive properties of reboxetine in acute pain.
Topics: Adrenergic Antagonists; Analgesics; Animals; Antidepressive Agents; Clonidine; Disease Models, Animal; Drug Interactions; Male; Mice; Mice, Inbred ICR; Morphine; Morpholines; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Reboxetine; Receptors, Opioid, mu | 2009 |
Lack of effect of naltrindole on the spinal synergism of morphine and non-steroidal anti-inflammatory drugs (NSAIDS).
Topics: Analgesics, Opioid; Animals; Cyclooxygenase Inhibitors; Drug Synergism; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Morphine; Naltrexone; Pain; Receptors, Opioid, delta; Spinal Cord | 2009 |
Delta opioid agonist [D-Ala2, D-Leu5] enkephalin (DADLE) reduced oxygen-glucose deprivation caused neuronal injury through the MAPK pathway.
Topics: Animals; Brain Injuries; Cell Hypoxia; Cell Survival; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Enkephalin, Leucine-2-Alanine; Extracellular Signal-Regulated MAP Kinases; Glucose; JNK Mitogen-Activated Protein Kinases; L-Lactate Dehydrogenase; MAP Kinase Signaling System; Naltrexone; Narcotic Antagonists; Neurons; Neuroprotective Agents; p38 Mitogen-Activated Protein Kinases; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta | 2009 |
The peripheral administration of a nitric oxide donor potentiates the local antinociceptive effects of a DOR agonist during chronic inflammatory pain in mice.
Topics: Analgesics, Opioid; Animals; Chronic Disease; Disease Models, Animal; Drug Therapy, Combination; Enkephalin, D-Penicillamine (2,5)-; Freund's Adjuvant; Hot Temperature; Hyperalgesia; Inflammation; Male; Mice; Mice, Inbred C57BL; Naltrexone; Narcotic Antagonists; Nitric Oxide; Nitric Oxide Donors; Nitroso Compounds; Pain Measurement; Receptors, Opioid, delta; Time Factors | 2009 |
Opioid antagonists block the acquisition of ethanol-mediated conditioned tactile preference in infant rats.
Topics: Alcohol Drinking; Alcoholic Intoxication; Animals; Animals, Newborn; Conditioning, Classical; Ethanol; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Touch | 2009 |
Roles of opioid receptor subtypes in mediating alcohol-seeking induced by discrete cues and context.
Topics: Analysis of Variance; Animals; Behavior, Addictive; Behavior, Animal; Conditioning, Operant; Cues; Dose-Response Relationship, Drug; Environment; Ethanol; Extinction, Psychological; Injections, Intraventricular; Male; Motor Activity; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Self Administration; Somatostatin | 2009 |
The novel delta opioid receptor agonist UFP-512 dually modulates motor activity in hemiparkinsonian rats via control of the nigro-thalamic pathway.
Topics: Amino Acids; Animals; Antiparkinson Agents; Benzimidazoles; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Globus Pallidus; Glutamic Acid; Male; Motor Activity; Naltrexone; Narcotic Antagonists; Neural Pathways; Oligopeptides; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Substantia Nigra; Thalamus | 2009 |
Association of increased pain threshold by noise with central opioid neurons.
Topics: Analgesia; Animals; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Noise; Opioid Peptides; Pain Measurement; Pain Threshold; Receptors, Opioid, delta; Receptors, Opioid, mu; Stress, Physiological | 2009 |
Chronic treatment with agonists of beta(2)-adrenergic receptors in neuropathic pain.
Topics: Adrenergic beta-2 Receptor Agonists; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Functional Laterality; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Naltrexone; Narcotic Antagonists; Pain Measurement; Pain Threshold; Propanolamines; Receptors, Adrenergic, beta-2; Sciatica; Time Factors | 2010 |
Acute methadone treatment reduces myocardial infarct size via the delta-opioid receptor in rats during reperfusion.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Male; Methadone; Morphine; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Time Factors | 2009 |
Remifentanil post-conditioning attenuates cardiac ischemia-reperfusion injury via kappa or delta opioid receptor activation.
Topics: Analgesics, Opioid; Animals; Blood Pressure; Cardiotonic Agents; Dose-Response Relationship, Drug; Heart Rate; In Vitro Techniques; Ischemic Preconditioning, Myocardial; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Naltrexone; Narcotic Antagonists; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Remifentanil; Somatostatin | 2010 |
Antinociceptive effects of galanin in the central nucleus of amygdala of rats, an involvement of opioid receptors.
Topics: Amygdala; Animals; Galanin; Hindlimb; Hot Temperature; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Physical Stimulation; Rats; Rats, Wistar; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Time Factors | 2010 |
Mu-opioid receptors are not necessary for nortriptyline treatment of neuropathic allodynia.
Topics: Adrenergic Uptake Inhibitors; Analysis of Variance; Animals; Male; Mice; Mice, Knockout; Morphine; Naltrexone; Narcotic Antagonists; Neuralgia; Nortriptyline; Pain Measurement; Receptors, Opioid, mu | 2010 |
A GPCR/secretase complex regulates beta- and gamma-secretase specificity for Abeta production and contributes to AD pathogenesis.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Carbamates; Cells, Cultured; Dipeptides; Enkephalin, Leucine-2-Alanine; Humans; Mice; Mice, Inbred C57BL; Mice, Transgenic; Multiprotein Complexes; Naltrexone; Narcotic Antagonists; Protein Transport; Receptors, G-Protein-Coupled; Receptors, Opioid, delta; Substrate Specificity; Transport Vesicles | 2010 |
Nucleus accumbens mu opioid receptors mediate immediate postictal decrease in locomotion after an amygdaloid kindled seizure in rats.
Topics: Amygdala; Animals; Epilepsy; Kindling, Neurologic; Locomotion; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Rats; Rats, Long-Evans; Receptors, Opioid, mu; Seizures | 2010 |
Involvement of the kappa-opioid receptor in nitrous oxide-induced analgesia in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics, Non-Narcotic; Animals; Benzamides; Male; Mice; Mice, Inbred C57BL; Naltrexone; Narcotic Antagonists; Nitrous Oxide; Pain; Piperazines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Treatment Outcome | 2010 |
Effects of intracerebroventricular application of the delta opioid receptor agonist [D-Ala2, D-Leu5] enkephalin on neurological recovery following asphyxial cardiac arrest in rats.
Topics: Animals; Asphyxia; CA1 Region, Hippocampal; Cell Survival; Enkephalin, Leucine-2-Alanine; Heart Arrest; Injections, Intraventricular; Male; Maze Learning; Naltrexone; Neurons; Neuroprotective Agents; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta | 2010 |
Evidence for a role of opioids in epoxyeicosatrienoic acid-induced cardioprotection in rat hearts.
Topics: 8,11,14-Eicosatrienoic Acid; Analgesics, Opioid; Animals; Disease Models, Animal; GTP-Binding Protein alpha Subunits, Gi-Go; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Somatostatin | 2010 |
Alteration of intravenous nicotine self-administration by opioid receptor agonist and antagonists in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Dose-Response Relationship, Drug; Feeding Behavior; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nicotine; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Self Administration; Tobacco Use Disorder | 2010 |
Ex vivo delta opioid receptor autoradiography: CNS receptor occupancy of two novel compounds over their antihyperalgesic dose range.
Topics: Analgesics, Opioid; Animals; Autoradiography; Azabicyclo Compounds; Corpus Striatum; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Guanosine 5'-O-(3-Thiotriphosphate); Lumbar Vertebrae; Male; Naltrexone; Pain Measurement; Pyrimidines; Pyrrolidines; Radiography; Radioligand Assay; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord; Xanthenes | 2010 |
Delta opioid receptor on equine sperm cells: subcellular localization and involvement in sperm motility analyzed by computer assisted sperm analyzer (CASA).
Topics: Animals; Cell Survival; Enkephalin, D-Penicillamine (2,5)-; Horses; Image Processing, Computer-Assisted; Male; Naltrexone; Receptors, Opioid, delta; Semen Analysis; Sperm Motility; Spermatozoa; Subcellular Fractions; Tissue Distribution | 2010 |
Influence of new deltorphin analogues on reinstatement of cocaine-induced conditioned place preference in rats.
Topics: Animals; Behavior, Addictive; Behavioral Research; Cocaine; Conditioning, Psychological; Infusions, Intraventricular; Maze Learning; Motor Activity; Naltrexone; Narcotic Antagonists; Oligopeptides; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Opioid, delta; Reward | 2010 |
A role for delta opioid receptors in the central nucleus of the amygdala in anxiety-like behaviors.
Topics: Amygdala; Analgesics, Opioid; Animals; Anxiety; Behavior, Animal; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Fear; Male; Microinjections; Motor Activity; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Swimming; Time Factors | 2010 |
Dark chocolate receptors: epicatechin-induced cardiac protection is dependent on delta-opioid receptor stimulation.
Topics: Animals; Cacao; Catechin; Decanoic Acids; Dose-Response Relationship, Drug; Hydroxy Acids; Male; Mice; Mice, Inbred C57BL; Models, Animal; Myocardial Infarction; Myocardial Reperfusion Injury; Naloxone; Naltrexone; Potassium Channel Blockers; Receptors, Cell Surface; Receptors, Opioid, delta | 2010 |
Acupuncture inhibits GABA neuron activity in the ventral tegmental area and reduces ethanol self-administration.
Topics: Action Potentials; Acupuncture Therapy; Animals; Drug Interactions; Electric Stimulation; Ethanol; gamma-Aminobutyric Acid; Male; Naloxone; Naltrexone; Neurons; Rats; Rats, Wistar; Self Administration; Sucrose; Tail; Ventral Tegmental Area | 2010 |
Dorsal hippocampal opioidergic system modulates anxiety-like behaviors in adult male Wistar rats.
Topics: Analgesics, Opioid; Animals; Anxiety; CA1 Region, Hippocampal; Disease Models, Animal; Enkephalin, D-Penicillamine (2,5)-; Male; Maze Learning; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu | 2010 |
μ-Opioid receptors in the nucleus accumbens shell region mediate the effects of amphetamine on inhibitory control but not impulsive choice.
Topics: Amphetamine; Analgesics, Opioid; Animals; Attention; Central Nervous System Stimulants; Choice Behavior; Conditioning, Operant; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Impulsive Behavior; Inhibition, Psychological; Male; Motivation; Naloxone; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Peptides; Rats; Rats, Wistar; Reaction Time; Receptors, Opioid, mu; Reinforcement Schedule | 2011 |
Morphine postconditioning attenuates ICAM-1 expression on endothelial cells.
Topics: Animals; Benzophenanthridines; Endothelial Cells; Endothelium, Vascular; Humans; Intercellular Adhesion Molecule-1; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Protein Isoforms; Protein Kinase C; Receptors, Opioid; Reperfusion Injury; Signal Transduction; Umbilical Veins | 2011 |
Brain P450 epoxygenase activity is required for the antinociceptive effects of improgan, a nonopioid analgesic.
Topics: 14-alpha Demethylase Inhibitors; Amides; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Brain; Cell Line, Transformed; Cimetidine; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Humans; Imidazoles; Injections, Intraventricular; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Miconazole; NADPH-Ferrihemoprotein Reductase; Naltrexone; Narcotic Antagonists; Pain Measurement; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Histamine H3; Sulfides; Time Factors; Tritium | 2011 |
Nucleus accumbens facilitates nociception.
Topics: Analysis of Variance; Animals; Electrodes, Implanted; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Injections, Spinal; Lidocaine; Male; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Pain; Pain Measurement; Pain Perception; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Somatostatin; Spinal Cord | 2011 |
Multiple opioid receptors mediate the hypotensive response induced by central 5-HT(3) receptor stimulation.
Topics: Animals; Biguanides; Blood Pressure; Heart Rate; Hypotension; Male; Naloxone; Naltrexone; Narcotic Antagonists; Ondansetron; Rats; Rats, Wistar; Receptors, Opioid; Receptors, Serotonin, 5-HT3; Serotonin 5-HT3 Receptor Agonists; Serotonin 5-HT3 Receptor Antagonists | 2011 |
The novel δ opioid receptor agonist KNT-127 produces antidepressant-like and antinociceptive effects in mice without producing convulsions.
Topics: Analgesics; Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Behavior, Animal; Benzamides; Depression; Dopamine Antagonists; Imipramine; Male; Mice; Mice, Inbred ICR; Morphinans; Motor Activity; Naltrexone; Narcotic Antagonists; Pain Measurement; Piperazines; Receptors, Opioid, delta; Seizures; Swimming | 2011 |
Synergism between dexketoprofen and meloxicam in an orofacial formalin test was not modified by opioid antagonists.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Facial Pain; Formaldehyde; Ketoprofen; Male; Meloxicam; Mice; Naltrexone; Narcotic Antagonists; Stereoisomerism; Thiazines; Thiazoles | 2011 |
Involvement of the opioid system in the orexigenic and hedonic effects of melanin-concentrating hormone.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Eating; Hypothalamic Hormones; Injections, Intraventricular; Male; Melanins; Models, Animal; Naltrexone; Narcotic Antagonists; Pituitary Hormones; Rats; Rats, Wistar; Receptors, Opioid; Sucrose; Taste | 2011 |
The effects of opioid receptor antagonists on electroacupuncture-produced anti-allodynia/hyperalgesia in rats with paclitaxel-evoked peripheral neuropathy.
Topics: Analysis of Variance; Animals; Antineoplastic Agents, Phytogenic; Disease Models, Animal; Electroacupuncture; Hyperalgesia; Male; Naltrexone; Narcotic Antagonists; Paclitaxel; Pain Measurement; Pain Threshold; Peripheral Nervous System Diseases; Random Allocation; Rats; Rats, Sprague-Dawley; Somatostatin | 2011 |
Activation of the δ-opioid receptor inhibits serum deprivation-induced apoptosis of human liver cells via the activation of PKC and the mitochondrial pathway.
Topics: Apoptosis; bcl-2-Associated X Protein; Cytochromes c; Enkephalin, Leucine-2-Alanine; Gene Expression; Hepatocytes; Humans; Liver; Liver Diseases; Membrane Potential, Mitochondrial; Mitochondria; Naltrexone; Protein Kinase C; Proto-Oncogene Proteins c-bcl-2; Receptors, Opioid, delta; Serum; Signal Transduction; Stress, Physiological; Tumor Cells, Cultured | 2011 |
Opioidergic modulation of ethanol self-administration in the ventral pallidum.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Alcohol Drinking; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Globus Pallidus; Male; Microinjections; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Self Administration; Somatostatin | 2012 |
Opioid-like antinociceptive effects of oral administration of a lectin purified from the seeds of Canavalia brasiliensis.
Topics: Administration, Oral; Analgesics; Analgesics, Opioid; Animals; Canavalia; Mice; Morphinans; Naloxone; Naltrexone; Nociception; Pain Measurement; Plant Lectins; Receptors, Opioid, delta; Receptors, Opioid, kappa; Seeds | 2013 |
Dorsal hippocampal N-methyl-D-aspartate glutamatergic and δ-opioidergic systems modulate anxiety behaviors in rats in a noninteractive manner.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; CA1 Region, Hippocampal; Enkephalin, D-Penicillamine (2,5)-; Male; Maze Learning; Motor Activity; Naltrexone; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, delta | 2011 |
Neuroprotective effects of remifentanil against transient focal cerebral ischemia in rats.
Topics: Anesthetics, Intravenous; Animals; Blood Pressure; Blotting, Western; Carbon Dioxide; Dose-Response Relationship, Drug; Infarction, Middle Cerebral Artery; Interleukin-6; Ischemic Attack, Transient; Male; Mitogen-Activated Protein Kinases; Naltrexone; Narcotic Antagonists; Nervous System Diseases; Neuroprotective Agents; Piperidines; Rats; Rats, Sprague-Dawley; Remifentanil; Reperfusion Injury; Tumor Necrosis Factor-alpha | 2012 |
Sensitivity to μ-opioid receptor-mediated anti-nociception is determined by cross-regulation between μ- and δ-opioid receptors at supraspinal level.
Topics: Analgesics, Opioid; Animals; Brain; Cyclic AMP; Disease Models, Animal; Guanosine 5'-O-(3-Thiotriphosphate); Immunoprecipitation; Male; Naltrexone; Narcotic Antagonists; Pain; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptor Cross-Talk; Receptors, Opioid, delta; Receptors, Opioid, mu; Species Specificity; Spinal Cord | 2012 |
Delta-opioid receptor activation promotes mesenchymal stem cell survival via PKC/STAT3 signaling pathway.
Topics: Animals; Benzamides; Cell Survival; Cells, Cultured; Dactinomycin; Male; Mesenchymal Stem Cells; Models, Animal; Myeloid Cell Leukemia Sequence 1 Protein; Naltrexone; Piperazines; Protein Kinase C; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Inbred F344; Receptors, Opioid, delta; Signal Transduction; STAT3 Transcription Factor | 2012 |
YFa and analogs: investigation of opioid receptors in smooth muscle contraction.
Topics: Acetylcholine; Analgesics, Opioid; Animals; Cholinergic Agonists; Dynorphins; Enkephalin, Methionine; Guinea Pigs; Ileum; Male; Mice; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists; Neurotransmitter Agents; Oligopeptides; Receptors, Opioid; Vas Deferens | 2011 |
Delta opioid receptors contribute to the cardiorespiratory effects of biphalin in anesthetized rats.
Topics: Analgesics; Animals; Cardiovascular System; Enkephalins; Injections, Intravenous; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid, delta; Respiratory System | 2011 |
Hypoxic preconditioning attenuates global cerebral ischemic injury following asphyxial cardiac arrest through regulation of delta opioid receptor system.
Topics: Animals; Apoptosis; Arousal; Asphyxia; Behavior, Animal; Blotting, Western; Brain Ischemia; Brain Stem; Enkephalin, Leucine; Fluorescent Antibody Technique; Heart Arrest; Hypoxia-Inducible Factor 1, alpha Subunit; Hypoxia, Brain; In Situ Nick-End Labeling; Ischemic Preconditioning; Male; Motor Activity; Naltrexone; Narcotic Antagonists; Postural Balance; Rats; Real-Time Polymerase Chain Reaction; Receptors, Opioid, delta; RNA, Small Interfering; Seizures; Survival Analysis | 2012 |
The relationship between naloxone-induced cortisol and delta opioid receptor availability in mesolimbic structures is disrupted in alcohol-dependent subjects.
Topics: Adrenocorticotropic Hormone; Adult; Alcoholism; Area Under Curve; Case-Control Studies; Dose-Response Relationship, Drug; Female; Humans; Hydrocortisone; Hypothalamo-Hypophyseal System; Ligands; Limbic System; Linear Models; Male; Middle Aged; Naloxone; Naltrexone; Narcotic Antagonists; Pituitary-Adrenal System; Positron-Emission Tomography; Receptors, Opioid, delta; Stress, Psychological; Young Adult | 2013 |
μ- and δ-opioid-related processes in the accumbens core and shell differentially mediate the influence of reward-guided and stimulus-guided decisions on choice.
Topics: Animals; Choice Behavior; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Naltrexone; Nucleus Accumbens; Peptide Fragments; Random Allocation; Rats; Rats, Long-Evans; Receptors, Opioid, delta; Receptors, Opioid, mu; Reward; Somatostatin | 2012 |
Endogenous opioid and cannabinoid mechanisms are involved in the analgesic effects of celecoxib in the central nervous system.
Topics: Analgesics; Animals; Carrageenan; Celecoxib; Central Nervous System; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Inflammation; Male; Naltrexone; Pain; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Opioid, delta; Receptors, Opioid, mu; Sulfonamides | 2012 |
δ-opioid receptor function in the dorsal striatum plays a role in high levels of ethanol consumption in rats.
Topics: Age Factors; Alcohol Drinking; Analgesia; Animals; Corpus Striatum; Drug Synergism; Ethanol; Guanosine 5'-O-(3-Thiotriphosphate); Male; Microinjections; Naltrexone; Quinolines; Radioligand Assay; Rats; Rats, Long-Evans; Receptors, Opioid, delta; Sulfur Radioisotopes | 2012 |
Naltrindole inhibits human multiple myeloma cell proliferation in vitro and in a murine xenograft model in vivo.
Topics: Animals; Antineoplastic Agents; Binding Sites; Bone Marrow; Cell Line, Tumor; Cell Proliferation; Extracellular Signal-Regulated MAP Kinases; HEK293 Cells; Humans; Mice; Mice, SCID; Multiple Myeloma; Naltrexone; Phosphorylation; Proto-Oncogene Proteins c-akt; Receptors, Opioid; Xenograft Model Antitumor Assays | 2012 |
Structural biology: How opioid drugs bind to receptors.
Topics: Animals; Biomimetic Materials; Humans; Morphinans; Naltrexone; Nociceptin Receptor; Opioid Peptides; Piperidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spiro Compounds; Tetrahydroisoquinolines | 2012 |
Structure of the δ-opioid receptor bound to naltrindole.
Topics: Amino Acid Sequence; Animals; Binding Sites; Conserved Sequence; Crystallography, X-Ray; Mice; Models, Molecular; Molecular Sequence Data; Naltrexone; Protein Structure, Tertiary; Receptors, Opioid, delta; Reproducibility of Results; Structure-Activity Relationship; Substrate Specificity | 2012 |
Novel object recognition as a facile behavior test for evaluating drug effects in AβPP/PS1 Alzheimer's disease mouse model.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Disease Models, Animal; Donepezil; Drug Evaluation, Preclinical; Female; Humans; Indans; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Transgenic; Naltrexone; Pattern Recognition, Visual; Piperidines; Presenilin-1; Random Allocation | 2012 |
Antinociceptive properties of Micrurus lemniscatus venom.
Topics: Administration, Oral; Analgesics; Animals; Elapid Venoms; Elapidae; Male; Mice; Morphine; Naltrexone; Pain; Pain Measurement; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 2012 |
Analgesic properties of chimeric peptide based on morphiceptin and PFRTic-amide.
Topics: Analgesia; Analgesics, Opioid; Animals; Arginine; Dose-Response Relationship, Drug; Endorphins; Guinea Pigs; Male; Mice; Morphinans; Naloxone; Naltrexone; Neuropeptides; Opioid Peptides; Proline; Receptors, Neuropeptide; Tetrahydroisoquinolines; Time Factors | 2012 |
[DADLE suppresses the proliferation of human liver cancer HepG2 cells by activation of PKC pathway and elevates the sensitivity to cis-diammine dichloridoplatium].
Topics: Antineoplastic Agents; Cell Cycle; Cell Proliferation; Cisplatin; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Enkephalin, Leucine-2-Alanine; Hep G2 Cells; Humans; Naltrexone; Phosphorylation; Protein Kinase C; Receptors, Opioid, delta; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate | 2012 |
Clinically employed opioid analgesics produce antinociception via μ-δ opioid receptor heteromers in Rhesus monkeys.
Topics: Analgesics; Analgesics, Opioid; Animals; Calcium Signaling; Data Interpretation, Statistical; Female; Fentanyl; HEK293 Cells; Humans; Injections, Spinal; Macaca mulatta; Male; Methadone; Mice; Naltrexone; Narcotic Antagonists; Pain Measurement; Receptors, Opioid, delta; Receptors, Opioid, mu | 2012 |
Spinal cord stimulation reduces hypersensitivity through activation of opioid receptors in a frequency-dependent manner.
Topics: Analgesics, Opioid; Animals; Hyperalgesia; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Neuralgia; Pain Measurement; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Spinal Cord; Spinal Cord Stimulation | 2013 |
Antinociceptive action of isolated mitragynine from Mitragyna Speciosa through activation of opioid receptor system.
Topics: Analgesics; Animals; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Male; Mice; Mice, Inbred ICR; Mitragyna; Naloxone; Naltrexone; Narcotic Antagonists; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Opioid; Secologanin Tryptamine Alkaloids | 2012 |
In vivo and in vitro characterization of naltrindole-derived ligands at the κ-opioid receptor.
Topics: Analgesics; Animals; Anxiety; Behavior, Animal; Depression; Guinea Pigs; Ligands; Male; Mice; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2013 |
The cardiovascular effects of a chimeric opioid peptide based on morphiceptin and PFRTic-NH2.
Topics: Analgesics, Opioid; Animals; Blood Pressure; Bradycardia; Endorphins; Heart Rate; Hypotension; Injections, Intravenous; Injections, Intraventricular; Male; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; NG-Nitroarginine Methyl Ester; Rats; Rats, Wistar | 2013 |
Kappa-opioid receptors mediate the antidepressant-like activity of hesperidin in the mouse forced swimming test.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Hesperidin; Male; Mice; Naloxone; Naltrexone; Receptors, Opioid, kappa; Receptors, Purinergic P1; Swimming | 2013 |
Antinociceptive effects of two deltorphins analogs in the tail-immersion test in rats.
Topics: Analgesics, Opioid; Animals; Drug Synergism; Drug Tolerance; Male; Morphine; Naltrexone; Narcotic Antagonists; Nociception; Oligopeptides; Pain Measurement; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa | 2013 |
[Effect of opioid receptor blockade on antibody response and proliferative response under stress conditions].
Topics: Animals; Antibody Formation; B-Lymphocytes; Cell Proliferation; Immobilization; Immunity, Humoral; Lymphocyte Count; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Rotation; Spleen; Stress, Physiological | 2013 |
Rewarding effects of ethanol combined with low doses of morphine through dopamine D1 receptors.
Topics: Analgesics, Opioid; Animals; Benzazepines; Central Nervous System Depressants; Conditioning, Psychological; Dose-Response Relationship, Drug; Ethanol; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Reward | 2013 |
Co-activation of μ- and δ-opioid receptors elicits tolerance to morphine-induced ventilatory depression via generation of peroxynitrite.
Topics: Analysis of Variance; Animals; Antidotes; Drug Tolerance; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Penicillamine; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Respiratory Insufficiency; Time Factors | 2013 |
Effects of co-administration of intrathecal nociceptin/orphanin FQ and opioid antagonists on formalin-induced pain in rats.
Topics: Analgesics; Animals; Formaldehyde; Injections, Spinal; Male; Naltrexone; Narcotic Antagonists; Nociceptin; Opioid Peptides; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid | 2013 |
Role of the endogenous opioid system in modulation of urinary bladder activity by spinal nerve stimulation.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Electric Stimulation; Female; Morphine; Muscle Contraction; Naltrexone; Narcotic Antagonists; Neural Inhibition; Opioid Peptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Spinal Nerves; Time Factors; Urinary Bladder; Urination | 2013 |
Long-term antinociception by electroacupuncture is mediated via peripheral opioid receptors in free-moving rats with inflammatory hyperalgesia.
Topics: Acupuncture Analgesia; Acupuncture Points; Animals; Disease Models, Animal; Electroacupuncture; Freund's Adjuvant; Hyperalgesia; Inflammation; Male; Naloxone; Naltrexone; Pain Measurement; Rats; Rats, Wistar; Receptors, Opioid; Time | 2013 |
An immunocytochemical-derived correlate for evaluating the bridging of heteromeric mu-delta opioid protomers by bivalent ligands.
Topics: HEK293 Cells; Humans; Immobilized Nucleic Acids; Immunohistochemistry; Ligands; Microscopy, Confocal; Models, Biological; Naltrexone; Promoter Regions, Genetic; Receptors, Opioid, delta; Receptors, Opioid, mu | 2013 |
Identification of a new dengue virus inhibitor that targets the viral NS4B protein and restricts genomic RNA replication.
Topics: Aedes; Amino Acid Substitution; Animals; Antiviral Agents; Cell Line; Cricetinae; Dengue; Dengue Virus; Drug Resistance, Viral; HeLa Cells; Humans; Mutation; Naltrexone; Nucleic Acid Synthesis Inhibitors; Replicon; RNA, Viral; Small Molecule Libraries; Viral Nonstructural Proteins; Virus Replication | 2013 |
δ-Opioid receptor activation rescues the functional TrkB receptor and protects the brain from ischemia-reperfusion injury in the rat.
Topics: Activating Transcription Factor 1; Animals; Blotting, Western; Brain; Brain Ischemia; Brain-Derived Neurotrophic Factor; CD11b Antigen; Cerebrovascular Circulation; Cyclic AMP Response Element-Binding Protein; Infarction, Middle Cerebral Artery; Male; Naltrexone; Quinolines; Rats; Rats, Sprague-Dawley; Receptor, trkB; Receptors, Opioid, delta; Reperfusion Injury | 2013 |
The mesolimbic system participates in the naltrexone-induced reversal of sexual exhaustion: opposite effects of intra-VTA naltrexone administration on copulation of sexually experienced and sexually exhausted male rats.
Topics: Animals; Copulation; Dose-Response Relationship, Drug; Male; Motor Activity; Naltrexone; Narcotic Antagonists; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Reproduction; Satiation; Sexual Behavior, Animal; Ventral Tegmental Area | 2013 |
Different types of opioid receptors involved in the suppression of LH secretion in lactating sheep.
Topics: Animals; Female; Gene Expression Regulation; Guanidines; Lactation; Luteinizing Hormone; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Sheep | 2013 |
Involvement of delta and mu opioid receptors in the acute and sensitized locomotor action of cocaine in mice.
Topics: Animals; Cocaine; Humans; Mice; Motor Activity; Naltrexone; Oligopeptides; Pain Measurement; Receptors, Opioid, delta; Receptors, Opioid, mu | 2013 |
Mechanisms underlying the antinociceptive effect of mangiferin in the formalin test.
Topics: Analgesics; Animals; Capsaicin; Formaldehyde; Glyburide; Male; Naloxone; Naltrexone; NG-Nitroarginine Methyl Ester; Nociception; Quinoxalines; Rats; Rats, Wistar; Serotonin; Xanthones | 2013 |
Novel fentanyl-based dual μ/δ-opioid agonists for the treatment of acute and chronic pain.
Topics: Acute Pain; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chronic Pain; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Enkephalins; Fentanyl; Male; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu | 2013 |
Delta opioid receptor agonist BW373U86 attenuates post-resuscitation brain injury in a rat model of asphyxial cardiac arrest.
Topics: Animals; Asphyxia; Benzamides; Blotting, Western; Brain Damage, Chronic; Cardiopulmonary Resuscitation; CREB-Binding Protein; Disease Models, Animal; Heart Arrest; Immunoenzyme Techniques; Male; Naltrexone; Neuroprotective Agents; Piperazines; Rats, Sprague-Dawley | 2014 |
Antinociceptive activity of a synthetic oxopyrrolidine-based compound, ASH21374, and determination of its possible mechanisms.
Topics: Analgesics; Analgesics, Opioid; Animals; Aspirin; Capsaicin; Cyclic GMP; Glutamic Acid; Male; Mice; Mice, Inbred BALB C; Morphine; Motor Activity; Naloxone; Naltrexone; Nitric Oxide; Pyrrolidines; Rats, Sprague-Dawley; Receptors, Opioid | 2013 |
Mu opioid receptor antagonism in the nucleus accumbens shell blocks consumption of a preferred sucrose solution in an anticipatory contrast paradigm.
Topics: Animals; Anticipation, Psychological; Food Preferences; Learning; Male; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Random Allocation; Rats; Rats, Long-Evans; Receptors, Opioid, delta; Receptors, Opioid, mu; Sucrose | 2014 |
Molecular control of δ-opioid receptor signalling.
Topics: Allosteric Regulation; Allosteric Site; Arrestins; Asparagine; beta-Arrestins; Crystallography, X-Ray; Humans; Ligands; Models, Molecular; Mutagenesis, Site-Directed; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Signal Transduction; Sodium; Structure-Activity Relationship | 2014 |
Spinal ERK2 activation through δ2-opioid receptors contributes to nociceptive behavior induced by intrathecal injection of leucine-enkephalin.
Topics: Animals; Arginine; Behavior, Animal; Butadienes; Enkephalin, Leucine; Enzyme Activation; Glycopeptides; Injections, Spinal; Leucine; Male; Mice, Inbred Strains; Mitogen-Activated Protein Kinase 1; Naltrexone; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitriles; Nociception; Protease Inhibitors; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, delta; Spinal Cord | 2014 |
Blockade of central delta-opioid receptors inhibits salt appetite in sodium-depleted rats.
Topics: Animals; Appetite; Blood Pressure; Drinking Behavior; Injections, Intraventricular; Male; Motor Activity; Naltrexone; Narcotic Antagonists; Oligopeptides; Rats, Wistar; Receptors, Opioid, delta; Sodium; Sodium Chloride, Dietary | 2014 |
δ-Opioid receptor activation reduces α-synuclein overexpression and oligomer formation induced by MPP(+) and/or hypoxia.
Topics: alpha-Synuclein; Cell Survival; HEK293 Cells; Humans; Hypoxia, Brain; Membrane Potential, Mitochondrial; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta | 2014 |
Knockout subtraction autoradiography: a novel ex vivo method to detect heteromers finds sparse KOP receptor/DOP receptor heterodimerization in the brain.
Topics: Animals; Autoradiography; Benzomorphans; Brain; Gene Knockout Techniques; Male; Mice; Mice, Knockout; Naltrexone; Protein Multimerization; Protein Structure, Quaternary; Receptors, Opioid, delta; Receptors, Opioid, kappa; Subtraction Technique | 2014 |
Central antinociception induced by ketamine is mediated by endogenous opioids and μ- and δ-opioid receptors.
Topics: Aminopeptidases; Analgesics; Animals; Brain; Cinnamates; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hot Temperature; Ketamine; Leucine; Male; Mice; Morphine Derivatives; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptive Pain; Opioid Peptides; Pain Perception; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2014 |
Delta-opioid receptor blockade in the ventral pallidum increases perceived palatability and consumption of saccharin solution in rats.
Topics: Animals; Avoidance Learning; Basal Forebrain; Conditioning, Psychological; Dose-Response Relationship, Drug; Drinking; Eating; Male; Motor Activity; Naltrexone; Narcotic Antagonists; Rats, Wistar; Receptors, Opioid, delta; Saccharin; Taste Perception | 2014 |
δ-Opioid receptors in the accumbens shell mediate the influence of both excitatory and inhibitory predictions on choice.
Topics: Animals; Behavior, Animal; Choice Behavior; Green Fluorescent Proteins; Male; Mice, Inbred C57BL; Mice, Transgenic; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Rats, Long-Evans; Receptors, Opioid, delta | 2015 |
Effects of systemic opioid receptor ligands on ethanol- and sucrose seeking and drinking in alcohol-preferring (P) and Long Evans rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Behavior, Addictive; Behavior, Animal; Ethanol; Ligands; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Long-Evans; Receptors, Opioid; Sucrose | 2014 |
Opioid receptors in the prelimbic cortex modulate restraint stress-induced cardiovascular responses in the rat.
Topics: Animals; Arterial Pressure; Body Temperature; Cerebral Cortex; Dose-Response Relationship, Drug; Heart Rate; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats, Wistar; Receptors, Opioid; Restraint, Physical; Stress, Psychological; Tachycardia | 2014 |
Opioid modulation of prolactin secretion induced by stress during late pregnancy. Role of ovarian steroids.
Topics: Analgesics, Opioid; Animals; Estradiol; Female; Mifepristone; Naloxone; Naltrexone; Narcotic Antagonists; Ovary; Pregnancy; Progesterone; Prolactin; Rats; Rats, Wistar; Steroids; Tamoxifen | 2014 |
Anti-nociception mediated by a κ opioid receptor agonist is blocked by a δ receptor agonist.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Behavior, Animal; Benzamides; Diazepam; Etorphine; Female; Hot Temperature; Male; Mice, Inbred C57BL; Mice, Knockout; Naltrexone; Nociceptin Receptor; Nociception; Piperazines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stress, Psychological | 2015 |
δ-Opioid receptors up-regulate excitatory amino acid transporters in mouse astrocytes.
Topics: Animals; Astrocytes; Benzimidazoles; Cells, Cultured; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Excitatory Amino Acid Transporter 3; Mice, Inbred C57BL; Naltrexone; Narcotic Antagonists; Oligopeptides; Receptors, Opioid, delta; RNA, Small Interfering; Up-Regulation | 2014 |
Involvement of μ- and δ-opioid receptor function in the rewarding effect of (±)-pentazocine.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Conditioning, Psychological; Dose-Response Relationship, Drug; Isomerism; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Pain; Pentazocine; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Reward | 2015 |
Opposite effects of neuropeptide FF on central antinociception induced by endomorphin-1 and endomorphin-2 in mice.
Topics: Adamantane; Animals; Benzeneacetamides; Dipeptides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Injections, Intraventricular; Male; Mice; Naltrexone; Nociception; Oligopeptides; Pyrrolidines | 2014 |
κ-Opioid receptors are not necessary for the antidepressant treatment of neuropathic pain.
Topics: Animals; Antidepressive Agents, Tricyclic; Male; Mice, Inbred C57BL; Mice, Knockout; Naltrexone; Neuralgia; Nortriptyline; Receptors, Opioid, delta; Receptors, Opioid, kappa; Sciatic Nerve | 2015 |
Delta opioid receptors: the link between exercise and cardioprotection.
Topics: Animals; Cardiotonic Agents; Disease Models, Animal; Exercise Test; Heart; HSP72 Heat-Shock Proteins; Male; Myocardial Reperfusion Injury; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid, delta | 2014 |
The opioid system contributes to the acquisition of reinforcement for dietary fat but is not required for its maintenance.
Topics: Animals; Conditioning, Operant; Dietary Fats; Dopamine Antagonists; Dose-Response Relationship, Drug; Eating; Food Preferences; Habituation, Psychophysiologic; Male; Mice, Inbred BALB C; Naltrexone; Narcotic Antagonists; Random Allocation; Reinforcement, Psychology; Space Perception; Sulpiride | 2015 |
Inhibition of DOR prevents remifentanil induced postoperative hyperalgesia through regulating the trafficking and function of spinal NMDA receptors in vivo and in vitro.
Topics: Anesthetics, Intravenous; Animals; Disease Models, Animal; Hot Temperature; Hyperalgesia; Lumbar Vertebrae; Male; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain Threshold; Pain, Postoperative; Piperidines; Posterior Horn Cells; Random Allocation; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, delta; Remifentanil; Spinal Cord; Tissue Culture Techniques; Touch | 2015 |
The opioid system majorly contributes to preference for fat emulsions but not sucrose solutions in mice.
Topics: Administration, Oral; Animals; Behavior, Animal; Choice Behavior; Dietary Fats; Eating; Emulsions; Food Preferences; Male; Mice; Mice, Inbred BALB C; Naloxone; Naltrexone; Narcotic Antagonists; Phospholipids; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Soybean Oil; Sucrose | 2015 |
Cellular localization and adaptive changes of the cardiac delta opioid receptor system in an experimental model of heart failure in rats.
Topics: Adaptation, Physiological; Animals; Binding, Competitive; Calcium Channels, L-Type; Disease Models, Animal; Enkephalins; Heart Failure; Ligands; Male; Myocardium; Naltrexone; Protein Binding; Protein Precursors; Radioligand Assay; Rats, Wistar; Receptors, Opioid, delta; Ryanodine Receptor Calcium Release Channel; Stroke Volume; Ventricular Function, Left | 2016 |
Effects of β-endorphin on functional activity of mouse splenocytes under conditions of in vivo blockade of μ,δ-opioid receptors.
Topics: Animals; beta-Endorphin; Concanavalin A; Interferon-gamma; Interleukin-2; Interleukin-4; Male; Mice; Naloxone; Naltrexone; Receptors, Opioid, delta; Spleen | 2015 |
Implication of delta opioid receptor subtype 2 but not delta opioid receptor subtype 1 in the development of morphine analgesic tolerance in a rat model of chronic inflammatory pain.
Topics: Analgesics, Opioid; Animals; Benzylidene Compounds; Chronic Pain; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Tolerance; Freund's Adjuvant; Hindlimb; Inflammation; Male; Morphine; Naltrexone; Narcotic Antagonists; Rats, Sprague-Dawley; Receptors, Opioid, delta | 2015 |
Enkephalin analog, cyclo[N(ε),N(β)-carbonyl-D-Lys(2),Dap(5)] enkephalinamide (cUENK6), inhibits the ethanol withdrawal-induced anxiety-like behavior in rats.
Topics: Analgesics, Opioid; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Central Nervous System Depressants; Enkephalin, Leucine; Enkephalins; Ethanol; Morphine; Naltrexone; Narcotic Antagonists; Neurotransmitter Agents; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Substance Withdrawal Syndrome | 2015 |
Types of skin afferent fibers and spinal opioid receptors that contribute to touch-induced inhibition of heart rate changes evoked by noxious cutaneous heat stimulation.
Topics: Analgesics, Opioid; Animals; Heart Rate; Hot Temperature; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Pain Management; Rats, Wistar; Receptors, Opioid; Reflex; Skin; Spinal Cord; Touch | 2015 |
Primary afferent neurons express functional delta opioid receptors in inflamed skin.
Topics: Action Potentials; Analysis of Variance; Animals; Dose-Response Relationship, Drug; Electric Stimulation; Freund's Adjuvant; Inflammation; Male; Naltrexone; Narcotic Antagonists; Nerve Fibers; Neurons, Afferent; Oligopeptides; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Skin | 2015 |
Naltrindole derivatives with fluorinated ethyl substituents on the 17-nitrogen as δ opioid receptor inverse agonists.
Topics: Drug Inverse Agonism; Enkephalin, Leucine; Halogenation; Humans; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Recombinant Proteins | 2015 |
Opioid-dependent regulation of high and low fear responses in two inbred mouse strains.
Topics: Amygdala; Analgesics, Opioid; Animals; Behavior, Animal; Conditioning, Classical; Enkephalins; Fear; Gene Expression; Genetic Association Studies; Hippocampus; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Naltrexone; Protein Precursors; Random Allocation; Receptors, Opioid; Stress, Psychological | 2015 |
Mice Lacking GPR88 Show Motor Deficit, Improved Spatial Learning, and Low Anxiety Reversed by Delta Opioid Antagonist.
Topics: Amygdala; Animals; Anxiety; Corpus Striatum; Dendrites; Dopamine; Female; Hippocampus; Male; Mice, Inbred C57BL; Mice, Knockout; Movement Disorders; Naltrexone; Narcotic Antagonists; Receptors, G-Protein-Coupled; Receptors, Opioid, delta; Receptors, Opioid, mu; Serotonin; Spatial Learning | 2016 |
Role of µ, κ, and δ opioid receptors in tibial inhibition of bladder overactivity in cats.
Topics: Acetic Acid; Animals; Cats; Female; Male; Morphinans; Naloxone; Naltrexone; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tibial Nerve; Transcutaneous Electric Nerve Stimulation; Urinary Bladder, Overactive | 2015 |
Brain opioid and nociceptin receptors are involved in regulation of bombesin-induced activation of central sympatho-adrenomedullary outflow in the rat.
Topics: Adrenal Medulla; Animals; Bombesin; Brain; Catecholamines; Morphinans; Naloxone; Naltrexone; Nociceptin Receptor; Rats; Receptors, Opioid; Sympathetic Nervous System | 2016 |
δ-Opioid receptor (DOR) signaling and reactive oxygen species (ROS) mediate intermittent hypoxia induced protection of canine myocardium.
Topics: Acetylcysteine; Animals; Arrhythmias, Cardiac; Dogs; Female; Hematocrit; Hypoxia; Ischemic Preconditioning, Myocardial; Male; Myocardial Infarction; Myocardium; Naltrexone; Reactive Oxygen Species; Receptors, Opioid, delta | 2016 |
Unique action mechanisms of tramadol in global cerebral ischemia-induced mechanical allodynia.
Topics: Analgesics, Opioid; Animals; Brain Ischemia; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperalgesia; Male; Mice; Naltrexone; Narcotic Antagonists; Pain Measurement; Pain Threshold; Tramadol | 2016 |
Bi-directional interplay between proximal and distal inputs to CA2 pyramidal neurons.
Topics: Action Potentials; Animals; CA2 Region, Hippocampal; Electric Stimulation; Excitatory Postsynaptic Potentials; Mice; Naltrexone; Narcotic Antagonists; Neural Pathways; Neuronal Plasticity; Neurons, Afferent; Patch-Clamp Techniques; Pyramidal Cells; Receptors, Opioid, delta; Synapses | 2017 |
δ-Opioid receptors: Pivotal role in intermittent hypoxia-augmentation of cardiac parasympathetic control and plasticity.
Topics: Animals; Dogs; Enkephalin, Methionine; Heart Atria; Hypoxia; Microdialysis; Naltrexone; Narcotic Antagonists; Neuronal Plasticity; Norepinephrine; Receptors, Opioid, delta; Sinoatrial Node; Vagus Nerve | 2016 |
Involvement of delta opioid receptors in alcohol withdrawal-induced mechanical allodynia in male C57BL/6 mice.
Topics: Analgesics; Analgesics, Opioid; Animals; Ethanol; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Naltrexone; Narcotic Antagonists; Pain Management; Quinolines; Receptors, Opioid, delta; Receptors, Opioid, mu; Substance Withdrawal Syndrome | 2016 |
Opioid system mediated anti-nociceptive effect of agomelatine in mice.
Topics: Acetamides; Analgesics; Animals; Dose-Response Relationship, Drug; Injections, Intraventricular; Male; Mice; Motor Activity; Naloxone; Naltrexone; Pain; Pain Measurement; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Rotarod Performance Test | 2016 |
Opioid system contribution to the antidepressant-like action of m-trifluoromethyl-diphenyl diselenide in mice: A compound devoid of tolerance and withdrawal syndrome.
Topics: Analgesics, Opioid; Animals; Antidepressive Agents; Behavior, Animal; Depression; Depressive Disorder; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Organosilicon Compounds; Receptors, Opioid, kappa; Substance Withdrawal Syndrome; Swimming | 2017 |
Serotonin induces peripheral antinociception via the opioidergic system.
Topics: Analgesics; Animals; Cinnamates; Dinoprostone; Disease Models, Animal; Male; Mice; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Opioid Peptides; Pain; Receptors, Opioid; Serotonin | 2018 |
The non-peptidic δ-opioid receptor agonist Tan-67 mediates neuroprotection post-ischemically and is associated with altered amyloid precursor protein expression, maturation and processing in mice.
Topics: Amyloid beta-Protein Precursor; Animals; Brain Ischemia; Cerebral Cortex; Male; Mice, Inbred C57BL; Naltrexone; Narcotic Antagonists; Neurons; Neuroprotective Agents; Quinolines; Receptors, Opioid, delta; Stroke | 2018 |
SNC80 and naltrindole modulate voltage-dependent sodium, potassium and calcium channels via a putatively delta opioid receptor-independent mechanism.
Topics: Benzamides; Calcium Channels; Cell Line; Dose-Response Relationship, Drug; Electrophysiological Phenomena; Gene Expression Regulation; Ion Channels; Naltrexone; Neurons; Piperazines; Potassium Channels; Receptors, Opioid, delta; Sodium Channels | 2018 |
Role of mu, but not delta or kappa, opioid receptors in context-induced reinstatement of oxycodone seeking.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Conditioning, Operant; Male; Naltrexone; Narcotic Antagonists; Oxycodone; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2019 |
The Chemokine CCL4 (MIP-1β) Evokes Antinociceptive Effects in Mice: a Role for CD4
Topics: Analgesics; Animals; CD4-Positive T-Lymphocytes; Chemokine CCL4; Enkephalin, Methionine; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Nociception; Pain; Pain Measurement | 2019 |
Noradrenaline induces peripheral antinociception by endogenous opioid release.
Topics: Analgesics; Animals; Cinnamates; Dinoprostone; Dose-Response Relationship, Drug; Hyperalgesia; Leucine; Male; Morphine Derivatives; Naltrexone; Norepinephrine; Opioid Peptides; Pain Measurement; Prazosin; Propranolol; Rats; Yohimbine | 2018 |
Abuse liability and therapeutic potential of the Mitragyna speciosa (kratom) alkaloids mitragynine and 7-hydroxymitragynine.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Mitragyna; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Secologanin Tryptamine Alkaloids; Self Administration | 2019 |
Administration of a delta opioid receptor agonist KNT-127 to the basolateral amygdala has robust anxiolytic-like effects in rats.
Topics: Amygdala; Animals; Anti-Anxiety Agents; Anxiety; Anxiety Disorders; Basolateral Nuclear Complex; Fear; Learning; Male; Morphinans; Muscimol; Naltrexone; Rats; Rats, Wistar; Receptors, Opioid, delta | 2018 |
A delta opioid receptor agonist, KNT-127, in the prelimbic medial prefrontal cortex attenuates glial glutamate transporter blocker-induced anxiety-like behavior in mice.
Topics: Amino Acid Transport System X-AG; Animals; Anti-Anxiety Agents; Anxiety; Aspartic Acid; Drug Interactions; gamma-Aminobutyric Acid; Glutamic Acid; Male; Mice; Microinjections; Morphinans; Naltrexone; Prefrontal Cortex; Receptors, Opioid, delta | 2018 |
Antagonism of μ-opioid receptors reduces sensation seeking-like behavior in mice.
Topics: Animals; Appetitive Behavior; Brain; Conditioning, Operant; Dose-Response Relationship, Drug; Exploratory Behavior; Male; Mice, Inbred C57BL; Morphinans; Motivation; Motor Activity; Naltrexone; Narcotic Antagonists; Random Allocation; Receptors, Opioid; Receptors, Opioid, mu; Reward | 2019 |
The antihyperalgesic effect of docosahexaenoic acid in streptozotocin-induced neuropathic pain in the rat involves the opioidergic system.
Topics: Analgesics; Analgesics, Opioid; Animals; Diabetic Neuropathies; Docosahexaenoic Acids; Dose-Response Relationship, Drug; Gabapentin; Naloxone; Naltrexone; Rats; Rats, Wistar; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, sigma; Streptozocin | 2019 |
Possible involvement of the μ opioid receptor in the antinociception induced by sinomenine on formalin-induced nociceptive behavior in mice.
Topics: Administration, Oral; Analgesics; Animals; Dose-Response Relationship, Drug; Formaldehyde; Male; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morphinans; Naloxone; Naltrexone; Nociception; Receptors, Opioid, mu; Spinal Cord | 2019 |
Delta-opioid receptor antagonist naltrindole reduces oxycodone addiction and constipation in mice.
Topics: Analgesics; Animals; Constipation; Drug Tolerance; Male; Mice; Mice, Inbred C57BL; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Oxycodone; Receptors, Opioid, delta; Respiratory Insufficiency | 2019 |
Sex differences in kappa opioid receptor inhibition of latent postoperative pain sensitization in dorsal horn.
Topics: Animals; Benzamides; Extracellular Signal-Regulated MAP Kinases; Female; Hyperalgesia; Male; Mice, Inbred C57BL; Naltrexone; Pain, Postoperative; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sex Factors; Somatostatin; Spinal Cord Dorsal Horn | 2020 |
Selective agonists of the δ-opioid receptor, KNT-127 and SNC80, act differentially on extinction learning of contextual fear memory in mice.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Benzamides; Conditioning, Psychological; Extinction, Psychological; Fear; Learning; Male; Memory; Mice; Morphinans; Motor Activity; Naltrexone; Piperazines; Receptors, Opioid, delta | 2019 |
Peripheral antinociception induced by ketamine is mediated by the endogenous opioid system.
Topics: Analgesics; Animals; Cinnamates; Dinoprostone; Ketamine; Male; Mice; Morphine Derivatives; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Receptors, Opioid, delta; Receptors, Opioid, mu | 2019 |
Dipyrone is locally hydrolyzed to 4-methylaminoantipyrine and its antihyperalgesic effect depends on CB
Topics: Analgesics; Animals; Cannabinoid Receptor Antagonists; Carrageenan; Dipyrone; Hydrolysis; Hyperalgesia; Indoles; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats, Wistar; Receptor, Cannabinoid, CB2; Receptors, Opioid, kappa; Somatostatin | 2020 |
Delta and kappa opioid receptors on mouse sperm cells: Expression, localization and involvement on in vitro fertilization.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Blastocyst; Embryo, Mammalian; Embryonic Development; Enkephalin, D-Penicillamine (2,5)-; Fertilization in Vitro; Male; Mice; Naltrexone; Narcotic Antagonists; Oocytes; Receptors, Opioid, delta; Receptors, Opioid, kappa; Sperm Capacitation; Spermatozoa | 2020 |
Pharmacological Properties of
Topics: Animals; Behavior, Animal; Benzamides; Buprenorphine; Drug Partial Agonism; Mice; Naltrexone; Piperazines; Receptors, Opioid, delta | 2020 |
Alleviation of TGF-β1 induced tubular epithelial-mesenchymal transition via the δ-opioid receptor.
Topics: Actins; Animals; Benzimidazoles; Blotting, Western; Cadherins; Cell Line; Cell Movement; Cell Survival; Epithelial Cells; Epithelial-Mesenchymal Transition; Fibronectins; Kidney Tubules, Proximal; MAP Kinase Signaling System; Naltrexone; Oligopeptides; Rats; Receptors, Opioid, delta; Transforming Growth Factor beta1 | 2021 |
The possible role of nitric oxide in anti-convulsant effects of Naltrindole in seizure-induced by social isolation stress in male mice.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Hippocampus; Male; Mice; Naltrexone; Narcotic Antagonists; Nitric Oxide; Nitric Oxide Synthase Type I; Pentylenetetrazole; Receptors, Opioid, delta; Seizures; Signal Transduction; Social Isolation; Stress, Psychological | 2020 |
Effects of
Topics: Animals; CHO Cells; Cricetulus; Humans; Naltrexone; Receptors, Opioid, delta | 2020 |
The blockade of kappa opioid receptors exacerbates alveolar bone resorption in rats.
Topics: Alveolar Bone Loss; Animals; Bone Resorption; Cytokines; Disease Models, Animal; Male; Morphinans; Naltrexone; Narcotic Antagonists; Osteoblasts; Osteoclasts; Periodontitis; Rats; Rats, Wistar; Receptors, Opioid | 2020 |
A low pKa ligand inhibits cancer-associated pain in mice by activating peripheral mu-opioid receptors.
Topics: Analgesics, Opioid; Animals; Bone Neoplasms; Cancer Pain; Cell Line, Tumor; Fentanyl; Hydrogen-Ion Concentration; Hyperalgesia; Ligands; Male; Melanoma, Experimental; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Piperidines; Receptors, Opioid, mu | 2020 |
Delta-opioid receptor-mediated modulation of excitability of individual hippocampal neurons: mechanisms involved.
Topics: Action Potentials; Animals; Behavior, Animal; Benzamides; Calcium Channels; Female; Hippocampus; Naltrexone; Narcotic Antagonists; Neurons; Piperazines; Potassium Channels; Primary Cell Culture; Rats; Rats, Wistar; Receptors, Opioid, delta; Sodium Channels | 2021 |
Morphine attenuates neuroinflammation and blood-brain barrier disruption following traumatic brain injury through the opioidergic system.
Topics: Analgesics, Opioid; Animals; Blood-Brain Barrier; Brain; Brain Injuries, Traumatic; Disease Models, Animal; Male; Morphine; Naltrexone; Neuroinflammatory Diseases; Neuroprotective Agents; Rats; Rats, Wistar | 2021 |