naltrexone and naloxone

naltrexone has been researched along with naloxone in 1434 studies

Research

Studies (1,434)

TimeframeStudies, this research(%)All Research%
pre-1990657 (45.82)18.7374
1990's386 (26.92)18.2507
2000's222 (15.48)29.6817
2010's138 (9.62)24.3611
2020's31 (2.16)2.80

Authors

AuthorsStudies
Berkowitz, DS; Loew, GH1
Dasher, WE; Klein, P; Nelson, WL1
Klein, P; Nelson, WL2
Klein, P; Nelson, WL; Olsen, LD; Simon, EJ; Yao, YH1
Galzi, JL; Goeldner, M; Hirth, C; Ilien, B; Mejean, A; Meunier, JC; Mollereau, C1
Burkard, WP; Eggstein-Aeppli, L; Schmidhammer, H; Smith, CF1
Cheney, BV1
Hahn, EF; Pasternak, GW1
Alreja, BD; Larson, DL; Portoghese, PS1
Carling, RW; Kobylecki, RJ; Lane, AC; Lord, JA; Smith, CF1
Portoghese, PS; Takemori, AE4
Bousquet, AR; Howes, JF; Kotick, MP; Polazzi, JO1
Archer, S; Gillan, MG; Kosterlitz, HW; Osei-Gyimah, P1
Befort, K; Bloch, B; Charron, G; Gavériaux-Ruff, C; Kieffer, B; Lannes, B; Mattéi, MG; Matthes, H; Micheletti, G; Simonin, F1
Cantrell, BE; Gidda, JS; Johnson, BG; Leander, JD; Schoepp, DD; Zimmerman, DM1
Bell, GI; Chen, Y; Kong, H; Raynor, K; Reisine, T; Yasuda, K; Yu, L1
Bell, GI; Breder, CD; Kong, H; Raynor, K; Reisine, T; Takeda, J; Yasuda, K1
Cantrell, BE; Johnson, BG; Leander, JD; Mendelsohn, LG; Mitch, CH; Reel, JK; Snoddy, J; Zimmerman, DM1
Cantrell, BE; Johnson, BG; Leander, JD; Mendelsohn, LG; Mitch, CH; Reel, JK; Shaw, WN; Snoddy, JD; Takemori, AE; Wong, DT1
Adapa, ID; Auh, JS; Berzetei-Gurske, IP; Brandt, SR; Craymer, K; Farrington, L; Haggart, D; Kennedy, JM; O'Brien, A; Polgar, WE; Rodriguez, L; Schwartz, RW; Toll, L; White, A1
Strassburg, CP; Tukey, RH1
Topliss, JG; Yoshida, F1
Adkison, KK; Humphreys, JE; Mahar Doan, KM; Polli, JW; Serabjit-Singh, CJ; Shampine, LJ; Webster, LO; Wring, SA1
Chang, TK; Ensom, MH; Kiang, TK1
Belanger, S; DeHaven, RN; Dolle, RE; Goodman, AJ; Graczyk, TM; Herbertz, T; Le Bourdonnec, B; Michaut, M; Yap, GP; Ye, HF1
Belanger, S; DeHaven, RN; Dolle, RE; Goodman, AJ; Graczyk, TM; Le Bourdonnec, B; Seida, PR1
Hebbel, RP; Lunzer, MM; Portoghese, PS; Yekkirala, A1
Bidlack, JM; Knapp, BI; Neumeyer, JL; Peng, X1
Andricopulo, AD; Moda, TL; Montanari, CA1
Aceto, MD; Coop, A; Harris, LS; May, EL; Metcalf, MD; Traynor, JR; Woods, JH1
Lombardo, F; Obach, RS; Waters, NJ1
Bidlack, JM; Bu, Y; Cohen, DJ; Lou, R; Lu, Q; VanAlstine, MA; Wentland, MP1
Aschenbach, LC; Cassidy, MP; Chen, J; Dewey, WL; Gabra, BH; Li, G; Selley, DE; Stevens, DL; Westkaemper, RB; Zhang, Y1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Bittman, RW; Cheng, K; Dersch, CM; Jacobson, AE; Lee, YS; Rice, KC; Rothman, RB1
Burgman, M; Grinnell, S; Haselton, N; Majumdar, S; Ocampo, J; Pasternak, AR; Pasternak, GW1
Fujii, H; Hirayama, S; Koyano, K; Mochizuki, H; Nagase, H; Nakajima, M; Nakao, K; Nemoto, T; Wada, N; Watanabe, A1
Burgman, M; Grinnell, S; Haselton, N; Le Rouzic, V; Majumdar, S; Nagakura, K; Ocampo, J; Pan, YX; Pasternak, AR; Pasternak, GW; Polikar, L; Subrath, J1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Aschenbach, LC; Dewey, WL; Elbegdorj, O; Li, G; Scoggins, KL; Selley, DE; Stevens, DL; Yuan, Y; Zaidi, SA; Zhang, Y1
Coop, A; Cunningham, CW; Eddington, ND; Hassan, HE; Mercer, SL; Metcalf, MD; Rosicky, AD1
Briddon, SJ; Canals, M; Graham, B; Kellam, B; Scammells, PJ; Schembri, LS; Stoddart, LA1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Costa, E; Guidotti, A; Racagni, G; Zsilla, G1
Geller, I; Hartmann, RJ1
Capozza, RC; Schmitt, EE; Sendelbeck, LR1
Brodin, AF; Frank, SG1
Ahtee, L; Carlsson, A; Garcia-Sevilla, JA; Magnusson, T1
Carino, MA; Horita, A1
Resnick, RB; Volavka, J1
Greenstein, R; O'Brien, C1
Fishman, J; Foldes, FF; Hahn, EF; Ronai, AZ1
Caruso, TP; Larson, DL; Portoghese, PS; Takemori, AE3
Grabowski, J; Greenstein, R; McLellan, AT; O'Brien, CP; Ternes, J1
Julius, DA3
Ling, W1
Renault, PF2
Zimmering, S1
Ashcraft, SB; Bathala, MS; Batra, VK; Harrigan, SE; Jao, MY; Ludden, TM; Malspeis, L; McCarthy, DA; Morrison, BE; Reuning, RH; Sams, RA; Staubus, AE1
Aylsworth, CF; Hodson, CA; Meites, J1
Smith, JB2
Callahan, EJ; Glazer, M; Liberman, RP; Rawson, RA1
Mulé, SJ; Verebey, K2
Ellingboe, J; Kuehnle, J; Mello, NK; Mendelson, JH1
Grabowski, J; Greenstein, R; Long, M; O'Brien, CP; Steinberg-Donato, S; Ternes, J2
Calne, DB; Chase, TN; Eisler, T; Nutt, JG; Rosin, AJ1
Braude, M; Brockman, H; Brusick, D; Jagannath, D; Matheson, D1
Altman, JL; Meyer, RE; Mirin, SM1
Altman, JL; McNamee, HB; Meyer, RE; Mirin, SM3
Ary, M; Chesarek, W; Lomax, P; Sorensen, SM1
Terenius, L; Wahlstrom, A1
Goldstein, A2
Bell, J; Gilbert, P; Martin, W; Sloan, J; Thompson, J1
Julius, D1
Craviso, GL; Gascon, P; Musacchio, JM; Puig, MM1
Archer, S; Michne, WF1
Costa, E; Dill, RE1
Terenius, L2
Herz, A; Höllt, V1
Järbe, TU; Ohlin, GC1
Wikler, A2
Grandison, L; Guidotti, A1
Caruso, TP; Jiang, JB; Larson, DL; Portoghese, PS; Takemori, AE2
Abood, LG; Butler, M; MacNeil, M; Salem, N1
Bailey, B; Diaz, J; Frenk, H; Paul, L1
Akil, H; Barchas, JD; Berger, PA; Watson, SJ1
Martin, WR2
Greenstein, R; O'Brien, CP; Woody, GE1
Kestenbaum, RS; Resnick, RB; Thomas, MA; Washton, AM1
Willette, RE1
Ellingboe, J; Keuhnle, JC; Mello, NK; Mendelson, JH1
Frank, GB; Marwaha, J1
Bauman, J; Cho, D; Dornbush, R; James, B; Mallya, A; Pevnick, J; Reker, D; Volavka, J1
Iversen, LL; Reisine, TD; Rossor, M; Spokes, E; Yamamura, HI1
Mackay, AV1
Jukofsky, D; Mulé, SJ; Verebely, K1
Resnick, RB; Washton, AM1
Buchsbaum, MS; Bunney, WE; Davis, GC; van Kammen, DP1
Greenstein, R; O'Brien, CP; Ternes, J; Woody, GE1
Cicero, TJ; Meyer, ER; Schainker, BA1
Friesen, HG; Panerai, AE; Tannenbaum, GS1
Downs, DA; Harrigan, SE1
Kosterlitz, HW2
Katz, RJ1
Berkowitz, BA; Hynes, MD1
Järbe, TU; Loman, P; Swedberg, MD1
Baum, MJ; Myers, BM1
Kosterlitz, HW; Leslie, FM1
Fennessy, MR; Laska, FJ1
Bhargava, HN2
Amir, S; Amit, Z1
Gerber, N; Lynn, RK; Rodgers, RM; Taylor, SM2
Brahen, LS; Capone, T; Wojak, JC1
Amir, S; Amit, Z; Blair, R1
Lehman, TM; Peterson, GR; Pyati, P1
Frenk, H; Rosen, JB1
Harry, GJ; Rosecrans, JA1
Amir, S; Amit, Z; Galina, HZ1
Bajusz, S; Berzétei, I; Rónai, AZ1
Gilbert, PE; Martin, WR2
Cho, D; James, B; Mallya, A; Pevnick, J; Reker, D; Volavka, J1
Gellert, VF; Holtzman, SG1
Resnick, RB1
Gitlin, M; Rosenblatt, M1
Brodin, AF; Frank, SG; Kavaliunas, DR1
Hui, FW; Krikun, E; Smith, AA1
Misra, AL; Pontani, RB; Vadlamani, NL1
D'Mello, GD; Pilcher, CW; Stolerman, IP1
Brine, GA; Carroll, FI; Cone, EJ; Darwin, WD; Gorodetzky, CW; Welch, CD1
Blumberg, H; Ikeda, C1
Black, R; Hersch, RG; Lewis, DC; Mayer, J1
Järbe, TU1
Bondeson, VC; Brine, DR; Brine, GA; Carroll, FI; Welch, CD1
Brotman, R; Remine, DC; Suffet, F; Taleporos, E1
Brahen, LS; Capone, T; Heller, RC; Landy, HJ; Lewis, MJ; Linden, SL1
Charuvastra, VC; Jarvik, ME; Sideroff, SI1
Erickson, CK; Harris, RA1
Blatnick, RA; Lieberman, MM; Pace, NL; Parrish, RG; Wong, KC1
Charuvastra, VC; Gritz, ER; Jarvik, ME; Schlesinger, J; Shiffman, SM1
Landsberg, R; Taintor, Z; Wicks, N1
Howes, JF; Schwope, AD; Wise, DL3
Greenstein, R; Hanna, N; Mintz, J; O'Brien, C; Woody, G1
Arias, R; Callahan, E; Glazer, M; McCleave, B; Rawson, R1
Bradford, A; Dorrier, C; Golondzowski, O; Hurley, F1
Kaim, SC1
Gerwirtz, D; Hurzeler, M; Kleber, H1
Curran, S; Savage, C1
Blakis, M; Haas, N; Holmes, E; Ling, W; Litaker, M1
Keegan, J; Lavenduski, C; Schooff, K1
Crawford, J; De Gracia, C; Nelkupa, JV; Parwatikar, S1
Cooperstein, J; Harris, M; Hough, G; Kauders, F; Resnick, R; Thomas, M1
Brahen, L; Capone, T; Wiechert, V1
Black, R; Hersch, R; Lewis, D; Mayer, J1
Bathala, MS; Bhat, HB; Frank, SG; Ludden, TM; Malspeis, L; Morrison, BE; Reuning, RH; Sokoloski, TD1
Baggot, JD; Frank, SG; Ludden, TM; Malspeis, L; Reuning, RH; Sokoloski, TD1
Gehrmann, JE; Killam, KF1
Colombel, MC; Jacob, J; Tremblay, E1
Bathala, MS; Feller, DR; Ludden, TM; Malspeis, L; Morrison, BE; Reuning, RH1
Braude, MC; Morrison, JM1
Holtzman, SG; Shannon, HE1
Frank, S; Malspeis, L; Notari, RE; Reuning, RH1
Brocco, MJ; Killam, KF; Robinson, CA1
Bell, JA; Martin, WR1
Kestenbaum, RS; Poole, D; Resnick, RB; Washton, A1
Hollister, LE; Kasper, P; Schwin, RL1
Bhat, HB; Burce, GL; Sokoloski, T1
Hanson, RN; Jiang, JB; Portoghese, PS; Takemori, AE1
Kogan, MJ; Mule, SJ; Verebey, K1
Brahen, LS; Capone, T; Desiderio, D; Wiechert, V1
Gallant, DM; Mielke, DH1
Cash, C; King, LJ; Minnema, KH1
Bläsig, J; Herz, A; Höllt, V; Paschelke, G1
Ary, M; Lomax, P1
Mulé, SJ; Resnick, RB; Verebey, K; Volavka, J1
Foldes, FF; Knoll, J; Rich, J; Vizi, ES1
Kalkwarf, DR; Sullivan, MF1
Jhamandas, K; Sutak, M2
Malspeis, L; Sams, RA1
Brine, GA; Carroll, FI; Hart, CK; Kotchmar, DJ; Moreland, CG; Praskash, D1
Berkowitz, BA; Finck, AD; Ngai, SH1
Geller, I; Hartmann, RJ; Ross, D1
McNamee, HB; Meyer, RE; Mirin, SM1
Freedman, AM; Kestenbaum, RS; Resnick, RB; Volavka, J1
Amico, L; Landsberg, R; Plumb, M; Taintor, Z; Wicks, N1
Chen, RC; Ho, AK1
Aronoff, M; Hough, G; Kauders, F; Kestenbaum, R; Lonborg, G; Resnick, R; Washton, A1
Chedekel, MA; Mule, SJ; Rosenthal, D; Verebely, K1
Fishman, J; Hahn, EF; Norton, BI1
Dimaio, J; Nogrady, T1
Cicero, TJ; Meyer, ER; Michael, H; Wilcox, CE1
Greenstein, RA; Mintz, J; O'Brien, CP; Woody, GE1
Lewis, DC1
Schecter, A2
Kauders, F; Schecter, A1
Brahen, LS1
Kalkward, DR; Sullivan, MF1
Arnold, DL; Granchelli, FE; Nelsen, L; Sheth, SG; Sidman, KR; Steber, WD; Strong, P1
Thies, C1
DePace, A; Kogan, MJ; Mulé, SJ; Verebey, K1
Calesnick, B1
Chen, RP; Fishman, J; Gray, MI; Hahn, EF; Heilman, RD1
Berggren, A; Rubenson, A; Sillén, U1
Bourgoin, S; Cesselin, F; Collin, E; Ferhat, L; Hamon, M; Mantelet, S; Mauborgne, A1
Di Giulio, AM; Donadoni, ML; Finco, C; Germani, E; Gorio, A; Malosio, ML; Mantegazza, P; Tenconi, B1
al-Rodhan, NR; Kelly, PJ; Yaksh, TL1
Guillaumet, G; Jabbouri, S; Lazar, S; Maunier, JC; Noël-Hocquet, S; Ropars, C1
Benzel, EC; Fowler, MR; Khare, V1
Pinnock, RD2
Bourgoin, S; Cesselin, F; Collin, E; Ferhat, L; Hamon, M1
Robinson, SR; Smotherman, WP1
Broccardo, M; Improta, G2
Kamei, J; Kasuya, Y; Kawashima, N1
Holtzman, SG; Jones, DN1
Kamei, J; Kasuya, Y; Kawashima, N; Ohhashi, Y1
Dickenson, AH; Kalso, EA; McQuay, HJ; Sullivan, AF1
Dewey, WL; Smith, FL2
Barg, J; Belcheva, MM; Chuang, DM; Coscia, CJ; Gao, XM; Gloeckner, C1
Crook, TJ; Hill, RG; Kitchen, I1
Riley, AL; Smurthwaite, ST2
Bergasa, NV; Jones, EA1
Abood, LG; Hashmi, M; Lerner-Marmarosh, N; Manda, S1
Leyton, M; Stewart, J1
Bansinath, M; Puig, MM; Tang, CK; Turndorf, H; Warner, W1
Caudle, RM; Chavkin, C; Wagner, JJ1
Fujimoto, JM; Holmes, BB2
Kastin, AJ; Kersh, D; Wyatt, A; Zadina, JE1
Griffin, IJ; Jackson, HC; Nutt, DJ1
Katafuchi, T; Koizumi, K; Nagatomo, I1
Larson, AA; Mousseau, DD; Sun, X1
Kleber, HD; Kosten, TR; Morgan, C1
Barney, CC; Morrison, CM; Renkema, LA; Vergoth, C1
Fournié-Zaluski, MC; Noble, F; Roques, BP; Turcaud, S1
de Zwaan, M; Mitchell, JE1
Melzack, R; Plamondon, H; Vaccarino, AL1
Ho, IK; Hoskins, B; Jaw, SP; Makimura, M; Oh, KW2
Geter, B; Kautz, MA; Riley, AL; Smurthwaite, ST1
Holtzman, SG; Paronis, CA1
Bourgoin, S; Cesselin, F; Collin, E; Hamon, M; Mantelet, S1
Carboni, E; Di Chiara, G; Garau, L; Longoni, R; Melchiorri, P; Mulas, A; Spina, L1
Jackson, HC; Nutt, DJ1
Calenco-Choukroun, G; Daugé, V; Féger, J; Gacel, G; Roques, BP1
Chalmers, J; Drolet, G; Morilak, DA1
Isayama, T; McLaughlin, PJ; Zagon, IS1
Aleman, DO; Bak, TH; Carr, KD; Simon, EJ1
Kaneto, H; Kawasaki, K; Kobayashi, Y; Maeda, M; Shimokawa, K; Taguchi, T; Takahashi, M; Tokuyama, S; Watanabe, J; Yamamoto, Y1
Jang, Y; Yoburn, BC1
Botschev, C; Müller, N1
Bilotta, JM; Brackeen, MF; Feldman, PL; James, MK; Leighton, HJ; Schuster, SV1
Jessop, JJ; Taplits, MS1
Lu, CL; Shaikh, MB; Siegel, A1
Angelucci, F; Negri, L; Noviello, V1
Baumann, MH; Rabii, J1
Furuya, Y; Kaneko, T; Nakazawa, T; Yamatsu, K1
Shiotsu, G; Stein, L; Stevens, KE1
Gannon, RL; Terrian, DM1
Godin, C; Henry, JL; Rochford, J1
Duckles, SP; Li, YJ1
Bourgoin, S; Cesselin, F; Chantrel, D; Collin, E; Hamon, M; Mauborgne, A1
Amao, H; Aoki, S; Hokao, R; Saito, TR; Sugiyama, M; Takahashi, KW; Wakafuji, Y1
Bansinath, M; Goldfrank, LR; Shukla, VK; Turndorf, H1
Mahayni, H; Minor, JR1
Burks, TF; Davis, TP; Greene, DL; Hersh, LB; Hruby, VJ; Kramer, TH; Sharma, SD; Weber, SJ; Yamamura, HI1
Firman, JD; Volmert, RF1
Ayres, EA; Burks, TF; Fang, S; Hruby, VJ; Kramer, TH; Parkhurst, DN1
Fletcher, PJ1
Cappell, H; Lê, AD; Poulos, CX; Walker, MJ1
Pasternak, GW; Paul, D; Pick, CG1
Casati, O; De Filippi, G; Foresti, V; Scolari, N; Zubani, R1
Gold, MS; Liebeskind, JC; Morgan, MM; Stein, C1
Jacoby, HI; Martinez, RP; Raffa, RB; Schupsky, JJ1
Coen, KM; Corrigall, WA1
Bossut, DF; Huang, ZS; Mayer, DJ; Sun, SL1
Bossut, DF; Mayer, DJ1
Armario, A; Garvey, JS; Giralt, M; Hidalgo, J1
Lopez, J; Naujokat, P; Toledo-Pereyra, LH; Walters, W; Xavier, R2
Kirkham, TC1
Kaneto, H; Takahashi, M; Watanabe, J1
Hoffmann, P; Skarphedinsson, JO; Thorén, P1
Koehler, E; McLemore, GL; Rosella-Dampman, LM; Summy-Long, JY1
Kromer, W3
Brasch, H; Kaschube, M1
Lenz, K; Loimer, N; Presslich, O; Schmid, R1
Bilsky, EJ; Marglin, SH; Reid, LD1
Leander, JD; Mayer-Valkanover, K; Nussbaumer, C; Schmidhammer, H; Schmidt, C; Schoepp, DD; Schratz, A; Walla-Kugler, M1
Misawa, M; Suzuki, T1
Fukagawa, Y; Misawa, M; Nagase, H; Suzuki, T2
Bodnar, RJ; Islam, AK1
de Costa, BR; France, CP; Jacobson, AE; Rice, KC; Woods, JH1
Ling, W; Wesson, DR2
Członkowski, A; Herz, A; Parsons, CG; Stein, C1
Heijna, MH; Hogenboom, F; Mulder, AH; Padt, M; Portoghese, PS; Schoffelmeer, AN1
Song, ZH; Takemori, AE1
Fuentes, JA; Iglesias, T; Jiménez, I1
Leander, JD; Zimmerman, DM1
Herz, A; Parsons, CG1
Balfour, HH; Gekker, G; Peterson, PK; Portoghese, PS; Sannerud, K; Sharp, BM1
Ben-Zvi, Z; Hurwitz, A; Looney, G; Sullins, M1
Delle, M; Hoffmann, P; Thorén, P1
Lutfy, K; Sierra, V; Yoburn, BC1
Cowan, A; Murray, CW1
Fleshner, M; Thurston, CL; Watkins, LR1
Kamei, J; Kasuya, Y; Tanihara, H1
Sinclair, JD1
Charney, DS; Kleber, HD; Kosten, TR; Krystal, JH; Morgan, CH; Price, LH2
Canli, T; Cook, RG; Miczek, KA1
Goldberg, SR; Katz, JL; Schindler, CW; Su, TP; Wu, XZ1
Angel, L; Appelmans, N; Gioannini, TL; Koolpe, GA; Nelson, WL; Simon, EJ1
Archer, S; Corbett, AD; Kosterlitz, HW; McKnight, AT; Paterson, SJ; Seyed-Mozaffari, A; Ward, S1
Goodman, RR; Hahn, EF; Nishimura, S; Pasternak, GW1
Einarsson, M; Koman, A; Terenius, L1
Cherubini, E; North, RA; Tokimasa, T1
Sandman, CA1
Cheng, SW; North, WG; O'Connor, EF1
Murray, MJ; Offord, KP; Yaksh, TL1
Melzack, R; Tasker, RAR; Vaccarino, AL1
Kosenkova, NS; Poshivalov, VP1
Reid, RL; Vanvugt, DA; Webb, MY2
Calcagnetti, DJ; Fanselow, MS; Helmstetter, FJ1
Buckingham, JC; Cover, PO1
Belluzzi, JD; Stein, L; Trujillo, KA2
Kanda, A; Kimura, T; Koyanagawa, H; Musha, T; Satoh, S1
France, CP; Morse, WH1
Fiserová, M; Metys, J1
Gurll, NJ; Holaday, JW; Lechner, RB; Reynolds, DG1
Bak, TH; Carr, KD; Portoghese, PS; Simon, EJ1
Heyman, JS; Jiang, Q; Mosberg, HI; Porreca, F; Rothman, RB1
Ahmed, MS; Quarles, C; Schoof, T; Zhou, DH1
Evans, RG; Ludbrook, J; Van Leeuwen, AF1
Huidobro-Toro, JP; Li, CH; Valenzuela, R1
Bals-Kubik, R; Herz, A; Shippenberg, TS1
Candeletti, S; Cavicchini, E; Ferri, S; Spampinato, S1
Fujimoto, JM; Rady, JJ2
Albuquerque, EX; Madsen, BW1
Abdelhamid, EM; Archer, S; Koolpe, GA; Michael, J; Michael, M; Nelson, WL; Simon, EJ1
Chaumont, AJ; Kintz, P; Lugnier, AA; Mangin, P1
Barsan, WG; Bartlett, R; Bryan, C; Buncher, R; Danzl, DF; Ling, LJ; Seger, D1
Barrett, RP; Feinstein, C; Hole, WT1
Bardin, CW; Belhadj, H; de Besi, L; Thau, RB1
Castellano, C; Introini-Collison, IB; McGaugh, JL; Pavone, F1
DiBona, GF; Jones, SY; Kapusta, DR1
Field, EA; Kuhn, CM2
Gentle, MJ; Savory, CJ; Yeomans, MR1
Dunlap, CE; Rose, JC; Valego, NK1
Kotlińska, J; Langwiński, R1
Pasternak, GW; Recht, LD1
Liu-Chen, LY; Phillips, CA1
Kunos, G; Mosqueda-Garcia, R1
Bykov, V; Holaday, JW; Jacobson, AE; Lessor, RA; McLean, S; Rice, KC; Rothman, RB1
Duax, WL; Hua, DH; Kolb, VM1
Almeida, OF; Herz, A; Nikolarakis, KE; Webley, GE1
Bykov, V; Holaday, JW; Jacobson, AE; Long, JB; Rice, KC; Rothman, RB1
Landymore, KM; Wilkinson, M1
Frischknecht, HR; Siegfried, B1
Hayes, AG; Sheehan, MJ; Tyers, MB1
Di Chiara, G; Imperato, A1
Katoh, M; Kimura, T; Satoh, S1
Holtzman, SG3
Baskin, DS; Hosobuchi, Y; Kuroda, H; Lee, NM1
Baron, SA; Gintzler, AR; Testa, FM1
Martin, WR; Wettstein, JG1
O'Neill, KA; Valentino, D1
Bloom, FE; Chavkin, C1
Ding, XZ; Fan, SG; Han, JS1
Lipkowski, AW; Portoghese, PS; Takemori, AE1
McLean, S; Rothman, RB1
Laorden, ML; Miralles, FS; Puig, MM1
Egdahl, RH; Gerstein, L; Grasberger, R; McIntosh, TK; Palter, M; Vezina, R; Yeston, N1
Eskay, R; Kunos, G; Mosqueda-Garcia, R; Palkovits, M; Zamir, N1
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Baron, CA; Blinova, K; Johannesen, L; Patel, D; Randolph, AL; Ren, M; Sheng, J; Strauss, DG; Thiebaud, N; Tran, PN; Volpe, DA; Wu, M; Wu, WW1
Farnaghi, F; Gholami, N; Hassanian-Moghaddam, H; McDonald, R; Saberi, M; Zamani, N1
Jin, Z; Kim, K; Zhan, CG; Zhang, CH; Zheng, F1
Board, A; Guy, GP; Jones, CM1
Kim, SA; Kim, YJ; Lee, GJ; Oh, SB1
Cruz, JS; de Macedo, FHP; Duarte, IDG; Ferreira, RCM; Gonçalves, WA; Gualdron, M; Machado, FS; Mahecha, GAB; Perez, AC; Rezende, BM; Romero, TRL1
García, MC1
Amstislavskaya, TG; de Abreu, MS; Demin, KA; Galstyan, DS; Giacomini, ACVV; Kalueff, AV; Kolesnikova, TO; Petersen, EV; Strekalova, T; Zabegalov, KN1
Ballet, S; Bermudez, M; De Neve, J; Dumitrascuta, M; Spetea, M; Trovato, O; Wolber, G1
Hill, LG; Loera, LJ; Zagorski, CM1
Narayan, RJ; Papich, MG1
Asher, A; Board, A; Cremer, LJ; Guy, GP; Parker, EM; Schieber, L1
Daunert, S; Deo, S; Dikici, E; Peyravian, N; Sun, E; Toborek, M1
Chang, HF; Chang, YC; Chao, YS; Chen, CT; Ke, YY; Law, PY; Lin, SY; Loh, HH; Ou, LC; Shih, C; Tao, PL; Tien, YW; Ueng, SH; Xi, JH; Yeh, SH1
Eikemo, M; Frost, JJ; Haaker, J; Leknes, S; Trøstheim, M1
McKew, JC; Sadee, W1
DeGrado, JR; Dube, KM; Goodberlet, MZ; Habeeb, EA; Lupi, KE; Tran, LK1
Benéitez García, MC; Colmena Crespo, I; Díez-Orejas, RM; Gil-Alegre, ME; Girón Moreno, R; Goicoechea García, C; Martín Fontelles, MI; Sánchez-Robles, EM1
Barnett, ML; Chyn, D; Hardy, B; Huskamp, HA; Lewinson, T; Meara, E; Mehrotra, A; Morden, NE; Onsando, M1
Benito, A; Escamilla, I; Haro, G; Juan, N; Peñalva, C; Renau, J; Sánchez-Llorens, M1

Reviews

81 review(s) available for naltrexone and naloxone

ArticleYear
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
    Annual review of pharmacology and toxicology, 2000, Volume: 40

    Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic

2000
UDP-glucuronosyltransferases and clinical drug-drug interactions.
    Pharmacology & therapeutics, 2005, Volume: 106, Issue:1

    Topics: Clinical Trials as Topic; Drug Interactions; Enzyme Activation; Enzyme Induction; Glucuronides; Glucuronosyltransferase; Humans; Pharmaceutical Preparations; Pharmacogenetics; Polymorphism, Genetic

2005
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
NIDA's naltrexone research program.
    NIDA research monograph, 1976, Issue:9

    Topics: Clinical Trials as Topic; Conditioning, Psychological; Cyclazocine; Drug Evaluation; Euphoria; Heroin; Heroin Dependence; Humans; Naloxone; Naltrexone; Narcotic Antagonists; Research; Research Support as Topic; United States; United States Substance Abuse and Mental Health Services Administration

1976
Recent progress in research on narcotic antagonists.
    Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques, 1976, Volume: 20

    Topics: Animals; Benzomorphans; Chemical Phenomena; Chemistry; Cyclazocine; Humans; In Vitro Techniques; Models, Biological; Morphinans; Morphine Derivatives; Nalbuphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pentazocine; Receptors, Opioid; Structure-Activity Relationship; Substance-Related Disorders; Thebaine

1976
Some observations on the opiate peptides and schizophrenia.
    Archives of general psychiatry, 1979, Volume: 36, Issue:1

    Topics: Administration, Oral; Brain; Double-Blind Method; Endorphins; Forecasting; Humans; Naloxone; Naltrexone; Receptors, Opioid; Renal Dialysis; Schizophrenia

1979
Methadone maintenance and narcotic blocking drugs. Appendix.
    The International journal of the addictions, 1977, Volume: 12, Issue:7

    Topics: Administration, Oral; Cyclazocine; Drug Tolerance; Heroin Dependence; Humans; Injections, Subcutaneous; Methadone; Naloxone; Naltrexone; Narcotic Antagonists; Research; Substance Withdrawal Syndrome

1977
Clinical pharmacology of narcotic antagonists.
    Annals of the New York Academy of Sciences, 1978, Volume: 311

    Topics: Animals; Conditioning, Psychological; Humans; Naloxone; Naltrexone; Narcotic Antagonists; Recurrence; Substance Withdrawal Syndrome; Substance-Related Disorders

1978
Evolution of the National Academy of Sciences study of naltrexone.
    NIDA research monograph, 1976, Issue:9

    Topics: Academies and Institutes; Clinical Trials as Topic; Cyclazocine; Drug Evaluation; Heroin Dependence; Humans; Male; Naloxone; Naltrexone; Research Design; Research Support as Topic

1976
Preclinical toxicity studies of naltrexone.
    NIDA research monograph, 1976, Issue:9

    Topics: Administration, Oral; Animals; Body Weight; Colitis; Dogs; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Evaluation, Preclinical; Female; Fertility; Haplorhini; Injections, Subcutaneous; Lethal Dose 50; Male; Mice; Naloxone; Naltrexone; Rats; Reproduction; Rhinitis; Teratogens

1976
Opiate antagonists and eating behavior in humans: a review.
    Journal of clinical pharmacology, 1992, Volume: 32, Issue:12

    Topics: Appetite Depressants; Dose-Response Relationship, Drug; Eating; Feeding and Eating Disorders; Feeding Behavior; Female; Humans; Male; Naloxone; Naltrexone; Narcotic Antagonists; Obesity

1992
Drugs of abuse--opiates.
    The Western journal of medicine, 1990, Volume: 152, Issue:5

    Topics: Central Nervous System; Humans; Inactivation, Metabolic; Methadone; Naloxone; Naltrexone; Narcotics; Opioid-Related Disorders; Primary Health Care; Receptors, Opioid

1990
Opioid antagonists: structure activity relationships.
    NIDA research monograph, 1990, Volume: 96

    Topics: Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Structure-Activity Relationship

1990
Drug discrimination studies.
    Drug and alcohol dependence, 1985, Volume: 14, Issue:3-4

    Topics: Analgesics, Opioid; Animals; Columbidae; Discrimination, Psychological; Dose-Response Relationship, Drug; Fentanyl; Generalization, Stimulus; Macaca mulatta; Morphine; Nalorphine; Naloxone; Naltrexone; Pentazocine; Phenazocine; Phencyclidine; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu

1985
Behavioral significance of opioid peptides in relation to hippocampal function.
    NIDA research monograph, 1988, Volume: 82

    Topics: Animals; beta-Endorphin; Diprenorphine; Endorphins; Hippocampus; Learning; Memory; Naloxone; Naltrexone; Neurons, Afferent; Spatial Behavior

1988
[Enkephalinergic regulation of cardiovascular centers].
    Journal de pharmacologie, 1985, Volume: 16 Suppl 2

    Topics: Animals; Blood Pressure; Brain Mapping; Cardiovascular Physiological Phenomena; Cats; Dextromoramide; Dogs; Enkephalin, Methionine; Enkephalins; Heart Rate; Medulla Oblongata; Naloxone; Naltrexone; Nervous System Physiological Phenomena; Pressoreceptors; Rats; Receptors, Opioid; Reflex; Reticular Formation; Sympathetic Nervous System; Vagus Nerve; Vasomotor System

1985
Neurochemical correlates of opiate receptor regulation.
    Biochemical pharmacology, 1986, May-15, Volume: 35, Issue:10

    Topics: Animals; Brain Chemistry; Cells, Cultured; Endorphins; Ganglia, Spinal; Naloxone; Naltrexone; Neuroblastoma; Rats; Receptors, Opioid

1986
Multiple endogenous opiate and non-opiate analgesia systems: evidence of their existence and clinical implications.
    Annals of the New York Academy of Sciences, 1986, Volume: 467

    Topics: Acupuncture Therapy; Analgesia; Animals; Cholecystokinin; Conditioning, Classical; Desipramine; Dimethyl Sulfoxide; Drug Interactions; Electroshock; Endorphins; Enkephalin, Leucine; Mecamylamine; Morphine; N-Methylscopolamine; Naloxone; Naltrexone; Norepinephrine; Proglumide; Rats; Receptors, Cell Surface; Receptors, Cholecystokinin; Scopolamine; Scopolamine Derivatives; Serotonin; Spinal Cord

1986
Stressor controllability and stress-induced analgesia.
    Annals of the New York Academy of Sciences, 1986, Volume: 467

    Topics: Analgesia; Animals; Avoidance Learning; Electroshock; Injections, Spinal; Morphine; Naloxone; Naltrexone; Pain; Rats; Restraint, Physical; Sensory Thresholds; Stress, Physiological; Time Factors

1986
Endocrine and metabolic effects of opiate antagonists.
    The Journal of clinical psychiatry, 1984, Volume: 45, Issue:9 Pt 2

    Topics: Adrenocorticotropic Hormone; Animals; Body Weight; Eating; Endocrine Glands; Female; Follicle Stimulating Hormone; Hormones; Humans; Hydrocortisone; Luteinizing Hormone; Male; Mice; Naloxone; Naltrexone; Rats; Vasopressins

1984
[Narcotic withdrawal syndrome. Therapeutic methods].
    Revista clinica espanola, 1982, Oct-15, Volume: 167, Issue:1

    Topics: Acupuncture Therapy; Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Analgesia; Brain; Central Nervous System Agents; Clonidine; Endorphins; Humans; Methadone; Naloxone; Naltrexone; Narcotics; Receptors, Opioid; Substance Withdrawal Syndrome; Substance-Related Disorders

1982
Opiate receptor pharmacology: mixed agonist/antagonist narcotics.
    Contemporary anesthesia practice, 1983, Volume: 7

    Topics: Analgesics, Opioid; Buprenorphine; Butorphanol; Endorphins; Humans; Nalbuphine; Nalorphine; Naloxone; Naltrexone; Narcotic Antagonists; Pentazocine; Receptors, Opioid

1983
[Neuropeptide role in the etiology, pathogenesis and clinical aspects of mental diseases].
    Sovetskaia meditsina, 1984, Issue:6

    Topics: Animals; Anticonvulsants; Antipsychotic Agents; Depressive Disorder; Drug Therapy, Combination; Endorphins; Enkephalins; Humans; Mental Disorders; Naloxone; Naltrexone; Nerve Tissue Proteins; Pituitary Hormones; Psychotropic Drugs; Schizophrenia; Substance-Related Disorders; Vasopressins

1984
Autoanalgesia: opiate and non-opiate mechanisms.
    Neuroscience and biobehavioral reviews, 1980,Spring, Volume: 4, Issue:1

    Topics: Animals; Central Nervous System; Conditioning, Classical; Diazepam; Electroshock; Emotions; Endorphins; Fear; Hypophysectomy; Hypothalamus; Male; Mice; Naloxone; Naltrexone; Norepinephrine; Pain; Raphe Nuclei; Rats; Reaction Time; Receptors, Opioid; Serotonin; Spinal Cord

1980
The role of narcotic antagonists in the rehabilitation of opiate addicts: a review of naltrexone.
    The American journal of drug and alcohol abuse, 1980, Volume: 7, Issue:1

    Topics: Clinical Trials as Topic; Double-Blind Method; Endorphins; Humans; Methadone; Naloxone; Naltrexone; Opioid-Related Disorders; Receptors, Opioid

1980
The role of opioid peptides in memory and learning.
    Behavioural brain research, 1980, Volume: 1, Issue:6

    Topics: Amnesia; Animals; beta-Endorphin; Brain; Dopamine; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Humans; Learning; Memory; Naloxone; Naltrexone; Norepinephrine; Rats

1980
Current status of preclinical research on disposition, pharmacokinetics, and metabolism of naltrexone.
    NIDA research monograph, 1981, Volume: 28

    Topics: Animals; Biotransformation; Humans; Kinetics; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Tissue Distribution

1981
New and experimental therapeutic roles for naloxone and related opioid antagonists.
    Drugs, 1984, Volume: 27, Issue:1

    Topics: Alcohol Deterrents; Animals; Bipolar Disorder; Blood Pressure; Brain Ischemia; Clinical Trials as Topic; Humans; Lung Diseases, Obstructive; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Respiration; Schizophrenia; Shock; Spinal Injuries

1984
Minireview. Benzodiazepine-opiate antagonist interactions in relation to feeding and drinking behavior.
    Life sciences, 1983, Mar-07, Volume: 32, Issue:10

    Topics: Animals; Benzodiazepines; Corpus Striatum; Drinking Behavior; Enkephalins; Feeding Behavior; Food Deprivation; Humans; Hyperphagia; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Reward; Thirst

1983
The sequential use of clonidine and naltrexone in the treatment of opiate addicts.
    Advances in alcohol & substance abuse, 1984,Spring, Volume: 3, Issue:3

    Topics: Adult; Baclofen; Clonidine; Drug Therapy, Combination; Electric Stimulation Therapy; Endorphins; Ethanol; Female; Humans; Locus Coeruleus; Male; Methyldopa; Naloxone; Naltrexone; Opioid-Related Disorders; Substance Withdrawal Syndrome

1984
The physiology of opiate hedonic effects and the role of opioids in motivated behavior.
    Advances in alcohol & substance abuse, 1984,Spring, Volume: 3, Issue:3

    Topics: Animals; Conditioning, Operant; Electric Stimulation; Electroshock; Emotions; Endorphins; Feeding Behavior; Humans; Hypothalamus; Medial Forebrain Bundle; Morphine; Motivation; Naloxone; Naltrexone; Narcotics; Rats; Reward; Self Stimulation; Substance-Related Disorders

1984
A review of parenteral sustained-release naltrexone systems.
    NIDA research monograph, 1981, Volume: 28

    Topics: Biodegradation, Environmental; Chemistry, Pharmaceutical; Delayed-Action Preparations; Drug Compounding; Drug Implants; Drug Industry; Naloxone; Naltrexone

1981
Limitations on the antagonistic actions of opioid antagonists.
    Federation proceedings, 1982, Volume: 41, Issue:7

    Topics: Animals; Behavior, Animal; Columbidae; Conditioning, Operant; Cyclazocine; Macaca mulatta; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Saimiri

1982
Opiates and alcohol self-administration in animals.
    The Journal of clinical psychiatry, 1995, Volume: 56 Suppl 7

    Topics: Alcohol Drinking; Animals; Behavior, Animal; Ethanol; Humans; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Receptors, Opioid; Reinforcement, Psychology; Self Administration

1995
Opiate antagonists for the treatment of schizophrenia.
    Journal of clinical pharmacy and therapeutics, 1994, Volume: 19, Issue:5

    Topics: Hallucinations; Humans; Naloxone; Naltrexone; Schizophrenia

1994
Efficacy of psychotropic drugs for reducing self-injurious behavior in the developmental disabilities.
    Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists, 1993, Volume: 5, Issue:3

    Topics: Adrenergic beta-Antagonists; Anti-Anxiety Agents; Antidepressive Agents; Antipsychotic Agents; Female; Humans; Intellectual Disability; Lithium Carbonate; Male; Naloxone; Naltrexone; Receptors, Dopamine; Self-Injurious Behavior; Treatment Outcome

1993
Opiate detoxification protocols. A clinical manual.
    Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists, 1993, Volume: 5, Issue:1

    Topics: Administration, Cutaneous; Clinical Protocols; Clonidine; Codeine; Female; Humans; Male; Methadone; Naloxone; Naltrexone; Opioid-Related Disorders; Psychiatric Status Rating Scales; Receptors, Opioid; Substance Withdrawal Syndrome

1993
[Prevention of undesirable effects during the use of opiate antagonists].
    Klinische Anasthesiologie und Intensivtherapie, 1993, Volume: 42

    Topics: Humans; Naloxone; Naltrexone; Narcotic Antagonists

1993
Naltrexone: a case report of pruritus from an antipruritic.
    The Australasian journal of dermatology, 1997, Volume: 38, Issue:4

    Topics: Female; Humans; Injections, Subcutaneous; Middle Aged; Mycosis Fungoides; Naloxone; Naltrexone; Narcotic Antagonists; Pruritus; Skin Neoplasms

1997
Rapid and ultrarapid opioid detoxification techniques.
    JAMA, 1998, Jan-21, Volume: 279, Issue:3

    Topics: Clinical Trials as Topic; Humans; Naloxone; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Research Design; Substance Withdrawal Syndrome

1998
Nalmefene hydrochloride.
    Pediatric emergency care, 1999, Volume: 15, Issue:2

    Topics: Clinical Trials as Topic; Drug Overdose; Half-Life; Humans; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics

1999
Interactions between kappa opioid agonists and cocaine. Preclinical studies.
    Annals of the New York Academy of Sciences, 2000, Volume: 909

    Topics: Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Psychological; Discrimination Learning; Humans; Naloxone; Naltrexone; Receptors, Opioid, kappa; Self Administration

2000
Opioid antagonists in the treatment of opioid-induced constipation and pruritus.
    The Annals of pharmacotherapy, 2001, Volume: 35, Issue:1

    Topics: Clinical Trials as Topic; Constipation; Humans; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pruritus; Quaternary Ammonium Compounds

2001
Opioid antagonists for smoking cessation.
    The Cochrane database of systematic reviews, 2001, Issue:3

    Topics: Buprenorphine; Humans; Naloxone; Naltrexone; Narcotic Antagonists; Randomized Controlled Trials as Topic; Smoking; Smoking Cessation

2001
[Opioid detoxication under general anesthesia].
    Ugeskrift for laeger, 2002, Sep-02, Volume: 164, Issue:36

    Topics: Anesthesia, General; Evidence-Based Medicine; Humans; Inactivation, Metabolic; Infusions, Intravenous; Monitoring, Physiologic; Naloxone; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Randomized Controlled Trials as Topic

2002
[Cholestatic liver diseases].
    Therapeutische Umschau. Revue therapeutique, 2004, Volume: 61, Issue:8

    Topics: Anti-Bacterial Agents; Antibodies, Antineutrophil Cytoplasmic; Anticholesteremic Agents; Antipruritics; Autoimmune Diseases; Bile Ducts; Cholagogues and Choleretics; Cholangiography; Cholangitis; Cholangitis, Sclerosing; Cholestasis; Cholestyramine Resin; Clinical Enzyme Tests; Diagnosis, Differential; Hepatitis, Autoimmune; Humans; Immunosuppression Therapy; Inflammatory Bowel Diseases; Liver Cirrhosis; Liver Cirrhosis, Biliary; Liver Transplantation; Naloxone; Naltrexone; Narcotic Antagonists; Ondansetron; Plasmapheresis; Ursodeoxycholic Acid

2004
Basal opioid receptor activity, neutral antagonists, and therapeutic opportunities.
    Life sciences, 2005, Feb-11, Volume: 76, Issue:13

    Topics: Animals; Brain Chemistry; Calmodulin; Humans; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, mu; Signal Transduction

2005
Opioid antagonists with minimal sedation for opioid withdrawal.
    The Cochrane database of systematic reviews, 2006, Jan-25, Issue:1

    Topics: Adrenergic alpha-Agonists; Clinical Trials as Topic; Clonidine; Humans; Naloxone; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Randomized Controlled Trials as Topic

2006
Role of opioid antagonists in the treatment of women with glucoregulation abnormalities.
    Current pharmaceutical design, 2006, Volume: 12, Issue:8

    Topics: Clinical Trials as Topic; Endorphins; Female; Humans; Hyperinsulinism; Insulin Resistance; Menopause; Naloxone; Naltrexone; Narcotic Antagonists; Obesity; Polycystic Ovary Syndrome

2006
Antagonist treatment of opioid withdrawal translational low dose approach.
    Journal of addictive diseases, 2006, Volume: 25, Issue:2

    Topics: Animals; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Humans; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Substance Withdrawal Syndrome

2006
Opioid antagonists for smoking cessation.
    The Cochrane database of systematic reviews, 2006, Oct-18, Issue:4

    Topics: Buprenorphine; Humans; Naloxone; Naltrexone; Narcotic Antagonists; Randomized Controlled Trials as Topic; Smoking; Smoking Cessation

2006
Mu-opioid antagonists for opioid-induced bowel dysfunction.
    The Cochrane database of systematic reviews, 2008, Apr-16, Issue:2

    Topics: Constipation; Defecation; Gastrointestinal Agents; Humans; Intestinal Diseases; Nalbuphine; Naloxone; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Piperidines; Quaternary Ammonium Compounds; Receptors, Opioid, mu

2008
[News from the cochrane library: mu opioid antagonists for opioid-induced bowel dysfunction].
    Zeitschrift fur Gastroenterologie, 2008, Volume: 46, Issue:9

    Topics: Analgesics, Opioid; Clinical Trials as Topic; Constipation; Gastrointestinal Transit; Humans; Nalbuphine; Naloxone; Naltrexone; Narcotic Antagonists; Piperidines; Quaternary Ammonium Compounds; Receptors, Opioid, mu

2008
Opioid receptors in the gastrointestinal tract.
    Regulatory peptides, 2009, Jun-05, Volume: 155, Issue:1-3

    Topics: Animals; Constipation; Gastrointestinal Tract; Humans; Naloxone; Naltrexone; Narcotic Antagonists; Piperidines; Quaternary Ammonium Compounds; Receptors, Opioid

2009
Opioid antagonists with minimal sedation for opioid withdrawal.
    The Cochrane database of systematic reviews, 2009, Oct-07, Issue:4

    Topics: Adrenergic alpha-Agonists; Clinical Trials as Topic; Clonidine; Humans; Naloxone; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Randomized Controlled Trials as Topic; Substance Withdrawal Syndrome

2009
Opioid antagonists under heavy sedation or anaesthesia for opioid withdrawal.
    The Cochrane database of systematic reviews, 2010, Jan-20, Issue:1

    Topics: Anesthetics; Humans; Hypnotics and Sedatives; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Randomized Controlled Trials as Topic; Substance Withdrawal Syndrome

2010
The pharmacological treatment of opioid addiction--a clinical perspective.
    European journal of clinical pharmacology, 2010, Volume: 66, Issue:6

    Topics: Adrenergic Agonists; Analgesics, Opioid; Buprenorphine; Clonidine; Drug Therapy, Combination; Humans; Inactivation, Metabolic; Methadone; Naloxone; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Social Support; Substance Withdrawal Syndrome

2010
Antipruritic treatment with systemic μ-opioid receptor antagonists: a review.
    Journal of the American Academy of Dermatology, 2010, Volume: 63, Issue:4

    Topics: Administration, Oral; Antipruritics; Chronic Disease; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Male; Naloxone; Naltrexone; Pruritus; Randomized Controlled Trials as Topic; Receptors, Opioid, mu; Risk Assessment; Severity of Illness Index; Treatment Outcome

2010
The role of opioid receptor antagonists in the treatment of opioid-induced constipation: a review.
    Advances in therapy, 2010, Volume: 27, Issue:10

    Topics: Analgesics, Opioid; Clinical Trials as Topic; Constipation; Delayed-Action Preparations; Drug Combinations; Humans; Laxatives; Naloxone; Naltrexone; Narcotic Antagonists; Oxycodone; Quaternary Ammonium Compounds

2010
Use of pure opioid antagonists for management of opioid-induced pruritus.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2011, Aug-01, Volume: 68, Issue:15

    Topics: Adult; Analgesics, Opioid; Child; Humans; Infusions, Intravenous; Naloxone; Naltrexone; Narcotic Antagonists; Pruritus; Quality of Life; Quaternary Ammonium Compounds

2011
Opioid receptor heteromers in analgesia.
    Expert reviews in molecular medicine, 2012, Apr-10, Volume: 14

    Topics: Analgesia; Analgesics; Animals; Drug Antagonism; Drug Overdose; Humans; Morphine Dependence; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Protein Multimerization; Protein Structure, Quaternary; Receptors, Opioid, delta; Receptors, Opioid, mu; Signal Transduction; United States

2012
Opioid antagonists for pain.
    Expert opinion on investigational drugs, 2013, Volume: 22, Issue:4

    Topics: Animals; Humans; Naloxone; Naltrexone; Narcotic Antagonists; Pain

2013
Pharmacotherapies for treating opioid use disorder.
    CNS spectrums, 2013, Volume: 18, Issue:6

    Topics: Age Factors; Humans; Naloxone; Naltrexone; Narcotic Antagonists; Opiate Substitution Treatment; Opioid-Related Disorders; Prevalence; United States

2013
Opioid antagonists for smoking cessation.
    The Cochrane database of systematic reviews, 2013, Jun-06, Issue:6

    Topics: Buprenorphine; Humans; Naloxone; Naltrexone; Narcotic Antagonists; Randomized Controlled Trials as Topic; Smoking; Smoking Cessation; Tobacco Use Cessation Devices

2013
Efficacy of pharmacological therapies for the treatment of opioid-induced constipation: systematic review and meta-analysis.
    The American journal of gastroenterology, 2013, Volume: 108, Issue:10

    Topics: Alprostadil; Analgesics, Opioid; Benzofurans; Constipation; Female; Gastrointestinal Agents; Humans; Lubiprostone; Male; Naloxone; Naltrexone; Narcotic Antagonists; Peptides; Piperidines; Quaternary Ammonium Compounds; Receptors, Opioid, mu

2013
Overview and treatment of opioid-induced constipation.
    Postgraduate medicine, 2013, Volume: 125, Issue:4

    Topics: Analgesics, Opioid; Combined Modality Therapy; Constipation; Delayed-Action Preparations; Diet Therapy; Humans; Laxatives; Life Style; Naloxone; Naltrexone; Narcotic Antagonists; Piperidines; Quaternary Ammonium Compounds

2013
Opioid antagonists.
    Journal of pain and symptom management, 2014, Volume: 47, Issue:2

    Topics: Hospice Care; Humans; Internet; Naloxone; Naltrexone; Narcotic Antagonists; Palliative Care; Quaternary Ammonium Compounds

2014
Detoxification treatments for opiate dependent adolescents.
    The Cochrane database of systematic reviews, 2014, Apr-29, Issue:4

    Topics: Adolescent; Buprenorphine; Clonidine; Humans; Maintenance Chemotherapy; Naloxone; Naltrexone; Narcotic Antagonists; Opiate Substitution Treatment; Opioid-Related Disorders; Patient Dropouts; Randomized Controlled Trials as Topic

2014
Constipation: opioid antagonists in people prescribed opioids.
    BMJ clinical evidence, 2015, Sep-11, Volume: 2015

    Topics: Analgesics, Opioid; Constipation; Gastrointestinal Agents; Humans; Naloxone; Naltrexone; Narcotic Antagonists; Piperidines; Quaternary Ammonium Compounds; Treatment Outcome

2015
Opioid Use Disorders.
    Child and adolescent psychiatric clinics of North America, 2016, Volume: 25, Issue:3

    Topics: Adolescent; Analgesics, Opioid; Buprenorphine; Drug Overdose; Humans; Naloxone; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders

2016
Neuroscience in gambling policy and treatment: an interdisciplinary perspective.
    The lancet. Psychiatry, 2017, Volume: 4, Issue:6

    Topics: Administrative Personnel; Appetite Depressants; Decision Making; Diagnostic and Statistical Manual of Mental Disorders; Disruptive, Impulse Control, and Conduct Disorders; Gambling; Harm Reduction; Humans; Naloxone; Naltrexone; Narcotic Antagonists; Neurosciences; Public Health

2017
Opioid antagonists with minimal sedation for opioid withdrawal.
    The Cochrane database of systematic reviews, 2017, 05-29, Volume: 5

    Topics: Adrenergic alpha-Agonists; Clonidine; Humans; Naloxone; Naltrexone; Narcotic Antagonists; Non-Randomized Controlled Trials as Topic; Opioid-Related Disorders; Prospective Studies; Randomized Controlled Trials as Topic; Severity of Illness Index; Substance Withdrawal Syndrome

2017
Efficacy of pharmacological therapies for the treatment of opioid-induced constipation: systematic review and network meta-analysis.
    Gut, 2019, Volume: 68, Issue:3

    Topics: Analgesics, Opioid; Gastrointestinal Agents; Humans; Naloxone; Naltrexone; Narcotic Antagonists; Opioid-Induced Constipation; Randomized Controlled Trials as Topic

2019
Mu-opioid antagonists for opioid-induced bowel dysfunction in people with cancer and people receiving palliative care.
    The Cochrane database of systematic reviews, 2018, 06-05, Volume: 6

    Topics: Constipation; Defecation; Female; Gastrointestinal Agents; Humans; Intestinal Diseases; Male; Nalbuphine; Naloxone; Naltrexone; Narcotic Antagonists; Neoplasms; Opioid-Related Disorders; Oxycodone; Palliative Care; Piperidines; Quaternary Ammonium Compounds; Randomized Controlled Trials as Topic; Receptors, Opioid, mu

2018
Naloxone and Maintenance Naltrexone as Novel and Effective Therapies for Immunotherapy-Induced Pruritus: A Case Report and Brief Literature Review.
    Journal of oncology practice, 2019, Volume: 15, Issue:6

    Topics: Aged; Antibodies, Monoclonal, Humanized; Anus Neoplasms; Carcinoma, Squamous Cell; Female; Humans; Immunotherapy; Naloxone; Naltrexone; Narcotic Antagonists; Prognosis; Pruritus; Rectal Neoplasms

2019
    International journal of disaster risk reduction : IJDRR, 2020, Volume: 49

    Topics: Acyclic Monoterpenes; Adipose Tissue; Adolescent; Adult; Aged; Aged, 80 and over; Air Pollutants; Air Pollutants, Occupational; Amino Acid Transport Systems; Analgesics, Opioid; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Arthrobacter; Bacteria; Bacteriological Techniques; Benzaldehydes; Biodegradation, Environmental; Biofilms; Biological Transport; Biomarkers; Biomass; Bioreactors; Body Composition; Body Mass Index; Brassica; Brazil; Buprenorphine; Buprenorphine, Naloxone Drug Combination; Caco-2 Cells; Cadmium; Calcium; Calcium Carbonate; Calcium Channels; Catalysis; Cell Degranulation; Cell Line; Cell Membrane; Chitosan; Chromatography, High Pressure Liquid; Chromium; Cobalt; Cohort Studies; Colony Count, Microbial; Composting; Copper; COVID-19; Cross-Sectional Studies; Cytoplasm; Delayed-Action Preparations; Diabetes Mellitus, Type 2; Diarrhea; Diethylhexyl Phthalate; Dose-Response Relationship, Drug; Drug Implants; Drug Stability; Drug Synergism; Electroplating; Endometrial Neoplasms; Endometrium; Environmental Monitoring; Environmental Restoration and Remediation; Estradiol; Estrogens; Feces; Female; Food Microbiology; Food Preservation; Fruit and Vegetable Juices; Gasotransmitters; Gastrointestinal Diseases; Gastrointestinal Microbiome; Gene Expression Regulation, Developmental; Genetic Predisposition to Disease; Glutathione; Gold; Graphite; Growth Hormone; Harm Reduction; Hot Temperature; Humans; Hydrocortisone; Hydrogen; Hydrogen Peroxide; Hydrogen Sulfide; Hydrogen-Ion Concentration; Ileum; Imidazoles; Injections, Intraperitoneal; Insecticides; Insulin-Like Growth Factor Binding Protein 1; Insulin-Like Growth Factor Binding Protein 2; Insulin-Like Growth Factor Binding Protein 5; Insulin-Like Growth Factor I; Intestinal Absorption; Light; Lignin; Liver; Magnetics; Male; Manganese; Mast Cells; Melanoma; Membrane Potentials; Metals; Methadone; Microbial Viability; Microplastics; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Middle Aged; Mitochondrial Swelling; Molecular Dynamics Simulation; Monophenol Monooxygenase; Morocco; Naloxone; Naltrexone; Nanocomposites; Nanomedicine; Nanoparticles; Narcotic Antagonists; Neonicotinoids; Nitric Oxide; Nitro Compounds; Nitrogen; Nitrogen Compounds; Obesity; Obesity, Abdominal; Occupational Exposure; Ontario; Opiate Substitution Treatment; Opioid-Related Disorders; Oryza; Overweight; Oxidative Stress; Oxides; Oxygen; Perception; Photoelectron Spectroscopy; Plants; Plastics; Point Mutation; Polychlorinated Biphenyls; Polycyclic Aromatic Hydrocarbons; Potassium; Premenopause; Prodrugs; Prospective Studies; Protons; Pyrolysis; Qualitative Research; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Resins, Synthetic; Rhodamines; Risk Factors; ROC Curve; Salmo salar; SARS-CoV-2; Seawater; Severity of Illness Index; Sewage; Social Media; Soil; Soil Microbiology; Soil Pollutants; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman; Staining and Labeling; Stainless Steel; Steel; Stress, Physiological; Substance Abuse Treatment Centers; Symporters; T-Lymphocytes; Toluene; Triclosan; Ultraviolet Rays; Waist Circumference; Waste Disposal, Fluid; Wastewater; Water Purification; Welding; X-Ray Diffraction; Young Adult

2020
[Treatment of borderline personality disorder with opioid antagonists: buprenorphine, nalmefene, naloxone and naltrexone in the treatment of dissociative symptoms, self-mutilation and suicidal behavior].
    Vertex (Buenos Aires, Argentina), 2020, Volume: XXX, Issue:148

    Topics: Borderline Personality Disorder; Buprenorphine; Dissociative Disorders; Humans; Naloxone; Naltrexone; Narcotic Antagonists; Observational Studies as Topic; Self Mutilation; Suicidal Ideation

2020
Unconventional anxiety pharmacology in zebrafish: Drugs beyond traditional anxiogenic and anxiolytic spectra.
    Pharmacology, biochemistry, and behavior, 2021, Volume: 207

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Aspirin; Behavior, Animal; Disease Models, Animal; Humans; Lysergic Acid Diethylamide; Motor Activity; Naloxone; Naltrexone; Nicotine; Zebrafish

2021
Mu-opioid antagonists for opioid-induced bowel dysfunction in people with cancer and people receiving palliative care.
    The Cochrane database of systematic reviews, 2022, 09-15, Volume: 9

    Topics: Adult; Analgesics, Opioid; Child; Humans; Naloxone; Naltrexone; Narcotic Antagonists; Neoplasms; Opioid-Induced Constipation; Oxycodone; Palliative Care; Quaternary Ammonium Compounds; Substance Withdrawal Syndrome

2022
Ligand-Free Signaling of G-Protein-Coupled Receptors: Relevance to μ Opioid Receptors in Analgesia and Addiction.
    Molecules (Basel, Switzerland), 2022, Sep-08, Volume: 27, Issue:18

    Topics: Analgesia; Analgesics, Opioid; Humans; Ligands; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Pain; Receptors, Opioid, mu

2022
Treatment of dissociative symptoms with opioid antagonists: a systematic review.
    European journal of psychotraumatology, 2023, Volume: 14, Issue:2

    Topics: Dissociative Disorders; Humans; Naloxone; Naltrexone; Narcotic Antagonists

2023

Trials

65 trial(s) available for naltrexone and naloxone

ArticleYear
Effect of an opiate antagonist on movement disorders.
    Archives of neurology, 1978, Volume: 35, Issue:12

    Topics: Adult; Aged; Clinical Trials as Topic; Enkephalins; Humans; Huntington Disease; Middle Aged; Naloxone; Naltrexone; Parkinson Disease

1978
NIDA's naltrexone research program.
    NIDA research monograph, 1976, Issue:9

    Topics: Clinical Trials as Topic; Conditioning, Psychological; Cyclazocine; Drug Evaluation; Euphoria; Heroin; Heroin Dependence; Humans; Naloxone; Naltrexone; Narcotic Antagonists; Research; Research Support as Topic; United States; United States Substance Abuse and Mental Health Services Administration

1976
Effects of naltrexone on mood and neuroendocrine function in normal adult males.
    Psychoneuroendocrinology, 1978, Volume: 3, Issue:3-4

    Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Emotions; Humans; Libido; Luteinizing Hormone; Male; Naloxone; Naltrexone; Receptors, Opioid

1978
Clinical evaluation of naltrexone treatment of opiate-dependent individuals. Report of the National Research Council Committee on Clinical Evaluation of Narcotic Antagonists.
    Archives of general psychiatry, 1978, Volume: 35, Issue:3

    Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; Heroin; Heroin Dependence; Humans; Male; Methadone; Motivation; Naloxone; Naltrexone; Patient Compliance; Placebos; Research Design; Social Adjustment

1978
The double-blind crossover trial design: how good is it for psychoactive drugs?
    The American journal of drug and alcohol abuse, 1979, Volume: 6, Issue:2

    Topics: Adult; Cyclazocine; Double-Blind Method; Humans; Male; Naloxone; Naltrexone; Opioid-Related Disorders

1979
EEG and other effects of naltrexone and heroin in man.
    Pharmakopsychiatrie, Neuro-Psychopharmakologie, 1979, Volume: 12, Issue:1

    Topics: Auditory Threshold; Circadian Rhythm; Electroencephalography; Electrooculography; Heroin; Heroin Dependence; Humans; Male; Naloxone; Naltrexone; Time Factors

1979
Controlled clinical study of naltrexone side effects comparing first-day doses and maintenance regimens.
    The American journal of drug and alcohol abuse, 1978, Volume: 5, Issue:2

    Topics: Administration, Oral; Adolescent; Adult; Double-Blind Method; Drug Administration Schedule; Heroin Dependence; Humans; Male; Middle Aged; Naloxone; Naltrexone; Placebos; Self-Assessment

1978
Naltrexone: physiological and psychological effects of single doses.
    Clinical pharmacology and therapeutics, 1976, Volume: 19, Issue:6

    Topics: Blood Pressure; Body Temperature; Clinical Trials as Topic; Heart Rate; Humans; Male; Naloxone; Naltrexone; Placebos; Psychological Tests; Pupil; Respiration; Time Factors

1976
Experiences with Naltrexone in Buffalo.
    The American journal of drug and alcohol abuse, 1975, Volume: 2, Issue:3-4

    Topics: Administration, Oral; Clinical Trials as Topic; Consumer Behavior; Female; Heroin Dependence; Hospitalization; Humans; Male; Motivation; Naloxone; Naltrexone; New York; Outpatient Clinics, Hospital; Patient Dropouts

1975
Narcotic antagonists: naltrexone progress report: introduction.
    NIDA research monograph, 1976, Issue:9

    Topics: Clinical Trials as Topic; Drug Evaluation; Heroin Dependence; Humans; Male; Naloxone; Naltrexone; Research

1976
Clinical experience with naltrexone in a behavioral research study: an interim report.
    NIDA research monograph, 1976, Issue:9

    Topics: Adult; Behavior; Clinical Trials as Topic; Counseling; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Illicit Drugs; Male; Middle Aged; Motivation; Naloxone; Naltrexone; Outpatient Clinics, Hospital; Patient Compliance; Patient Dropouts; Substance-Related Disorders

1976
Comparison of two naltrexone treatment programs: naltrexone alone versus naltrexone plus behavior therapy.
    NIDA research monograph, 1976, Issue:9

    Topics: Adult; Behavior Therapy; Black or African American; Black People; Clinical Trials as Topic; Drug Administration Schedule; Drug Evaluation; Employment; Heroin Dependence; Humans; Male; Naloxone; Naltrexone; Narcotics; Patient Compliance; Spain; Students

1976
Interim report on clinic intake and safety data collected from 17 NIDA-funded naltrexone studies.
    NIDA research monograph, 1976, Issue:9

    Topics: Clinical Trials as Topic; Drug Administration Schedule; Humans; Naloxone; Naltrexone; Patient Dropouts; Statistics as Topic; Substance-Related Disorders

1976
Evolution of the National Academy of Sciences study of naltrexone.
    NIDA research monograph, 1976, Issue:9

    Topics: Academies and Institutes; Clinical Trials as Topic; Cyclazocine; Drug Evaluation; Heroin Dependence; Humans; Male; Naloxone; Naltrexone; Research Design; Research Support as Topic

1976
Varying clinical contexts for administering naltrexone.
    NIDA research monograph, 1976, Issue:9

    Topics: Adolescent; Adult; Clinical Trials as Topic; Drug Administration Schedule; Drug Evaluation; Humans; Male; Middle Aged; Naloxone; Naltrexone; Patient Compliance; Patient Dropouts; Research Design; Statistics as Topic; Substance-Related Disorders; Time Factors

1976
Patient response to naltrexone: issues of acceptance, treatment effects, and frequency of administration.
    NIDA research monograph, 1976, Issue:9

    Topics: Adult; Clinical Trials as Topic; Drug Evaluation; Heroin Dependence; Humans; Male; Naloxone; Naltrexone; Patient Acceptance of Health Care; Patient Dropouts; Substance-Related Disorders; Time Factors

1976
Naltrexone in methadone maintenance patients electing to become "drug free".
    NIDA research monograph, 1976, Issue:9

    Topics: Adult; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; Follow-Up Studies; Heroin Dependence; Humans; Male; Methadone; Naloxone; Naltrexone; Patient Dropouts; Research Design

1976
Comments and findings from a naltrexone double blind study.
    NIDA research monograph, 1976, Issue:9

    Topics: Clinical Trials as Topic; Humans; Methadone; Naloxone; Naltrexone; Research Design; Statistics as Topic; Substance-Related Disorders

1976
Factors influencing success in an antagonistic treatment program.
    NIDA research monograph, 1976, Issue:9

    Topics: Adult; Clinical Trials as Topic; Drug Evaluation; Heroin Dependence; Humans; Male; Naloxone; Naltrexone; Patient Compliance; Patient Dropouts; Research Design

1976
Clinical experiences with naltrexone in 370 detoxified addicts.
    NIDA research monograph, 1976, Issue:9

    Topics: Clinical Trials as Topic; Cyclazocine; Drug Administration Schedule; Humans; Methadone; Naloxone; Naltrexone; Patient Compliance; Physicians; Placebos; Research Personnel; Substance-Related Disorders

1976
Narcotic antagonist treatment of the criminal justice patient-institutional vs outpatient-including a 24 hour detox naltrexone induction regimen with oral medication.
    NIDA research monograph, 1976, Issue:9

    Topics: Adolescent; Adult; Clinical Trials as Topic; Counseling; Drug Administration Schedule; Drug Evaluation; Female; Halfway Houses; Humans; Male; Middle Aged; Naloxone; Naltrexone; Narcotic Antagonists; Outpatient Clinics, Hospital; Prisoners; Rehabilitation, Vocational; Research Design; Social Adjustment; Substance-Related Disorders

1976
Use of narcotic antagonists (naltrexone) in an addiction treatment program.
    NIDA research monograph, 1976, Issue:9

    Topics: Adolescent; Adult; Attitude; Clinical Trials as Topic; Drug Evaluation; Humans; Male; Middle Aged; Naloxone; Naltrexone; Patient Compliance; Personality Inventory; Self Medication; Substance-Related Disorders; Time Factors

1976
Naltrexone and cyclazocine. A controlled treatment study.
    Archives of general psychiatry, 1977, Volume: 34, Issue:10

    Topics: Administration, Oral; Adult; Cyclazocine; Double-Blind Method; Heroin Dependence; Humans; Male; Naloxone; Naltrexone; Placebos; Self-Assessment

1977
Phase II clinical trials of buprenorphine: detoxification and induction onto naltrexone.
    NIDA research monograph, 1992, Volume: 121

    Topics: Adult; Blood Pressure; Buprenorphine; Double-Blind Method; Female; Humans; Male; Methadone; Methoxyhydroxyphenylglycol; Naloxone; Naltrexone; Opioid-Related Disorders; Substance Withdrawal Syndrome

1992
Antiretroviral activity of naloxone and naltrexone.
    American journal of hospital pharmacy, 1991, Volume: 48, Issue:11

    Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; HIV-1; Humans; Killer Cells, Natural; Naloxone; Naltrexone

1991
Opioid antagonist challenges in buprenorphine maintained patients.
    Drug and alcohol dependence, 1990, Volume: 25, Issue:1

    Topics: Administration, Sublingual; Adult; Buprenorphine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Heroin Dependence; Humans; Infusions, Intravenous; Male; Methadone; Naloxone; Naltrexone; Substance Withdrawal Syndrome

1990
Beta-endorphin disregulation in autistic and self-injurious behavior: a neurodevelopmental hypothesis.
    Synapse (New York, N.Y.), 1988, Volume: 2, Issue:3

    Topics: Adult; Autistic Disorder; beta-Endorphin; Clinical Trials as Topic; Developmental Disabilities; Homeostasis; Humans; Male; Naloxone; Naltrexone

1988
Duration of antagonistic effects of nalmefene and naloxone in opiate-induced sedation for emergency department procedures.
    The American journal of emergency medicine, 1989, Volume: 7, Issue:2

    Topics: Adolescent; Adult; Aged; Attention; Consciousness; Double-Blind Method; Emergency Service, Hospital; Female; Humans; Male; Meperidine; Middle Aged; Multicenter Studies as Topic; Naloxone; Naltrexone; Random Allocation

1989
Effects of naloxone and naltrexone on self-injury: a double-blind, placebo-controlled analysis.
    American journal of mental retardation : AJMR, 1989, Volume: 93, Issue:6

    Topics: Autistic Disorder; Child; Clinical Trials as Topic; Conditioning, Operant; Double-Blind Method; Extinction, Psychological; Female; Half-Life; Humans; Naloxone; Naltrexone; Reinforcement Schedule; Self Mutilation

1989
Rapid detoxification from opioid dependence.
    The American journal of psychiatry, 1989, Volume: 146, Issue:10

    Topics: Buprenorphine; Clinical Trials as Topic; Double-Blind Method; Humans; Naloxone; Naltrexone; Opioid-Related Disorders; Placebos; Substance Withdrawal Syndrome

1989
Nontolerance to the opioid antagonism of naltrexone.
    Biological psychiatry, 1985, Volume: 20, Issue:1

    Topics: Adult; Arousal; Clinical Trials as Topic; Dose-Response Relationship, Drug; Double-Blind Method; Drug Tolerance; Euphoria; Female; Heart Rate; Heroin Dependence; Humans; Male; Middle Aged; Morphine; Naloxone; Naltrexone; Receptors, Opioid

1985
Naltrexone-induced dysphoria in former opioid addicts.
    The American journal of psychiatry, 1985, Volume: 142, Issue:9

    Topics: Adult; Affective Symptoms; Ejaculation; Emotions; Humans; Libido; Male; Motor Activity; Naloxone; Naltrexone; Opioid-Related Disorders; Receptors, Opioid

1985
Antagonism of morphine-induced respiratory depression with nalmefene.
    British journal of anaesthesia, 1988, Volume: 61, Issue:3

    Topics: Adult; Carbon Dioxide; Depression, Chemical; Humans; Male; Middle Aged; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Partial Pressure; Respiration; Time Factors

1988
Reduction of hyperinsulinemia and insulin resistance by opiate receptor blockade in the polycystic ovary syndrome with acanthosis nigricans.
    The Journal of clinical endocrinology and metabolism, 1987, Volume: 64, Issue:2

    Topics: Acanthosis Nigricans; Adolescent; Adult; Blood Glucose; Female; Humans; Insulin; Insulin Resistance; Naloxone; Naltrexone; Narcotic Antagonists; Polycystic Ovary Syndrome

1987
Naltrexone and human eating behavior: a dose-ranging inpatient trial in moderately obese men.
    Brain research bulletin, 1985, Volume: 14, Issue:6

    Topics: Adult; Basal Metabolism; Body Weight; Clinical Trials as Topic; Drug Administration Schedule; Energy Intake; Feeding Behavior; Humans; Male; Naloxone; Naltrexone; Obesity

1985
The role of the National Institute on Drug Abuse in the development of naltrexone.
    The Journal of clinical psychiatry, 1984, Volume: 45, Issue:9 Pt 2

    Topics: Aftercare; Animals; Carcinogens; Clinical Trials as Topic; Clonidine; Drug Administration Schedule; Drug and Narcotic Control; Drug Evaluation; Drug Evaluation, Preclinical; Female; Humans; Male; Mice; Motivation; Naloxone; Naltrexone; Opioid-Related Disorders; Patient Compliance; Rats; United States; United States Substance Abuse and Mental Health Services Administration

1984
The role of narcotic antagonists in the rehabilitation of opiate addicts: a review of naltrexone.
    The American journal of drug and alcohol abuse, 1980, Volume: 7, Issue:1

    Topics: Clinical Trials as Topic; Double-Blind Method; Endorphins; Humans; Methadone; Naloxone; Naltrexone; Opioid-Related Disorders; Receptors, Opioid

1980
Action of naloxone and naltrexone in different types of psychoses.
    Modern problems of pharmacopsychiatry, 1981, Volume: 17

    Topics: Bipolar Disorder; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Endorphins; Humans; Naloxone; Naltrexone; Psychotic Disorders; Receptors, Opioid; Schizophrenia

1981
New and experimental therapeutic roles for naloxone and related opioid antagonists.
    Drugs, 1984, Volume: 27, Issue:1

    Topics: Alcohol Deterrents; Animals; Bipolar Disorder; Blood Pressure; Brain Ischemia; Clinical Trials as Topic; Humans; Lung Diseases, Obstructive; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Respiration; Schizophrenia; Shock; Spinal Injuries

1984
Naltrexone precipitated opiate withdrawal in methadone addicted human subjects: evidence for noradrenergic hyperactivity.
    Life sciences, 1984, Sep-17, Volume: 35, Issue:12

    Topics: Adult; Blood Pressure; Brain; Female; Humans; Kinetics; Male; Methadone; Methoxyhydroxyphenylglycol; Naloxone; Naltrexone; Narcotics; Norepinephrine; Substance Withdrawal Syndrome; Substance-Related Disorders

1984
Naloxone and naltrexone in mental illness and tardive dyskinesia.
    Annals of the New York Academy of Sciences, 1982, Volume: 398

    Topics: Animals; Clinical Trials as Topic; Dyskinesia, Drug-Induced; Endorphins; Humans; Mood Disorders; Naloxone; Naltrexone; Rats; Schizophrenia

1982
Assessment of naltrexone in the treatment of schizophrenia.
    Psychopharmacology, 1981, Volume: 74, Issue:1

    Topics: Adult; Clinical Trials as Topic; Drug Administration Schedule; Female; Humans; Male; Naloxone; Naltrexone; Schizophrenia

1981
Naltrexone in chronic schizophrenia. Results of a clinical trial.
    International pharmacopsychiatry, 1980, Volume: 15, Issue:1

    Topics: Adult; Chronic Disease; Clinical Trials as Topic; Female; Humans; Male; Middle Aged; Naloxone; Naltrexone; Psychiatric Status Rating Scales; Schizophrenia

1980
Naltrexone treatment of heroin addiction: efficacy and safety in a double-blind dosage comparison.
    Drug and alcohol dependence, 1981, Volume: 7, Issue:4

    Topics: Adolescent; Adult; Clinical Trials as Topic; Dose-Response Relationship, Drug; Double-Blind Method; Female; Heroin Dependence; Humans; Male; Middle Aged; Naloxone; Naltrexone

1981
Clonidine and naltrexone. A safe, effective, and rapid treatment of abrupt withdrawal from methadone therapy.
    Archives of general psychiatry, 1982, Volume: 39, Issue:11

    Topics: Adult; Blood Pressure; Clonidine; Double-Blind Method; Drug Administration Schedule; Female; Heart Rate; Humans; Male; Methadone; Naloxone; Naltrexone; Opioid-Related Disorders; Substance Withdrawal Syndrome

1982
Aversive effects of naltrexone in subjects not dependent on opiates.
    Drug and alcohol dependence, 1981, Volume: 8, Issue:1

    Topics: Adult; Affect; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Male; Motivation; Naloxone; Naltrexone

1981
Operant analysis of human heroin self-administration and the effects of naltrexone.
    The Journal of pharmacology and experimental therapeutics, 1981, Volume: 216, Issue:1

    Topics: Adult; Conditioning, Operant; Heroin Dependence; Humans; Male; Methadone; Naloxone; Naltrexone; Placebos; Self Administration

1981
Naltrexone treatment restores menstrual cycles in patients with weight loss-related amenorrhea.
    Fertility and sterility, 1995, Volume: 64, Issue:5

    Topics: Administration, Oral; Amenorrhea; Body Mass Index; Dose-Response Relationship, Drug; Estrogen Replacement Therapy; Estrogens; Female; Follicle Stimulating Hormone; Humans; Luteinizing Hormone; Menstrual Cycle; Naloxone; Naltrexone; Narcotic Antagonists; Progestins; Weight Loss

1995
Comparison of potency and duration of action of nalmefene and naloxone.
    Anesthesia and analgesia, 1994, Volume: 78, Issue:3

    Topics: Adult; Double-Blind Method; Humans; Male; Naloxone; Naltrexone; Narcotic Antagonists; Reference Values; Time Factors

1994
Efficacy of methylnaltrexone versus naloxone for reversal of morphine-induced depression of hypoxic ventilatory response.
    Anesthesia and analgesia, 1994, Volume: 78, Issue:4

    Topics: Adult; Double-Blind Method; Humans; Hypoxia; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Respiration

1994
Efficacy and safety of two new methods of rapid intravenous detoxification in heroin addicts previously treated without success.
    The British journal of psychiatry : the journal of mental science, 1997, Volume: 171

    Topics: Adult; Conscious Sedation; Critical Care; Heroin Dependence; Humans; Inactivation, Metabolic; Infusions, Intravenous; Length of Stay; Middle Aged; Naloxone; Naltrexone; Narcotic Antagonists; Recurrence; Substance Withdrawal Syndrome; Treatment Failure

1997
Longer occupancy of opioid receptors by nalmefene compared to naloxone as measured in vivo by a dual-detector system.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1997, Volume: 38, Issue:11

    Topics: Adult; Analgesics, Opioid; Brain; Carbon Radioisotopes; Cross-Over Studies; Female; Fentanyl; Humans; Male; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Time Factors; Tomography, Emission-Computed

1997
Dynorphin A1-13 causes elevation of serum levels of prolactin through an opioid receptor mechanism in humans: gender differences and implications for modulation of dopaminergic tone in the treatment of addictions.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 288, Issue:1

    Topics: Adult; Analgesics, Opioid; Analysis of Variance; Cocaine-Related Disorders; Dose-Response Relationship, Drug; Dynorphins; Female; Humans; Male; Middle Aged; Naloxone; Naltrexone; Narcotic Antagonists; Peptide Fragments; Prolactin; Receptors, Dopamine; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sex Characteristics; Time Factors

1999
Opiate detoxification under anesthesia: no apparent benefit but suppression of thyroid hormones and risk of pulmonary and renal failure.
    Journal of toxicology. Clinical toxicology, 1999, Volume: 37, Issue:1

    Topics: Acute Kidney Injury; Adult; Anesthesia; Codeine; Female; Heroin Dependence; Humans; Male; Methadone; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Respiratory Insufficiency; Substance Withdrawal Syndrome; Thyroid Hormones

1999
Double-blind, randomized study of nalmefene and naloxone in emergency department patients with suspected narcotic overdose.
    Annals of emergency medicine, 1999, Volume: 34, Issue:1

    Topics: Adult; Double-Blind Method; Drug Overdose; Emergency Treatment; Humans; Injections, Intravenous; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Neurologic Examination; Respiration; Time Factors; Treatment Outcome

1999
Rapid opioid detoxification during general anesthesia: a review of 20 patients.
    Anesthesiology, 1999, Volume: 91, Issue:6

    Topics: Adult; Anesthesia, General; Combined Modality Therapy; Female; Humans; Male; Middle Aged; Monitoring, Physiologic; Naloxone; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Substance Withdrawal Syndrome

1999
Rapid opiate detoxication in outpatient treatment: relationship with naltrexone compliance.
    Journal of substance abuse treatment, 2000, Volume: 18, Issue:2

    Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Anti-Inflammatory Agents, Non-Steroidal; Baclofen; Clonidine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; GABA Agents; Heroin Dependence; Humans; Inactivation, Metabolic; Ketoprofen; Male; Methadone; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Oxazepam; Patient Compliance; Substance Withdrawal Syndrome; Treatment Outcome

2000
Plasma catecholamines during an ultrarapid heroin detoxification.
    Annals of the New York Academy of Sciences, 2000, Volume: 914

    Topics: Adult; Analysis of Variance; Catecholamines; Drug Administration Routes; Drug Therapy, Combination; Female; Heroin; Heroin Dependence; Humans; Inactivation, Metabolic; Male; Naloxone; Naltrexone; Narcotic Antagonists; Substance Withdrawal Syndrome; Systole; Treatment Outcome

2000
Influence of opioids in hypothalamic nuclei on cold thermogenesis of lean and obese LA/N-cp rats.
    Obesity research, 1994, Volume: 2, Issue:3

    Topics: Animals; Cold Temperature; Enkephalin, Leucine; Male; Naloxone; Naltrexone; Narcotic Antagonists; Obesity; Opioid Peptides; Oxygen Consumption; Paraventricular Hypothalamic Nucleus; Rats; Rats, Sprague-Dawley; Stress, Physiological; Thermogenesis

1994
Treatment of pruritus with topically applied opiate receptor antagonist.
    Journal of the American Academy of Dermatology, 2007, Volume: 56, Issue:6

    Topics: Administration, Topical; Adult; Aged; Cross-Over Studies; Dermatitis, Atopic; Double-Blind Method; Female; Humans; Male; Middle Aged; Naloxone; Naltrexone; Narcotic Antagonists; Pilot Projects; Prospective Payment System; Pruritus

2007
Reversal of opioid-induced bladder dysfunction by intravenous naloxone and methylnaltrexone.
    Clinical pharmacology and therapeutics, 2007, Volume: 82, Issue:1

    Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Double-Blind Method; Humans; Infusions, Intravenous; Male; Middle Aged; Miosis; Muscle Contraction; Naloxone; Naltrexone; Narcotic Antagonists; Piperidines; Quaternary Ammonium Compounds; Remifentanil; Treatment Outcome; Urinary Bladder; Urinary Retention; Urination

2007
Cocaine use reduction with buprenorphine (CURB): rationale, design, and methodology.
    Contemporary clinical trials, 2013, Volume: 34, Issue:2

    Topics: Administration, Sublingual; Adolescent; Adult; Aged; Buprenorphine; Buprenorphine, Naloxone Drug Combination; Cocaine-Related Disorders; Cognitive Behavioral Therapy; Combined Modality Therapy; Double-Blind Method; Drug Combinations; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Naloxone; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Treatment Outcome; Young Adult

2013
A randomized, double-blind evaluation of buprenorphine taper duration in primary prescription opioid abusers.
    JAMA psychiatry, 2013, Volume: 70, Issue:12

    Topics: Adult; Buprenorphine; Cognitive Behavioral Therapy; Combined Modality Therapy; Double-Blind Method; Drug Administration Schedule; Female; Humans; Male; Naloxone; Naltrexone; Narcotic Antagonists; Opiate Substitution Treatment; Opioid-Related Disorders; Psychiatric Status Rating Scales; Severity of Illness Index; Time Factors; Treatment Outcome; Young Adult

2013
Effect of methylnaltrexone and naloxone on esophageal motor function in man.
    Neurogastroenterology and motility, 2017, Volume: 29, Issue:3

    Topics: Adolescent; Adult; Cross-Over Studies; Esophageal pH Monitoring; Esophageal Sphincter, Lower; Female; Humans; Male; Naloxone; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Receptors, Opioid, mu; Single-Blind Method; Young Adult

2017
Naloxone and nalmefene absorption delivered by hollow microneedles compared to intramuscular injection.
    Drug delivery and translational research, 2022, Volume: 12, Issue:2

    Topics: Analgesics, Opioid; Animals; Cross-Over Studies; Dogs; Humans; Injections, Intramuscular; Naloxone; Naltrexone; Narcotic Antagonists

2022

Other Studies

1292 other study(ies) available for naltrexone and naloxone

ArticleYear
Quantum chemical studies of N-substituent variation in the oxymorphone series of opiate narcotics.
    Journal of medicinal chemistry, 1978, Volume: 21, Issue:1

    Topics: Analgesics, Opioid; Animals; Hydromorphone; In Vitro Techniques; Mice; Molecular Conformation; Oxymorphone; Quantum Theory; Rats; Structure-Activity Relationship; Swine; Thermodynamics

1978
Electrophilic opioid ligands. Oxygen tethered alpha-methylene-gamma-lactone, acrylate, isothiocyanate, and epoxide derivatives of 6 beta-naltrexol.
    Journal of medicinal chemistry, 1992, Jun-26, Volume: 35, Issue:13

    Topics: Acrylates; Animals; Binding Sites; Brain; Endorphins; Epoxy Compounds; Guinea Pigs; Lactones; Ligands; Naltrexone; Radioligand Assay; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stereoisomerism; Thiocyanates

1992
O3-(2-carbomethoxyallyl) ethers of opioid ligands derived from oxymorphone, naltrexone, etorphine, diprenorphine, norbinaltorphimine, and naltrindole. Unexpected O3-dealkylation in the opioid radioligand displacement assay.
    Journal of medicinal chemistry, 1992, Nov-27, Volume: 35, Issue:24

    Topics: Alkylation; Animals; Brain; Diprenorphine; Drug Stability; Ethers; Etorphine; Guinea Pigs; Indoles; Methacrylates; Molecular Structure; Morphinans; Naltrexone; Narcotic Antagonists; Narcotics; Oxymorphone; Phenols; Radioligand Assay; Receptors, Opioid; Tritium

1992
Electrophilic gamma-lactone kappa-opioid receptor probes. Analogues of 2'-hydroxy-2-tetrahydrofurfuryl-5,9-dimethyl-6,7-benzomorphan diastereomers.
    Journal of medicinal chemistry, 1991, Volume: 34, Issue:8

    Topics: Animals; Benzomorphans; Brain; Cell Membrane; Chemical Phenomena; Chemistry; Guinea Pigs; Molecular Conformation; Molecular Structure; Receptors, Opioid; Receptors, Opioid, kappa; Stereoisomerism; Structure-Activity Relationship

1991
Conjugate addition ligands of opioid antagonists. Methacrylate esters and ethers of 6 alpha- and 6 beta-naltrexol.
    Journal of medicinal chemistry, 1990, Volume: 33, Issue:2

    Topics: Animals; Benzomorphans; Binding, Competitive; Cattle; Caudate Nucleus; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Esters; Ethers; In Vitro Techniques; Ligands; Methacrylates; Naltrexone; Receptors, Opioid; Structure-Activity Relationship

1990
Photoactivatable opiate derivatives as irreversible probes of the mu-opioid receptor.
    Journal of medicinal chemistry, 1990, Volume: 33, Issue:9

    Topics: Affinity Labels; Animals; Azides; Azo Compounds; Binding Sites; Brain; Chemical Phenomena; Chemistry; Guinea Pigs; Narcotics; Rats; Receptors, Opioid; Receptors, Opioid, mu; Structure-Activity Relationship

1990
Synthesis and biological evaluation of 14-alkoxymorphinans. 2. (-)-N-(cyclopropylmethyl)-4,14-dimethoxymorphinan-6-one, a selective mu opioid receptor antagonist.
    Journal of medicinal chemistry, 1989, Volume: 32, Issue:2

    Topics: Animals; Guinea Pigs; In Vitro Techniques; Male; Mice; Morphinans; Narcotic Antagonists; Rats; Receptors, Opioid; Receptors, Opioid, mu

1989
Structure-activity relationships for drugs binding to the agonist and antagonist states of the primary morphine receptor.
    Journal of medicinal chemistry, 1988, Volume: 31, Issue:3

    Topics: Algorithms; Animals; Kinetics; Models, Molecular; Narcotic Antagonists; Narcotics; Protein Conformation; Rats; Receptors, Opioid; Structure-Activity Relationship

1988
Long-acting opiate agonists and antagonists: 14-hydroxydihydromorphinone hydrazones.
    Journal of medicinal chemistry, 1980, Volume: 23, Issue:6

    Topics: Analgesics, Opioid; Animals; Brain; Delayed-Action Preparations; Hydrazones; Hydromorphone; In Vitro Techniques; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Oxymorphone; Rats; Receptors, Opioid

1980
Allylprodine analogues as receptor probes. Evidence that phenolic and nonphenolic ligands interact with different subsites on identical opioid receptors.
    Journal of medicinal chemistry, 1981, Volume: 24, Issue:7

    Topics: Animals; Chemical Phenomena; Chemistry, Physical; Guinea Pigs; Ileum; In Vitro Techniques; Ligands; Mice; Morphine; Muscle Contraction; Muscle, Smooth; Narcotic Antagonists; Phenols; Piperidines; Reaction Time; Receptors, Opioid; Structure-Activity Relationship

1981
Common anionic receptor site hypothesis: its relevance to the antagonist action of naloxone.
    Journal of medicinal chemistry, 1982, Volume: 25, Issue:2

    Topics: Animals; Anions; Chemical Phenomena; Chemistry; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Narcotics; Rats; Receptors, Opioid

1982
Different receptor sites mediate opioid agonism and antagonism.
    Journal of medicinal chemistry, 1983, Volume: 26, Issue:10

    Topics: Animals; Binding Sites; Kinetics; Naltrexone; Narcotic Antagonists; Narcotics; Receptors, Opioid; Structure-Activity Relationship

1983
Analgesic narcotic antagonists. 9. 6-Methylene-8 beta-alkyl-N-(cycloalkylmethyl)-3-hydroxy- or -methoxymorphinans.
    Journal of medicinal chemistry, 1981, Volume: 24, Issue:12

    Topics: Analgesics; Animals; Chemical Phenomena; Chemistry; Haplorhini; Humans; Mice; Morphinans; Morphine Dependence; Narcotic Antagonists; Rats; Reaction Time; Substance Withdrawal Syndrome

1981
Some 14 beta-substituted analogues of N-(cyclopropylmethyl)normorphine.
    Journal of medicinal chemistry, 1981, Volume: 24, Issue:2

    Topics: Animals; Chemical Phenomena; Chemistry; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Morphine; Morphine Derivatives; Muscle, Smooth; Vas Deferens

1981
kappa-Opioid receptor in humans: cDNA and genomic cloning, chromosomal assignment, functional expression, pharmacology, and expression pattern in the central nervous system.
    Proceedings of the National Academy of Sciences of the United States of America, 1995, Jul-18, Volume: 92, Issue:15

    Topics: Adenylyl Cyclases; Aged; Amino Acid Sequence; Base Sequence; Central Nervous System; Chromosome Mapping; Chromosomes, Human, Pair 8; Cloning, Molecular; DNA, Complementary; Exons; Genomic Library; Humans; In Situ Hybridization; Ligands; Middle Aged; Molecular Sequence Data; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Proteins; RNA, Messenger; Sequence Homology, Amino Acid; Signal Transduction; Tissue Distribution

1995
Discovery of a potent, peripherally selective trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine opioid antagonist for the treatment of gastrointestinal motility disorders.
    Journal of medicinal chemistry, 1994, Jul-22, Volume: 37, Issue:15

    Topics: Animals; Diarrhea; Gastrointestinal Motility; Guinea Pigs; In Vitro Techniques; Intestinal Diseases; Male; Mice; Piperidines; Radioligand Assay; Receptors, Opioid, mu; Structure-Activity Relationship

1994
Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors.
    Molecular pharmacology, 1994, Volume: 45, Issue:2

    Topics: Analgesics; Animals; Binding Sites; Cell Line; CHO Cells; Cloning, Molecular; Cricetinae; Ligands; PC12 Cells; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Software

1994
Cloning and functional comparison of kappa and delta opioid receptors from mouse brain.
    Proceedings of the National Academy of Sciences of the United States of America, 1993, Jul-15, Volume: 90, Issue:14

    Topics: Amino Acid Sequence; Animals; Base Sequence; Brain Chemistry; Cloning, Molecular; In Situ Hybridization; Mice; Molecular Sequence Data; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Somatostatin; RNA, Messenger; Sequence Homology, Amino Acid; Substrate Specificity; Tissue Distribution

1993
Structure-activity relationships of trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine antagonists for mu- and kappa-opioid receptors.
    Journal of medicinal chemistry, 1993, Oct-01, Volume: 36, Issue:20

    Topics: Analgesia; Animals; Diuresis; Furans; Male; Mice; Molecular Structure; Morphine; Piperidines; Rats; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stereoisomerism; Structure-Activity Relationship

1993
3,4-Dimethyl-4-(3-hydroxyphenyl)piperidines: opioid antagonists with potent anorectant activity.
    Journal of medicinal chemistry, 1993, Oct-01, Volume: 36, Issue:20

    Topics: Analgesia; Animals; Appetite Depressants; Cyclohexanes; Diuresis; Eating; Endorphins; Guinea Pigs; Male; Mice; Molecular Structure; Piperidines; Rats; Rats, Sprague-Dawley; Rats, Zucker; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship

1993
Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications.
    NIDA research monograph, 1998, Volume: 178

    Topics: Animals; Aorta, Thoracic; Cocaine; Cyclic AMP; Electric Stimulation; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Mice; Muscle, Smooth; Opioid-Related Disorders; Rats; Receptors, Dopamine; Receptors, Opioid; Receptors, Serotonin; Substance-Related Disorders

1998
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs.
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 303, Issue:3

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Cell Line; Cell Membrane Permeability; Central Nervous System Agents; Dogs; Drug Delivery Systems; Permeability; Pharmaceutical Preparations

2002
Elucidation of the bioactive conformation of the N-substituted trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine class of mu-opioid receptor antagonists.
    Journal of medicinal chemistry, 2006, Dec-14, Volume: 49, Issue:25

    Topics: Animals; CHO Cells; Cricetinae; Cricetulus; Crystallography, X-Ray; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Ligands; Models, Molecular; Molecular Conformation; Piperidines; Radioligand Assay; Receptors, Opioid, mu; Stereoisomerism; Structure-Activity Relationship

2006
Synthesis and pharmacological evaluation of novel octahydro-1H-pyrido[1,2-a]pyrazine as mu-opioid receptor antagonists.
    Journal of medicinal chemistry, 2006, Dec-14, Volume: 49, Issue:25

    Topics: Animals; CHO Cells; Cricetinae; Cricetulus; Crystallography, X-Ray; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Ligands; Molecular Structure; Pyrazines; Pyridines; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship

2006
Naloxone acts as a potent analgesic in transgenic mouse models of sickle cell anemia.
    Proceedings of the National Academy of Sciences of the United States of America, 2007, Apr-03, Volume: 104, Issue:14

    Topics: Analgesics; Analgesics, Opioid; Anemia, Sickle Cell; Animals; Chemokine CCL5; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Drug Synergism; Injections, Intraventricular; Injections, Spinal; Injections, Subcutaneous; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Knockout; Mice, Transgenic; Morphine; Naloxone; Pain; Pain Measurement; Receptors, CCR5

2007
Pharmacological properties of bivalent ligands containing butorphan linked to nalbuphine, naltrexone, and naloxone at mu, delta, and kappa opioid receptors.
    Journal of medicinal chemistry, 2007, May-03, Volume: 50, Issue:9

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; CHO Cells; Cricetinae; Cricetulus; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Ligands; Morphinans; Nalbuphine; Naloxone; Naltrexone; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship

2007
Hologram QSAR model for the prediction of human oral bioavailability.
    Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24

    Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2007
The influence of esters and carboxylic acids as the N-substituent of opioids. Part 1: Benzomorphans.
    Bioorganic & medicinal chemistry, 2008, Jan-15, Volume: 16, Issue:2

    Topics: Analgesics, Opioid; Benzomorphans; Carboxylic Acids; Esters; Molecular Structure; Stereoisomerism; Structure-Activity Relationship

2008
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Syntheses and opioid receptor binding properties of carboxamido-substituted opioids.
    Bioorganic & medicinal chemistry letters, 2009, Jan-01, Volume: 19, Issue:1

    Topics: Amides; Analgesics, Opioid; Humans; Protein Binding; Receptors, Opioid; Structure-Activity Relationship; Tramadol

2009
Design, synthesis, and biological evaluation of 6alpha- and 6beta-N-heterocyclic substituted naltrexamine derivatives as mu opioid receptor selective antagonists.
    Journal of medicinal chemistry, 2009, Mar-12, Volume: 52, Issue:5

    Topics: Amino Acid Sequence; Analgesics; Analgesics, Opioid; Animals; Binding Sites; Binding, Competitive; CHO Cells; Cricetinae; Cricetulus; Drug Design; Ligands; Models, Molecular; Molecular Sequence Data; Morphinans; Morphine; Naltrexone; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sequence Alignment; Structure-Activity Relationship

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Probes for narcotic receptor mediated phenomena. 41. Unusual inverse μ-agonists and potent μ-opioid antagonists by modification of the N-substituent in enantiomeric 5-(3-hydroxyphenyl)morphans.
    Journal of medicinal chemistry, 2011, Feb-24, Volume: 54, Issue:4

    Topics: Animals; Binding, Competitive; CHO Cells; Cricetinae; Cricetulus; Cyclopropanes; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Magnetic Resonance Spectroscopy; Morphinans; Receptors, Opioid, mu; Spectrometry, Mass, Electrospray Ionization; Stereoisomerism; Structure-Activity Relationship

2011
Generation of novel radiolabeled opiates through site-selective iodination.
    Bioorganic & medicinal chemistry letters, 2011, Jul-01, Volume: 21, Issue:13

    Topics: Animals; Binding Sites; Binding, Competitive; CHO Cells; Cricetinae; Cricetulus; Humans; Iodine Radioisotopes; Molecular Structure; Neurotransmitter Agents; Oxymorphone; Radioligand Assay; Receptors, Opioid

2011
Synthesis of novel triplet drugs with 1,3,5-trioxazatriquinane skeletons and their pharmacologies. Part 2: Synthesis of novel triplet drugs with the epoxymethano structure (capped homotriplet).
    Bioorganic & medicinal chemistry letters, 2011, Oct-15, Volume: 21, Issue:20

    Topics: Analgesics, Opioid; Animals; Bridged-Ring Compounds; Mice; Models, Molecular; Nitriles; Nociception; Nociceptive Pain; Pain Measurement; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sesquiterpenes; Tosyl Compounds

2011
Synthesis and evaluation of aryl-naloxamide opiate analgesics targeting truncated exon 11-associated μ opioid receptor (MOR-1) splice variants.
    Journal of medicinal chemistry, 2012, Jul-26, Volume: 55, Issue:14

    Topics: Amides; Analgesics; Animals; Behavior, Animal; Brain; Cell Line; Chemistry Techniques, Synthetic; Exons; Male; Mice; Opiate Alkaloids; Protein Isoforms; Protein Structure, Tertiary; Receptors, Opioid, mu; Structure-Activity Relationship

2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
Design, synthesis, and biological evaluation of 14-heteroaromatic-substituted naltrexone derivatives: pharmacological profile switch from mu opioid receptor selectivity to mu/kappa opioid receptor dual selectivity.
    Journal of medicinal chemistry, 2013, Nov-27, Volume: 56, Issue:22

    Topics: Animals; Behavior, Animal; Chemistry Techniques, Synthetic; CHO Cells; Cricetinae; Cricetulus; Drug Design; Male; Mice; Models, Molecular; Naltrexone; Protein Conformation; Receptors, Opioid, kappa; Receptors, Opioid, mu; Substrate Specificity

2013
Opioids and efflux transporters. Part 4: influence of N-substitution on P-glycoprotein substrate activity of noroxymorphone analogues.
    Bioorganic & medicinal chemistry letters, 2014, Aug-01, Volume: 24, Issue:15

    Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Dose-Response Relationship, Drug; Humans; Models, Molecular; Molecular Conformation; Morphinans; Structure-Activity Relationship

2014
Synthesis, Biological Evaluation, and Utility of Fluorescent Ligands Targeting the μ-Opioid Receptor.
    Journal of medicinal chemistry, 2015, Dec-24, Volume: 58, Issue:24

    Topics: Animals; Binding, Competitive; Buprenorphine; CHO Cells; Cricetulus; Fluorescent Dyes; HEK293 Cells; Humans; Ligands; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Radioligand Assay; Receptors, Opioid, mu; Stereoisomerism; Structure-Activity Relationship

2015
Accumulation of cGMP in striatum of rats injected with narcotic analgesics: antagonism by naltrexone.
    The Journal of pharmacy and pharmacology, 1976, Volume: 28, Issue:3

    Topics: Analgesics, Opioid; Animals; Corpus Striatum; Cyclic GMP; Isomerism; Kinetics; Male; Naloxone; Naltrexone; Rats; Time Factors

1976
Behavioral effects of narcotic analgesics administered alone or in combination with narcotic antagonists.
    Proceedings of the Western Pharmacology Society, 1976, Volume: 19

    Topics: Analgesics, Opioid; Animals; Avoidance Learning; Behavior, Animal; Drug Interactions; Electroshock; Haplorhini; Macaca fascicularis; Methadone; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Time Factors

1976
Development of Chronomers for narcotic antagonists.
    National Institute on Drug Abuse research monograph series, 1975, Issue:4

    Topics: Animals; Biodegradation, Environmental; Drug Implants; Hydrogen-Ion Concentration; Kinetics; Morphine; Naloxone; Naltrexone; Polymers; Rats; Reaction Time

1975
Drug release from o/w/o multiple emulsion systems.
    Acta pharmaceutica Suecica, 1978, Volume: 15, Issue:2

    Topics: Emulsions; Hydrogen-Ion Concentration; Naloxone; Naltrexone; Technology, Pharmaceutical; Thymol

1978
Opiate-receptor mediated changes in monoamine synthesis in rat brain.
    The Journal of pharmacy and pharmacology, 1978, Volume: 30, Issue:10

    Topics: Animals; Behavior, Animal; Biogenic Amines; Brain; Catalepsy; Endorphins; Humans; Injections, Intraventricular; Male; Morphine; Naloxone; Naltrexone; Rats; Receptors, Opioid; Time Factors

1978
Analeptic and antianaleptic effects of naloxone and naltrexone in rabbits.
    Life sciences, 1978, Oct-23, Volume: 23, Issue:16

    Topics: Amphetamine; Anesthesia; Animals; Central Nervous System Stimulants; Male; Motor Activity; Naloxone; Naltrexone; Pentobarbital; Rabbits; Reflex; Thyrotropin-Releasing Hormone; Time Factors

1978
Letter: Treatment of accidental naltrexone-induced withdrawal.
    The American journal of psychiatry, 1976, Volume: 133, Issue:2

    Topics: Adult; Humans; Hydromorphone; Male; Methadone; Naloxone; Naltrexone; Substance Withdrawal Syndrome

1976
Naltrexone in a behavioral treatment program.
    NIDA research monograph, 1976, Issue:9

    Topics: Behavior; Conditioning, Psychological; Extinction, Psychological; Humans; Hydromorphone; Injections; Naloxone; Naltrexone; Remission, Spontaneous; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors

1976
Orientation of the oxygen atom at C-6 as a determinant of agonistic activity in the oxymorphone series.
    The Journal of pharmacology and experimental therapeutics, 1977, Volume: 200, Issue:3

    Topics: Animals; Guinea Pigs; Hydromorphone; Male; Naloxone; Naltrexone; Narcotic Antagonists; Oxygen; Oxymorphone; Structure-Activity Relationship

1977
Chloroxymorphamine, and opioid receptor site-directed alkylating agent having narcotic agonist activity.
    Science (New York, N.Y.), 1979, Apr-20, Volume: 204, Issue:4390

    Topics: Alkylating Agents; Animals; Chlorambucil; Dose-Response Relationship, Drug; Drug Synergism; Guinea Pigs; Hydromorphone; In Vitro Techniques; Morphine; Naloxone; Naltrexone; Nitrogen Mustard Compounds; Norepinephrine; Oxymorphone; Phenoxybenzamine; Receptors, Opioid

1979
Unreinforced self-injections: effects on rituals and outcome in heroin addicts.
    NIDA research monograph, 1979, Volume: 27

    Topics: Extinction, Psychological; Follow-Up Studies; Heroin Dependence; Humans; Hydromorphone; Male; Naloxone; Naltrexone; Reinforcement, Psychology; Research Design; Self Administration

1979
Historical trends in naltrexone research.
    NIDA research monograph, 1978, Issue:19

    Topics: Heroin Dependence; History, 20th Century; Humans; Naloxone; Naltrexone; Research; United States

1978
Naltrexone: the clinical investigator's dilemma.
    NIDA research monograph, 1978, Issue:19

    Topics: Adolescent; Adult; Heroin Dependence; Humans; Male; Methadone; Naloxone; Naltrexone; Patient Dropouts; Research Design; Social Adjustment; United States

1978
The future of naltrexone.
    NIDA research monograph, 1978, Issue:19

    Topics: Adolescent; Adult; Endorphins; Female; Forecasting; Heroin Dependence; Humans; Male; Naloxone; Naltrexone; Patient Compliance; United States

1978
Evidence for a mutagenic effect of the narcotic antagonist, naltrexone, in germ cells of Drosophila.
    Mutation research, 1979, Volume: 66, Issue:2

    Topics: Animals; Drosophila melanogaster; Drug Evaluation, Preclinical; Female; Genes, Lethal; Genes, Recessive; Male; Mutagens; Naloxone; Naltrexone; Spermatozoa; X Chromosome

1979
Plasma naltrexone kinetics after intravenous bolus administration in dogs and monkeys.
    Journal of pharmaceutical sciences, 1979, Volume: 68, Issue:4

    Topics: Animals; Chromatography, Gas; Dogs; Female; Haplorhini; Hydrolysis; Injections, Intravenous; Kinetics; Male; Mass Spectrometry; Models, Biological; Naloxone; Naltrexone

1979
Opiate antagonists can inhibit mammary tumor growth in rats.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1979, Volume: 161, Issue:1

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenocarcinoma; Animals; Endorphins; Female; Mammary Neoplasms, Experimental; Naloxone; Naltrexone; Rats

1979
Prevention by naltrexone of tolerance to the rate-decreasing effects of morphine on schedule-controlled responding in the pigeon.
    Psychopharmacology, 1979, May-08, Volume: 63, Issue:1

    Topics: Animals; Columbidae; Conditioning, Operant; Drug Tolerance; Male; Morphine; Naloxone; Naltrexone; Reinforcement Schedule; Time Factors

1979
Naltrexone and behavior therapy for heroin addiction.
    NIDA research monograph, 1979, Issue:25

    Topics: Adult; Behavior Therapy; California; Dose-Response Relationship, Drug; Ethnicity; Follow-Up Studies; Heroin; Heroin Dependence; Humans; Naloxone; Naltrexone

1979
Naltrexone, 6 beta-naltrexol and 2-hydroxy-3-methoxy-6 beta-naltrexol plasma levels in schizophrenic patients after large oral doses of naltrexone.
    NIDA research monograph, 1979, Volume: 27

    Topics: Humans; Middle Aged; Naloxone; Naltrexone; Schizophrenia

1979
Heroin and naltrexone effects on pituitary-gonadal hormones in man: tolerance and supersensitivity.
    NIDA research monograph, 1979, Volume: 27

    Topics: Adult; Heroin; Heroin Dependence; Humans; Luteinizing Hormone; Male; Naloxone; Naltrexone; Prolactin; Testosterone

1979
Modification of treatment compliance as a function of contingent payment manipulations.
    NIDA research monograph, 1979, Volume: 27

    Topics: Adult; Heroin Dependence; Humans; Naloxone; Naltrexone; Patient Compliance; Reinforcement, Psychology

1979
Genetic screening of compounds used in drug abuse treatment. I. Naltrexone hydrochloride.
    Drug and chemical toxicology, 1978, Volume: 1, Issue:2

    Topics: Animals; Bacteria; Bone Marrow Cells; Cells, Cultured; In Vitro Techniques; Mice; Mice, Inbred ICR; Microsomes, Liver; Mutagens; Naloxone; Naltrexone; Neurospora crassa; Rats; Yeasts

1978
The clinical usefulness of narcotic antagonists: implications of behavioral research.
    The American journal of drug and alcohol abuse, 1975, Volume: 2, Issue:3-4

    Topics: Aftercare; Behavior Therapy; Conditioning, Operant; Cyclazocine; Extinction, Psychological; Heroin; Heroin Dependence; Hospitalization; Humans; Methadone; Naloxone; Naltrexone; Narcotic Antagonists; Patient Dropouts; Reinforcement, Psychology; Research Design; Self-Assessment

1975
Analysis and modification of opiate reinforcement.
    The International journal of the addictions, 1976, Volume: 11, Issue:3

    Topics: Adult; Aftercare; Behavior Therapy; Boston; Cyclazocine; Follow-Up Studies; Heroin Dependence; Humans; Male; Middle Aged; Naloxone; Naltrexone; Narcotic Antagonists; Patient Dropouts; Reinforcement, Psychology; Token Economy

1976
Opiate antagonists and the modification of heroin self-administration behavior in man: an experimental study.
    The International journal of the addictions, 1976, Volume: 11, Issue:3

    Topics: Adult; Aftercare; Behavior Therapy; Boston; Conditioning, Operant; Evaluation Studies as Topic; Heroin Dependence; Humans; Male; Middle Aged; Naloxone; Naltrexone; Narcotic Antagonists; Research Design; Satiation; Token Economy

1976
Naltrexone-induced hypothermia in the rat.
    European journal of pharmacology, 1976, Volume: 39, Issue:2

    Topics: Animals; Body Temperature Regulation; Dose-Response Relationship, Drug; Humans; Hypothermia; Morphine; Naloxone; Naltrexone; Placebos; Rats; Receptors, Opioid; Substance Withdrawal Syndrome; Substance-Related Disorders

1976
A method for site selectivity analysis applied to opiate receptors.
    European journal of pharmacology, 1976, Volume: 40, Issue:2

    Topics: Animals; In Vitro Techniques; Morphine Derivatives; Naloxone; Naltrexone; Rats; Receptors, Opioid

1976
Naltrexone in the management of heroin addiction: critique of the rationale.
    NIDA research monograph, 1976, Issue:9

    Topics: Conditioning, Psychological; Heroin Dependence; Humans; Impulsive Behavior; Motivation; Naloxone; Naltrexone; Peptides; Receptors, Opioid

1976
The effects of naltrexone in the chronic spinal dog and acute spinal cat; possible interaction with naturally-occurring morphine-like agonists.
    NIDA research monograph, 1976, Issue:9

    Topics: Animals; Brain; Cats; Cyclazocine; Dogs; Drug Interactions; Morphine Derivatives; Nalorphine; Naloxone; Naltrexone; Receptors, Opioid; Spinal Cord

1976
Endogenous opiate receptor ligand: electrically induced release in the guinea pig ileum.
    Science (New York, N.Y.), 1977, Jan-28, Volume: 195, Issue:4276

    Topics: Electric Stimulation; Ileum; Ligands; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Nerve Tissue Proteins; Neuromuscular Junction; Peptides; Receptors, Opioid; Stereoisomerism

1977
Behavioural dissociation of the enkephalinergic systems of nucleus accumbens and nucleus caudatus.
    Neuropharmacology, 1977, Volume: 16, Issue:5

    Topics: Animals; Brain; Caudate Nucleus; Enkephalins; Globus Pallidus; Male; Morphine; Naloxone; Naltrexone; Olfactory Bulb; Oligopeptides; Rats; Receptors, Opioid; Stereotaxic Techniques

1977
Opioid peptides and opiates differ in receptor selectivity.
    Psychoneuroendocrinology, 1977, Volume: 2, Issue:1

    Topics: Animals; Brain; Dextrorphan; Endorphins; Enkephalins; Isomerism; Levorphanol; Methadone; Morphine; Naloxone; Naltrexone; Rats; Receptors, Opioid

1977
[Receptor occupation and pharmacological activity as demonstrated on opiates (author's transl)].
    Arzneimittel-Forschung, 1977, Volume: 27, Issue:96

    Topics: Animals; Binding Sites; Endorphins; Mice; Naloxone; Naltrexone; Receptors, Opioid; Tritium

1977
Stimulus effects of delta(9)-THC and its interaction with naltrexone and catecholamine blockers in rats.
    Psychopharmacology, 1977, Oct-20, Volume: 54, Issue:2

    Topics: Animals; Catecholamines; Columbidae; Dronabinol; Drug Interactions; Injections, Intraperitoneal; Male; Naloxone; Naltrexone; Rats; Receptors, Adrenergic, alpha

1977
Methadone maintenance and narcotic blocking drugs.
    The International journal of the addictions, 1977, Volume: 12, Issue:7

    Topics: Aftercare; Cyclazocine; Extinction, Psychological; Heroin Dependence; Hospitalization; Humans; Levallorphan; Methadone; Nalorphine; Naloxone; Naltrexone; Narcotic Antagonists; Psychotherapy; Receptors, Opioid

1977
Regulation of prolactin release by endogenous opiates.
    Nature, 1977, Nov-24, Volume: 270, Issue:5635

    Topics: Animals; Endorphins; Female; Hypothalamus; Male; Naloxone; Naltrexone; Pituitary Gland; Prolactin; Rats; Receptors, Opioid

1977
6beta-[N,N-Bis(2-chloroethyl)amino]-17-(cyclopropylmethyl)-4,5alpha-epoxy-3,14-dihydroxymorphinan(chlornaltrexamine) a potent opioid receptor alkylating agent with ultralong narcotic antagonist actitivty.
    Journal of medicinal chemistry, 1978, Volume: 21, Issue:7

    Topics: Alkylating Agents; Analgesia; Binding, Competitive; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Nitrogen Mustard Compounds; Receptors, Opioid

1978
Phospholipid changes in synaptic membranes by lipolytic enzymes and subsequent restoration of opiate binding with phosphatidylserine.
    Biochimica et biophysica acta, 1978, Jul-25, Volume: 530, Issue:1

    Topics: Animals; Carboxy-Lyases; Dihydromorphine; Naloxone; Naltrexone; Phosphatidylethanolamines; Phosphatidylserines; Phospholipases; Phospholipids; Rats; Receptors, Opioid; Structure-Activity Relationship; Synaptic Membranes

1978
Permanent alterations of central opiate systems as a result of chronic opiate antagonism during infancy in rats.
    Proceedings of the Western Pharmacology Society, 1978, Volume: 21

    Topics: Animals; Animals, Newborn; Drinking Behavior; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Receptors, Opioid; Time Factors

1978
Synthesis and pharmacologic characterization of an alkylating analogue (chlornaltrexamine) of naltrexone with ultralong-lasting narcotic antagonist properties.
    Journal of medicinal chemistry, 1979, Volume: 22, Issue:2

    Topics: Alkylating Agents; Analgesics; Animals; Humans; In Vitro Techniques; Male; Mice; Molecular Conformation; Morphine; Morphine Dependence; Naloxone; Naltrexone; Narcotic Antagonists; Nitrogen Mustard Compounds; Rats; Receptors, Opioid; Time Factors

1979
A history of the development of narcotic antagonists for the treatment of narcotic addiction.
    NIDA research monograph, 1978, Issue:19

    Topics: Animals; Cyclazocine; Drug Tolerance; Euphoria; Humans; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Receptors, Opioid; Substance-Related Disorders

1978
Update of naltrexone treatment.
    NIDA research monograph, 1978, Issue:19

    Topics: Adult; Conditioning, Psychological; Female; Humans; Male; Methadone; Naloxone; Naltrexone; Narcotics; Receptors, Opioid; Social Adjustment; Substance Withdrawal Syndrome; Substance-Related Disorders

1978
Naltrexone in the treatment of opiate dependence.
    NIDA research monograph, 1978, Issue:19

    Topics: Adolescent; Adult; Follow-Up Studies; Forecasting; Heroin Dependence; Humans; Male; Methadone; Naloxone; Naltrexone; Narcotics; New York City; Psychotherapy; Receptors, Opioid; Recurrence; Substance Withdrawal Syndrome; Substance-Related Disorders

1978
The development of sustained action preparations of narcotic antagonists.
    NIDA research monograph, 1978, Issue:19

    Topics: Animals; Delayed-Action Preparations; Drug Implants; Humans; Naloxone; Naltrexone; Narcotics; Receptors, Opioid; Research Design; Substance-Related Disorders

1978
Naloxone and naltrexone: actions and interactions at an opiate drug receptor on frog skeletal muscle fibers.
    The Journal of pharmacology and experimental therapeutics, 1979, Volume: 209, Issue:3

    Topics: Action Potentials; Animals; Anura; Electrodes; In Vitro Techniques; Membrane Potentials; Muscles; Naloxone; Naltrexone; Potassium; Rana pipiens; Receptors, Opioid

1979
Research and development of naltrexone: a new narcotic antagonist.
    The American journal of psychiatry, 1979, Volume: 136, Issue:6

    Topics: Financing, Government; Heroin Dependence; Humans; Legislation, Drug; Naloxone; Naltrexone; Receptors, Opioid; Research; United States

1979
Hormonal and other effects of naltrexone in normal men.
    Advances in experimental medicine and biology, 1979, Volume: 116

    Topics: Adrenocorticotropic Hormone; Adult; Body Temperature; Humans; Hydrocortisone; Luteinizing Hormone; Male; Naloxone; Naltrexone; Pain; Prolactin; Respiration; Testosterone

1979
Alterations in brain opiate receptors in Parkinson's disease.
    Brain research, 1979, Sep-14, Volume: 173, Issue:2

    Topics: Aged; Caudate Nucleus; Corpus Striatum; Dopamine; Humans; Middle Aged; Naloxone; Naltrexone; Parkinson Disease; Putamen; Receptors, Dopamine; Receptors, Opioid

1979
Psychiatric implications of endorphin research.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 135

    Topics: Animals; Avoidance Learning; Behavior, Animal; Chronic Disease; Endorphins; Humans; Mental Disorders; Naloxone; Naltrexone; Rats; Receptors, Opioid; Schizophrenia

1979
A gas-liquid chromatographic method for the determination of naltrexone and beta-naltrexol in human urine.
    Journal of chromatography, 1975, Aug-20, Volume: 111, Issue:1

    Topics: Chromatography, Gas; Chromatography, High Pressure Liquid; Etorphine; Hot Temperature; Humans; Hydrogen-Ion Concentration; Naloxone; Naltrexone; Solvents

1975
Clinical outcome with naltrexone.
    Annals of the New York Academy of Sciences, 1978, Volume: 311

    Topics: Follow-Up Studies; Humans; Male; Naloxone; Naltrexone; Substance-Related Disorders; Time Factors

1978
Analgesia to pain stimuli in schizophrenics and its reversal by naltrexone.
    Psychiatry research, 1979, Volume: 1, Issue:1

    Topics: Adult; Electric Stimulation; Evoked Potentials; Female; Humans; Male; Naloxone; Naltrexone; Pain; Schizophrenia

1979
Endogenous opioids participate in the regulation of the hypothalamus-pituitary-luteinizing hormone axis and testosterone's negative feedback control of luteinizing hormone.
    Endocrinology, 1979, Volume: 104, Issue:5

    Topics: Animals; Dose-Response Relationship, Drug; Endorphins; Gonadotropin-Releasing Hormone; Hypothalamo-Hypophyseal System; Luteinizing Hormone; Male; Morphine; Naloxone; Naltrexone; Pituitary Gland; Rats; Testosterone

1979
Failure of beta-endorphin antiserum, naloxone, and naltrexone to alter physiologic growth hormone and insulin secretion.
    Life sciences, 1979, Dec-03, Volume: 25, Issue:23

    Topics: Animals; Antibodies; Camelus; Endorphins; Growth Hormone; Immune Sera; Insulin; Insulin Secretion; Male; Naloxone; Naltrexone; Rats; Time Factors

1979
Continuous intravenous naltrexone effects on morphine self-administration in rhesus monkeys.
    The Journal of pharmacology and experimental therapeutics, 1978, Volume: 204, Issue:2

    Topics: Animals; Dose-Response Relationship, Drug; Haplorhini; Infusions, Parenteral; Macaca mulatta; Morphine; Naloxone; Naltrexone; Self Administration; Time Factors

1978
Withdrawal from endogenous opiates.
    The American journal of psychiatry, 1979, Volume: 136, Issue:3

    Topics: Endorphins; Humans; Naloxone; Naltrexone; Schizophrenia; Substance Withdrawal Syndrome

1979
Endogenous opioid peptides and the control of pain.
    Psychological medicine, 1979, Volume: 9, Issue:1

    Topics: Analgesia; Animals; Cats; Central Nervous System; Endorphins; Humans; Naloxone; Naltrexone; Pain; Spinal Cord; Substance P; Swine

1979
Naltrexone antagonism of exploration in the rat.
    The International journal of neuroscience, 1979, Volume: 9, Issue:1

    Topics: Animals; Depression, Chemical; Dose-Response Relationship, Drug; Endorphins; Exploratory Behavior; Male; Motor Activity; Naloxone; Naltrexone; Rats

1979
Nitrous oxide stimulation of locomotor activity: evidence for an opiate-like behavioral effect.
    The Journal of pharmacology and experimental therapeutics, 1979, Volume: 209, Issue:2

    Topics: Adaptation, Psychological; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Male; Mice; Morphine; Motor Activity; Naloxone; Naltrexone; Narcotics; Nitrous Oxide

1979
Evidence supporting lack of discriminative stimulus properties of a combination of naltrexone and morphine.
    Pharmacology, biochemistry, and behavior, 1979, Volume: 10, Issue:4

    Topics: Animals; Discrimination, Psychological; Drug Interactions; Generalization, Stimulus; Gerbillinae; Male; Morphine; Naloxone; Naltrexone

1979
Facilitation by opiate antagonists of sexual performance in the male rat.
    Pharmacology, biochemistry, and behavior, 1979, Volume: 10, Issue:4

    Topics: Animals; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Sexual Behavior, Animal; Stimulation, Chemical; Time Factors

1979
Comparison of binding of [3H]-methionine-enkephalin, [3H]-naltrexone and [3H]-dihydromorphine in the mouse vas deferens and the myenteric plexus and brain of the ginea pig.
    European journal of pharmacology, 1979, Jul-01, Volume: 56, Issue:4

    Topics: Animals; Brain; Dihydromorphine; Endorphins; Enkephalins; Guinea Pigs; In Vitro Techniques; Male; Mice; Morphine Derivatives; Myenteric Plexus; Naloxone; Naltrexone; Organ Specificity; Stereoisomerism; Vas Deferens

1979
Acute effects of opiate agonists, partial agonists and antagonists on brain monoamines in the rat.
    Archives internationales de pharmacodynamie et de therapie, 1979, Volume: 238, Issue:1

    Topics: Animals; Behavior, Animal; Biogenic Amines; Brain Chemistry; Cyclazocine; Dextrorphan; Female; Levallorphan; Morphine; Nalorphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pentazocine; Rats

1979
Studies of the possible role of brain endorphins in pentobarbital anesthesia and toxicity in mice.
    Anesthesiology, 1979, Volume: 51, Issue:5

    Topics: Animals; Brain; Endorphins; Enkephalins; Leucine; Male; Mice; Morphine; Naloxone; Naltrexone; Pentobarbital; Phenylalanine

1979
Enhanced analgesic effects of stress following chronic administration of naltrexone in rats.
    European journal of pharmacology, 1979, Oct-26, Volume: 59, Issue:1-2

    Topics: Analgesia; Animals; Male; Naloxone; Naltrexone; Rats; Reaction Time; Stress, Physiological; Time Factors

1979
Plasma and semen kinetics of naltrexone in the rabbit.
    Proceedings of the Western Pharmacology Society, 1979, Volume: 22

    Topics: Animals; Half-Life; Kinetics; Male; Naloxone; Naltrexone; Rabbits; Semen

1979
Increased amphetamine potency following chronic naltrexone administration in rats.
    Life sciences, 1979, Oct-15, Volume: 25, Issue:16

    Topics: Animals; Apomorphine; Dextroamphetamine; Drug Synergism; Male; Motor Activity; Naloxone; Naltrexone; Rats; Time Factors

1979
Inhibition of drug metabolism by chronically administered naltrexone.
    Life sciences, 1979, Oct-29, Volume: 25, Issue:18

    Topics: Animals; Cytochrome P-450 Enzyme System; Depression, Chemical; Drug Implants; Liver; Male; Mice; Mixed Function Oxygenases; Naloxone; Naltrexone; Pharmaceutical Preparations; Time Factors

1979
Suppressant effects of naltrexone on water intake in rats.
    Pharmacology, biochemistry, and behavior, 1979, Volume: 11, Issue:4

    Topics: Animals; Body Weight; Depression, Chemical; Drinking Behavior; Female; Naloxone; Naltrexone; Pain; Quinine; Rats; Self Administration; Sensory Thresholds; Time Factors; Water Deprivation

1979
Effects of contingent payment on compliance with a naltrexone regimen.
    The American journal of drug and alcohol abuse, 1979, Volume: 6, Issue:3

    Topics: Adult; Behavior Therapy; Consumer Behavior; Heroin Dependence; Humans; Length of Stay; Male; Naloxone; Naltrexone; Patient Compliance; Reinforcement Schedule

1979
Behavioral effects of perinatal naltrexone exposure: a preliminary investigation.
    Pharmacology, biochemistry, and behavior, 1979, Volume: 11 Suppl

    Topics: Analgesics; Animals; Animals, Newborn; Behavior, Animal; Conditioning, Operant; Electroshock; Emotions; Female; Morphine; Motor Activity; Naloxone; Naltrexone; Pregnancy; Rats; Reaction Time

1979
Chronic naltrexone administration reverses the suppressive effect of crowding on body weight gain in rats.
    Neuropharmacology, 1979, Volume: 18, Issue:11

    Topics: Animals; Body Weight; Crowding; Male; Naloxone; Naltrexone; Rats; Time Factors

1979
Differentiation between opioid peptides by naltrexone.
    European journal of pharmacology, 1977, Oct-15, Volume: 45, Issue:4

    Topics: Animals; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Naloxone; Naltrexone; Peptides; Vas Deferens

1977
The pharmacology of thebaine in the chronic spinal dog.
    Drug and alcohol dependence, 1978, Volume: 3, Issue:2

    Topics: Animals; Dogs; Humans; Naloxone; Naltrexone; Spinal Cord; Substance Withdrawal Syndrome; Substance-Related Disorders; Thebaine; Time Factors

1978
The effects of naltrexone on the development of physical dependence on morphine.
    European journal of pharmacology, 1978, Aug-01, Volume: 50, Issue:3

    Topics: Animals; Behavior, Animal; Body Temperature; Brain; Drug Implants; Humans; Male; Mice; Morphine; Morphine Dependence; Naloxone; Naltrexone; Time Factors

1978
Discriminative stimulus effects of naltrexone in the morphine-dependent rat.
    The Journal of pharmacology and experimental therapeutics, 1979, Volume: 211, Issue:3

    Topics: Animals; Generalization, Stimulus; Humans; Male; Morphine; Morphine Dependence; Naloxone; Naltrexone; Narcotic Antagonists; Prejudice; Rats; Substance Withdrawal Syndrome; Time Factors

1979
Prospects, problems, side effects, and safety of narcotic antagonists.
    The International journal of the addictions, 1977, Volume: 12, Issue:7

    Topics: Cyclazocine; Delayed-Action Preparations; Humans; Naloxone; Naltrexone; Psychotherapy; Reinforcement, Social

1977
Possible withdrawal from endogeneous opiates in schizophrenics.
    The American journal of psychiatry, 1978, Volume: 135, Issue:3

    Topics: Female; Humans; Male; Naloxone; Naltrexone; Schizophrenia; Substance Withdrawal Syndrome; Time Factors

1978
Prlonged drug release from multiple emulsions.
    Acta pharmaceutica Suecica, 1978, Volume: 15, Issue:1

    Topics: Delayed-Action Preparations; Emulsions; Half-Life; Naloxone; Naltrexone; Technology, Pharmaceutical

1978
Inhibition by d,l-methadone of RNA and protein synthesis in neonatal mice: antagonism by naloxone or naltrexone.
    European journal of pharmacology, 1978, May-01, Volume: 49, Issue:1

    Topics: Animals; Animals, Newborn; Depression, Chemical; Liver; Methadone; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Protein Biosynthesis; RNA; Time Factors

1978
Plasma corticosteroid levels in rats maintained on a long-acting naltrexone delivery system.
    Research communications in chemical pathology and pharmacology, 1978, Volume: 20, Issue:1

    Topics: Adrenal Cortex Hormones; Animals; Drug Implants; Male; Morphine; Naloxone; Naltrexone; Rats; Reaction Time; Time Factors

1978
Stereospecific aversive property of narcotic antagonists in morphine-free rats.
    Life sciences, 1978, May-15, Volume: 22, Issue:19

    Topics: Animals; Avoidance Learning; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Stereoisomerism; Structure-Activity Relationship

1978
The identification and measurement of two new metabolites of naltrexone in human urine.
    Research communications in chemical pathology and pharmacology, 1978, Volume: 20, Issue:3

    Topics: Animals; Chromatography, Gas; Half-Life; Humans; Male; Mass Spectrometry; Naloxone; Naltrexone; Rats

1978
Naltrexone, morphine and cocaine interactions in mice and rats.
    The Journal of pharmacology and experimental therapeutics, 1978, Volume: 206, Issue:2

    Topics: Animals; Cocaine; Drug Interactions; Lethal Dose 50; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Reaction Time; Reflex

1978
Effects of repeated injections of naltrexone on antagonism of rate decreases by morphine in the pigeon.
    Pharmacology, biochemistry, and behavior, 1978, Volume: 9, Issue:2

    Topics: Animals; Behavior, Animal; Columbidae; Conditioning, Operant; Male; Morphine; Naloxone; Naltrexone; Time Factors

1978
Narcotic antagonist treatment: clinical experience with naltrexone.
    The International journal of the addictions, 1978, Volume: 13, Issue:6

    Topics: Adolescent; Adult; Attitude; Drug Evaluation; Emotions; Employment; Follow-Up Studies; Heroin Dependence; Humans; Male; Middle Aged; Naloxone; Naltrexone; Patient Compliance; Psychiatric Status Rating Scales; Time Factors

1978
Discriminative effects of morphine in the pigeon.
    Pharmacology, biochemistry, and behavior, 1978, Volume: 9, Issue:4

    Topics: Animals; Columbidae; Dextrorphan; Discrimination, Psychological; Generalization, Psychological; Humans; Levorphanol; Morphine; Naloxone; Naltrexone; Time Factors

1978
Carbon-13 nuclear magnetic resonance identification of 2-hydroxy-3-O-methyl-6beta-naltrexol as a minor naltrexone metabolite.
    Research communications in chemical pathology and pharmacology, 1978, Volume: 22, Issue:3

    Topics: Adult; Humans; Magnetic Resonance Spectroscopy; Male; Naloxone; Naltrexone

1978
Naltrexone and conventionality.
    The American journal of drug and alcohol abuse, 1978, Volume: 5, Issue:2

    Topics: Adolescent; Adult; Crime; Drug Evaluation; Economics; Employment; Heroin Dependence; Humans; Life Style; Male; Marriage; Middle Aged; Naloxone; Naltrexone; Patient Compliance; Residence Characteristics; Social Conformity

1978
Craving in heroin addicts maintained on the opiate antagonist naltrexone.
    The American journal of drug and alcohol abuse, 1978, Volume: 5, Issue:4

    Topics: Heroin Dependence; Humans; Naloxone; Naltrexone; Patient Dropouts

1978
Alteration of ethanol effects by opiate antagonists.
    Currents in alcoholism, 1979, Volume: 5

    Topics: Animals; Body Temperature; Calcium; Drug Interactions; Ethanol; Fasting; Female; Lethal Dose 50; Male; Mice; Motor Activity; Naloxone; Naltrexone; Rats; Reflex; Sleep; Species Specificity

1979
Pharmacokinetics of naloxone and naltrexone in the dog.
    The Journal of pharmacology and experimental therapeutics, 1979, Volume: 208, Issue:2

    Topics: Animals; Dogs; Female; Half-Life; Kinetics; Male; Naloxone; Naltrexone; Radioimmunoassay

1979
Development of polylactic/glycolic acid delivery systems for use in treatment of narcotic addiction.
    National Institute on Drug Abuse research monograph series, 1976, Issue:4

    Topics: Animals; Drug Implants; Foreign-Body Reaction; Lactates; Male; Mice; Morphine; Naloxone; Naltrexone; Polyglycolic Acid; Polymers; Reaction Time; Time Factors

1976
Naltrexone bibliography.
    NIDA research monograph, 1976, Issue:9

    Topics: Bibliographies as Topic; Naloxone; Naltrexone

1976
Metabolic reduction of naltrexone. I. Synthesis, separation and characterization of naloxone and naltrexone reduction products and qualitative assay of urine and bile following administration of naltrexone, alpha-naltrexol, or beta-naltrexol.
    Research communications in chemical pathology and pharmacology, 1975, Volume: 12, Issue:1

    Topics: Animals; Bile; Chromatography, Gas; Chromatography, Thin Layer; Circular Dichroism; Dogs; Guinea Pigs; Haplorhini; Humans; Magnetic Resonance Spectroscopy; Mice; Naloxone; Naltrexone; Optical Rotation; Oxidation-Reduction; Rats; Stereoisomerism

1975
Tritiated naltrexone binding in plasma from several species and tissue distribution in mice.
    Journal of pharmaceutical sciences, 1976, Volume: 65, Issue:5

    Topics: Animals; Dogs; Female; Guinea Pigs; Haplorhini; Humans; Macaca mulatta; Male; Mice; Naloxone; Naltrexone; Rats; Species Specificity; Time Factors

1976
Assessment of CNS drug activity in rhesus monkeys by analysis of the EEG.
    Federation proceedings, 1976, Volume: 35, Issue:11

    Topics: Amobarbital; Animals; Brain; Clorazepate Dipotassium; Codeine; Computers; Electroencephalography; Glutethimide; Haplorhini; Macaca mulatta; Morphine; Nalbuphine; Naloxone; Naltrexone

1976
[Precipitation and prevention of abstinence in acutely morphinized rats and mice: comparisons between naloxone, naltrexone, and diprenorphine (author's transl)].
    Psychopharmacology, 1976, Aug-26, Volume: 49, Issue:1

    Topics: Animals; Diprenorphine; Humans; Male; Mice; Morphinans; Morphine; Morphine Dependence; Naloxone; Naltrexone; Rats; Substance Withdrawal Syndrome; Time Factors

1976
Metabolic reduction of naltrexone II. In vitro studies using liver from guinea pig, monkey and rat.
    Research communications in chemical pathology and pharmacology, 1976, Volume: 14, Issue:3

    Topics: Animals; Guinea Pigs; Haplorhini; In Vitro Techniques; Isomerism; Liver; Macaca mulatta; Male; Naloxone; Naltrexone; Oxidation-Reduction; Rats; Species Specificity; Subcellular Fractions

1976
Blockade of the discriminative effects of morphine in the rat by naltrexone and naloxone.
    Psychopharmacology, 1976, Nov-10, Volume: 50, Issue:2

    Topics: Administration, Oral; Animals; Cues; Discrimination, Psychological; Dose-Response Relationship, Drug; Injections, Subcutaneous; Male; Morphine; Naloxone; Naltrexone; Rats; Time Factors

1976
Testing of drug delivery systems for use in the treatment of narcotic addiction.
    National Institute on Drug Abuse research monograph series, 1975, Issue:4

    Topics: Animals; Blood Proteins; Dogs; Drug Implants; Guinea Pigs; Haplorhini; Humans; Kinetics; Mice; Morphine; Naloxone; Naltrexone; Protein Binding; Rats; Reaction Time; Species Specificity; Substance-Related Disorders

1975
Evaluation of narcotic and narcotic antagonist interactions in primates.
    Annals of the New York Academy of Sciences, 1976, Volume: 281

    Topics: Animals; Cyclazocine; Dextroamphetamine; Diazepam; Drug Interactions; Ethanol; Female; Haplorhini; Humans; Macaca mulatta; Male; Methadone; Methadyl Acetate; Morphine; Morphine Dependence; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Phenytoin; Secobarbital; Self Administration

1976
The effect of the narcotic antagonists naloxone, naltrexone and nalorphine on spinal cord C-fiber reflexes evoked by electrical stimulation or radiant heat.
    European journal of pharmacology, 1977, Mar-21, Volume: 42, Issue:2

    Topics: Action Potentials; Animals; Cats; Decerebrate State; Electric Stimulation; Hot Temperature; Nalorphine; Naloxone; Naltrexone; Reflex; Spinal Cord; Time Factors

1977
Naloxone-precipitated withdrawal: a method for rapid induction onto naltrexone.
    Clinical pharmacology and therapeutics, 1977, Volume: 21, Issue:4

    Topics: Adult; Drug Administration Schedule; Drug Therapy, Combination; Heroin Dependence; Humans; Male; Methadone; Methods; Naloxone; Naltrexone; Substance Withdrawal Syndrome; Substance-Related Disorders

1977
Antagonism of the effects of pentobarbital in the chronic spinal dog by naltrexone.
    Life sciences, 1977, Apr-15, Volume: 20, Issue:8

    Topics: Animals; Body Temperature; Consciousness; Dogs; Heart Rate; Naloxone; Naltrexone; Pentobarbital; Reflex; Spinal Cord

1977
Naltrexone treatment of opiate-dependent persons.
    Drug and alcohol dependence, 1977, Volume: 2, Issue:3

    Topics: Adult; Humans; Male; Methadone; Middle Aged; Naloxone; Naltrexone; Narcotics; Substance-Related Disorders

1977
Quantitative determination of naltrexone and naltrexone prodrugs by electron-capture gas-liquid chromatography.
    Journal of chromatography, 1977, Jul-21, Volume: 137, Issue:2

    Topics: Chromatography, Gas; Esters; Ethers; Hydrolysis; Naloxone; Naltrexone; Solutions

1977
Stereochemical studies on medicinal agents. 23. Synthesis and biological evaluation of 6-amino derivatives of naloxone and naltrexone.
    Journal of medicinal chemistry, 1977, Volume: 20, Issue:8

    Topics: Amination; Analgesics; Animals; Binding, Competitive; In Vitro Techniques; Male; Mice; Morphine; Naloxone; Naltrexone; Stereoisomerism

1977
Estimation of the systemic availability and other pharmacokinetic parameters of naltrexone in man after acute and chronic oral administration.
    Research communications in chemical pathology and pharmacology, 1977, Volume: 18, Issue:1

    Topics: Administration, Oral; Biological Availability; Half-Life; Humans; Kinetics; Naloxone; Naltrexone; Time Factors

1977
An oral opiate antagonist in chronic schizophrenia: a pilot study.
    The American journal of psychiatry, 1977, Volume: 134, Issue:12

    Topics: Administration, Oral; Adult; Drug Evaluation; Female; Humans; Male; Middle Aged; Naloxone; Naltrexone; Pilot Projects; Schizophrenia

1977
Effects of acute and chronic morphine and narcotic antagonists on brain energy metabolism.
    Life sciences, 1977, Nov-15, Volume: 21, Issue:10

    Topics: Animals; Brain; Citrates; Energy Metabolism; Glucose; Malates; Male; Mice; Morphine; Naloxone; Naltrexone; Pyruvates

1977
Comparison of withdrawal precipitating properties of various morphine antagonists and partial agonists in relation to their stereospecific binding to brain homogenates.
    Psychopharmacologia, 1976, Volume: 46, Issue:1

    Topics: Benzomorphans; Binding Sites; Brain; Humans; Levallorphan; Morphine Dependence; Nalorphine; Naloxone; Naltrexone; Narcotic Antagonists; Pentazocine; Receptors, Drug; Sodium; Stereoisomerism; Subcellular Fractions; Substance Withdrawal Syndrome

1976
A behavioral paradigm for the evaluation of narcotic antagonists.
    Archives of general psychiatry, 1976, Volume: 33, Issue:3

    Topics: Adult; Cyclazocine; Heroin Dependence; Humans; Male; Naloxone; Naltrexone; Narcotic Antagonists; Research Design

1976
Reinstatement of precipitated narcotic withdrawal hypothermia in the rat.
    Life sciences, 1976, Jun-01, Volume: 18, Issue:11

    Topics: Animals; Body Temperature; Female; Humans; Morphine; Naloxone; Naltrexone; Rats; Substance Withdrawal Syndrome; Substance-Related Disorders

1976
Naltrexone: disposition, metabolism, and effects after acute and chronic dosing.
    Clinical pharmacology and therapeutics, 1976, Volume: 20, Issue:3

    Topics: Adult; Drug Administration Schedule; Half-Life; Heroin; Humans; Kinetics; Male; Naloxone; Naltrexone; Pupil; Respiration; Time Factors

1976
The structure-action relationship and kinetics of some naloxone and naltrexone derivatives.
    Pharmacology, 1976, Volume: 14, Issue:1

    Topics: Animals; Cyclazocine; Guinea Pigs; Ileum; Kinetics; Morphine; Morphine Derivatives; Muscle Contraction; Naloxone; Naltrexone; Narcotic Antagonists; Structure-Activity Relationship; Time Factors

1976
Sustained release of naltrexone from glyceride implants.
    National Institute on Drug Abuse research monograph series, 1976, Issue:4

    Topics: Animals; Delayed-Action Preparations; Drug Implants; Glycerides; Male; Mice; Morphine; Naloxone; Naltrexone; Reaction Time; Time Factors

1976
Morphine-naloxone interaction in the central cholinergic system: the influence of subcortical lesioning and electrical stimulation.
    British journal of pharmacology, 1976, Volume: 58, Issue:1

    Topics: Acetylcholine; Animals; Brain; Cerebral Cortex; Drug Interactions; Electric Stimulation; In Vitro Techniques; Morphine; Naloxone; Naltrexone; Parasympathetic Nervous System; Rats; Time Factors

1976
Determination of naloxone and naltrexone as perfluoroalkyl ester derivatives by electron-capture gas-liquid chromatography.
    Journal of chromatography, 1976, Oct-13, Volume: 125, Issue:2

    Topics: Anhydrides; Chromatography, Gas; Chromatography, Liquid; Mass Spectrometry; Naloxone; Naltrexone

1976
Ring C conformation of 6beta-naltrexol and 6alpha-naltrexol. Evidence from proton and carbon-13 nuclear magnetic resonance.
    The Journal of organic chemistry, 1976, Oct-15, Volume: 41, Issue:21

    Topics: Magnetic Resonance Spectroscopy; Molecular Conformation; Naloxone; Naltrexone

1976
Nitrous oxide "analgesia": resemblance to opiate action.
    Science (New York, N.Y.), 1976, Nov-26, Volume: 194, Issue:4268

    Topics: Analgesia; Animals; Drug Tolerance; Mice; Morphine; Naloxone; Naltrexone; Nitrous Oxide

1976
Ethanol preference in the hamster: effects of morphine sulfate and naltrexone, a long-acting morphine antagonist.
    Proceedings of the Western Pharmacology Society, 1976, Volume: 19

    Topics: Alcohol Drinking; Animals; Choice Behavior; Cricetinae; Decision Making; Dextrorphan; Levorphanol; Morphine; Naloxone; Naltrexone; Time Factors

1976
Psychopathology and mood during heroin use: acute vs chronic effects.
    Archives of general psychiatry, 1976, Volume: 33, Issue:12

    Topics: Acute Disease; Adult; Chronic Disease; Dose-Response Relationship, Drug; Drug Therapy, Combination; Emotions; Euphoria; Heroin; Heroin Dependence; Humans; Male; Methadone; Morphine; Motor Activity; Naloxone; Naltrexone; Psychopathology

1976
Short-term effects of naltrexone in 155 heroin ex-addicts.
    Biological psychiatry, 1976, Volume: 11, Issue:6

    Topics: Abdomen; Administration, Oral; Blood Pressure; Brain; Dose-Response Relationship, Drug; Drug Evaluation; Heart; Heroin Dependence; Humans; Naloxone; Naltrexone; Pain; Respiration; Substance-Related Disorders; Time Factors

1976
An analysis of naltrexone use--its efficacy, safety and potential.
    NIDA research monograph, 1976, Issue:9

    Topics: Adult; Drug Administration Schedule; Drug Evaluation; Female; Humans; Male; Methadone; Middle Aged; MMPI; Naloxone; Naltrexone; Outpatient Clinics, Hospital; Patient Compliance; Patient Dropouts; Personality Inventory; Substance-Related Disorders

1976
Interactions of narcotics, narcotic antagonists, and ethanol during acute, chronic, and withdrawal states.
    Annals of the New York Academy of Sciences, 1976, Volume: 281

    Topics: Alcohol Drinking; Animals; Animals, Newborn; Dextrorphan; Drug Interactions; Ethanol; Humans; Levorphanol; Male; Methadone; Methadyl Acetate; Mice; Mice, Inbred C57BL; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors

1976
Clinical efficacy of naltrexone: a one year follow up.
    NIDA research monograph, 1976, Issue:9

    Topics: Adult; Follow-Up Studies; Heroin Dependence; Humans; Naloxone; Naltrexone; Time Factors

1976
Treatment of heroin dependence with naltrexone.
    Current psychiatric therapies, 1975, Volume: 15

    Topics: Heroin Dependence; Humans; Naloxone; Naltrexone

1975
Isolation and identification of a new metabolite of naltrexone in human blood and urine.
    Research communications in chemical pathology and pharmacology, 1975, Volume: 12, Issue:1

    Topics: Adult; Biological Availability; Chromatography, Gas; Chromatography, Thin Layer; Erythrocytes; Humans; Hydroxylation; Mass Spectrometry; Naloxone; Naltrexone; Time Factors

1975
Comparative in vivo distribution of opiate agonists and antagonists by means of double isotope techniques.
    Life sciences, 1975, Oct-10, Volume: 17, Issue:7

    Topics: Animals; Autoradiography; Blood-Brain Barrier; Brain; Carbon Radioisotopes; Dose-Response Relationship, Drug; Liver; Male; Morphine; Naloxone; Naltrexone; Rats; Time Factors; Tritium

1975
Acetylcholine storage and its stabilization by morphine.
    Research communications in chemical pathology and pharmacology, 1975, Volume: 12, Issue:3

    Topics: Acetylcholine; Adenosine Triphosphate; Animals; Chemical Phenomena; Chemistry; In Vitro Techniques; Kinetics; Magnetic Resonance Spectroscopy; Morphine; Naloxone; Naltrexone; Sodium Chloride; Spectrometry, Fluorescence; Synaptosomes

1975
Influence of catecholaminergic agents on narcotic binding in brain.
    Archives internationales de pharmacodynamie et de therapie, 1975, Volume: 218, Issue:2

    Topics: Animals; Brain; Catecholamines; Dopamine; In Vitro Techniques; Kinetics; Male; Naloxone; Naltrexone; Norepinephrine; Rats

1975
On the role of chemotherapy in the treatment of heroin addiction.
    The American journal of drug and alcohol abuse, 1975, Volume: 2, Issue:3-4

    Topics: Heroin Dependence; Humans; Methadone; Methadyl Acetate; Motivation; Naloxone; Naltrexone; Substance-Related Disorders

1975
Naltrexone pharmacology, pharmacokinetics, and metabolism: current status.
    The American journal of drug and alcohol abuse, 1975, Volume: 2, Issue:3-4

    Topics: Administration, Oral; Animals; Biological Availability; Biotransformation; Chickens; Delayed-Action Preparations; Dogs; Drug Evaluation, Preclinical; Guinea Pigs; Half-Life; Heroin Dependence; Humans; Injections, Intravenous; Injections, Subcutaneous; Kinetics; Mice; Naloxone; Naltrexone; Rats; Species Specificity; Time Factors

1975
Clinical experience with naltrexone.
    The American journal of drug and alcohol abuse, 1975, Volume: 2, Issue:3-4

    Topics: Administration, Oral; Adult; Female; Heroin Dependence; Hospitalization; Humans; Male; Methadone; Middle Aged; Morphine; Naloxone; Naltrexone; Outpatient Clinics, Hospital; Patient Dropouts; Placebos; Time Factors

1975
The clinical usefulness of narcotic antagonists: preliminary findings on the use of naltrexone.
    The American journal of drug and alcohol abuse, 1975, Volume: 2, Issue:3-4

    Topics: Adult; Alcoholism; Boston; Cannabis; Depression; Emotions; Follow-Up Studies; Heroin Dependence; Humans; Internal-External Control; Male; Naloxone; Naltrexone; Patient Acceptance of Health Care; Patient Dropouts; Psychotherapy; Self Concept; Sleep

1975
Clinical use of naltrexone (EN 1639 A). Part II: experience with the first 50 patients in a New York City treatment clinic.
    The American journal of drug and alcohol abuse, 1975, Volume: 2, Issue:3-4

    Topics: Administration, Oral; Ambulatory Care; Educational Status; Employment; Ethnicity; Female; Heroin Dependence; Humans; Male; Naloxone; Naltrexone; New York City; Patient Dropouts

1975
Patient deaths in a narcotic antagonist (naltrexone) and l-alpha-acetylmethadol program.
    The American journal of drug and alcohol abuse, 1975, Volume: 2, Issue:3-4

    Topics: Adult; Heroin Dependence; Homicide; Humans; Male; Methadone; Methadyl Acetate; Naloxone; Naltrexone; Psychotropic Drugs; Substance-Related Disorders; Suicide

1975
Naltrexone study guidelines: good vehicle--wrong destination.
    The American journal of drug and alcohol abuse, 1975, Volume: 2, Issue:3-4

    Topics: Drug Evaluation; Heroin Dependence; Humans; Motivation; Naloxone; Naltrexone; Research Design

1975
Sustained release of naltrexone from glyceride implants.
    National Institute on Drug Abuse research monograph series, 1975, Issue:4

    Topics: Animals; Biodegradation, Environmental; Chemistry, Pharmaceutical; Drug Implants; Glycerides; Histocompatibility; Mice; Morphine; Naloxone; Naltrexone; Reaction Time; Time Factors

1975
Use of synthetic polypeptides in the preparation of biodegradable delivery vehicles for narcotic antagonists.
    National Institute on Drug Abuse research monograph series, 1975, Issue:4

    Topics: Animals; Biodegradation, Environmental; Drug Implants; Glutamates; Leucine; Mice; Morphine; Naloxone; Naltrexone; Peptides; Reaction Time; Time Factors

1975
Lactic/glycolic acid polymers as narcotic antagonist delivery systems.
    Life sciences, 1975, Dec-15, Volume: 17, Issue:12

    Topics: Animals; Behavior, Animal; Drug Implants; Glycolates; Humans; In Vitro Techniques; Lactates; Male; Mice; Naloxone; Naltrexone; Polymers; Structure-Activity Relationship; Substance-Related Disorders

1975
Development of polylactic/glycolic acid delivery systems for use in treatment of narcotic addiction.
    National Institute on Drug Abuse research monograph series, 1975, Issue:4

    Topics: Animals; Biodegradation, Environmental; Drug Implants; Humans; Lactates; Male; Mice; Naloxone; Naltrexone; Polyglycolic Acid; Polymers; Substance-Related Disorders; Time Factors

1975
Development of injectable microcapsules for use in the treatment of narcotic addiction.
    National Institute on Drug Abuse research monograph series, 1975, Issue:4

    Topics: Animals; Capsules; Delayed-Action Preparations; Humans; Injections; Lactates; Mice; Microspheres; Naloxone; Naltrexone; Polyglycolic Acid; Polymers; Substance-Related Disorders

1975
Quantitative determination of naltrexone and beta-naltrexol in human plasma using electron detection.
    Journal of chromatography, 1976, Apr-07, Volume: 118, Issue:3

    Topics: Chromatography, Gas; Dose-Response Relationship, Drug; Humans; Naloxone; Naltrexone

1976
Use of narcotic (opiate) antagonists.
    American family physician, 1976, Volume: 13, Issue:3

    Topics: Cyclazocine; Humans; Naloxone; Naltrexone; Narcotic Antagonists

1976
An evaluation of the hot plate technique to study narcotic antagonists.
    Research communications in chemical pathology and pharmacology, 1976, Volume: 13, Issue:4

    Topics: Animals; Male; Methods; Mice; Models, Biological; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Reaction Time; Time Factors

1976
Involvement of opioid mechanisms in peripheral motor control of detrusor muscle.
    Pharmacology & toxicology, 1992, Volume: 71, Issue:3 Pt 1

    Topics: Animals; Electric Stimulation; Enkephalins; Ganglionic Blockers; Hexamethonium; Hexamethonium Compounds; Humans; Indoles; Male; Morphinans; Morphine; Muscle Contraction; Muscles; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Substance P; Sympatholytics

1992
Kappa-/mu-receptor interactions in the opioid control of the in vivo release of substance P-like material from the rat spinal cord.
    Neuroscience, 1992, Volume: 51, Issue:2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Kinetics; Male; Models, Neurological; Naloxone; Naltrexone; Pyrrolidines; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord; Substance P

1992
Perinatal morphine exposure alters peptidergic development in the striatum.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 1992, Volume: 10, Issue:6

    Topics: Animals; Blotting, Northern; Body Weight; Corpus Striatum; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Growth; Immunohistochemistry; In Situ Hybridization; Morphine; Naloxone; Naltrexone; Protein Precursors; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Substance P

1992
Comparison of the neurochemistry of the endogenous opioid systems in two brainstem pain-processing centers.
    Stereotactic and functional neurosurgery, 1992, Volume: 59, Issue:1-4

    Topics: Animals; Brain Stem; Dipeptides; Dose-Response Relationship, Drug; Medulla Oblongata; Microinjections; Naloxone; Naltrexone; Neprilysin; Pain; Periaqueductal Gray; Rats

1992
Erythrocytes as carriers of new anti-opioid prodrugs: in vitro studies.
    Advances in experimental medicine and biology, 1992, Volume: 326

    Topics: Drug Carriers; Drug Stability; Erythrocyte Membrane; Hemolysis; Humans; In Vitro Techniques; Molecular Structure; Naloxone; Naltrexone; Plasma; Prodrugs

1992
Effects of naloxone and nalmefene in rat spinal cord injury induced by the ventral compression technique.
    Journal of spinal disorders, 1992, Volume: 5, Issue:1

    Topics: Animals; Drug Evaluation, Preclinical; Intervertebral Disc Displacement; Naloxone; Naltrexone; Nerve Crush; Paralysis; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Spinal Cord Injuries; Spinal Fractures

1992
A highly selective kappa-opioid receptor agonist, CI-977, reduces excitatory synaptic potentials in the rat locus coeruleus in vitro.
    Neuroscience, 1992, Volume: 47, Issue:1

    Topics: Amino Acids; Analgesics; Animals; Benzofurans; Benzomorphans; Bicuculline; Depression, Chemical; Electric Stimulation; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; In Vitro Techniques; Ligands; Locus Coeruleus; Membrane Potentials; Naloxone; Naltrexone; Picrotoxin; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Synapses

1992
Kappa-opioid receptor stimulation abolishes mu- but not delta-mediated inhibitory control of spinal Met-enkephalin release.
    Neuroscience letters, 1992, Jan-06, Volume: 134, Issue:2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Indoles; Injections, Spinal; Male; Morphinans; Naloxone; Naltrexone; Neurons; Oligopeptides; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord

1992
Kappa opioid mediation of fetal responses to milk.
    Behavioral neuroscience, 1992, Volume: 106, Issue:2

    Topics: Aging; Animals; Arousal; Chemoreceptor Cells; Dose-Response Relationship, Drug; Female; Fetal Movement; Gestational Age; Morphine; Motor Activity; Naloxone; Naltrexone; Pregnancy; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Sucking Behavior; Taste; Touch

1992
Hypothermic effect of D-Ala-deltorphin II, a selective delta opioid receptor agonist.
    Neuroscience letters, 1992, May-25, Volume: 139, Issue:2

    Topics: Animals; Body Temperature; Indoles; Injections, Intraventricular; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta

1992
Naloxone-induced analgesia in diabetic mice.
    European journal of pharmacology, 1992, Jan-21, Volume: 210, Issue:3

    Topics: Analgesia; Animals; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Drug Interactions; Indoles; Injections, Subcutaneous; Male; Mice; Mice, Inbred ICR; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid

1992
Interaction between opioid antagonists and amphetamine: evidence for mediation by central delta opioid receptors.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 262, Issue:2

    Topics: Amphetamine; Analgesia; Animals; Brain; Indoles; Male; Morphinans; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta

1992
Effects of diabetes on stress-induced analgesia in mice.
    Brain research, 1992, May-15, Volume: 580, Issue:1-2

    Topics: Animals; Diabetes Mellitus, Experimental; Male; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Physical Exertion; Receptors, Opioid, mu; Sensory Thresholds; Stress, Physiological

1992
Spinal antinociception by Tyr-D-Ser(otbu)-Gly-Phe-Leu-Thr, a selective delta-opioid receptor agonist.
    European journal of pharmacology, 1992, May-27, Volume: 216, Issue:1

    Topics: Amino Acid Sequence; Analgesics; Animals; Dose-Response Relationship, Drug; Indoles; Injections, Spinal; Male; Molecular Sequence Data; Morphinans; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta

1992
Evidence that endogenous opioids mediate the antinociceptive effects of intrathecally administered calcium in mice.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 262, Issue:3

    Topics: Analgesia; Animals; Calcium; Drug Interactions; Endorphins; Indoles; Injections, Spinal; Male; Mice; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid

1992
Antagonist-induced transient down-regulation of delta-opioid receptors in NG108-15 cells.
    Molecular pharmacology, 1992, Volume: 42, Issue:3

    Topics: Amino Acid Sequence; Binding Sites; Binding, Competitive; Concanavalin A; Down-Regulation; Enkephalin, Leucine-2-Alanine; Glioma; Kinetics; Lysosomes; Molecular Sequence Data; Naloxone; Naltrexone; Narcotic Antagonists; Neuroblastoma; Receptors, Opioid; Receptors, Opioid, delta; Subcellular Fractions; Tritium; Tumor Cells, Cultured

1992
Effects of the delta-opioid receptor antagonist naltrindole on antinociceptive responses to selective delta-agonists in post-weanling rats.
    British journal of pharmacology, 1992, Volume: 107, Issue:2

    Topics: Analgesics; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Indoles; Male; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain Measurement; Rats; Rats, Wistar; Receptors, Opioid, delta

1992
Diprenorphine as a stimulus in drug discrimination learning.
    Pharmacology, biochemistry, and behavior, 1992, Volume: 43, Issue:3

    Topics: Animals; Chlorides; Conditioning, Psychological; Diprenorphine; Discrimination Learning; Dose-Response Relationship, Drug; Female; Generalization, Psychological; Lithium; Lithium Chloride; Morphine; Nalorphine; Naloxone; Naltrexone; Pentobarbital; Rats

1992
The pruritus of cholestasis and the opioid system.
    JAMA, 1992, Dec-16, Volume: 268, Issue:23

    Topics: Cholangitis, Sclerosing; Female; Humans; Middle Aged; Naloxone; Naltrexone; Narcotic Antagonists; Pruritus; Receptors, Opioid

1992
Opioid receptor antagonist affinity ligands: 6 beta-bromoacetamido-6-desoxynaltrexone and 6 beta-thioglycolamido-6-desoxynaltrexone.
    Neurochemical research, 1992, Volume: 17, Issue:12

    Topics: Affinity Labels; Analgesia; Animals; Brain; Cattle; Cell Membrane; Hydrogen-Ion Concentration; Kinetics; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Nicotine; Quinuclidinyl Benzilate; Receptors, Opioid

1992
The stimulation of central kappa opioid receptors decreases male sexual behavior and locomotor activity.
    Brain research, 1992, Oct-23, Volume: 594, Issue:1

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Behavior, Animal; Body Temperature; Injections; Male; Motor Activity; Naloxone; Naltrexone; Nucleus Accumbens; Preoptic Area; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, kappa; Sexual Behavior, Animal; Tegmentum Mesencephali

1992
On the mechanism of the interaction of ketamine and halothane in vitro.
    General pharmacology, 1992, Volume: 23, Issue:6

    Topics: Animals; Drug Interactions; GTP-Binding Proteins; Guinea Pigs; Halothane; Ileum; In Vitro Techniques; Ketamine; Muscle, Smooth; Muscle, Smooth, Vascular; Myenteric Plexus; Naloxone; Naltrexone; Pertussis Toxin; Receptors, Opioid; Virulence Factors, Bordetella

1992
Kappa-opioids decrease excitatory transmission in the dentate gyrus of the guinea pig hippocampus.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1992, Volume: 12, Issue:1

    Topics: Action Potentials; Animals; Benzeneacetamides; Diprenorphine; Dynorphins; Electrophysiology; Endorphins; Guinea Pigs; Hippocampus; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Synapses

1992
Naloxone and norbinaltorphimine administered intracerebroventricularly antagonize spinal morphine-induced antinociception in mice through the antianalgesic action of spinal dynorphin A (1-17).
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 261, Issue:1

    Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Dynorphins; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Naltrexone

1992
Activation of kappa-opioid receptors depresses electrically evoked excitatory postsynaptic potentials on 5-HT-sensitive neurones in the rat dorsal raphé nucleus in vitro.
    Brain research, 1992, Jun-26, Volume: 583, Issue:1-2

    Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Afferent Pathways; Animals; Benzofurans; Bicuculline; Bombesin; Cholecystokinin; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Evoked Potentials; Glutamates; Glutamic Acid; In Vitro Techniques; Kynurenic Acid; N-Methylaspartate; Naloxone; Naltrexone; Neurons; Picrotoxin; Prazosin; Pyrrolidines; Quinoxalines; Raphe Nuclei; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Serotonin; Synapses; Tetrodotoxin

1992
Tyr-MIF-1 and hemorphin can act as opiate agonists as well as antagonists in the guinea pig ileum.
    Life sciences, 1992, Volume: 51, Issue:11

    Topics: Amino Acid Sequence; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Hemoglobins; Ileum; In Vitro Techniques; Male; Molecular Sequence Data; Morphine; MSH Release-Inhibiting Hormone; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists; Peptide Fragments; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu

1992
Endogenous opioids may be involved in idazoxan-induced food intake.
    Neuropharmacology, 1992, Volume: 31, Issue:8

    Topics: Adrenergic alpha-Antagonists; Animals; Dioxanes; Dose-Response Relationship, Drug; Eating; Endorphins; Idazoxan; Indoles; Male; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains

1992
Effects of the opiates on the paraventricular nucleus in genetically polydipsic mice.
    Brain research, 1992, Dec-11, Volume: 598, Issue:1-2

    Topics: Animals; Dynorphins; Female; In Vitro Techniques; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Microinjections; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Neurons; Paraventricular Hypothalamic Nucleus; Quaternary Ammonium Compounds; Synapses; Thirst

1992
Identification of a novel receptor mediating substance P-induced behavior in the mouse.
    European journal of pharmacology, 1992, Jul-07, Volume: 217, Issue:2-3

    Topics: Analysis of Variance; Animals; Behavior, Animal; Binding Sites; Indoles; Injections, Spinal; Male; Mice; Morphinans; Naloxone; Naltrexone; Peptide Fragments; Substance P

1992
Opioid modulation of thermal dehydration-induced thirst in rats.
    Pharmacology, biochemistry, and behavior, 1992, Volume: 43, Issue:4

    Topics: Animals; Dehydration; Dose-Response Relationship, Drug; Hot Temperature; Injections, Intraperitoneal; Injections, Intraventricular; Male; Naloxone; Naltrexone; Rats; Rats, Sprague-Dawley; Thirst

1992
Repeated systemic administration of the mixed inhibitor of enkephalin-degrading enzymes, RB101, does not induce either antinociceptive tolerance or cross-tolerance with morphine.
    European journal of pharmacology, 1992, Nov-13, Volume: 223, Issue:1

    Topics: Analgesics; Animals; Disulfides; Dose-Response Relationship, Drug; Drug Tolerance; Indoles; Male; Mice; Morphinans; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Phenylalanine; Prodrugs; Reaction Time

1992
Analgesic and aversive effects of naloxone in BALB/c mice.
    Experimental neurology, 1992, Volume: 117, Issue:2

    Topics: Analgesia; Animals; Choice Behavior; Dose-Response Relationship, Drug; Formaldehyde; Mice; Mice, Inbred BALB C; Naloxone; Naltrexone; Pain

1992
Effects of beta-funaltrexamine on butorphanol dependence.
    Pharmacology, biochemistry, and behavior, 1992, Volume: 42, Issue:1

    Topics: Animals; Behavior, Animal; Body Temperature; Body Weight; Butorphanol; Dose-Response Relationship, Drug; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Reinforcement Schedule; Substance Withdrawal Syndrome; Substance-Related Disorders

1992
Naloxone as a stimulus in drug discrimination learning: generalization to other opiate antagonists.
    Pharmacology, biochemistry, and behavior, 1992, Volume: 41, Issue:1

    Topics: Animals; Cues; Diprenorphine; Discrimination Learning; Female; Generalization, Psychological; Nalorphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Saccharin

1992
Apparent pA2 value of naltrexone is not changed in rats following continuous exposure to morphine or naloxone.
    Life sciences, 1992, Volume: 50, Issue:19

    Topics: Analysis of Variance; Animals; Body Weight; Dose-Response Relationship, Drug; Drug Interactions; Fentanyl; Male; Morphine; Naloxone; Naltrexone; Pain Measurement; Rats; Rats, Inbred Strains

1992
Feedback inhibition of met-enkephalin release from the rat spinal cord in vivo.
    Synapse (New York, N.Y.), 1992, Volume: 11, Issue:1

    Topics: Animals; Calcitonin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Feedback; Indoles; Injections, Spinal; Leucine; Male; Morphinans; Naloxone; Naltrexone; Oligopeptides; Radioimmunoassay; Rats; Rats, Inbred Strains; Spinal Cord; Thiorphan

1992
(D-Ala2)deltorphin II: D1-dependent stereotypies and stimulation of dopamine release in the nucleus accumbens.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1991, Volume: 11, Issue:6

    Topics: Animals; Brain; Caudate Nucleus; Cerebral Ventricles; Dopamine; Endorphins; Functional Laterality; Indoles; Infusions, Parenteral; Injections, Intraventricular; Male; Morphinans; Motor Activity; Naloxone; Naltrexone; Nucleus Accumbens; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Stereotyped Behavior

1991
Differential effects of selective mu-, kappa- and delta-opioid antagonists on electroshock seizure threshold in mice.
    Psychopharmacology, 1991, Volume: 103, Issue:3

    Topics: Animals; Anticonvulsants; Bicuculline; Dose-Response Relationship, Drug; Electroshock; gamma-Aminobutyric Acid; Indoles; Male; Mice; Mice, Inbred Strains; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Phenytoin; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu

1991
Opioid delta agonists and endogenous enkephalins induce different emotional reactivity than mu agonists after injection in the rat ventral tegmental area.
    Psychopharmacology, 1991, Volume: 103, Issue:4

    Topics: Animals; Anxiety; Emotions; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Exploratory Behavior; Indoles; Injections; Male; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Tegmentum Mesencephali

1991
Endogenous opioids tonically inhibit the depressor neurones in the caudal ventrolateral medulla of rabbits: mediation through delta- and kappa-receptors.
    Neuropharmacology, 1991, Volume: 30, Issue:4

    Topics: Amino Acid Sequence; Animals; Endorphins; Enkephalin, Leucine; Hemodynamics; Male; Medulla Oblongata; Molecular Sequence Data; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Rabbits; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa

1991
Endogenous opioids regulate cell proliferation in the retina of developing rat.
    Brain research, 1991, Mar-22, Volume: 544, Issue:1

    Topics: Animals; Animals, Newborn; Autoradiography; Cell Division; DNA Replication; Endorphins; Enkephalin, Methionine; Female; Iodine Radioisotopes; Male; Mitotic Index; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Retina; Retinal Ganglion Cells; Thymidine

1991
Effects of parabrachial opioid antagonism on stimulation-induced feeding.
    Brain research, 1991, Apr-05, Volume: 545, Issue:1-2

    Topics: Animals; Electric Stimulation; Feeding Behavior; Hypothalamus; Infusions, Parenteral; Male; Microinjections; Naloxone; Naltrexone; Pons; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reference Values

1991
The opioid activity and receptor selectivity of fluorinated Leu5 enkephalin analogues in vitro and in vivo.
    Journal of pharmacobio-dynamics, 1991, Volume: 14, Issue:2

    Topics: Analgesics; Animals; Enkephalin, Leucine; Guinea Pigs; Ileum; In Vitro Techniques; Indoles; Male; Mice; Mice, Inbred Strains; Morphinans; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid

1991
Evaluation of receptor mechanism mediating fentanyl analgesia and toxicity.
    European journal of pharmacology, 1991, May-17, Volume: 197, Issue:2-3

    Topics: Analgesics; Animals; Brain; Drug Tolerance; Fentanyl; Lethal Dose 50; Male; Mice; Morphine; Naloxone; Naltrexone; Receptors, Opioid

1991
Opiate receptor antagonists for delusions of parasitosis.
    Biological psychiatry, 1991, Sep-01, Volume: 30, Issue:5

    Topics: Delusions; Female; Fentanyl; Fluspirilene; Humans; Middle Aged; Myiasis; Naloxone; Naltrexone; Narcotic Antagonists

1991
Opioid receptor activity of GI 87084B, a novel ultra-short acting analgesic, in isolated tissues.
    The Journal of pharmacology and experimental therapeutics, 1991, Volume: 259, Issue:2

    Topics: Alkylation; Animals; Enkephalin, Leucine; Guinea Pigs; Ileum; Kinetics; Male; Mice; Mice, Inbred Strains; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists; Piperidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Remifentanil; Vas Deferens

1991
In vitro effect of high doses of morphine on Con A induced lymphokine production.
    Advances in experimental medicine and biology, 1991, Volume: 288

    Topics: Animals; beta-Endorphin; Cell Survival; Cells, Cultured; Clone Cells; Colforsin; Concanavalin A; Cyclic AMP; Depression, Chemical; Dinoprostone; Dose-Response Relationship, Drug; Enkephalins; Female; Lymphocyte Activation; Lymphokines; Mice; Mice, Inbred C57BL; Morphine; Naloxone; Naltrexone; Protein Biosynthesis; Receptors, Opioid; Spleen; T-Lymphocytes, Helper-Inducer

1991
An enkephalinergic mechanism involved in amygdaloid suppression of affective defence behavior elicited from the midbrain periaqueductal gray in the cat.
    Brain research, 1991, Sep-13, Volume: 559, Issue:1

    Topics: Affect; Aggression; Amygdala; Animals; Cats; Electric Stimulation; Enkephalin, Leucine; Enkephalins; Female; Fluorescent Dyes; Homocysteine; Immunohistochemistry; Male; Naloxone; Naltrexone; Narcotic Antagonists; Periaqueductal Gray; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Stereotyped Behavior; Stilbamidines

1991
Behavioural effects of deltorphins in rats.
    European journal of pharmacology, 1991, Dec-17, Volume: 209, Issue:3

    Topics: Analgesics; Animals; Behavior, Animal; Indoles; Injections, Intraventricular; Male; Morphinans; Motor Activity; Naloxone; Naltrexone; Oligopeptides; Pain Measurement; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Social Behavior; Stereotyped Behavior

1991
Inhibition of suckling-induced prolactin release by mu- and kappa-opioid antagonists.
    Brain research, 1991, Dec-20, Volume: 567, Issue:2

    Topics: Animals; Depression, Chemical; Dose-Response Relationship, Drug; Female; Injections, Intraventricular; Lactation; Luteinizing Hormone; Naloxone; Naltrexone; Narcotic Antagonists; Prolactin; Rats; Rats, Inbred Strains; Receptors, Opioid, kappa; Receptors, Opioid, mu

1991
Spinal kappa receptor-mediated analgesia of E-2078, a systemically active dynorphin analog, in mice.
    The Journal of pharmacology and experimental therapeutics, 1991, Volume: 256, Issue:1

    Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Dynorphins; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Peptide Fragments; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord

1991
Hippocampal mu-receptors mediate opioid reinforcement in the CA3 region.
    Brain research, 1991, Apr-05, Volume: 545, Issue:1-2

    Topics: Animals; Dynorphins; Enkephalin, Leucine; Hippocampus; Kinetics; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pyramidal Tracts; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Reference Values; Reinforcement, Psychology; Self Administration

1991
U-50,488H inhibits dynorphin and glutamate release from guinea pig hippocampal mossy fiber terminals.
    Brain research, 1991, May-10, Volume: 548, Issue:1-2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Calcium; Dynorphins; Enkephalin, Leucine; Glutamates; Guinea Pigs; Hippocampus; Kinetics; Naloxone; Naltrexone; Narcotic Antagonists; Nerve Endings; Potassium Chloride; Pyrrolidines; Synaptosomes

1991
Intrathecal administration of dynorphin A and its fragments increase heart rate and arterial pressure in the urethane anesthetized rat: mediation by a nonopioid mechanism.
    Brain research, 1991, Nov-22, Volume: 565, Issue:1

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Anesthesia, General; Animals; Antihypertensive Agents; Blood Pressure; Diastole; Dynorphins; Heart Rate; Hexamethonium; Hexamethonium Compounds; Injections, Intravenous; Injections, Spinal; Male; Naloxone; Naltrexone; Peptide Fragments; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Reference Values; Systole

1991
Effect of opioid receptor antagonists on vasodilator nerve actions in the perfused rat mesentery.
    European journal of pharmacology, 1991, Nov-12, Volume: 204, Issue:3

    Topics: Animals; Calcitonin Gene-Related Peptide; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Guanethidine; In Vitro Techniques; Male; Mesenteric Arteries; Methoxamine; Muscle, Smooth, Vascular; Naloxone; Naltrexone; Narcotic Antagonists; Neurons, Afferent; Perfusion; Rats; Rats, Inbred Strains; Somatostatin; Vasodilation

1991
In vivo tonic inhibition of spinal substance P (-like material) release by endogenous opioid(s) acting at delta receptors.
    Neuroscience, 1991, Volume: 44, Issue:3

    Topics: Amino Acid Sequence; Animals; Depression, Chemical; Indoles; Injections, Spinal; Male; Molecular Sequence Data; Morphinans; Naloxone; Naltrexone; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Secretory Rate; Spinal Cord; Substance P

1991
Effects of naloxone and naltrexone on receptive and proceptive behaviors in female rats.
    Jikken dobutsu. Experimental animals, 1992, Volume: 41, Issue:1

    Topics: Animals; Female; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Sexual Behavior, Animal; Stimulation, Chemical

1992
Antagonism of acute cocaine toxicity by buprenorphine.
    Life sciences, 1991, Volume: 49, Issue:25

    Topics: Analysis of Variance; Animals; Buprenorphine; Cocaine; Dose-Response Relationship, Drug; L-Lactate Dehydrogenase; Male; Mice; Naloxone; Naltrexone

1991
Distribution and analgesia of [3H][D-Pen2, D-Pen5]enkephalin and two halogenated analogs after intravenous administration.
    The Journal of pharmacology and experimental therapeutics, 1991, Volume: 259, Issue:3

    Topics: Analgesics; Animals; Binding, Competitive; Drug Stability; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Indoles; Injections, Intravenous; Male; Mice; Mice, Inbred Strains; Morphinans; Naloxone; Naltrexone; Neprilysin; Tissue Distribution; Tritium

1991
Research note: naloxone inhibits drinking in the chick induced by angiotensin II.
    Poultry science, 1991, Volume: 70, Issue:9

    Topics: Angiotensin II; Animals; Chickens; Dose-Response Relationship, Drug; Drinking; Injections, Intramuscular; Injections, Subcutaneous; Male; Naloxone; Naltrexone

1991
Antinociceptive and gastrointestinal transit effects of cholecystokinin (CCK-8) and related analogs of CCK-8 in the mouse.
    Proceedings of the Western Pharmacology Society, 1991, Volume: 34

    Topics: Amino Acid Sequence; Analgesics; Animals; Benzodiazepinones; Cholecystokinin; Devazepide; Gastric Emptying; Gastrointestinal Transit; Indoles; Male; Mice; Mice, Inbred ICR; Molecular Sequence Data; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Peptide Fragments; Peptides; Phenylurea Compounds; Reaction Time; Receptors, Cholecystokinin; Sincalide

1991
Opiate antagonists inhibit feeding induced by 8-OH-DPAT: possible mediation in the nucleus accumbens.
    Brain research, 1991, Sep-27, Volume: 560, Issue:1-2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Eating; Injections, Subcutaneous; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Quaternary Ammonium Compounds; Raphe Nuclei; Rats; Rats, Inbred Strains; Tetrahydronaphthalenes

1991
Chronic selective blockade of mu opioid receptors produces analgesia and augmentation of the effects of a kappa agonist.
    Brain research, 1991, Jan-11, Volume: 538, Issue:2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics; Animals; Injections, Intraventricular; Injections, Subcutaneous; Male; Mice; Mice, Inbred Strains; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Pyrrolidines; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stereotaxic Techniques

1991
Comparison of naloxonazine and beta-funaltrexamine antagonism of mu 1 and mu 2 opioid actions.
    Life sciences, 1991, Volume: 48, Issue:21

    Topics: Animals; Drug Administration Schedule; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Subcutaneous; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, mu

1991
[Naloxone and naltrexone in the therapy of advanced COPD].
    Recenti progressi in medicina, 1991, Volume: 82, Issue:4

    Topics: Humans; Lung Diseases, Obstructive; Male; Middle Aged; Naloxone; Naltrexone; Pulmonary Emphysema; Tomography, X-Ray Computed

1991
Periaqueductal gray stimulation produces a spinally mediated, opioid antinociception for the inflamed hindpaw of the rat.
    Brain research, 1991, Apr-05, Volume: 545, Issue:1-2

    Topics: Analysis of Variance; Animals; Electric Stimulation; Freund's Adjuvant; Hindlimb; Inflammation; Male; Mycobacterium; Naloxone; Naltrexone; Pain; Periaqueductal Gray; Rats; Rats, Inbred Strains; Spinal Cord

1991
Endothelin-1-induced nociception.
    Life sciences, 1991, Volume: 49, Issue:11

    Topics: Animals; Endothelins; Male; Mice; Morphine; Naloxone; Naltrexone; Pain; Pain Measurement

1991
Opiate antagonists reduce cocaine but not nicotine self-administration.
    Psychopharmacology, 1991, Volume: 104, Issue:2

    Topics: Animals; Cocaine; Conditioning, Operant; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nicotine; Rats; Reinforcement Schedule; Self Administration

1991
Electroacupuncture in rats: evidence for naloxone and naltrexone potentiation of analgesia.
    Brain research, 1991, May-17, Volume: 549, Issue:1

    Topics: Aging; Analgesia; Analysis of Variance; Animals; China; Electroacupuncture; Female; Male; Naloxone; Naltrexone; Pain; Pain Management; Rats; Rats, Inbred Strains; Sensory Thresholds; Sex Characteristics; Species Specificity; United States

1991
Electroacupuncture analgesia in rats: naltrexone antagonism is dependent on previous exposure.
    Brain research, 1991, May-17, Volume: 549, Issue:1

    Topics: Analgesia; Analysis of Variance; Animals; China; Electroacupuncture; Male; Naloxone; Naltrexone; Pain; Pain Management; Rats; Rats, Inbred Strains; Species Specificity; Time Factors; United States

1991
Effect of morphine administration on rat liver metallothionein and zinc metabolism.
    The Journal of pharmacology and experimental therapeutics, 1991, Volume: 259, Issue:1

    Topics: Animals; Immobilization; Injections, Subcutaneous; Liver; Male; Metallothionein; Mifepristone; Morphine; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Zinc

1991
Role of opioid antagonists in the rat liver ischemia model.
    Transplantation proceedings, 1991, Volume: 23, Issue:5

    Topics: Animals; Calcium Channel Blockers; Hepatic Artery; Ischemia; Liver; Nalbuphine; Naloxone; Naltrexone; Narcotic Antagonists; Portal Vein; Rats; Rats, Inbred Strains; Verapamil

1991
Protective effect of nalmefene and naloxone on the ischemically damaged small bowel.
    Transplantation proceedings, 1991, Volume: 23, Issue:5

    Topics: Animals; Intestine, Small; Ischemia; Mesenteric Arteries; Naloxone; Naltrexone; Narcotic Antagonists; Necrosis; Rats; Rats, Inbred Strains; Time Factors

1991
Opioids and feeding reward.
    Appetite, 1991, Volume: 17, Issue:1

    Topics: Animals; Appetite Regulation; Endorphins; Feeding Behavior; Naloxone; Naltrexone; Rats; Reward

1991
The opioid receptor selectivity for trimebutine in isolated tissues experiments and receptor binding studies.
    Journal of pharmacobio-dynamics, 1990, Volume: 13, Issue:7

    Topics: Animals; Drug Tolerance; Guinea Pigs; Ileum; Male; Mice; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Rabbits; Receptors, Opioid; Trimebutine; Vas Deferens

1990
Electric muscle stimulation in the spontaneously hypertensive rat induces a post-stimulatory reduction in activity: role of different opioid receptors.
    Acta physiologica Scandinavica, 1990, Volume: 140, Issue:4

    Topics: Animals; Benzomorphans; Electric Stimulation; Hypertension; Male; Motor Activity; Muscles; Naloxone; Naltrexone; Rats; Rats, Inbred SHR; Receptors, Opioid

1990
Kappa opiate receptors inhibit release of oxytocin from the magnocellular system during dehydration.
    Neuroendocrinology, 1990, Volume: 51, Issue:4

    Topics: Animals; Benzomorphans; Dehydration; Dynorphins; Endorphins; Hypertonic Solutions; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Osmolar Concentration; Oxytocin; Peptide Fragments; Pituitary Gland, Posterior; Protein Precursors; Radioimmunoassay; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Vasopressins

1990
Reflex peristalsis in the guinea pig isolated ileum is endogenously controlled by kappa opioid receptors.
    Naunyn-Schmiedeberg's archives of pharmacology, 1990, Volume: 341, Issue:5

    Topics: Animals; Dose-Response Relationship, Drug; Enkephalin, Leucine; Gastrointestinal Motility; Guinea Pigs; Ileum; Male; Naloxone; Naltrexone; Narcotic Antagonists; Peristalsis; Receptors, Opioid; Receptors, Opioid, kappa; Reflex; Somatostatin

1990
Negative chronotropic but no antiarrhythmic effect of (+)- and (-)-naloxone in rats and guinea pigs.
    Cardiovascular research, 1991, Volume: 25, Issue:3

    Topics: Aconitine; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Depression, Chemical; Guinea Pigs; Heart Rate; Male; Naloxone; Naltrexone; Ouabain; Rats; Stereoisomerism

1991
Technique for greatly shortening the transition from methadone to naltrexone maintenance of patients addicted to opiates.
    The American journal of psychiatry, 1991, Volume: 148, Issue:7

    Topics: Adult; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Male; Methadone; Midazolam; Naloxone; Naltrexone; Opioid-Related Disorders; Substance Withdrawal Syndrome

1991
Using antagonists to assess neurochemical coding of a drug's ability to establish a conditioned place preference.
    Pharmacology, biochemistry, and behavior, 1990, Volume: 37, Issue:3

    Topics: Analgesics; Animals; Brain Chemistry; Conditioning, Operant; Flumazenil; Habituation, Psychophysiologic; Male; Morphine; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Scopolamine

1990
5-Methylated naloxone, naltrexone, oxymorphone, and their 14-O-methyl ethers.
    Progress in clinical and biological research, 1990, Volume: 328

    Topics: Animals; Ethers; In Vitro Techniques; Methylation; Naloxone; Naltrexone; Narcotic Antagonists; Oxymorphone; Quaternary Ammonium Compounds; Receptors, Opioid; Structure-Activity Relationship

1990
Physical dependence on morphine using the mu receptor deficient CXBK mouse.
    Progress in clinical and biological research, 1990, Volume: 328

    Topics: Animals; Mice; Mice, Inbred C57BL; Morphine Dependence; Naloxone; Naltrexone; Receptors, Opioid; Receptors, Opioid, mu; Species Specificity; Substance Withdrawal Syndrome

1990
Effects of chronic treatment with specific antagonists on analgesia and physical dependence on morphine in rats.
    Progress in clinical and biological research, 1990, Volume: 328

    Topics: Analgesics; Animals; Indoles; Male; Morphinans; Morphine Dependence; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Weight Loss

1990
Selective opioid receptor antagonist effects upon intake of a high-fat diet in rats.
    Brain research, 1990, Feb-05, Volume: 508, Issue:2

    Topics: Animals; Dietary Fats; Dose-Response Relationship, Drug; Feeding Behavior; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid

1990
Apparent affinity of opioid antagonists in morphine-treated rhesus monkeys discriminating between saline and naltrexone.
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 252, Issue:2

    Topics: Animals; Discrimination Learning; Dose-Response Relationship, Drug; Female; Indoles; Macaca mulatta; Morphinans; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, mu

1990
Peripheral opioid receptors mediating antinociception in inflammation. Activation by endogenous opioids and role of the pituitary-adrenal axis.
    Pain, 1990, Volume: 41, Issue:1

    Topics: Adrenalectomy; Analysis of Variance; Animals; Cold Temperature; Dose-Response Relationship, Drug; Endorphins; Foot; Hypophysectomy; Inflammation; Male; Naloxone; Naltrexone; Nociceptors; Pituitary-Adrenal System; Rats; Rats, Inbred Strains; Receptors, Opioid; Stress, Physiological; Swimming

1990
Opioid receptor-mediated inhibition of dopamine and acetylcholine release from slices of rat nucleus accumbens, olfactory tubercle and frontal cortex.
    European journal of pharmacology, 1990, Jun-08, Volume: 181, Issue:3

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetylcholine; Animals; Benzomorphans; Cerebral Cortex; Corpus Striatum; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ergolines; In Vitro Techniques; Male; Naloxone; Naltrexone; Nucleus Accumbens; Olfactory Bulb; Oxymetazoline; Pyrrolidines; Quinpirole; Rats; Rats, Inbred Strains; Receptors, Opioid; Septal Nuclei

1990
Involvement of spinal kappa opioid receptors in the antinociception produced by intrathecally administered corticotropin-releasing factor in mice.
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 254, Issue:2

    Topics: Animals; Corticotropin-Releasing Hormone; Drug Interactions; Injections, Spinal; Injections, Subcutaneous; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Receptors, Opioid; Receptors, Opioid, kappa

1990
Stereoselectivity and subtype of the opiate receptor involved in stress-induced hypertension.
    European journal of pharmacology, 1990, Jun-21, Volume: 182, Issue:1

    Topics: Animals; Blood Pressure; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Hypertension; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Social Isolation; Stereoisomerism; Stress, Psychological

1990
"Paradoxical" analgesia and aggravated morphine dependence induced by opioid antagonists.
    Life sciences, 1990, Volume: 47, Issue:6

    Topics: Animals; Body Weight; Indoles; Male; Morphinans; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome; Substance-Related Disorders

1990
Peripheral opioid receptors mediating antinociception in inflammation. Evidence for activation by enkephalin-like opioid peptides after cold water swim stress.
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 255, Issue:2

    Topics: Analgesia; Animals; Dioxolanes; Dipeptides; Enkephalins; Inflammation; Leucine; Male; Naloxone; Naltrexone; Neprilysin; Rats; Rats, Inbred Strains; Receptors, Opioid; Stress, Physiological; Swimming; Thiorphan

1990
Morphine promotes the growth of HIV-1 in human peripheral blood mononuclear cell cocultures.
    AIDS (London, England), 1990, Volume: 4, Issue:9

    Topics: Cells, Cultured; Gene Products, gag; HIV Core Protein p24; HIV-1; Humans; Leukocytes, Mononuclear; Lymphocyte Activation; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Viral Core Proteins

1990
Hepatobiliary effects of morphine are mediated in the brain.
    Hepatology (Baltimore, Md.), 1990, Volume: 12, Issue:6

    Topics: Animals; Biliary Tract; Brain; Female; Injections, Intraperitoneal; Injections, Intravenous; Injections, Intraventricular; Injections, Subcutaneous; Liver; Male; Mice; Morphine; Naloxone; Naltrexone; Receptors, Opioid; Sulfobromophthalein

1990
Role of opioid receptors in the long-lasting blood pressure depression after electric muscle stimulation in the hind leg of the rat.
    Acta physiologica Scandinavica, 1990, Volume: 140, Issue:2

    Topics: Animals; Benzomorphans; Blood Pressure; Electric Stimulation; Enkephalin, Leucine; Heart Rate; Hindlimb; Male; Naloxone; Naltrexone; Physical Conditioning, Animal; Rats; Rats, Inbred SHR; Receptors, Opioid; Regional Blood Flow

1990
Simultaneous development of opioid tolerance and opioid antagonist-induced receptor upregulation.
    Brain research, 1990, Oct-08, Volume: 529, Issue:1-2

    Topics: Analgesia; Animals; Brain; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Kinetics; Male; Mice; Morphine; Naloxone; Naltrexone; Pain; Receptors, Opioid; Reference Values; Up-Regulation

1990
[D-Pen2, D-Pen5]enkephalin, the standard delta opioid agonist, induces morphine-like behaviors in mice.
    Psychopharmacology, 1990, Volume: 102, Issue:3

    Topics: Analgesics; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Motor Activity; Muscle Tonus; Naloxone; Naltrexone; Narcotic Antagonists; Stereotyped Behavior

1990
Phenylephrine-induced antinociception: investigations of potential neural and endocrine bases.
    Brain research, 1990, Oct-01, Volume: 528, Issue:2

    Topics: Adrenal Glands; Analgesics; Animals; Arginine Vasopressin; Blood Pressure; Corticosterone; Dexamethasone; Endocrine Glands; Heart Rate; Male; Monitoring, Physiologic; Naloxone; Naltrexone; Neural Pathways; Phenylephrine; Rats; Rats, Inbred Strains; Spinal Cord; Vasopressins

1990
Antitussive effects of two specific kappa-opioid agonists, U-50,488H and U-62,066E, in rats.
    European journal of pharmacology, 1990, Oct-09, Volume: 187, Issue:2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Antitussive Agents; Cisterna Magna; Cough; Injections; Ketanserin; Male; Methysergide; Morphine; Naloxone; Naltrexone; Pyrrolidines; Rats; Rats, Inbred Strains; Reflex

1990
Drugs to decrease alcohol drinking.
    Annals of medicine, 1990, Volume: 22, Issue:5

    Topics: Alcohol Drinking; Alcoholism; Animals; Extinction, Psychological; Male; Naloxone; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Rats; Rats, Inbred Strains

1990
Opiate antagonists enhance the working memory of rats in the radial maze.
    Pharmacology, biochemistry, and behavior, 1990, Volume: 36, Issue:3

    Topics: Animals; Male; Memory; Memory, Short-Term; Naloxone; Naltrexone; Rats; Retention, Psychology

1990
Enhanced sensitivity to behavioral effects of naltrexone in rats.
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 252, Issue:1

    Topics: Animals; Conditioning, Psychological; Cyclazocine; Dose-Response Relationship, Drug; Ethylketocyclazocine; Male; Morphine; Naloxone; Naltrexone; Rats; Salivation

1990
Opioid agonists and antagonists. 6-Desoxy-6-substituted lactone, epoxide, and glycidate ester derivatives of naltrexone and oxymorphone.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:7

    Topics: Animals; Binding, Competitive; Brain; Chemical Phenomena; Chemistry; Circular Dichroism; Epoxy Compounds; Ethers, Cyclic; Hydromorphone; Lactones; Male; Naloxone; Naltrexone; Oxymorphone; Propionates; Rats; Rats, Inbred Strains; Receptors, Opioid; Structure-Activity Relationship

1985
10-Ketonaltrexone and 10-ketooxymorphone.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:7

    Topics: Animals; Biological Assay; Brain; Chemical Phenomena; Chemistry; Guinea Pigs; Hydromorphone; Ileum; Male; Mice; Naloxone; Naltrexone; Oxymorphone; Receptors, Opioid; Structure-Activity Relationship; Vas Deferens

1985
Irreversible opiate agonists and antagonists. II. Evidence against a bivalent mechanism of action for opiate azines and diacylhydrazones.
    The Journal of pharmacology and experimental therapeutics, 1985, Volume: 235, Issue:3

    Topics: Animals; Binding, Competitive; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hydromorphone; In Vitro Techniques; Male; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Oxymorphone; Rats; Rats, Inbred Strains; Receptors, Opioid; Structure-Activity Relationship

1985
Agonist-antagonist properties of fluorescent opioid probes in the guinea-pig myenteric plexus-longitudinal muscle preparation.
    Naunyn-Schmiedeberg's archives of pharmacology, 1985, Volume: 331, Issue:4

    Topics: Animals; Chemical Phenomena; Chemistry; Depression, Chemical; Fluorescent Dyes; Guinea Pigs; Hydromorphone; Ileum; In Vitro Techniques; Male; Naloxone; Naltrexone; Oxymorphone; Receptors, Opioid; Stereoisomerism; Stimulation, Chemical

1985
Action of naloxone on myenteric neurons removed from morphine-treated guinea pigs.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 247, Issue:3

    Topics: Acetylcholine; Action Potentials; Animals; Endorphins; Guinea Pigs; Ileum; In Vitro Techniques; Magnesium; Morphine; Muscle Contraction; Myenteric Plexus; Naloxone; Naltrexone; Substance P

1988
Simultaneous extraction and chromatographic analysis of morphine, dilaudid, naltrexone and naloxone in biological fluids by high-performance liquid chromatography with electrochemical detection.
    Journal of chromatography, 1989, Jun-30, Volume: 491, Issue:1

    Topics: Animals; Chromatography, High Pressure Liquid; Electrochemistry; Hydromorphone; Male; Morphine; Naloxone; Naltrexone; Rats

1989
Physiologic and plasma hormone correlates of survival in endotoxic dogs: effects of opiate antagonists.
    Critical care medicine, 1989, Volume: 17, Issue:1

    Topics: Adrenocorticotropic Hormone; Animals; beta-Endorphin; Blood Pressure; Cardiac Output; Dogs; Endotoxins; Epinephrine; Male; Naloxone; Naltrexone; Norepinephrine; Receptors, Opioid; Salmonella typhimurium; Shock, Septic

1989
Analgesia produced by normal doses of opioid antagonists alone and in combination with morphine.
    Pain, 1989, Volume: 36, Issue:1

    Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Female; Mice; Mice, Inbred BALB C; Morphine; Naloxone; Naltrexone; Pain Measurement; Receptors, Opioid

1989
[Effect of opiate receptor agonists and antagonists on maternal aggression in rats].
    Biulleten' eksperimental'noi biologii i meditsiny, 1989, Volume: 107, Issue:2

    Topics: Aggression; Animals; Depression, Chemical; Female; Lactation; Maternal Behavior; Naloxone; Naltrexone; Narcotic Antagonists; Pregnancy; Rats; Receptors, Opioid; Stimulation, Chemical

1989
Naloxone antagonism of corticotropin-releasing hormone stimulation of prolactin secretion in rhesus monkeys.
    The Journal of clinical endocrinology and metabolism, 1989, Volume: 68, Issue:6

    Topics: Animals; Corticotropin-Releasing Hormone; Dose-Response Relationship, Drug; Drug Synergism; Female; Macaca mulatta; Naloxone; Naltrexone; Narcotic Antagonists; Ovariectomy; Prolactin; Receptors, Opioid; Time Factors

1989
Modulation of appetitively and aversively motivated behavior by the kappa opioid antagonist MR2266.
    Behavioral neuroscience, 1989, Volume: 103, Issue:3

    Topics: Animals; Appetitive Behavior; Arousal; Avoidance Learning; Benzomorphans; Brain; Conditioning, Classical; Dose-Response Relationship, Drug; Drinking; Fear; Female; Injections, Intraventricular; Morphinans; Motivation; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu

1989
Effects of selective opioid-receptor blockade on the hypothalamo-pituitary-adrenocortical responses to surgical trauma in the rat.
    The Journal of endocrinology, 1989, Volume: 121, Issue:2

    Topics: Adrenocorticotropic Hormone; Animals; Benzomorphans; Corticosterone; Dose-Response Relationship, Drug; Enkephalin, Leucine; Hypothalamo-Hypophyseal System; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pituitary-Adrenal System; Rats; Rats, Inbred Strains; Receptors, Opioid; Stress, Physiological

1989
Effects of opiate antagonists and their quaternary analogues on nucleus accumbens self-stimulation.
    Behavioural brain research, 1989, Jun-01, Volume: 33, Issue:2

    Topics: Animals; Brain Mapping; Male; Motivation; Naloxone; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Oxymorphone; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Receptors, Opioid; Self Stimulation; Septal Nuclei

1989
Inhibition of vagal transmission by cardiac sympathetic nerve stimulation in the dog: possible involvement of opioid receptor.
    The Journal of pharmacology and experimental therapeutics, 1989, Volume: 250, Issue:3

    Topics: Blood Pressure; Electric Stimulation; Enkephalin, Leucine; Heart; Heart Rate; Methacholine Chloride; Methacholine Compounds; Naloxone; Naltrexone; Norepinephrine; Prazosin; Receptors, Opioid; Sympathetic Nervous System; Synaptic Transmission; Vagus Nerve; Yohimbine

1989
Pharmacological characterization of supersensitivity to naltrexone in squirrel monkeys.
    The Journal of pharmacology and experimental therapeutics, 1989, Volume: 250, Issue:3

    Topics: Animals; Azocines; Behavior, Animal; Benzomorphans; Diprenorphine; Drug Administration Schedule; Morphine; Naloxone; Naltrexone; Receptors, Opioid; Saimiri

1989
Effects of opioid receptor antagonists on morphine-induced stupor in rabbits.
    Activitas nervosa superior, 1989, Volume: 31, Issue:2

    Topics: Animals; Coma; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rabbits; Receptors, Opioid

1989
The therapeutic efficacy of opiate antagonists in hemorrhagic shock.
    Resuscitation, 1989, Volume: 18, Issue:2-3

    Topics: Animals; Dogs; Endorphins; Hemodynamics; Morphinans; Nalbuphine; Naloxone; Naltrexone; Shock, Hemorrhagic

1989
Effects of the selective kappa opioid antagonist, nor-binaltorphimine, on electrically-elicited feeding in the rat.
    Life sciences, 1989, Volume: 45, Issue:19

    Topics: Animals; Brain; Eating; Electric Stimulation; Hypothalamus; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pons; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa

1989
Modulation of mu-mediated antinociception by delta agonists: characterization with antagonists.
    European journal of pharmacology, 1989, Oct-04, Volume: 169, Issue:1

    Topics: Analgesics; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu

1989
Kappa opioid receptors of human placental villi modulate acetylcholine release.
    Life sciences, 1989, Volume: 45, Issue:25

    Topics: Acetylcholine; Chorionic Villi; Diltiazem; Female; Humans; In Vitro Techniques; Kinetics; Morphine; Naloxone; Naltrexone; Pregnancy; Receptors, Opioid; Receptors, Opioid, kappa

1989
Role of central opiate receptor subtypes in the circulatory responses of awake rabbits to graded caval occlusions.
    The Journal of physiology, 1989, Volume: 419

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Blood Circulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Hemodynamics; Hemorrhage; Naloxone; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rabbits; Receptors, Opioid; Vena Cava, Inferior

1989
Lack of mixed agonist-antagonist properties of [Gln8-Gly31]-beta h-EP-Gly-Gly-NH2 and [Arg9,19,24,28,29]-beta h-EP in the rat vas deferens neuroeffector junction: studies with naloxone, beta-funaltrexamine and ICI 174,864.
    The Journal of pharmacy and pharmacology, 1989, Volume: 41, Issue:2

    Topics: Animals; beta-Endorphin; Endorphins; Enkephalin, Leucine; In Vitro Techniques; Male; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists; Neuroeffector Junction; Rats; Rats, Inbred Strains; Vas Deferens

1989
Evidence that the aversive effects of opioid antagonists and kappa-agonists are centrally mediated.
    Psychopharmacology, 1989, Volume: 98, Issue:2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Brain; Conditioning, Operant; Enkephalin, Leucine; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Somatostatin

1989
Hypothermia elicited by some prodynorphin-derived peptides: opioid and non-opioid actions.
    Neuropeptides, 1989, Volume: 14, Issue:1

    Topics: Animals; Benzomorphans; Body Temperature; Dynorphins; Endorphins; Hypothermia; Kinetics; Male; Motor Activity; Naloxone; Naltrexone; Peptide Fragments; Rats; Rats, Inbred Strains; Receptors, Opioid

1989
Intracerebroventricular physostigmine-induced analgesia: enhancement by naloxone, beta-funaltrexamine and nor-binaltorphimine and antagonism by dynorphin A (1-17).
    The Journal of pharmacology and experimental therapeutics, 1989, Volume: 251, Issue:3

    Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Dynorphins; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Narcotic Antagonists; Physostigmine; Time Factors

1989
The narcotic antagonist naltrexone has a biphasic effect on the nicotinic acetylcholine receptor.
    FEBS letters, 1985, Mar-11, Volume: 182, Issue:1

    Topics: Acetylcholine; Animals; Electric Conductivity; Ion Channels; Naloxone; Naltrexone; Rats; Receptors, Cholinergic

1985
Chloroacryloyl amides and alpha-methylenelactones from naltrexone, oxymorphone and fentanyl.
    Neuropeptides, 1985, Volume: 5, Issue:4-6

    Topics: Acrylates; Animals; Binding Sites; Brain; Chemical Phenomena; Chemistry; Fentanyl; Hydromorphone; In Vitro Techniques; Membranes; Naloxone; Naltrexone; Oxymorphone; Rats; Stereoisomerism

1985
Simultaneous identification and quantification of several opiates and derivatives by capillary gas chromatography and nitrogen selective detection.
    Zeitschrift fur Rechtsmedizin. Journal of legal medicine, 1989, Volume: 103, Issue:1

    Topics: Chromatography, Gas; Humans; Nalorphine; Naloxone; Naltrexone; Narcotics; Opioid-Related Disorders

1989
The implication of opiates in the glucocorticoid-mediated inhibition of LH secretion in rats.
    The Journal of endocrinology, 1989, Volume: 122, Issue:2

    Topics: Animals; Corticosterone; Dexamethasone; Luteinizing Hormone; Male; Naloxone; Naltrexone; Narcotic Antagonists; Orchiectomy; Pituitary Hormone-Releasing Hormones; Rats; Rats, Inbred Strains; Stimulation, Chemical

1989
Comparison of the duration of action of nalmefene and naloxone on the hypothalamic-pituitary axis of the rhesus monkey.
    Neuroendocrinology, 1989, Volume: 49, Issue:3

    Topics: Animals; Female; Hypothalamo-Hypophyseal System; Luteinizing Hormone; Macaca mulatta; Naloxone; Naltrexone; Prolactin; Time Factors

1989
Effects of naloxone and naltrexone on memory consolidation in CD1 mice: involvement of GABAergic mechanisms.
    Pharmacology, biochemistry, and behavior, 1989, Volume: 32, Issue:2

    Topics: Animals; Avoidance Learning; Bicuculline; gamma-Aminobutyric Acid; Male; Memory; Mice; Mice, Inbred Strains; Muscimol; Naloxone; Naltrexone; Picrotoxin

1989
Opioids in the systemic hemodynamic and renal responses to stress in spontaneously hypertensive rats.
    Hypertension (Dallas, Tex. : 1979), 1989, Volume: 13, Issue:6 Pt 2

    Topics: Animals; Blood Pressure; Consciousness; Endorphins; Hemodynamics; Hypertension; Kidney; Male; Naloxone; Naltrexone; Narcotic Antagonists; Natriuresis; Quaternary Ammonium Compounds; Rats; Rats, Inbred SHR; Stress, Physiological

1989
Delayed suppression of serum luteinizing hormone after naloxone treatment in neonatal female rats.
    Life sciences, 1989, Volume: 44, Issue:26

    Topics: Animals; Animals, Newborn; Female; Luteinizing Hormone; Morphine; Naloxone; Naltrexone; Pain; Rats; Rats, Inbred Strains; Secretory Rate; Time Factors

1989
Opiate antagonist treatment reinstates estrous cycles in middle-aged persistent-estrous rats.
    Biology of reproduction, 1989, Volume: 40, Issue:4

    Topics: Aging; Animals; Endorphins; Estrus; Female; Luteinizing Hormone; Naloxone; Naltrexone; Rats

1989
Opiate antagonists and self-stimulation: extinction-like response patterns suggest selective reward deficit.
    Brain research, 1989, Jul-17, Volume: 492, Issue:1-2

    Topics: Animals; Endorphins; Male; Naloxone; Naltrexone; Nucleus Accumbens; Rats; Rats, Inbred Strains; Reinforcement, Psychology; Self Stimulation; Septal Nuclei

1989
Opioid modulation of feeding and drinking in fowls.
    British poultry science, 1989, Volume: 30, Issue:2

    Topics: Animals; Chickens; Drinking; Eating; Enkephalin, Methionine; Female; Injections, Intramuscular; Injections, Intravenous; Injections, Intraventricular; Naloxone; Naltrexone; Time Factors

1989
Comparison of high-dose opioid antagonist effects on ovine fetal cardiovascular function.
    Developmental pharmacology and therapeutics, 1989, Volume: 13, Issue:1

    Topics: Animals; Blood Pressure; Dose-Response Relationship, Drug; Fetus; Gestational Age; Heart Rate; Levallorphan; Naloxone; Naltrexone; Sheep

1989
Does the blockade of opioid receptors influence the development of ethanol dependence?
    Alcohol and alcoholism (Oxford, Oxfordshire), 1987, Volume: 22, Issue:2

    Topics: Alcoholism; Animals; Diprenorphine; Female; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Seizures; Substance Withdrawal Syndrome

1987
Effects of beta-funaltrexamine on radiolabeled opioid binding.
    European journal of pharmacology, 1987, Aug-11, Volume: 140, Issue:2

    Topics: Animals; Binding, Competitive; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; In Vitro Techniques; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu

1987
Covalent labeling of mu opioid binding site by [3H]beta-funaltrexamine.
    Molecular pharmacology, 1987, Volume: 32, Issue:3

    Topics: Animals; Cattle; Chemical Phenomena; Chemistry; Chromatography, Affinity; Corpus Striatum; Electrophoresis, Polyacrylamide Gel; Kinetics; Ligands; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Temperature; Time Factors

1987
Opiate receptors and the endorphin-mediated cardiovascular effects of clonidine in rats: evidence for hypertension-induced mu-subtype to delta-subtype changes.
    Proceedings of the National Academy of Sciences of the United States of America, 1987, Volume: 84, Issue:23

    Topics: Animals; Blood Pressure; Clonidine; Endorphins; Enkephalin, Leucine; Heart Rate; Hypertension; Male; Naloxone; Naltrexone; Rats; Rats, Inbred SHR; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu

1987
Chronic morphine upregulates a mu-opiate binding site labeled by [3H]cycloFOXY: a novel opiate antagonist suitable for positron emission tomography.
    European journal of pharmacology, 1987, Oct-06, Volume: 142, Issue:1

    Topics: Alkylating Agents; Animals; Binding, Competitive; Drug Tolerance; Enkephalin, Leucine; In Vitro Techniques; Male; Morphine; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Tomography, Emission-Computed

1987
Stereochemistry of novel delta selective opiate antagonists.
    NIDA research monograph, 1986, Volume: 75

    Topics: Estrone; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Naloxone; Naltrexone; Pregnenolone; Receptors, Opioid; Receptors, Opioid, delta; X-Ray Diffraction

1986
Opioid components of the clockwork that governs luteinizing hormone and prolactin release in male rats.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 1988, Volume: 2, Issue:13

    Topics: Animals; Circadian Rhythm; Dose-Response Relationship, Drug; Endorphins; Ligands; Luteinizing Hormone; Male; Naloxone; Naltrexone; Pituitary Gland, Anterior; Prolactin; Rats; Rats, Inbred Strains; Receptors, Opioid

1988
beta-FNA binds irreversibly to the opiate receptor complex: in vivo and in vitro evidence.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 247, Issue:2

    Topics: Animals; Binding Sites; Binding, Competitive; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Injections, Intraventricular; Male; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu

1988
Influence of neonatal opioid blockade or injections of gonadotrophin-releasing hormone on the timing of puberty in female rats: correlation of opioid effects with occupation of hypothalamic mu-opioid receptors.
    The Journal of endocrinology, 1988, Volume: 119, Issue:3

    Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Hypothalamus; Naloxone; Naltrexone; Pituitary Hormone-Releasing Hormones; Rats; Receptors, Opioid; Receptors, Opioid, mu; Sexual Maturation; Time Factors

1988
Emergence and development of stress-induced analgesia and concomitant behavioral changes in mice exposed to social conflict.
    Physiology & behavior, 1988, Volume: 44, Issue:3

    Topics: Aggression; Agonistic Behavior; Animals; Arousal; Brain; Conflict, Psychological; Escape Reaction; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Naloxone; Naltrexone; Nociceptors; Receptors, Opioid; Social Environment

1988
Lack of evidence for epsilon-opioid receptors in the rat vas deferens.
    European journal of pharmacology, 1988, Sep-23, Volume: 154, Issue:3

    Topics: Animals; Calcium; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; In Vitro Techniques; Male; Muscle Contraction; Naloxone; Naltrexone; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Vas Deferens

1988
Opposite effects of mu and kappa opiate agonists on dopamine release in the nucleus accumbens and in the dorsal caudate of freely moving rats.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 244, Issue:3

    Topics: Animals; Benzomorphans; Caudate Nucleus; Dopamine; Male; Methadone; Morphine; Motor Activity; Naloxone; Naltrexone; Nucleus Accumbens; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reward; Septal Nuclei

1988
Inhibition by opioid agonists and enhancement by antagonists of the release of catecholamines from the dog adrenal gland in response to splanchnic nerve stimulation: evidence for the functional role of opioid receptors.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 244, Issue:3

    Topics: Adrenal Glands; Animals; Catecholamines; Dogs; Electric Stimulation; Enkephalin, Leucine; Female; Male; Morphine; Naloxone; Naltrexone; Receptors, Opioid; Splanchnic Nerves

1988
Treatment of stroke with opiate antagonists--effects of exogenous antagonists and dynorphin 1-13.
    Neuropeptides, 1985, Volume: 5, Issue:4-6

    Topics: Acute Disease; Animals; Brain Ischemia; Cats; Dynorphins; Enkephalin, Leucine; Male; Naloxone; Naltrexone; Narcotic Antagonists; Peptide Fragments

1985
Simultaneous quantitation of norepinephrine, dopamine and serotonin in brain during and following chronic naltrexone administration.
    Brain research, 1985, Aug-05, Volume: 340, Issue:1

    Topics: Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Dopamine; Female; Naloxone; Naltrexone; Neurotransmitter Agents; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, Opioid; Serotonin; Time Factors

1985
An analysis of naltrexone and naloxone's possible agonistic actions in the dog.
    Drug and alcohol dependence, 1985, Volume: 15, Issue:4

    Topics: Analgesics, Opioid; Animals; Cyclazocine; Dogs; Drug Synergism; Electroencephalography; Ethylketocyclazocine; Evoked Potentials; Female; Fentanyl; Morphine; Naloxone; Naltrexone; Reaction Time; Reflex; Reflex, Pupillary

1985
Chronic desipramine attenuates morphine analgesia.
    Pharmacology, biochemistry, and behavior, 1986, Volume: 24, Issue:1

    Topics: Analgesics, Opioid; Animals; Desipramine; Drug Interactions; Male; Mice; Morphine; Naloxone; Naltrexone; Propranolol; Reaction Time

1986
Opiate antagonists do not alter neuronal responses to stimulation of opioid-containing pathways in rat hippocampus.
    Neuropeptides, 1986, Volume: 7, Issue:1

    Topics: Animals; Dynorphins; Endorphins; Evoked Potentials; Hippocampus; In Vitro Techniques; Naloxone; Naltrexone; Peptide Fragments; Rats; Synaptic Transmission

1986
[Frequency as the cardinal determinant for electroacupuncture analgesia to be reversed by opioid antagonists].
    Sheng li xue bao : [Acta physiologica Sinica], 1986, Volume: 38, Issue:5

    Topics: Acupuncture Therapy; Animals; beta-Endorphin; Dynorphins; Electric Stimulation Therapy; Endorphins; Enkephalins; Naloxone; Naltrexone; Pain; Rats; Sensory Thresholds; Transcutaneous Electric Nerve Stimulation

1986
Binaltorphimine and nor-binaltorphimine, potent and selective kappa-opioid receptor antagonists.
    Life sciences, 1987, Mar-30, Volume: 40, Issue:13

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Chemical Phenomena; Chemistry; Cyclazocine; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Male; Mice; Morphine; Naloxone; Naltrexone; Pyrrolidines; Rabbits; Receptors, Opioid; Receptors, Opioid, kappa

1987
An examination of the opiate receptor subtypes labeled by [3H]cycloFOXY: an opiate antagonist suitable for positron emission tomography.
    Biological psychiatry, 1988, Mar-01, Volume: 23, Issue:5

    Topics: Animals; Autoradiography; Brain; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Naloxone; Naltrexone; Peptide Fragments; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Synaptic Membranes; Tomography, Emission-Computed

1988
High doses of L-naloxone but neither D-naloxone nor beta-funaltrexamine prevent hyperthermia-induced seizures in rat pups.
    The Journal of pharmacy and pharmacology, 1988, Volume: 40, Issue:3

    Topics: Animals; Body Temperature; Hyperthermia, Induced; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Seizures; Stereoisomerism

1988
Endorphins in primate hemorrhagic shock: beneficial action of opiate antagonists.
    The Journal of surgical research, 1986, Volume: 40, Issue:3

    Topics: Animals; beta-Endorphin; Disease Models, Animal; Dose-Response Relationship, Drug; Endorphins; Female; Hemodynamics; Naloxone; Naltrexone; Narcotic Antagonists; Papio; Shock, Hemorrhagic; Time Factors

1986
Opioid-mediated cardiovascular effects of clonidine in spontaneously hypertensive rats: elimination by neonatal treatment with monosodium glutamate.
    Endocrinology, 1986, Volume: 118, Issue:5

    Topics: Animals; Animals, Newborn; Arcuate Nucleus of Hypothalamus; beta-Endorphin; Blood Pressure; Clonidine; Endorphins; Enkephalin, Leucine; Glutamates; Heart Rate; Hemodynamics; Hypertension; Medulla Oblongata; Naloxone; Naltrexone; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Sodium Glutamate

1986
Pro-opiomelanocortin-derived peptides in the testis: evidence for a possible role in Leydig and Sertoli cell function.
    Medical biology, 1986, Volume: 63, Issue:5-6

    Topics: Animals; beta-Endorphin; Castration; Cell Differentiation; Chromatography, High Pressure Liquid; Endorphins; Hypophysectomy; Leydig Cells; Male; Naloxone; Naltrexone; Pro-Opiomelanocortin; Progesterone; Rats; Rats, Inbred Strains; RNA, Messenger

1986
Antagonism by naltrexone of the hypotension and bradycardia induced by alpha-methyldopa in conscious normotensive rats.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 244, Issue:1

    Topics: Animals; beta-Endorphin; Bradycardia; Dose-Response Relationship, Drug; Heart Rate; Hypotension; Immune Sera; Male; Methyldopa; Naloxone; Naltrexone; Rats; Rats, Inbred Strains

1988
[Naloxone and naltrexone in the treatment of chronic obstructive bronchopneumopathies].
    Presse medicale (Paris, France : 1983), 1988, Oct-29, Volume: 17, Issue:38

    Topics: Humans; Lung Diseases, Obstructive; Male; Middle Aged; Naloxone; Naltrexone

1988
Possible delta receptor mediation of the effect of beta-endorphin on luteinizing hormone (LH) release, but not on prolactin (PRL) release, in the ovariectomized rat.
    Endocrinology, 1985, Volume: 116, Issue:1

    Topics: Animals; beta-Endorphin; Castration; Endorphins; Enkephalin, Leucine; Female; Kinetics; Luteinizing Hormone; Naloxone; Naltrexone; Narcotic Antagonists; Prolactin; Rats; Rats, Inbred Strains; Receptors, Opioid

1985
Neurochemical and functional correlates of naltrexone-induced opiate receptor up-regulation.
    The Journal of pharmacology and experimental therapeutics, 1985, Volume: 232, Issue:2

    Topics: Animals; Brain Chemistry; Guanosine Triphosphate; Male; Morphine; Naloxone; Naltrexone; Pain; Rats; Rats, Inbred Strains; Receptors, Opioid; Time Factors

1985
TENA, a selective kappa opioid receptor antagonist.
    Life sciences, 1985, Feb-25, Volume: 36, Issue:8

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Azocines; Benzomorphans; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Ileum; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vas Deferens

1985
Opioid receptor binding characteristics of the non-equilibrium mu antagonist, beta-funaltrexamine (beta-FNA).
    European journal of pharmacology, 1985, Jan-08, Volume: 107, Issue:3

    Topics: Animals; Brain; Enkephalin, Methionine; In Vitro Techniques; Ligands; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tritium

1985
Prolonged in vivo antagonism of central mu- and delta-opioid receptor activity by beta-funal trexamine.
    Life sciences, 1985, Apr-08, Volume: 36, Issue:14

    Topics: Animals; Female; Injections, Intraventricular; Injections, Spinal; Muscle Contraction; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Urinary Bladder

1985
Chronic naltrexone treatment increases the heroin-produced facilitation of self-stimulation.
    Pharmacology, biochemistry, and behavior, 1985, Volume: 22, Issue:2

    Topics: Animals; Drug Synergism; Heroin; Male; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Self Stimulation; Time Factors

1985
Effect of sodium chloride on opiate receptor binding in spontaneously hypertensive rats: dependence on age.
    Clinical and experimental hypertension. Part A, Theory and practice, 1985, Volume: 7, Issue:1

    Topics: Animals; Blood Pressure; Brain; Drug Implants; Female; Hypertension; Male; Naloxone; Naltrexone; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Opioid; Sodium Chloride

1985
Effects of opiates on urine output in the water-loaded rat and reversal by beta-funaltrexamine.
    Neuropeptides, 1985, Volume: 5, Issue:4-6

    Topics: Animals; Diuresis; Male; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu

1985
Multi-dimensional analyses of behavior in mice treated with naltrexone.
    Physiology & behavior, 1985, Volume: 34, Issue:2

    Topics: Animals; Brain; Male; Mice; Mice, Inbred Strains; Motor Activity; Naloxone; Naltrexone; Receptors, Opioid

1985
Effects of 5,5'-dithiobis-(2-nitrobenzoic acid) on opiate binding to both the membrane-bound receptor and the partially purified opiate receptor.
    Journal of neurochemistry, 1985, Volume: 45, Issue:2

    Topics: Animals; Butorphanol; Cell Membrane; Dihydromorphine; Diprenorphine; Dithionitrobenzoic Acid; Dithiothreitol; Etorphine; Morphine; Nalorphine; Naloxone; Naltrexone; Nitrobenzoates; Oxymorphone; Rats; Receptors, Opioid

1985
Plasma corticosterone changes in response to central or peripheral administration of kappa and sigma opiate agonists.
    The Journal of pharmacology and experimental therapeutics, 1985, Volume: 233, Issue:3

    Topics: Animals; Brain; Corticosterone; Cyclazocine; Ethylketocyclazocine; Humans; Hypothalamo-Hypophyseal System; Male; Morphine; Naloxone; Naltrexone; Opioid-Related Disorders; Phenazocine; Pituitary-Adrenal System; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, sigma

1985
Increased analgesic potency of morphine and increased brain opioid binding sites in the rat following chronic naltrexone treatment.
    Life sciences, 1985, Jun-17, Volume: 36, Issue:24

    Topics: Animals; Binding, Competitive; Brain; Drug Implants; Drug Interactions; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Morphine; Naloxone; Naltrexone; Pain; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Opioid; Time Factors

1985
Binding of a new opiate antagonist, nalmefene, to rat brain membranes.
    Methods and findings in experimental and clinical pharmacology, 1985, Volume: 7, Issue:4

    Topics: Animals; Binding, Competitive; Brain; In Vitro Techniques; Kinetics; Membranes; Naloxone; Naltrexone; Rats; Receptors, Opioid; Receptors, Opioid, mu

1985
The anticonvulsant effects of DADLE are primarily mediated by activation of delta opioid receptors: interactions between delta and mu receptor antagonists.
    Life sciences, 1985, Aug-12, Volume: 37, Issue:6

    Topics: Animals; Anticonvulsants; Cerebral Ventricles; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Seizures

1985
Castration affects male rat brain opiate receptor content.
    Neuroendocrinology, 1985, Volume: 41, Issue:1

    Topics: Animals; Brain; Castration; Filtration; Male; Naloxone; Naltrexone; Radioligand Assay; Rats; Receptors, Opioid

1985
Opiate antagonism reduces placentophagia and pup cleaning by parturient rats.
    Pharmacology, biochemistry, and behavior, 1985, Volume: 22, Issue:6

    Topics: Animals; Drug Tolerance; Feeding Behavior; Female; Labor, Obstetric; Maternal Behavior; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Placenta; Pregnancy; Rats; Rats, Inbred Strains; Receptors, Opioid; Time Factors

1985
Pre-incubation of guinea-pig myenteric plexus with beta-funaltrexamine: discrepancy between binding assays and bioassays.
    British journal of pharmacology, 1985, Volume: 85, Issue:3

    Topics: Animals; Binding, Competitive; Brain; Cricetinae; Guinea Pigs; In Vitro Techniques; Male; Mice; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Naloxone; Naltrexone; Narcotic Antagonists; Rabbits; Rats; Receptors, Opioid

1985
Radiosynthesis of [18F]3-acetylcyclofoxy: a high affinity opiate antagonist.
    The International journal of applied radiation and isotopes, 1985, Volume: 36, Issue:6

    Topics: Animals; Chromatography, High Pressure Liquid; Fluorine; Indicators and Reagents; Isotope Labeling; Kinetics; Naloxone; Naltrexone; Narcotic Antagonists; Radioisotopes; Receptors, Opioid

1985
Effect of mu and kappa opioid receptor agonists on rat plasma corticosterone levels.
    European journal of pharmacology, 1985, Oct-08, Volume: 116, Issue:1-2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Benzomorphans; Corticosterone; Dose-Response Relationship, Drug; Fentanyl; Male; Morphine; Naloxone; Naltrexone; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu

1985
Receptors for opioid peptides in the guinea-pig ileum.
    The Journal of pharmacology and experimental therapeutics, 1985, Volume: 235, Issue:2

    Topics: Alkylation; Animals; Dose-Response Relationship, Drug; Electric Stimulation; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Ileum; Male; Mice; Naloxone; Naltrexone; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Vas Deferens

1985
Analgesic effects of mu antagonists after naloxone non-reversible stress-induced analgesia.
    Brain research, 1985, Dec-16, Volume: 359, Issue:1-2

    Topics: Analgesics; Animals; Diprenorphine; Electroshock; Male; Nalorphine; Naloxone; Naltrexone; Pain; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Stress, Physiological

1985
Pharmacological evidence for a protective role of the endogenous opioid system on electroshock-induced seizures in the mouse.
    Neuroscience letters, 1985, Dec-04, Volume: 62, Issue:2

    Topics: Animals; Electroshock; Endorphins; Injections, Intraperitoneal; Male; Mice; Mice, Inbred C57BL; Morphine; Naloxone; Naltrexone; Receptors, Opioid; Seizures; Time Factors

1985
[3H]beta-funaltrexamine binds covalently to brain opioid receptors.
    European journal of pharmacology, 1985, Dec-17, Volume: 119, Issue:3

    Topics: Animals; Binding Sites; Cattle; Corpus Striatum; Guinea Pigs; Male; Naloxone; Naltrexone; Receptors, Opioid; Time Factors

1985
Effects of endogenous and exogenous opioids on splenic natural killer cell activity.
    Natural immunity and cell growth regulation, 1986, Volume: 5, Issue:1

    Topics: Adrenocorticotropic Hormone; Animals; beta-Endorphin; Cytotoxicity Tests, Immunologic; Electric Stimulation; Endorphins; Female; Injections, Intraperitoneal; Killer Cells, Natural; Male; Mice; Mice, Inbred Strains; Morphine; Naloxone; Naltrexone; Poly I-C; Spleen

1986
Activity of mu- and delta-selective opioid agonists in the guinea pig ileum preparation: differentiation into peptide and nonpeptide classes with beta-funaltrexamine.
    The Journal of pharmacology and experimental therapeutics, 1986, Volume: 238, Issue:2

    Topics: Animals; Endorphins; Guinea Pigs; Ileum; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Nalorphine; Naloxone; Naltrexone; Narcotics; Peptides; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship

1986
Central, stereoselective receptors mediate the acute effects of opiate antagonists on luteinizing hormone secretion.
    Life sciences, 1986, Oct-27, Volume: 39, Issue:17

    Topics: Animals; Brain; Injections, Intraventricular; Luteinizing Hormone; Male; Naloxone; Naltrexone; Quaternary Ammonium Compounds; Rats; Receptors, Opioid; Stereoisomerism

1986
Reversible and irreversible binding of beta-funaltrexamine to mu, delta and kappa opioid receptors in guinea pig brain membranes.
    The Journal of pharmacology and experimental therapeutics, 1986, Volume: 239, Issue:2

    Topics: Animals; Brain; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Ethylmaleimide; Guinea Pigs; Kinetics; Male; Membranes; Naloxone; Naltrexone; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sodium Chloride

1986
Evidence for coupling of the kappa opioid receptor to brain GTPase.
    Life sciences, 1986, Nov-10, Volume: 39, Issue:19

    Topics: Alkylation; Animals; Brain; Cell Membrane; Cerebellum; Endorphins; GTP Phosphohydrolases; Guinea Pigs; Macaca mulatta; Naloxone; Naltrexone; Phosphoric Monoester Hydrolases; Rats; Receptors, Opioid; Receptors, Opioid, kappa

1986
An analysis of naltrexone precipitated abstinence in morphine-dependent chronic spinal dogs.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 240, Issue:2

    Topics: Animals; Behavior, Animal; Cordotomy; Dogs; Dose-Response Relationship, Drug; Female; Morphine Dependence; Naloxone; Naltrexone; Receptors, Opioid; Substance Withdrawal Syndrome

1987
Evidence for mu opioid receptor mediation of enkephalin-induced electroencephalographic seizures.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 240, Issue:2

    Topics: Animals; Electroencephalography; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Naloxone; Naltrexone; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Seizures

1987
The pattern of [3H]cyclofoxy retention in rat brain after in vivo injection corresponds to the in vitro opiate receptor distribution.
    Brain research, 1987, Feb-03, Volume: 402, Issue:2

    Topics: Animals; Autoradiography; Brain; Cerebellum; Densitometry; Image Processing, Computer-Assisted; Injections; Male; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Tissue Distribution; Tritium

1987
Brain opioids and autism: an updated analysis of possible linkages.
    Journal of autism and developmental disorders, 1987, Volume: 17, Issue:2

    Topics: Autistic Disorder; Brain; Brain Damage, Chronic; Child; Emotions; Endorphins; Humans; Language Development Disorders; Naloxone; Naltrexone; Receptors, Opioid; Serotonin; Social Behavior

1987
Possible mediation of catecholaminergic pathways in the antinociceptive effect of an extract of Cannabis sativa L.
    Psychopharmacology, 1986, Volume: 89, Issue:2

    Topics: Analgesics; Animals; Benzomorphans; Cannabis; Dose-Response Relationship, Drug; Enkephalin, Leucine; Haplorhini; Hydroxydopamines; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Oxidopamine; Plant Extracts; Rats; Rats, Inbred Strains

1986
Naloxone and naltrexone. Application in COPD.
    Chest, 1988, Volume: 93, Issue:1

    Topics: Aged; Carbon Dioxide; Female; Humans; Lung Diseases, Obstructive; Male; Middle Aged; Naloxone; Naltrexone; Oxygen

1988
Role of endogenous opioids on ventilation and chemical control of breathing in pentobarbitone-anesthetized rats.
    Pharmacology, 1987, Volume: 35, Issue:6

    Topics: Anesthesia; Animals; Blood Gas Analysis; Carbon Dioxide; Endorphins; Hydrogen-Ion Concentration; Hypoxia; Injections, Intraventricular; Male; Naloxone; Naltrexone; Pentobarbital; Rats; Respiration; Respiratory Function Tests

1987
"Paradoxical" analgesia induced by naloxone and naltrexone.
    Psychopharmacology, 1988, Volume: 96, Issue:1

    Topics: Analgesics; Animals; Behavior, Animal; Delayed-Action Preparations; Injections, Subcutaneous; Male; Naloxone; Naltrexone; Rats; Rats, Inbred Strains

1988
Evaluation of the anti-arrhythmic potency of naltrexone in the isolated ischaemic rat heart.
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1988, Volume: 9, Issue:1

    Topics: Animals; Anti-Arrhythmia Agents; Coronary Disease; Female; In Vitro Techniques; Naloxone; Naltrexone; Rats; Rats, Inbred Strains

1988
Endogenous opioid systems and neural cancer: transmission and scanning electron microscopic studies of murine neuroblastoma in tissue culture.
    Brain research bulletin, 1988, Volume: 21, Issue:5

    Topics: Enkephalin, Methionine; Male; Microscopy, Electron, Scanning; Naloxone; Naltrexone; Neuroblastoma; Time Factors; Tumor Cells, Cultured

1988
Effects of opioid peptides on aldosterone production: stimulatory effect of leu-enkephalin.
    Endocrinology, 1988, Volume: 122, Issue:2

    Topics: Adrenal Cortex; Aldosterone; Animals; Cattle; Diprenorphine; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Naloxone; Naltrexone; Perfusion

1988
Evidence for the delivery of narcotic antagonists to the colon as their glucuronide conjugates.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 244, Issue:1

    Topics: Animals; Colon; Constipation; Diarrhea; Dose-Response Relationship, Drug; Glucuronates; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Skin Temperature; Substance-Related Disorders

1988
Opioidergic modulation of the oestradiol-induced LH surge in the rat: roles of ovarian steroids.
    The Journal of endocrinology, 1988, Volume: 116, Issue:1

    Topics: Animals; Diestrus; Estradiol; Female; Luteinizing Hormone; Naloxone; Naltrexone; Ovariectomy; Proestrus; Progesterone; Rats; Rats, Inbred Strains

1988
Acute supersensitivity to the discriminative stimulus effects of naltrexone in pigeons.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 244, Issue:2

    Topics: Animals; Binding Sites; Columbidae; Diprenorphine; Discrimination Learning; Dose-Response Relationship, Drug; Generalization, Stimulus; Morphine; Nalorphine; Naloxone; Naltrexone; Opioid-Related Disorders

1988
Effects of treatment with the opioid antagonists naloxone and naltrexone on LH secretion and on sexual maturation in immature female rats.
    The Journal of endocrinology, 1988, Volume: 117, Issue:2

    Topics: Animals; Animals, Newborn; Female; Luteinizing Hormone; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Sexual Maturation; Time Factors

1988
Comparative evaluation of different pathways for the liver toxicity of morphine using freshly isolated hepatocytes.
    Biochemical pharmacology, 1988, Jul-15, Volume: 37, Issue:14

    Topics: Animals; Glutathione; Liver; Male; Metyrapone; Morphine; Naloxone; Naltrexone; Rats; Rats, Inbred Strains

1988
Evidence for the involvement of central opioidergic systems in L-tyrosine methyl ester-induced analgesia in the rat.
    Pharmacology, 1988, Volume: 37, Issue:1

    Topics: Analgesia; Animals; Endorphins; Injections, Intraventricular; Injections, Subcutaneous; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Tyrosine

1988
Long-term analgesic reaction in attacked mice.
    Behavioral neuroscience, 1987, Volume: 101, Issue:6

    Topics: Aggression; Analgesia; Animals; Bites and Stings; Endorphins; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Naloxone; Naltrexone; Narcotic Antagonists

1987
Chronic antagonist infusion does not increase morphine antinociception in rat spinal cord.
    Brain research, 1987, Nov-10, Volume: 425, Issue:2

    Topics: Animals; Injections, Spinal; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Rats; Rats, Inbred Strains; Spinal Cord

1987
Effects of narcotic antagonists on self-injurious behavior: a single case study.
    Journal of the American Academy of Child and Adolescent Psychiatry, 1987, Volume: 26, Issue:6

    Topics: Adolescent; Humans; Male; Naloxone; Naltrexone; Self Mutilation

1987
Endogenous opioids and post-ictal increase in seizure threshold in Mongolian gerbils.
    Epilepsy research, 1987, Volume: 1, Issue:2

    Topics: Animals; Electric Stimulation; Endorphins; Gerbillinae; Morphine; Naloxone; Naltrexone; Pentylenetetrazole; Seizures

1987
Effect of endorphins on heart rate and blood pressure in adult dogs.
    The American journal of physiology, 1986, Volume: 250, Issue:5 Pt 2

    Topics: Animals; Atropine; Blood Pressure; Consciousness; Dogs; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Heart; Heart Rate; Naloxone; Naltrexone

1986
Opioid and non-opioid components of insulin-induced feeding.
    Pharmacology, biochemistry, and behavior, 1986, Volume: 24, Issue:4

    Topics: Animals; Blood Glucose; Brain; Drug Interactions; Endorphins; Feeding Behavior; Insulin; Male; Mice; Naloxone; Naltrexone

1986
Conditioned fear-induced opiate analgesia: a competing motivational state theory of stress analgesia.
    Annals of the New York Academy of Sciences, 1986, Volume: 467

    Topics: Analgesia; Animals; Avoidance Learning; Behavior, Animal; Conditioning, Classical; Endorphins; Fear; Formaldehyde; Models, Biological; Motor Activity; Naloxone; Naltrexone; Nociceptors; Sensory Thresholds; Shock; Stress, Physiological

1986
Effects of naloxone and naltrexone on meal patterns of freely-feeding rats.
    Pharmacology, biochemistry, and behavior, 1987, Volume: 26, Issue:3

    Topics: Animals; Circadian Rhythm; Feeding Behavior; Male; Naloxone; Naltrexone; Rats; Time Factors

1987
Evidence for opioid and non-opioid forms of stress-induced analgesia in the snail, Cepaea nemoralis.
    Brain research, 1987, Apr-28, Volume: 410, Issue:1

    Topics: Animals; Cold Temperature; Endorphins; Enkephalin, Leucine; Hot Temperature; Naloxone; Naltrexone; Pain; Reaction Time; Snails; Stress, Physiological

1987
[Effects of the opiate antagonists naloxone and naltrexone on the body temperature of rats].
    Eksperimentalna meditsina i morfologiia, 1987, Volume: 26, Issue:1

    Topics: Animals; Body Temperature; Dose-Response Relationship, Drug; Drug Interactions; Male; Morphine; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Time Factors

1987
Nitrous oxide-induced hypothermia in the rat.
    Life sciences, 1987, Aug-10, Volume: 41, Issue:6

    Topics: Animals; Body Temperature; Chloral Hydrate; Dose-Response Relationship, Drug; Drug Tolerance; Kinetics; Male; Morphine; Naloxone; Naltrexone; Nitrous Oxide; Rats

1987
The effects of opioid antagonists on ingestive behavior in the domestic fowl.
    Pharmacology, biochemistry, and behavior, 1987, Volume: 27, Issue:1

    Topics: Animals; Chickens; Drinking Behavior; Feeding Behavior; Naloxone; Naltrexone

1987
Immediate and long-term effects of opiate antagonists on postictal behaviour following amygdala kindling in the rat.
    European journal of pharmacology, 1987, Sep-23, Volume: 141, Issue:3

    Topics: Amygdala; Animals; Behavior, Animal; Electric Stimulation; Kindling, Neurologic; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Seizures

1987
Antagonism by nalmefene of systemic and intrathecal morphine-induced analgesia in mice.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1987, Volume: 186, Issue:2

    Topics: Analgesia; Animals; Injections, Intravenous; Injections, Spinal; Male; Mice; Morphine; Naloxone; Naltrexone; Time Factors

1987
Strain differences in reversal of conditional analgesia by opioid antagonists.
    Behavioral neuroscience, 1987, Volume: 101, Issue:5

    Topics: Analgesia; Animals; Conditioning, Psychological; Female; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Species Specificity

1987
Antagonism of endogenous opioids modulates memory processing.
    Brain research, 1987, Oct-06, Volume: 422, Issue:2

    Topics: Animals; Anisomycin; Avoidance Learning; Dose-Response Relationship, Drug; Electroshock; Endorphins; Learning; Male; Memory; Mice; Naloxone; Naltrexone; Scopolamine

1987
Hypotensive effect of naloxone on high blood pressure induced by stress in the rat.
    Life sciences, 1987, Nov-30, Volume: 41, Issue:22

    Topics: Acoustic Stimulation; Animals; Blood Pressure; Cold Temperature; Electroshock; Hypertension; Male; Naloxone; Naltrexone; Photic Stimulation; Rats; Rats, Inbred Strains; Social Isolation; Stress, Physiological; Stress, Psychological

1987
The effects of opioid receptor antagonists suggest that testicular opiates regulate Sertoli and Leydig cell function in the neonatal rat.
    Endocrinology, 1986, Volume: 118, Issue:5

    Topics: Androgen-Binding Protein; Animals; Animals, Newborn; Dose-Response Relationship, Drug; Endorphins; Hypertrophy; Leydig Cells; Male; Naloxone; Naltrexone; Orchiectomy; Rats; Rats, Inbred Strains; Sertoli Cells; Testis; Testosterone

1986
Evidence for a central but not adrenal, opioid mediation in hypertension induced by brief isolation in the rat.
    Life sciences, 1986, May-26, Volume: 38, Issue:21

    Topics: Adrenalectomy; Animals; Blood Pressure; Corticosterone; Endorphins; Gastrointestinal Motility; Male; Morphine; Nalorphine; Naloxone; Naltrexone; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Social Isolation; Stress, Physiological

1986
Endogenous analgesia in the pregnant rat: an artifact of weight-dependent measures?
    Brain research, 1986, May-14, Volume: 373, Issue:1-2

    Topics: Animals; Body Weight; Endorphins; Female; Naloxone; Naltrexone; Pain; Postpartum Period; Pregnancy; Pregnancy, Animal; Rats; Rats, Inbred Strains; Sensory Thresholds

1986
Comparison of the effects of morphine and immobilization stress on discrimination performance of rats.
    Behavioral neuroscience, 1986, Volume: 100, Issue:4

    Topics: Animals; Arousal; Attention; Conditioning, Operant; Discrimination, Psychological; Electroshock; Male; Morphine; Naloxone; Naltrexone; Orientation; Psychomotor Performance; Rats; Rats, Inbred Strains; Restraint, Physical; Stress, Psychological

1986
Effect of naloxone and naltrexone on the development of satiation measured in the runway: comparisons with d-amphetamine and d-fenfluramine.
    Pharmacology, biochemistry, and behavior, 1986, Volume: 25, Issue:1

    Topics: Animals; Dextroamphetamine; Endorphins; Feeding Behavior; Fenfluramine; Male; Naloxone; Naltrexone; Rats; Reaction Time; Satiation

1986
Low-level microwave irradiations affect central cholinergic activity in the rat.
    Journal of neurochemistry, 1987, Volume: 48, Issue:1

    Topics: Animals; Brain; Choline; Frontal Lobe; Hippocampus; Male; Microwaves; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Sodium

1987
Naloxone, naltrexone and body temperature.
    Life sciences, 1987, Mar-16, Volume: 40, Issue:11

    Topics: Animals; Body Temperature; Dose-Response Relationship, Drug; Kinetics; Male; Naloxone; Naltrexone; Rats; Rats, Inbred Strains

1987
Investigation into the use of narcotic antagonists in the treatment of a stereotypic behavior pattern (crib-biting) in the horse.
    American journal of veterinary research, 1987, Volume: 48, Issue:2

    Topics: Animals; Behavior, Animal; Female; Horses; Male; Naloxone; Naltrexone; Narcotic Antagonists

1987
[Naloxone and naltrexone antagonism of various central effects of morphine].
    Bollettino della Societa italiana di biologia sperimentale, 1986, Oct-30, Volume: 62, Issue:10

    Topics: Animals; Behavior, Animal; Central Nervous System; Female; Male; Mice; Morphine; Naloxone; Naltrexone; Pain Measurement; Rats; Substance Withdrawal Syndrome

1986
[Activity of naloxone and naltrexone on the development of the morphine withdrawal syndrome].
    Bollettino della Societa italiana di biologia sperimentale, 1986, Oct-30, Volume: 62, Issue:10

    Topics: Animals; Behavior, Animal; Female; Male; Mice; Morphine Dependence; Naloxone; Naltrexone; Rats; Substance Withdrawal Syndrome

1986
Unexpected effects of nalmefene, a new opiate antagonist, on the hypothalamic-pituitary-gonadal axis in the male rat.
    Steroids, 1985, Volume: 46, Issue:6

    Topics: Animals; Dose-Response Relationship, Drug; Feedback; Hypothalamo-Hypophyseal System; Luteinizing Hormone; Male; Naloxone; Naltrexone; Rats; Testosterone; Time Factors

1985
Exposure to a cat produces opioid analgesia in rats.
    Behavioral neuroscience, 1985, Volume: 99, Issue:4

    Topics: Animals; Endorphins; Fear; Female; Naloxone; Naltrexone; Nervous System; Pain; Rats; Rats, Inbred Strains; Reaction Time

1985
Historical introduction and review of chemistry.
    Drug and alcohol dependence, 1985, Volume: 14, Issue:3-4

    Topics: Analgesics; Chemistry; History, 20th Century; Nalorphine; Naloxone; Naltrexone; Narcotic Antagonists; Phenazocine

1985
Antinociceptive models displaying peripheral opioid activity.
    International journal of tissue reactions, 1985, Volume: 7, Issue:1

    Topics: Analgesics; Animals; Carrageenan; Codeine; Dextropropoxyphene; Dose-Response Relationship, Drug; Epoprostenol; Female; Indomethacin; Mice; Morphine; Movement; Nalorphine; Naloxone; Naltrexone; Narcotic Antagonists

1985
Blockade by naloxone and naltrexone of the TRH-induced stimulation of colonic transit in the rabbit.
    European journal of pharmacology, 1985, Feb-05, Volume: 108, Issue:3

    Topics: Animals; Colon; Gastrointestinal Motility; Injections, Intraventricular; Male; Naloxone; Naltrexone; Rabbits; Serotonin; Thyrotropin-Releasing Hormone

1985
Effects of morphine, naltrexone, and dextrorphan in untreated and morphine-treated pigeons.
    Psychopharmacology, 1985, Volume: 85, Issue:3

    Topics: Animals; Behavior, Animal; Body Weight; Columbidae; Conditioning, Operant; Dextrorphan; Dose-Response Relationship, Drug; Drug Tolerance; Morphinans; Morphine; Naloxone; Naltrexone; Stereoisomerism

1985
Treatment of experimental stroke with opiate antagonists. Effects on neurological function, infarct size, and survival.
    Journal of neurosurgery, 1986, Volume: 64, Issue:1

    Topics: Animals; Brain Ischemia; Cats; Cerebrovascular Disorders; Consciousness; Diprenorphine; Disease Models, Animal; Male; Morphinans; Movement; Naloxone; Naltrexone; Pupil; Sensation

1986
Independent central and peripheral mediation of morphine-induced inhibition of gastrointestinal transit in rats.
    The Journal of pharmacology and experimental therapeutics, 1986, Volume: 236, Issue:1

    Topics: Analgesia; Animals; Brain; Gastrointestinal Motility; Injections, Intraventricular; Injections, Subcutaneous; Male; Morphine; Naloxone; Naltrexone; Peripheral Nerves; Rats; Rats, Inbred Strains

1986
Naltrexone for opioid addiction.
    The Medical letter on drugs and therapeutics, 1985, Feb-01, Volume: 27, Issue:680

    Topics: Drug Interactions; Humans; Kinetics; Naloxone; Naltrexone; Opioid-Related Disorders; Socioeconomic Factors

1985
Naltrexone facilitation of sexual receptivity in the rat.
    Hormones and behavior, 1985, Volume: 19, Issue:1

    Topics: Adrenalectomy; Animals; Anisomycin; Castration; Drug Interactions; Endorphins; Female; Naloxone; Naltrexone; Pargyline; Posture; Rats; Sexual Behavior, Animal

1985
Pharmacokinetics of morphine and its surrogates V: Naltrexone and naltrexone conjugate pharmacokinetics in the dog as a function of dose.
    Journal of pharmaceutical sciences, 1985, Volume: 74, Issue:1

    Topics: Animals; Bile; Body Fluids; Chromatography, High Pressure Liquid; Dogs; Kidney; Kinetics; Liver; Morphine; Naloxone; Naltrexone

1985
Antagonism of brain opioid peptide action reduces hibernation bout duration.
    Brain research, 1985, Mar-04, Volume: 328, Issue:2

    Topics: Animals; Endorphins; Hibernation; Injections, Intraventricular; Injections, Subcutaneous; Naloxone; Naltrexone; Sciuridae

1985
Naltrexone fails to suppress spontaneous locomotor activity in hamsters.
    Pharmacology, biochemistry, and behavior, 1985, Volume: 22, Issue:3

    Topics: Animals; Cricetinae; Environment; Exploratory Behavior; Male; Mesocricetus; Mice; Motor Activity; Naloxone; Naltrexone; Rats; Species Specificity; Time Factors

1985
Naltrexone's influence on neurobehavioral development.
    Pharmacology, biochemistry, and behavior, 1985, Volume: 22, Issue:3

    Topics: Animals; Behavior, Animal; Body Weight; Female; Male; Motor Activity; Naloxone; Naltrexone; Nervous System; Nociceptors; Psychomotor Performance; Rats; Rats, Inbred Strains; Reflex; Time Factors; Weaning

1985
Hot-plate learning in mice is unaltered by immediate post-training administration of naloxone, naltrexone or morphine.
    Neuropharmacology, 1985, Volume: 24, Issue:4

    Topics: Animals; Endorphins; Hot Temperature; Learning; Male; Memory; Mice; Morphine; Naloxone; Naltrexone; Pain

1985
Opioid antagonist-induced regulation of organ development.
    Physiology & behavior, 1985, Volume: 34, Issue:4

    Topics: Animals; Animals, Suckling; Female; Growth; Male; Naloxone; Naltrexone; Organ Size; Organ Specificity; Rats; Rats, Inbred Strains; Sex Factors

1985
Effects of opioids and phencyclidine in combination with naltrexone on the acquisition and performance of response sequences in monkeys.
    Pharmacology, biochemistry, and behavior, 1985, Volume: 22, Issue:6

    Topics: Animals; Cyclazocine; Dose-Response Relationship, Drug; Erythrocebus patas; Female; Heroin; Methadone; Naloxone; Naltrexone; Narcotics; Phencyclidine; Reinforcement Schedule; Serial Learning

1985
Endogenous opiates participate in the regulation of pulsatile luteinizing hormone release in an unopposed estrogen milieu: studies in estrogen-replaced, gonadectomized patients with testicular feminization.
    The Journal of clinical endocrinology and metabolism, 1985, Volume: 61, Issue:4

    Topics: Adolescent; Adult; Androgen-Insensitivity Syndrome; Castration; Endorphins; Estradiol; Estrogens; Female; Humans; Luteinizing Hormone; Naloxone; Naltrexone

1985
Narcotic antagonist-induced hypotension in the spontaneously hypertensive rat.
    Life sciences, 1985, Sep-02, Volume: 37, Issue:9

    Topics: Animals; Blood Pressure; Dose-Response Relationship, Drug; Heart Rate; Hypertension; Male; Naloxone; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Stereoisomerism

1985
Discriminative stimulus effects of morphine withdrawal in the dependent rat: suppression by opiate and nonopiate drugs.
    The Journal of pharmacology and experimental therapeutics, 1985, Volume: 233, Issue:1

    Topics: Animals; Body Weight; Clonidine; Haloperidol; Humans; Male; Morphine Dependence; Naloxone; Naltrexone; Narcotics; Rats; Rats, Inbred Strains; Stereoisomerism; Substance Withdrawal Syndrome

1985
Hyperthermia in the rat from handling stress blocked by naltrexone injected into the preoptic-anterior hypothalamus.
    Pharmacology, biochemistry, and behavior, 1985, Volume: 22, Issue:2

    Topics: Animals; Body Temperature; Brain; Handling, Psychological; Humans; Hypothalamic Area, Lateral; Hypothalamus, Anterior; Injections; Injections, Intraperitoneal; Male; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Stress, Psychological

1985
Effects of naloxone and other opiate antagonists on blood-ethanol concentration in acutely-ethanol-intoxicated rats.
    Neuropeptides, 1985, Volume: 5, Issue:4-6

    Topics: Alcoholic Intoxication; Animals; Benzomorphans; Ethanol; Humans; Male; Morphinans; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Time Factors

1985
Naltrexone antagonizes the biobehavioral adaptation to cold water stress in rats.
    Pharmacology, biochemistry, and behavior, 1985, Volume: 22, Issue:5

    Topics: Adaptation, Physiological; Animals; Body Temperature; Central Nervous System; Cold Temperature; Endorphins; Male; Naloxone; Naltrexone; Neuronal Plasticity; Pain; Rats; Rats, Inbred Strains; Reaction Time; Stress, Physiological

1985
Narcotic antagonist potentiation of apomorphine drug effect: a stereospecific, centrally mediated drug action.
    Progress in neuro-psychopharmacology & biological psychiatry, 1985, Volume: 9, Issue:3

    Topics: Animals; Apomorphine; Drug Synergism; Exploratory Behavior; Humans; Male; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Narcotic Antagonists; Stereoisomerism; Stereotyped Behavior

1985
Cross-tolerance between morphine- and bombesin-induced inhibition of intestinal transit in rats.
    European journal of pharmacology, 1985, Aug-15, Volume: 114, Issue:2

    Topics: Animals; Bombesin; Drug Tolerance; Gastrointestinal Motility; Male; Morphine; Naloxone; Naltrexone; Rats; Rats, Inbred Strains

1985
Effects of buprenorphine on shock titration in squirrel monkeys.
    The Journal of pharmacology and experimental therapeutics, 1985, Volume: 235, Issue:1

    Topics: Animals; Buprenorphine; Conditioning, Operant; Diprenorphine; Dose-Response Relationship, Drug; Drug Interactions; Electroshock; Male; Morphinans; Morphine; Naloxone; Naltrexone; Saimiri

1985
Effects of beta-funaltrexamine in normal and morphine-dependent rhesus monkeys: observational studies.
    The Journal of pharmacology and experimental therapeutics, 1985, Volume: 235, Issue:2

    Topics: Animals; Azocines; Behavior, Animal; Dose-Response Relationship, Drug; Injections, Intraventricular; Injections, Subcutaneous; Macaca mulatta; Morphine; Muscle Relaxation; Naloxone; Naltrexone; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors

1985
Antagonistic and rate-suppressing effects of opioid antagonists in the pigeon.
    The Journal of pharmacology and experimental therapeutics, 1985, Volume: 235, Issue:2

    Topics: Animals; Azocines; Benzomorphans; Buprenorphine; Columbidae; Conditioning, Operant; Diprenorphine; Dose-Response Relationship, Drug; Morphine; Naloxone; Naltrexone; Narcotic Antagonists

1985
Asymmetric behavior induced by enkephalinergic agents in the basal ganglia.
    Pharmacology, biochemistry, and behavior, 1985, Volume: 23, Issue:2

    Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Ganglia, Spinal; Male; Naloxone; Naltrexone; Rats; Rats, Inbred Strains

1985
Intracerebroventricular drug administration in pigeons.
    Pharmacology, biochemistry, and behavior, 1985, Volume: 23, Issue:5

    Topics: Animals; Columbidae; Conditioning, Operant; Dose-Response Relationship, Drug; Injections, Intramuscular; Injections, Intraventricular; Morphine; Naloxone; Naltrexone; Pharmaceutical Preparations

1985
Effects of opioid antagonists and their quaternary derivatives on locomotor activity and fixed ratio responding for brain self-stimulation in rats.
    Pharmacology, biochemistry, and behavior, 1985, Volume: 23, Issue:5

    Topics: Animals; Brain Mapping; Conditioning, Operant; Male; Mesencephalon; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Reinforcement Schedule; Self Stimulation

1985
Effects of opiate antagonists on spatial memory in young and aged rats.
    Behavioral and neural biology, 1985, Volume: 44, Issue:3

    Topics: Age Factors; Aging; Animals; Diprenorphine; Male; Memory; Naloxone; Naltrexone; Rats; Space Perception; Stimulation, Chemical

1985
Effects of opiate antagonists on feeding and spontaneous locomotion in deer.
    Physiology & behavior, 1985, Volume: 35, Issue:6

    Topics: Animals; Brain; Deer; Endorphins; Feeding Behavior; Female; Male; Motor Activity; Naloxone; Naltrexone; Seasons

1985
Clinical use of naltrexone (EN-1639A): Part I: Safety and efficacy in pilot studies.
    The American journal of drug and alcohol abuse, 1974, Volume: 1, Issue:2

    Topics: Adult; Ambulatory Care; Drug Evaluation; Female; Heroin Dependence; Humans; Legislation, Drug; Male; Middle Aged; Naloxone; Naltrexone; Nausea; New York City; Pilot Projects; Sleep Initiation and Maintenance Disorders; Substance Withdrawal Syndrome; United States

1974
Stereospecificity of 4,5-epoxymorphinan binding to the lambda site in rat brain.
    European journal of pharmacology, 1984, May-18, Volume: 101, Issue:1-2

    Topics: Animals; Binding, Competitive; Brain; In Vitro Techniques; Male; Morphinans; Morphine; Naloxone; Naltrexone; Narcotics; Oxymorphone; Rats; Rats, Inbred Strains; Receptors, Opioid; Stereoisomerism

1984
Duration of opiate receptor blockade determines tumorigenic response in mice with neuroblastoma: a role for endogenous opioid systems in cancer.
    Life sciences, 1984, Jul-23, Volume: 35, Issue:4

    Topics: Analgesia; Animals; Cell Line; Male; Mice; Mice, Inbred Strains; Morphine; Naloxone; Naltrexone; Neuroblastoma; Receptors, Opioid

1984
Naltrexone in addicted business executives and physicians.
    The Journal of clinical psychiatry, 1984, Volume: 45, Issue:9 Pt 2

    Topics: Administrative Personnel; Adult; Aftercare; Ambulatory Care; Clonidine; Commerce; Female; Hospitalization; Humans; Male; Naloxone; Naltrexone; Opioid-Related Disorders; Patient Compliance; Physician Impairment

1984
Effect of beta-FNA on opiate delta receptor binding.
    Journal of neurochemistry, 1984, Volume: 43, Issue:4

    Topics: Animals; Brain; Cell Membrane; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Naloxone; Naltrexone; Oligopeptides; Protein Conformation; Rats; Receptors, Opioid

1984
Design and synthesis of naltrexone-derived affinity labels with nonequilibrium opioid agonist and antagonist activities. Evidence for the existence of different mu receptor subtypes in different tissues.
    Journal of medicinal chemistry, 1984, Volume: 27, Issue:10

    Topics: Affinity Labels; Animals; Chemical Phenomena; Chemistry; Guinea Pigs; Ileum; Indicators and Reagents; Kinetics; Magnetic Resonance Spectroscopy; Male; Mice; Morphine; Muscle, Smooth; Naloxone; Naltrexone; Receptors, Opioid; Receptors, Opioid, mu; Structure-Activity Relationship; Vas Deferens

1984
Enhancement of opiate-induced depressions in serum luteinizing hormone levels by the prior administration of naloxone in the male rat.
    Life sciences, 1984, Sep-17, Volume: 35, Issue:12

    Topics: Animals; Binding, Competitive; Brain; Dose-Response Relationship, Drug; Gonadotropin-Releasing Hormone; Kinetics; Luteinizing Hormone; Male; Morphine; Naloxone; Naltrexone; Narcotics; Rats; Rats, Inbred Strains; Receptors, Opioid

1984
Antagonism of diazepam-induced feeding in rats by antisera to opioid peptides.
    Life sciences, 1984, Sep-24, Volume: 35, Issue:13

    Topics: Animals; beta-Endorphin; Dexamethasone; Diazepam; Endorphins; Enkephalin, Methionine; Feeding Behavior; Immune Sera; Male; Naloxone; Naltrexone; Pituitary Gland; Rats; Rats, Inbred Strains; Thyrotropin-Releasing Hormone

1984
Counteraction by naltrexone of stress-induced inhibition of TSH release: role of noradrenergic system.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1984, Volume: 177, Issue:2

    Topics: Animals; Ditiocarb; Kinetics; Male; Morphine; Naloxone; Naltrexone; Norepinephrine; Pituitary Gland, Anterior; Rats; Rats, Inbred Strains; Stress, Physiological; Thyrotropin

1984
Cold water stress analgesia in rats: differential effects of naltrexone.
    Physiology & behavior, 1984, Volume: 32, Issue:4

    Topics: Animals; Arousal; Body Temperature Regulation; Cold Temperature; Male; Naloxone; Naltrexone; Nociceptors; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Opioid; Stress, Physiological

1984
Naltrexone modulates body and brain development in rats: a role for endogenous opioid systems in growth.
    Life sciences, 1984, Nov-12, Volume: 35, Issue:20

    Topics: Aging; Animals; Body Weight; Brain; Female; Male; Naloxone; Naltrexone; Organ Size; Rats; Rats, Inbred Strains; Receptors, Opioid

1984
Opiate-receptor interactions on single locus coeruleus neurones.
    Molecular pharmacology, 1984, Volume: 26, Issue:3

    Topics: Action Potentials; Animals; Enkephalin, Methionine; In Vitro Techniques; Locus Coeruleus; Morphine Derivatives; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Neurons; Rats; Receptors, Opioid

1984
Mu and delta opioid receptor interactions in a rat model of drug induced seizures.
    Proceedings of the Western Pharmacology Society, 1984, Volume: 27

    Topics: Animals; Disease Models, Animal; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Seizures

1984
Effects of ethanol and naltrexone on free-operant avoidance behavior in rats.
    Pharmacology, biochemistry, and behavior, 1984, Volume: 21, Issue:3

    Topics: Animals; Avoidance Learning; Conditioning, Operant; Drug Combinations; Ethanol; Food Deprivation; Male; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid

1984
Clonidine hydrochloride detoxification from methadone treatment--the value of naltrexone aftercare.
    Advances in alcohol & substance abuse, 1984,Spring, Volume: 3, Issue:3

    Topics: Adult; Aftercare; Attitude to Health; Clonidine; Female; Follow-Up Studies; Humans; Male; Methadone; Naloxone; Naltrexone; Opioid-Related Disorders; Substance Withdrawal Syndrome

1984
Hyperthermic response of the cat to intraventricular injection of the opioid delta-receptor agonist D-Ala2-D-Leu5-enkephalin.
    Brain research bulletin, 1984, Volume: 13, Issue:2

    Topics: Animals; Body Temperature; Body Temperature Regulation; Cats; Drug Tolerance; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Injections, Intraventricular; Morphine; Naloxone; Naltrexone; Receptors, Opioid; Receptors, Opioid, delta

1984
Comparative antagonism by naltrexone and naloxone of mu, kappa, and delta agonists.
    European journal of pharmacology, 1984, Sep-03, Volume: 104, Issue:1-2

    Topics: Animals; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vas Deferens

1984
3-[18F]Acetylcyclofoxy: a useful probe for the visualization of opiate receptors in living animals.
    FEBS letters, 1984, Nov-19, Volume: 177, Issue:2

    Topics: Animals; Autoradiography; Binding, Competitive; Brain; Cell Membrane; Fluorine; Naloxone; Naltrexone; Radioisotopes; Rats; Receptors, Opioid; Tissue Distribution

1984
Chronic naloxone increases opiate binding in SHR and WKY rats.
    Neurochemical research, 1984, Volume: 9, Issue:12

    Topics: Aging; Animals; Blood Pressure; Brain; Female; Kinetics; Male; Naloxone; Naltrexone; Narcotics; Pregnancy; Prenatal Exposure Delayed Effects; Radioimmunoassay; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Opioid

1984
Chronic blockade of opiate receptors: influence on reproduction and body weight in female rats.
    Neuropeptides, 1984, Volume: 5, Issue:1-3

    Topics: Animals; Body Weight; Estrus; Female; Luteinizing Hormone; Naloxone; Naltrexone; Pregnancy; Rats; Rats, Inbred Strains; Receptors, Opioid; Reproduction

1984
Core temperature changes following administration of naloxone and naltrexone to rats exposed to hot and cold ambient temperatures. Evidence for the physiological role of endorphins in hot and cold acclimatization.
    The Journal of pharmacy and pharmacology, 1980, Volume: 32, Issue:6

    Topics: Animals; Body Temperature Regulation; Cold Temperature; Endorphins; Hot Temperature; Male; Naloxone; Naltrexone; Rats

1980
Interactions between narcotic agonists, partial agonists and antagonists evaluated by schedule-controlled behavior.
    The Journal of pharmacology and experimental therapeutics, 1980, Volume: 213, Issue:3

    Topics: Analgesics, Opioid; Animals; Conditioning, Operant; Drug Interactions; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Reaction Time; Reinforcement Schedule

1980
Effects of naltrexone and prolyl-leucyl-glycinamide on drug-induced tremor and rigidity in the rat.
    Neuropharmacology, 1981, Volume: 20, Issue:8

    Topics: Animals; Female; Injections, Intraventricular; Morphine; MSH Release-Inhibiting Hormone; Muscle Rigidity; Muscle Tonus; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Time Factors; Tremor; Tremorine

1981
Anorexic effects of naltrexone in man.
    Lancet (London, England), 1982, Feb-13, Volume: 1, Issue:8268

    Topics: Adolescent; Adult; Anorexia; Body Weight; Feeding and Eating Disorders; Female; Humans; Male; Naloxone; Naltrexone

1982
Pharmacological characterization in vivo of the novel opiate, beta-funaltrexamine.
    The Journal of pharmacology and experimental therapeutics, 1982, Volume: 220, Issue:3

    Topics: Acetates; Acetic Acid; Analgesics, Opioid; Animals; Drug Interactions; Female; Male; Mice; Morphine; Nalorphine; Naloxone; Naltrexone; Narcotics; Pain; Reaction Time

1982
Naloxone: analeptic action unrelated to opiate receptor antagonism?
    Anesthesiology, 1982, Volume: 56, Issue:4

    Topics: Animals; Central Nervous System Stimulants; Halothane; Injections, Intraventricular; Ketamine; Male; Naloxone; Naltrexone; Pentobarbital; Rats; Rats, Inbred Strains; Receptors, Opioid; Sleep

1982
Prevention of late fentanyl-induced respiratory depression after the injection of opiate antagonists naltrexone and S-20682: comparison with naloxone.
    British journal of anaesthesia, 1983, Volume: 55, Issue:1

    Topics: Animals; Carbon Dioxide; Depression, Chemical; Dogs; Electroencephalography; Fentanyl; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Oxygen; Partial Pressure; Respiration; Time Factors

1983
Opioid peptides inhibit intestinal transit in the rat by a central mechanism.
    European journal of pharmacology, 1982, Nov-05, Volume: 85, Issue:1

    Topics: Animals; beta-Endorphin; Central Nervous System; Diarrhea; Dynorphins; Endorphins; Female; Gastrointestinal Motility; Intestine, Small; Naloxone; Naltrexone; Rats; Rats, Inbred Strains

1982
Application of an irreversible opiate antagonist (beta-FNA, beta-funal-trexamine) to demonstrate dynorphin selectivity for K-opioid sites.
    Life sciences, 1982, Nov-29, Volume: 31, Issue:22

    Topics: Animals; Binding, Competitive; Dose-Response Relationship, Drug; Dynorphins; Electric Stimulation; Endorphins; Guinea Pigs; Morphine Derivatives; Muscle, Smooth; Naloxone; Naltrexone; Receptors, Opioid; Time Factors

1982
Preparation of brain membranes containing a single type of opioid receptor highly selective for dynorphin.
    Proceedings of the National Academy of Sciences of the United States of America, 1982, Volume: 79, Issue:23

    Topics: Animals; Brain Chemistry; Cell Membrane; Dynorphins; Endorphins; Guinea Pigs; Ligands; Naloxone; Naltrexone; Receptors, Opioid

1982
Relative involvement of mu, kappa and delta receptor mechanisms in opiate-mediated antinociception in mice.
    The Journal of pharmacology and experimental therapeutics, 1983, Volume: 224, Issue:3

    Topics: Acetates; Acetic Acid; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Hot Temperature; Male; Mice; Naloxone; Naltrexone; Pain; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu

1983
Naltrexone metabolism and sustained release following administration of an insoluble complex to rhesus monkeys and guinea-pigs.
    The Journal of pharmacy and pharmacology, 1983, Volume: 35, Issue:1

    Topics: Animals; Biotransformation; Chromatography, Thin Layer; Delayed-Action Preparations; Female; Guinea Pigs; Hydrolysis; Macaca mulatta; Male; Naloxone; Naltrexone; Species Specificity; Time Factors

1983
Comparison of dynorphin-selective Kappa receptors in mouse vas deferens and guinea pig ileum. Spare receptor fraction as a determinant of potency.
    Molecular pharmacology, 1983, Volume: 23, Issue:1

    Topics: Animals; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Guinea Pigs; Ileum; Male; Mice; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Receptors, Opioid; Receptors, Opioid, kappa; Structure-Activity Relationship; Vas Deferens

1983
Opioid receptor selectivity of dynorphin gene products.
    The Journal of pharmacology and experimental therapeutics, 1984, Volume: 228, Issue:1

    Topics: Animals; Dynorphins; Endorphins; Enkephalin, Leucine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Naloxone; Naltrexone; Peptide Fragments; Protein Precursors; Receptors, Opioid

1984
Receptor preference of dynorphin A fragments in the mouse vas deferens determined by different techniques.
    The Journal of pharmacology and experimental therapeutics, 1984, Volume: 230, Issue:1

    Topics: Animals; Drug Tolerance; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Fentanyl; Male; Mice; Naloxone; Naltrexone; Peptide Fragments; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vas Deferens

1984
Neurotransmitters and biphasic respiratory response to hypoxia.
    Journal of applied physiology: respiratory, environmental and exercise physiology, 1984, Volume: 57, Issue:1

    Topics: Adenosine; Aminophylline; Animals; Animals, Newborn; Endorphins; Hyperventilation; Hypoxia; Naloxone; Naltrexone; Neurotransmitter Agents; Phrenic Nerve; Respiration; Swine

1984
Which opioid receptor mechanism modulates feeding?
    Appetite, 1984, Volume: 5, Issue:1

    Topics: Animals; Azocines; Diprenorphine; Dynorphins; Endorphins; Feeding Behavior; Humans; Mice; Naloxone; Naltrexone; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, sigma

1984
The role of opioid receptor sub-types in tifluadom-induced feeding.
    The Journal of pharmacy and pharmacology, 1984, Volume: 36, Issue:10

    Topics: Animals; Benzodiazepines; Benzodiazepinones; Benzomorphans; Convulsants; Eating; Enkephalin, Leucine; Flumazenil; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Stereoisomerism

1984
Morphine analgesia after intrathecal administration of a narcotic agonist, chloroxymorphamine and antagonist, chlornaltrexamine.
    European journal of pharmacology, 1980, Nov-07, Volume: 68, Issue:1

    Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Interactions; Hydromorphone; Injections, Spinal; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Nitrogen Mustard Compounds; Oxymorphone; Rats

1980
Pharmacological studies with an alkylating narcotic agonist, chloroxymorphamine, and antagonist, chlornaltrexamine.
    The Journal of pharmacology and experimental therapeutics, 1980, Volume: 213, Issue:3

    Topics: Analgesics; Animals; Brain; Hydromorphone; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Nitrogen Mustard Compounds; Oxymorphone

1980
Irreversible opiate agonists and antagonists: the 14-hydroxydihydromorphinone azines.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1982, Volume: 2, Issue:5

    Topics: Animals; Brain; Cell Membrane; Dihydromorphine; Drug Stability; Hydromorphone; Kinetics; Naloxone; Naltrexone; Oxymorphone; Receptors, Opioid; Structure-Activity Relationship

1982
A case of episodic flushing and organic psychosis: reversal by opiate antagonists.
    Annals of internal medicine, 1983, Volume: 98, Issue:1

    Topics: Adult; Anxiety Disorders; Female; Histamine Release; Humans; Mast Cells; Naloxone; Naltrexone; Neurocognitive Disorders; Pain; Skin; Vasodilator Agents

1983
Quaternary opiate antagonists lower blood pressure and inhibit leucine-enkephalin responses.
    European journal of pharmacology, 1983, Nov-25, Volume: 95, Issue:3-4

    Topics: Animals; Blood Pressure; Dogs; Dose-Response Relationship, Drug; Enkephalin, Leucine; Heart Rate; Hydromorphone; Naloxone; Naltrexone; Oxymorphone; Quaternary Ammonium Compounds

1983
Diastereomeric 6-desoxy-6-spiro-alpha-methylene-gamma-butyrolactone derivatives of naltrexone and oxymorphone. Selective irreversible inhibition of naltrexone binding in an opioid receptor preparation by a conformationally restricted michael acceptor liga
    Journal of medicinal chemistry, 1984, Volume: 27, Issue:12

    Topics: Animals; Brain; Cell Membrane; Chromatography, Thin Layer; Hydromorphone; Indicators and Reagents; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Molecular Conformation; Naloxone; Naltrexone; Narcotic Antagonists; Optical Rotation; Oxymorphone; Rats; Rats, Inbred Strains; Receptors, Opioid; Structure-Activity Relationship

1984
Naloxone-induced increases in serum luteinizing hormone in the male: mechanisms of action.
    The Journal of pharmacology and experimental therapeutics, 1980, Volume: 212, Issue:3

    Topics: Animals; Binding, Competitive; Castration; Dihydrotestosterone; Gonadotropin-Releasing Hormone; Hypothalamus; In Vitro Techniques; Luteinizing Hormone; Male; Naloxone; Naltrexone; Pituitary Gland, Anterior; Rats; Receptors, Androgen; Receptors, Opioid; Steroids

1980
Selective protection of stereospecific enkephalin and opiate binding against inactivation by N-ethylmaleimide: evidence for two classes of opiate receptors.
    Proceedings of the National Academy of Sciences of the United States of America, 1980, Volume: 77, Issue:1

    Topics: Animals; Binding, Competitive; Brain; Endorphins; Enkephalins; Ethylmaleimide; Kinetics; Ligands; Male; Morphine; Naloxone; Naltrexone; Rats; Receptors, Opioid

1980
Opiate receptors: problems of definition and characterization.
    Advances in biochemical psychopharmacology, 1980, Volume: 21

    Topics: Animals; Binding Sites; Brain; Caudate Nucleus; Cyclazocine; Endorphins; Enkephalins; Hippocampus; Humans; Morphine; Naloxone; Naltrexone; Receptors, Opioid

1980
The effects of opiate agonists on growth hormone and prolactin release in rats.
    Federation proceedings, 1980, Volume: 39, Issue:8

    Topics: Animals; Apomorphine; Enkephalins; Growth Hormone; Male; Methadone; Morphine; Naloxone; Naltrexone; Parasympathomimetics; Prolactin; Rats; Receptors, Cholinergic; Receptors, Dopamine; Receptors, Opioid; Secretory Rate

1980
Electroacupuncture analgesia is mediated by stereospecific opiate receptors and is reversed by antagonists of type I receptors.
    Life sciences, 1980, Feb-25, Volume: 26, Issue:8

    Topics: Acupuncture Therapy; Analgesia; Animals; Cyclazocine; Diprenorphine; Electric Stimulation; Female; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Stereoisomerism; Time Factors

1980
Possible role of an endogenous opiate in the cardiovascular effects of central alpha adrenoceptor stimulation in spontaneously hypertensive rats.
    The Journal of pharmacology and experimental therapeutics, 1980, Volume: 214, Issue:1

    Topics: Anesthesia; Animals; Blood Pressure; Clonidine; Dose-Response Relationship, Drug; Drug Interactions; Endorphins; Heart Rate; Hypertension; Male; Methyldopa; Morphine; Naloxone; Naltrexone; Rats; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Receptors, Opioid; Time Factors; Yohimbine

1980
Influence of morphine and naltrexone on the intraocular pressure of conscious cynomolgus monkeys (Macaca fascicularis).
    Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. Albrecht von Graefe's archive for clinical and experimental ophthalmology, 1980, Volume: 214, Issue:1

    Topics: Animals; Drug Combinations; Intraocular Pressure; Macaca; Macaca fascicularis; Morphine; Naloxone; Naltrexone; Receptors, Opioid

1980
Inhibition of growth in young mice treated with pentazocine: reversal by naltrexone.
    European journal of pharmacology, 1980, Aug-29, Volume: 66, Issue:2-3

    Topics: Animals; Body Weight; Brain; Dose-Response Relationship, Drug; Growth; Liver; Mice; Muscle Proteins; Naloxone; Naltrexone; Pentazocine; Protein Biosynthesis; Receptors, Opioid

1980
Opioid peptides and their receptors.
    Progress in biochemical pharmacology, 1980, Volume: 16

    Topics: Animals; Brain; Dogs; Endorphins; Enkephalins; Guinea Pigs; Ileum; Male; Mice; Naloxone; Naltrexone; Receptors, Opioid; Vas Deferens

1980
Opiate antagonists and long-term analgesic reaction induced by inescapable shock in rats.
    Journal of comparative and physiological psychology, 1980, Volume: 94, Issue:6

    Topics: Animals; Dose-Response Relationship, Drug; Electroshock; Humans; Naloxone; Naltrexone; Nociceptors; Rats; Reaction Time; Receptors, Opioid; Stress, Physiological

1980
Isolation of selective 3H-chlornaltrexamine-bound complexes, possible opioid receptor components in brains of mice.
    Life sciences, 1980, Dec-01, Volume: 27, Issue:22

    Topics: Animals; Brain; Chromatography, Gel; Dextrorphan; In Vitro Techniques; Mice; Naloxone; Naltrexone; Nitrogen Mustard Compounds; Receptors, Opioid

1980
ACTH mediation of learned fear: blockade by naloxone and naltrexone.
    Physiology & behavior, 1980, Volume: 25, Issue:6

    Topics: Adrenocorticotropic Hormone; Animals; Avoidance Learning; Conditioning, Psychological; Drug Antagonism; Fear; Male; Naloxone; Naltrexone; Rats

1980
Quaternary naltrexone: evidence for the central mediation of discriminative stimulus effects of narcotic agonists and antagonists.
    The Journal of pharmacology and experimental therapeutics, 1981, Volume: 217, Issue:3

    Topics: Animals; Brain; Columbidae; Discrimination, Psychological; Etorphine; Macaca mulatta; Male; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Receptors, Opioid

1981
The irreversible narcotic antagonistic and reversible agonistic properties of the fumaramate methyl ester derivative of naltrexone.
    European journal of pharmacology, 1981, Apr-09, Volume: 70, Issue:4

    Topics: Affinity Labels; Animals; Ileum; Male; Mice; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Oxymorphone; Receptors, Opioid; Structure-Activity Relationship

1981
Chronic lithium administration alters the interaction between opiate antagonists and opiate receptors in vivo.
    Neuropharmacology, 1981, Volume: 20, Issue:6

    Topics: Animals; Behavior, Animal; Lithium; Male; Membranes; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Reaction Time; Receptors, Opioid; Time Factors

1981
Different opioid systems may participate in post-electro-convulsive shock (ECS) analgesia and catalepsy.
    Brain research, 1981, Aug-31, Volume: 219, Issue:2

    Topics: Animals; Drug Tolerance; Electroshock; Male; Morphine; Motor Activity; Naloxone; Naltrexone; Nociceptors; Rats; Receptors, Opioid

1981
Antagonism by chlornaltrexamine of some effects of delta 9-tetrahydrocannabinol in rats.
    European journal of pharmacology, 1981, Mar-12, Volume: 70, Issue:2

    Topics: Analgesia; Animals; Dronabinol; Drug Tolerance; Humans; Hypothermia; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Nitrogen Mustard Compounds; Rats; Receptors, Opioid; Substance-Related Disorders

1981
Seasonal variation in the apparent number of binding sites for 3H-opioid agonists and antagonists.
    Life sciences, 1981, Jun-08, Volume: 28, Issue:23

    Topics: Animals; Binding Sites; Brain; Dihydromorphine; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Kinetics; Male; Mice; Morphinans; Morphine; Naloxone; Naltrexone; Receptors, Opioid; Seasons

1981
Characterization of the kappa-subtype of the opiate receptor in the guinea-pig brain.
    British journal of pharmacology, 1981, Volume: 73, Issue:4

    Topics: Animals; Benzomorphans; Binding Sites; Binding, Competitive; Brain; Cyclazocine; Dihydromorphine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Guinea Pigs; Naloxone; Naltrexone; Narcotics; Phenoxybenzamine; Receptors, Opioid

1981
Gamma-melanotropin and brain function.
    Ciba Foundation symposium, 1981, Volume: 81

    Topics: Adrenocorticotropic Hormone; Animals; Behavior, Animal; beta-Endorphin; Biological Assay; Brain; Endorphins; Guinea Pigs; Melanocyte-Stimulating Hormones; Muscle Contraction; Naloxone; Naltrexone; Pituitary Hormones, Anterior; Pro-Opiomelanocortin; Protein Precursors; Rats; Receptors, Opioid

1981
Irreversible inactivation of the opiate receptors in the neuroblastoma x glioma hybrid NG108-15 by chlornaltrexamine.
    Molecular pharmacology, 1981, Volume: 20, Issue:1

    Topics: Animals; Cyclic AMP; Enkephalin, Methionine; Enkephalins; Glioma; Hybrid Cells; Mice; Naloxone; Naltrexone; Neoplasms, Experimental; Neuroblastoma; Nitrogen Mustard Compounds; Prostaglandins E, Synthetic; Rats; Receptors, Opioid

1981
Effects of opioid peptides on thermoregulation.
    Federation proceedings, 1981, Volume: 40, Issue:13

    Topics: Animals; beta-Endorphin; Body Temperature Regulation; Cats; Cattle; Endorphins; Enkephalin, Methionine; Enkephalins; Mice; Naloxone; Naltrexone; Narcotics; Rats; Structure-Activity Relationship

1981
Naltrexone reduces weight gain, alters "beta-endorphin", and reduces insulin output from pancreatic islets of genetically obese mice.
    Peptides, 1980,Winter, Volume: 1, Issue:4

    Topics: Animals; beta-Endorphin; Body Weight; Endorphins; Insulin; Insulin Secretion; Islets of Langerhans; Mice; Mice, Obese; Naloxone; Naltrexone; Obesity; Pituitary Gland; Receptors, Opioid

1980
ACTH-induced grooming involves high-affinity opiate receptors.
    Behavioral and neural biology, 1981, Volume: 31, Issue:1

    Topics: Adrenocorticotropic Hormone; Animals; Grooming; Muridae; Naloxone; Naltrexone; Receptors, Opioid

1981
Effect of naltrexone on regional brain oxygen consumption in the cat.
    Brain research, 1982, Feb-11, Volume: 233, Issue:2

    Topics: Animals; Brain; Cats; Cerebrovascular Circulation; Female; Male; Naloxone; Naltrexone; Oxygen Consumption; Receptors, Opioid

1982
Naltrexone improves survival rate and cardiovascular function in canine hemorrhagic shock.
    The Journal of pharmacology and experimental therapeutics, 1982, Volume: 220, Issue:3

    Topics: Animals; Dogs; Dose-Response Relationship, Drug; Drug Tolerance; Female; Hemodynamics; Male; Morphine; Naloxone; Naltrexone; Receptors, Opioid; Shock, Hemorrhagic

1982
Stereospecific accumulation of dihydromorphine and naltrexone by corpus striatal slices of morphine-dependent mice.
    Neuropharmacology, 1982, Volume: 21, Issue:1

    Topics: Animals; Binding, Competitive; Corpus Striatum; Dihydromorphine; Humans; In Vitro Techniques; Male; Mice; Morphine Dependence; Morphine Derivatives; Naloxone; Naltrexone; Receptors, Opioid; Stereoisomerism; Substance Withdrawal Syndrome

1982
Effects of naloxone and naltrexone on locomotor activity in C57BL/6 and DBA/2 mice.
    Pharmacology, biochemistry, and behavior, 1982, Volume: 16, Issue:4

    Topics: Animals; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Motor Activity; Naloxone; Naltrexone; Receptors, Opioid; Species Specificity

1982
Antagonism of morphine-induced behavioral suppression by opiate receptor alkylators.
    Pharmacology, biochemistry, and behavior, 1982, Volume: 16, Issue:4

    Topics: Amphetamine; Animals; Brain; Conditioning, Operant; Exploratory Behavior; Male; Morphine; Muridae; Naloxone; Naltrexone; Nitrogen Mustard Compounds; Nociceptors; Receptors, Opioid

1982
Opiate antagonists stimulate affiliative behaviour in monkeys.
    Pharmacology, biochemistry, and behavior, 1982, Volume: 16, Issue:4

    Topics: Animals; Behavior, Animal; Cercopithecidae; Eating; Female; Grooming; Hydrocortisone; Luteinizing Hormone; Male; Motor Activity; Naloxone; Naltrexone; Prolactin; Receptors, Opioid; Social Behavior; Stimulation, Chemical; Sulpiride; Testosterone

1982
Stimulus properties of opioids with mixed agonist and antagonist activity.
    Federation proceedings, 1982, Volume: 41, Issue:7

    Topics: Animals; Conditioning, Psychological; Cyclazocine; Dogs; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Phencyclidine; Rats; Receptors, Opioid; Saimiri

1982
Interactions between narcotic agonists, partial agonists andd antagonists evaluated by punished an unpunished behavior in the rat.
    Psychopharmacology, 1982, Volume: 76, Issue:2

    Topics: Animals; Conditioning, Psychological; Cyclazocine; Dose-Response Relationship, Drug; Ethylketocyclazocine; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Phenazocine; Punishment; Rats; Rats, Inbred Strains; Receptors, Opioid

1982
Pharmacological profiles of beta-funaltrexamine (beta-FNA) and beta-chlornaltrexamine (beta-CNA) on the mouse vas deferens preparation.
    European journal of pharmacology, 1982, Jun-04, Volume: 80, Issue:4

    Topics: Animals; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Mice; Mice, Inbred Strains; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Vas Deferens

1982
Opiate, enkephalin, and endorphin analgesia: relations to a single subpopulation of opiate receptors.
    Neurology, 1981, Volume: 31, Issue:10

    Topics: Analgesia; Animals; Humans; Lethal Dose 50; Morphine; Muridae; Naloxone; Naltrexone; Oxymorphone; Receptors, Opioid; Respiration; Respiratory Insufficiency

1981
Naltrexone-insensitive facilitation and naltrexone-sensitive inhibition of passive avoidance behavior of the ACTH-(4-9) analog (ORG 2766) are located in two different parts of the molecule.
    European journal of pharmacology, 1982, Jul-16, Volume: 81, Issue:3

    Topics: Adrenocorticotropic Hormone; Animals; Avoidance Learning; Drug Interactions; Injections, Intraventricular; Injections, Subcutaneous; Male; Naloxone; Naltrexone; Peptide Fragments; Rats; Rats, Inbred Strains

1982
Potential affinity labels for the opiate receptor based on fentanyl and related compounds.
    Journal of medicinal chemistry, 1982, Volume: 25, Issue:8

    Topics: Affinity Labels; Animals; Chemical Phenomena; Chemistry; Fentanyl; In Vitro Techniques; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid

1982
Methadone-induced endorphin dysfunction in addicts.
    NIDA research monograph, 1982, Volume: 41

    Topics: Adrenocorticotropic Hormone; Brain; Endorphins; Humans; Hydrocortisone; Male; Methadone; Naloxone; Naltrexone; Opioid-Related Disorders; Receptors, Opioid; Substance Withdrawal Syndrome

1982
Naltrexone-induced opiate receptor supersensitivity.
    Brain research, 1982, Aug-12, Volume: 245, Issue:2

    Topics: Animals; Brain; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Female; Guanosine Triphosphate; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid

1982
Intraseptally injected opiate agents: effects on morphine-induced behaviour of cats.
    Pharmacology, biochemistry, and behavior, 1982, Volume: 17, Issue:2

    Topics: Animals; Behavior, Animal; beta-Endorphin; Cats; Endorphins; Enkephalin, Methionine; Fentanyl; Morphine; Naloxone; Naltrexone; Narcotics; Receptors, Opioid; Septal Nuclei; Septum Pellucidum

1982
Involvement of both adrenergic and cholinergic receptors in the cardiovascular effects of naloxone during hemorrhagic hypotension in the conscious rabbit.
    Journal of the autonomic nervous system, 1982, Volume: 6, Issue:2

    Topics: Adrenergic Fibers; Animals; Atropine; Blood Pressure; Efferent Pathways; Heart Rate; Hemodynamics; Hemorrhage; Hypotension; Male; Naloxone; Naltrexone; Parasympathetic Nervous System; Phentolamine; Propranolol; Rats; Receptors, Adrenergic; Receptors, Cholinergic; Receptors, Opioid

1982
Extent and control of shock affects naltrexone sensitivity of stress-induced analgesia and reactivity to morphine.
    Pharmacology, biochemistry, and behavior, 1982, Volume: 17, Issue:5

    Topics: Animals; Dose-Response Relationship, Drug; Electroshock; Helplessness, Learned; Humans; Male; Morphine; Naloxone; Naltrexone; Nociceptors; Rats; Receptors, Opioid; Sensory Thresholds; Stress, Physiological

1982
Enhancement of osmotic- and hypovolemic-induced drinking by chlordiazepoxide in rats is blocked by naltrexone.
    Pharmacology, biochemistry, and behavior, 1982, Volume: 17, Issue:5

    Topics: Animals; Chlordiazepoxide; Dose-Response Relationship, Drug; Drinking; Male; Muridae; Naloxone; Naltrexone; Polyethylene Glycols; Receptors, Opioid; Saline Solution, Hypertonic; Water-Electrolyte Balance

1982
Protection of opiate receptors in NG108-15 against modification by N-ethylmaleimide.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1983, Volume: 3, Issue:1

    Topics: Animals; Cell Line; Dithiothreitol; Enkephalin, Methionine; Ethylmaleimide; Glioma; Hybrid Cells; Kinetics; Mice; Naloxone; Naltrexone; Neuroblastoma; Rats; Receptors, Opioid; Sulfhydryl Reagents

1983
Hibernation "trigger": opioid-like inhibitory action on brain function of the monkey.
    Pharmacology, biochemistry, and behavior, 1982, Volume: 17, Issue:6

    Topics: Animals; Body Temperature Regulation; Brain; Eating; Heart Rate; Hibernation; Injections, Intraventricular; Macaca mulatta; Male; Marmota; Naloxone; Naltrexone; Peptides; Proteins; Receptors, Opioid

1982
Effects of opiate antagonists and putative mu- and kappa-agonists on milk intake in rat and squirrel monkey.
    Pharmacology, biochemistry, and behavior, 1982, Volume: 17, Issue:6

    Topics: Animals; Buprenorphine; Cyclazocine; Diazepam; Diprenorphine; Drinking; Ethylketocyclazocine; Etorphine; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Saimiri; Taste

1982
Naloxone enhancement of memory processes: effects of other opiate antagonists.
    Behavioral and neural biology, 1982, Volume: 35, Issue:4

    Topics: Animals; Avoidance Learning; Diprenorphine; Female; Male; Memory; Mental Recall; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Retention, Psychology

1982
Blockade of morphine dependence-related enhancement of secretory protein synthesis in the pons-medulla and striatum-septum by naltrexone.
    Neuropharmacology, 1983, Volume: 22, Issue:2

    Topics: Animals; Body Temperature; Body Weight; Brain; Corpus Striatum; Humans; Male; Medulla Oblongata; Morphine Dependence; Naloxone; Naltrexone; Nerve Tissue Proteins; Pons; Rats; Rats, Inbred Strains; Receptors, Opioid

1983
Determination of the relative involvement of mu-opioid receptors in opioid-induced depression of respiratory rate by use of beta-funaltrexamine.
    European journal of pharmacology, 1983, Jan-28, Volume: 87, Issue:1

    Topics: Analgesics; Animals; Depression, Chemical; Drug Interactions; Female; Injections, Intraventricular; Male; Mice; Naloxone; Naltrexone; Narcotics; Reaction Time; Receptors, Opioid; Receptors, Opioid, mu; Respiration

1983
Naltrexone-sensitive behavioral actions of the ACTH 4-9 analog (Org 2766).
    Life sciences, 1983, May-09, Volume: 32, Issue:19

    Topics: Adrenocorticotropic Hormone; Animals; Avoidance Learning; Behavior, Animal; beta-Endorphin; Electric Stimulation; Endorphins; Enkephalin, Methionine; Grooming; Male; Naloxone; Naltrexone; Oligopeptides; Peptide Fragments; Rats; Rats, Inbred Strains; Self Stimulation

1983
Naltrexone blocks the response-latency increasing effects but not the discriminative effects of diazepam in rats.
    European journal of pharmacology, 1983, Mar-18, Volume: 88, Issue:1

    Topics: Animals; Diazepam; Discrimination Learning; Dose-Response Relationship, Drug; Drug Interactions; Male; Naloxone; Naltrexone; Rats; Rats, Inbred F344; Reaction Time; Receptors, Cell Surface; Receptors, GABA-A

1983
Opiate antagonists overcome the learned helplessness effect but impair competent escape performance.
    Physiology & behavior, 1983, Volume: 30, Issue:5

    Topics: Animals; Dose-Response Relationship, Drug; Electroshock; Escape Reaction; Helplessness, Learned; Humans; Male; Muridae; Naloxone; Naltrexone; Reaction Time; Receptors, Opioid

1983
Importance of C-6 chirality in conferring irreversible opioid antagonism to naltrexone-derived affinity labels.
    Journal of medicinal chemistry, 1983, Volume: 26, Issue:9

    Topics: Affinity Labels; Animals; Guinea Pigs; Ileum; Male; Mice; Naloxone; Naltrexone; Receptors, Opioid; Stereoisomerism; Vas Deferens

1983
An opiate binding site in the rat brain is highly selective for 4,5-epoxymorphinans.
    Science (New York, N.Y.), 1983, Sep-16, Volume: 221, Issue:4616

    Topics: Animals; Brain Chemistry; Dihydromorphine; Diprenorphine; Morphine; Nalorphine; Naloxone; Naltrexone; Rats; Receptors, Opioid; Sodium; Tissue Distribution

1983
Naltrexone fails to antagonize the sigma effects of PCP and SKF 10,047 in the dog.
    European journal of pharmacology, 1983, Sep-02, Volume: 92, Issue:3-4

    Topics: Animals; Body Temperature; Dogs; Female; Heart Rate; Morphine; Naloxone; Naltrexone; Paraplegia; Phenazocine; Phencyclidine; Receptors, Opioid; Receptors, sigma; Reflex

1983
Effect of chronic naltrexone and methadone administration on brain immunoreactive beta-endorphin in the rat.
    Neuroendocrinology, 1983, Volume: 37, Issue:4

    Topics: Animals; beta-Endorphin; Brain Chemistry; Endorphins; Hypothalamus; Male; Methadone; Naloxone; Naltrexone; Radioimmunoassay; Rats; Rats, Inbred Strains

1983
Morphine exacerbates anaphylactic shock in mice by stimulating central opiate receptors.
    Neuroscience letters, 1983, Sep-30, Volume: 40, Issue:2

    Topics: Anaphylaxis; Animals; Azocines; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Naltrexone; Receptors, Opioid

1983
Naltrexone modulates growth in infant rats.
    Life sciences, 1983, Dec-12, Volume: 33, Issue:24

    Topics: Animals; Animals, Newborn; Body Weight; Ear, External; Eye; Female; Growth; Hair; Male; Motor Activity; Naloxone; Naltrexone; Organ Size; Rats; Receptors, Opioid

1983
Chronic naltrexone increases opiate binding in brain and produces supersensitivity to morphine in the locus coeruleus of the rat.
    Brain research, 1983, Dec-19, Volume: 289, Issue:1-2

    Topics: Animals; Brain; Etorphine; Locus Coeruleus; Male; Morphine; Naloxone; Naltrexone; Narcotics; Neurons; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Synaptic Transmission; Yohimbine

1983
Evidence for delta-receptor involvement in the post-ictal antinociceptive responses to electroconvulsive shock in rats.
    Life sciences, 1983, Volume: 33 Suppl 1

    Topics: Animals; Electroshock; Enkephalin, Leucine; Escape Reaction; Hot Temperature; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta

1983
Multiple opioid receptors: evidence for mu-delta binding site interactions in endotoxic shock.
    Life sciences, 1983, Volume: 33 Suppl 1

    Topics: Animals; Blood Pressure; Enkephalin, Leucine; Heart Rate; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pulse; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Shock, Septic

1983
Repeated administration of naltrexone and diprenorphine decreases food intake and body weight in squirrel monkeys.
    Life sciences, 1984, Jan-02, Volume: 34, Issue:1

    Topics: Animals; Body Weight; Diprenorphine; Dose-Response Relationship, Drug; Drinking; Eating; Female; Humans; Male; Morphinans; Naloxone; Naltrexone; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Saimiri; Salivation

1984
Effect of beta-FNA on opiate receptor binding: preliminary evidence for two types of mu receptors.
    European journal of pharmacology, 1983, Nov-11, Volume: 95, Issue:1-2

    Topics: Animals; Brain; In Vitro Techniques; Naloxone; Naltrexone; Oxymorphone; Rats; Receptors, Opioid; Receptors, Opioid, mu

1983
ICI 154,129, a delta-opioid receptor antagonist raises seizure threshold in rats.
    European journal of pharmacology, 1984, Jan-13, Volume: 97, Issue:1-2

    Topics: Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Seizures

1984
Effects of chronic naltrexone on amphetamine locomotor activity.
    Substance and alcohol actions/misuse, 1983, Volume: 4, Issue:4

    Topics: Amphetamine; Animals; Drug Interactions; Male; Motor Activity; Naloxone; Naltrexone; Noise; Rats; Receptors, Opioid; Stress, Physiological

1983
Affinity chromatography of solubilized opioid binding sites using CH-Sepharose modified with a new naltrexone derivative.
    Biochemical and biophysical research communications, 1984, Mar-15, Volume: 119, Issue:2

    Topics: Animals; Bufo marinus; Cattle; Cell Membrane; Chromatography, Affinity; Corpus Striatum; Diprenorphine; Female; Male; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Sepharose

1984
Naltrexone prevents footshock-induced performance deficit in rats.
    Life sciences, 1984, May-21, Volume: 34, Issue:21

    Topics: Analgesia; Animals; Avoidance Learning; Electroshock; Male; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid

1984
Visualization of opiate receptor upregulation by light microscopy autoradiography.
    Proceedings of the National Academy of Sciences of the United States of America, 1984, Volume: 81, Issue:12

    Topics: Animals; Autoradiography; Brain; Brain Chemistry; Brain Mapping; Enkephalin, Methionine; Male; Naloxone; Naltrexone; Rats; Receptors, Opioid

1984
Differential role of the opioid mu and delta receptors in the activation of prolactin (PRL) and growth hormone (GH) secretion by morphine in the male rat.
    Life sciences, 1984, May-07, Volume: 34, Issue:19

    Topics: Animals; Drug Interactions; Enkephalin, Leucine; Growth Hormone; Injections, Intraventricular; Male; Morphine; Naloxone; Naltrexone; Prolactin; Rats; Rats, Inbred Strains; Receptors, Opioid

1984
Use of naltrexone to extinguish opioid-conditioned responses.
    The Journal of clinical psychiatry, 1984, Volume: 45, Issue:9 Pt 2

    Topics: Adult; Combined Modality Therapy; Conditioning, Classical; Extinction, Psychological; Heroin Dependence; Humans; Male; Methadone; Naloxone; Naltrexone; Opioid-Related Disorders; Recurrence; Relaxation Therapy

1984
Narcotic discrimination in pigeons: antagonism by naltrexone.
    European journal of pharmacology, 1984, Oct-01, Volume: 105, Issue:1-2

    Topics: Animals; Columbidae; Cyclazocine; Discrimination, Psychological; Dose-Response Relationship, Drug; Ethylketocyclazocine; Meperidine; Morphine; Naloxone; Naltrexone; Narcotics

1984
Effects of naloxone and naltrexone on the increased water intake and drinking duration in phenobarbitone-treated rats.
    Psychopharmacology, 1983, Volume: 79, Issue:1

    Topics: Animals; Drinking Behavior; Drug Synergism; Male; Naloxone; Naltrexone; Phenobarbital; Rats; Time Factors

1983
Antagonism of the behavioral effects of ethanol by naltrexone in BALB/c, C57BL/6, and DBA/2 mice.
    Psychopharmacology, 1983, Volume: 79, Issue:4

    Topics: Animals; Behavior, Animal; Brain Chemistry; Dose-Response Relationship, Drug; Ethanol; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred Strains; Naloxone; Naltrexone

1983
Predictors of favorable outcome following naltrexone treatment.
    NIDA research monograph, 1983, Volume: 43

    Topics: Employment; Humans; Morphine; Naloxone; Naltrexone; Opioid-Related Disorders; Time Factors

1983
Facilitation of hot-plate response learning by pre- and posttraining naltrexone administration.
    Psychopharmacology, 1983, Volume: 81, Issue:1

    Topics: Animals; Learning; Male; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Reaction Time

1983
Pharmacokinetic quantitation of naltrexone controlled release from a copolymer delivery system.
    Journal of pharmacokinetics and biopharmaceutics, 1983, Volume: 11, Issue:4

    Topics: Animals; Delayed-Action Preparations; Female; Haplorhini; Kinetics; Male; Naloxone; Naltrexone

1983
Effects of opiate antagonists on hormones and behavior of male and female rhesus monkeys.
    Archives of sexual behavior, 1984, Volume: 13, Issue:1

    Topics: Aggression; Animals; Castration; Female; Follicle Stimulating Hormone; Hydrocortisone; Luteinizing Hormone; Macaca mulatta; Male; Naloxone; Naltrexone; Sexual Behavior, Animal; Social Environment; Testosterone

1984
Modifications in food intake and energy metabolism in rats as a function of chronic naltrexone infusions.
    Pharmacology, biochemistry, and behavior, 1984, Volume: 20, Issue:6

    Topics: Adipose Tissue; Animals; Body Temperature; Body Weight; Carbon Dioxide; Drinking Behavior; Energy Metabolism; Feeding Behavior; Infusions, Parenteral; Male; Naloxone; Naltrexone; Oxygen Consumption; Rats; Rats, Inbred Strains

1984
Abstinence treatments for opiate addicts: therapeutic community or naltrexone?
    NIDA research monograph, 1984, Volume: 49

    Topics: Follow-Up Studies; Humans; Male; Naloxone; Naltrexone; Opioid-Related Disorders; Substance-Related Disorders; Therapeutic Community

1984
Five-year follow-up of opiate addicts with naltrexone and behavior therapy.
    NIDA research monograph, 1984, Volume: 49

    Topics: Adult; Behavior Therapy; Combined Modality Therapy; Follow-Up Studies; Heroin Dependence; Humans; Male; Naloxone; Naltrexone; Recurrence

1984
Naloxone and naltrexone block the gastrointestinal effects of TRH and MK-212.
    Proceedings of the Western Pharmacology Society, 1984, Volume: 27

    Topics: Animals; Digestive System; Male; Naloxone; Naltrexone; Pyrazines; Rabbits; Rats; Rats, Inbred Strains; Thyrotropin-Releasing Hormone

1984
[Opiate antagonists].
    Casopis lekaru ceskych, 1984, Oct-19, Volume: 123, Issue:42

    Topics: Endorphins; Humans; Nalorphine; Naloxone; Naltrexone; Narcotic Antagonists; Thyrotropin-Releasing Hormone

1984
Acute effects of naloxone and naltrexone, but lack of delayed effects, on exploratory behavior in the rat.
    Psychopharmacology, 1984, Volume: 84, Issue:3

    Topics: Animals; Exploratory Behavior; Male; Motor Activity; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Time Factors

1984
Physiologic and morphologic changes and incidence of neoplasms in mice and rats fed naltrexone HCl for 24 months.
    The Journal of clinical psychiatry, 1984, Volume: 45, Issue:9 Pt 2

    Topics: Administration, Oral; Animals; Behavior, Animal; Carcinogens; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Eating; Female; Growth; Lethal Dose 50; Male; Mice; Naloxone; Naltrexone; Neoplasms, Experimental; Rats; Rats, Inbred F344; Sex Factors; Species Specificity

1984
Bioequivalence, dose-proportionality, and pharmacokinetics of naltrexone after oral administration.
    The Journal of clinical psychiatry, 1984, Volume: 45, Issue:9 Pt 2

    Topics: Administration, Oral; Adult; Dosage Forms; Dose-Response Relationship, Drug; Half-Life; Humans; Kinetics; Male; Naloxone; Naltrexone; Nausea; Tablets; Therapeutic Equivalency

1984
Naltrexone: a clinical perspective.
    The Journal of clinical psychiatry, 1984, Volume: 45, Issue:9 Pt 2

    Topics: Adult; Alcohol Drinking; Ambulatory Care; Follow-Up Studies; Heroin Dependence; Hospitalization; Humans; Middle Aged; Naloxone; Naltrexone; Opioid-Related Disorders; Patient Dropouts; Social Support; Substance Withdrawal Syndrome

1984
Naltrexone induction: psychologic and pharmacologic strategies.
    The Journal of clinical psychiatry, 1984, Volume: 45, Issue:9 Pt 2

    Topics: Ambulatory Care; Behavior Therapy; Clonidine; Counseling; Drug Administration Schedule; Drug Therapy, Combination; Family Therapy; Hospitalization; Humans; Illicit Drugs; Injections, Intramuscular; Naloxone; Naltrexone; Opioid-Related Disorders; Patient Dropouts; Research Design

1984
Clinical experience with naltrexone in suburban opioid addicts.
    The Journal of clinical psychiatry, 1984, Volume: 45, Issue:9 Pt 2

    Topics: Adult; Ambulatory Care; Combined Modality Therapy; Female; Guanabenz; Heroin Dependence; Humans; Male; Naloxone; Naltrexone; Opioid-Related Disorders; Patient Dropouts; Psychotherapy; Suburban Population; Time Factors

1984
Naltrexone treatment for addicted health-care professionals: a collaborative private practice experience.
    The Journal of clinical psychiatry, 1984, Volume: 45, Issue:9 Pt 2

    Topics: Adult; Age Factors; Aged; Female; Health Occupations; Humans; Male; Middle Aged; Naloxone; Naltrexone; Opioid-Related Disorders; Outcome and Process Assessment, Health Care; Physician Impairment; Private Practice; Time Factors

1984
Naltrexone treatment in a jail work-release program.
    The Journal of clinical psychiatry, 1984, Volume: 45, Issue:9 Pt 2

    Topics: Adolescent; Adult; Ambulatory Care; Combined Modality Therapy; Female; Humans; Male; Middle Aged; Naloxone; Naltrexone; New York; Opioid-Related Disorders; Outcome and Process Assessment, Health Care; Prisoners; Psychological Tests; Psychotherapy

1984
Reproductive toxicity and teratology evaluations of naltrexone.
    The Journal of clinical psychiatry, 1984, Volume: 45, Issue:9 Pt 2

    Topics: Animals; Body Weight; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Estrus; Female; Fertility; Fetus; Humans; Male; Maternal-Fetal Exchange; Naloxone; Naltrexone; Pregnancy; Rabbits; Rats; Reproduction; Sex Factors; Sexual Behavior, Animal; Teratogens

1984
The index of choice: indications of methadone patients' selection of naltrexone treatment.
    The American journal of drug and alcohol abuse, 1984, Volume: 10, Issue:2

    Topics: Adult; Attitude; Humans; Internal-External Control; Male; Methadone; Motivation; Naloxone; Naltrexone; Opioid-Related Disorders; Patient Acceptance of Health Care; Prospective Studies; Self Concept; Social Environment

1984
Strategies to improve compliance with narcotic antagonists.
    The American journal of drug and alcohol abuse, 1984, Volume: 10, Issue:2

    Topics: Combined Modality Therapy; Humans; Life Style; Methadone; Naloxone; Naltrexone; Opioid-Related Disorders; Patient Compliance; Patient Dropouts; Research; Social Support; Substance Withdrawal Syndrome

1984
Naltrexone treatment of heroin addiction: one-year follow-up.
    Drug and alcohol dependence, 1984, Volume: 13, Issue:4

    Topics: Adult; Age Factors; Female; Follow-Up Studies; Heroin Dependence; Humans; Male; Methadyl Acetate; Motivation; Naloxone; Naltrexone

1984
Ventromedial and lateral hypothalamic injections of naloxone or naltrexone suppress the acute food intake of food-deprived rats.
    Appetite, 1984, Volume: 5, Issue:1

    Topics: Animals; Anorexia; Eating; Food Deprivation; Hypothalamic Area, Lateral; Injections; Male; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Ventromedial Hypothalamic Nucleus

1984
Kinetics of a naltrexone sustained-release preparation.
    Clinical pharmacology and therapeutics, 1984, Volume: 36, Issue:5

    Topics: Absorption; Adult; Biological Availability; Delayed-Action Preparations; Drug Implants; Gas Chromatography-Mass Spectrometry; Half-Life; Humans; Injections, Intravenous; Kinetics; Male; Naloxone; Naltrexone

1984
Naltrexone-reversible effects of flunitrazepam on locomotor activity and passive avoidance behaviour in mice.
    European journal of pharmacology, 1984, Sep-03, Volume: 104, Issue:1-2

    Topics: Animals; Avoidance Learning; Flunitrazepam; Male; Memory; Mice; Mice, Inbred C57BL; Motor Activity; Naloxone; Naltrexone

1984
Naloxone protein binding in adult and foetal plasma.
    European journal of clinical pharmacology, 1984, Volume: 27, Issue:4

    Topics: Adult; Blood Proteins; Female; Fetal Blood; Humans; Male; Naloxone; Naltrexone; Pregnancy; Protein Binding; Serum Albumin

1984
Nalmefene: radioimmunoassay for a new opioid antagonist.
    Journal of pharmaceutical sciences, 1984, Volume: 73, Issue:11

    Topics: Humans; Kinetics; Naloxone; Naltrexone; Narcotic Antagonists; Radioimmunoassay

1984
Methadone and naltrexone in the treatment of heroin dependence.
    The Psychiatric clinics of North America, 1984, Volume: 7, Issue:4

    Topics: Heroin Dependence; Humans; Methadone; Naloxone; Naltrexone; Psychotherapy; Substance Withdrawal Syndrome; Time Factors

1984
Effects of centrally administered naloxone on phrenic nerve activity.
    Brain research, 1984, Dec-24, Volume: 324, Issue:2

    Topics: Animals; Cats; Central Nervous System; Endorphins; Injections, Intravenous; Injections, Intraventricular; Naloxone; Naltrexone; Phrenic Nerve; Respiration

1984
Effects of naltrexone on plasma corticosterone in opiate-naive rats: a central action.
    Life sciences, 1984, Mar-19, Volume: 34, Issue:12

    Topics: Animals; Corticosterone; Dose-Response Relationship, Drug; Humans; Hypothalamo-Hypophyseal System; Male; Morphine Dependence; Naloxone; Naltrexone; Pituitary-Adrenal System; Rats; Rats, Inbred Strains

1984
A rapid, quantitative in vivo assay for narcotic antagonists.
    Substance and alcohol actions/misuse, 1984, Volume: 5, Issue:2

    Topics: Animals; Dose-Response Relationship, Drug; Female; Humans; Morphine Dependence; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Skin Temperature; Tail; Time Factors

1984
Do testicular opiates regulate Leydig cell function?
    Endocrinology, 1984, Volume: 115, Issue:4

    Topics: Androgen-Binding Protein; Animals; Chorionic Gonadotropin; Endorphins; Epididymis; Leydig Cells; Male; Naloxone; Naltrexone; Organ Size; Rats; Rats, Inbred Strains; Testosterone

1984
Endogenous opiates and stress. Behavioral activation elicited in the rat and effects of naltrexone, diprenorphine and morphine.
    Neuropharmacology, 1984, Volume: 23, Issue:12A

    Topics: Animals; Behavior, Animal; Diprenorphine; Endorphins; Humans; Male; Morphinans; Morphine; Naloxone; Naltrexone; Noise; Rats; Rats, Inbred Strains; Receptors, Drug; Stress, Psychological; Time Factors

1984
The behavioural depression of hippocampal kindled rats is attenuated by subcutaneous and intracerebroventricular naltrexone.
    Progress in neuro-psychopharmacology & biological psychiatry, 1984, Volume: 8, Issue:4-6

    Topics: Amygdala; Animals; Depression; Humans; Injections, Intraventricular; Injections, Subcutaneous; Kindling, Neurologic; Male; Naloxone; Naltrexone; Rats; Rats, Inbred Strains

1984
Opioid involvement in hypertension induced by short-term isolation.
    Clinical and experimental hypertension. Part A, Theory and practice, 1984, Volume: 6, Issue:10-11

    Topics: Adrenalectomy; Animals; Clonidine; Endorphins; Humans; Hypertension; Male; Naloxone; Naltrexone; Psychophysiologic Disorders; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Social Isolation

1984
The effects of intrathecal morphine and naltrexone on autotomy in sciatic nerve sectioned rats.
    Pain, 1984, Volume: 18, Issue:3

    Topics: Animals; Behavior, Animal; Differential Threshold; Disease Models, Animal; Injections, Spinal; Male; Morphine; Naloxone; Naltrexone; Nociceptors; Pain; Rats; Rats, Inbred Strains; Sciatic Nerve; Time Factors

1984
Endorphins in endotoxin-induced hyperglycemia in mice.
    Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement, 1983, Volume: 6

    Topics: Animals; Endorphins; Endotoxins; Hyperglycemia; Male; Mice; Mice, Inbred C3H; Morphine; Naloxone; Naltrexone; Quaternary Ammonium Compounds

1983
Neurohormonal modulation of natural resistance to a murine lymphoma.
    Journal of the National Cancer Institute, 1984, Volume: 72, Issue:3

    Topics: Animals; Corticosterone; Electroshock; Handling, Psychological; Hydrocortisone; Immunity, Innate; Lymphoma; Mice; Mice, Inbred DBA; Naloxone; Naltrexone

1984
Increased brain size and cellular content in infant rats treated with an opiate antagonist.
    Science (New York, N.Y.), 1983, Sep-16, Volume: 221, Issue:4616

    Topics: Animals; Animals, Newborn; Body Weight; Brain; Cerebellum; Morphine; Naloxone; Naltrexone; Neuroglia; Organ Size; Rats; Rats, Inbred Strains; Somatosensory Cortex

1983
Role of endorphins in endotoxin-induced hyperglycaemia in mice.
    Neuropharmacology, 1983, Volume: 22, Issue:9

    Topics: Animals; Blood Glucose; Drug Tolerance; Endorphins; Endotoxins; Hyperglycemia; Male; Mice; Mice, Inbred C3H; Morphine; Naloxone; Naltrexone

1983
Nalmefene decreases meal size, food and water intake and weight gain in Zucker rats.
    Pharmacology, biochemistry, and behavior, 1983, Volume: 19, Issue:2

    Topics: Animals; Appetite; Appetite Depressants; Body Weight; Drinking; Energy Intake; Female; Male; Naloxone; Naltrexone; Obesity; Rats; Rats, Zucker; Time Factors

1983
Opiate antagonists, morphine and spatial memory in rats.
    Pharmacology, biochemistry, and behavior, 1983, Volume: 19, Issue:3

    Topics: Animals; Dose-Response Relationship, Drug; Endorphins; Male; Memory; Morphine; Naloxone; Naltrexone; Rats; Retention, Psychology

1983
Patterns of drinking in the rat following the administration of opiate antagonists.
    Pharmacology, biochemistry, and behavior, 1983, Volume: 19, Issue:3

    Topics: Animals; Depression, Chemical; Diprenorphine; Drinking Behavior; Male; Morphinans; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Water Deprivation

1983
Naltrexone and clonidine: alternatives to methadone.
    American family physician, 1983, Volume: 28, Issue:5

    Topics: Clonidine; Humans; Naloxone; Naltrexone; Opioid-Related Disorders

1983
Interaction of the opiate antagonist, naltrexone methyl bromide, with the acetylcholine receptor system of the motor end-plate.
    Brain research, 1983, Oct-31, Volume: 277, Issue:2

    Topics: Animals; Female; Membrane Potentials; Motor Endplate; Naloxone; Naltrexone; Neuromuscular Junction; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Receptors, Cholinergic

1983
Opioid antagonists inhibit the growth of metastatic murine neuroblastoma.
    Cancer letters, 1983, Volume: 21, Issue:1

    Topics: Animals; Cell Line; Male; Mice; Naloxone; Naltrexone; Neoplasm Transplantation; Neuroblastoma; Probability; Time Factors

1983
Morphine antagonizes pentobarbital-induced anesthesia.
    Neuropharmacology, 1983, Volume: 22, Issue:10

    Topics: Anesthesia; Animals; Atropine; Behavior, Animal; Electroencephalography; Male; Morphine; Naloxone; Naltrexone; Pentobarbital; Rabbits; Seizures

1983
Predictors of favorable outcome following naltrexone treatment.
    Drug and alcohol dependence, 1983, Volume: 12, Issue:2

    Topics: Employment; Follow-Up Studies; Humans; Male; Marriage; Naloxone; Naltrexone; Opioid-Related Disorders; Patient Acceptance of Health Care; Regression Analysis; Social Support; Time Factors

1983
Inhibition of morphine-induced analgesia and locomotor activity in strains of mice: a comparison of long-acting opiate antagonists.
    Pharmacology, biochemistry, and behavior, 1983, Volume: 19, Issue:6

    Topics: Animals; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Morphine; Motor Activity; Naloxone; Naltrexone; Pain; Species Specificity

1983
Nalmefene: quantitation of a new narcotic antagonist in human plasma using high performance-liquid chromatography with electrochemical detection.
    Research communications in chemical pathology and pharmacology, 1983, Volume: 42, Issue:3

    Topics: Chromatography, High Pressure Liquid; Electrochemistry; Humans; Kinetics; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Time Factors

1983
Determination of naloxone in blood by high-performance liquid chromatography.
    Journal of chromatography, 1983, Dec-09, Volume: 278, Issue:2

    Topics: Chromatography, High Pressure Liquid; Humans; Hydrogen-Ion Concentration; Infant, Newborn; Infant, Premature; Naloxone; Naltrexone

1983
Discriminative stimulus effects of naltrexone in narcotic-naive and morphine-treated pigeons.
    The Journal of pharmacology and experimental therapeutics, 1983, Volume: 224, Issue:2

    Topics: Animals; Columbidae; Conditioning, Operant; Discrimination Learning; Dose-Response Relationship, Drug; Humans; Morphine Dependence; Naloxone; Naltrexone

1983
Prolonged excretion of morphine in rats during protracted abstinence: lack of effect of naltrexone.
    The Journal of pharmacology and experimental therapeutics, 1983, Volume: 224, Issue:2

    Topics: Animals; Body Weight; Gas Chromatography-Mass Spectrometry; Humans; Male; Morphine; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome

1983
A preliminary description of acute physical dependence on morphine in the vervet monkey.
    Pharmacology, biochemistry, and behavior, 1983, Volume: 18, Issue:2

    Topics: Animals; Behavior, Animal; Catheterization; Chlorocebus aethiops; Humans; Male; Morphine; Morphine Dependence; Naloxone; Naltrexone; Substance Withdrawal Syndrome

1983
Reversal of morphine-induced catalepsy in the rat by narcotic antagonists and their quaternary derivatives.
    Neuropharmacology, 1983, Volume: 22, Issue:3

    Topics: Animals; Catalepsy; Humans; Injections, Intraventricular; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains

1983
Use of the novel irreversible opiate antagonist, beta-chlornaltrexamine, in the estimation of the normorphine affinity constant in naive and morphine tolerant guinea-pig ilea.
    Proceedings of the Western Pharmacology Society, 1983, Volume: 26

    Topics: Animals; Female; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Morphine Dependence; Morphine Derivatives; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists

1983
Spinal antagonism of tolerance and dependence induced by systemically administered morphine.
    European journal of pharmacology, 1983, Oct-14, Volume: 94, Issue:1-2

    Topics: Animals; Drug Tolerance; Humans; Male; Morphine; Morphine Dependence; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Reaction Time; Spinal Cord

1983
Effect of naltrexone on food intake and hoarding in white-footed mice (Peromyscus).
    Pharmacology, biochemistry, and behavior, 1984, Volume: 20, Issue:1

    Topics: Animals; Eating; Feeding Behavior; Female; Injections, Intraperitoneal; Male; Naloxone; Naltrexone; Peromyscus

1984
Opiate antagonists reverse the hypoactivity associated with systemic anaphylaxis in mice.
    Pharmacology, biochemistry, and behavior, 1984, Volume: 20, Issue:3

    Topics: Anaphylaxis; Animals; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists

1984
Effects of opiate antagonists and their quaternary derivatives on heroin self-administration in the rat.
    The Journal of pharmacology and experimental therapeutics, 1984, Volume: 229, Issue:2

    Topics: Animals; Dose-Response Relationship, Drug; Heroin; Male; Naloxone; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Reinforcement, Psychology; Self Administration; Time Factors

1984
Pharmacological profile of wet-dog shaking induced by electrical stimulation of the fornix in rats.
    Pharmacological research communications, 1984, Volume: 16, Issue:3

    Topics: Adenosine; Aminooxyacetic Acid; Animals; Atropine; Behavior, Animal; Dopamine; Electric Stimulation; Electrodes, Implanted; Female; gamma-Aminobutyric Acid; Injections, Intraventricular; Limbic System; Naloxone; Naltrexone; Neural Pathways; Physostigmine; Picrotoxin; Propranolol; Rats; Rats, Inbred Strains; Serotonin

1984
Naloxone improves, and morphine exacerbates, experimental shock induced by release of endogenous histamine by compound 48/80.
    Brain research, 1984, Apr-09, Volume: 297, Issue:1

    Topics: Animals; Central Nervous System; Endorphins; Histamine; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Naltrexone; p-Methoxy-N-methylphenethylamine; Shock

1984
Electrochemical chromatographic determinations of morphine antagonists in biological fluids, with applications.
    Journal of pharmaceutical sciences, 1984, Volume: 73, Issue:5

    Topics: Animals; Chromatography, High Pressure Liquid; Dogs; Electrochemistry; Erythrocytes; Humans; In Vitro Techniques; Morphine; Naloxone; Naltrexone; Protein Binding; Ultracentrifugation

1984
Naltrexone effects on pituitary neurointermediate lobe and median eminence.
    Neurochemical research, 1984, Volume: 9, Issue:2

    Topics: Animals; Axons; Cytoplasm; Dose-Response Relationship, Drug; Ependyma; Male; Median Eminence; Microscopy, Electron; Naloxone; Naltrexone; Norepinephrine; Pituitary Gland, Posterior; Rats; Rats, Inbred Strains

1984
Effects of naloxone and naltrexone on drug-induced hypothermia in mice.
    Neuropharmacology, 1984, Volume: 23, Issue:5

    Topics: Animals; Apomorphine; Body Temperature; Body Temperature Regulation; Dopamine; Haloperidol; Male; Mice; Mice, Inbred Strains; Naloxone; Naltrexone; Narcotics; Pentobarbital

1984
Ethanol inhibits the naloxone-induced release of luteinizing hormone-releasing hormone from the hypothalamus of the male rat.
    Life sciences, 1982, Oct-11, Volume: 31, Issue:15

    Topics: Animals; Cell Membrane; Dose-Response Relationship, Drug; Drug Antagonism; Ethanol; Gonadotropin-Releasing Hormone; Hypothalamus; Luteinizing Hormone; Male; Naloxone; Naltrexone; Pituitary Gland; Rats; Rats, Inbred Strains

1982
Alteration of ethanol self-administration by naltrexone.
    Life sciences, 1980, Mar-03, Volume: 26, Issue:9

    Topics: Animals; Dose-Response Relationship, Drug; Ethanol; Haplorhini; Macaca mulatta; Male; Naloxone; Naltrexone; Reinforcement, Psychology; Self Administration

1980
Clonidine hydrochloride detoxification from methadone treatments: the value of naltrexone aftercare.
    NIDA research monograph, 1981, Volume: 34

    Topics: Adolescent; Clonidine; Humans; Inactivation, Metabolic; Methadone; Naloxone; Naltrexone; Opium; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors

1981
Psychotherapy and naltrexone in opioid dependence.
    NIDA research monograph, 1981, Volume: 34

    Topics: Adult; Humans; Naloxone; Naltrexone; Opioid-Related Disorders; Opium; Psychotherapy; Time Factors

1981
Narcotic antagonists: naltrexone pharmacochemistry and sustained-release preparations.
    NIDA research monograph, 1981, Volume: 28

    Topics: Animals; Chemistry, Pharmaceutical; Delayed-Action Preparations; Humans; Naloxone; Naltrexone; Narcotic Antagonists

1981
The metabolism of naltrexone in man.
    NIDA research monograph, 1981, Volume: 28

    Topics: Administration, Oral; Biotransformation; Erythrocytes; Feces; Humans; Injections, Intravenous; Injections, Subcutaneous; Naloxone; Naltrexone

1981
The clinical pharmacology of naltrexone: pharmacology and pharmacodynamics.
    NIDA research monograph, 1981, Volume: 28

    Topics: Animals; Biotransformation; Feces; Humans; Naloxone; Naltrexone; Opioid-Related Disorders; Time Factors; Tissue Distribution

1981
Overview of human pharmacokinetics of naltrexone.
    NIDA research monograph, 1981, Volume: 28

    Topics: Humans; Kinetics; Male; Naloxone; Naltrexone

1981
Pharmacokinetic quantitation of naltrexone release from several sustained-release delivery systems.
    NIDA research monograph, 1981, Volume: 28

    Topics: Animals; Chemistry, Pharmaceutical; Delayed-Action Preparations; Haplorhini; Humans; Injections; Injections, Subcutaneous; Kinetics; Naloxone; Naltrexone

1981
An electron-capture gas chromatographic assay for naltrexone in biological fluids.
    NIDA research monograph, 1981, Volume: 28

    Topics: Chromatography, Gas; Humans; Naloxone; Naltrexone

1981
Solid solutions as long-acting naltrexone delivery systems.
    NIDA research monograph, 1981, Volume: 28

    Topics: Analgesics; Animals; Chemistry, Pharmaceutical; Drug Implants; Naloxone; Naltrexone; Rats; Solubility

1981
Historical perspective on the chemistry and development of naltrexone.
    NIDA research monograph, 1981, Volume: 28

    Topics: Animals; Benzomorphans; Heroin Dependence; History, 20th Century; Humans; Morphine; Naloxone; Naltrexone; Narcotic Antagonists

1981
Quantitative determination of naltrexone, 6 beta-naltrexol and 2-hydroxy-3-methoxy-6 beta-naltrexol (HMN) in human plasma, red blood cells, saliva and urine by gas liquid chromatography.
    NIDA research monograph, 1981, Volume: 28

    Topics: Biotransformation; Chromatography, Gas; Erythrocytes; Humans; Hydrolysis; Naloxone; Naltrexone; Saliva

1981
Analytical methods for quantitative and qualitative analysis of naltrexone and metabolites in biological fluids.
    NIDA research monograph, 1981, Volume: 28

    Topics: Body Fluids; Chromatography, Thin Layer; Gas Chromatography-Mass Spectrometry; Humans; Naloxone; Naltrexone

1981
A comparative study of the oral, intravenous, and subcutaneous administration of 3H-naltrexone to normal male volunteers.
    NIDA research monograph, 1981, Volume: 28

    Topics: Administration, Oral; Feces; Humans; Injections, Intravenous; Injections, Subcutaneous; Male; Naloxone; Naltrexone; Time Factors

1981
Threshold differences for naloxone and naltrexone in the hypothalamus and midbrain using fixed ratio brain self-stimulation in rats.
    Psychopharmacology, 1981, Volume: 74, Issue:1

    Topics: Animals; Brain; Dose-Response Relationship, Drug; Electrodes, Implanted; Hypothalamus; Male; Mesencephalon; Morphine; Naloxone; Naltrexone; Rats; Reinforcement Schedule; Self Stimulation

1981
Effects of selected opioid agonists and antagonists on DMT- and LSD-25-induced disruption of food-rewarded bar pressing behavior in the rat.
    Psychopharmacology, 1981, Volume: 75, Issue:3

    Topics: Animals; Conditioning, Operant; Drug Interactions; Drug Synergism; Lysergic Acid Diethylamide; Male; Methadone; Morphine; N,N-Dimethyltryptamine; Naloxone; Naltrexone; Narcotics; Rats; Reinforcement, Psychology; Tryptamines

1981
Naltrexone and psychotherapy.
    NIDA research monograph, 1982, Volume: 41

    Topics: Heroin Dependence; Humans; Naloxone; Naltrexone; Psychotherapy

1982
Cardiovascular effects of naloxone, naltrexone and morphine in the squirrel monkey.
    Life sciences, 1983, Jan-24, Volume: 32, Issue:4

    Topics: Animals; Blood Pressure; Dose-Response Relationship, Drug; Heart Rate; Male; Morphine; Naloxone; Naltrexone; Saimiri

1983
Stereospecific enhancement of evoked release of brain acetylcholine by narcotic antagonists.
    British journal of pharmacology, 1983, Volume: 78, Issue:2

    Topics: Acetylcholine; Animals; Brain; Electric Stimulation; Enkephalins; Hypophysectomy; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Stereoisomerism

1983
Attenuation of alcohol drinking in tetrahydroisoquinoline-treated rats by morphine and naltrexone.
    Pharmacology, biochemistry, and behavior, 1983, Volume: 18, Issue:2

    Topics: Alcohol Drinking; Animals; Body Weight; Drinking Behavior; Feeding Behavior; Isoquinolines; Male; Morphine; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Tetrahydroisoquinolines

1983
Effects of naloxone and its quarternary analogue on stimulation-induced feeding.
    Neuropharmacology, 1983, Volume: 22, Issue:1

    Topics: Animals; Electric Stimulation; Feeding Behavior; Hypothalamus; Male; Naloxone; Naltrexone; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains

1983
Effects of opiate agonists and antagonists on fluid intake and saccharin choice in the rat.
    Neuropharmacology, 1983, Volume: 22, Issue:3

    Topics: Animals; Choice Behavior; Drinking Behavior; Enkephalins; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Saccharin

1983
Effects of chronic antenatal and postnatal administration of narcotics on naloxone-induced anorexia in preweanling rats.
    Neuropharmacology, 1983, Volume: 22, Issue:3

    Topics: Aging; Animals; Animals, Suckling; Body Weight; Drug Interactions; Feeding Behavior; Female; Motor Activity; Naloxone; Naltrexone; Narcotics; Pregnancy; Prenatal Exposure Delayed Effects; Rats

1983
Naltrexone modulates tumor response in mice with neuroblastoma.
    Science (New York, N.Y.), 1983, Aug-12, Volume: 221, Issue:4611

    Topics: Animals; Dose-Response Relationship, Drug; Endorphins; Male; Mice; Mice, Inbred Strains; Naloxone; Naltrexone; Neoplasm Transplantation; Neoplasms, Experimental; Neuroblastoma

1983
Naltrexone effects on plasma vasopressin concentration elevated and lowered by various stimuli.
    The Journal of pharmacology and experimental therapeutics, 1983, Volume: 226, Issue:2

    Topics: Animals; Arginine Vasopressin; Blood Pressure; Hematocrit; Male; Naloxone; Naltrexone; Nicotine; Rats; Rats, Inbred Strains; Sodium; Stress, Physiological; Water-Electrolyte Balance

1983
Effects of opiate antagonists on social and aggressive behavior of isolated mice.
    Pharmacology, biochemistry, and behavior, 1982, Volume: 17, Issue:4

    Topics: Aggression; Analysis of Variance; Animals; Humans; Male; Mice; Mice, Inbred DBA; Naloxone; Naltrexone; Social Behavior; Social Isolation

1982
Classification of narcotics on the basis of their reinforcing, discriminative, and antagonist effects in rhesus monkeys.
    Federation proceedings, 1982, Volume: 41, Issue:2

    Topics: Animals; Behavior, Animal; Conditioning, Operant; Cyclazocine; Discrimination, Psychological; Ethylketocyclazocine; Humans; Macaca; Macaca mulatta; Morphine; Naloxone; Naltrexone; Narcotics; Opioid-Related Disorders; Reinforcement, Psychology; Self Administration

1982
Drinking, but not feeding, is opiate-sensitive in hamsters.
    Life sciences, 1982, May-10, Volume: 30, Issue:19

    Topics: Animals; Anorexia; Cricetinae; Deoxyglucose; Dexamethasone; Drinking; Eating; Feeding Behavior; Food Deprivation; Insulin; Male; Mesocricetus; Naloxone; Naltrexone; Rats; Rats, Inbred Strains

1982
Opiate antagonists stimulate ruminal motility of conscious goats.
    European journal of pharmacology, 1982, Jan-08, Volume: 77, Issue:1

    Topics: Animals; Female; Goats; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists; Rumen

1982
Effect of endogenous opioid blockade on the amplitude and frequency of pulsatile luteinizing hormone secretion in normal men.
    The Journal of clinical endocrinology and metabolism, 1982, Volume: 54, Issue:4

    Topics: Adult; Endorphins; Humans; Luteinizing Hormone; Male; Naloxone; Naltrexone

1982
Opiates and thermoregulation in mice. II. Effects of opiate antagonists.
    The Journal of pharmacology and experimental therapeutics, 1982, Volume: 220, Issue:3

    Topics: Animals; Body Temperature Regulation; Dose-Response Relationship, Drug; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Time Factors

1982
Opiate modification of amygdaloid-kindled seizures in rats.
    Pharmacology, biochemistry, and behavior, 1982, Volume: 16, Issue:5

    Topics: Amygdala; Animals; Electroencephalography; Kindling, Neurologic; Male; Morphine; Naloxone; Naltrexone; Narcotics; Rats; Rats, Inbred Strains

1982
Narcotic antagonistic potency of bivalent ligands which contain beta-naltrexamine. Evidence for bridging between proximal recognition sites.
    Journal of medicinal chemistry, 1982, Volume: 25, Issue:7

    Topics: Animals; Chemical Phenomena; Chemistry; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Ligands; Male; Mice; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists

1982
Quaternary narcotic antagonists' relative ability to prevent antinociception and gastrointestinal transit inhibition in morphine-treated rats as an index of peripheral selectivity.
    Life sciences, 1982, May-31, Volume: 30, Issue:22

    Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Gastrointestinal Motility; Male; Morphine; Nalorphine; Naloxone; Naltrexone; Pain; Rats; Structure-Activity Relationship

1982
Effects of yohimbine and naltrexone in counteraction of the morphine Straub tail and the amphetamine-potentiated morphine Straub tail in mice.
    Life sciences, 1982, Jun-14, Volume: 30, Issue:24

    Topics: Amphetamine; Animals; Male; Mice; Morphine; Naloxone; Naltrexone; Phentolamine; Tail; Yohimbine

1982
A comparison of the effects of opiate antagonists on operant and ingestive behavior.
    Pharmacology, biochemistry, and behavior, 1982, Volume: 16, Issue:6

    Topics: Animals; Conditioning, Operant; Dose-Response Relationship, Drug; Drinking; Eating; Male; Naloxone; Naltrexone; Rats; Rats, Inbred Strains

1982
The effects of chronic administration of naltrexone on appetite and water exchange in rats.
    Pharmacology, biochemistry, and behavior, 1982, Volume: 16, Issue:6

    Topics: Animals; Appetite; Drinking; Eating; Kidney Concentrating Ability; Male; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Water-Electrolyte Balance

1982
Development of tolerance to the effects of morphine on luteinizing hormone secretion as a function of castration in the male rat.
    The Journal of pharmacology and experimental therapeutics, 1982, Volume: 223, Issue:3

    Topics: Analgesics; Animals; Brain; Castration; Dose-Response Relationship, Drug; Drug Tolerance; Luteinizing Hormone; Male; Morphine; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Testosterone

1982
Effects of opiate antagonists and of morphine on chlordiazepoxide-induced hyperdipsia in the water-deprived rat.
    Neuropharmacology, 1982, Volume: 21, Issue:10

    Topics: Analysis of Variance; Animals; Chlordiazepoxide; Drinking; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Thirst; Water Deprivation

1982
Analysis of the interaction of naltrexone with eating following adrenergic and cholinergic stimulation of the hypothalamus.
    Neuropharmacology, 1982, Volume: 21, Issue:9

    Topics: Animals; Carbachol; Dose-Response Relationship, Drug; Feeding Behavior; Hypothalamus; Male; Naloxone; Naltrexone; Norepinephrine; Rats; Rats, Inbred Strains

1982
Data acquisition system used in studying naltrexone and behavior of primates.
    Biomedical sciences instrumentation, 1982, Volume: 18

    Topics: Animals; Computers; Data Collection; Female; Macaca radiata; Methods; Motor Activity; Naloxone; Naltrexone; Social Behavior

1982
Potentiation by naltrexone of d-amphetamine-induced behavioral suppression and its reversal by clonidine.
    Life sciences, 1982, Dec-20, Volume: 31, Issue:25

    Topics: Animals; Clonidine; Conditioning, Operant; Dextroamphetamine; Drug Interactions; Male; Naloxone; Naltrexone; Pimozide; Rats; Rats, Inbred Strains; Receptors, Dopamine

1982
Palatability-induced drinking after administration of morphine, naltrexone and diazepam in the non-deprived rat.
    Substance and alcohol actions/misuse, 1982, Volume: 3, Issue:5

    Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Drinking; Male; Morphine; Muridae; Naloxone; Naltrexone; Taste

1982
Chronic administration of naltrexone alters central catecholamine levels but not the development of hypertension in spontaneously hypertensive rats.
    Neuropharmacology, 1982, Volume: 21, Issue:11

    Topics: Animals; Blood Pressure; Brain Chemistry; Catecholamines; Heart Rate; Hypertension; Male; Naloxone; Naltrexone; Norepinephrine; Rats; Rats, Inbred Strains; Time Factors

1982
Narcotic antagonist potentiation of L-DOPA in the reversal of reserpine induced catalepsy.
    Proceedings of the Western Pharmacology Society, 1980, Volume: 23

    Topics: Animals; Catalepsy; Drug Synergism; Humans; Levodopa; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Reserpine; Time Factors

1980
Naloxone overcomes the dopaminergic, EEG, and behavioral effects of gamma-hydroxybutyrate.
    Neurology, 1980, Volume: 30, Issue:8

    Topics: 4-Butyrolactone; Animals; Behavior, Animal; Catalepsy; Corpus Striatum; Dopamine; Electroencephalography; Epinephrine; Furans; Humans; Male; Naloxone; Naltrexone; Rats

1980
Behavioural and endocrine effects of naltrexone in male talapoin monkeys.
    Pharmacology, biochemistry, and behavior, 1980, Volume: 13, Issue:5

    Topics: Aggression; Animals; Cercopithecidae; Hormones; Humans; Male; Naloxone; Naltrexone; Sexual Behavior, Animal; Social Behavior

1980
The relationship between the acute behavioral effects of narcotic antagonists and the narcotic-dependent state [proceedings].
    Psychopharmacology bulletin, 1981, Volume: 17, Issue:1

    Topics: Animals; Behavior, Animal; Columbidae; Cyclazocine; Humans; Morphine Dependence; Naloxone; Naltrexone; Narcotic Antagonists

1981
Effects of narcotic antagonists on L-dopa reversal of reserpine-induced catalepsy and blepharoptosis in mice.
    Life sciences, 1981, Apr-06, Volume: 28, Issue:14

    Topics: Animals; Blepharoptosis; Catalepsy; Drug Antagonism; Drug Synergism; Humans; Kinetics; Levodopa; Male; Mice; Naloxone; Naltrexone; Reserpine

1981
Naltrexone effects on morphine and food self-administration in morphine-dependent rhesus monkeys.
    The Journal of pharmacology and experimental therapeutics, 1981, Volume: 218, Issue:2

    Topics: Animals; Conditioning, Operant; Food; Humans; Macaca mulatta; Male; Morphine; Morphine Dependence; Naloxone; Naltrexone; Self Administration; Substance Withdrawal Syndrome

1981
Antagonism of gut, but not central effects of morphine with quaternary narcotic antagonists.
    European journal of pharmacology, 1982, Mar-12, Volume: 78, Issue:3

    Topics: Animals; Central Nervous System; Diarrhea; Digestive System; Dogs; Female; Humans; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Rats; Rats, Inbred Strains; Species Specificity; Substance Withdrawal Syndrome

1982
Tetrahydroisoquinoline and opioid substrates of alcohol actions.
    Progress in clinical and biological research, 1982, Volume: 90

    Topics: Alcoholism; Animals; Disease Models, Animal; Ethanol; Humans; Isoquinolines; Macaca mulatta; Male; Naloxone; Naltrexone; Narcotics; Rats; Rats, Inbred Strains; Self Administration; Tetrahydroisoquinolines

1982
Lack of effect of choline and narcotic antagonists upon apomorphine discrimination.
    European journal of pharmacology, 1980, Nov-21, Volume: 68, Issue:2

    Topics: Animals; Apomorphine; Choline; Discrimination Learning; Haloperidol; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Receptors, Dopamine

1980
Reduced behavioral activity due to opiate blockade: relations to stress.
    The International journal of neuroscience, 1981, Volume: 12, Issue:1

    Topics: Animals; Endorphins; Male; Motor Activity; Naloxone; Naltrexone; Rats; Stress, Physiological; Time Factors

1981
Acute and chronic effects of naltrexone and naloxone on schedule-controlled behavior of squirrel monkeys and pigeons.
    The Journal of pharmacology and experimental therapeutics, 1981, Volume: 216, Issue:3

    Topics: Animals; Behavior, Animal; Columbidae; Conditioning, Psychological; Dose-Response Relationship, Drug; Food; Male; Morphine; Naloxone; Naltrexone; Saimiri; Time Factors

1981
Effects of naltrexone dose and history of naltrexone exposure on food- and codeine-maintained responding in rhesus monkeys.
    The Journal of pharmacology and experimental therapeutics, 1981, Volume: 217, Issue:1

    Topics: Animals; Codeine; Conditioning, Operant; Dose-Response Relationship, Drug; Food; Macaca mulatta; Naloxone; Naltrexone; Reaction Time

1981
Suppression of drinking by naloxone in the rat: a further characterization.
    European journal of pharmacology, 1981, Jan-29, Volume: 69, Issue:3

    Topics: Angiotensin II; Animals; Depression, Chemical; Drinking; Isoproterenol; Male; Naloxone; Naltrexone; Rats; Reinforcement Schedule

1981
Opiate regulation of angiotensin-induced drinking and vasopressin release.
    The Journal of pharmacology and experimental therapeutics, 1981, Volume: 217, Issue:3

    Topics: Angiotensin II; Animals; Drinking; Endorphins; Enkephalin, Leucine; Enkephalins; Male; Naloxone; Naltrexone; Rats; Saralasin; Vasopressins

1981
Narcotic antagonists attenuate drinking induced by water deprivation in a primate.
    Life sciences, 1981, Mar-16, Volume: 28, Issue:11

    Topics: Animals; Diprenorphine; Dose-Response Relationship, Drug; Drinking Behavior; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Saimiri; Water Deprivation

1981
Supersensitivity to the behavioral effects of opiate antagonists [proceedings].
    Psychopharmacology bulletin, 1981, Volume: 17, Issue:1

    Topics: Animals; Behavior, Animal; Guinea Pigs; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Saimiri

1981
Enhancement of apomorphine-induced climbing in mice by reversible and irreversible narcotic antagonist drugs.
    Life sciences, 1981, Mar-23, Volume: 28, Issue:12

    Topics: Animals; Apomorphine; Behavior, Animal; Drug Synergism; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Nitrogen Mustard Compounds; Time Factors

1981
Naltrexone-induced LH release in ovariectomized estrogen-primed rats.
    Endocrinologia japonica, 1981, Volume: 28, Issue:1

    Topics: Afferent Pathways; Animals; Castration; Dose-Response Relationship, Drug; Estrogens; Female; Hypothalamus; Luteinizing Hormone; Naloxone; Naltrexone; Rats

1981
Opiate antagonists: central sites of action in suppressing water intake of the rat.
    Brain research, 1981, Sep-28, Volume: 221, Issue:2

    Topics: Animals; Dose-Response Relationship, Drug; Drinking Behavior; Male; Naloxone; Naltrexone; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains

1981
The anorexic effect of naltrexone is independent of its suppressant effect on water intake.
    Neuropharmacology, 1981, Volume: 20, Issue:9

    Topics: Animals; Appetite Depressants; Drinking; Food Deprivation; Male; Naloxone; Naltrexone; Rats; Water Deprivation

1981
Suppression of drinking by naloxone in rats homo- and heterozygous for diabetes insipidus.
    Pharmacology, biochemistry, and behavior, 1981, Volume: 15, Issue:1

    Topics: Animals; Diabetes Insipidus; Drinking Behavior; Heterozygote; Homozygote; Male; Morphine; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Time Factors

1981
Naltrexone suppresses hyperphagia induced in the rat by a highly palatable diet.
    Pharmacology, biochemistry, and behavior, 1981, Volume: 15, Issue:1

    Topics: Animals; Benzamides; DEET; Feeding Behavior; Male; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Taste

1981
Blockade by naltrexone of analgesia produced by stimulation of the dorsal raphe nucleus.
    Pharmacology, biochemistry, and behavior, 1981, Volume: 15, Issue:3

    Topics: Analgesia; Animals; Brain Stem; Dose-Response Relationship, Drug; Electric Stimulation; Male; Naloxone; Naltrexone; Raphe Nuclei; Rats; Rats, Inbred Strains

1981
Effects of chronic administration of naltrexone on appetitive behaviors of rats.
    Progress in clinical and biological research, 1981, Volume: 68

    Topics: Analgesia; Animals; Appetitive Behavior; Body Weight; Drinking Behavior; Food Deprivation; Kinetics; Naloxone; Naltrexone; Rats; Rats, Inbred Strains

1981
Naltrexone and the tail flick reflex.
    Pharmacology, biochemistry, and behavior, 1981, Volume: 15, Issue:5

    Topics: Analgesics; Animals; Drug Interactions; Drug Tolerance; Male; Morphine; Naloxone; Naltrexone; Nociceptors; Rats; Rats, Inbred Strains; Reflex

1981
Multiple family therapy and naltrexone in the treatment of opiate dependence.
    Drug and alcohol dependence, 1981, Volume: 8, Issue:2

    Topics: Adolescent; Adult; Data Collection; Family Therapy; Female; Humans; Male; Middle Aged; Naloxone; Naltrexone; Narcotics; Retrospective Studies; Statistics as Topic; Substance-Related Disorders

1981
Naltrexone effects on food-and codeine-maintained responding in rhesus monkeys.
    European journal of pharmacology, 1981, Jul-17, Volume: 73, Issue:1

    Topics: Animals; Behavior, Animal; Codeine; Conditioning, Operant; Dose-Response Relationship, Drug; Food; Macaca mulatta; Naloxone; Naltrexone; Reinforcement, Psychology; Self Administration

1981
Naltrexone partially inhibits the estrogen-induced increase in prolactin secretion and anterior pituitary weight.
    Life sciences, 1981, Dec-28, Volume: 29, Issue:26

    Topics: Animals; Castration; Estradiol; Female; Male; Naloxone; Naltrexone; Pituitary Gland, Anterior; Prolactin; Rats; Rats, Inbred Strains

1981
Naltrexone: a short-term treatment for opiate dependence.
    The American journal of drug and alcohol abuse, 1981, Volume: 8, Issue:3

    Topics: Adult; Employment; Female; Humans; Male; Middle Aged; Naloxone; Naltrexone; Opioid-Related Disorders; Outcome and Process Assessment, Health Care; Patient Dropouts; Substance Withdrawal Syndrome; Time Factors

1981
The naloxone test for opiate dependence.
    Clinical pharmacology and therapeutics, 1980, Volume: 27, Issue:4

    Topics: Humans; Injections, Intramuscular; Injections, Intravenous; Methadyl Acetate; Naloxone; Naltrexone; Narcotics; Opioid-Related Disorders; Substance Withdrawal Syndrome

1980
The seminal excretion, plasma elimination, tissue distribution and metabolism of naltrexone in the rabbit.
    The Journal of pharmacology and experimental therapeutics, 1980, Volume: 213, Issue:2

    Topics: Animals; Biotransformation; Countercurrent Distribution; Gas Chromatography-Mass Spectrometry; Half-Life; Injections, Intravenous; Kinetics; Male; Naloxone; Naltrexone; Rabbits; Semen; Tissue Distribution

1980
Effects of heroin and naltrexone on plasma prolactin levels in man.
    Pharmacology, biochemistry, and behavior, 1980, Volume: 12, Issue:1

    Topics: Adult; Heroin; Heroin Dependence; Humans; Male; Naloxone; Naltrexone; Prolactin

1980
Self-administration of D-Ala2-Met-enkephalinamide at hypothalamic self-stimulation sites.
    Brain research, 1980, Jul-21, Volume: 194, Issue:1

    Topics: Animals; Dextrorphan; Dose-Response Relationship, Drug; Electric Stimulation; Endorphins; Enkephalins; Hypothalamus; Levallorphan; Levorphanol; Male; Morphine; Naloxone; Naltrexone; Rats; Self Stimulation

1980
Naltrexone influence on hibernation.
    Experientia, 1980, May-15, Volume: 36, Issue:5

    Topics: Acclimatization; Animals; Hibernation; Naloxone; Naltrexone; Rodentia; Sleep

1980
Heroin and naltrexone effects on pituitary-gonadal hormones in man: interaction of steroid feedback effects, tolerance and supersensitivity.
    The Journal of pharmacology and experimental therapeutics, 1980, Volume: 214, Issue:3

    Topics: Adult; Drug Tolerance; Feedback; Heroin Dependence; Humans; Luteinizing Hormone; Male; Naloxone; Naltrexone; Testosterone; Time Factors

1980
Interactions between naltrexone and non-opiate drugs evaluated by schedule-controlled behavior.
    Neuropharmacology, 1980, Volume: 19, Issue:11

    Topics: Animals; Conditioning, Operant; Dopamine; Drug Interactions; Ethanol; Male; Naloxone; Naltrexone; Rats; Reinforcement Schedule

1980
The treatment of heroin addiction: naltrexone alone and with behavior therapy.
    The International journal of the addictions, 1980, Volume: 15, Issue:6

    Topics: Adult; Behavior Therapy; Extinction, Psychological; Heroin Dependence; Humans; Male; Naloxone; Naltrexone; Outcome and Process Assessment, Health Care; Patient Dropouts

1980
Repeated administration of naltrexone produces tolerance to naloxone-induced hyperalgesia.
    Life sciences, 1980, Nov-17, Volume: 27, Issue:20

    Topics: Animals; Drug Tolerance; Male; Mice; Naloxone; Naltrexone; Pain

1980
The effects of opiate antagonists on the discriminative stimulus properties of ethanol.
    Pharmacology, biochemistry, and behavior, 1981, Volume: 14, Issue:1

    Topics: Animals; Dose-Response Relationship, Drug; Drug Interactions; Ethanol; Generalization, Psychological; Male; Naloxone; Naltrexone; Narcotic Antagonists; Prejudice; Rats

1981
Orally administered opioid antagonists reverse both mu and kappa opioid agonist delay of gastrointestinal transit in the guinea pig.
    Life sciences, 1995, Volume: 56, Issue:14

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Gastrointestinal Transit; Guinea Pigs; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid, kappa; Receptors, Opioid, mu

1995
Characterization of the opioid receptor subtypes mediating the negative inotropic effects of DAMGO, DPDPE and U-50, 488H in isolated human right atria strips.
    Neuropeptides, 1995, Volume: 29, Issue:2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adult; Aged; Analgesics; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Heart Atria; Humans; Male; Middle Aged; Myocardial Contraction; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pyrrolidines; Receptors, Opioid

1995
Ultra-low concentrations of naloxone selectively antagonize excitatory effects of morphine on sensory neurons, thereby increasing its antinociceptive potency and attenuating tolerance/dependence during chronic cotreatment.
    Proceedings of the National Academy of Sciences of the United States of America, 1995, Nov-07, Volume: 92, Issue:23

    Topics: Analgesia; Analgesics, Opioid; Animals; Behavior, Animal; Culture Techniques; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Electrophysiology; Ganglia, Spinal; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Neurons, Afferent; Pain Measurement; Substance Withdrawal Syndrome; Substance-Related Disorders

1995
The in vitro pharmacological characterization of naloxone benzoylhydrazone.
    European journal of pharmacology, 1995, Apr-24, Volume: 277, Issue:2-3

    Topics: Animals; Benzeneacetamides; Binding, Competitive; Computer Simulation; Cyclohexanes; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle, Smooth; Myenteric Plexus; Naloxone; Naltrexone; Narcotic Antagonists; Pyrrolidines; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu

1995
Activity at phencyclidine and mu opioid sites mediates the hyperalgesic and antinociceptive properties of the N-terminus of substance P in a model of visceral pain.
    Neuroscience, 1994, Volume: 60, Issue:2

    Topics: Animals; Biological Assay; Disease Models, Animal; Dizocilpine Maleate; Hyperalgesia; Injections, Spinal; Injections, Subcutaneous; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Peptide Fragments; Phencyclidine; Receptors, Opioid, mu; Spinal Cord; Substance P

1994
Neurotrophic factors in diabetic neuropathy.
    Trends in neurosciences, 1995, Volume: 18, Issue:1

    Topics: Animals; Cells, Cultured; Diabetic Neuropathies; Ganglia, Spinal; Naloxone; Naltrexone; Nerve Growth Factors; Paclitaxel

1995
The opioid peptide dynorphin directly blocks NMDA receptor channels in the rat.
    The Journal of physiology, 1995, Feb-01, Volume: 482 ( Pt 3)

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Dynorphins; In Vitro Techniques; Ion Channels; Naloxone; Naltrexone; Neurons; Patch-Clamp Techniques; Pyrrolidines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa; Structure-Activity Relationship; Trigeminal Nerve

1995
Characterization of the spinal antinociceptive activity of constrained peptidomimetic opioids.
    The Journal of pharmacology and experimental therapeutics, 1995, Volume: 275, Issue:1

    Topics: Amino Acid Sequence; Analgesia; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Endorphins; Enkephalins; Injections, Spinal; Male; Mice; Molecular Sequence Data; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Oligopeptides; Opioid Peptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord; Structure-Activity Relationship; Vas Deferens

1995
Capture of wood bison (Bison bison athabascae) using carfentanil-based mixtures.
    Journal of wildlife diseases, 1995, Volume: 31, Issue:1

    Topics: Analgesics, Opioid; Animals; Bison; Diprenorphine; Drug Combinations; Female; Fentanyl; Hypnotics and Sedatives; Immobilization; Injections, Intramuscular; Injections, Intravenous; Injections, Subcutaneous; Male; Naloxone; Naltrexone; Narcotic Antagonists; Northwest Territories; Piperidines; Tranquilizing Agents; Xylazine

1995
Effect of naltrindole on the development of physical dependence on morphine in mice: a behavioral and biochemical study.
    Life sciences, 1995, Volume: 57, Issue:17

    Topics: Animals; Behavior, Animal; Body Weight; Male; Mice; Mice, Inbred Strains; Morphine Dependence; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Sodium Chloride; Time Factors

1995
Selective actions of central mu and kappa opioid antagonists upon sucrose intake in sham-fed rats.
    Brain research, 1995, Jul-10, Volume: 685, Issue:1-2

    Topics: Animals; Cerebral Ventricles; Eating; Enkephalin, Leucine-2-Alanine; Infusions, Parenteral; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sucrose

1995
Melatonin modifies prolactin release induced by opiate antagonists in male rats.
    Endocrine research, 1995, Volume: 21, Issue:3

    Topics: Animals; Injections, Subcutaneous; Male; Melatonin; Naloxone; Naltrexone; Narcotic Antagonists; Prolactin; Quaternary Ammonium Compounds; Rats; Rats, Wistar

1995
Comparative study of the analgesic and paralytic effects induced by intrathecal dynorphin a in rats.
    The International journal of neuroscience, 1995, Volume: 82, Issue:1-2

    Topics: Analgesics; Animals; Dynorphins; Injections, Spinal; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Pain Threshold; Paralysis; Psychomotor Performance; Rats; Rats, Wistar; Reaction Time; Spinal Cord; Vocalization, Animal

1995
Effects of opioid antagonists naloxone and naltrexone on neuropeptide Y-induced feeding and brown fat thermogenesis in the rat. Neural site of action.
    The Journal of clinical investigation, 1995, Volume: 96, Issue:1

    Topics: Adipose Tissue, Brown; Animals; Brain; Energy Metabolism; Feeding Behavior; Male; Naloxone; Naltrexone; Neuropeptide Y; Obesity; Paraventricular Hypothalamic Nucleus; Rats; Rats, Sprague-Dawley; Solitary Nucleus

1995
Reductions in body weight following chronic central opioid receptor subtype antagonists during development of dietary obesity in rats.
    Brain research, 1995, Apr-24, Volume: 678, Issue:1-2

    Topics: Animals; Body Weight; Dietary Fats; Eating; Male; Naloxone; Naltrexone; Narcotic Antagonists; Obesity; Rats; Rats, Sprague-Dawley; Time Factors

1995
Modification of mu-opioid agonist-induced locomotor activity and development of morphine dependence by diabetes.
    The Journal of pharmacology and experimental therapeutics, 1995, Volume: 274, Issue:2

    Topics: Animals; Diabetes Mellitus, Experimental; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Mice; Mice, Inbred ICR; Morphine; Morphine Dependence; Motor Activity; Naloxone; Naltrexone; Receptors, Opioid, mu; Streptozocin

1995
Blockade of the antinociceptive activity of centrally administered ketorolac by nor-binaltorphimine.
    European journal of pharmacology, 1995, May-04, Volume: 278, Issue:1

    Topics: Analgesia; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Benzoquinones; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, Leucine; Injections, Intraventricular; Ketorolac Tromethamine; Male; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tolmetin; Tromethamine

1995
Mouse strain differences in in vivo and in vitro immunosuppressive effects of opioids.
    Advances in experimental medicine and biology, 1995, Volume: 373

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Erythrocytes; Female; Immunosuppressive Agents; Mice; Mice, Inbred Strains; Morphine; Naloxone; Naltrexone; Opioid Peptides; Pyrrolidines; Species Specificity; Spleen

1995
The modulation of placental lactogen release by opioids: a role for extracellular calcium.
    Molecular and cellular endocrinology, 1993, Volume: 90, Issue:2

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylate Cyclase Toxin; Analgesics; Calcium; Cells, Cultured; Dopamine; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Ethylketocyclazocine; Gene Expression Regulation; Humans; Ionomycin; Naloxone; Naltrexone; Narcotics; Pertussis Toxin; Placental Lactogen; Pyrrolidines; Time Factors; Trophoblasts; Virulence Factors, Bordetella

1993
Analysis of central opioid receptor subtype antagonism of hypotonic and hypertonic saline intake in water-deprived rats.
    Brain research bulletin, 1995, Volume: 36, Issue:3

    Topics: Animals; Enkephalin, Leucine-2-Alanine; Hypotonic Solutions; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Saline Solution, Hypertonic; Water Deprivation

1995
Peripheral kappa-opioid receptors mediate the antinociceptive effect of fedotozine (correction of fetodozine) on the duodenal pain reflex inrat.
    European journal of pharmacology, 1994, Dec-12, Volume: 271, Issue:1

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzyl Compounds; Blood Pressure; Dose-Response Relationship, Drug; Duodenum; Injections, Intravenous; Injections, Intraventricular; Male; Morphine; Naloxone; Naltrexone; Pain; Propylamines; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reflex

1994
Activation of mu-opioid receptor modulates GABAA receptor-mediated currents in isolated spinal dorsal horn neurons.
    Neuroscience letters, 1994, Oct-24, Volume: 180, Issue:2

    Topics: Action Potentials; Amino Acid Sequence; Animals; Bicuculline; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Molecular Sequence Data; Muscimol; Naloxone; Naltrexone; Neurons, Afferent; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Opioid, mu; Spinal Cord

1994
A selective CCKB receptor antagonist potentiates, mu-, but not delta-opioid receptor-mediated antinociception in the formalin test.
    European journal of pharmacology, 1995, Jan-24, Volume: 273, Issue:1-2

    Topics: Analgesics; Animals; Disulfides; Enkephalins; Formaldehyde; Indoles; Male; Meglumine; Mice; Morphine; Naloxone; Naltrexone; Pain Measurement; Phenylalanine; Receptors, Cholecystokinin; Receptors, Opioid, delta; Receptors, Opioid, mu

1995
kappa-Opioid receptor activates an inwardly rectifying K+ channel by a G protein-linked mechanism: coexpression in Xenopus oocytes.
    Molecular pharmacology, 1995, Volume: 47, Issue:5

    Topics: Animals; Benzeneacetamides; Cloning, Molecular; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Gene Expression; GTP-Binding Proteins; In Vitro Techniques; Mice; Naloxone; Naltrexone; Oocytes; Pertussis Toxin; Potassium Channels; Pyrrolidines; Receptors, Opioid, kappa; RNA, Complementary; Virulence Factors, Bordetella; Xenopus

1995
Assessment of endogenous enkephalins efficacy in the hot plate test in mice: comparative study with morphine.
    Neuroscience letters, 1995, Feb-09, Volume: 185, Issue:2

    Topics: Animals; Dose-Response Relationship, Drug; Enkephalins; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Receptors, Opioid, mu

1995
Long-term exposure to opioid antagonists up-regulates prodynorphin gene expression in rat brain.
    Brain research, 1995, Feb-20, Volume: 672, Issue:1-2

    Topics: Animals; Brain; Enkephalins; Gene Expression; Male; Naloxone; Naltrexone; Narcotic Antagonists; Protein Precursors; Rats; Rats, Sprague-Dawley; Time Factors

1995
Endogenous opioids regulate long-term potentiation of synaptic inhibition in the dentate gyrus of rat hippocampus.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1995, Volume: 15, Issue:5 Pt 2

    Topics: 2-Amino-5-phosphonovalerate; Animals; Bicuculline; Electric Stimulation; GABA-A Receptor Antagonists; Hippocampus; Homeostasis; In Vitro Techniques; Long-Term Potentiation; Male; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Opioid Peptides; Patch-Clamp Techniques; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Synapses; Time Factors

1995
Complications with the use of carfentanil citrate and xylazine hydrochloride to immobilize domestic horses.
    Journal of the American Veterinary Medical Association, 1995, Mar-15, Volume: 206, Issue:6

    Topics: Analgesics, Opioid; Animals; Animals, Domestic; Fentanyl; Horse Diseases; Horses; Hypertension; Immobilization; Naloxone; Naltrexone; Pulmonary Edema; Tachycardia; Xylazine

1995
Unexpected prosecretory action component of loperamide at mu-opioid receptors in the guinea-pig colonic mucosa in vitro.
    British journal of pharmacology, 1995, Volume: 114, Issue:4

    Topics: Alprostadil; Amino Acid Sequence; Animals; Chlorides; Colon; Dose-Response Relationship, Drug; Ethylketocyclazocine; Guinea Pigs; Intestinal Mucosa; Loperamide; Male; Molecular Sequence Data; Naloxone; Naltrexone; Patch-Clamp Techniques; Receptors, Opioid, delta; Receptors, Opioid, mu; Somatostatin; Theophylline

1995
Antinociceptive effect of dihydroetorphine in diabetic mice.
    European journal of pharmacology, 1995, Feb-24, Volume: 275, Issue:1

    Topics: Analgesia; Analgesics, Opioid; Animals; Binding, Competitive; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Etorphine; Injections, Intraperitoneal; Injections, Intraventricular; Injections, Subcutaneous; Male; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Receptors, Opioid, delta; Receptors, Opioid, mu

1995
Evidence that beta-endorphin is an agonist at bovine pineal delta-opioid receptors.
    European journal of pharmacology, 1995, Feb-15, Volume: 288, Issue:3

    Topics: Animals; beta-Endorphin; Binding, Competitive; Cattle; Dose-Response Relationship, Drug; Guanylyl Imidodiphosphate; In Vitro Techniques; Naloxone; Naltrexone; Pineal Gland; Receptors, Opioid, delta

1995
Effects of methylnaltrexone on morphine-induced inhibition of contraction in isolated guinea-pig ileum and human intestine.
    European journal of pharmacology, 1995, Mar-24, Volume: 276, Issue:1-2

    Topics: Adult; Aged; Animals; Gastrointestinal Motility; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Intestine, Small; Middle Aged; Morphine; Muscle Contraction; Naloxone; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds

1995
Effect of intracerebroventricular beta-funaltrexamine on mu opioid receptors in the rat brain: consideration of binding condition.
    The Journal of pharmacology and experimental therapeutics, 1995, Volume: 273, Issue:3

    Topics: Analgesics; Animals; Binding, Competitive; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Tritium

1995
Role of endogenous opioid peptides in central glucocorticoid receptor (GR)-induced decreases in circulating LH in the male rat.
    Neuropeptides, 1995, Volume: 28, Issue:3

    Topics: Androstanols; Animals; Arcuate Nucleus of Hypothalamus; Depression, Chemical; Dexamethasone; Gonadotropin-Releasing Hormone; Injections; Injections, Intraventricular; Injections, Subcutaneous; Luteinizing Hormone; Male; Naloxone; Naltrexone; Neurons; Opioid Peptides; Rats; Rats, Sprague-Dawley; Receptors, Glucocorticoid; Receptors, Opioid; Secretory Rate

1995
Effect of diabetes on the morphine-induced inhibition of gastrointestinal transit.
    Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 1995, Volume: 15, Issue:2

    Topics: Animals; Depression, Chemical; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Gastrointestinal Transit; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Naltrexone

1995
Characterisation of mu-opioid receptors on SH-SY5Y cells using naloxonazine and beta-funaltrexamine.
    European journal of pharmacology, 1994, Aug-16, Volume: 268, Issue:3

    Topics: Amino Acid Sequence; Animals; Brain Neoplasms; Cerebral Cortex; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Humans; Ligands; Molecular Sequence Data; Naloxone; Naltrexone; Neuroblastoma; Rats; Receptors, Opioid, mu; Somatostatin; Tumor Cells, Cultured

1994
Properties of delta opioid receptor in neuroblastoma NS20Y: receptor activation and neuroblastoma proliferation.
    The Journal of pharmacology and experimental therapeutics, 1995, Volume: 272, Issue:1

    Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Cell Division; Cyclic AMP; Humans; In Vitro Techniques; Mice; Naloxone; Naltrexone; Neuroblastoma; Pertussis Toxin; Receptors, Opioid, delta; Second Messenger Systems; Signal Transduction; Tumor Cells, Cultured; Virulence Factors, Bordetella

1995
Effects of diabetes on the morphine-induced Straub tail reaction in mice.
    Neuroscience letters, 1994, Aug-29, Volume: 178, Issue:1

    Topics: Animals; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred ICR; Morphine; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu; Reference Values; Tail

1994
Central opioid receptor subtype mediation of isoproterenol-induced drinking in rats.
    Brain research, 1994, 09-19, Volume: 657, Issue:1-2

    Topics: Animals; Drinking; Enkephalin, Leucine-2-Alanine; Injections, Intraventricular; Injections, Subcutaneous; Isoproterenol; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, mu

1994
Morphine-induced straub tail response: mediated by central mu2-opioid receptor.
    European journal of pharmacology, 1994, Sep-22, Volume: 263, Issue:1-2

    Topics: Analgesia; Animals; Female; Injections, Intraventricular; Male; Mice; Morphine; Naloxone; Naltrexone; Receptors, Opioid, mu; Tail

1994
Naloxone pretreatment blocks acute morphine-induced sensitization to naltrexone.
    Psychopharmacology, 1994, Volume: 114, Issue:2

    Topics: Animals; Conditioning, Operant; Dose-Response Relationship, Drug; Male; Morphine; Naloxone; Naltrexone; Rats; Rats, Sprague-Dawley; Reinforcement Schedule

1994
Effect of selective mu 1, mu 2 and delta 2 opioid receptor agonists on gastric functions in the rat.
    Neuropharmacology, 1994, Volume: 33, Issue:8

    Topics: Animals; Dose-Response Relationship, Drug; Gastric Acid; Gastric Emptying; Injections, Intraventricular; Injections, Subcutaneous; Male; Naloxone; Naltrexone; Oligopeptides; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Stomach

1994
Endogenous kappa-opioid systems in opiate withdrawal: role in aversion and accompanying changes in mesolimbic dopamine release.
    Psychopharmacology, 1994, Volume: 115, Issue:1-2

    Topics: Animals; Behavior, Animal; Biogenic Monoamines; Conditioning, Operant; Dopamine; Injections, Intraventricular; Limbic System; Male; Microdialysis; Morphine Dependence; Naloxone; Naltrexone; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reinforcement, Psychology; Substance Withdrawal Syndrome

1994
Both T cells and macrophages are targets of kappa-opioid-induced immunosuppression.
    Brain, behavior, and immunity, 1994, Volume: 8, Issue:3

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Antibody Formation; Cell Separation; Cells, Cultured; Depression, Chemical; Lymphocyte Activation; Lymphocyte Cooperation; Macrophage Activation; Macrophages, Peritoneal; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Naloxone; Naltrexone; Neuroimmunomodulation; Pyrrolidines; Receptors, Opioid, kappa; Rosette Formation; Specific Pathogen-Free Organisms; T-Lymphocytes

1994
kappa-Opioid receptor-transfected cell lines: modulation of adenylyl cyclase activity following acute and chronic opioid treatments.
    FEBS letters, 1995, Mar-13, Volume: 361, Issue:1

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Animals; Benzeneacetamides; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Etorphine; GTP-Binding Proteins; Naloxone; Naltrexone; Opioid Peptides; Pertussis Toxin; Pyrrolidines; Receptors, Opioid, kappa; Virulence Factors, Bordetella

1995
Endogenous opioids and opiate antagonists in autism: brief review of empirical findings and implications for clinicians.
    Developmental medicine and child neurology, 1995, Volume: 37, Issue:3

    Topics: Autistic Disorder; Brain; Endorphins; Humans; Infant, Newborn; Melatonin; Naloxone; Naltrexone; Self-Injurious Behavior; Serotonin

1995
Peripheral effects of naloxone in mice with acute diarrhea associated with intestinal inflammation.
    The Journal of pharmacology and experimental therapeutics, 1995, Volume: 272, Issue:3

    Topics: Acute Disease; Animals; Benzomorphans; Croton Oil; Diarrhea; Enteritis; Gastrointestinal Motility; Male; Mice; Naloxone; Naltrexone; Quaternary Ammonium Compounds; Receptors, Opioid, delta; Receptors, Opioid, kappa

1995
The kappa opioid receptor expressed on the mouse R1.1 thymoma cell line down-regulates without desensitizing during chronic opioid exposure.
    The Journal of pharmacology and experimental therapeutics, 1995, Volume: 272, Issue:3

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Benzeneacetamides; Cell Membrane; Down-Regulation; In Vitro Techniques; Mice; Naloxone; Naltrexone; Pertussis Toxin; Pyrrolidines; Receptors, Opioid, kappa; Thymoma; Tumor Cells, Cultured; Virulence Factors, Bordetella

1995
Differential regulation of adenylyl cyclase activity by mu and delta opioids in rat caudate putamen and nucleus accumbens.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 267, Issue:1

    Topics: Adenylyl Cyclases; Amino Acid Sequence; Animals; Benzeneacetamides; Caudate Nucleus; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Male; Molecular Sequence Data; Naloxone; Naltrexone; Nucleus Accumbens; Oligopeptides; Putamen; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Signal Transduction; Somatostatin

1993
Mechanism of action of CCK in avian gastroduodenal motility: evidence for nitric oxide involvement.
    The American journal of physiology, 1993, Volume: 265, Issue:5 Pt 1

    Topics: Animals; Arginine; Atropine; Chickens; Duodenum; Electromyography; Female; Gastrointestinal Motility; Hexamethonium; Hexamethonium Compounds; Male; Membrane Potentials; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Phentolamine; Propranolol; Sincalide; Stomach; Vagotomy

1993
The kappa-opioid receptor agonist U50,488H induces acute physical dependence in guinea-pigs.
    European journal of pharmacology, 1993, Sep-14, Volume: 241, Issue:2-3

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Behavior, Animal; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine Dependence; Motor Activity; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Pyrrolidines; Receptors, Opioid, kappa; Substance Withdrawal Syndrome; Substance-Related Disorders

1993
Inhibiting a spinal dynorphin A component enhances intrathecal morphine antinociception in mice.
    Anesthesia and analgesia, 1993, Volume: 77, Issue:6

    Topics: Analgesics; Animals; Cerebral Ventricles; Dynorphins; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Spine

1993
Dynorphin A(1-17) mediates midazolam antagonism of morphine antinociception in mice.
    Pharmacology, biochemistry, and behavior, 1993, Volume: 46, Issue:2

    Topics: Analgesics; Animals; Clonidine; Dose-Response Relationship, Drug; Dynorphins; GABA Antagonists; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Midazolam; Morphine; Naloxone; Naltrexone; Pain Measurement; Reaction Time; Spinal Cord

1993
Etonitazene-induced antinociception in mu1 opioid receptor deficient CXBK mice: evidence for a role for mu2 receptors in supraspinal antinociception.
    Life sciences, 1994, Volume: 54, Issue:21

    Topics: Animals; Benzimidazoles; Cerebral Ventricles; Dose-Response Relationship, Drug; Enkephalin, Leucine; Hot Temperature; Injections, Intraventricular; Injections, Subcutaneous; Male; Mice; Mice, Inbred ICR; Mice, Mutant Strains; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Receptors, Opioid, mu; Spinal Cord

1994
Kappa opioids inhibit induction of long-term potentiation in the dentate gyrus of the guinea pig hippocampus.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1994, Volume: 14, Issue:8

    Topics: Animals; Benzeneacetamides; Dynorphins; Electric Stimulation; Guinea Pigs; Hippocampus; Long-Term Potentiation; Male; Naloxone; Naltrexone; Pyrrolidines; Receptors, Opioid, kappa; Synaptic Transmission

1994
Mu- and kappa-opioid receptors selectively reduce the same transient components of high-threshold calcium current in rat dorsal root ganglion sensory neurons.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1994, Volume: 14, Issue:10

    Topics: Analgesics; Animals; Benzeneacetamides; Calcium; Calcium Channels; Dynorphins; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Evoked Potentials; Ganglia, Spinal; In Vitro Techniques; Naloxone; Naltrexone; Narcotic Antagonists; Neurons, Afferent; Pyrrolidines; Rats; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reference Values; Sensitivity and Specificity

1994
A mechanism of action for morphine-induced immunosuppression: corticosterone mediates morphine-induced suppression of natural killer cell activity.
    The Journal of pharmacology and experimental therapeutics, 1994, Volume: 270, Issue:3

    Topics: Animals; Cells, Cultured; Corticosterone; Female; Immunosuppressive Agents; Killer Cells, Natural; Mice; Morphine; Naloxone; Naltrexone; Receptors, Opioid; Spleen

1994
Nalorphine as a stimulus in drug discrimination learning: assessment of the role of mu- and kappa-receptor subtypes.
    Pharmacology, biochemistry, and behavior, 1994, Volume: 48, Issue:3

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Diprenorphine; Discrimination Learning; Dose-Response Relationship, Drug; Female; Generalization, Stimulus; Nalorphine; Naloxone; Naltrexone; Pyrrolidines; Rats; Receptors, Opioid, kappa; Receptors, Opioid, mu

1994
Morphine reduces the release of met-enkephalin-like material from the rat spinal cord in vivo by acting at delta opioid receptors.
    Neuropeptides, 1994, Volume: 27, Issue:1

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Injections, Spinal; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pyrrolidines; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Spinal Cord

1994
Species difference in the modulatory effect of kappa agonist on 5-HT release from ground squirrel and rat hippocampus.
    Neuroscience letters, 1994, Jul-04, Volume: 175, Issue:1-2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Aging; Animals; Dose-Response Relationship, Drug; Female; Hippocampus; In Vitro Techniques; Male; Naloxone; Naltrexone; Potassium; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Sciuridae; Serotonin; Species Specificity; Tetrodotoxin

1994
Beta-funaltrexamine blockade of opioid-induced inhibition of somatostatin secretion from rat stomach.
    European journal of pharmacology, 1994, Jul-11, Volume: 259, Issue:3

    Topics: Amino Acid Sequence; Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Gastric Inhibitory Polypeptide; Gastric Mucosa; In Vitro Techniques; Male; Molecular Sequence Data; Naloxone; Naltrexone; Narcotic Antagonists; Radioimmunoassay; Rats; Rats, Wistar; Somatostatin

1994
Role of endogenous cholecystokinin in the facilitation of mu-mediated antinociception by delta-opioid agonists.
    The Journal of pharmacology and experimental therapeutics, 1994, Volume: 271, Issue:3

    Topics: Amino Acid Sequence; Analgesia; Animals; Benzodiazepinones; Cholecystokinin; Devazepide; Disulfides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Mice; Molecular Sequence Data; Naloxone; Naltrexone; Oligopeptides; Peptide Fragments; Phenylalanine; Receptors, Opioid, delta; Receptors, Opioid, mu; Sincalide

1994
Streptozotocin-induced diabetes selectively reduces antinociception mediated by mu 1-opioid receptors, but not that mediated by mu 2-opioid receptors.
    Neuroscience letters, 1994, Jan-03, Volume: 165, Issue:1-2

    Topics: Analgesics; Animals; Diabetes Mellitus, Experimental; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Receptors, Opioid, mu; Spinal Cord

1994
Microwave irradiation affects radial-arm maze performance in the rat.
    Bioelectromagnetics, 1994, Volume: 15, Issue:2

    Topics: Analysis of Variance; Animals; Learning; Male; Memory; Microwaves; Naloxone; Naltrexone; Physostigmine; Rats; Rats, Sprague-Dawley; Reference Values; Time Factors

1994
Characterization of opioid binding sites in the neural and intermediate lobe of the rat pituitary gland by quantitative receptor autoradiography.
    Journal of neuroendocrinology, 1994, Volume: 6, Issue:1

    Topics: Amino Acid Sequence; Analgesics; Animals; Autoradiography; Benzomorphans; Binding, Competitive; Densitometry; Enkephalins; Ligands; Male; Molecular Sequence Data; Naloxone; Naltrexone; Pituitary Gland; Pituitary Gland, Posterior; Protein Precursors; Rats; Rats, Wistar; Receptors, Opioid; Receptors, Opioid, kappa

1994
TRIMU-5, a mu 2-opioid receptor agonist, stimulates the hypothalamo-pituitary-adrenal axis.
    Pharmacology, biochemistry, and behavior, 1994, Volume: 47, Issue:4

    Topics: Animals; Corticosterone; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hypothalamo-Hypophyseal System; Kinetics; Male; Naloxone; Naltrexone; Oligopeptides; Pituitary-Adrenal System; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu

1994
Lack of involvement of delta-1 opioid receptors in the development of physical dependence on morphine in mice.
    The Journal of pharmacology and experimental therapeutics, 1994, Volume: 270, Issue:1

    Topics: Affinity Labels; Animals; Diarrhea; Enkephalin, Leucine-2-Alanine; Injections, Intraventricular; Injections, Spinal; Isothiocyanates; Male; Mice; Morphine; Naloxone; Naltrexone; Receptors, Opioid, delta; Substance-Related Disorders

1994
Agonists and antagonists bind to different domains of the cloned kappa opioid receptor.
    Proceedings of the National Academy of Sciences of the United States of America, 1994, Aug-16, Volume: 91, Issue:17

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Base Sequence; Benzeneacetamides; Binding Sites; Cell Line; Chlorocebus aethiops; Cloning, Molecular; Colforsin; Cyclic AMP; Enkephalin, Leucine; Kinetics; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Naloxone; Naltrexone; Oligodeoxyribonucleotides; Protein Structure, Secondary; Pyrrolidines; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, kappa; Recombinant Fusion Proteins; Recombinant Proteins; Transfection

1994
Involvement of kappa-opioid receptors in opioid dependence/withdrawal: studies using butorphanol.
    European journal of pharmacology, 1994, May-12, Volume: 257, Issue:1-2

    Topics: Animals; Butorphanol; Injections, Intraventricular; Male; Naloxone; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Substance Withdrawal Syndrome; Substance-Related Disorders

1994
Role of vagal afferents in the antinociception produced by morphine and U-50,488H in the colonic pain reflex in rats.
    European journal of pharmacology, 1994, May-12, Volume: 257, Issue:1-2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Blood Pressure; Colon; Injections, Intraventricular; Injections, Spinal; Male; Morphine; Naloxone; Naltrexone; Neurons, Afferent; Pain; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reflex; Vagotomy; Vagus Nerve

1994
The use of specific opioid agonists and antagonists to delineate the vagally mediated antinociceptive and cardiovascular effects of intravenous morphine.
    Brain research, 1993, Feb-19, Volume: 603, Issue:2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analysis of Variance; Animals; Blood Pressure; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Heart Rate; Hexamethonium; Hexamethonium Compounds; Indoles; Injections, Intravenous; Male; Morphinans; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pain; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reference Values; Time Factors; Vagotomy; Vagus Nerve

1993
Endogenous dynorphin modulates calcium-mediated antinociception in mice.
    Pharmacology, biochemistry, and behavior, 1993, Volume: 45, Issue:2

    Topics: Animals; Calcium; Dynorphins; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Nociceptors; Peptide Fragments; Phenobarbital

1993
Repeated exposure of rat pups to isolation attenuates isolation-induced ultrasonic vocalization rates: reversal with naltrexone.
    Developmental psychobiology, 1994, Volume: 27, Issue:1

    Topics: Animals; Arousal; Dose-Response Relationship, Drug; Female; Habituation, Psychophysiologic; Male; Naloxone; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Social Isolation; Vocalization, Animal

1994
Interaction of beta-endorphin and GABAergic drugs in the regulation of memory storage.
    Behavioral and neural biology, 1993, Volume: 60, Issue:2

    Topics: Animals; Avoidance Learning; beta-Endorphin; Bicuculline; Conditioning, Classical; Dose-Response Relationship, Drug; Electroshock; Fear; Injections, Intraperitoneal; Male; Mice; Muscimol; Naloxone; Naltrexone; Picrotoxin; Reaction Time; Receptors, GABA; Receptors, Opioid; Retention, Psychology

1993
Characterization of the mu-opioid receptors on SH-SY5Y cells using beta-funaltrexamine (beta-FNA) and naloxonazine.
    Biochemical Society transactions, 1993, Volume: 21, Issue:4

    Topics: Analgesics; Cell Line; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Humans; Kinetics; Naloxone; Naltrexone; Narcotic Antagonists; Neuroblastoma; Receptors, Opioid, mu; Tumor Cells, Cultured

1993
Influence of selective opiate antagonists on striatal acetylcholine and dopamine release.
    Acta physiologica Hungarica, 1993, Volume: 81, Issue:1

    Topics: Acetylcholine; Animals; Corpus Striatum; Dopamine; Electric Stimulation; In Vitro Techniques; Male; Naloxone; Naltrexone; Narcotic Antagonists; Oxidopamine; Rats; Rats, Wistar

1993
Antagonistic effects of the selective, competitive N-methyl-D-aspartate (NMDA) receptor antagonist, NPC 12626, on kappa opiate-induced analgesia in male deer mice.
    Brain research, 1994, Feb-21, Volume: 637, Issue:1-2

    Topics: Amino Acids; Analgesics; Animals; Benzeneacetamides; Dizocilpine Maleate; Dose-Response Relationship, Drug; Male; Morphine; Naloxone; Naltrexone; Nociceptors; Pain Measurement; Peromyscus; Pyrrolidines; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa

1994
The role of multiple opioid receptors in the maintenance of stimulation-induced feeding.
    Brain research, 1994, Mar-07, Volume: 639, Issue:1

    Topics: Amino Acid Sequence; Animals; Differential Threshold; Dose-Response Relationship, Drug; Eating; Electric Stimulation; Hypothalamic Area, Lateral; Male; Molecular Sequence Data; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid

1994
Effect of a peripheral and a central acting opioid antagonist on the testicular response to stress in rats.
    Neuroendocrinology, 1994, Volume: 59, Issue:4

    Topics: Aldehyde-Lyases; Animals; Corticosterone; Cytochrome P-450 Enzyme System; Immobilization; Kinetics; Luteinizing Hormone; Male; Naloxone; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Rats; Rats, Wistar; Steroid 17-alpha-Hydroxylase; Stress, Psychological; Testis; Testosterone

1994
Acute sensitization to opioid antagonists.
    Pharmacology, biochemistry, and behavior, 1994, Volume: 47, Issue:3

    Topics: Animals; Conditioning, Operant; Dose-Response Relationship, Drug; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Reinforcement Schedule; Stereoisomerism

1994
Antinociceptive effect of dihydroetorphine and its tolerance/dependence liability in mice.
    Biological & pharmaceutical bulletin, 1993, Volume: 16, Issue:8

    Topics: Analgesics; Animals; Body Weight; Drug Tolerance; Etorphine; Male; Mice; Mice, Inbred Strains; Morphine; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Substance-Related Disorders

1993
Differential effects of specific delta and kappa opioid receptor antagonists on the bidirectional dose-dependent effect of systemic naloxone in arthritic rats, an experimental model of persistent pain.
    Brain research, 1993, Oct-01, Volume: 623, Issue:2

    Topics: Analysis of Variance; Animals; Arthritis; Benzomorphans; Dose-Response Relationship, Drug; Injections, Intravenous; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Pain; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Vocalization, Animal

1993
Multiple opioid system involvement in the mediation of parasitic-infection induced analgesia.
    Brain research, 1993, Oct-01, Volume: 623, Issue:2

    Topics: Analgesia; Animals; Coccidiosis; Endorphins; Enkephalin, Leucine; Host-Parasite Interactions; Male; Mice; Mice, Inbred Strains; Naloxone; Naltrexone; Narcotic Antagonists

1993
Naloxone-induced analgesia: involvement of kappa-opiate receptors.
    Pharmacology, biochemistry, and behavior, 1993, Volume: 46, Issue:1

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics; Animals; Benzomorphans; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pain Threshold; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu

1993
Opioid antagonist-induced receptor upregulation: effects of concurrent agonist administration.
    Brain research bulletin, 1994, Volume: 33, Issue:2

    Topics: Animals; Brain; Drug Combinations; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Fentanyl; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu; Up-Regulation

1994
Delta-opioid receptor antagonists attenuate motor activity induced by amphetamine but not cocaine.
    European journal of pharmacology, 1993, Nov-09, Volume: 249, Issue:2

    Topics: Amphetamine; Animals; Cocaine; Dose-Response Relationship, Drug; Enkephalin, Leucine-2-Alanine; Male; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta

1993
The effect of nalmefene on pulsatile secretion of luteinizing hormone and prolactin in men.
    Human reproduction (Oxford, England), 1993, Volume: 8, Issue:10

    Topics: Adult; Endorphins; Humans; Luteinizing Hormone; Male; Naloxone; Naltrexone; Prolactin; Secretory Rate

1993
Sex differences in the antinociceptive effects of the enkephalinase inhibitor, SCH 34826.
    Pharmacology, biochemistry, and behavior, 1993, Volume: 46, Issue:4

    Topics: Analgesia; Analgesics; Animals; Dioxolanes; Dipeptides; Enkephalin, Leucine; Female; Male; Naloxone; Naltrexone; Narcotic Antagonists; Neprilysin; Peromyscus; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Restraint, Physical; Sex Characteristics; Stress, Psychological

1993
Long-term naltrexone treatment reduces the exaggerated insulin secretion in patients with polycystic ovary disease.
    Obstetrics and gynecology, 1993, Volume: 82, Issue:2

    Topics: Adult; Endorphins; Female; Glucose Tolerance Test; Gonadal Steroid Hormones; Humans; Hyperinsulinism; Insulin; Naloxone; Naltrexone; Obesity; Polycystic Ovary Syndrome; Time Factors

1993
The role of endogenous opioids as mediators of the hypothermic effects of intrathecally administered calcium and calcitonin gene-related peptide in mice.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 266, Issue:3

    Topics: Animals; Body Temperature Regulation; Calcitonin Gene-Related Peptide; Calcium; Dose-Response Relationship, Drug; Drug Interactions; Endorphins; Hypothalamus; Hypothermia, Induced; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Time Factors

1993
Opioid-induced stimulation of fetal respiratory activity by [D-Ala2]deltorphin I.
    European journal of pharmacology, 1993, Jan-05, Volume: 230, Issue:1

    Topics: Animals; Dose-Response Relationship, Drug; Electromyography; Female; Fetus; Indoles; Injections, Intraventricular; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pregnancy; Receptors, Opioid, delta; Respiration; Sheep

1993
Relative involvement of supraspinal and spinal mu opioid receptors in morphine dependence in mice.
    Life sciences, 1993, Volume: 52, Issue:12

    Topics: Animals; Brain; Cerebral Ventricles; Diarrhea; Injections, Intraventricular; Injections, Spinal; Male; Mice; Morphine Dependence; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu; Spinal Cord; Substance Withdrawal Syndrome

1993
Involvement of delta 2 opioid receptors in the development of morphine dependence in mice.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 264, Issue:3

    Topics: Animals; Enkephalin, Leucine; Isothiocyanates; Male; Mice; Morphinans; Morphine Dependence; Naloxone; Naltrexone; Receptors, Opioid, delta; Substance Withdrawal Syndrome; Thiocyanates

1993
Involvement of mu1 and mu2 opioid receptor subtypes in tail-pinch feeding in rats.
    Physiology & behavior, 1993, Volume: 53, Issue:3

    Topics: Animals; Arousal; Enkephalin, Leucine-2-Alanine; Feeding Behavior; Indoles; Male; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu

1993
Independent expression of two pharmacologically distinct supraspinal mu analgesic systems in genetically different mouse strains.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 265, Issue:1

    Topics: Analgesia; Animals; Brain Stem; Drug Administration Routes; Male; Mice; Morphine; Naloxone; Naltrexone; Receptors, Opioid, mu; Species Specificity; Spinal Cord

1993
Anticonvulsant effects of U-54494A and U-50488H in genetically epilepsy-prone rats and DBA/2 mice: a possible involvement of glycine/NMDA receptor complex.
    General pharmacology, 1993, Volume: 24, Issue:2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Anticonvulsants; Epilepsy; Female; Male; Mice; Mice, Inbred DBA; Motor Activity; Naloxone; Naltrexone; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Opioid, kappa; Serine

1993
Effects of the kappa-opioid agonist U50,488 on parturition in rats.
    British journal of pharmacology, 1993, Volume: 109, Issue:1

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Female; Infusions, Intravenous; Injections, Intravenous; Labor, Obstetric; Male; Morphine; Naloxone; Naltrexone; Oxytocin; Pregnancy; Pyrrolidines; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Opioid, kappa; Uterine Contraction

1993
Withdrawal contractures of guinea-pig isolated ileum after acute activation of kappa-opioid receptors.
    British journal of pharmacology, 1993, Volume: 109, Issue:1

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Clonidine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Nifedipine; Pyrrolidines; Receptors, Opioid, kappa; Substance Withdrawal Syndrome

1993
L-arginine exerts a dual role in nociceptive processing in the brain: involvement of the kyotorphin-Met-enkephalin pathway and NO-cyclic GMP pathway.
    British journal of pharmacology, 1993, Volume: 109, Issue:1

    Topics: Analgesics; Animals; Arginine; Brain; Cyclic GMP; Endorphins; Enkephalin, Methionine; Injections, Intraventricular; Male; Methylene Blue; Mice; Mice, Inbred Strains; Naloxone; Naltrexone; Narcotic Antagonists; Neural Pathways; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nociceptors; Pain Measurement; Spinal Cord

1993
Evidence for an opioid inhibitory effect on T cell proliferation.
    Journal of neuroimmunology, 1993, Volume: 44, Issue:1

    Topics: Adult; Animals; beta-Endorphin; Cell Division; Concanavalin A; Female; Humans; Male; Middle Aged; Naloxone; Naltrexone; Narcotics; Phytohemagglutinins; Rats; Rats, Sprague-Dawley; Receptors, Opioid; T-Lymphocytes

1993
Blockade of cannabinoid-induced antinociception by norbinaltorphimine, but not N,N-diallyl-tyrosine-Aib-phenylalanine-leucine, ICI 174,864 or naloxone in mice.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 265, Issue:2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Dronabinol; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Infusions, Intravenous; Injections, Spinal; Mice; Naloxone; Naltrexone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta

1993
Opioid control of the release of calcitonin gene-related peptide-like material from the rat spinal cord in vivo.
    Brain research, 1993, Apr-23, Volume: 609, Issue:1-2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Calcitonin Gene-Related Peptide; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Spinal; Iodine Radioisotopes; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pyrrolidines; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord

1993
Effect of antagonists selective for mu, delta and kappa opioid receptors on the reinforcing effects of heroin in rats.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 265, Issue:3

    Topics: Animals; Heroin; Male; Naloxone; Naltrexone; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Self Administration

1993
CRF alters the infundibular LHRH secretory system from the medial preoptic area of female rats: possible involvement of opioid receptors.
    Neuroendocrinology, 1993, Volume: 57, Issue:2

    Topics: Animals; Corticotropin-Releasing Hormone; Female; Gonadotropin-Releasing Hormone; Hypothalamus; Kinetics; Luteinizing Hormone; Naloxone; Naltrexone; Ovariectomy; Preoptic Area; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu

1993
Dose-dependent antagonism of spinal opioid receptor agonists by naloxone and naltrindole: additional evidence for delta-opioid receptor subtypes in the rat.
    European journal of pharmacology, 1993, May-12, Volume: 236, Issue:1

    Topics: Analgesics; Animals; Binding, Competitive; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; In Vitro Techniques; Injections, Spinal; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord

1993
Alpha-interferon inhibits adrenocortical secretion via mu 1-opioid receptors in the rat.
    European journal of pharmacology, 1993, May-19, Volume: 236, Issue:2

    Topics: Animals; Corticosterone; Hypothalamo-Hypophyseal System; Injections, Intraperitoneal; Injections, Intraventricular; Interferon-alpha; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pituitary-Adrenal System; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Swimming

1993
Mode of action of interleukin-1 in suppression of pituitary LH release in castrated male rats.
    Brain research, 1993, May-28, Volume: 612, Issue:1-2

    Topics: Animals; Corticotropin-Releasing Hormone; Depression, Chemical; Hypothalamus; Injections, Intraventricular; Interleukin-1; Luteinizing Hormone; Male; Naloxone; Naltrexone; Narcotic Antagonists; Orchiectomy; Pituitary Gland; Rats; Receptors, Opioid

1993
Opioid-induced suppression of rat testicular function.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 266, Issue:1

    Topics: Animals; Dose-Response Relationship, Drug; Drug Interactions; Endorphins; Extracellular Space; Gonadotropins; Hypothalamo-Hypophyseal System; Luteinizing Hormone; Male; Morphine; Naloxone; Naltrexone; Pituitary-Adrenal System; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Testis; Testosterone; Time Factors

1993
The highly selective delta agonist BUBU induces an analgesic effect in normal and arthritic rat and this action is not affected by repeated administration of low doses of morphine.
    Brain research, 1993, May-21, Volume: 611, Issue:2

    Topics: Analgesics; Animals; Arthritis, Experimental; Drug Administration Schedule; Drug Interactions; Enkephalins; Male; Morphine; Naloxone; Naltrexone; Oligopeptides; Pain; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Reference Values; Vocalization, Animal

1993
Involvement of spinal kappa opioid receptors in a type of footshock induced analgesia in mice.
    Brain research, 1993, May-21, Volume: 611, Issue:2

    Topics: Analgesia; Animals; Cerebral Ventricles; Electroshock; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Receptors, Opioid, kappa; Spinal Cord; Stress, Psychological

1993
Selective opioid receptor agonists modulate mechanical allodynia in an animal model of neuropathic pain.
    Pain, 1993, Volume: 53, Issue:3

    Topics: Analgesics; Animals; Benzeneacetamides; Benzomorphans; Disease Models, Animal; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain; Pain Measurement; Pain Threshold; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vocalization, Animal

1993
DAMGO stimulates the hypothalamo-pituitary-adrenal axis through a mu-2 opioid receptor.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 266, Issue:2

    Topics: Analgesics; Animals; Corticosterone; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hypothalamo-Hypophyseal System; Male; Naloxone; Naltrexone; Pituitary-Adrenal System; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu

1993
Effect of delayed weaning on opioid receptor control of swim stress-induced antinociception in the developing rat.
    British journal of pharmacology, 1993, Volume: 109, Issue:3

    Topics: Alfentanil; Analgesia; Animals; Female; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Rats; Rats, Wistar; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Stress, Psychological; Swimming; Weaning

1993
Role of mu 1- and delta-opioid receptors in modulation of fetal EEG and respiratory activity.
    The American journal of physiology, 1993, Volume: 265, Issue:2 Pt 2

    Topics: Animals; Electroencephalography; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fetal Movement; Fetus; Morphine; Naloxone; Naltrexone; Receptors, Opioid, delta; Receptors, Opioid, mu; Respiration; Sheep

1993
Chronic kappa opioid receptor antagonism produces supersensitivity to U-50,488H at the hypothalamo-pituitary-adrenocortical (HPA) axis level.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 266, Issue:3

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Body Weight; Corticosterone; Dose-Response Relationship, Drug; Hyperalgesia; Hypothalamo-Hypophyseal System; Male; Naloxone; Naltrexone; Pituitary-Adrenal System; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Sensitivity and Specificity; Sodium Chloride

1993
Central opioid receptor subtype antagonists differentially reduce intake of saccharin and maltose dextrin solutions in rats.
    Brain research, 1993, Aug-06, Volume: 618, Issue:2

    Topics: Animals; Drinking Behavior; Enkephalin, Leucine-2-Alanine; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Polysaccharides; Rats; Rats, Sprague-Dawley; Saccharin

1993
Antagonist effects of beta-funaltrexamine and naloxonazine on alfentanil-induced antinociception and muscle rigidity in the rat.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 264, Issue:2

    Topics: Alfentanil; Analgesia; Animals; Electromyography; Male; Muscle Rigidity; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar

1993
Effects of a 60 Hz magnetic field on central cholinergic systems of the rat.
    Bioelectromagnetics, 1993, Volume: 14, Issue:1

    Topics: Animals; Brain; Choline; Electromagnetic Fields; Male; Naloxone; Naltrexone; Parasympathetic Nervous System; Rats; Rats, Sprague-Dawley

1993
Influence of hyperkalaemia and ischaemia on non-receptor-mediated cardiac electrophysiological effects of naloxone.
    Cardiovascular research, 1993, Volume: 27, Issue:2

    Topics: Action Potentials; Animals; Culture Techniques; Dose-Response Relationship, Drug; Electrophysiology; Heart Conduction System; Hyperkalemia; Morphine; Myocardial Ischemia; Naloxone; Naltrexone; Narcotic Antagonists; Rabbits; Refractory Period, Electrophysiological

1993
Ultrashort noninvasive opiate detoxification.
    The American journal of psychiatry, 1993, Volume: 150, Issue:5

    Topics: Adult; Heroin Dependence; Humans; Male; Midazolam; Naloxone; Naltrexone; Ondansetron; Substance Withdrawal Syndrome; Time Factors

1993
Measurement of naloxone in plasma using high-performance liquid chromatography with electrochemical detection.
    Journal of chromatography, 1993, Apr-21, Volume: 614, Issue:1

    Topics: Chromatography, High Pressure Liquid; Electrochemistry; Humans; Naloxone; Naltrexone; Oxidation-Reduction; Reference Values; Reproducibility of Results; Sensitivity and Specificity

1993
Opioid and nonopioid interactions in two forms of stress-induced analgesia.
    Pharmacology, biochemistry, and behavior, 1993, Volume: 45, Issue:1

    Topics: Analgesia; Animals; Body Temperature; Cold Temperature; Male; Morphine; Naloxone; Naltrexone; Rats; Rats, Sprague-Dawley; Reaction Time; Skin Temperature; Social Behavior; Stress, Psychological

1993
Duration of opioid antagonism by nalmefene and naloxone in the dog: an integrated pharmacokinetic/pharmacodynamic comparison.
    Journal of pharmaceutical sciences, 1995, Volume: 84, Issue:9

    Topics: Animals; Blood Gas Monitoring, Transcutaneous; Dogs; Female; Fentanyl; Infusions, Intravenous; Models, Biological; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Respiration

1995
Kappa opioid receptors participate in nerve growth factor-induced hyperalgesia.
    Neuroscience, 1995, Volume: 68, Issue:4

    Topics: Animals; Female; Humans; Hyperalgesia; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Nerve Growth Factors; Pain Measurement; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Proteins

1995
Discriminative stimulus properties of morphine mediated by mu 1-opioid receptors.
    European journal of pharmacology, 1995, Sep-15, Volume: 284, Issue:1-2

    Topics: Analgesics, Opioid; Animals; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred F344; Receptors, Opioid, mu

1995
Attenuation of morphine tolerance and dependence with the highly selective delta-opioid receptor antagonist TIPP[psi].
    European journal of pharmacology, 1995, Nov-03, Volume: 286, Issue:1

    Topics: Animals; Behavior, Animal; Morphine Dependence; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Rats; Receptors, Opioid, delta; Substance Withdrawal Syndrome; Tetrahydroisoquinolines

1995
Duration of opioid antagonism by nalmefene and naloxone in the dog. A nonparametric pharmacodynamic comparison based on generalized cross-validated spline estimation.
    International journal of clinical pharmacology and therapeutics, 1995, Volume: 33, Issue:10

    Topics: Analysis of Variance; Animals; Carbon Dioxide; Computer Simulation; Cross-Over Studies; Dogs; Drug Tolerance; Fentanyl; Injections, Intravenous; Male; Models, Statistical; Naloxone; Naltrexone; Narcotic Antagonists; Respiratory Insufficiency; Time Factors

1995
Opioid antagonists naloxone, beta-funaltrexamine and naltrindole, but not nor-binaltorphimine, reverse the increased hindpaw withdrawal latency in rats induced by intrathecal administration of the calcitonin gene-related peptide antagonist CGRP8-37.
    Brain research, 1995, Nov-06, Volume: 698, Issue:1-2

    Topics: Animals; Calcitonin Gene-Related Peptide; Hindlimb; Hot Temperature; Injections, Spinal; Male; Naloxone; Naltrexone; Narcotic Antagonists; Peptide Fragments; Rats; Rats, Sprague-Dawley; Reaction Time; Reflex; Stress, Mechanical

1995
Electrical stimulation at traditional acupuncture sites in periphery produces brain opioid-receptor-mediated antinociception in rats.
    The Journal of pharmacology and experimental therapeutics, 1996, Volume: 277, Issue:2

    Topics: Acupuncture Therapy; Analgesia; Animals; Brain; Electric Stimulation; Male; Naloxone; Naltrexone; Peptide Fragments; Peptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Somatostatin

1996
Opioid antagonists and antisera to endogenous opioids increase the nociceptive response to formalin: demonstration of an opioid kappa and delta inhibitory tone.
    The Journal of pharmacology and experimental therapeutics, 1996, Volume: 277, Issue:2

    Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Formaldehyde; Immune Sera; Male; Naloxone; Naltrexone; Narcotic Antagonists; Opioid Peptides; Pain; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa

1996
Buprenorphine's physical dependence potential: antagonist-precipitated withdrawal in humans.
    The Journal of pharmacology and experimental therapeutics, 1996, Volume: 276, Issue:2

    Topics: Adult; Analgesics, Opioid; Buprenorphine; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Naloxone; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Substance Withdrawal Syndrome

1996
Interaction of opioids with antidepressant-induced antinociception.
    Psychopharmacology, 1995, Volume: 122, Issue:4

    Topics: Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Clomipramine; Drug Combinations; Female; Imipramine; Male; Maprotiline; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pain Measurement; Random Allocation; Selective Serotonin Reuptake Inhibitors; Zimeldine

1995
Tonic endogenous opioid inhibition of visceral noxious information in rabbits.
    Gastroenterology, 1996, Volume: 111, Issue:1

    Topics: Age Factors; Animals; Benzomorphans; Dose-Response Relationship, Drug; Female; Gastrointestinal Motility; Injections, Intramuscular; Injections, Spinal; Naloxone; Naltrexone; Narcotic Antagonists; Opioid Peptides; Rabbits; Receptors, Opioid

1996
Antinociceptive and behavioral effects of synthetic deltorphin analogs.
    European journal of pharmacology, 1996, Jan-18, Volume: 296, Issue:1

    Topics: Analysis of Variance; Animals; Catalepsy; Dose-Response Relationship, Drug; Injections, Intraventricular; Locomotion; Male; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu

1996
Central antinociceptive effect of L-ornithine, a metabolite of L-arginine, in rats and mice.
    European journal of pharmacology, 1996, Jan-18, Volume: 296, Issue:1

    Topics: Analgesia; Animals; Arginine; Carrageenan; Citrulline; Dipeptides; Dose-Response Relationship, Drug; Excipients; Hyperalgesia; Injections, Intraventricular; Leucine; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Ornithine; Pain Measurement; Protease Inhibitors; Rats

1996
Differential effects of morphine-6-glucuronide, an active metabolite of morphine, and morphine on locomotor activity in mice: involvement of the opioid receptor.
    Pharmacology & toxicology, 1996, Volume: 78, Issue:5

    Topics: Animals; Injections, Subcutaneous; Locomotion; Male; Mice; Mice, Inbred Strains; Morphine; Morphine Derivatives; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid

1996
Distribution of c-Fos in guinea-pig brain following morphine withdrawal.
    Brain research, 1996, Apr-22, Volume: 717, Issue:1-2

    Topics: Analgesics, Opioid; Animals; Brain Chemistry; Female; Guinea Pigs; Locomotion; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Proto-Oncogene Proteins c-fos; Substance Withdrawal Syndrome

1996
Role of delta-opioid receptors in mediating the aversive stimulus effects of morphine withdrawal in the rat.
    European journal of pharmacology, 1996, Apr-04, Volume: 300, Issue:1-2

    Topics: Animals; Dose-Response Relationship, Drug; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Substance Withdrawal Syndrome

1996
Antinociceptive and antitussive effects of morphine in the DA-bg/bg (beige) rat.
    European journal of pharmacology, 1996, Apr-04, Volume: 300, Issue:1-2

    Topics: Analgesics, Opioid; Animals; Capsaicin; Cough; Female; Male; Morphine; Naloxone; Naltrexone; Pain; Rats; Rats, Inbred Strains; Species Specificity

1996
Morphine stimulates phagocytosis of Mycobacterium tuberculosis by human microglial cells: involvement of a G protein-coupled opiate receptor.
    Advances in neuroimmunology, 1995, Volume: 5, Issue:3

    Topics: Adjuvants, Immunologic; Brain; Cells, Cultured; Cholera Toxin; GTP-Binding Proteins; Humans; Microglia; Morphine; Mycobacterium tuberculosis; Naloxone; Naltrexone; Narcotic Antagonists; Neuroimmunomodulation; Pertussis Toxin; Phagocytosis; Receptors, Opioid; Signal Transduction; Virulence Factors, Bordetella

1995
Ocular action of an opioid peptide, DPDPE.
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 1996,Summer, Volume: 12, Issue:2

    Topics: Administration, Topical; Analgesics; Animals; Ciliary Body; Cyclic AMP; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Injections, Intravenous; Intraocular Pressure; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rabbits

1996
Effects of melatonin in vivo upon luteinizing hormone and prolactin releases induced by opiate receptor antagonists in adult male rats.
    Journal of endocrinological investigation, 1996, Volume: 19, Issue:2

    Topics: Animals; Luteinizing Hormone; Male; Melatonin; Naloxone; Naltrexone; Narcotic Antagonists; Prolactin; Quaternary Ammonium Compounds; Rats; Rats, Wistar

1996
Opioid receptor selectivity alteration by single residue replacement: synthesis and activity profile of [Dmt1]deltorphin B.
    European journal of pharmacology, 1996, Apr-29, Volume: 302, Issue:1-3

    Topics: Animals; Mice; Muscle Contraction; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain Threshold; Rabbits; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu

1996
Opioid antagonist profile of SC nor-binaltorphimine in the formalin paw assay.
    Pharmacology, biochemistry, and behavior, 1996, Volume: 53, Issue:2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Formaldehyde; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Pyrroles; Pyrrolidines; Receptors, Opioid, kappa; Receptors, Opioid, mu; Thiophenes

1996
Alcohol drinking is reduced by a mu 1- but not by a delta-opioid receptor antagonist in alcohol-preferring rats.
    European journal of pharmacology, 1996, May-23, Volume: 304, Issue:1-3

    Topics: Alcohol Drinking; Animals; Dose-Response Relationship, Drug; Drinking; Eating; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraperitoneal; Male; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid, delta; Receptors, Opioid, mu

1996
Investigation of the effects of opiate antagonists infused into the nucleus accumbens on feeding and sucrose drinking in rats.
    The Journal of pharmacology and experimental therapeutics, 1996, Volume: 278, Issue:3

    Topics: Animals; Drinking Behavior; Feeding Behavior; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Satiation; Sucrose

1996
Intrathecal Tyr-W-MIF-1 produces potent, naloxone-reversible analgesia modulated by alpha 2-adrenoceptors.
    European journal of pharmacology, 1996, Mar-18, Volume: 298, Issue:3

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Amino Acid Sequence; Animals; Desipramine; Dose-Response Relationship, Drug; Injections, Spinal; Male; Mice; Molecular Sequence Data; MSH Release-Inhibiting Hormone; Naloxone; Naltrexone; Narcotic Antagonists; Norepinephrine; Receptors, Adrenergic, alpha-2; Yohimbine

1996
Opioid and nonopioid swim stress-induced analgesia: a parametric analysis in mice.
    Physiology & behavior, 1996, Volume: 59, Issue:1

    Topics: Analgesia; Animals; Body Temperature; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Opioid Peptides; Pain Measurement; Stress, Psychological; Swimming

1996
Opioid antagonists and the sexual satiation phenomenon.
    Psychopharmacology, 1995, Volume: 122, Issue:2

    Topics: Animals; Copulation; Ejaculation; Male; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Satiety Response; Sexual Behavior, Animal

1995
The influence of opioid antagonists on the discriminative stimulus effects of ethanol.
    Pharmacology, biochemistry, and behavior, 1996, Volume: 54, Issue:4

    Topics: Animals; Discrimination, Psychological; Dose-Response Relationship, Drug; Ethanol; Male; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar

1996
Naltrindole sensitive delta 2 opioid receptor mediates invertebrate immunocyte activation.
    Acta biologica Hungarica, 1995, Volume: 46, Issue:2-4

    Topics: Animals; Bivalvia; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Humans; Immune System; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta

1995
Reductions in locomotor activity following central opioid receptor subtype antagonists in rats.
    Physiology & behavior, 1996, Volume: 60, Issue:3

    Topics: Animals; Enkephalins; Locomotion; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley

1996
Effects of the delta opioid against BW373U86 in pigeons trained to discriminate fentanyl, bremazocine and water in a three-choice drug discrimination procedure.
    Psychopharmacology, 1996, Volume: 126, Issue:3

    Topics: Analgesics; Animals; Benzamides; Benzomorphans; Columbidae; Discrimination, Psychological; Female; Fentanyl; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Piperazines; Receptors, Opioid, delta

1996
The NMDA receptor antagonist MK-801 differentially modulates mu and kappa opioid actions in spinal cord in vitro.
    Pain, 1996, Volume: 66, Issue:2-3

    Topics: Analgesics; Animals; Animals, Newborn; Benzeneacetamides; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; In Vitro Techniques; Membrane Potentials; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord

1996
Endogenous opioids acting at a medullary mu-opioid receptor contribute to the behavioral antinociception produced by GABA antagonism in the midbrain periaqueductal gray.
    Neuroscience, 1996, Volume: 74, Issue:3

    Topics: Animals; Bicuculline; Brain Mapping; GABA Antagonists; Male; Medulla Oblongata; Mesencephalon; Microinjections; Models, Neurological; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Somatostatin; Spinal Cord; Time Factors

1996
Effects of selective opioid receptor antagonists on morphine-induced changes in striatal and limbic dopamine metabolism.
    Pharmacology & toxicology, 1995, Volume: 77, Issue:3

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Dopamine; Homovanillic Acid; Injections, Intraperitoneal; Injections, Intraventricular; Limbic System; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pain Threshold; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu

1995
alpha-Adrenoceptor and opioid receptor modulation of clonidine-induced antinociception.
    British journal of pharmacology, 1996, Volume: 119, Issue:3

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Clonidine; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Injections, Intraventricular; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Prazosin; Receptors, Opioid; Yohimbine

1996
Rapid opiate detoxification.
    The American journal of drug and alcohol abuse, 1996, Volume: 22, Issue:4

    Topics: Adult; Anesthetics, Intravenous; Critical Care; Female; Heroin Dependence; Humans; Hypnotics and Sedatives; Length of Stay; Male; Middle Aged; Naloxone; Naltrexone; Narcotic Antagonists; Neuromuscular Nondepolarizing Agents; Propofol; Respiration, Artificial; Substance Withdrawal Syndrome; Time Factors; Treatment Outcome; Vecuronium Bromide

1996
Effects of the blockade of opioid receptor on defensive reactions elicited by electrical stimulation within the deep layers of the superior colliculus and DPAG.
    Brain research, 1996, Oct-14, Volume: 736, Issue:1-2

    Topics: Animals; Brain Mapping; Electric Stimulation; Escape Reaction; Male; Naloxone; Naltrexone; Narcotic Antagonists; Periaqueductal Gray; Rats; Rats, Wistar; Superior Colliculi

1996
kappa-opioid receptor expression defines a phenotypically distinct subpopulation of astroglia: relationship to Ca2+ mobilization, development, and the antiproliferative effect of opioids.
    Brain research, 1996, Oct-21, Volume: 737, Issue:1-2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Astrocytes; Benzeneacetamides; Bromodeoxyuridine; Calcium; Calcium Channel Blockers; Cell Count; Cell Division; Cells, Cultured; DNA; Enzyme Inhibitors; Gene Expression Regulation, Developmental; Immunohistochemistry; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Nifedipine; Phenotype; Pyrrolidines; Receptors, Opioid, kappa; Thapsigargin; Time Factors

1996
Opioid receptor-mediated control of acetylcholine release in human neocortex tissue.
    Naunyn-Schmiedeberg's archives of pharmacology, 1996, Volume: 354, Issue:5

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetylcholine; Adolescent; Adult; Aged; Analgesics; Analysis of Variance; Baclofen; Cerebral Cortex; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; GABA Agonists; Humans; Male; Middle Aged; Muscimol; Naloxone; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid, delta; Tetrodotoxin

1996
Role of opioid receptors (mu, delta 1, delta 2) in modulating responses of nociceptive neurons in the superficial and deeper dorsal horn of the medulla (trigeminal nucleus caudalis) in the rat.
    Brain research, 1996, Nov-11, Volume: 739, Issue:1-2

    Topics: Animals; Benzylidene Compounds; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Evoked Potentials; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nerve Fibers; Neurons; Nociceptors; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Trigeminal Caudal Nucleus

1996
Different central opioid receptor subtype antagonists modify maltose dextrin and deprivation-induced water intake in sham feeding and sham drinking rats.
    Brain research, 1996, Nov-25, Volume: 741, Issue:1-2

    Topics: Animals; Dose-Response Relationship, Drug; Drinking; Eating; Enkephalin, Leucine-2-Alanine; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Polysaccharides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Water Deprivation

1996
Neuropharmacological characterization of local ibogaine effects on dopamine release.
    Journal of neural transmission (Vienna, Austria : 1996), 1996, Volume: 103, Issue:8-9

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Dopamine; Dopamine Agents; Dose-Response Relationship, Drug; Ibogaine; Male; Microdialysis; Naloxone; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa

1996
Antidepressant-like effects of CCK(B) receptor antagonists: involvement of the opioid system.
    European journal of pharmacology, 1996, Dec-30, Volume: 318, Issue:2-3

    Topics: Animals; Antidepressive Agents; Benzodiazepinones; Devazepide; Disulfides; Endorphins; Male; Mice; Naloxone; Naltrexone; Phenylalanine; Phenylurea Compounds; Receptor, Cholecystokinin A; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Sincalide

1996
Reversal by kappa-agonists of peritoneal irritation-induced ileus and visceral pain in rats.
    Life sciences, 1997, Volume: 60, Issue:9

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetic Acid; Analgesics; Animals; Benzofurans; Benzomorphans; Cyclazocine; Fentanyl; Gastric Emptying; Intestinal Pseudo-Obstruction; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Peritoneum; Pyrroles; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Thiophenes

1997
Inhibition of the LH surge in cyclic rats by stress is not mediated by opioids.
    Life sciences, 1997, Volume: 60, Issue:10

    Topics: Animals; Female; Luteinizing Hormone; Naloxone; Naltrexone; Narcotic Antagonists; Opioid Peptides; Proestrus; Rats; Rats, Wistar; Restraint, Physical; Stress, Physiological

1997
Effects of mu-, delta- and kappa-opioid antagonists in atrial preparations from nonfailing and failing human hearts.
    General pharmacology, 1997, Volume: 28, Issue:3

    Topics: Adult; Aged; Depression, Chemical; Dose-Response Relationship, Drug; Female; Heart; Heart Atria; Heart Valve Diseases; Humans; In Vitro Techniques; Male; Middle Aged; Mitral Valve; Myocardial Contraction; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu

1997
Acute and chronic effects of opioids on delta and mu receptor activation of G proteins in NG108-15 and SK-N-SH cell membranes.
    Journal of neurochemistry, 1997, Volume: 68, Issue:4

    Topics: Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Glioma; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Hybrid Cells; Membrane Proteins; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Neuroblastoma; Protein Binding; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Signal Transduction; Sulfur Radioisotopes; Time Factors

1997
Nalbuphine coadministered with morphine prevents tolerance and dependence.
    Anesthesia and analgesia, 1997, Volume: 84, Issue:4

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Therapy, Combination; Drug Tolerance; Male; Morphine; Nalbuphine; Naloxone; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Pyrrolidines; Rats; Rats, Sprague-Dawley

1997
Opioid receptor antagonists attenuate heat stress-induced reduction in cerebral blood flow, increased blood-brain barrier permeability, vasogenic edema and cell changes in the rat.
    Annals of the New York Academy of Sciences, 1997, Mar-15, Volume: 813

    Topics: Animals; Blood-Brain Barrier; Body Temperature; Brain; Brain Edema; Cerebrovascular Circulation; Heat Stress Disorders; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar

1997
Modulation of neurotransmitter release by opioid mu- and kappa-receptors from adrenergic terminals in the myenteric plexus of the guinea-pig colon: effect of alpha 2-autoreceptor blockade.
    Neuroscience letters, 1997, Jan-31, Volume: 222, Issue:2

    Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics; Animals; Colon; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Myenteric Plexus; Naloxone; Naltrexone; Narcotic Antagonists; Neurotransmitter Agents; Norepinephrine; Pyrrolidines; Receptors, Adrenergic, alpha-2; Receptors, Opioid, kappa; Receptors, Opioid, mu; Yohimbine

1997
Actions of beta-endorphin peptides on the contractions of mouse diaphragm muscle.
    Peptides, 1997, Volume: 18, Issue:1

    Topics: Animals; Benzylidene Compounds; beta-Endorphin; Diaphragm; Dipeptides; Electric Stimulation; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Mice; Mice, Inbred C57BL; Muscle Contraction; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Neostigmine; Oligopeptides; Peptide Fragments

1997
Opioid growth factor is present in human and mouse gastrointestinal tract and inhibits DNA synthesis.
    The American journal of physiology, 1997, Volume: 272, Issue:4 Pt 2

    Topics: Animals; Cells, Cultured; Circadian Rhythm; DNA; DNA Replication; Enkephalin, Methionine; Esophagus; Gastric Mucosa; Growth Substances; Homeostasis; Humans; Intestinal Mucosa; Intestine, Large; Intestine, Small; Kinetics; Male; Mice; Mice, Inbred C57BL; Mitotic Index; Mucous Membrane; Naloxone; Naltrexone; Receptors, Opioid; Thymidine; Time Factors

1997
5-HT spinal antinociception involves mu opioid receptors: cross tolerance and antagonist studies.
    British journal of anaesthesia, 1997, Volume: 78, Issue:5

    Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Electric Stimulation; Hot Temperature; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pain Threshold; Rats; Rats, Wistar; Receptors, Opioid, mu; Serotonin; Serotonin Antagonists; Spinal Cord

1997
Antinociceptive effect of buprenorphine in mu1-opioid receptor deficient CXBK mice.
    Life sciences, 1997, Volume: 60, Issue:22

    Topics: Animals; Buprenorphine; Male; Mice; Mice, Inbred C57BL; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu; Species Specificity

1997
Effect of prior nicotine treatment on drug induced changes in serum LH concentrations in rats.
    Life sciences, 1997, Volume: 60, Issue:25

    Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Dopamine Antagonists; Drug Administration Schedule; Drug Interactions; Gonadotropin-Releasing Hormone; Haloperidol; Luteinizing Hormone; Male; Naloxone; Naltrexone; Narcotic Antagonists; Neurotransmitter Agents; Nicotine; Nicotinic Agonists; Rats; Rats, Sprague-Dawley; Stimulation, Chemical

1997
Antinociceptive and immunosuppressive effects of opiate drugs: a structure-related activity study.
    British journal of pharmacology, 1997, Volume: 121, Issue:4

    Topics: Animals; Cell Division; Codeine; Hydromorphone; Immune System; Immunosuppression Therapy; Interleukin-2; Male; Mice; Morphine; Nalorphine; Naloxone; Naltrexone; Narcotics; Oxycodone; Structure-Activity Relationship

1997
Extraordinary potency of a novel delta opioid receptor agonist is due in part to increased efficacy.
    Life sciences, 1997, Volume: 61, Issue:2

    Topics: Animals; Biological Assay; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Narcotic Antagonists; Peptides; Peptides, Cyclic; Receptors, Opioid, delta; Vas Deferens

1997
Participation of central kappa-opioid receptor in arrhythmogenesis.
    Life sciences, 1997, Volume: 61, Issue:3

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Arrhythmias, Cardiac; Dynorphins; Epinephrine; Hexamethonium; Male; Naloxone; Naltrexone; Narcotic Antagonists; Peptide Fragments; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, kappa

1997
Effects of kappa opioids on cocaine self-administration by rhesus monkeys.
    The Journal of pharmacology and experimental therapeutics, 1997, Volume: 282, Issue:1

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Circadian Rhythm; Cocaine; Dose-Response Relationship, Drug; Ethylketocyclazocine; Female; Macaca mulatta; Male; Naloxone; Naltrexone; Pyrrolidines; Receptors, Opioid, kappa; Self Administration; Substance-Related Disorders

1997
In vivo binding of [125I]NH2-carfentanil to mu opioid receptors in mouse brain.
    Nuclear medicine and biology, 1994, Volume: 21, Issue:2

    Topics: Animals; Autoradiography; Brain; Fentanyl; Injections, Intraperitoneal; Iodine Radioisotopes; Logistic Models; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Radioligand Assay; Receptors, Opioid, mu

1994
Involvement of opioid mu 1 receptors in morphine-induced conditioned place preference in rats.
    Pharmacology, biochemistry, and behavior, 1997, Volume: 58, Issue:1

    Topics: Analgesics, Opioid; Animals; Body Temperature; Catalepsy; Conditioning, Operant; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Rats; Rats, Wistar; Receptors, Opioid, mu

1997
[Central K1-opiate receptors and mechanisms of arrhythmogenesis].
    Biulleten' eksperimental'noi biologii i meditsiny, 1997, Volume: 123, Issue:6

    Topics: Animals; Arrhythmias, Cardiac; Blood-Brain Barrier; Brain; Dynorphins; Ganglionic Blockers; Heart; Hexamethonium; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Parasympathetic Nervous System; Rats; Rats, Wistar; Receptors, Opioid, kappa

1997
Brain and spinal cord distribution of biphalin: correlation with opioid receptor density and mechanism of CNS entry.
    Journal of neurochemistry, 1997, Volume: 69, Issue:3

    Topics: Analgesics; Animals; Binding, Competitive; Brain; Enkephalins; Iodine Radioisotopes; Kinetics; Models, Chemical; Naloxone; Naltrexone; Narcotic Antagonists; Organ Specificity; Peptides; Radioisotope Dilution Technique; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord; Tissue Distribution

1997
Food intake and food choice: the role of the endogenous opioid peptides in the marsupial Sminthopsis crassicaudata.
    Brain research, 1997, Aug-01, Volume: 764, Issue:1-2

    Topics: Animals; Diet; Eating; Endorphins; Energy Intake; Food Preferences; Male; Marsupialia; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu

1997
Prejunctional modulation by nociceptin of nerve-mediated inotropic responses in guinea-pig left atrium.
    European journal of pharmacology, 1997, Aug-13, Volume: 332, Issue:3

    Topics: Animals; Atrial Function; Calcitonin Gene-Related Peptide; Capsaicin; Electric Stimulation; Guinea Pigs; Heart Atria; In Vitro Techniques; Male; Myocardial Contraction; Naloxone; Naltrexone; Neuromuscular Junction; Neurons, Afferent; Nociceptin; Opioid Peptides; Sensory Receptor Cells

1997
Naltrindole, a selective delta-opioid receptor antagonist, potentiates the lethal effects of cocaine by a central mechanism of action.
    European journal of pharmacology, 1997, Aug-20, Volume: 333, Issue:1

    Topics: Animals; Blood Pressure; Central Nervous System; Cisterna Magna; Cocaine; Drug Synergism; Heart Rate; Infusions, Intravenous; Injections; Male; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Seizures

1997
The possible role of protein phosphatase 2A in the sodium sensitivity of the receptor binding of opiate antagonists naloxone and naltrindole.
    Brain research bulletin, 1997, Volume: 44, Issue:3

    Topics: Animals; Corpus Striatum; Enzyme Activation; Enzyme Inhibitors; Male; Marine Toxins; Naloxone; Naltrexone; Narcotic Antagonists; Oxazoles; Phosphoprotein Phosphatases; Phosphorus Radioisotopes; Phosphorylase a; Protein Phosphatase 1; Protein Phosphatase 2; Rats; Rats, Wistar; Receptors, Opioid; Sensitivity and Specificity; Sodium Chloride; Substrate Specificity; Tritium

1997
Antinociceptive effects of morphine and U-50,488H on vaginal distension in the anesthetized rat.
    Life sciences, 1997, Volume: 61, Issue:16

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia; Animals; Blood Pressure; Cardiovascular System; Estrus; Female; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vaginal Diseases

1997
The effect of opioid antagonists in local regulation of testicular response to acute stress in adult rats.
    Steroids, 1997, Volume: 62, Issue:11

    Topics: 3-Hydroxysteroid Dehydrogenases; Animals; Injections; Male; Naloxone; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Rats; Rats, Wistar; Restraint, Physical; Stress, Physiological; Testis; Testosterone

1997
Anatomical distribution of mu, delta, and kappa opioid- and nociceptin/orphanin FQ-stimulated [35S]guanylyl-5'-O-(gamma-thio)-triphosphate binding in guinea pig brain.
    The Journal of comparative neurology, 1997, Oct-06, Volume: 386, Issue:4

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Non-Narcotic; Animals; Autoradiography; Brain Chemistry; Cerebellum; Diencephalon; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Male; Medulla Oblongata; Mesencephalon; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptin; Opioid Peptides; Pons; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sulfur Radioisotopes; Telencephalon

1997
Conditioned immunomodulation: investigations of the role of endogenous activity at mu, kappa, and delta opioid receptor subtypes.
    Journal of neuroimmunology, 1997, Volume: 79, Issue:2

    Topics: Animals; Avoidance Learning; Cell Division; Conditioning, Classical; Electroshock; Immune System; Killer Cells, Natural; Lipopolysaccharides; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Lew; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spleen

1997
Discriminative stimulus effects of the mixed-opioid agonist/antagonist dezocine: cross-substitution by mu and delta opioid agonists.
    The Journal of pharmacology and experimental therapeutics, 1997, Volume: 283, Issue:3

    Topics: Analgesics, Opioid; Animals; Bridged Bicyclo Compounds, Heterocyclic; Columbidae; Cycloparaffins; Discrimination Learning; Female; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Receptors, Opioid, mu; Tetrahydronaphthalenes

1997
Kappa-opioid restraint of oxytocin secretion: plasticity through pregnancy.
    Neuroendocrinology, 1997, Volume: 66, Issue:6

    Topics: Animals; Basal Metabolism; Cholecystokinin; Female; Naloxone; Naltrexone; Oxytocin; Pregnancy; Pregnancy, Animal; Rats; Rats, Wistar; Receptors, Opioid, kappa; Receptors, Opioid, mu; Secretory Rate

1997
Characterization of opiate binding sites on the goldfish (Carassius auratus L.) pronephric leukocytes.
    Polish journal of pharmacology, 1997, Volume: 49, Issue:4

    Topics: Animals; Binding Sites; Goldfish; Leukocytes; Morphinans; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Receptors, Opioid, mu

1997
Opioid receptor-mediated inhibition of omega-conotoxin GVIA-sensitive calcium channel currents in rat intracardiac neurons.
    Journal of neurophysiology, 1998, Volume: 79, Issue:2

    Topics: Acetylcholine; Animals; Animals, Newborn; Anti-Arrhythmia Agents; Benzomorphans; Calcium; Calcium Channels; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Heart Conduction System; Ion Channel Gating; Ion Transport; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; omega-Conotoxin GVIA; Parasympathetic Nervous System; Patch-Clamp Techniques; Peptides; Pertussis Toxin; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Virulence Factors, Bordetella

1998
Morphine-6-glucuronide-induced locomotor stimulation in mice: role of opioid receptors.
    Pharmacology & toxicology, 1998, Volume: 82, Issue:1

    Topics: Analgesics, Opioid; Analysis of Variance; Animals; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred C57BL; Morphine; Morphine Derivatives; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid

1998
Identification of opioid receptor subtypes in antinociceptive actions of supraspinally-administered mitragynine in mice.
    Life sciences, 1998, Volume: 62, Issue:16

    Topics: Analgesics; Animals; Drug Synergism; Injections, Intraventricular; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Pain Measurement; Receptors, Opioid; Receptors, Opioid, mu; Secologanin Tryptamine Alkaloids

1998
Supraspinal flumazenil inhibits the antianalgesic action of spinal dynorphin A (1-17).
    Pharmacology, biochemistry, and behavior, 1998, Volume: 60, Issue:1

    Topics: Analgesia; Analgesics; Animals; Clonidine; Dose-Response Relationship, Drug; Drug Interactions; Dynorphins; Flumazenil; GABA Agonists; GABA-A Receptor Agonists; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Naltrexone; Physostigmine

1998
Clinical experience with antagonist-induced opiate withdrawal under anaesthesia.
    Addiction (Abingdon, England), 1998, Volume: 93, Issue:2

    Topics: Anesthesia; Hospitalization; Humans; Inactivation, Metabolic; Naloxone; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders

1998
Rapid opioid detoxification.
    JAMA, 1998, Jun-17, Volume: 279, Issue:23

    Topics: Adult; Drug Implants; Fentanyl; Humans; Male; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders

1998
Dynorphin uses a non-opioid mechanism to potentiate N-methyl-D-aspartate currents in single rat periaqueductal gray neurons.
    Neuroscience letters, 1998, May-15, Volume: 247, Issue:2-3

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Action Potentials; Analgesics, Non-Narcotic; Animals; Drug Synergism; Dynorphins; N-Methylaspartate; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Patch-Clamp Techniques; Peptide Fragments; Periaqueductal Gray; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa

1998
Beta-funaltrexamine discriminates between two subtypes of mu2-opioid receptors in electrically stimulated longitudinal muscle of guinea pig ileum.
    General pharmacology, 1998, Volume: 31, Issue:2

    Topics: Acetylcholine; Animals; Binding, Competitive; Electric Stimulation; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists; Nerve Endings; Receptors, Opioid, mu; Tetrodotoxin

1998
The involvement of the opioidergic system in the antinociceptive mechanism of action of antidepressant compounds.
    British journal of pharmacology, 1998, Volume: 124, Issue:4

    Topics: Abdominal Muscles; Acetic Acid; Amitriptyline; Analgesics; Animals; Antidepressive Agents; Cyclobutanes; Dothiepin; Male; Maprotiline; Mice; Muscle Contraction; Naloxone; Naltrexone; Narcotic Antagonists; Neprilysin; Neurotransmitter Uptake Inhibitors; Opioid Peptides; Pain Measurement; Paroxetine; Protease Inhibitors; Receptors, Opioid; Selective Serotonin Reuptake Inhibitors; Thiorphan

1998
Affinity profiles of novel delta-receptor selective benzofuran derivatives of non-peptide opioids.
    Neurochemical research, 1998, Volume: 23, Issue:9

    Topics: Animals; Benzeneacetamides; Benzofurans; Binding, Competitive; Brain; Cell Membrane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Naloxone; Naltrexone; Oligopeptides; Oxycodone; Oxymorphone; Pyrrolidines; Radioligand Assay; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Tritium

1998
Rapid opioid detoxification under anaesthesia.
    Hospital medicine (London, England : 1998), 1998, Volume: 59, Issue:3

    Topics: Adult; Anesthesia, General; Atracurium; Drug Therapy, Combination; Follow-Up Studies; Gastrointestinal Agents; Humans; Hypnotics and Sedatives; Male; Midazolam; Naloxone; Naltrexone; Narcotic Antagonists; Nicotinic Antagonists; Octreotide; Opioid-Related Disorders; Propofol

1998
Involvement of mu- and delta-opioid receptors in the ethanol-associated place preference in rats exposed to foot shock stress.
    Brain research, 1998, Aug-24, Volume: 803, Issue:1-2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Ethanol; Exploratory Behavior; Foot; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Morphine; Naloxone; Naltrexone; Narcotics; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu

1998
Orphanin FQ/nociceptin inhibits synaptic transmission and long-term potentiation in rat dentate gyrus through postsynaptic mechanisms.
    Journal of neurophysiology, 1998, Volume: 80, Issue:3

    Topics: Action Potentials; Animals; Dentate Gyrus; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Long-Term Potentiation; Male; N-Methylaspartate; Naloxone; Naltrexone; Narcotic Antagonists; Neural Inhibition; Nociceptin; Opioid Peptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Synapses; Synaptic Transmission; Tetrodotoxin

1998
Sex differences in opioid and N-methyl-D-aspartate mediated non-opioid biting fly exposure induced analgesia in deer mice.
    Pain, 1998, Volume: 77, Issue:2

    Topics: Amino Acids; Analgesia; Analysis of Variance; Animals; Behavior, Animal; Excitatory Amino Acid Antagonists; Female; Houseflies; Insect Bites and Stings; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Peromyscus; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa; Sex Characteristics; Stress, Physiological

1998
kappa-opioid regulation of neuronal activity in the rat supraoptic nucleus in vivo.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998, Nov-15, Volume: 18, Issue:22

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Cells, Cultured; Dendrites; Down-Regulation; Dynorphins; Electrophysiology; Female; Injections, Intravenous; Membrane Potentials; Microdialysis; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Oxytocin; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Supraoptic Nucleus; Vasopressins

1998
Nalmefene causes greater hypothalamic-pituitary-adrenal axis activation than naloxone in normal volunteers: implications for the treatment of alcoholism.
    Alcoholism, clinical and experimental research, 1998, Volume: 22, Issue:7

    Topics: Adrenocorticotropic Hormone; Adult; Aged; Alcoholism; Female; Humans; Hydrocortisone; Hypothalamo-Hypophyseal System; Infusions, Intravenous; Male; Middle Aged; Naloxone; Naltrexone; Narcotic Antagonists; Pituitary-Adrenal System; Treatment Outcome

1998
The effect of pentylenetetrazol kindling on synaptic mechanisms of interacting glutamatergic and opioid system in the hippocampus of rats.
    Brain research, 1998, Nov-16, Volume: 811, Issue:1-2

    Topics: Animals; Convulsants; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hippocampus; In Vitro Techniques; Kindling, Neurologic; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pentylenetetrazole; Rats; Rats, Wistar; Receptors, Glutamate; Receptors, Opioid; Seizures; Synapses

1998
Opioid involvement in behavior modifications of mice infected with the parasitic nematode, Nippostrongylus brasiliensis.
    Life sciences, 1998, Volume: 63, Issue:18

    Topics: Animals; Behavior, Animal; Injections, Intraperitoneal; Male; Mice; Mice, Inbred ICR; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Nippostrongylus; Reaction Time; Receptors, Opioid; Receptors, Opioid, mu; Receptors, sigma; Strongylida Infections

1998
Ameliorative effects of tachykinins on scopolamine-induced impairment of spontaneous alternation performance in mice.
    Methods and findings in experimental and clinical pharmacology, 1998, Volume: 20, Issue:7

    Topics: Animals; Male; Mice; Muscarinic Antagonists; Naloxone; Naltrexone; Narcotic Antagonists; Neurokinin A; Peptide Fragments; Psychomotor Performance; Scopolamine; Substance P; Tachykinins

1998
Time window for the contribution of the delta-opioid receptor to cardioprotection by ischemic preconditioning in the rat heart.
    Cardiovascular drugs and therapy, 1998, Volume: 12, Issue:4

    Topics: Animals; Heart; Ischemic Preconditioning, Myocardial; Male; Myocardial Infarction; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Time Factors

1998
Opioid efficacy in a C6 glioma cell line stably expressing the human kappa opioid receptor.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 288, Issue:2

    Topics: Analgesics, Opioid; Animals; Benzeneacetamides; Glioma; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Ligands; Naloxone; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rats; Receptors, Opioid, kappa; Stereoisomerism; Transfection; Tritium; Tumor Cells, Cultured

1999
Heroin antinociception changed from mu to delta receptor in streptozotocin-treated mice.
    Japanese journal of pharmacology, 1998, Volume: 78, Issue:4

    Topics: Analgesics, Opioid; Animals; Anti-Bacterial Agents; Benzylidene Compounds; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Heroin; Injections, Intraventricular; Male; Mice; Morphine; Morphine Derivatives; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Pain; Receptors, Opioid, delta; Receptors, Opioid, mu; Streptozocin; Time Factors

1998
Effects of peptidase inhibitors on the enkephalin-induced anti-nociception in rats.
    Japanese journal of pharmacology, 1998, Volume: 78, Issue:4

    Topics: Animals; Anti-Bacterial Agents; Area Under Curve; Captopril; Dose-Response Relationship, Drug; Drug Therapy, Combination; Enkephalin, Methionine; Glycopeptides; Injections, Intraventricular; Injections, Subcutaneous; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Pain; Pain Measurement; Peptides; Protease Inhibitors; Rats; Rats, Wistar

1998
The involvement of opioidergic and noradrenergic mechanisms in nefopam antinociception.
    European journal of pharmacology, 1999, Jan-22, Volume: 365, Issue:2-3

    Topics: Abdominal Pain; Acetic Acid; Adrenergic alpha-Antagonists; Analgesics; Analgesics, Non-Narcotic; Animals; Clonidine; Dose-Response Relationship, Drug; Drug Interactions; Idazoxan; Injections, Intraventricular; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Nefopam; Pain Measurement; Receptors, Adrenergic; Receptors, Opioid

1999
Opioid peptide pharmacology and immunocytochemistry in an animal model of self-sustaining status epilepticus.
    Neuroscience, 1999, Volume: 89, Issue:1

    Topics: Action Potentials; Analgesics; Analgesics, Opioid; Animals; Disease Models, Animal; Dynorphins; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Immunohistochemistry; Male; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Opioid Peptides; Peptide Fragments; Perforant Pathway; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Status Epilepticus

1999
Dynorphin A increases substance P release from trigeminal primary afferent C-fibers.
    European journal of pharmacology, 1999, Jan-29, Volume: 366, Issue:1

    Topics: Animals; Animals, Newborn; Capsaicin; Dizocilpine Maleate; Dynorphins; Enkephalin, Leucine; Excitatory Amino Acid Antagonists; In Vitro Techniques; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nerve Fibers; Neurons, Afferent; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Substance P; Trigeminal Nuclei

1999
Different roles of mu-, delta- and kappa-opioid receptors in ethanol-associated place preference in rats exposed to conditioned fear stress.
    European journal of pharmacology, 1999, Feb-26, Volume: 368, Issue:1

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Behavior, Animal; Central Nervous System Depressants; Conditioning, Psychological; Ethanol; Fear; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stress, Psychological

1999
[A molecular mechanism for supersensitization of adenylyl cyclase system in cloned opioid receptor-transfected cells following sustained opioid treatment].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1998, Volume: 112 Suppl 1

    Topics: Adenylyl Cyclases; Analgesics; Animals; Atropine; Benzeneacetamides; Carbachol; CHO Cells; Clone Cells; Cricetinae; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP Phosphohydrolases; Morphine; Muscarinic Agonists; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Transfection

1998
Opioidergic modulation of voltage-activated K+ currents in magnocellular neurons of the supraoptic nucleus in rat.
    Journal of neurophysiology, 1999, Volume: 81, Issue:4

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Ion Channel Gating; Membrane Potentials; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Patch-Clamp Techniques; Potassium Channels; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Supraoptic Nucleus

1999
Spinal blockade of opioid receptors prevents the analgesia produced by TENS in arthritic rats.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 289, Issue:2

    Topics: Animals; Arthritis; Behavior, Animal; Carrageenan; Injections, Intra-Articular; Kaolin; Male; Microdialysis; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord; Transcutaneous Electric Nerve Stimulation

1999
Evaluation of hypothermia-induced analgesia and influence of opioid antagonists in leopard frogs (Rana pipiens).
    Pharmacology, biochemistry, and behavior, 1999, Volume: 63, Issue:1

    Topics: Analgesia; Analgesics, Opioid; Animals; Evaluation Studies as Topic; Hypothermia, Induced; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rana pipiens

1999
Differential involvement of mu-opioid receptor subtypes in endomorphin-1- and -2-induced antinociception.
    European journal of pharmacology, 1999, May-07, Volume: 372, Issue:1

    Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intraventricular; Injections, Spinal; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Oligopeptides; Pain; Receptors, Opioid, mu; Time Factors

1999
Direct preconditioning of cardiac myocytes via opioid receptors and KATP channels.
    Circulation research, 1999, Jun-25, Volume: 84, Issue:12

    Topics: Adenosine Triphosphate; Analgesics, Opioid; Animals; Anti-Arrhythmia Agents; Benzylidene Compounds; Cells, Cultured; Chick Embryo; Decanoic Acids; Hydroxy Acids; Ischemic Preconditioning, Myocardial; Morphine; Muscle Fibers, Skeletal; Myocardium; Naloxone; Naltrexone; Narcotic Antagonists; Potassium Channels; Receptors, Opioid

1999
The discriminative stimulus effects of naloxone and naltrexone in morphine-treated rhesus monkeys: comparison of oral and subcutaneous administration.
    Psychopharmacology, 1999, Volume: 144, Issue:2

    Topics: Animals; Discrimination Learning; Female; Macaca mulatta; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics

1999
Supersensitization of the adenylyl cyclase system in Chinese hamster ovary cells co-expressing cloned opioid receptors and Gz, a PTX-insensitive G protein.
    Neuroscience letters, 1999, May-28, Volume: 267, Issue:2

    Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Benzeneacetamides; CHO Cells; Cricetinae; Cyclic AMP; Enzyme Activation; Female; GTP-Binding Protein alpha Subunits; Heterotrimeric GTP-Binding Proteins; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pertussis Toxin; Pyrrolidines; Receptors, Opioid; Virulence Factors, Bordetella

1999
Naloxone blocks endomorphin-1 but not endomorphin-2 induced inhibition of tachykinergic contractions of guinea-pig isolated bronchus.
    British journal of pharmacology, 1999, Volume: 127, Issue:3

    Topics: Analgesics, Opioid; Animals; Bronchi; Capsaicin; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Naloxone; Naltrexone; Narcotic Antagonists; Neurokinin A; Oligopeptides; Receptors, Opioid, mu; Tachykinins

1999
Ligands for opioid and sigma-receptors improve cardiac electrical stability in rat models of post-infarction cardiosclerosis and stress.
    Life sciences, 1999, Volume: 65, Issue:1

    Topics: Animals; Anti-Arrhythmia Agents; beta-Endorphin; Disease Models, Animal; Dynorphins; Enkephalin, Leucine-2-Alanine; Heart; Immobilization; Ligands; Morphine; Myocardial Infarction; Myocardium; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Piperidines; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, delta; Stress, Physiological; Ventricular Fibrillation

1999
Irreversible labelling of the opioid receptors by a melphalan-substituted [Met5]enkephalin-Arg-Phe derivative.
    European journal of pharmacology, 1999, Jun-04, Volume: 373, Issue:2-3

    Topics: Affinity Labels; Amino Acid Sequence; Amino Acid Substitution; Animals; Binding Sites; Binding, Competitive; Brain; Enkephalin, Methionine; Female; Guinea Pigs; Male; Melphalan; Membranes; Naloxone; Naltrexone; Narcotic Antagonists; Radioligand Assay; Rats; Receptors, Opioid

1999
The bed nucleus of the stria terminalis. A target site for noradrenergic actions in opiate withdrawal.
    Annals of the New York Academy of Sciences, 1999, Jun-29, Volume: 877

    Topics: Amygdala; Animals; Axonal Transport; Caudate Nucleus; Male; Microinjections; Morphine Dependence; Naloxone; Naltrexone; Neurons; Norepinephrine; Oxidopamine; Propranolol; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Thalamus; Tyrosine 3-Monooxygenase

1999
Paradoxical effects of intracerebroventricular low-dose opioid antagonists in SHR with chronic pain.
    Life sciences, 1999, Volume: 65, Issue:4

    Topics: Analgesia; Animals; Arteries; Blood Pressure; Body Temperature; Body Weight; Brain; Chronic Disease; Hypertension; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Pain Threshold; Quaternary Ammonium Compounds; Rats; Rats, Inbred SHR; Rats, Inbred WKY

1999
Modulation of emesis by fentanyl and opioid receptor antagonists in Suncus murinus (house musk shrew).
    European journal of pharmacology, 1999, Jun-11, Volume: 374, Issue:1

    Topics: Animals; Antiemetics; Female; Fentanyl; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nicotine; Receptors, Opioid; Shrews; Vomiting

1999
Interactions between cholecystokinin and opioids in the isolated guinea-pig ileum.
    British journal of pharmacology, 1999, Volume: 127, Issue:4

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphinans; Muscle Contraction; Naloxone; Naltrexone; Oligopeptides; Opioid Peptides; Receptor, Cholecystokinin A; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Receptors, Opioid; Sincalide; Substance Withdrawal Syndrome

1999
Effects of diethylstilbestrol on mouse hippocampal evoked potentials in vitro.
    Cellular and molecular neurobiology, 1999, Volume: 19, Issue:6

    Topics: Animals; Binding, Competitive; Dactinomycin; Diethylstilbestrol; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Estrogens; Excitatory Postsynaptic Potentials; Hippocampus; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Nerve Tissue Proteins; Pyramidal Cells; Receptors, Opioid; Receptors, Opioid, mu

1999
Effects of opiate antagonist treatment on the alcohol deprivation effect in long-term ethanol-experienced rats.
    Psychopharmacology, 1999, Volume: 145, Issue:4

    Topics: Alcoholism; Animals; Ethanol; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Self Administration

1999
Endomorphin-1 and endomorphin-2, endogenous ligands for the mu-opioid receptor, inhibit electrical activity of rat rostral ventrolateral medulla neurons in vitro.
    Neuroscience, 1999, Volume: 93, Issue:2

    Topics: Animals; Electrophysiology; Enkephalin, Methionine; In Vitro Techniques; Ligands; Male; Medulla Oblongata; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Nociceptin; Oligopeptides; Opioid Peptides; Perfusion; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu

1999
Antinociceptive properties of FR140423 mediated through spinal delta-, but not mu- and kappa-, opioid receptors.
    European journal of pharmacology, 1999, Sep-10, Volume: 380, Issue:2-3

    Topics: Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Binding, Competitive; Diarrhea; Injections, Intraventricular; Injections, Spinal; Male; Membranes; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Pyrazoles; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord; Sulfoxides

1999
Nalmefene. JF 1, nalmetrene, NIH 10365, ORF 11676, Arthrene, Cervene, Incystene, Revex.
    Drugs in R&D, 1999, Volume: 1, Issue:1

    Topics: Animals; Drug Overdose; Drugs, Investigational; Humans; Male; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Rabbits; Stroke

1999
The delta 2-opioid receptor antagonist naltriben reduces motivated responding for ethanol.
    Psychopharmacology, 1999, Volume: 147, Issue:1

    Topics: Alcohol Deterrents; Alcohol Drinking; Animals; Central Nervous System Depressants; Conditioning, Operant; Ethanol; Female; Motivation; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid, delta; Reinforcement Schedule

1999
Dynorphin A (1-13) neurotoxicity in vitro: opioid and non-opioid mechanisms in mouse spinal cord neurons.
    Experimental neurology, 1999, Volume: 160, Issue:2

    Topics: Analgesics, Opioid; Animals; Calcium; Cell Survival; Dizocilpine Maleate; Dynorphins; Embryo, Mammalian; Kynurenic Acid; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Neurotoxins; Peptide Fragments; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Valine

1999
Is there a pharmacological basis for therapy with rapid opioid detoxification?
    Lancet (London, England), 1999, Dec-11, Volume: 354, Issue:9195

    Topics: Anesthesia, General; Animals; Conscious Sedation; Cyclic AMP Response Element-Binding Protein; Heroin Dependence; Humans; Mice; Mice, Knockout; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu; Signal Transduction; Substance Withdrawal Syndrome; Treatment Outcome

1999
Dynorphin A enhances mitogen-induced proliferative response and interleukin-2 production of rat splenocytes.
    Neuropeptides, 1999, Volume: 33, Issue:2

    Topics: Analgesics, Opioid; Animals; Cells, Cultured; Concanavalin A; Dynorphins; Interleukin-2; Lymphocyte Activation; Lymphocytes; Male; Naloxone; Naltrexone; Narcotic Antagonists; Peptide Fragments; Rats; Rats, Sprague-Dawley; Spleen

1999
An interaction of opioids and galanin in dorsal horn of the spinal cord in mononeuropathic rats.
    Regulatory peptides, 2000, Jan-29, Volume: 86, Issue:1-3

    Topics: Animals; Galanin; Hindlimb; Injections, Spinal; Male; Mononeuropathies; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pain Measurement; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Spinal Cord

2000
Analgesic effect of interferon-alpha via mu opioid receptor in the rat.
    Neurochemistry international, 2000, Volume: 36, Issue:3

    Topics: Analgesia; Animals; Antibodies, Monoclonal; Cell Line; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Leucine; Injections, Intraventricular; Interferon Type I; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Recombinant Proteins

2000
Acute delta-opioid receptor activation induces CREB phosphorylation in NG108-15 cells.
    European journal of pharmacology, 2000, Feb-25, Volume: 390, Issue:1-2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Analgesics, Opioid; Blotting, Western; Calmodulin; Cell Line; Cyclic AMP Response Element-Binding Protein; Enkephalin, D-Penicillamine (2,5)-; Enzyme Inhibitors; Humans; Isoquinolines; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Phosphorylation; Protein Kinase C; Protein Synthesis Inhibitors; Receptors, Opioid, delta; Time Factors

2000
The antinociceptive effects of endomorphin-1 and endomorphin-2 in diabetic mice.
    European journal of pharmacology, 2000, Mar-10, Volume: 391, Issue:1-2

    Topics: Analgesics, Opioid; Animals; Diabetes Mellitus, Experimental; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Oligopeptides; Pain Measurement; Reaction Time; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu

2000
Activation of c-fos expression in hypothalamic nuclei by mu- and kappa-receptor agonists: correlation with catecholaminergic activity in the hypothalamic paraventricular nucleus.
    Endocrinology, 2000, Volume: 141, Issue:4

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Male; Methoxyhydroxyphenylglycol; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Norepinephrine; Paraventricular Hypothalamic Nucleus; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Suprachiasmatic Nucleus; Supraoptic Nucleus

2000
Inhibitory effect of intracerebroventricularly-administered [D-Arg(2), beta-Ala(4)]-dermorphin (1-4) on gastrointestinal transit.
    Peptides, 2000, Volume: 21, Issue:2

    Topics: Analgesics; Animals; Charcoal; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Female; Gastrointestinal Transit; Injections, Intraventricular; Mice; Mice, Inbred Strains; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides

2000
Selective antagonism by naloxonazine of antinociception by Tyr-D-Arg-Phe-beta-Ala, a novel dermorphin analogue with high affinity at mu-opioid receptors.
    European journal of pharmacology, 2000, Apr-28, Volume: 395, Issue:2

    Topics: Analgesics; Analgesics, Opioid; Animals; Drug Antagonism; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Injections, Intraventricular; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Opioid Peptides; Pain Measurement; Receptors, Opioid, mu; Time Factors

2000
Improvement by low doses of nociceptin on scopolamine-induced impairment of learning and/or memory.
    European journal of pharmacology, 2000, Apr-28, Volume: 395, Issue:2

    Topics: Analgesics, Opioid; Animals; Avoidance Learning; Disease Models, Animal; Dizocilpine Maleate; Learning Disabilities; Male; Maze Learning; Memory Disorders; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Neuroprotective Agents; Nociceptin; Opioid Peptides; Psychomotor Performance; Rats; Scopolamine

2000
Mercaptoacetate induces feeding through central opioid-mediated mechanisms in rats.
    Brain research, 2000, May-12, Volume: 864, Issue:2

    Topics: Animals; Antisense Elements (Genetics); Cloning, Molecular; Eating; Exons; Feeding Behavior; Injections, Intraperitoneal; Injections, Intraventricular; Locomotion; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stereotyped Behavior; Thioglycolates

2000
Naloxone antagonizes GABA(A)/benzodiazepine receptor function in rat corticohippocampal synaptoneurosomes.
    Journal of neural transmission (Vienna, Austria : 1996), 2000, Volume: 107, Issue:3

    Topics: Amobarbital; Animals; Cerebral Cortex; Chlorine; GABA Modulators; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hippocampus; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Neurons; Radioisotopes; Rats; Rats, Sprague-Dawley; Synaptosomes

2000
Functional evidence that gastroprotection can be induced by activation of central alpha(2B)-adrenoceptor subtypes in the rat.
    European journal of pharmacology, 2000, May-19, Volume: 396, Issue:2-3

    Topics: Adrenergic alpha-Agonists; Animals; Brain; Clonidine; Enkephalin, Leucine-2-Alanine; Gastric Mucosa; Injections, Intraventricular; Male; Naloxone; Naltrexone; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2

2000
Mice deficient for delta- and mu-opioid receptors exhibit opposing alterations of emotional responses.
    Nature genetics, 2000, Volume: 25, Issue:2

    Topics: Animals; Anxiety; Binding Sites; Darkness; Depression; Electroshock; Female; Gene Deletion; Light; Male; Mice; Mice, Knockout; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Pain Threshold; Phenotype; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sex Characteristics; Swimming

2000
The effects of highly selective opioid receptor antagonists on the release of arginine vasotocin induced by hyperosmotic stimulation and angiotensin II injection.
    General and comparative endocrinology, 2000, Volume: 118, Issue:3

    Topics: Angiotensin II; Animals; Chickens; Male; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Saline Solution, Hypertonic; Vasotocin

2000
Selective opioid receptor agonist and antagonist displacement of [3H]naloxone binding in amphibian brain.
    European journal of pharmacology, 2000, Jun-02, Volume: 397, Issue:2-3

    Topics: Animals; Binding, Competitive; Brain; Dose-Response Relationship, Drug; Kinetics; Naloxone; Naltrexone; Narcotic Antagonists; Radioligand Assay; Rana pipiens; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tritium

2000
Altered opioid-mediated control of the spinal release of dynorphin and met-enkephalin in polyarthritic rats.
    Synapse (New York, N.Y.), 2000, Sep-15, Volume: 37, Issue:4

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia; Animals; Arthritis; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Iodine Radioisotopes; Ligands; Male; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord

2000
Receptor selectivity of Met-enkephalin-Arg6-Phe7, an endogenous opioid peptide, in cerebral cortex of human and rat.
    Life sciences, 2000, May-26, Volume: 67, Issue:1

    Topics: Adult; Animals; Benzeneacetamides; Benzomorphans; Binding Sites; Cerebral Cortex; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Ethylketocyclazocine; Female; Humans; Male; Naloxone; Naltrexone; Norepinephrine; Oligopeptides; Peptide Fragments; Peptides; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Somatostatin

2000
Managing constipation that's opioid-induced.
    RN, 2000, Volume: 63, Issue:6

    Topics: Administration, Oral; Adult; Analgesics, Opioid; Breast Neoplasms; Chemistry, Pharmaceutical; Constipation; Female; Humans; Methadone; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Quaternary Ammonium Compounds

2000
Calmodulin regulation of basal and agonist-stimulated G protein coupling by the mu-opioid receptor (OP(3)) in morphine-pretreated cell.
    Journal of neurochemistry, 2000, Volume: 75, Issue:2

    Topics: Amino Acid Substitution; Animals; Calmodulin; Cell Line; Cell Membrane; Chickens; Egtazic Acid; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Kidney; Kinetics; Morphine; Mutagenesis, Site-Directed; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu; Recombinant Proteins; Transfection

2000
Involvement of central opioid systems in human interferon-alpha induced immobility in the mouse forced swimming test.
    British journal of pharmacology, 2000, Volume: 130, Issue:6

    Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Interferon-alpha; Interferon-beta; Interferon-gamma; Male; Mice; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Swimming; Time Factors

2000
Antinociceptive effects of Nigella sativa oil and its major component, thymoquinone, in mice.
    European journal of pharmacology, 2000, Jul-14, Volume: 400, Issue:1

    Topics: Analgesics, Non-Narcotic; Animals; Benzoquinones; Dose-Response Relationship, Drug; Drug Tolerance; Injections, Intraventricular; Male; Mice; Motor Activity; Naloxone; Naltrexone; Plant Oils; Plants, Medicinal

2000
Morphine stimulates mesangial cell TNF-alpha and nitrite production.
    Inflammation, 2000, Volume: 24, Issue:5

    Topics: Animals; Antibodies, Monoclonal; Cell Line, Transformed; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Gene Expression Regulation; Glomerular Mesangium; Glomerulosclerosis, Focal Segmental; Heroin Dependence; HIV Envelope Protein gp120; HIV Infections; Lipopolysaccharides; Macrophages; Mice; Morphine; Muscle, Smooth, Vascular; Naloxone; Naltrexone; Narcotic Antagonists; NG-Nitroarginine Methyl Ester; Nitrites; Tumor Necrosis Factor-alpha

2000
Differential involvement of opioid receptors in stress-induced antinociception caused by repeated exposure to forced walking stress in mice.
    Pharmacology, 2000, Volume: 61, Issue:2

    Topics: Animals; Formaldehyde; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Receptors, Opioid; Stress, Physiological; Walking

2000
Selectivity of mu-opioid receptor determined by interfacial residues near third extracellular loop.
    European journal of pharmacology, 2000, Sep-01, Volume: 403, Issue:1-2

    Topics: Amino Acid Substitution; Animals; Benzamides; Benzomorphans; Binding Sites; Binding, Competitive; COS Cells; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Fentanyl; Guanosine 5'-O-(3-Thiotriphosphate); Ligands; Morphine; Mutation; Naloxone; Naltrexone; Narcotic Antagonists; Peptides; Piperazines; Protein Conformation; Radioligand Assay; Rats; Receptors, Opioid, mu; Signal Transduction; Sulfur Radioisotopes

2000
Morphine discriminative control is mediated by the mu opioid receptor: assessment of delta opioid substitution and antagonism.
    Pharmacology, biochemistry, and behavior, 2000, Volume: 66, Issue:4

    Topics: Animals; Benzamides; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Female; Generalization, Response; Methadone; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Piperazines; Rats; Rats, Long-Evans; Receptors, Opioid, delta; Receptors, Opioid, mu

2000
Synthesis and antinociceptive activity of pyrrolidinylnaphthalenes.
    Bioorganic & medicinal chemistry, 2000, Volume: 8, Issue:8

    Topics: Analgesics; Animals; Drug Design; Male; Mice; Molecular Structure; Motor Activity; Naloxone; Naltrexone; Naphthalenes; Narcotic Antagonists; Pyrrolidines; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship

2000
Differential antagonism of endomorphin-1 and endomorphin-2 spinal antinociception by naloxonazine and 3-methoxynaltrexone.
    Brain research, 2000, Oct-20, Volume: 881, Issue:1

    Topics: Analgesics, Opioid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Heroin; Injections, Spinal; Male; Mice; Naloxone; Naltrexone; Oligopeptides; Pain Measurement; Receptors, Opioid, mu

2000
Kinetics and inhibition of the formation of 6beta-naltrexol from naltrexone in human liver cytosol.
    British journal of clinical pharmacology, 2000, Volume: 50, Issue:5

    Topics: Adult; Aged; Analgesics, Opioid; Benzodiazepines; Chromatography, High Pressure Liquid; Corticosterone; Cytosol; Dihydrotestosterone; Enzyme Inhibitors; Humans; Kinetics; Liver; Microsomes, Liver; Middle Aged; Naloxone; Naltrexone; Oxidoreductases; Oxycodone; Reproducibility of Results; Substrate Specificity; Testosterone; Vitamin K

2000
Dose- and time-dependent bimodal effects of kappa-opioid agonists on locomotor activity in mice.
    The Journal of pharmacology and experimental therapeutics, 2000, Volume: 295, Issue:3

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetamides; Animals; Benzomorphans; Dose-Response Relationship, Drug; Isothiocyanates; Male; Mice; Morphine; Motor Activity; Naloxone; Naltrexone; Receptors, Opioid, kappa; Time Factors

2000
Morphine inhibits human microglial cell production of, and migration towards, RANTES.
    Journal of psychopharmacology (Oxford, England), 2000, Volume: 14, Issue:3

    Topics: Brain; Calcium; Cells, Cultured; Chemokine CCL5; Chemotaxis; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Fetus; Humans; Interleukin-1; Lipopolysaccharides; Microglia; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Recombinant Proteins

2000
Acoustic startle and open-field behavior in mice bred for magnitude of swim analgesia.
    Physiology & behavior, 2000, Sep-15, Volume: 70, Issue:5

    Topics: Acoustic Stimulation; Animals; Behavior, Animal; Brain; Female; Male; Mice; Mice, Inbred Strains; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Receptors, Opioid; Reflex, Startle; Sex Factors; Spatial Behavior; Swimming

2000
Blockade of mu-opioid receptors reveals the hyperalgesic effect of orphanin FQ/nociceptin in the rat hot plate test.
    British journal of pharmacology, 2000, Volume: 131, Issue:8

    Topics: Animals; Dose-Response Relationship, Drug; Female; Hot Temperature; Hyperalgesia; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptin; Opioid Peptides; Pain Measurement; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid, mu; Somatostatin

2000
Inhibition of passive cutaneous anaphylaxis-associated scratching behavior by mu-opioid receptor antagonists in ICR mice.
    International archives of allergy and immunology, 2000, Volume: 123, Issue:4

    Topics: Animals; Behavior, Animal; Capillary Permeability; Female; Histamine; Humans; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Narcotic Antagonists; p-Methoxy-N-methylphenethylamine; Passive Cutaneous Anaphylaxis; Pruritus; Receptors, Opioid, mu

2000
Injections of an opioid antagonist into the locus coeruleus and periaqueductal gray but not the amygdala precipitates morphine withdrawal in the 7-day-old rat.
    Synapse (New York, N.Y.), 2001, Volume: 39, Issue:2

    Topics: Age Factors; Amygdala; Animals; Animals, Newborn; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Locus Coeruleus; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Neural Pathways; Opioid-Related Disorders; Periaqueductal Gray; Quaternary Ammonium Compounds; Rats; Rats, Long-Evans; Substance Withdrawal Syndrome

2001
Suppression of ethanol responding by centrally administered CTOP and naltrindole in AA and Wistar rats.
    Alcoholism, clinical and experimental research, 2001, Volume: 25, Issue:1

    Topics: Alcohol Drinking; Amygdala; Animals; Central Nervous System Depressants; Conditioning, Operant; Ethanol; Genotype; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Reinforcement, Psychology; Self Administration; Somatostatin

2001
[Evolution and update of detoxification techniques for opiate addicts].
    Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 2000, Volume: 20, Issue:4

    Topics: Animals; Buprenorphine; Humans; Methadone; Naloxone; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Substance Withdrawal Syndrome

2000
Role of PAG in the antinociception evoked from the medial or central amygdala in rats.
    Brain research bulletin, 2001, Jan-01, Volume: 54, Issue:1

    Topics: Adrenergic beta-Antagonists; Amygdala; Anesthetics, Local; Animals; Atropine; Electric Stimulation; Ganglionic Blockers; Lidocaine; Male; Mecamylamine; Methysergide; Microinjections; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Pain Threshold; Parasympatholytics; Periaqueductal Gray; Propranolol; Rats; Rats, Wistar; Serotonin Antagonists

2001
Pharmacological effects of naltriben as a ligand for opioid mu and kappa receptors in rat cerebral cortex.
    Life sciences, 2001, Feb-02, Volume: 68, Issue:11

    Topics: Animals; Cerebral Cortex; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Ligands; Male; Naloxone; Naltrexone; Narcotic Antagonists; Norepinephrine; Peptide Fragments; Peptides; Potassium; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin; Tritium

2001
Blockade of delta opioid receptors in the ventrolateral periaqueductal gray region inhibits the fall in arterial pressure evoked by hemorrhage.
    The Journal of pharmacology and experimental therapeutics, 2001, Volume: 297, Issue:2

    Topics: Animals; beta-Endorphin; Blood Pressure; Hemorrhage; Homocysteine; Male; Microinjections; Naloxone; Naltrexone; Narcotic Antagonists; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta

2001
TRK-820, a selective kappa-opioid agonist, produces potent antinociception in cynomolgus monkeys.
    Japanese journal of pharmacology, 2001, Volume: 85, Issue:3

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Behavior, Animal; Macaca fascicularis; Morphinans; Morphine; Naloxone; Naltrexone; Pain Measurement; Pentazocine; Pentobarbital; Receptors, Opioid, kappa; Spiro Compounds

2001
Endogenous opioids suppress activation of nociceptors by sub-nanomolar nicotine.
    British journal of pharmacology, 2001, Volume: 133, Issue:1

    Topics: Adrenal Medulla; Analysis of Variance; Animals; Animals, Newborn; Bradykinin; Capsaicin; Dose-Response Relationship, Drug; Hexamethonium; Inflammation; Knee Joint; Male; Naloxone; Naltrexone; Narcotic Antagonists; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Nicotine; Nociceptors; Opioid Peptides; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Opioid; Sciatic Nerve; Time Factors

2001
Enhancement of the effects of a complete inhibitor of enkephalin-catabolizing enzymes, RB 101, by a cholecystokinin-B receptor antagonist in diabetic rats.
    British journal of pharmacology, 2001, Volume: 133, Issue:1

    Topics: Aminopeptidases; Animals; Diabetes Mellitus, Experimental; Disulfides; Drug Synergism; Indoles; Male; Meglumine; Naloxone; Naltrexone; Neprilysin; Pain; Pain Measurement; Phenylalanine; Pressure; Rats; Rats, Sprague-Dawley; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Time Factors; Vocalization, Animal; Weight Loss

2001
Pharmacological characterization of the dermorphin analog [Dmt(1)]DALDA, a highly potent and selective mu-opioid peptide.
    European journal of pharmacology, 2001, May-04, Volume: 419, Issue:1

    Topics: Analgesics; Animals; Drug Tolerance; Humans; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Oligodeoxyribonucleotides, Antisense; Oligopeptides; Opioid Peptides; Pain Measurement; Receptors, Opioid, mu; Time Factors

2001
Stimulation of guanosine-5'-o-(3-[35S]thio)triphosphate binding in digitonin-permeabilized C6 rat glioma cells: evidence for an organized association of mu-opioid receptors and G protein.
    The Journal of pharmacology and experimental therapeutics, 2001, Volume: 298, Issue:1

    Topics: Analgesics, Opioid; Animals; Digitonin; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Glioma; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Indicators and Reagents; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Receptors, Opioid, mu; Tumor Cells, Cultured

2001
Blockade of opioid receptors in rostral ventral medulla prevents antihyperalgesia produced by transcutaneous electrical nerve stimulation (TENS).
    The Journal of pharmacology and experimental therapeutics, 2001, Volume: 298, Issue:1

    Topics: Analgesics, Opioid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Hot Temperature; Hyperalgesia; Male; Medulla Oblongata; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Transcutaneous Electric Nerve Stimulation

2001
Chronic exposure to mu-opioid agonists produces constitutive activation of mu-opioid receptors in direct proportion to the efficacy of the agonist used for pretreatment.
    Molecular pharmacology, 2001, Volume: 60, Issue:1

    Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Analgesics, Opioid; Animals; Binding Sites; Cells, Cultured; Cyclic AMP; Down-Regulation; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Receptors, Opioid, mu; Sulfur Radioisotopes; Transfection; Virulence Factors, Bordetella

2001
Inverse agonists and neutral antagonists at mu opioid receptor (MOR): possible role of basal receptor signaling in narcotic dependence.
    Journal of neurochemistry, 2001, Volume: 77, Issue:6

    Topics: Analgesics, Opioid; Animals; Benzylidene Compounds; Cell Line; Cell Membrane; Cyclic AMP; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Kidney; Magnesium; Male; Mice; Mice, Inbred ICR; Morphine; Morphine Dependence; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Receptors, Opioid, mu; Signal Transduction; Substance Withdrawal Syndrome; Sulfur Radioisotopes; Transfection; Tritium

2001
Analgesic and antiinflammatory effects of two novel kappa-opioid peptides.
    Anesthesiology, 2001, Volume: 94, Issue:6

    Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzeneacetamides; Dose-Response Relationship, Drug; Inflammation; Injections, Spinal; Male; Naloxone; Naltrexone; Narcotic Antagonists; Opioid Peptides; Pain Threshold; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, kappa

2001
Signal transduction of opioid-induced cardioprotection in ischemia-reperfusion.
    Anesthesiology, 2001, Volume: 94, Issue:6

    Topics: Animals; ATP-Binding Cassette Transporters; Benzamides; Benzylidene Compounds; Cell Survival; Chick Embryo; Decanoic Acids; Free Radicals; Hydroxy Acids; KATP Channels; Myocardial Reperfusion Injury; Myocardium; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Oxidative Stress; Piperazines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Opioid, delta; Signal Transduction

2001
Opioid and GABA receptors involved in mediation and modulation of tonic and stimulus-evoked inhibition of a spinal reflex in the decerebrated and spinalized rabbit.
    Neuropharmacology, 2001, Volume: 41, Issue:3

    Topics: Animals; Bicuculline; Conditioning, Classical; Decerebrate State; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Methionine; Female; GABA Antagonists; Male; Muscle Tonus; Naloxone; Naltrexone; Narcotic Antagonists; Organophosphorus Compounds; Rabbits; Receptors, GABA; Receptors, Opioid; Receptors, Opioid, mu; Receptors, sigma; Reflex

2001
Differential antinociceptive effects induced by intrathecally administered endomorphin-1 and endomorphin-2 in the mouse.
    European journal of pharmacology, 2001, Sep-21, Volume: 427, Issue:3

    Topics: Analgesics; Animals; Benzylidene Compounds; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Methionine; Immune Sera; Injections, Spinal; Injections, Subcutaneous; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain; Pain Measurement; Pain Threshold; Peptide Fragments; Time Factors

2001
Naltrexone potentiates anti-HIV-1 activity of antiretroviral drugs in CD4+ lymphocyte cultures.
    Drug and alcohol dependence, 2001, Nov-01, Volume: 64, Issue:3

    Topics: Anti-HIV Agents; CD4-Positive T-Lymphocytes; Cells, Cultured; Drug Combinations; Drug Synergism; HIV-1; Humans; Indinavir; Naloxone; Naltrexone; Narcotic Antagonists; Zidovudine

2001
Naloxone fails to produce conditioned place aversion in mu-opioid receptor knock-out mice.
    Neuroscience, 2001, Volume: 106, Issue:4

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Avoidance Learning; Brain; Conditioning, Psychological; Dose-Response Relationship, Drug; Habituation, Psychophysiologic; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Opioid Peptides; Phenotype; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Synaptic Transmission

2001
The effect of the leucopyrokinin analogue: [2-8]-leucopyrokinin on central opioid receptors in rats.
    Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 2001, Volume: 130, Issue:3

    Topics: Analgesia; Analgesics; Animals; Dose-Response Relationship, Drug; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Oligopeptides; Peptide Fragments; Rats; Rats, Wistar; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tail; Time Factors

2001
[The combined use of scopolamine, naltrexone and naloxone as a rapid, safe and effective detoxification treatment for heroin addicts].
    Zhonghua yi xue za zhi, 1999, Volume: 79, Issue:9

    Topics: Adult; Drug Therapy, Combination; Female; Follow-Up Studies; Heroin Dependence; Humans; Male; Naloxone; Naltrexone; Narcotic Antagonists; Scopolamine

1999
Endomorphin-1 improves scopolamine-induced impairment of short-term memory via mu1-opioid receptor in mice.
    Neuroreport, 2001, Dec-04, Volume: 12, Issue:17

    Topics: Analgesics, Opioid; Animals; Brain; Dose-Response Relationship, Drug; Drug Interactions; Male; Maze Learning; Memory Disorders; Memory, Short-Term; Mice; Muscarinic Antagonists; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Oligopeptides; Receptors, Opioid, mu; Scopolamine

2001
Morphine upregulates kappa-opioid receptors of human lymphocytes.
    Advances in experimental medicine and biology, 2001, Volume: 493

    Topics: Animals; Cell Line; Humans; Hybrid Cells; Immunosuppressive Agents; Lymphocytes; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, kappa; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Up-Regulation

2001
Opioid and cholecystokinin antagonists alleviate gastric inhibition of food intake by premeal loads of casein in meal-fed rats.
    The Journal of nutrition, 2001, Volume: 131, Issue:12

    Topics: Amino Acids; Animals; Blood Glucose; Caseins; Cholecystokinin; Diet; Dietary Proteins; Eating; Feces; Insulin; Insulin-Like Growth Factor I; Intestines; Male; Naloxone; Naltrexone; Narcotic Antagonists; Proglumide; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley; Soybean Proteins; Stomach

2001
Neuroanatomical and psychopharmacological evidence for interaction between opioid and GABAergic neural pathways in the modulation of fear and defense elicited by electrical and chemical stimulation of the deep layers of the superior colliculus and dorsal
    Neuropharmacology, 2002, Volume: 42, Issue:1

    Topics: Aggression; Animals; Bicuculline; Electric Stimulation; Fear; GABA Antagonists; Immunohistochemistry; Male; Mesencephalon; Microinjections; Naloxone; Naltrexone; Narcotic Antagonists; Neural Pathways; Neurons; Periaqueductal Gray; Rats; Rats, Wistar; Receptors, GABA; Receptors, Opioid; Stimulation, Chemical; Superior Colliculi

2002
Immunomodulation by opioid peptidomimetic compound.
    Neuroimmunomodulation, 2001, Volume: 9, Issue:3

    Topics: Animals; Cells, Cultured; Humans; Leukocytes, Mononuclear; Macrophages; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Neuroimmunomodulation; Nitric Oxide; Opioid Peptides; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Tumor Necrosis Factor-alpha

2001
Comparison of the peripheral and central effects of the opioid agonists loperamide and morphine in the formalin test in rats.
    Neuropharmacology, 2002, Volume: 42, Issue:2

    Topics: Analgesics, Opioid; Animals; Antidiarrheals; Cisterna Magna; Dose-Response Relationship, Drug; Formaldehyde; Injections; Injections, Subcutaneous; Loperamide; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu

2002
[Role of delta opioid receptors and their ligands in the development of adaptive heart protection against arrhythmogenesis].
    Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2001, Volume: 87, Issue:12

    Topics: Adaptation, Physiological; Animals; Arrhythmias, Cardiac; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Ligands; Male; Myocardial Reperfusion Injury; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Rats; Rats, Wistar; Receptors, Opioid, delta; Tetrahydroisoquinolines; Thiorphan

2001
Itch-associated response induced by experimental dry skin in mice.
    Japanese journal of pharmacology, 2002, Volume: 88, Issue:3

    Topics: Animals; Behavior, Animal; Blood-Air Barrier; Male; Mast Cells; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Narcotic Antagonists; Pruritus; Skin; Skin Diseases; Water Loss, Insensible

2002
Motivational effects mu- and kappa-opioid agonists following acute and chronic restraint stress: involvement of dopamine D(1) and D(2) receptors.
    Behavioural brain research, 2002, May-14, Volume: 132, Issue:2

    Topics: Acute Disease; Animals; Behavior, Animal; Benzomorphans; Chronic Disease; Conditioning, Operant; Injections, Intraventricular; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stress, Psychological

2002
In vivo and in vitro potency studies of 6beta-naltrexol, the major human metabolite of naltrexone.
    Addiction biology, 2002, Volume: 7, Issue:2

    Topics: Animals; Culture Techniques; Dose-Response Relationship, Drug; Gastrointestinal Motility; Guinea Pigs; Ileum; Isometric Contraction; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Pain Threshold; Receptors, Opioid, mu

2002
Anti-nociceptive effect of neuropeptide Y in the nucleus accumbens of rats: an involvement of opioid receptors in the effect.
    Brain research, 2002, Jun-14, Volume: 940, Issue:1-2

    Topics: Animals; Catheterization; Dose-Response Relationship, Drug; Hot Temperature; Male; Microinjections; Naloxone; Naltrexone; Narcotic Antagonists; Neuropeptide Y; Nucleus Accumbens; Pain Measurement; Peptide Fragments; Physical Stimulation; Rats; Rats, Wistar; Receptors, Neuropeptide Y; Receptors, Opioid

2002
Sevoflurane suppresses noxious stimulus-evoked expression of Fos-like immunoreactivity in the rat spinal cord via activation of endogenous opioid systems.
    Life sciences, 2002, Jun-21, Volume: 71, Issue:5

    Topics: Analgesics; Anesthetics, Inhalation; Animals; Formaldehyde; Male; Methyl Ethers; Naloxone; Naltrexone; Narcotic Antagonists; Opioid Peptides; Pain Measurement; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Sevoflurane; Spinal Cord

2002
Differential antagonism of endomorphin-1 and endomorphin-2 supraspinal antinociception by naloxonazine and 3-methylnaltrexone.
    Peptides, 2002, Volume: 23, Issue:5

    Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Injections, Spinal; Male; Mice; Naloxone; Naltrexone; Oligopeptides; Pain; Pain Measurement; Quaternary Ammonium Compounds; Reflex; Time Factors

2002
Blockade of nigral and pallidal opioid receptors suppresses vacuous chewing movements in a rodent model of tardive dyskinesia.
    Neuroscience, 2002, Volume: 112, Issue:4

    Topics: Animals; Dose-Response Relationship, Drug; Dynorphins; Dyskinesia, Drug-Induced; Fluphenazine; Globus Pallidus; Male; Mastication; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Somatostatin; Substantia Nigra

2002
Involvement of endogenous opioid systems in nociceptin-induced spinal antinociception in rats.
    Brain research, 2002, Jul-26, Volume: 945, Issue:1

    Topics: Animals; Endorphins; Hindlimb; Hot Temperature; Injections, Spinal; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptin; Nociceptors; Opioid Peptides; Pain; Pain Measurement; Peptide Fragments; Physical Stimulation; Rats; Rats, Sprague-Dawley; Spinal Cord

2002
Possible involvement of mu1-opioid receptors in the fentanyl- or morphine-induced antinociception at supraspinal and spinal sites.
    Life sciences, 2002, Apr-05, Volume: 70, Issue:20

    Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Fentanyl; Injections, Intraventricular; Injections, Spinal; Injections, Subcutaneous; Male; Mice; Mice, Inbred C57BL; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Receptors, Opioid, mu; Spinal Cord

2002
Effects of opioid antagonists on unconditioned and conditioned hyperactivity to morphine.
    Pharmacology, biochemistry, and behavior, 2002, Volume: 73, Issue:3

    Topics: Analgesics, Opioid; Animals; Conditioning, Operant; Dose-Response Relationship, Drug; Hyperkinesis; Male; Morphine; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu

2002
Chronic agonist treatment converts antagonists into inverse agonists at delta-opioid receptors.
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 302, Issue:3

    Topics: Adenylyl Cyclases; Analgesics, Opioid; Animals; Cell Line; Cell Membrane; Drug Tolerance; Enkephalin, D-Penicillamine (2,5)-; Guanosine 5'-O-(3-Thiotriphosphate); Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Receptors, Opioid, delta; Receptors, Opioid, mu

2002
Lack of the nociceptin receptor does not affect acute or chronic nociception in mice.
    Peptides, 2002, Volume: 23, Issue:9

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Female; Male; Mice; Mice, Knockout; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptin; Nociceptin Receptor; Oligopeptides; Opioid Peptides; Pain; Receptors, Opioid; Time Factors; Vas Deferens

2002
Different effects of methionine-enkephalin on paw edema in two inbred rat strains.
    Peptides, 2002, Volume: 23, Issue:9

    Topics: Animals; Dexamethasone; Dose-Response Relationship, Drug; Edema; Enkephalin, Methionine; Glucocorticoids; Inflammation; Kinetics; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Species Specificity; Time Factors

2002
Effect of selective blockade of mu(1) or delta opioid receptors on reinstatement of alcohol-seeking behavior by drug-associated stimuli in rats.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2002, Volume: 27, Issue:3

    Topics: Alcohol Drinking; Analysis of Variance; Animals; Central Nervous System Depressants; Cues; Discrimination, Psychological; Ethanol; Extinction, Psychological; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Reinforcement, Psychology; Self Administration

2002
Quantitative stoichiometry of G-proteins activated by mu-opioid receptors in postmortem human brain.
    European journal of pharmacology, 2002, Sep-27, Volume: 452, Issue:1

    Topics: Alkylation; Analgesics, Opioid; Baclofen; Binding, Competitive; Brain Chemistry; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enzyme Inhibitors; Ethylmaleimide; GABA Agonists; GTP-Binding Protein Regulators; GTP-Binding Proteins; Humans; In Vitro Techniques; Kinetics; Membranes; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu; Signal Transduction

2002
Focal kappa-opioid receptor-mediated dependence and withdrawal in the nucleus paragigantocellularis.
    Pharmacology, biochemistry, and behavior, 2002, Volume: 74, Issue:1

    Topics: Animals; Basal Ganglia; Butorphanol; Diffusion; Electric Stimulation; Male; Microinjections; Morphine; Morphine Dependence; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Stereotaxic Techniques; Stereotyped Behavior; Substance Withdrawal Syndrome

2002
Functional interactions between delta- and mu-opioid receptors in rat thermoregulation.
    European journal of pharmacology, 2003, Jan-01, Volume: 458, Issue:1-2

    Topics: Animals; Body Temperature; Body Temperature Regulation; Dose-Response Relationship, Drug; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptor Cross-Talk; Receptors, Opioid, delta; Receptors, Opioid, mu

2003
Effects of beta-funaltrexamine and naloxonazine on single-trial morphine-conditioned place preference and locomotor activity.
    Pharmacology, biochemistry, and behavior, 2003, Volume: 74, Issue:3

    Topics: Animals; Conditioning, Psychological; Male; Morphine; Motor Activity; Naloxone; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu

2003
Opioid receptor antagonists modulate Ca2+-activated K+ channels in mesenteric arterial smooth muscle cells of rats in hemorrhagic shock.
    Shock (Augusta, Ga.), 2003, Volume: 19, Issue:1

    Topics: Animals; Calcium; Dose-Response Relationship, Drug; Down-Regulation; Electrophysiology; Kinetics; Membrane Potentials; Mesenteric Arteries; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Naloxone; Naltrexone; Narcotic Antagonists; Potassium Channels; Rats; Rats, Wistar; Shock, Hemorrhagic

2003
Endogenous opioid peptides contribute to antinociceptive potency of intrathecal [Dmt1]DALDA.
    The Journal of pharmacology and experimental therapeutics, 2003, Volume: 305, Issue:2

    Topics: Analgesics, Opioid; Animals; Antibodies, Blocking; Cloning, Molecular; Dynorphins; Endorphins; Enkephalin, Methionine; Guanosine 5'-O-(3-Thiotriphosphate); Hot Temperature; Injections, Intraventricular; Injections, Spinal; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain Measurement; Radioligand Assay; Reaction Time; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu

2003
Discriminative stimulus effects of acute morphine followed by naltrexone in the squirrel monkey.
    Psychopharmacology, 2003, Volume: 167, Issue:2

    Topics: Animals; Benzeneacetamides; Conditioning, Operant; Dextrorphan; Discrimination Learning; Dose-Response Relationship, Drug; Generalization, Psychological; Levorphanol; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pyrrolidines; Receptors, Opioid; Saimiri; Substance Withdrawal Syndrome

2003
Behavioral and neuroendocrine actions of the Met-enkephalin-related peptide MERF.
    Hormones and behavior, 2003, Volume: 43, Issue:2

    Topics: Analysis of Variance; Animals; Behavior, Animal; Corticotropin-Releasing Hormone; Dopamine; Enkephalin, Methionine; Exploratory Behavior; Haloperidol; Hormone Antagonists; Hypothalamo-Hypophyseal System; Male; Mice; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Neostriatum; Organ Culture Techniques; Peptide Fragments; Pituitary-Adrenal System

2003
The antitussive effects of endomorphin-1 and endomorphin-2 in mice.
    European journal of pharmacology, 2003, Apr-25, Volume: 467, Issue:1-3

    Topics: Animals; Antitussive Agents; Capsaicin; Cough; Dose-Response Relationship, Drug; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Oligopeptides; Receptors, Opioid, kappa; Receptors, Opioid, mu

2003
Opiate withdrawal induces Narp in the extended amygdala.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2003, Volume: 28, Issue:9

    Topics: Amygdala; Analgesics; Animals; C-Reactive Protein; Cell Count; Clonidine; Dose-Response Relationship, Drug; Immunohistochemistry; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nerve Tissue Proteins; Nucleus Accumbens; Opioid-Related Disorders; Rats; Rats, Sprague-Dawley; Septal Nuclei; Substance Withdrawal Syndrome

2003
Chemical anesthesia of northern sea otters (Enhydra lutris): results of past field studies.
    Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians, 2001, Volume: 32, Issue:2

    Topics: Anesthesia; Anesthetics, Combined; Anesthetics, Intravenous; Animals; Azaperone; Body Temperature; Diazepam; Female; Fentanyl; Heart Rate; Hypnotics and Sedatives; Immobilization; Logistic Models; Male; Naloxone; Naltrexone; Narcotic Antagonists; Otters; Respiration; Seizures; Time Factors; Tremor

2001
Neuroprotection of naloxone against ischemic injury in rats: role of mu receptor antagonism.
    Neuroscience letters, 2003, Jul-24, Volume: 345, Issue:3

    Topics: Animals; Carotid Artery, Common; Cerebral Infarction; Coronary Disease; Functional Laterality; Hypoxia-Ischemia, Brain; Infarction, Middle Cerebral Artery; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Time Factors

2003
Effects of U50,488H on transient outward and ultra-rapid delayed rectifier K+ currents in young human atrial myocytes.
    European journal of pharmacology, 2003, Jul-25, Volume: 473, Issue:2-3

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adolescent; Child; Child, Preschool; Delayed Rectifier Potassium Channels; Female; Heart Atria; Humans; Infant; Male; Myocytes, Cardiac; Naloxone; Naltrexone; Narcotic Antagonists; Patch-Clamp Techniques; Potassium Channels; Potassium Channels, Tandem Pore Domain; Potassium Channels, Voltage-Gated; Receptors, Opioid, kappa

2003
[Dual regulation by delta opioid receptor agonists on the delayed rectified potassium channels in NG108-15 cells].
    Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 2003, Volume: 25, Issue:2

    Topics: Animals; Cell Membrane; Enkephalin, D-Penicillamine (2,5)-; Glioma; Hybrid Cells; Mice; Naloxone; Naltrexone; Neuroblastoma; Patch-Clamp Techniques; Potassium Channels, Inwardly Rectifying; Rats; Receptors, Opioid, delta; Tumor Cells, Cultured

2003
Involvement of oxytocin in spinal antinociception in rats with inflammation.
    Brain research, 2003, Sep-05, Volume: 983, Issue:1-2

    Topics: Analgesics; Animals; Carrageenan; Hot Temperature; Inflammation; Injections, Spinal; Male; Naloxone; Naltrexone; Narcotic Antagonists; Oxytocin; Pain; Pain Measurement; Physical Stimulation; Rats; Rats, Wistar; Spinal Cord; Vasotocin

2003
kappa-Opioid withdrawal in Planaria.
    Neuroscience letters, 2003, Oct-09, Volume: 349, Issue:3

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adaptation, Physiological; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Hydrogen-Ion Concentration; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Osmolar Concentration; Planarians; Reaction Time; Receptors, Opioid, kappa; Substance Withdrawal Syndrome

2003
Expression of EGFP-amino-tagged human mu opioid receptor in Drosophila Schneider 2 cells: a potential expression system for large-scale production of G-protein coupled receptors.
    Protein expression and purification, 2003, Volume: 31, Issue:1

    Topics: Animals; Binding, Competitive; Blotting, Western; Cell Line; Cloning, Molecular; Colforsin; Copper Sulfate; Cyclic AMP; Diprenorphine; DNA, Complementary; Drosophila; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Gene Expression; Genetic Vectors; Green Fluorescent Proteins; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Luminescent Proteins; Metallothionein; Microscopy, Confocal; Morphine; Naloxone; Naltrexone; Oligopeptides; Opioid Peptides; Pertussis Toxin; Polymerase Chain Reaction; Protein Binding; Receptors, G-Protein-Coupled; Receptors, Opioid, mu; Recombinant Fusion Proteins; Spectrometry, Fluorescence; Thermodynamics

2003
An opioid basis for early-phase isoflurane-induced hypotension in rats.
    Life sciences, 2003, Oct-03, Volume: 73, Issue:20

    Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Antibodies, Blocking; beta-Endorphin; Blood Pressure; Endorphins; Enkephalin, Methionine; Hot Temperature; Hypotension; Injections, Intraventricular; Isoflurane; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid; Urethane

2003
Effects of endomorphin on substantia gelatinosa neurons in rat spinal cord slices.
    British journal of pharmacology, 2003, Volume: 140, Issue:6

    Topics: Animals; Bicuculline; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Excitatory Postsynaptic Potentials; Female; Male; Membrane Potentials; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Oligopeptides; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Spinal Cord; Substantia Gelatinosa; Tetrodotoxin; Time Factors

2003
Dynorphinergic mechanism mediating endomorphin-2-induced antianalgesia in the mouse spinal cord.
    The Journal of pharmacology and experimental therapeutics, 2003, Volume: 307, Issue:3

    Topics: Analgesics, Opioid; Animals; Antibodies, Blocking; Dizocilpine Maleate; Dose-Response Relationship, Drug; Dynorphins; Excitatory Amino Acid Antagonists; Injections, Spinal; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain Measurement; Reaction Time; Receptors, Opioid; Spinal Cord

2003
Opioid antagonists increase the dyskinetic response to dopaminergic agents in parkinsonian monkeys: interaction between dopamine and opioid systems.
    Neuropharmacology, 2003, Volume: 45, Issue:7

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Benzazepines; Dopamine; Dopamine Agents; Dopamine Agonists; Dyskinesia, Drug-Induced; Endorphins; Female; Levodopa; Macaca fascicularis; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Parkinson Disease, Secondary; Quinpirole; Receptors, Dopamine D1; Receptors, Dopamine D2; Synaptic Transmission

2003
Effect of opioid receptor ligands on the mu-S196A knock-in and mu knockout mouse vas deferens.
    European journal of pharmacology, 2003, Oct-08, Volume: 478, Issue:2-3

    Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Enkephalin, Leucine-2-Alanine; In Vitro Techniques; Ligands; Male; Mice; Mice, Knockout; Mice, Transgenic; Morphine; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Receptors, Opioid; Vas Deferens

2003
Delta opioid receptors are involved in morphine-induced inhibition of luteinizing hormone releasing hormone in SK-N-SH cells.
    Neuropeptides, 2003, Volume: 37, Issue:5

    Topics: Analgesics, Opioid; Cell Line, Tumor; Dose-Response Relationship, Drug; Gonadotropin-Releasing Hormone; Humans; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Neuroblastoma; Receptors, Opioid, delta; Somatostatin

2003
Reassessment of buprenorphine in conditioned place preference: temporal and pharmacological considerations.
    Psychopharmacology, 2004, Volume: 172, Issue:1

    Topics: Animals; Buprenorphine; Conditioning, Operant; Dose-Response Relationship, Drug; Male; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Nociceptin Receptor; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, kappa; Time Factors

2004
Neuroanatomical and neuropharmacological study of opioid pathways in the mesencephalic tectum: effect of mu(1)- and kappa-opioid receptor blockade on escape behavior induced by electrical stimulation of the inferior colliculus.
    Brain research, 2003, Dec-05, Volume: 992, Issue:2

    Topics: Animals; Biotin; Dextrans; Dose-Response Relationship, Drug; Electric Stimulation; Escape Reaction; Fear; Inferior Colliculi; Male; Naloxone; Naltrexone; Narcotic Antagonists; Neural Pathways; Opioid Peptides; Periaqueductal Gray; Presynaptic Terminals; Rats; Rats, Wistar; Receptors, Opioid, kappa; Receptors, Opioid, mu

2003
Mechanisms of the effects of adrenocorticotropic hormone on pain sensitivity in rats.
    Neuroscience and behavioral physiology, 2003, Volume: 33, Issue:8

    Topics: Adrenocorticotropic Hormone; Animals; Drug Interactions; Hydrocortisone; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Pain Threshold; Rats; Rats, Sprague-Dawley; Time Factors

2003
Combined low dose treatment with opioid and cannabinoid receptor antagonists synergistically reduces the motivation to consume alcohol in rats.
    Psychopharmacology, 2004, Volume: 173, Issue:1-2

    Topics: Alcohol Drinking; Animals; Cannabinoids; Dose-Response Relationship, Drug; Drug Combinations; Drug Synergism; Male; Motivation; Naloxone; Naltrexone; Narcotic Antagonists; Piperidines; Pyrazoles; Rats; Rats, Wistar; Rimonabant

2004
Radial arm maze performance of rats following repeated low level microwave radiation exposure.
    Bioelectromagnetics, 2004, Volume: 25, Issue:1

    Topics: Animals; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Resistance; Male; Maze Learning; Microwaves; Naloxone; Naltrexone; Physostigmine; Psychotropic Drugs; Radiation Dosage; Radiation Tolerance; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity; Task Performance and Analysis; Whole-Body Irradiation

2004
Differential antinociceptive effects of L-arginine and 3-morpholinosydoimine.
    Proceedings of the Western Pharmacology Society, 2003, Volume: 46

    Topics: Analgesics; Animals; Arginine; Dose-Response Relationship, Drug; Dynorphins; Injections, Intraventricular; Male; Mice; Molsidomine; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement

2003
Differential opioid inhibition of C- and A delta- fiber mediated thermonociception after stimulation of the nucleus raphe magnus.
    Anesthesia and analgesia, 2004, Volume: 98, Issue:2

    Topics: Analgesics, Opioid; Animals; Electric Stimulation; Female; Hot Temperature; Injections, Spinal; Naloxone; Naltrexone; Narcotic Antagonists; Nerve Fibers, Myelinated; Nerve Fibers, Unmyelinated; Neural Pathways; Nociceptors; Raphe Nuclei; Rats; Rats, Sprague-Dawley

2004
Social learning about ethanol in preweanling rats: role of endogenous opioids.
    Developmental psychobiology, 2004, Volume: 44, Issue:2

    Topics: Animals; Animals, Newborn; Behavior, Animal; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Ethanol; Learning; Naloxone; Naltrexone; Narcotic Antagonists; Random Allocation; Rats; Rats, Sprague-Dawley; Social Behavior; Weaning

2004
Nonopioidergic mechanism mediating morphine-induced antianalgesia in the mouse spinal cord.
    The Journal of pharmacology and experimental therapeutics, 2004, Volume: 310, Issue:1

    Topics: Analgesia; Animals; beta-Endorphin; Dizocilpine Maleate; Drug Interactions; Drug Tolerance; Dynorphins; Enkephalins; Male; Mice; Morphine; Naloxone; Naltrexone; Oligopeptides; Pain; Pain Measurement; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord; Substance P

2004
Sensitivity of neuronal nicotinic acetylcholine receptors to the opiate antagonists naltrexone and naloxone: receptor blockade and up-regulation.
    Bioorganic & medicinal chemistry letters, 2004, Apr-19, Volume: 14, Issue:8

    Topics: Cell Line; Gene Expression; Humans; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Nicotine; Patch-Clamp Techniques; Receptors, Nicotinic; Sensitivity and Specificity; Smoking Cessation; Structure-Activity Relationship; Time Factors; Up-Regulation

2004
Supraspinal and spinal cord opioid receptors are responsible for antinociception following intrathecal morphine injections.
    European journal of anaesthesiology, 2004, Volume: 21, Issue:3

    Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Injections, Spinal; Male; Models, Animal; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Pain; Pain Threshold; Random Allocation; Rats; Rats, Wistar; Reaction Time; Receptors, Opioid; Spinal Cord; Tail

2004
Functional opioid pathways are necessary for hypocretin-1 (orexin-A)-induced feeding.
    Peptides, 2004, Volume: 25, Issue:2

    Topics: Animals; Appetite Regulation; Carrier Proteins; Eating; Hypothalamic Area, Lateral; Intracellular Signaling Peptides and Proteins; Male; Naloxone; Naltrexone; Neuropeptides; Orexins; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley

2004
Deltorphin II enhances extracellular levels of dopamine in the nucleus accumbens via opioid receptor-independent mechanisms.
    European journal of pharmacology, 2004, Apr-26, Volume: 491, Issue:1

    Topics: Analysis of Variance; Anesthetics, Local; Animals; Benzylidene Compounds; Dopamine; Extracellular Space; Male; Microdialysis; Naloxone; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Somatostatin; Tetrodotoxin; Time Factors

2004
Opioid growth factor (OGF) inhibits anchorage-independent growth in human cancer cells.
    International journal of oncology, 2004, Volume: 24, Issue:6

    Topics: Adenocarcinoma; Carcinoma, Squamous Cell; Cell Adhesion; Cell Division; Colonic Neoplasms; Colony-Forming Units Assay; Enkephalin, Methionine; Head and Neck Neoplasms; Humans; Naloxone; Naltrexone; Narcotic Antagonists; Pancreatic Neoplasms; Receptors, Opioid; Transplantation, Heterologous; Tumor Cells, Cultured

2004
Supraspinal anti-allodynic and rewarding effects of endomorphins in rats.
    Peptides, 2004, Volume: 25, Issue:4

    Topics: Analgesics, Opioid; Animals; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nerve Compression Syndromes; Oligopeptides; Pain; Pain Management; Pain Measurement; Rats; Rats, Sprague-Dawley

2004
Involvement of opioid receptors in the oxytocin-induced antinociception in the central nervous system of rats.
    Regulatory peptides, 2004, Aug-15, Volume: 120, Issue:1-3

    Topics: Animals; Central Nervous System; Male; Naloxone; Naltrexone; Narcotic Antagonists; Oxytocin; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu

2004
The antinociceptive effect of Delta9-tetrahydrocannabinol in the arthritic rat.
    European journal of pharmacology, 2004, Jun-16, Volume: 493, Issue:1-3

    Topics: Animals; Arthritis, Experimental; Cannabinoid Receptor Antagonists; Dose-Response Relationship, Drug; Dronabinol; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Freund's Adjuvant; Injections, Intradermal; Injections, Intraperitoneal; Male; Morphine; Mycobacterium; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Opioid; Rimonabant

2004
The NMDA receptor channel blocker memantine and opioid receptor antagonist naltrexone inhibit the saccharin deprivation effect in rats.
    Behavioural pharmacology, 2004, Volume: 15, Issue:4

    Topics: Acamprosate; Animals; Choice Behavior; Ethanol; Male; Memantine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Saccharin; Substance Withdrawal Syndrome; Sweetening Agents; Taurine

2004
Plasma concentrations during naltrexone implant treatment of opiate-dependent patients.
    British journal of clinical pharmacology, 2004, Volume: 58, Issue:2

    Topics: Adult; Drug Implants; Female; Humans; Male; Naloxone; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders

2004
A Tyr-W-MIF-1 analog containing D-Pro2 acts as a selective mu2-opioid receptor antagonist in the mouse.
    The Journal of pharmacology and experimental therapeutics, 2005, Volume: 312, Issue:3

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Male; Mice; MSH Release-Inhibiting Hormone; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Receptors, Opioid, mu

2005
Antagonist efficacy in MORS196L mutant is affected by the interaction between transmembrane domains of the opioid receptor.
    The Journal of pharmacology and experimental therapeutics, 2005, Volume: 313, Issue:1

    Topics: Animals; Cyclic AMP; Diprenorphine; Electrophysiology; Mutagenesis, Site-Directed; Mutation; Naloxone; Naltrexone; Narcotic Antagonists; Oocytes; Patch-Clamp Techniques; Radioligand Assay; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Recombinant Fusion Proteins; RNA, Complementary; Xenopus

2005
Opioid-mediated pain sensitivity in mice bred for high voluntary wheel running.
    Physiology & behavior, 2004, Dec-15, Volume: 83, Issue:3

    Topics: Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Breeding; Circadian Rhythm; Dose-Response Relationship, Drug; Female; Male; Mice; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pain Measurement; Pain Threshold; Reaction Time; Running; Selection, Genetic; Species Specificity; Time Factors

2004
The development of tolerance to locomotor effects of morphine and the effect of various opioid receptor antagonists in rats chronically treated with morphine.
    Brain research bulletin, 2005, Jan-15, Volume: 64, Issue:5

    Topics: Animals; Behavior, Animal; Drug Interactions; Male; Morphine; Morphine Dependence; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Wistar; Time Factors

2005
Comment on "Radial arm maze performance of rats following repeated low level microwave radiation exposure".
    Bioelectromagnetics, 2005, Volume: 26, Issue:2

    Topics: Animals; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Resistance; Male; Maze Learning; Microwaves; Naloxone; Naltrexone; Physostigmine; Psychotropic Drugs; Radiation Dosage; Radiation Tolerance; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity; Task Performance and Analysis; Whole-Body Irradiation

2005
Differentiation of opioid receptor preference by [Dmt1]endomorphin-2-mediated antinociception in the mouse.
    European journal of pharmacology, 2005, Feb-10, Volume: 509, Issue:1

    Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Hot Temperature; Injections, Intraventricular; Injections, Subcutaneous; Male; Mice; Naloxone; Naltrexone; Nociceptors; Oligopeptides; Pain; Pain Measurement; Receptors, Opioid, delta; Receptors, Opioid, mu; Tail; Time Factors

2005
In vivo characterization of 6beta-naltrexol, an opioid ligand with less inverse agonist activity compared with naltrexone and naloxone in opioid-dependent mice.
    The Journal of pharmacology and experimental therapeutics, 2005, Volume: 313, Issue:3

    Topics: Animals; Benzylidene Compounds; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice; Mice, Inbred ICR; Morphine; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders

2005
Effect of the blockade of mu1-opioid and 5HT2A-serotonergic/alpha1-noradrenergic receptors on sweet-substance-induced analgesia.
    Psychopharmacology, 2005, Volume: 179, Issue:2

    Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Analgesia; Animals; Dose-Response Relationship, Drug; Ketanserin; Male; Methysergide; Naloxone; Naltrexone; Pain Measurement; Pain Threshold; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT2A; Receptors, Opioid, mu; Serotonin Antagonists; Sucrose; Taste

2005
Inhibitory control of the acute mu-withdrawal response by indirectly activated adenosine A1 and kappa-opioid systems in the Guinea-pig ileum; reversal by cholecystokinin.
    Neurotoxicology, 2005, Volume: 26, Issue:5

    Topics: Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Analgesics, Opioid; Animals; Cholecystokinin; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists; Opioid Peptides; Receptor, Adenosine A1; Receptors, Opioid, kappa; Receptors, Opioid, mu; Substance Withdrawal Syndrome; Theophylline

2005
Opioid antagonists differ according to negative intrinsic efficacy in a mouse model of acute dependence.
    British journal of pharmacology, 2005, Volume: 145, Issue:7

    Topics: Animals; Behavior, Animal; Body Weight; Brain; Diprenorphine; Dose-Response Relationship, Drug; Male; Mice; Morphine; Morphine Dependence; Naloxone; Naltrexone; Narcotic Antagonists; Substance Withdrawal Syndrome; Tremor

2005
Interactions among mu- and delta-opioid receptors, especially putative delta1- and delta2-opioid receptors, promote dopamine release in the nucleus accumbens.
    Neuroscience, 2005, Volume: 135, Issue:1

    Topics: Analgesics, Opioid; Anesthetics, Local; Animals; Benzylidene Compounds; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Extracellular Space; Male; Microdialysis; Naloxone; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Somatostatin; Tetrodotoxin

2005
Physiological control of emotion-related behaviors by endogenous enkephalins involves essentially the delta opioid receptors.
    Neuroscience, 2005, Volume: 135, Issue:2

    Topics: Analysis of Variance; Animals; Anxiety; Behavior, Animal; Disulfides; Dose-Response Relationship, Drug; Drug Interactions; Emotions; Enkephalins; Enzyme Inhibitors; Exploratory Behavior; Freezing Reaction, Cataleptic; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Phenylalanine; Reaction Time; Receptors, Opioid, delta; Receptors, Opioid, mu; Swimming; Time Factors

2005
Attenuation of post-ischemia reperfusion injury by thaliporphine and morphine in rat hearts.
    Journal of biomedical science, 2005, Volume: 12, Issue:4

    Topics: Adenosine Triphosphate; Analgesics, Opioid; Animals; Antioxidants; Aporphines; Creatine Kinase; Dose-Response Relationship, Drug; Heart; Male; Mitochondria; Morphine; Myocardial Ischemia; Myocardium; Naloxone; Naltrexone; Narcotic Antagonists; Peroxidase; Plant Extracts; Potassium; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Risk; Time Factors

2005
Opioid receptors modulate recovery from consummatory successive negative contrast.
    Behavioural brain research, 2005, Nov-07, Volume: 164, Issue:2

    Topics: Animals; Conditioning, Operant; Consummatory Behavior; Inhibition, Psychological; Male; Naloxone; Naltrexone; Narcotic Antagonists; Random Allocation; Rats; Rats, Long-Evans; Receptors, Opioid; Reinforcement, Psychology

2005
Letter to the editor concerning "Radial arm maze performance of rats following repeated low-level microwave radiation exposure" by Cobb et al. [BEMS, 2004, 25:49-57] and "letter to the editor" by Lai [BEMS, 2005, 26:81].
    Bioelectromagnetics, 2005, Volume: 26, Issue:7

    Topics: Animals; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Resistance; Male; Maze Learning; Microwaves; Naloxone; Naltrexone; Physostigmine; Psychotropic Drugs; Radiation Dosage; Radiation Tolerance; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity; Task Performance and Analysis; Whole-Body Irradiation

2005
Letter to the editor concerning Lai's letter on "Radial arm maze performance of rats following repeated low level microwave radiation exposure" [Bioelectromagnetics 25:49-57 (2004)].
    Bioelectromagnetics, 2005, Volume: 26, Issue:7

    Topics: Animals; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Resistance; Male; Maze Learning; Microwaves; Naloxone; Naltrexone; Physostigmine; Psychotropic Drugs; Radiation Dosage; Radiation Tolerance; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity; Task Performance and Analysis; Whole-Body Irradiation

2005
Antinociception, tolerance and withdrawal symptoms induced by 7-hydroxymitragynine, an alkaloid from the Thai medicinal herb Mitragyna speciosa.
    Life sciences, 2005, Nov-19, Volume: 78, Issue:1

    Topics: Analgesics; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Injections, Subcutaneous; Male; Mice; Mitragyna; Models, Molecular; Morphinans; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Reaction Time; Secologanin Tryptamine Alkaloids; Substance Withdrawal Syndrome; Thailand

2005
The role of opioid receptor subtypes in the development of behavioral sensitization to ethanol.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2006, Volume: 31, Issue:7

    Topics: Analysis of Variance; Animals; Behavior, Animal; Central Nervous System Depressants; Dose-Response Relationship, Drug; Ethanol; Male; Mice; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Somatostatin; Time Factors

2006
Coordinated and spatial upregulation of arc in striatonigral neurons correlates with L-dopa-induced behavioral sensitization in dyskinetic rats.
    Journal of neuropathology and experimental neurology, 2005, Volume: 64, Issue:11

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic Agents; AIDS-Related Complex; Amphetamine; Analgesics, Non-Narcotic; Animals; Antiparkinson Agents; Behavior, Animal; Carrier Proteins; Central Nervous System Stimulants; Corpus Striatum; Disease Models, Animal; Drug Interactions; Dynorphins; Dyskinesia, Drug-Induced; Functional Laterality; Homer Scaffolding Proteins; Immunohistochemistry; In Situ Hybridization; Levodopa; Male; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Oxidopamine; Protein Precursors; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Stereotyped Behavior; Substantia Nigra; Time Factors; Tyrosine 3-Monooxygenase; Up-Regulation

2005
Kappa-opioid receptor-mediated effects of the plant-derived hallucinogen, salvinorin A, on inverted screen performance in the mouse.
    Behavioural pharmacology, 2005, Volume: 16, Issue:8

    Topics: Analgesics, Opioid; Animals; Behavior, Animal; Benzeneacetamides; Diterpenes; Diterpenes, Clerodane; Hallucinogens; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Piperidines; Psychotropic Drugs; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Remifentanil

2005
Localization of opioid receptor antagonist [3H]-LY255582 binding sites in mouse brain: comparison with the distribution of mu, delta and kappa binding sites.
    Neuropeptides, 2005, Volume: 39, Issue:6

    Topics: Animals; Autoradiography; Binding Sites; Brain; Cyclohexanes; Mice; Mice, Knockout; Molecular Structure; Naloxone; Naltrexone; Narcotic Antagonists; Piperidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tritium

2005
Effects of systemic administration of beta-casomorphin-5 on learning and memory in mice.
    European journal of pharmacology, 2006, Jan-13, Volume: 530, Issue:1-2

    Topics: Analgesics; Animals; Avoidance Learning; Cattle; Dose-Response Relationship, Drug; Endorphins; Injections, Intraperitoneal; Injections, Intraventricular; Injections, Subcutaneous; Male; Memory; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Peptide Fragments; Receptors, Opioid, mu; Scopolamine

2006
mu- but not delta- and kappa-opioid receptor mediates the nucleus submedius interferon-alpha-evoked antinociception in the rat.
    Neuroscience letters, 2006, Apr-24, Volume: 397, Issue:3

    Topics: Animals; Escape Reaction; Interferon-alpha; Male; Mediodorsal Thalamic Nucleus; Microinjections; Naloxone; Naltrexone; Pain; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid, kappa; Receptors, Opioid, mu

2006
Modulation of Delta(9)-THC-induced increase of cortical and hippocampal acetylcholine release by micro opioid and D(1) dopamine receptors.
    Neuropharmacology, 2006, Volume: 50, Issue:6

    Topics: Acetylcholine; Animals; Behavior, Animal; Benzazepines; Dopamine Antagonists; Dronabinol; Drug Interactions; Hippocampus; Male; Microdialysis; Naloxone; Naltrexone; Narcotic Antagonists; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Opioid, mu; Time Factors

2006
Inhibition of morphine tolerance by processed Aconiti tuber is mediated by kappa-opioid receptors.
    Journal of ethnopharmacology, 2006, Jun-30, Volume: 106, Issue:2

    Topics: Aconitum; Analgesics, Opioid; Animals; Cinnamates; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Drugs, Chinese Herbal; Male; Mice; Morphine; Morphine Derivatives; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Pain Threshold; Plant Tubers; Receptors, Opioid, kappa; Time Factors

2006
Cannabidiol is an allosteric modulator at mu- and delta-opioid receptors.
    Naunyn-Schmiedeberg's archives of pharmacology, 2006, Volume: 372, Issue:5

    Topics: Allosteric Regulation; Analgesics, Opioid; Animals; Cannabidiol; Cerebral Cortex; Dose-Response Relationship, Drug; Dronabinol; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu

2006
Involvements of mu- and kappa-opioid receptors in morphine-induced antinociception in the nucleus accumbens of rats.
    Neuroscience letters, 2006, May-15, Volume: 399, Issue:1-2

    Topics: Analgesics, Opioid; Animals; Male; Morphine; Naloxone; Naltrexone; Nucleus Accumbens; Pain; Physical Stimulation; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu

2006
The involvement of endogenous opioid mechanisms in the antinociceptive effects induced by antidepressant drugs, desipramine and trimipramine.
    Pharmacology, biochemistry, and behavior, 2006, Volume: 83, Issue:4

    Topics: Analgesics; Animals; Antidepressive Agents; Desipramine; Male; Mice; Morphine; Naloxone; Naltrexone; Receptors, Opioid; Receptors, Opioid, delta; Trimipramine

2006
Role of kappa- and delta-opioid receptors in the antinociceptive effect of oxytocin in formalin-induced pain response in mice.
    Regulatory peptides, 2006, Jul-15, Volume: 135, Issue:1-2

    Topics: Analgesics; Animals; Behavior; Calcium Channel Blockers; Dose-Response Relationship, Drug; Formaldehyde; Mice; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Nimodipine; Oxytocin; Pain; Random Allocation; Receptors, Opioid, delta; Receptors, Opioid, kappa

2006
Potent in vivo antinociception and opioid receptor preference of the novel analogue [Dmt1]endomorphin-1.
    Pharmacology, biochemistry, and behavior, 2006, Volume: 84, Issue:2

    Topics: Analgesia; Animals; Brain; Guinea Pigs; Ileum; Injections, Intraventricular; Male; Mice; Naloxone; Naltrexone; Oligopeptides; Pain; Pain Measurement; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord; Tail; Vas Deferens

2006
Atypical anxiolytic-like response to naloxone in benzodiazepine-resistant 129S2/SvHsd mice: role of opioid receptor subtypes.
    Psychopharmacology, 2006, Volume: 187, Issue:3

    Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Drug Resistance; Male; Maze Learning; Mice; Mice, Inbred C57BL; Naloxone; Naltrexone; Opioid Peptides; Receptors, Opioid; Species Specificity

2006
The effects of endomorphins and diprotin A on striatal dopamine release induced by electrical stimulation-an in vitro superfusion study in rats.
    Neurochemistry international, 2006, Volume: 49, Issue:7

    Topics: Animals; Corpus Striatum; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Dopamine; Electric Stimulation; Infusion Pumps; Male; Naloxone; Naltrexone; Narcotic Antagonists; Neural Pathways; Oligopeptides; Organ Culture Techniques; Presynaptic Terminals; Radioligand Assay; Rats; Rats, Wistar; Substantia Nigra; Synaptic Transmission

2006
Expression and localization of delta-, kappa-, and mu-opioid receptors in human spermatozoa and implications for sperm motility.
    The Journal of clinical endocrinology and metabolism, 2006, Volume: 91, Issue:12

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adult; Analgesics, Opioid; Humans; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sperm Motility; Spermatozoa; Tissue Distribution

2006
Involvement of opioid receptors in oxytocin-induced antinociception in the nucleus accumbens of rats.
    The journal of pain, 2007, Volume: 8, Issue:1

    Topics: Analgesics; Animals; Hot Temperature; Male; Microinjections; Naloxone; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Oxytocin; Pain Measurement; Physical Stimulation; Rats; Rats, Wistar; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu

2007
Activators of potassium M currents have anticonvulsant actions in two rat models of encephalitis.
    European journal of pharmacology, 2007, Jan-19, Volume: 555, Issue:1

    Topics: Aminopyridines; Analgesics; Animals; Anticonvulsants; Borna Disease; Encephalitis, Viral; Herpes Simplex; Herpesvirus 1, Human; Male; Naloxone; Naltrexone; Narcotic Antagonists; Potassium; Rats; Rats, Inbred Lew; Receptors, Opioid, delta; Seizures; Substance Withdrawal Syndrome

2007
Negative inotropic and chronotropic effects of delta-opioid receptor antagonists are mediated via non-opioid receptors.
    Bulletin of experimental biology and medicine, 2006, Volume: 141, Issue:4

    Topics: Animals; Blood Pressure; Cardiotonic Agents; Ligands; Myocardial Contraction; Myocardium; Naloxone; Naltrexone; Perfusion; Rats; Rats, Wistar; Receptors, Opioid; Receptors, Opioid, delta; Ventricular Dysfunction, Left

2006
Daily increase of fat ingestion mediated via mu-opioid receptor signaling pathway.
    Biomedical research (Tokyo, Japan), 2006, Volume: 27, Issue:6

    Topics: Animals; Appetite Regulation; Corn Oil; Feeding Behavior; Male; Naloxone; Naltrexone; Narcotic Antagonists; Polysaccharides, Bacterial; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Signal Transduction

2006
Involvement of mu1-opioid receptor on oxycodone-induced antinociception in diabetic mice.
    European journal of pharmacology, 2007, Apr-10, Volume: 560, Issue:2-3

    Topics: Analgesics, Opioid; Animals; Diabetes Mellitus, Experimental; Male; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Oxycodone; Receptors, Opioid, mu; Streptozocin

2007
Effect of beta-endorphin on production of antibodies and IL-4 under conditions of opioid receptor blockade.
    Bulletin of experimental biology and medicine, 2006, Volume: 142, Issue:2

    Topics: Animals; Antibody Formation; beta-Endorphin; Dose-Response Relationship, Drug; Hypersensitivity, Delayed; Interleukin-4; Lymphocyte Activation; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Phytohemagglutinins

2006
Attenuation of vascular permeability by methylnaltrexone: role of mOP-R and S1P3 transactivation.
    American journal of respiratory cell and molecular biology, 2007, Volume: 37, Issue:2

    Topics: Analgesics, Opioid; Animals; Capillary Permeability; Cells, Cultured; Electrophysiology; Endothelial Cells; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Humans; Intracellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Protein Serine-Threonine Kinases; Quaternary Ammonium Compounds; Receptors, Lysosphingolipid; Receptors, Opioid, mu; rho-Associated Kinases; rhoA GTP-Binding Protein; RNA, Small Interfering; Thrombin; Transcriptional Activation

2007
[Role of kappa-opioid receptors in the regulation of cardiac resistance to arrhythmogenic effects of ischemia and reperfusion].
    Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2006, Volume: 92, Issue:12

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Myocardial Reperfusion Injury; Myocardium; Naloxone; Naltrexone; Piperazines; Pyrrolidines; Quaternary Ammonium Compounds; Rats; Rats, Wistar; Receptors, Opioid, kappa

2006
Structural characterization of anhydrous naloxone- and naltrexone hydrochloride by high resolution laboratory X-ray powder diffraction and thermal analysis.
    Journal of pharmaceutical sciences, 2007, Volume: 96, Issue:12

    Topics: Calorimetry, Differential Scanning; Crystallization; Crystallography, X-Ray; Desiccation; Differential Thermal Analysis; Hydrogen Bonding; Models, Molecular; Molecular Structure; Naloxone; Naltrexone; Narcotic Antagonists; Powder Diffraction; Technology, Pharmaceutical; Temperature; Water

2007
Effects of loperamide on mechanical allodynia induced by herpes simplex virus type-1 in mice.
    Journal of pharmacological sciences, 2007, Volume: 104, Issue:3

    Topics: Analgesics, Opioid; Animals; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Drug Tolerance; Female; Foot; Herpes Simplex; Herpesvirus 1, Human; Injections; Injections, Subcutaneous; Loperamide; Mice; Mice, Inbred C57BL; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Physical Stimulation

2007
The neural pathway of galanin in the hypothalamic arcuate nucleus of rats: activation of beta-endorphinergic neurons projecting to periaqueductal gray matter.
    Journal of neuroscience research, 2007, Aug-15, Volume: 85, Issue:11

    Topics: Animals; Arcuate Nucleus of Hypothalamus; beta-Endorphin; Fluorescent Antibody Technique; Galanin; Hindlimb; Hot Temperature; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Neural Pathways; Neurons; Pain; Periaqueductal Gray; Physical Stimulation; Rats; Rats, Wistar

2007
A tarantula peptide against pain via ASIC1a channels and opioid mechanisms.
    Nature neuroscience, 2007, Volume: 10, Issue:8

    Topics: Acid Sensing Ion Channels; Analgesics; Animals; Area Under Curve; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Enkephalins; Membrane Proteins; Mice; Mice, Knockout; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Nerve Tissue Proteins; Neurons; Pain; Pain Measurement; Peptides; Protein Precursors; Reaction Time; Sodium Channels; Spider Venoms; Spinal Cord; Time Factors

2007
Increase in diazepam binding inhibitor expression by sustained morphine exposure is mediated via mu-opioid receptors in primary cultures of mouse cerebral cortical neurons.
    Journal of neuroscience research, 2007, Volume: 85, Issue:13

    Topics: Analysis of Variance; Animals; Cells, Cultured; Cerebral Cortex; Diazepam Binding Inhibitor; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; Enzyme Inhibitors; Gene Expression Regulation; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Neurons; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors

2007
Two-photon excitation fluorescence cross-correlation assay for ligand-receptor binding: cell membrane nanopatches containing the human micro-opioid receptor.
    Analytical chemistry, 2007, Sep-01, Volume: 79, Issue:17

    Topics: Animals; Cell Line; Cell Membrane; Cross-Linking Reagents; Enkephalin, Leucine; Fluorescein; Humans; Ligands; Molecular Structure; Naloxone; Naltrexone; Nanostructures; Narcotic Antagonists; Photons; Quantum Dots; Receptors, Opioid; Solutions; Spodoptera; Titrimetry

2007
Naloxone rapidly evokes endogenous kappa opioid receptor-mediated hyperalgesia in naïve mice pretreated briefly with GM1 ganglioside or in chronic morphine-dependent mice.
    Brain research, 2007, Sep-05, Volume: 1167

    Topics: Analgesics, Opioid; Animals; Chronic Disease; Dipeptides; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Synergism; G(M1) Ganglioside; Hyperalgesia; Male; Mice; Morphine; Morphine Dependence; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Opioid Peptides; Receptors, Opioid, kappa; Substance Withdrawal Syndrome

2007
A select set of opioid ligands induce up-regulation by promoting the maturation and stability of the rat kappa-opioid receptor in human embryonic kidney 293 cells.
    The Journal of pharmacology and experimental therapeutics, 2007, Volume: 323, Issue:2

    Topics: Animals; Benzeneacetamides; Brefeldin A; Cells, Cultured; Cycloheximide; Diprenorphine; Humans; Ligands; Naloxone; Naltrexone; Pyrrolidines; Rats; Receptors, Opioid, kappa; RNA, Messenger; Transfection; Up-Regulation

2007
Intramuscular administration of morphine reduces mustard-oil-induced craniofacial-muscle pain behavior in lightly anesthetized rats.
    European journal of pain (London, England), 2008, Volume: 12, Issue:3

    Topics: Analgesics; Anesthesia, General; Animals; Inflammation; Injections; Injections, Intramuscular; Male; Masseter Muscle; Morphine; Mustard Plant; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Pain; Plant Oils; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Single-Blind Method; Somatostatin

2008
Use of preproenkephalin knockout mice and selective inhibitors of enkephalinases to investigate the role of enkephalins in various behaviours.
    Psychopharmacology, 2008, Volume: 196, Issue:2

    Topics: Analysis of Variance; Animals; Behavior, Animal; CD13 Antigens; Disulfides; Dose-Response Relationship, Drug; Enkephalins; Enzyme Inhibitors; Injections, Intravenous; Mice; Mice, Inbred DBA; Mice, Knockout; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Neprilysin; Phenylalanine; Protein Precursors; Swimming

2008
Morphine postconditioning protects against reperfusion injury in the isolated rat hearts.
    The Journal of surgical research, 2008, Volume: 145, Issue:2

    Topics: Analgesics, Opioid; Animals; Anti-Arrhythmia Agents; Cardiotonic Agents; Decanoic Acids; Dose-Response Relationship, Drug; Hydroxy Acids; In Vitro Techniques; Ischemic Preconditioning, Myocardial; Male; Morphine; Myocardial Infarction; Naloxone; Naltrexone; Narcotic Antagonists; Potassium Channels; Rats; Rats, Sprague-Dawley; Reperfusion Injury

2008
In vivo characterization of the effects of human hemokinin-1 and human hemokinin-1(4-11), mammalian tachykinin peptides, on the modulation of pain in mice.
    Brain, behavior, and immunity, 2008, Volume: 22, Issue:6

    Topics: Analgesics; Animals; Benzamides; Bicuculline; Dose-Response Relationship, Drug; GABA Antagonists; Humans; Injections, Intraventricular; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Neurokinin-1 Receptor Antagonists; Pain; Pain Measurement; Peptide Fragments; Piperidines; Receptors, Neurokinin-2; Tachykinins; Tropanes

2008
Acute and chronic heroin dependence in mice: contribution of opioid and excitatory amino acid receptors.
    European journal of pharmacology, 2008, May-31, Volume: 586, Issue:1-3

    Topics: Acute Disease; Animals; Behavior, Animal; Benzylidene Compounds; Chronic Disease; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Heroin Dependence; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Substance Withdrawal Syndrome; Time Factors

2008
High voluntary alcohol consumption, in experimental liver cirrhosis is hardly responsive to opioid antagonist treatment.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2008, Volume: 59, Issue:1

    Topics: Alcohol Drinking; Animals; Behavior, Animal; Bilirubin; Brain; Disease Models, Animal; Drinking; Liver Cirrhosis; Male; Naloxone; Naltrexone; Narcotic Antagonists; Prothrombin Time; Radioligand Assay; Rats; Rats, Wistar; Receptors, Opioid, mu; Thioacetamide; Time Factors

2008
Mu-opioid receptor in the nucleus submedius: involvement in opioid-induced inhibition of mirror-image allodynia in a rat model of neuropathic pain.
    Neurochemical research, 2008, Volume: 33, Issue:10

    Topics: Animals; Behavior, Animal; Disease Models, Animal; Enkephalin, Leucine-2-Alanine; Hyperalgesia; Ligation; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Neuralgia; Oligopeptides; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Spinal Nerves; Thalamic Nuclei

2008
Possible involvement of dynorphin A release via mu1-opioid receptor on supraspinal antinociception of endomorphin-2.
    Peptides, 2008, Volume: 29, Issue:9

    Topics: Analgesics; Animals; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Immune Sera; Injections, Intraventricular; Male; Mice; Naloxone; Naltrexone; Oligopeptides; Protein Precursors; Receptors, Opioid, kappa; Receptors, Opioid, mu

2008
Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll-like receptor 4 (TLR4).
    The European journal of neuroscience, 2008, Volume: 28, Issue:1

    Topics: Animals; Behavior, Animal; Biomarkers; Cell Line; Humans; Injections, Spinal; Male; Microglia; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Signal Transduction; Toll-Like Receptor 4

2008
Morphine attenuates the expression of sensitization to ethanol, but opioid antagonists do not.
    Neuroscience, 2008, Oct-28, Volume: 156, Issue:4

    Topics: Analgesics, Opioid; Analysis of Variance; Animals; Autoradiography; Behavior, Animal; Brain; Central Nervous System Depressants; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Ethanol; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Protein Binding; Rats; Rats, Wistar; Tritium

2008
The effects of endomorphins on striatal [3H]GABA release induced by electrical stimulation: an in vitro superfusion study in rats.
    Neurochemical research, 2009, Volume: 34, Issue:5

    Topics: Animals; Corpus Striatum; Dipeptidyl-Peptidase IV Inhibitors; Electric Stimulation; gamma-Aminobutyric Acid; Male; Naloxone; Naltrexone; Oligopeptides; Perfusion; Rats; Rats, Wistar; Receptors, Opioid, mu; Tritium

2009
Antinociceptive action of 4-methyl-5-trifluoromethyl-5-hydroxy-4, 5-dihydro-1H-pyrazole methyl ester in models of inflammatory pain in mice.
    Life sciences, 2008, Nov-21, Volume: 83, Issue:21-22

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Dipyrone; Freund's Adjuvant; Indomethacin; Inflammation; Male; Mice; Morphine; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Pain, Postoperative; Postural Balance; Pyrazoles; Stomach Ulcer

2008
[Analysis of central mechanisms involved in gastric mucosal integrity].
    Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology, 2008, Volume: 10, Issue:3

    Topics: Animals; Arachidonic Acids; beta-Endorphin; Clonidine; Endocannabinoids; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Ethanol; Excitatory Amino Acids; Gastric Mucosa; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Neurotransmitter Agents; Nociceptin; Oligopeptides; Opioid Peptides; Oxazoles; Polyunsaturated Alkamides; Rats; Rats, Wistar; Receptors, Opioid; Rilmenidine; Stomach Ulcer

2008
Role of opioid system in modulation of pain sensitivity under conditons of low and high environmental temperature.
    Bulletin of experimental biology and medicine, 2008, Volume: 145, Issue:6

    Topics: Analgesics, Opioid; Animals; Cold Temperature; Hot Temperature; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Pain Threshold; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu

2008
Evidence for the involvement of the opioid system in the antidepressant-like effect of folic acid in the mouse forced swimming test.
    Behavioural brain research, 2009, Jun-08, Volume: 200, Issue:1

    Topics: Analgesics, Opioid; Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Disease Models, Animal; Dizocilpine Maleate; Drug Combinations; Excitatory Amino Acid Antagonists; Exploratory Behavior; Folic Acid; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Swimming

2009
Neutral antagonist activity of naltrexone and 6beta-naltrexol in naïve and opioid-dependent C6 cells expressing a mu-opioid receptor.
    British journal of pharmacology, 2009, Volume: 156, Issue:7

    Topics: Adenylyl Cyclases; Animals; Binding, Competitive; Cell Line; Cell Line, Tumor; Cyclic AMP; Drug Inverse Agonism; Drug Partial Agonism; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Humans; Morphine; Naloxone; Naltrexone; Peptide Fragments; Piperidines; Radioligand Assay; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Somatostatin

2009
Intravenous self-administration of etonitazene alone and combined with cocaine in rhesus monkeys: comparison with heroin and antagonism by naltrexone and naloxonazine.
    Psychopharmacology, 2009, Volume: 204, Issue:3

    Topics: Animals; Benzimidazoles; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Drug Interactions; Female; Heroin; Injections, Intravenous; Macaca mulatta; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Receptors, Opioid, mu; Reinforcement, Psychology; Self Administration; Substance Abuse, Intravenous

2009
Involvement of exon 11-associated variants of the mu opioid receptor MOR-1 in heroin, but not morphine, actions.
    Proceedings of the National Academy of Sciences of the United States of America, 2009, Mar-24, Volume: 106, Issue:12

    Topics: Alternative Splicing; Analgesia; Animals; Exons; Gastrointestinal Transit; Gene Targeting; Heroin; Heterozygote; Mice; Mice, Knockout; Morphine; Mutation; Naloxone; Naltrexone; Receptors, Opioid, mu

2009
Morphine-6beta-glucuronide rapidly increases pain sensitivity independently of opioid receptor activity in mice and humans.
    Anesthesiology, 2009, Volume: 110, Issue:6

    Topics: Adolescent; Adult; Animals; Dizocilpine Maleate; Female; Humans; Hyperalgesia; Male; Mice; Mice, Knockout; Morphine Derivatives; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Reaction Time; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Young Adult

2009
Selective mu- and kappa-opioid receptor antagonists administered into the nucleus accumbens interfere with rapid tolerance to ethanol in rats.
    Psychopharmacology, 2009, Volume: 206, Issue:1

    Topics: Animals; Drug Tolerance; Ethanol; Male; Microinjections; Naloxone; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Rats; Rats, Wistar; Receptors, Opioid, kappa; Receptors, Opioid, mu

2009
Role of the opioid system in incentive downshift situations.
    Neurobiology of learning and memory, 2009, Volume: 92, Issue:3

    Topics: Analgesics, Opioid; Animals; Conditioning, Classical; Dietary Sucrose; Drinking Behavior; Enkephalin, D-Penicillamine (2,5)-; Extinction, Psychological; Feeding Behavior; Female; Goals; Male; Motivation; Naloxone; Naltrexone; Narcotic Antagonists; Random Allocation; Rats; Rats, Long-Evans; Receptors, Opioid, mu; Taste Perception; Time Factors

2009
Prodynorphin gene deficiency potentiates nalbuphine-induced behavioral sensitization and withdrawal syndrome in mice.
    Drug and alcohol dependence, 2009, Sep-01, Volume: 104, Issue:1-2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Area Under Curve; Blotting, Western; Dopamine; Enkephalins; Gene Expression; Genes, fos; Mice; Mice, Knockout; Microdialysis; Motor Activity; Nalbuphine; Naloxone; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Protein Precursors; Receptors, Opioid, kappa; Reverse Transcriptase Polymerase Chain Reaction; Substance Withdrawal Syndrome

2009
The antinociceptive properties of reboxetine in acute pain.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2009, Volume: 19, Issue:10

    Topics: Adrenergic Antagonists; Analgesics; Animals; Antidepressive Agents; Clonidine; Disease Models, Animal; Drug Interactions; Male; Mice; Mice, Inbred ICR; Morphine; Morpholines; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Reboxetine; Receptors, Opioid, mu

2009
P-glycoprotein is not involved in the differential oral potency of naloxone and naltrexone.
    Fundamental & clinical pharmacology, 2009, Volume: 23, Issue:5

    Topics: Acridines; Administration, Oral; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Biological Transport; Blotting, Western; Caco-2 Cells; Electric Impedance; Humans; Microscopy, Electron, Transmission; Molecular Structure; Naloxone; Naltrexone; Narcotic Antagonists; Tetrahydroisoquinolines

2009
Opioid antagonists block the acquisition of ethanol-mediated conditioned tactile preference in infant rats.
    Alcohol (Fayetteville, N.Y.), 2009, Volume: 43, Issue:5

    Topics: Alcohol Drinking; Alcoholic Intoxication; Animals; Animals, Newborn; Conditioning, Classical; Ethanol; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Touch

2009
Association of increased pain threshold by noise with central opioid neurons.
    The Chinese journal of physiology, 2009, Apr-30, Volume: 52, Issue:2

    Topics: Analgesia; Animals; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Noise; Opioid Peptides; Pain Measurement; Pain Threshold; Receptors, Opioid, delta; Receptors, Opioid, mu; Stress, Physiological

2009
A prolonged protein kinase C-mediated, opioid-related antinociceptive effect of st John's Wort in mice.
    The journal of pain, 2010, Volume: 11, Issue:2

    Topics: Acetic Acid; Analgesics; Analgesics, Opioid; Animals; Anthracenes; Chromatography, High Pressure Liquid; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Administration Schedule; Drug Compounding; Hypericum; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Pain Threshold; Perylene; Phorbol Esters; Phytotherapy; Protein Kinase C; Quercetin; Somatostatin; Spectrometry, Mass, Electrospray Ionization; Statistics, Nonparametric; Time Factors

2010
Effect of opioid compounds on feeding and activity of the cockroach, Periplaneta americana.
    Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 2010, Volume: 151, Issue:3

    Topics: Analgesics, Opioid; Animals; Behavior, Animal; Cockroaches; Eating; Female; Male; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, kappa; Receptors, Opioid, mu; Water Loss, Insensible

2010
Antinociceptive effects of galanin in the central nucleus of amygdala of rats, an involvement of opioid receptors.
    Brain research, 2010, Mar-12, Volume: 1320

    Topics: Amygdala; Animals; Galanin; Hindlimb; Hot Temperature; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Physical Stimulation; Rats; Rats, Wistar; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Time Factors

2010
Nucleus accumbens mu opioid receptors mediate immediate postictal decrease in locomotion after an amygdaloid kindled seizure in rats.
    Epilepsy & behavior : E&B, 2010, Volume: 17, Issue:2

    Topics: Amygdala; Animals; Epilepsy; Kindling, Neurologic; Locomotion; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Rats; Rats, Long-Evans; Receptors, Opioid, mu; Seizures

2010
Emerging new therapeutic options for the management of opioid induced constipation.
    Journal of pain & palliative care pharmacotherapy, 2010, Volume: 24, Issue:1

    Topics: Alprostadil; Analgesics, Opioid; Constipation; Delayed-Action Preparations; Drug Therapy, Combination; Humans; Laxatives; Lubiprostone; Naloxone; Naltrexone; Narcotic Antagonists; Oxycodone; Quaternary Ammonium Compounds

2010
Evidence for a role of opioids in epoxyeicosatrienoic acid-induced cardioprotection in rat hearts.
    American journal of physiology. Heart and circulatory physiology, 2010, Volume: 298, Issue:6

    Topics: 8,11,14-Eicosatrienoic Acid; Analgesics, Opioid; Animals; Disease Models, Animal; GTP-Binding Protein alpha Subunits, Gi-Go; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Somatostatin

2010
Alteration of intravenous nicotine self-administration by opioid receptor agonist and antagonists in rats.
    Psychopharmacology, 2010, Volume: 210, Issue:2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Dose-Response Relationship, Drug; Feeding Behavior; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nicotine; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Self Administration; Tobacco Use Disorder

2010
The diverse clinical uses of opioid receptor drugs.
    Journal of psychosocial nursing and mental health services, 2010, Volume: 48, Issue:5

    Topics: Analgesics, Opioid; Buprenorphine; Drug Combinations; Humans; Methadone; Naloxone; Naltrexone; Narcotic Antagonists

2010
The μ-opioid receptor variant N190K is unresponsive to peptide agonists yet can be rescued by small-molecule drugs.
    Molecular pharmacology, 2010, Volume: 78, Issue:5

    Topics: Amino Acid Substitution; Black or African American; Cell Line; Cholesterol, HDL; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Female; Genes, Reporter; Genotype; Humans; Luciferases; Mutagenesis, Site-Directed; Mutation, Missense; Naloxone; Naltrexone; Narcotic Antagonists; Opioid Peptides; Peptides; Polymorphism, Single Nucleotide; Protein Isoforms; Protein Transport; Radioligand Assay; Receptors, Opioid, mu; Signal Transduction; White People

2010
Peripheral antinociceptive effects of the cyclic endomorphin-1 analog c[YpwFG] in a mouse visceral pain model.
    Peptides, 2010, Volume: 31, Issue:11

    Topics: Analgesics; Animals; Injections, Intraperitoneal; Injections, Intraventricular; Injections, Subcutaneous; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain; Peptides, Cyclic; Receptors, Opioid, mu

2010
Dark chocolate receptors: epicatechin-induced cardiac protection is dependent on delta-opioid receptor stimulation.
    American journal of physiology. Heart and circulatory physiology, 2010, Volume: 299, Issue:5

    Topics: Animals; Cacao; Catechin; Decanoic Acids; Dose-Response Relationship, Drug; Hydroxy Acids; Male; Mice; Mice, Inbred C57BL; Models, Animal; Myocardial Infarction; Myocardial Reperfusion Injury; Naloxone; Naltrexone; Potassium Channel Blockers; Receptors, Cell Surface; Receptors, Opioid, delta

2010
Acupuncture inhibits GABA neuron activity in the ventral tegmental area and reduces ethanol self-administration.
    Alcoholism, clinical and experimental research, 2010, Volume: 34, Issue:12

    Topics: Action Potentials; Acupuncture Therapy; Animals; Drug Interactions; Electric Stimulation; Ethanol; gamma-Aminobutyric Acid; Male; Naloxone; Naltrexone; Neurons; Rats; Rats, Wistar; Self Administration; Sucrose; Tail; Ventral Tegmental Area

2010
Effect of ultra-rapid opiate detoxification on withdrawal syndrome.
    Journal of addictive diseases, 2010, Volume: 29, Issue:4

    Topics: Adult; Anesthesia, General; Female; Humans; Male; Naloxone; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Substance Withdrawal Syndrome

2010
Dorsal hippocampal opioidergic system modulates anxiety-like behaviors in adult male Wistar rats.
    Psychiatry and clinical neurosciences, 2010, Volume: 64, Issue:6

    Topics: Analgesics, Opioid; Animals; Anxiety; CA1 Region, Hippocampal; Disease Models, Animal; Enkephalin, D-Penicillamine (2,5)-; Male; Maze Learning; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu

2010
The antidepressant-like effect of human opiorphin via opioid-dependent pathways in mice.
    Neuroscience letters, 2011, Feb-04, Volume: 489, Issue:2

    Topics: Animals; Antidepressive Agents; Dose-Response Relationship, Drug; Habituation, Psychophysiologic; Humans; Injections, Intraventricular; Male; Mice; Motor Activity; Naloxone; Naltrexone; Oligopeptides; Receptors, Opioid, delta; Receptors, Opioid, mu; Salivary Proteins and Peptides; Signal Transduction

2011
Endogenously released opioids mediate meal-induced gastric relaxation via peripheral mu-opioid receptors.
    Alimentary pharmacology & therapeutics, 2011, Volume: 33, Issue:5

    Topics: Adult; Analgesics, Opioid; Analysis of Variance; Eating; Female; Food; Humans; Male; Naloxone; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Receptors, Opioid, mu; Satiation; Stomach

2011
μ-Opioid receptors in the nucleus accumbens shell region mediate the effects of amphetamine on inhibitory control but not impulsive choice.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011, Jan-05, Volume: 31, Issue:1

    Topics: Amphetamine; Analgesics, Opioid; Animals; Attention; Central Nervous System Stimulants; Choice Behavior; Conditioning, Operant; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Impulsive Behavior; Inhibition, Psychological; Male; Motivation; Naloxone; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Peptides; Rats; Rats, Wistar; Reaction Time; Receptors, Opioid, mu; Reinforcement Schedule

2011
Morphine postconditioning attenuates ICAM-1 expression on endothelial cells.
    Journal of Korean medical science, 2011, Volume: 26, Issue:2

    Topics: Animals; Benzophenanthridines; Endothelial Cells; Endothelium, Vascular; Humans; Intercellular Adhesion Molecule-1; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Protein Isoforms; Protein Kinase C; Receptors, Opioid; Reperfusion Injury; Signal Transduction; Umbilical Veins

2011
Delayed postoperative latent pain sensitization revealed by the systemic administration of opioid antagonists in mice.
    European journal of pharmacology, 2011, Apr-25, Volume: 657, Issue:1-3

    Topics: Animals; Dizocilpine Maleate; Dynorphins; Hyperalgesia; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Pain Threshold; Piperidines; Postoperative Complications; Reaction Time; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa; Remifentanil; Spinal Cord

2011
Analgesic tone conferred by constitutively active mu opioid receptors in mice lacking β-arrestin 2.
    Molecular pain, 2011, Apr-12, Volume: 7

    Topics: Animals; Arrestins; beta-Arrestin 2; beta-Arrestins; Electrophysiology; Female; Ganglia, Spinal; Male; Mice; Mice, Mutant Strains; Naloxone; Naltrexone; Pain Measurement; Peptide Fragments; Receptors, Opioid, mu; Somatostatin

2011
Multiple opioid receptors mediate the hypotensive response induced by central 5-HT(3) receptor stimulation.
    Neuropeptides, 2011, Volume: 45, Issue:3

    Topics: Animals; Biguanides; Blood Pressure; Heart Rate; Hypotension; Male; Naloxone; Naltrexone; Narcotic Antagonists; Ondansetron; Rats; Rats, Wistar; Receptors, Opioid; Receptors, Serotonin, 5-HT3; Serotonin 5-HT3 Receptor Agonists; Serotonin 5-HT3 Receptor Antagonists

2011
The action of a synthetic derivative of Met5-enkephalin-Arg6-Phe7 on behavioral and endocrine responses.
    Peptides, 2011, Volume: 32, Issue:8

    Topics: Animals; Behavior, Animal; Enkephalin, Methionine; Enkephalins; Hypothalamo-Hypophyseal System; Male; Mice; Mice, Inbred Strains; Naloxone; Naltrexone; Oligopeptides; Pituitary-Adrenal System

2011
Effect of opioid receptor blockade on acetaldehyde self-administration and ERK phosphorylation in the rat nucleus accumbens.
    Alcohol (Fayetteville, N.Y.), 2011, Volume: 45, Issue:8

    Topics: Acetaldehyde; Animals; Enzyme Activation; Ethanol; Extracellular Signal-Regulated MAP Kinases; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Phosphorylation; Rats; Rats, Wistar; Receptors, Opioid, mu; Reinforcement, Psychology; Saccharin; Self Administration

2011
Central administration of neuronostatin induces antinociception in mice.
    Peptides, 2011, Volume: 32, Issue:9

    Topics: Acute Pain; Analgesics; Animals; Dose-Response Relationship, Drug; Immunohistochemistry; Infusions, Intraventricular; Male; Melanocyte-Stimulating Hormones; Mice; Models, Animal; Naloxone; Naltrexone; Narcotic Antagonists; Nociception; Peptide Hormones; Periaqueductal Gray; Proto-Oncogene Proteins c-fos; Receptor, Melanocortin, Type 3; Receptor, Melanocortin, Type 4

2011
Opioid-like antinociceptive effects of oral administration of a lectin purified from the seeds of Canavalia brasiliensis.
    Fundamental & clinical pharmacology, 2013, Volume: 27, Issue:2

    Topics: Administration, Oral; Analgesics; Analgesics, Opioid; Animals; Canavalia; Mice; Morphinans; Naloxone; Naltrexone; Nociception; Pain Measurement; Plant Lectins; Receptors, Opioid, delta; Receptors, Opioid, kappa; Seeds

2013
YFa and analogs: investigation of opioid receptors in smooth muscle contraction.
    World journal of gastroenterology, 2011, Oct-28, Volume: 17, Issue:40

    Topics: Acetylcholine; Analgesics, Opioid; Animals; Cholinergic Agonists; Dynorphins; Enkephalin, Methionine; Guinea Pigs; Ileum; Male; Mice; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists; Neurotransmitter Agents; Oligopeptides; Receptors, Opioid; Vas Deferens

2011
The relationship between naloxone-induced cortisol and delta opioid receptor availability in mesolimbic structures is disrupted in alcohol-dependent subjects.
    Addiction biology, 2013, Volume: 18, Issue:1

    Topics: Adrenocorticotropic Hormone; Adult; Alcoholism; Area Under Curve; Case-Control Studies; Dose-Response Relationship, Drug; Female; Humans; Hydrocortisone; Hypothalamo-Hypophyseal System; Ligands; Limbic System; Linear Models; Male; Middle Aged; Naloxone; Naltrexone; Narcotic Antagonists; Pituitary-Adrenal System; Positron-Emission Tomography; Receptors, Opioid, delta; Stress, Psychological; Young Adult

2013
Synthesis and biological evaluation of naloxone and naltrexone-derived hybrid opioids.
    Medicinal chemistry (Shariqah (United Arab Emirates)), 2012, Volume: 8, Issue:4

    Topics: Amino Acid Sequence; Analgesics, Opioid; Binding Sites; Inhibitory Concentration 50; Microscopy, Electron, Scanning; Molecular Sequence Data; Molecular Structure; Naloxone; Naltrexone; Narcotic Antagonists; Peptides; Protein Binding; Receptors, Opioid; Solid-Phase Synthesis Techniques

2012
Cathepsin E induces itch-related response through the production of endothelin-1 in mice.
    European journal of pharmacology, 2012, Jul-05, Volume: 686, Issue:1-3

    Topics: Animals; Behavior, Animal; Cathepsin E; Cells, Cultured; Endothelin Receptor Antagonists; Endothelin-1; Histamine Release; Keratinocytes; Male; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Narcotic Antagonists; Pepstatins; Peptides, Cyclic; Protease Inhibitors; Pruritus; Receptor, PAR-2; RNA, Messenger; Skin

2012
κ-Opioid receptors within the nucleus accumbens shell mediate pair bond maintenance.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012, May-16, Volume: 32, Issue:20

    Topics: Aggression; Animals; Arvicolinae; Autoradiography; Brain; Corticosterone; Dose-Response Relationship, Drug; Female; Male; Microinjections; Naloxone; Naltrexone; Nucleus Accumbens; Pair Bond; Peptide Fragments; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sex Characteristics; Somatostatin; Testosterone

2012
Centrally administered apelin-13 induces depression-like behavior in mice.
    Brain research bulletin, 2012, Sep-01, Volume: 88, Issue:6

    Topics: Amino Acid Sequence; Animals; Apelin Receptors; Corticotropin-Releasing Hormone; Depression; Injections; Injections, Intraventricular; Intercellular Signaling Peptides and Proteins; Male; Mice; Motor Activity; Naloxone; Naltrexone; Peptide Fragments; Receptor, Angiotensin, Type 1; Receptors, Corticotropin-Releasing Hormone; Receptors, G-Protein-Coupled; Receptors, Opioid, kappa; Rotarod Performance Test; Single-Blind Method

2012
Supraspinal antinociceptive effect of apelin-13 in a mouse visceral pain model.
    Peptides, 2012, Volume: 37, Issue:1

    Topics: Acetic Acid; Analgesics; Analgesics, Opioid; Animals; Drug Synergism; Injections, Intraperitoneal; Injections, Intraventricular; Injections, Spinal; Intercellular Signaling Peptides and Proteins; Male; Mice; Morphine; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Nociception; Visceral Pain

2012
Non-analgesic effects of opioids: management of opioid-induced constipation by peripheral opioid receptor antagonists: prevention or withdrawal?
    Current pharmaceutical design, 2012, Volume: 18, Issue:37

    Topics: Age Factors; Analgesics, Opioid; Constipation; Defecation; Drug Combinations; Gastrointestinal Tract; Humans; Laxatives; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Predictive Value of Tests; Prevalence; Quaternary Ammonium Compounds; Receptors, Opioid; Risk Factors

2012
A combination of buprenorphine and naltrexone blocks compulsive cocaine intake in rodents without producing dependence.
    Science translational medicine, 2012, Aug-08, Volume: 4, Issue:146

    Topics: Animals; Buprenorphine; Cocaine; Cocaine-Related Disorders; Male; Naloxone; Naltrexone; Rats; Rats, Wistar; Substance Withdrawal Syndrome

2012
Analgesic properties of chimeric peptide based on morphiceptin and PFRTic-amide.
    Regulatory peptides, 2012, Nov-10, Volume: 179, Issue:1-3

    Topics: Analgesia; Analgesics, Opioid; Animals; Arginine; Dose-Response Relationship, Drug; Endorphins; Guinea Pigs; Male; Mice; Morphinans; Naloxone; Naltrexone; Neuropeptides; Opioid Peptides; Proline; Receptors, Neuropeptide; Tetrahydroisoquinolines; Time Factors

2012
Opioid dependence.
    American family physician, 2012, Sep-15, Volume: 86, Issue:6

    Topics: Buprenorphine; Clonidine; Evidence-Based Medicine; Humans; Inactivation, Metabolic; Methadone; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Opiate Substitution Treatment; Opioid-Related Disorders; Prognosis; Risk Factors; Substance Withdrawal Syndrome; Time Factors

2012
Spinal cord stimulation reduces hypersensitivity through activation of opioid receptors in a frequency-dependent manner.
    European journal of pain (London, England), 2013, Volume: 17, Issue:4

    Topics: Analgesics, Opioid; Animals; Hyperalgesia; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Neuralgia; Pain Measurement; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Spinal Cord; Spinal Cord Stimulation

2013
Antinociceptive action of isolated mitragynine from Mitragyna Speciosa through activation of opioid receptor system.
    International journal of molecular sciences, 2012, Volume: 13, Issue:9

    Topics: Analgesics; Animals; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Male; Mice; Mice, Inbred ICR; Mitragyna; Naloxone; Naltrexone; Narcotic Antagonists; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Opioid; Secologanin Tryptamine Alkaloids

2012
Involvement of peripheral cannabinoid and opioid receptors in β-caryophyllene-induced antinociception.
    European journal of pain (London, England), 2013, Volume: 17, Issue:5

    Topics: Animals; Cannabinoids; Endorphins; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Nociception; Pain; Pain Measurement; Polycyclic Sesquiterpenes; Receptor, Cannabinoid, CB2; Sesquiterpenes

2013
The cardiovascular effects of a chimeric opioid peptide based on morphiceptin and PFRTic-NH2.
    Peptides, 2013, Volume: 39

    Topics: Analgesics, Opioid; Animals; Blood Pressure; Bradycardia; Endorphins; Heart Rate; Hypotension; Injections, Intravenous; Injections, Intraventricular; Male; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; NG-Nitroarginine Methyl Ester; Rats; Rats, Wistar

2013
Kappa-opioid receptors mediate the antidepressant-like activity of hesperidin in the mouse forced swimming test.
    European journal of pharmacology, 2013, Jan-05, Volume: 698, Issue:1-3

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Hesperidin; Male; Mice; Naloxone; Naltrexone; Receptors, Opioid, kappa; Receptors, Purinergic P1; Swimming

2013
Opiate receptor antagonists for treatment of severe pruritus associated with advanced cholestatic liver disease.
    Journal of palliative medicine, 2013, Volume: 16, Issue:2

    Topics: Aged, 80 and over; Cholestasis; Comorbidity; Humans; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pruritus; Quality of Life; Quaternary Ammonium Compounds

2013
[Effect of opioid receptor blockade on antibody response and proliferative response under stress conditions].
    Eksperimental'naia i klinicheskaia farmakologiia, 2013, Volume: 76, Issue:1

    Topics: Animals; Antibody Formation; B-Lymphocytes; Cell Proliferation; Immobilization; Immunity, Humoral; Lymphocyte Count; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Rotation; Spleen; Stress, Physiological

2013
Differential control of opioid antinociception to thermal stimuli in a knock-in mouse expressing regulator of G-protein signaling-insensitive Gαo protein.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013, Mar-06, Volume: 33, Issue:10

    Topics: Analgesics, Opioid; Animals; Brain; Diprenorphine; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Excitatory Amino Acid Antagonists; Female; GABA Antagonists; gamma-Aminobutyric Acid; Gene Expression Regulation; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine 5'-O-(3-Thiotriphosphate); Hot Temperature; Humans; Hyperalgesia; Inhibitory Postsynaptic Potentials; Isotopes; Male; Methadone; Mice; Mice, Transgenic; Morphine; Mutation; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Oligopeptides; Pain Measurement; Patch-Clamp Techniques; Pertussis Toxin; Protein Binding; Reaction Time; RGS Proteins; Signal Transduction; Spinal Cord

2013
Rewarding effects of ethanol combined with low doses of morphine through dopamine D1 receptors.
    Journal of Nippon Medical School = Nippon Ika Daigaku zasshi, 2013, Volume: 80, Issue:1

    Topics: Analgesics, Opioid; Animals; Benzazepines; Central Nervous System Depressants; Conditioning, Psychological; Dose-Response Relationship, Drug; Ethanol; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Reward

2013
Co-activation of μ- and δ-opioid receptors elicits tolerance to morphine-induced ventilatory depression via generation of peroxynitrite.
    Respiratory physiology & neurobiology, 2013, May-01, Volume: 186, Issue:3

    Topics: Analysis of Variance; Animals; Antidotes; Drug Tolerance; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Penicillamine; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Respiratory Insufficiency; Time Factors

2013
Involvement of μ-opioid receptors in antinociceptive action of botulinum toxin type A.
    Neuropharmacology, 2013, Volume: 70

    Topics: Analgesics; Animals; Botulinum Toxins, Type A; Dose-Response Relationship, Drug; Drug Interactions; Male; Naloxone; Naltrexone; Narcotic Antagonists; Posterior Horn Cells; Proto-Oncogene Proteins c-fos; Rats; Receptors, Opioid, mu

2013
Effect of naloxone on ischemic acute kidney injury in the mouse.
    Neuropharmacology, 2013, Volume: 71

    Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Hypothalamus, Anterior; Injections, Intraperitoneal; Injections, Intraventricular; Kidney; Male; Mice; Mice, Inbred ICR; Molecular Targeted Therapy; Naloxone; Naltrexone; Narcotic Antagonists; Nerve Tissue Proteins; Neurons; Proto-Oncogene Proteins c-fos; Receptors, Opioid, mu; Renal Insufficiency; Reperfusion Injury

2013
Long-term antinociception by electroacupuncture is mediated via peripheral opioid receptors in free-moving rats with inflammatory hyperalgesia.
    European journal of pain (London, England), 2013, Volume: 17, Issue:10

    Topics: Acupuncture Analgesia; Acupuncture Points; Animals; Disease Models, Animal; Electroacupuncture; Freund's Adjuvant; Hyperalgesia; Inflammation; Male; Naloxone; Naltrexone; Pain Measurement; Rats; Rats, Wistar; Receptors, Opioid; Time

2013
Synthesis, modeling, and pharmacological evaluation of UMB 425, a mixed μ agonist/δ antagonist opioid analgesic with reduced tolerance liabilities.
    ACS chemical neuroscience, 2013, Sep-18, Volume: 4, Issue:9

    Topics: Analgesics, Opioid; Animals; CHO Cells; Computer Simulation; Cricetulus; Drug Evaluation, Preclinical; Drug Tolerance; Humans; Male; Mice; Models, Chemical; Molecular Structure; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptive Pain; Pain Measurement; Protein Binding; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship; Thebaine; Transfection

2013
A novel, potent, oral active and safe antinociceptive pyrazole targeting kappa opioid receptors.
    Neuropharmacology, 2013, Volume: 73

    Topics: Adrenergic alpha-2 Receptor Antagonists; Analgesics; Animals; Benzofurans; Diterpenes; Drug Administration Routes; Drug Evaluation, Preclinical; Idazoxan; Male; Mice; Molecular Structure; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Pyrazoles; Pyrrolidines; Radioligand Assay; Receptors, Opioid, kappa; Tritium; TRPV Cation Channels

2013
Physical presence of nor-binaltorphimine in mouse brain over 21 days after a single administration corresponds to its long-lasting antagonistic effect on κ-opioid receptors.
    The Journal of pharmacology and experimental therapeutics, 2013, Volume: 346, Issue:3

    Topics: Analgesics; Animals; Benzeneacetamides; Brain; Chromatography, High Pressure Liquid; Hot Temperature; Injections, Intraventricular; Membranes; Mice; Mice, Inbred C57BL; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Pyrrolidines; Receptors, Opioid, kappa; Reference Standards; Tandem Mass Spectrometry; Time Factors

2013
Pharmacokinetic evidence for the long-lasting effect of nor-binaltorphimine, a potent kappa opioid receptor antagonist, in mice.
    Neuroscience letters, 2013, Sep-27, Volume: 552

    Topics: Animals; Brain; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, kappa; Time Factors

2013
Different types of opioid receptors involved in the suppression of LH secretion in lactating sheep.
    Animal reproduction science, 2013, Volume: 141, Issue:1-2

    Topics: Animals; Female; Gene Expression Regulation; Guanidines; Lactation; Luteinizing Hormone; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Sheep

2013
Mechanisms underlying the antinociceptive effect of mangiferin in the formalin test.
    European journal of pharmacology, 2013, Oct-15, Volume: 718, Issue:1-3

    Topics: Analgesics; Animals; Capsaicin; Formaldehyde; Glyburide; Male; Naloxone; Naltrexone; NG-Nitroarginine Methyl Ester; Nociception; Quinoxalines; Rats; Rats, Wistar; Serotonin; Xanthones

2013
Analgesia induced by 2- or 100-Hz electroacupuncture in the rat tail-flick test depends on the anterior pretectal nucleus.
    Life sciences, 2013, Nov-06, Volume: 93, Issue:20

    Topics: Analgesia; Animals; Atropine; Bicuculline; Electroacupuncture; GABA-A Receptor Antagonists; Male; Mesencephalon; Methiothepin; Methysergide; Muscarinic Antagonists; Naloxone; Naltrexone; Narcotic Antagonists; Pain Management; Rats; Rats, Wistar; Serotonin Antagonists; Somatostatin

2013
Novel fentanyl-based dual μ/δ-opioid agonists for the treatment of acute and chronic pain.
    Life sciences, 2013, Dec-18, Volume: 93, Issue:25-26

    Topics: Acute Pain; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chronic Pain; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Enkephalins; Fentanyl; Male; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu

2013
Involvement of spinal release of α-neo-endorphin on the antinociceptive effect of TAPA.
    Peptides, 2013, Volume: 50

    Topics: Analgesia; Analgesics, Opioid; Animals; Endorphins; Gene Expression; Immune Sera; Injections, Spinal; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Naloxone; Naltrexone; Narcotic Antagonists; Nociception; Oligopeptides; Protein Precursors; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord; Tail

2013
Antinociceptive activity of a synthetic oxopyrrolidine-based compound, ASH21374, and determination of its possible mechanisms.
    Canadian journal of physiology and pharmacology, 2013, Volume: 91, Issue:12

    Topics: Analgesics; Analgesics, Opioid; Animals; Aspirin; Capsaicin; Cyclic GMP; Glutamic Acid; Male; Mice; Mice, Inbred BALB C; Morphine; Motor Activity; Naloxone; Naltrexone; Nitric Oxide; Pyrrolidines; Rats, Sprague-Dawley; Receptors, Opioid

2013
[Analgesic properties of morpholinoethylimidazobenzimidazole derivative RU-1205].
    Eksperimental'naia i klinicheskaia farmakologiia, 2013, Volume: 76, Issue:9

    Topics: Analgesics; Animals; Animals, Outbred Strains; Benzimidazoles; Butorphanol; Male; Mice; Morpholines; Naloxone; Naltrexone; Narcotic Antagonists; Nociception; Pain; Pain Measurement; Rats; Receptors, Opioid, kappa

2013
Central antinociception induced by ketamine is mediated by endogenous opioids and μ- and δ-opioid receptors.
    Brain research, 2014, May-08, Volume: 1562

    Topics: Aminopeptidases; Analgesics; Animals; Brain; Cinnamates; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hot Temperature; Ketamine; Leucine; Male; Mice; Morphine Derivatives; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptive Pain; Opioid Peptides; Pain Perception; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu

2014
Desensitization of functional µ-opioid receptors increases agonist off-rate.
    Molecular pharmacology, 2014, Volume: 86, Issue:1

    Topics: Analgesics, Opioid; Animals; Brain; Enkephalins; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Kinetics; Ligands; Naloxone; Naltrexone; Photolysis; Potassium; Rats; Receptors, Opioid, mu

2014
Opioid receptors in the prelimbic cortex modulate restraint stress-induced cardiovascular responses in the rat.
    Neuropharmacology, 2014, Volume: 85

    Topics: Animals; Arterial Pressure; Body Temperature; Cerebral Cortex; Dose-Response Relationship, Drug; Heart Rate; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats, Wistar; Receptors, Opioid; Restraint, Physical; Stress, Psychological; Tachycardia

2014
Opioid modulation of prolactin secretion induced by stress during late pregnancy. Role of ovarian steroids.
    Pharmacological reports : PR, 2014, Volume: 66, Issue:3

    Topics: Analgesics, Opioid; Animals; Estradiol; Female; Mifepristone; Naloxone; Naltrexone; Narcotic Antagonists; Ovary; Pregnancy; Progesterone; Prolactin; Rats; Rats, Wistar; Steroids; Tamoxifen

2014
The opioid receptor pharmacology of GSK1521498 compared to other ligands with differential effects on compulsive reward-related behaviours.
    Psychopharmacology, 2015, Volume: 232, Issue:1

    Topics: Analgesics, Opioid; Animals; CHO Cells; Compulsive Behavior; Cricetinae; Cricetulus; Guanosine 5'-O-(3-Thiotriphosphate); HEK293 Cells; Humans; Indans; Ligands; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Protein Binding; Receptors, Opioid, mu; Reward; Treatment Outcome; Triazoles

2015
Involvement of μ- and δ-opioid receptor function in the rewarding effect of (±)-pentazocine.
    Addiction biology, 2015, Volume: 20, Issue:4

    Topics: Analgesics, Opioid; Analysis of Variance; Animals; Conditioning, Psychological; Dose-Response Relationship, Drug; Isomerism; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Pain; Pentazocine; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Reward

2015
The effectiveness of opioid substitution treatments for patients with opioid dependence: a systematic review and multiple treatment comparison protocol.
    Systematic reviews, 2014, Sep-19, Volume: 3

    Topics: Buprenorphine; Buprenorphine, Naloxone Drug Combination; Heroin; Humans; Methadone; Naloxone; Naltrexone; Narcotics; Opiate Substitution Treatment; Opioid-Related Disorders; Research Design; Systematic Reviews as Topic

2014
Interaction of the adenosine A1 receptor agonist N6-cyclopentyladenosine and κ-opioid receptors in rat spinal cord nociceptive reflexes.
    Behavioural pharmacology, 2014, Volume: 25, Issue:8

    Topics: Adenosine; Animals; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Fentanyl; Inflammation; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Rats; Rats, Wistar; Receptors, Opioid, kappa; Reflex; Spinal Cord

2014
The opioid system majorly contributes to preference for fat emulsions but not sucrose solutions in mice.
    Bioscience, biotechnology, and biochemistry, 2015, Volume: 79, Issue:4

    Topics: Administration, Oral; Animals; Behavior, Animal; Choice Behavior; Dietary Fats; Eating; Emulsions; Food Preferences; Male; Mice; Mice, Inbred BALB C; Naloxone; Naltrexone; Narcotic Antagonists; Phospholipids; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Soybean Oil; Sucrose

2015
Prenatal exposure to vanilla or alcohol induces crawling after these odors in the neonate rat: The role of mu and kappa opioid receptor systems.
    Physiology & behavior, 2015, Sep-01, Volume: 148

    Topics: Analysis of Variance; Animals; Animals, Newborn; Drug-Seeking Behavior; Ethanol; Female; Locomotion; Maternal Exposure; Naloxone; Naltrexone; Odorants; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Vanilla

2015
Effects of β-endorphin on functional activity of mouse splenocytes under conditions of in vivo blockade of μ,δ-opioid receptors.
    Bulletin of experimental biology and medicine, 2015, Volume: 158, Issue:3

    Topics: Animals; beta-Endorphin; Concanavalin A; Interferon-gamma; Interleukin-2; Interleukin-4; Male; Mice; Naloxone; Naltrexone; Receptors, Opioid, delta; Spleen

2015
Types of skin afferent fibers and spinal opioid receptors that contribute to touch-induced inhibition of heart rate changes evoked by noxious cutaneous heat stimulation.
    Molecular pain, 2015, Feb-12, Volume: 11

    Topics: Analgesics, Opioid; Animals; Heart Rate; Hot Temperature; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Pain Management; Rats, Wistar; Receptors, Opioid; Reflex; Skin; Spinal Cord; Touch

2015
Development and validation of a bioanalytical method for the simultaneous determination of heroin, its main metabolites, naloxone and naltrexone by LC-MS/MS in human plasma samples: Application to a clinical trial of oral administration of a heroin/naloxo
    Journal of pharmaceutical and biomedical analysis, 2015, Oct-10, Volume: 114

    Topics: Administration, Oral; Calibration; Chromatography, Liquid; Codeine; Formates; Healthy Volunteers; Heroin; Humans; Hydrogen-Ion Concentration; Limit of Detection; Morphine; Naloxone; Naltrexone; Quality Control; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Substance Abuse Detection; Tandem Mass Spectrometry

2015
Morphine Modulates Interleukin-4- or Breast Cancer Cell-induced Pro-metastatic Activation of Macrophages.
    Scientific reports, 2015, Jun-16, Volume: 5

    Topics: Animals; Arginase; Bone Marrow Cells; Cell Differentiation; Cell Line; Cell Line, Tumor; Cell Movement; Coculture Techniques; Female; Gene Expression Regulation, Neoplastic; Humans; Interleukin-4; Macrophage Activation; Macrophages; Mammary Glands, Animal; Matrix Metalloproteinase 9; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Morphine; Naloxone; Naltrexone; Quaternary Ammonium Compounds; Receptors, Cell Surface; Receptors, Immunologic; Signal Transduction

2015
Pharmacotherapy: Quest for the quitting pill.
    Nature, 2015, Jun-25, Volume: 522, Issue:7557

    Topics: Animals; Behavior, Addictive; Buprenorphine; Buprenorphine, Naloxone Drug Combination; Clinical Trials as Topic; Cocaine-Related Disorders; Counseling; Dopamine; Drug Discovery; Drug Industry; Humans; Ibogaine; Lobeline; Molecular Targeted Therapy; Naloxone; Naltrexone; Oligopeptides; Opioid-Related Disorders; Pleasure; Rats; Receptors, Nicotinic; Reward; Substance-Related Disorders; Tobacco Use Disorder; Vaccines; Vesicular Monoamine Transport Proteins

2015
Species-specific lipophilicity of morphine antagonists.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2015, Oct-12, Volume: 78

    Topics: 1-Octanol; Hydrogen-Ion Concentration; Naloxone; Naltrexone; Narcotic Antagonists; Oxymorphone; Potentiometry; Water

2015
Role of µ, κ, and δ opioid receptors in tibial inhibition of bladder overactivity in cats.
    The Journal of pharmacology and experimental therapeutics, 2015, Volume: 355, Issue:2

    Topics: Acetic Acid; Animals; Cats; Female; Male; Morphinans; Naloxone; Naltrexone; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tibial Nerve; Transcutaneous Electric Nerve Stimulation; Urinary Bladder, Overactive

2015
Brain opioid and nociceptin receptors are involved in regulation of bombesin-induced activation of central sympatho-adrenomedullary outflow in the rat.
    Molecular and cellular biochemistry, 2016, Volume: 411, Issue:1-2

    Topics: Adrenal Medulla; Animals; Bombesin; Brain; Catecholamines; Morphinans; Naloxone; Naltrexone; Nociceptin Receptor; Rats; Receptors, Opioid; Sympathetic Nervous System

2016
Opioid-Induced Constipation Part 2: Newer Therapies #295.
    Journal of palliative medicine, 2015, Volume: 18, Issue:10

    Topics: Analgesics, Opioid; Constipation; Humans; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Polyethylene Glycols; Quaternary Ammonium Compounds

2015
Pharmacological characterization of the opioid inactive isomers (+)-naltrexone and (+)-naloxone as antagonists of toll-like receptor 4.
    British journal of pharmacology, 2016, Volume: 173, Issue:5

    Topics: Animals; Cell Line; Cells, Cultured; Interferon-beta; Interleukin-1beta; Lipopolysaccharides; Macrophages, Peritoneal; Male; Mice; Microglia; Naloxone; Naltrexone; Narcotic Antagonists; Nitric Oxide; Phagocytosis; Rats, Sprague-Dawley; Reactive Oxygen Species; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha

2016
Opioid antagonists block acetaldehyde-induced increments in dopamine neurons activity.
    Drug and alcohol dependence, 2016, Jan-01, Volume: 158

    Topics: Acetaldehyde; Alcoholism; Animals; Dopamine; Dopaminergic Neurons; Dose-Response Relationship, Drug; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Rats; Rats, Wistar; Ventral Tegmental Area

2016
Differences in the morphine-induced inhibition of small and large intestinal transit: Involvement of central and peripheral μ-opioid receptors in mice.
    European journal of pharmacology, 2016, Jan-15, Volume: 771

    Topics: Analgesics, Opioid; Animals; Central Nervous System; Dose-Response Relationship, Drug; Gastrointestinal Transit; Injections, Intraventricular; Intestine, Large; Intestine, Small; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Peripheral Nervous System; Receptors, Opioid, mu

2016
Coactivation of μ- and κ-Opioid Receptors May Mediate the Protective Effect of Testosterone on the Development of Temporomandibular Joint Nociception in Male Rats.
    Journal of oral & facial pain and headache, 2016,Winter, Volume: 30, Issue:1

    Topics: Animals; Brain Stem; Facial Pain; Formaldehyde; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nociception; Nociceptive Pain; Orchiectomy; Rats; Rats, Wistar; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin; Temporomandibular Joint; Temporomandibular Joint Disorders; Testosterone; Trigeminal Caudal Nucleus

2016
Lack of Specific Involvement of (+)-Naloxone and (+)-Naltrexone on the Reinforcing and Neurochemical Effects of Cocaine and Opioids.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2016, Volume: 41, Issue:11

    Topics: Analgesics, Opioid; Anesthetics; Animals; Brain; Cocaine; Conditioning, Operant; Discrimination, Psychological; Dopamine; Extinction, Psychological; Male; Microdialysis; Naloxone; Naltrexone; Narcotic Antagonists; Piperidines; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Remifentanil; Self Administration; Time Factors

2016
Opioid system mediated anti-nociceptive effect of agomelatine in mice.
    Life sciences, 2016, Oct-15, Volume: 163

    Topics: Acetamides; Analgesics; Animals; Dose-Response Relationship, Drug; Injections, Intraventricular; Male; Mice; Motor Activity; Naloxone; Naltrexone; Pain; Pain Measurement; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Rotarod Performance Test

2016
Methyl-orvinol-Dual activity opioid receptor ligand inhibits gastrointestinal transit and alleviates abdominal pain in the mouse models mimicking diarrhea-predominant irritable bowel syndrome.
    Pharmacological reports : PR, 2017, Volume: 69, Issue:2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Abdominal Pain; Analgesics; Analgesics, Opioid; Animals; Colon; Diarrhea; Disease Models, Animal; Gastrointestinal Motility; Gastrointestinal Transit; Irritable Bowel Syndrome; Male; Mice; Mice, Inbred BALB C; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Receptors, Opioid; Thebaine

2017
The differential effects of low and high doses of apelin through opioid receptors on the blood pressure of rats with renovascular hypertension.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2017, Volume: 40, Issue:8

    Topics: Animals; Antihypertensive Agents; Apelin; Benzophenanthridines; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hemodynamics; Hypertension, Renovascular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Protein Kinase C; Rats; Rats, Wistar; Receptors, Opioid

2017
Nalmefene Prevents Alcohol-Induced Neuroinflammation and Alcohol Drinking Preference in Adolescent Female Mice: Role of TLR4.
    Alcoholism, clinical and experimental research, 2017, Volume: 41, Issue:7

    Topics: Alcohol Drinking; Alcohol-Related Disorders; Animals; Astrocytes; Cell Death; Chemokines; Drug Evaluation, Preclinical; Ethanol; Female; Membrane Microdomains; Mice, Inbred C57BL; Mice, Knockout; Myelin Sheath; Naloxone; Naltrexone; Narcotic Antagonists; Primary Cell Culture; Toll-Like Receptor 4

2017
Effects of ICI204,448, naloxone methiodide and levocetirizine on the scratching behavior induced by a κ-opioid antagonist, nor-BNI, in ICR mice.
    Immunopharmacology and immunotoxicology, 2017, Volume: 39, Issue:5

    Topics: Animals; Behavior, Animal; Cetirizine; Male; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Narcotic Antagonists; Pyrrolidines; Quaternary Ammonium Compounds

2017
Opioid system contribution to the antidepressant-like action of m-trifluoromethyl-diphenyl diselenide in mice: A compound devoid of tolerance and withdrawal syndrome.
    Journal of psychopharmacology (Oxford, England), 2017, Volume: 31, Issue:9

    Topics: Analgesics, Opioid; Animals; Antidepressive Agents; Behavior, Animal; Depression; Depressive Disorder; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Organosilicon Compounds; Receptors, Opioid, kappa; Substance Withdrawal Syndrome; Swimming

2017
Opioid receptors mediate inotropic and depressor effects of apelin in rats with 2K1C-induced chronic renovascular hypertension.
    Clinical and experimental pharmacology & physiology, 2018, Volume: 45, Issue:2

    Topics: Animals; Apelin; Blood Pressure; Gene Expression Regulation; Hypertension; Intercellular Signaling Peptides and Proteins; Kidney Diseases; Male; Myocardial Contraction; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid

2018
On-chip pulsed electromembrane extraction as a new concept for analysis of biological fluids in a small device.
    Journal of chromatography. A, 2017, Dec-08, Volume: 1527

    Topics: Blood Chemical Analysis; Codeine; Electrochemistry; Electrodes; Humans; Limit of Detection; Liquid-Liquid Extraction; Membranes, Artificial; Naloxone; Naltrexone; Solvents; Urinalysis

2017
Assessing and improving organizational readiness to implement substance use disorder treatment in primary care: findings from the SUMMIT study.
    BMC family practice, 2017, 12-21, Volume: 18, Issue:1

    Topics: Adult; Alcohol-Related Disorders; Attitude of Health Personnel; Buprenorphine; Cognitive Behavioral Therapy; Delayed-Action Preparations; Delivery of Health Care; Feasibility Studies; Female; Financing, Government; Humans; Los Angeles; Male; Middle Aged; Motivational Interviewing; Naloxone; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Primary Health Care; United States

2017
The effects of recurrent hypoglycaemia and opioid antagonists on the adrenal catecholamine synthetic capacity in a rat model of HAAF.
    Autonomic neuroscience : basic & clinical, 2018, Volume: 210

    Topics: Animals; Blood Glucose; Disease Models, Animal; Epinephrine; Hypoglycemia; Hypoglycemic Agents; Insulin; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pure Autonomic Failure; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley; Serine; Tyrosine 3-Monooxygenase

2018
The Chemokine CCL4 (MIP-1β) Evokes Antinociceptive Effects in Mice: a Role for CD4
    Molecular neurobiology, 2019, Volume: 56, Issue:3

    Topics: Analgesics; Animals; CD4-Positive T-Lymphocytes; Chemokine CCL4; Enkephalin, Methionine; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Nociception; Pain; Pain Measurement

2019
Abuse liability and therapeutic potential of the Mitragyna speciosa (kratom) alkaloids mitragynine and 7-hydroxymitragynine.
    Addiction biology, 2019, Volume: 24, Issue:5

    Topics: Analgesics, Opioid; Animals; Behavior, Animal; Mitragyna; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Secologanin Tryptamine Alkaloids; Self Administration

2019
In Vitro Pharmacological Characterization of Buprenorphine, Samidorphan, and Combinations Being Developed as an Adjunctive Treatment of Major Depressive Disorder.
    The Journal of pharmacology and experimental therapeutics, 2018, Volume: 367, Issue:2

    Topics: Animals; beta-Arrestins; Buprenorphine; Cell Line; CHO Cells; Cricetulus; Depressive Disorder, Major; Drug Combinations; GTP-Binding Proteins; HEK293 Cells; Humans; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Receptors, Opioid, mu

2018
Tackling addiction in primary care.
    Minnesota medicine, 2017, Volume: 100, Issue:3

    Topics: Alcoholism; Buprenorphine; Drug Combinations; Humans; Illicit Drugs; Interdisciplinary Communication; Intersectoral Collaboration; Mass Screening; Minnesota; Naloxone; Naltrexone; Opioid-Related Disorders; Prescription Drugs; Primary Health Care; Referral and Consultation; Substance-Related Disorders

2017
The antihyperalgesic effect of docosahexaenoic acid in streptozotocin-induced neuropathic pain in the rat involves the opioidergic system.
    European journal of pharmacology, 2019, Feb-15, Volume: 845

    Topics: Analgesics; Analgesics, Opioid; Animals; Diabetic Neuropathies; Docosahexaenoic Acids; Dose-Response Relationship, Drug; Gabapentin; Naloxone; Naltrexone; Rats; Rats, Wistar; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, sigma; Streptozocin

2019
Possible involvement of the μ opioid receptor in the antinociception induced by sinomenine on formalin-induced nociceptive behavior in mice.
    Neuroscience letters, 2019, 04-23, Volume: 699

    Topics: Administration, Oral; Analgesics; Animals; Dose-Response Relationship, Drug; Formaldehyde; Male; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morphinans; Naloxone; Naltrexone; Nociception; Receptors, Opioid, mu; Spinal Cord

2019
A further assessment of a role for Toll-like receptor 4 in the reinforcing and reinstating effects of opioids.
    Behavioural pharmacology, 2020, Volume: 31, Issue:2&3

    Topics: Analgesics, Opioid; Animals; Conditioning, Operant; Heroin; Male; Naloxone; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Self Administration; Toll-Like Receptor 4

2020
Suppression of Human Natural Killer Cells by Different Classes of Opioids.
    Anesthesia and analgesia, 2019, Volume: 128, Issue:5

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Anesthesia; Buprenorphine; Enkephalin, D-Penicillamine (2,5)-; Fentanyl; Fluoresceins; Humans; Immunosuppression Therapy; K562 Cells; Killer Cells, Natural; Loperamide; Methadone; Morphinans; Morphine; Naloxone; Naltrexone; Succinimides; Toll-Like Receptor 4; Tramadol

2019
The Blockade of µ1- and κ-Opioid Receptors in the Inferior Colliculus Decreases the Expression of Panic Attack-Like Behaviours Induced by Chemical Stimulation of the Dorsal Midbrain.
    Neuropsychobiology, 2019, Volume: 78, Issue:4

    Topics: Animals; Behavior, Animal; Bicuculline; Exploratory Behavior; GABA-A Receptor Antagonists; Inferior Colliculi; Male; Mesencephalon; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Panic; Rats; Rats, Wistar; Receptors, Opioid, kappa; Receptors, Opioid, mu

2019
Changes in murine respiratory dynamics induced by aerosolized carfentanil inhalation: Efficacy of naloxone and naltrexone.
    Toxicology letters, 2019, Volume: 316

    Topics: Administration, Inhalation; Aerosols; Analgesics, Opioid; Animals; Computer Simulation; Dose-Response Relationship, Drug; Fentanyl; Humans; Lung; Male; Mice; Models, Biological; Naloxone; Naltrexone; Narcotic Antagonists; Plethysmography, Whole Body; Respiration; Respiratory Insufficiency; Risk Assessment

2019
Hide and Seek: Overcoming the Masking Effect of Opioid Antagonists in Activity-Based Screening Tests.
    Clinical chemistry, 2019, Volume: 65, Issue:12

    Topics: Analgesics, Opioid; Animals; Humans; Naloxone; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Substance Abuse Detection

2019
Peripheral antinociception induced by ketamine is mediated by the endogenous opioid system.
    European journal of pharmacology, 2019, Dec-15, Volume: 865

    Topics: Analgesics; Animals; Cinnamates; Dinoprostone; Ketamine; Male; Mice; Morphine Derivatives; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Receptors, Opioid, delta; Receptors, Opioid, mu

2019
Pharmacological evaluation underlying the antinociceptive activity of two new hybrids NSAIDs tetrahydropyran derivatives.
    Fundamental & clinical pharmacology, 2020, Volume: 34, Issue:3

    Topics: Adenosine Triphosphate; Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclic GMP; Cyclooxygenase Inhibitors; Dizocilpine Maleate; Formaldehyde; Glyburide; Humans; Male; Mice; Naloxone; Naltrexone; NG-Nitroarginine Methyl Ester; Pain; Pain Measurement; Potassium Channels; Prostaglandin-Endoperoxide Synthases; Receptors, N-Methyl-D-Aspartate; Signal Transduction

2020
Dipyrone is locally hydrolyzed to 4-methylaminoantipyrine and its antihyperalgesic effect depends on CB
    European journal of pharmacology, 2020, May-05, Volume: 874

    Topics: Analgesics; Animals; Cannabinoid Receptor Antagonists; Carrageenan; Dipyrone; Hydrolysis; Hyperalgesia; Indoles; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats, Wistar; Receptor, Cannabinoid, CB2; Receptors, Opioid, kappa; Somatostatin

2020
The Role of Cardiac Opioid Receptors in the Cardioprotective Effect of Continuous Normobaric Hypoxia.
    Bulletin of experimental biology and medicine, 2020, Volume: 168, Issue:6

    Topics: Adaptation, Physiological; Animals; Benzylidene Compounds; Creatine Kinase; Hypoxia; Male; Myocardial Reperfusion Injury; Myocardium; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Organ Culture Techniques; Peptides; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tetrahydroisoquinolines

2020
Single-molecule analysis reveals agonist-specific dimer formation of µ-opioid receptors.
    Nature chemical biology, 2020, Volume: 16, Issue:9

    Topics: Animals; beta-Arrestins; CHO Cells; Cricetulus; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Fluorescence Resonance Energy Transfer; Morphine; Mutation; Naloxone; Naltrexone; Narcotic Antagonists; Phosphorylation; Protein Multimerization; Receptors, Opioid, mu; Single Molecule Imaging

2020
Naloxone-Induced Acute Opioid Withdrawal in a Stabilized Extended-Release Naltrexone-Treated Patient.
    The primary care companion for CNS disorders, 2020, Sep-17, Volume: 22, Issue:5

    Topics: Analgesics, Opioid; Humans; Naloxone; Naltrexone; Narcotic Antagonists; Substance Withdrawal Syndrome

2020
A low pKa ligand inhibits cancer-associated pain in mice by activating peripheral mu-opioid receptors.
    Scientific reports, 2020, 10-29, Volume: 10, Issue:1

    Topics: Analgesics, Opioid; Animals; Bone Neoplasms; Cancer Pain; Cell Line, Tumor; Fentanyl; Hydrogen-Ion Concentration; Hyperalgesia; Ligands; Male; Melanoma, Experimental; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Piperidines; Receptors, Opioid, mu

2020
Mechanisms of QT prolongation by buprenorphine cannot be explained by direct hERG channel block.
    PloS one, 2020, Volume: 15, Issue:11

    Topics: Buprenorphine; Electrocardiography; Ether-A-Go-Go Potassium Channels; HEK293 Cells; Humans; Induced Pluripotent Stem Cells; Ion Channel Gating; Methadone; Myocytes, Cardiac; Naloxone; Naltrexone; Potassium Channel Blockers; Receptors, Opioid; Time Factors

2020
A study of the effectiveness of naltrexone in preventing recurrence of methadone poisoning in opioid-naive children.
    Drug and alcohol dependence, 2021, 02-01, Volume: 219

    Topics: Adolescent; Aftercare; Analgesics, Opioid; Child; Child, Preschool; Female; Hospitalization; Humans; Infant; Intensive Care Units; Iran; Male; Methadone; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Neoplasms; Patient Discharge; Poisoning; Recurrence; Retrospective Studies

2021
Systematic Structure-Based Virtual Screening Approach to Antibody Selection and Design of a Humanized Antibody against Multiple Addictive Opioids without Affecting Treatment Agents Naloxone and Naltrexone.
    ACS chemical neuroscience, 2021, 01-06, Volume: 12, Issue:1

    Topics: Analgesics, Opioid; Heroin; Morphine; Naloxone; Naltrexone

2021
Comparing actual and forecasted numbers of unique patients dispensed select medications for opioid use disorder, opioid overdose reversal, and mental health, during the COVID-19 pandemic, United States, January 2019 to May 2020.
    Drug and alcohol dependence, 2021, 02-01, Volume: 219

    Topics: Analgesics, Opioid; Angiotensin Receptor Antagonists; Antidepressive Agents; Benzodiazepines; Buprenorphine; COVID-19; Drug Utilization; Forecasting; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Naloxone; Naltrexone; Opiate Overdose; Opioid-Related Disorders; Pandemics; SARS-CoV-2; United States

2021
Naloxone-induced analgesia mediated by central kappa opioid system in chronic inflammatory pain.
    Brain research, 2021, 07-01, Volume: 1762

    Topics: Analgesia; Analgesics, Opioid; Animals; Chronic Pain; Inflammation Mediators; Male; Mice; Mice, Inbred C57BL; Microinjections; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, kappa

2021
Endogenous opioid and cannabinoid systems modulate the muscle pain: A pharmacological study into the peripheral site.
    European journal of pharmacology, 2021, Jun-15, Volume: 901

    Topics: Animals; Arachidonic Acids; Carrageenan; Cinnamates; Endocannabinoids; Hyperalgesia; Male; Monoacylglycerol Lipases; Morphine Derivatives; Myalgia; Naloxone; Naltrexone; Pain Measurement; Polyunsaturated Alkamides; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu

2021
Antinociceptive Efficacy of the µ-Opioid/Nociceptin Peptide-Based Hybrid KGNOP1 in Inflammatory Pain without Rewarding Effects in Mice: An Experimental Assessment and Molecular Docking.
    Molecules (Basel, Switzerland), 2021, 05-28, Volume: 26, Issue:11

    Topics: Acute Pain; Analgesics; Animals; Behavior, Animal; CHO Cells; Cricetinae; Cricetulus; Cycloheptanes; Humans; Hyperalgesia; In Vitro Techniques; Inflammation; Male; Mice; Models, Molecular; Molecular Docking Simulation; Morphine; Movement; Naloxone; Naltrexone; Nociceptin; Oligopeptides; Opioid Peptides; Pain Management; Piperidines; Receptors, Opioid, mu

2021
Increasingly powerful opioid antagonists are not necessary.
    The International journal on drug policy, 2022, Volume: 99

    Topics: Humans; Naloxone; Naltrexone; Narcotic Antagonists

2022
Trends in pharmacy-based dispensing of buprenorphine, extended-release naltrexone, and naloxone during the COVID-19 pandemic by age and sex - United States, March 2019 - December 2020.
    Drug and alcohol dependence, 2022, 03-01, Volume: 232

    Topics: Adult; Analgesics, Opioid; Buprenorphine; COVID-19; Female; Humans; Male; Middle Aged; Naloxone; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Pandemics; Pharmacy; SARS-CoV-2; United States; Young Adult

2022
Opioid Antagonist Nanodrugs Successfully Attenuate the Severity of Ischemic Stroke.
    Molecular pharmaceutics, 2022, 07-04, Volume: 19, Issue:7

    Topics: Analgesics, Opioid; Animals; Ischemic Stroke; Mice; Morphine; Naloxone; Naltrexone; Nanoparticles; Narcotic Antagonists; Opioid-Related Disorders; Oxycodone; Stroke; Tight Junction Proteins

2022
Selective and antagonist-dependent µ-opioid receptor activation by the combination of 2-{[2-(6-chloro-3,4-dihydro-1(2H)-quinolinyl)-2-oxoethyl]sulfanyl}-5-phenyl-4,6-(1H,5H)-pyrimidinedione and naloxone/naltrexone.
    Bioorganic chemistry, 2022, Volume: 128

    Topics: Analgesics, Opioid; Imidazoles; Naloxone; Naltrexone; Receptors, Opioid; Sulfonamides; Thiophenes

2022
Opioid antagonism in humans: a primer on optimal dose and timing for central mu-opioid receptor blockade.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2023, Volume: 48, Issue:2

    Topics: Analgesics, Opioid; Animals; Humans; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, mu

2023
Naloxone Versus Methylnaltrexone for Opioid-Induced Constipation in Critically Ill Patients.
    The Annals of pharmacotherapy, 2023, Volume: 57, Issue:7

    Topics: Adult; Analgesics, Opioid; Constipation; Critical Illness; Humans; Naloxone; Naltrexone; Narcotic Antagonists; Opioid-Induced Constipation; Pain; Prospective Studies; Quaternary Ammonium Compounds; Retrospective Studies

2023
Promising biomedical subcutaneous delivery system in opioid disaccustom process: In vitro/in vivo evaluation of naloxone microparticles on antagonist effect of morphine.
    International journal of pharmaceutics, 2023, Mar-25, Volume: 635

    Topics: Analgesics, Opioid; Animals; Guinea Pigs; Humans; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Neuroblastoma

2023
In brief: Over-the-counter Narcan nasal spray.
    The Medical letter on drugs and therapeutics, 2023, 05-01, Volume: 65, Issue:1675

    Topics: Analgesics, Opioid; Buprenorphine; Humans; Naloxone; Naltrexone; Narcotic Antagonists; Nasal Sprays; Opiate Substitution Treatment; Opioid-Related Disorders

2023
Racial Inequality in Receipt of Medications for Opioid Use Disorder.
    The New England journal of medicine, 2023, May-11, Volume: 388, Issue:19

    Topics: Aged; Analgesics, Opioid; Benzodiazepines; Black or African American; Buprenorphine; Healthcare Disparities; Hispanic or Latino; Humans; Medicare; Naloxone; Naltrexone; Narcotic Antagonists; Opiate Overdose; Opioid-Related Disorders; United States; White

2023
Nalmefene nasal spray (Opvee) for reversal of opioid overdose.
    The Medical letter on drugs and therapeutics, 2023, 10-16, Volume: 65, Issue:1687

    Topics: Analgesics, Opioid; Drug Overdose; Humans; Naloxone; Naltrexone; Narcotic Antagonists; Nasal Sprays; Opiate Overdose

2023