naltrexone has been researched along with morphine in 1270 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 375 (29.53) | 18.7374 |
| 1990's | 401 (31.57) | 18.2507 |
| 2000's | 292 (22.99) | 29.6817 |
| 2010's | 178 (14.02) | 24.3611 |
| 2020's | 24 (1.89) | 2.80 |
| Authors | Studies |
|---|---|
| Berkowitz, DS; Loew, GH | 1 |
| Cheney, BV | 1 |
| Fries, DS; Larson, DL; Portoghese, PS; Sayre, LM; Takemori, AE | 1 |
| Alreja, BD; Larson, DL; Portoghese, PS | 1 |
| Portoghese, PS; Takemori, AE | 3 |
| Archer, S; Gillan, MG; Kosterlitz, HW; Osei-Gyimah, P | 1 |
| Bousquet, AR; Howes, JF; Kotick, MP; Leland, DL; Polazzi, JO | 1 |
| Bell, GI; Chen, Y; Kong, H; Raynor, K; Reisine, T; Yasuda, K; Yu, L | 1 |
| Adapa, ID; Auh, JS; Berzetei-Gurske, IP; Brandt, SR; Craymer, K; Farrington, L; Haggart, D; Kennedy, JM; O'Brien, A; Polgar, WE; Rodriguez, L; Schwartz, RW; Toll, L; White, A | 1 |
| Strassburg, CP; Tukey, RH | 1 |
| Carrupt, PA; Crivori, P; Cruciani, G; Testa, B | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Bidlack, JM; Cohen, DJ; Dehnhardt, CM; Duan, W; Lou, R; Wentland, MP | 1 |
| Ananthan, S; Bartlett, JL; Bilsky, EJ; Davis, P; Dersch, CM; Khare, NK; Porreca, F; Rothman, RB; Saini, SK; Seitz, LE | 1 |
| Chang, TK; Ensom, MH; Kiang, TK | 1 |
| Jolivette, LJ; Ward, KW | 1 |
| Broadbear, J; Carrington, S; Husbands, SM; Lewis, JW; Moynihan, HA; Nieland, NP; Traynor, JR; Woods, JH | 1 |
| Hebbel, RP; Lunzer, MM; Portoghese, PS; Yekkirala, A | 1 |
| Andricopulo, AD; Moda, TL; Montanari, CA | 1 |
| Aceto, MD; Cami-Kobeci, G; Husbands, SM; Lewis, JW; Martinez-Bermejo, F; Neal, AP; Rennison, D | 1 |
| Aceto, MD; Coop, A; Harris, LS; May, EL; Metcalf, MD; Traynor, JR; Woods, JH | 1 |
| Al-Khrasani, M; Ballet, S; Benyhe, S; Borics, A; Feytens, D; Fürst, Z; Kövér, KE; Lovas, S; Tömböly, C; Tóth, G; Tourwé, D | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Bidlack, JM; Bu, Y; Cohen, DJ; Lou, R; Lu, Q; VanAlstine, MA; Wentland, MP | 1 |
| Aschenbach, LC; Cassidy, MP; Chen, J; Dewey, WL; Gabra, BH; Li, G; Selley, DE; Stevens, DL; Westkaemper, RB; Zhang, Y | 1 |
| Broadbear, JH; Greedy, BM; Husbands, SM; Jales, AR; Lewis, JW; Moynihan, H; Purington, L; Rennison, D; Traynor, JR; Woods, JH | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Alelyunas, YW; Bui, K; Empfield, JR; McCarthy, D; Pelosi-Kilby, L; Shen, C; Spreen, RC | 1 |
| Burgman, M; Grinnell, S; Haselton, N; Majumdar, S; Ocampo, J; Pasternak, AR; Pasternak, GW | 1 |
| Fujii, H; Hasebe, K; Mochizuki, H; Nagase, H; Nakajima, M; Nemoto, T; Watanabe, A | 1 |
| Fujii, H; Hasebe, K; Izumimoto, N; Mochizuki, H; Momen, S; Nagase, H; Nakajima, R; Nemoto, T; Yamamoto, N | 1 |
| Fujii, H; Hirayama, S; Koyano, K; Mochizuki, H; Nagase, H; Nakajima, M; Nakao, K; Nemoto, T; Wada, N; Watanabe, A | 1 |
| Burgman, M; Grinnell, S; Haselton, N; Le Rouzic, V; Majumdar, S; Nagakura, K; Ocampo, J; Pan, YX; Pasternak, AR; Pasternak, GW; Polikar, L; Subrath, J | 1 |
| Akbarali, HI; Akubathini, SK; Beletskaya, IO; Chen, J; Dewey, WL; Elbegdorj, O; Gerk, PM; Scoggins, KL; Selley, DE; Stevens, DL; Yuan, Y; Zhang, F; Zhang, Y; Zhang, Z | 1 |
| Dewey, WL; Kellogg, GE; Mosier, PD; Scoggins, KL; Selley, DE; Stevens, DL; Yuan, Y; Zaidi, SA; Zhang, Y | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Brockmöller, J; Friesacher, HR; Meyer, MJ; Neumann, VE; Tzvetkov, MV; Zdrazil, B | 1 |
| Geller, I; Hartmann, RJ | 1 |
| Capozza, RC; Schmitt, EE; Sendelbeck, LR | 2 |
| Misra, AL; Pontani, RB | 2 |
| Ahtee, L; Carlsson, A; Garcia-Sevilla, JA; Magnusson, T | 1 |
| Moroni, F | 1 |
| Caruso, TP; Larson, DL; Portoghese, PS; Takemori, AE | 2 |
| Järbe, TU; Rollenhagen, C | 1 |
| Smith, JB | 2 |
| Ary, M; Chesarek, W; Lomax, P; Sorensen, SM | 1 |
| Craviso, GL; Gascon, P; Musacchio, JM; Puig, MM | 1 |
| Biggio, G; Costa, E; Guidotti, A | 1 |
| Costa, E; Dill, RE | 1 |
| Terenius, L | 2 |
| Bohus, B; de Wied, D; Urban, I; van Ree, JM | 1 |
| Blume, AJ | 1 |
| Caruso, TP; Jiang, JB; Larson, DL; Portoghese, PS; Takemori, AE | 2 |
| Cheney, DL; Costa, E; Moroni, F; Peralta, E | 2 |
| Bruno, F; Iuliano, E; Paoletti, R; Racagni, G | 1 |
| Cicero, TJ; Meyer, ER; Schainker, BA | 1 |
| Downs, DA; Harrigan, SE | 2 |
| Berkowitz, BA; Hynes, MD | 1 |
| Croiset, G; de Rotte, GA; Goedemans, HJ; Thody, TJ; van Ree, JM; van Wimersma Greidanus, TB; Verspaget, H | 1 |
| Järbe, TU; Loman, P; Swedberg, MD | 1 |
| Fennessy, MR; Laska, FJ | 1 |
| Bhargava, HN | 3 |
| Harry, GJ; Rosecrans, JA | 1 |
| Gellert, VF; Holtzman, SG | 1 |
| Burks, TF; Stewart, JJ; Weisbrodt, NW | 1 |
| Misra, AL; Pontani, RB; Vadlamani, NL | 1 |
| D'Mello, GD; Pilcher, CW; Stolerman, IP | 1 |
| Blumberg, H; Ikeda, C | 1 |
| Johnson, JH; Maughan, GT; Rosecrans, JA | 1 |
| Bailey, B; Diaz, J; Paul, L | 1 |
| Berti, F; Bruno, F; Omini, C; Racagni, G | 1 |
| Järbe, TU | 1 |
| Appel, JB; Hernandez, LL; Holohean, AM | 1 |
| Howes, JF; Schwope, AD; Wise, DL | 1 |
| Gehrmann, JE; Killam, KF | 1 |
| Colombel, MC; Jacob, J; Tremblay, E | 1 |
| Holtzman, SG; Shannon, HE | 1 |
| Frank, S; Malspeis, L; Notari, RE; Reuning, RH | 1 |
| Brocco, MJ; Killam, KF; Robinson, CA | 1 |
| Cheney, DL; Costa, E; Racagni, G; Zsilla, G | 2 |
| Hanson, RN; Jiang, JB; Portoghese, PS; Takemori, AE | 1 |
| Cheney, DL; Costa, E; Moroni, F | 1 |
| Cash, C; King, LJ; Minnema, KH | 1 |
| Eades, CG; Gilbert, PE; Huppler, RE; Martin, WR; Thompson, JA | 1 |
| Ary, M; Lomax, P | 1 |
| Foldes, FF; Knoll, J; Rich, J; Vizi, ES | 1 |
| Gray, AP; Guardina, WJ | 2 |
| Kalkwarf, DR; Sullivan, MF | 1 |
| Arnold, DL; Granchelli, FE; Nelsen, L; Sheth, SG; Sidman, KR; Steber, WD; Strong, P | 2 |
| Jhamandas, K; Sutak, M | 1 |
| Berkowitz, BA; Finck, AD; Ngai, SH | 1 |
| Geller, I; Hartmann, RJ; Ross, D | 1 |
| McNamee, HB; Meyer, RE; Mirin, SM | 1 |
| Chen, RC; Ho, AK | 1 |
| Fishman, J; Hahn, EF; Norton, BI | 1 |
| Dimaio, J; Nogrady, T | 1 |
| Greenstein, RA; Mintz, J; O'Brien, CP; Woody, GE | 1 |
| Kalkward, DR; Sullivan, MF | 1 |
| Goldstein, A | 1 |
| Chen, RP; Fishman, J; Gray, MI; Hahn, EF; Heilman, RD | 1 |
| Berggren, A; Rubenson, A; Sillén, U | 1 |
| Di Giulio, AM; Donadoni, ML; Finco, C; Germani, E; Gorio, A; Malosio, ML; Mantegazza, P; Tenconi, B | 1 |
| Auerbach, SB; Grauer, SM; Tao, R | 1 |
| Craft, RM; Dykstra, LA | 2 |
| Maneckjee, R; Minna, JD | 1 |
| Robinson, SR; Smotherman, WP | 1 |
| Baraban, JM; Bhat, RV; Cole, AJ; Worley, PF | 1 |
| Portoghese, PS; Sofuoglu, M; Takemori, AE | 1 |
| Billings, B; Candido, J; Duttaroy, A; Inturrisi, CE; Lutfy, K; Sierra, V; Yoburn, BC | 1 |
| Tang, RR; Tseng, LF | 1 |
| Dickenson, AH; Kalso, EA; McQuay, HJ; Sullivan, AF | 1 |
| Burke, TF; Comer, SD; Lewis, JW; Woods, JH | 1 |
| Malmberg, AB; Yaksh, TL | 1 |
| Billings, B; Candido, J; Duttaroy, A; Yoburn, BC | 1 |
| Riley, AL; Smurthwaite, ST | 1 |
| Abood, LG; Hashmi, M; Lerner-Marmarosh, N; Manda, S | 1 |
| Crebolder, J; Maier, S; Parker, LA; Rennie, M | 1 |
| Cabral, JD; Leedham, JA; Monroe, PJ; Robertson, B; Smith, DJ; Taylor, DA | 1 |
| Bertalmio, AJ; Woods, JH | 1 |
| Fujimoto, JM; Holmes, BB | 2 |
| Flores, CM; Hornby, PJ; Hulihan-Giblin, BA; Kellar, KJ; Lumpkin, MD | 1 |
| Song, SH; Takemori, AE | 1 |
| Kastin, AJ; Kersh, D; Wyatt, A; Zadina, JE | 1 |
| Katafuchi, T; Koizumi, K; Nagatomo, I | 1 |
| Doty, P; Dykstra, LA; Johnson, AB; Picker, MJ | 1 |
| Stewart, J; Wise, RA | 1 |
| Fournié-Zaluski, MC; Noble, F; Roques, BP; Turcaud, S | 1 |
| Stamidis, H; Young, GA | 1 |
| Misawa, M; Nagase, H; Narita, M; Suzuki, T; Takahashi, Y | 1 |
| Adler, MW; Bussiere, JL; Eisenstein, TK; Rogers, TJ | 2 |
| Heller, J; Roskos, KV; Tefft, JA | 2 |
| Holtzman, SG; Paronis, CA | 1 |
| Goosen, C; Kornet, M; Van Ree, JM | 2 |
| Misawa, M; Nagase, H; Narita, M; Suzuki, T | 2 |
| Goldberg, SR; Grayson, NA; Jaffe, JH; Johnson, RE; Katz, JL; Rice, KC; Witkin, JM | 1 |
| Abdelhamid, EE; Portoghese, PS; Sultana, M; Takemori, AE | 1 |
| Adamson, WT; Blackford, S; Kuhn, CM; Windh, RT | 1 |
| France, CP; Medzihradsky, F; Rice, KC; Seggel, MR; Winger, G; Woods, JH | 1 |
| Mjanger, E; Yaksh, TL | 1 |
| Chang, SC; Lutfy, K; Sierra, V; Yoburn, BC | 1 |
| Agbas, A; Ahmed, MS; Cemerikic, B; Cheng, J | 1 |
| Kaneto, H; Takahashi, M | 1 |
| Carden, SE; Hofer, MA | 2 |
| Jang, Y; Yoburn, BC | 1 |
| Collins, JG; Kitahata, LM; Nakatani, K; Omote, K | 1 |
| de Costa, BR; Drower, EJ; Hammond, DL; Rafferty, MF; Rice, KC; Stapelfeld, A | 1 |
| Jessop, JJ; Taplits, MS | 1 |
| Millard, WJ; Simpkins, JW; Swager, D | 1 |
| Kaneto, H; Senda, T; Takahashi, M | 1 |
| Kamei, J; Kasuya, Y; Tanihara, H | 2 |
| Cowan, A; Li, SX; Liu-Chen, LY; Wheeler-Aceto, H | 1 |
| Furuya, Y; Kaneko, T; Nakazawa, T; Yamatsu, K | 1 |
| Sharpe, LG | 1 |
| Song, ZH; Takemori, AE | 2 |
| Adams, JU; Holtzman, SG | 1 |
| Crisp, T; Perni, VC; Spanos, LJ; Stafinsky, JL; Uram, M; Weaver, MF | 1 |
| Banks, WA; Kastin, AJ; Pearson, MA | 1 |
| Chesley, S; Greenblatt, DJ; Lopez, F; Miller, LG; Schatzki, A; Shader, RI; Thompson, ML | 1 |
| Duman, RS; Hayward, MD; Nestler, EJ | 1 |
| Newsom, GC; Spain, JW | 1 |
| Ariznavarreta, C; González-Quijano, MI; López-Calderón, A; Martín, AI; Treguerres, JA | 1 |
| Arora, PK; McIntyre, T; Sei, Y; Skolnick, P; Yoshimoto, K | 1 |
| Fuller, RW; Ornstein, PL; Perry, KW; Rasmussen, K; Stockton, ME; Swinford, RM | 1 |
| Cone, EJ; Vaupel, DB | 1 |
| Lutfy, K; Yoburn, BC | 1 |
| Giordano, J; Hughes, RA; Sufka, KJ | 1 |
| Pasternak, GW; Paul, D; Pick, CG | 1 |
| Jacoby, HI; Martinez, RP; Raffa, RB; Schupsky, JJ | 1 |
| Armario, A; Garvey, JS; Giralt, M; Hidalgo, J | 1 |
| Kehoe, P; Shoemaker, W | 1 |
| Allen, AR; Galizio, M | 1 |
| Larson, DL; Portoghese, PS; Takemori, AE; Yim, CB | 1 |
| Kaneto, H; Takahashi, M; Watanabe, J | 1 |
| Allen, JT; Brostrom, PA; DeHaven-Hudkins, DL; Ferkany, JW; Kaplita, PV; Lesko, LJ; Mavunkel, BJ; Rzeszotarski, WJ; Steranka, LR | 1 |
| Abbott, FV | 1 |
| Lee, C; Rodgers, RJ | 1 |
| Arts, KS; Fujimoto, JM | 1 |
| Doty, MD; Mattox, SR; Young, AM | 1 |
| Fudala, PJ; Heishman, SJ; Henningfield, JE; Johnson, RE | 1 |
| Calcagnetti, DJ; Holtzman, SG | 1 |
| Arora, PK; Fride, E; McIntyre, T; Sei, Y; Skolnick, P; Yoshimoto, K | 1 |
| Bilsky, EJ; Marglin, SH; Reid, LD | 1 |
| Abboud, TK; Afrasiabi, A; Davidson, J; Khoo, N; Reyes, A; Steffens, Z; Zhu, J | 1 |
| Dionne, RA; Flores, CM; Hargreaves, KM; Mueller, GP | 1 |
| Cone, EJ; Johnson, RE; Su, TP; Vaupel, DB | 1 |
| Bayer, BM; Hernandez, M; Irvin, L | 1 |
| Mucha, RF | 2 |
| de Costa, BR; France, CP; Jacobson, AE; Rice, KC; Woods, JH | 1 |
| Heyman, JS; Koslo, RJ; Porreca, F; Qi, JA; Sheldon, RJ | 1 |
| Bayer, BM; Daussin, S; Hernandez, M; Irvin, L | 1 |
| Barr, GA; Capuano, CA; Leibowitz, SF | 1 |
| Ceresoli, G; Groppetti, A; Mandelli, V; Parenti, M | 1 |
| Suh, HH; Tseng, LF | 2 |
| LoPresti, D; Porreca, F; Ward, SJ | 1 |
| Davenport, KE; Houdi, AA; Van Loon, GR | 1 |
| Fukagawa, Y; Misawa, M; Nagase, H; Suzuki, T | 1 |
| Kaneto, H; Senda, T; Takahashi, M; Tokuyama, S | 1 |
| Mosberg, HI; Porreca, F; Qi, JA | 1 |
| Hammer, RP; Ricalde, AA | 1 |
| Balfour, HH; Gekker, G; Peterson, PK; Portoghese, PS; Sannerud, K; Sharp, BM | 1 |
| Ben-Zvi, Z; Hurwitz, A; Looney, G; Sullins, M | 1 |
| Adams, JU; Holtzman, SG; Paronis, CA | 1 |
| Ayres, EA; Burks, TF; Davis, P | 1 |
| Lutfy, K; Sierra, V; Yoburn, BC | 2 |
| Abboud, TK; Afrasiabi, A; Chai, M; Lee, K; Mantilla, M; Reyes, A; Steffens, Z; Zhu, J | 1 |
| Garrett, ER; Khan, PJ; Langguth, P | 1 |
| Bryant, HU; Roudebush, RE | 1 |
| Ahtee, L; Attila, LM; Carlson, KR | 1 |
| Aranow, JS; Kelsey, JE; Matthews, RT | 1 |
| Cowan, A; Murray, CW | 1 |
| Costello, A; Dubner, R; Hargreaves, KM; Joris, J | 1 |
| Bhargava, HN; Ramarao, P | 2 |
| Akil, H; Trujillo, KA | 1 |
| Conti, A; Marzanatti, M; Monopoli, A; Ongini, E; Trampus, M | 1 |
| Arrigo-Reina, R | 1 |
| Goldberg, SR; Katz, JL; Schindler, CW; Su, TP; Wu, XZ | 1 |
| Cherubini, E; North, RA; Tokimasa, T | 1 |
| Beilin, B; Gale, RP; Liebeskind, JC; Martin, FC; Shavit, Y | 1 |
| Cheng, SW; North, WG; O'Connor, EF | 1 |
| Holtzman, SG | 7 |
| Gauvin, DV; Young, AM | 1 |
| Costa, E; Mocchetti, I; Ritter, A | 1 |
| Melzack, R; Tasker, RAR; Vaccarino, AL | 1 |
| Bergman, J; Warren, PH | 1 |
| Blass, EM; Kehoe, P | 2 |
| Brady, LS; Bykov, V; Holaday, JW; Jacobson, AE; Long, JB; Rice, KC; Rothman, RB | 1 |
| Bardo, MT; Neisewander, JL; Pierce, RC | 1 |
| Niesink, RJ; Van Ree, JM | 1 |
| Falls, WA; Kelsey, JE | 1 |
| France, CP; Morse, WH | 1 |
| France, CP; Woods, JH | 8 |
| Fiserová, M; Metys, J | 1 |
| Chavkin, C; Opheim, KE; Wimpey, TL | 1 |
| Guitart, X; Nestler, EJ | 1 |
| Ahmed, MS; Quarles, C; Schoof, T; Zhou, DH | 1 |
| Bykov, V; Holaday, JW; Long, JB; Rice, KC; Rothman, RB | 1 |
| Garzón, J; Sánchez-Blázquez, P | 2 |
| Jackson, HC; Kitchen, I | 1 |
| Boja, JW; Crisp, T; Schechter, MD; Stafinsky, JL | 1 |
| Flores, CM; Hulihan-Giblin, BA; Kellar, KJ | 1 |
| Aghajanian, GK; Rasmussen, K | 1 |
| Garzón, J; Sánchez-Blázquez, P; Ulibarri, I | 1 |
| Brase, DA; Dewey, WL; Han, YH; Lux, F | 1 |
| Valentino, RJ; Wehby, RG | 2 |
| Field, EA; Kuhn, CM | 1 |
| Pert, A; Weber, RJ | 1 |
| Attila, LM | 1 |
| Harbison, RD; James, RC; Roberts, SM; Skoulis, NP | 1 |
| Bechara, A; van der Kooy, D | 1 |
| Linseman, MA | 1 |
| Kotlińska, J; Langwiński, R | 1 |
| Bansinath, M; Bhargava, HN; Das, S; Matwyshyn, GA | 1 |
| Bodnar, RJ; Inturrisi, CE; Kest, B; Truesdell, LS; Yoburn, BC | 1 |
| Pasternak, GW; Recht, LD | 1 |
| Heyman, JS; Mosberg, HI; Mulvaney, SA; Porreca, F | 1 |
| Christie, MJ; North, RA; Williams, JT | 1 |
| Bechara, A; van der Kooy, D; Zito, KA | 1 |
| Bardo, MT; Neisewander, JL | 1 |
| Bykov, V; Holaday, JW; Jacobson, AE; Lessor, RA; McLean, S; Rice, KC; Rothman, RB | 1 |
| Adams, JU; Andrews, JS; Hiller, JM; Holtzman, SG; Simon, EJ | 1 |
| Liebeskind, JC; Pechnick, RN; Terman, GW | 1 |
| Burks, TF; Fox, DA | 1 |
| Larson, DL; Lipkowski, AW; Nagase, H; Portoghese, PS; Takemori, AE | 1 |
| Nagase, H; Portoghese, PS; Takemori, AE | 1 |
| Ho, BY; Naeseth, JS; Portoghese, PS; Takemori, AE | 1 |
| Inturrisi, CE; Luke, MC; Pasternak, GW; Yoburn, BC | 1 |
| James, RC; Millner, GC; Paule, MG; Roberts, SM; Wessinger, WD | 1 |
| Emmanouil, DE; Ishii, MM; Quock, RM | 1 |
| Bykov, V; Danks, JA; Holaday, JW; Jacobson, AE; Long, JB; Rice, KC; Rothman, RB; Tortella, FC | 1 |
| Portoghese, PS; Schwartz, MM; Takemori, AE | 1 |
| Bardo, MT; Ennis, RB; Neisewander, JL | 1 |
| Di Chiara, G; Imperato, A | 1 |
| Katoh, M; Kimura, T; Satoh, S | 1 |
| Carino, MA; Horita, A; Yamawaki, S | 2 |
| Di Chiara, G; Morelli, M | 1 |
| Martin, WR; Wettstein, JG | 1 |
| Hayes, AG; Skingle, M; Tyers, MB | 1 |
| O'Neill, KA; Valentino, D | 1 |
| Akil, H; Houghten, RA; Lewis, ME; Walker, JM; Woods, JH; Young, EA | 1 |
| Lipkowski, AW; Portoghese, PS; Takemori, AE | 1 |
| Flood, JF; Morley, JE | 1 |
| Bansinath, M; Bhargava, HN | 1 |
| Baratti, CM; Introini, IB; McGaugh, JL | 1 |
| Harty, GJ; Onofrio, BM; Yaksh, TL | 1 |
| Devane, GD; Gudelsky, GA; Koenig, JI; Meltzer, HY | 1 |
| Gudelsky, GA; Koenig, JI; Meltzer, HY | 1 |
| Fujimoto, JM; Roerig, SC; Tseng, LF | 1 |
| Gaspari, J; Kleber, HD; Kosten, TR; Topazian, M | 1 |
| Gardner, EL; Tempel, A; Zukin, RS | 1 |
| Fries, DS; Larson, DL; Portoghese, PS; Takemori, AE; Ward, SJ | 1 |
| Cho, TM; Nozaki, M | 1 |
| Eisenberg, RM | 1 |
| Cohen, AH; Goodman, RR; Inturrisi, CE; Pasternak, GW; Yoburn, BC | 1 |
| Faris, PL; Komisaruk, BR; Mayer, AD; Rosenblatt, JS | 1 |
| Mansour, A; Valenstein, ES | 1 |
| Lookingland, KJ; Moore, KE | 2 |
| Hayes, AG; Stewart, BR | 1 |
| Holtzman, SG; Locke, KW | 2 |
| Carr, KD; Feliu, AL; Fowler, JS; Holland, MJ; Simon, EJ | 1 |
| Bell, RD; Cicero, TJ | 1 |
| Cabib, S; Oliverio, A; Puglisi-Allegra, S | 1 |
| Blank, MS; Catt, KJ; Dufau, ML; Fabbri, A | 2 |
| Coscia, CJ; Devane, WA; Howlett, AC; Spain, JW | 1 |
| Botros, S; Lipkowski, AW; Portoghese, PS; Takemori, AE | 1 |
| Greenberg, AH; Kraut, RP | 1 |
| Mayer, DJ; Watkins, LR | 1 |
| Larson, DL; Portoghese, PS; Ronsisvalle, G; Takemori, AE | 1 |
| Depaulis, A; Gale, RP; Liebeskind, JC; Martin, FC; Pechnick, RN; Shavit, Y; Terman, GW; Zane, CJ | 1 |
| McLaughlin, PJ; Zagon, IS | 4 |
| Adler, B; Inturrisi, CE; Nunes, FA; Pasternak, GW; Yoburn, BC | 1 |
| Portoghese, PS; Schoenecker, JW; Takemori, AE | 1 |
| Abood, LG; Dirksen, R; Gala, D; Reichman, M | 1 |
| Hynes, MD; Leander, JD; Reel, JK; Zimmerman, DM | 1 |
| Lieblich, I; Yirmiya, R | 1 |
| Coscia, CJ; Spain, JW | 1 |
| Cunningham, CL; Peris, J; Schwarz, KS | 1 |
| Corrigall, WA; D'Onofrio, RM; Lei, H; Linseman, MA | 1 |
| Miczek, KA; Winslow, JT | 1 |
| Leshem, M | 1 |
| Altman, DG; Barrowcliffe, MP; Jones, JG; Jordan, C; Konieczko, KM | 1 |
| Calligaro, D; Khazan, N; Young, GA | 1 |
| Bryant, HU; Kuta, CC; Story, JA; Yim, GK | 1 |
| Blass, EM; Weller, A | 1 |
| Chinn, C; Horita, A; Yabase, M | 1 |
| Bechara, A; Martin, GM; van der Kooy, D | 1 |
| Evans, RG; Olley, JE | 1 |
| Berg, M; Johansson, B; Meyerson, BJ | 1 |
| Dykstra, LA; Gmerek, DE; Winger, G; Woods, JH | 1 |
| Dixon, R; Simpkins, JW; Smulkowski, M; Tuttle, R | 1 |
| Brocklehurst, C; Devia, C; Moerschbaecher, JM | 1 |
| Harty, GJ; Yaksh, TL | 1 |
| Candeletti, S; Cavicchini, E; Ferri, S; Govoni, P; Marchini, M; Romualdi, P; Speroni, E | 1 |
| Billington, CJ; Brown, DM; Gosnell, BA; Grace, M; Krahn, DD; Levine, AS; Morley, JE | 1 |
| Ikebuchi, H; Kawanishi, T; Nagamatsu, K; Ohno, Y; Takanaka, A; Terao, T | 1 |
| Portoghese, PS; Takahashi, M; Takemori, AE | 1 |
| Stevens, CW; Yaksh, TL | 1 |
| Ben-Eliyahu, S; Gale, RP; Liebeskind, JC; Martin, FC; Shavit, Y; Terman, GW; Weiner, H; Yirmiya, R | 1 |
| Frey, HH | 1 |
| Maier, SF | 1 |
| Agren, H | 1 |
| Galizio, M; Perone, M | 1 |
| Duffy, P; Kalivas, PW | 1 |
| Iakimova, K | 1 |
| Adams, JU; France, CP; Woods, JH | 2 |
| Kouchich, FJ; Panek, RW; Quock, RM; Rosenthal, MA | 1 |
| Morgan, MJ; Pechnick, RN | 1 |
| Arteau, C; Fujimoto, JM; Roerig, SC | 1 |
| Borrell, J; Fuentes, JA; Naranjo, JR; Urdín, MC | 1 |
| Gowans, GC; Grilly, DM | 1 |
| Elsworth, JD; Redmond, DE; Roth, RH | 1 |
| Risner, ME; Shannon, HE; Vaupel, DB | 1 |
| Lira, SA; Phipps, DW; Sarkar, DK | 1 |
| Abbott, P; Kristal, MB; Thompson, AC | 1 |
| de Feo, G; Mazzanti, G; Piccinelli, D | 1 |
| Ferreira, SH; Follenfant, RL; Smith, TW | 1 |
| Cowan, A; Gmerek, DE; Woods, JH | 1 |
| Cohen, AH; Inturrisi, CE; Yoburn, BC | 1 |
| Holmes, LJ; Wise, RA | 1 |
| Garrett, ER | 1 |
| Adler-Graschinsky, E; Martínez, AE | 1 |
| Pittock, F; Randall, J; Rodgers, RJ | 1 |
| Girardot, MN; Holloway, FA | 1 |
| Bapna, JS; Ramaswamy, S; Viswanathan, S | 1 |
| Cowan, A; Gmerek, DE; Ryan, JP | 1 |
| Dykstra, LA | 1 |
| McLaughlin, PJ; Portoghese, PS; Takemori, AE; Zagon, IS | 1 |
| Gmerek, DE; Woods, JH | 1 |
| Chiang, CN; Foltz, RL; Gillespie, HK; Hollister, LE | 1 |
| Fatherazi, S; Horita, A; Kazi, S; Lai, H | 1 |
| Galbraith, JA; Mickley, GA; Stevens, KE | 1 |
| Grishkat, HL; Kristal, MB; Thompson, AC | 1 |
| Berg, M; Meyerson, BJ | 1 |
| Jacobson, AE; Rice, KC; Sadée, W; Yu, VC | 1 |
| Larson, DL; Portoghese, PS; Sayre, LM; Takemori, AE | 1 |
| Cicero, TJ; Meyer, ER; Owens, DP; Schmoeker, PF | 1 |
| Briski, K; Meites, J; Quigley, K | 1 |
| DeLander, GE; Portoghese, PS; Takemori, AE | 1 |
| Bernardini, GL; Clark, WG; Pang, IH | 1 |
| Dickinson, SL; Longman, DA; Slater, P | 1 |
| Portoghese, PS; Takemori, AE; Ward, SJ | 2 |
| Herz, A; Millan, MH; Millan, MJ; Przewłocki, R | 1 |
| Bajorek, JG; Lee, RJ; Lomax, P | 1 |
| Nijkamp, FP; Sitsen, JM | 1 |
| Armstrong, MJ; Larson, AA | 1 |
| Bohus, B; De Wied, D; Kovàcs, GL | 1 |
| France, CP; Jacobson, AE; Woods, JH | 2 |
| Simon, EJ; Smith, JR | 1 |
| Appel, JB; Hernández, LL | 1 |
| Clemens, JA; Shaar, CJ | 1 |
| Fratta, W; Grandison, L; Guidotti, A | 1 |
| Farsang, C; Kunos, G; Mucci, L; Ramirez-Gonzalez, MD | 1 |
| Bell, JA; Berry, JN; Sharpe, LG | 1 |
| Hahnenberger, RW | 1 |
| Holtzman, SG; Teal, JJ | 4 |
| Herling, S; Medzihradsky, F; Merz, H; Valentino, RJ; Woods, JH | 1 |
| Frenk, H; Urca, G; Yitzhaky, J | 1 |
| Ayhan, IH; Portoghese, PS; Takemori, AE; Tulunay, FC | 1 |
| Byrne, WL; Codd, EE | 1 |
| Dum, JE; Herz, A | 1 |
| Gurll, NJ; Lechner, R; Reynolds, DG; Vargish, T | 1 |
| Messing, RB; Portoghese, PS; Sparber, SB; Takemori, AE | 1 |
| Harris, RA; Snell, D | 1 |
| Pasternak, GW | 1 |
| Johnson, JH | 1 |
| Cools, AR; Megens, AA | 1 |
| Ashcraft, LJ; Drugan, RC; Grau, JW; Hyson, RL; Maier, SF | 1 |
| Balamuth, R; Frenk, H; Liban, A; Urca, G | 1 |
| Takemori, AE; Ward, SJ | 1 |
| Brown, DR; Holtzman, SG; Locke, KW | 1 |
| Nof, A; Sarne, Y; Urca, G; Weissman, BA | 1 |
| Amir, S; Simantov, R | 1 |
| Grevel, J; Sadée, W | 1 |
| Vaupel, DB | 1 |
| Amir, S | 3 |
| Kameyama, T; Ukai, M | 1 |
| Bardo, MT; Bhatnagar, RK; Gebhart, GF | 1 |
| Angel, L; Inturrisi, CE; Schultz, M; Shin, S; Simon, EJ; Umans, JG | 1 |
| Griffiths, EC; Slater, P; Widdowson, PS | 1 |
| Frenk, H; Mayer, DJ; Miller, J; Watkins, LR | 1 |
| Frenk, H; Stein, BE | 1 |
| Koenig, JI; Krulich, L; Mayfield, MA; McCann, SM | 1 |
| Castellano, C; Csányl, V; Dóka, A; Oliverio, A; Puglisi-Allegra, S | 1 |
| Briski, KP; Meites, J; Quigley, K | 1 |
| Herling, S; Solomon, RE; Valentino, RJ; Woods, JH | 1 |
| Carr, KD | 1 |
| Evans, BD; Greenstein, RA; McLellan, AT; O'Brien, CP | 1 |
| Gmerek, D; Woods, JH | 1 |
| Liebeskind, JC; Morgan, MJ; Pechnick, RN | 1 |
| Barela, P; Schnur, P | 1 |
| Katz, RJ; Manik, CP | 2 |
| Wiesenfeld-Hallin, Z | 1 |
| Amir, S; Harel, M | 2 |
| Brown, DR; Chang, EB; Field, M; Miller, RJ | 1 |
| Beatty, WW | 1 |
| Frischknecht, HR; Riggio, G; Siegfried, B; Waser, PG | 1 |
| Anggård, E; Jones, AW; Neri, A | 1 |
| Krystal, JH; Redmond, DE | 1 |
| Brown, DR; Goldberg, LI; Robertson, MJ | 1 |
| Delander, GE; Takemori, AE | 1 |
| Gale, RP; Lewis, JW; Liebeskind, JC; Shavit, Y; Terman, GW | 1 |
| Derendorf, H; El-Din, A; El-Koussi, A; Garrett, ER | 1 |
| Sharon, AC; Wise, DL | 1 |
| Archer, S | 1 |
| Michael, RP; Schaefer, GJ | 1 |
| Domino, EF; Ruffing, DM | 1 |
| Byrd, LD | 1 |
| Critcher, EC; Lin, CI; Myers, RD; Patel, J | 1 |
| Cooper, SJ | 3 |
| Cannon, JT; Lewis, JW; Liebeskind, JC | 1 |
| Franklin, SR; Tang, AH | 1 |
| Coale, EH; Hein, DW; Herling, S; Valentino, RJ; Woods, JH | 1 |
| Herling, S; Woods, JH; Young, AM | 1 |
| Woods, JH; Young, AM | 1 |
| Maas, CL | 1 |
| Cochin, J; Miller, JM; Poulsen-Burke, J; Rosow, CE | 1 |
| Berman, RF; Eggleton, CE; Stone, WS | 1 |
| Lewis, JW; Liebeskind, JC; Sherman, JE; Tordoff, MG | 1 |
| Bianchi, G; Fiocchi, R; Manara, L; Tavani, A | 1 |
| Blumberg, H; Slovak, DM | 1 |
| Cicero, TJ; Meyer, ER; Schmoeker, PF | 1 |
| Bree, MP; Mello, NK; Mendelson, JH | 1 |
| Bass, P; Goldberg, LI; Merz, H; Russell, J; Schuster, CR | 1 |
| Goldberg, DM; Goldberg, SR; Morse, WH | 1 |
| Maes, RA; Plomp, GJ; van Ree, JM | 1 |
| Holtzman, SG; White, JM | 1 |
| Brown, DR; Holtzman, SG | 1 |
| Advokat, C | 1 |
| Lal, H; Numan, R | 1 |
| Olds, ME; Williams, KN | 1 |
| Buchsbaum, MS; Bunney, WE; Davis, GC | 1 |
| Frenk, H; Urca, G | 1 |
| DeWitt, L; Minnema, DJ; Rosecrans, JA | 1 |
| Culpepper-Morgan, JA; Holt, PR; Kreek, MJ; LaRoche, D | 1 |
| Auerbach, SB; Tao, R | 2 |
| Kalso, EA; Kontinen, VK | 1 |
| Crain, SM; Shen, KF | 5 |
| Bilsky, EJ; French, ED; Glick, SD; Menkens, KA; Porreca, F; Reid, LD | 1 |
| Bhargava, HN; House, RV; Thomas, PT; Thorat, SN | 1 |
| Krause, JE; McCarson, KE | 1 |
| Archer, S; Glick, SD; Maisonneuve, IM; Raucci, J | 1 |
| Carboni, L; Gomez-Vidal, JA; Marrazzo, A; Pasquinucci, L; Prezzavento, O; Ronsisvalle, G; Spampinato, S; Vittorio, F | 1 |
| Drukarch, B; Goosen, C; Sahadat, MC; Schoffelmeer, AN; Stoof, JC; Vermeulen, RJ; Wolters, EC | 1 |
| Brodsky, M; Elliott, K; Hynansky, A; Inturrisi, CE | 1 |
| Endoh, T; Misawa, M; Mori, T; Nagase, H; Suzuki, T; Tsuji, M | 2 |
| Brodsky, M; Inturrisi, CE; Rasmussen, K | 1 |
| Alsasua, A; Martín, MI; Parra, L; Pérez-Vizcaíno, F; Tamargo, J | 1 |
| Iwamoto, Y; Kamei, J; Kasuya, Y; Misawa, M; Nagase, H; Ohsawa, M; Saitoh, A; Suzuki, T | 1 |
| Goldenheim, PD; Grandy, RP; Kaiko, RF; Reder, RF; Sackler, RS | 1 |
| Adler, MW; Bussiere, JL; Eisenstein, TK; Geller, EB; Meissler, JJ; Rogers, TJ | 1 |
| Bennett, EH; Coussons, ME; Dykstra, LA; Lysle, DT; Watts, VJ | 2 |
| Lai, J; Porreca, F; Vanderah, TW; Yamamura, HI | 1 |
| Martín, MI; Milanés, MV; Vargas, ML | 1 |
| Diop, L; Junien, JL; Pascaud, X; Rivière, PJ | 1 |
| Carr, DJ; Garza, HH; Prakash, O | 1 |
| Kovelowski, CJ; Ossipov, MH; Porreca, F | 1 |
| Blommaert, A; Fournié-Zaluski, MC; Noble, F; Roques, BP | 1 |
| Noble, F; Roques, BP | 1 |
| Carpenter, GW; Carr, DJ | 1 |
| Maity, R; Mukherjee, R; Skolnick, P | 1 |
| Foss, JF; Moss, J; Yuan, CS | 1 |
| Kamei, J; Kasuya, Y; Misawa, M; Nagase, H; Ohsawa, M | 2 |
| Dhawan, KN; Gupta, MB; Nath, C; Patnaik, GK | 1 |
| Murison, R; Overmier, JB | 1 |
| Coussons-Read, ME; Dykstra, LA; Lysle, DT | 1 |
| Holtzman, S; White-Gbadebo, D | 1 |
| Moerschbaecher, JM; Pakarinen, ED; Woods, JH | 1 |
| Iwamoto, Y; Kamei, J; Kasuya, Y; Kawashima, N; Misawa, M; Nagase, H; Suzuki, T | 1 |
| Haney, M; Miczek, KA | 1 |
| Kamei, J; Misawa, M; Mizoguchi, H; Nagase, H; Suzuki, T; Yoshiike, M | 1 |
| Funada, M; Misawa, M; Nagase, H; Narita, M; Suzuki, T | 3 |
| Bayer, BM; Flores, LR; Wahl, SM | 1 |
| Kovelowski, CJ; Ossipov, MH; Porreca, F; Vanderah, T | 1 |
| Fujimoto, JM; Rady, JJ | 1 |
| Guirimand, F; Le Bars, D; Strimbu-Gozariu, M; Willer, JC | 1 |
| Isaac, L; Ristic, H | 1 |
| Nishiyama, N; Schwartz, JP; Taniwaki, T; Wilson, D | 1 |
| Barg, J; Belcheva, MM; Coscia, CJ; Johnson, FE; Levy, R; McHale, RJ; Saya, D; Vogel, Z; Zimlichman, R | 1 |
| Freier, DO; Fuchs, BA | 2 |
| Wong, CL | 1 |
| Kishioka, S; Masuda, Y; Miyamoto, Y; Ozaki, M; Yamamoto, H | 1 |
| House, JD; Makhay, MM; Walker, EA; Young, AM | 1 |
| Benoliel, JJ; Bourgoin, S; Cesselin, F; Collin, E; Hamon, M; Mauborgne, A | 1 |
| Nelson, E; Panksepp, J; Siviy, S | 1 |
| Azorlosa, JL | 1 |
| Dykstra, LA; Pitts, RC | 1 |
| Fleshner, M; Laudenslager, ML; Lockwood, LL; Maier, SF; Silbert, LH; Watkins, LR | 1 |
| Hitosugi, H; Iwamoto, Y; Kamei, J; Kasuya, Y; Misawa, M; Nagase, H | 1 |
| Brune, K; Geisslinger, G; Schmidt, N | 1 |
| Bailey, MD; Bhargava, HN; Bozek, PS; Gerk, PM; Ko, KH; Matwyshyn, GA; Simko, RJ; Thorat, SN | 1 |
| Bhargava, HN; Matwyshyn, GA; Reddy, PL; Thorat, SN | 1 |
| Bowen, WD; Miyamoto, Y; Portoghese, PS; Takemori, AE | 1 |
| Dassaud, M; Diop, L; Junien, JL; Pascaud, X; Rivière, PJ | 1 |
| Randich, A; Robertson, JD; Willingham, T | 1 |
| Aksu, F; Fujimoto, JM; Holmes, BB | 1 |
| Bhargava, HN; Matwyshyn, GA; Reddy, PL | 1 |
| Hamann, SR; Martin, WR | 1 |
| Maier, SF; Mooney-Heiberger, K; Watkins, LR; Wiertelak, EP; Yang, HY | 1 |
| Amin, HM; Camporesi, EM; Esposito, BF; Foss, JF; Roizen, MF; Sopchak, AM | 1 |
| Hirokami, M; Ikeda, T; Matsumoto, M; Saito, H; Smith, CB; Tochihara, M; Togashi, H; Yoshioka, M | 1 |
| Gottreich, A; Homonnai, ZT; Oppenheim, D; Paz, G; Yavetz, H; Yogev, L | 1 |
| Capasso, A; Cutrufo, C; Di Giannuario, A; Loizzo, A; Palazzesi, S; Pieretti, S; Sorrentino, L | 1 |
| Brusa, L; D'Amore, A; Lorenzini, P; Massotti, M | 1 |
| Kavaliers, M; Saucier, DM | 1 |
| Carr, DJ; France, CP; Gerak, LR | 1 |
| Leeb, K; Parker, L | 1 |
| Holtzman, SG; White-Gbadebo, D | 1 |
| Amundsen, L; Binstock, W; Cox, SM; Faure, EA; Glosten, B; Hibbard, J; Ismail, M; Moawad, AH; Senal, JA; Wittels, B | 1 |
| Kaneto, H; Takahashi, M; Tokuyama, S | 1 |
| Holtzman, SG; Woolfolk, DR | 1 |
| Ellis, EF; Embrey, JP; Uphouse, LA; Ward, CR; Welch, SP | 1 |
| Brown, RD; Fuchs, BA; Harris, LS; Levier, DG; McCay, JA; Munson, AE | 1 |
| Chang, KJ; Comer, SD; De Costa, BR; McNutt, RW; Mosberg, HI; Woods, JH | 1 |
| Hua, M; Larson, DL; Portoghese, PS; Takemori, AE | 1 |
| Bodnar, RJ; Kiefel, JM; Rossi, GC | 1 |
| Hubbell, CL; McCutcheon, NB | 1 |
| Davis, T; Duttaroy, A; Shah, S; Yoburn, BC | 1 |
| Barg, J; Belcheva, MM; Coscia, CJ; Johnson, FE; Levy, R; McHale, RJ; McLachlan, JA; Vogel, Z | 1 |
| Holtzman, SG; Paronis, CA; Waddell, AB | 1 |
| Bardo, MT; Kolta, MG | 1 |
| Adler, MW; Bussiere, JL; Eisenstein, TK; Rogers, TJ; Rojavin, M; Szabo, I | 1 |
| Al, Y; Butelman, ER; Negus, SS; Woods, JH | 1 |
| Lanthorn, TH; Watson, GB | 1 |
| Dosaka-Akita, K; Holaday, JW; Long, JB; Tortella, FC | 1 |
| Hammer, RP; Seatriz, JV | 1 |
| Nejat, RJ; Pasternak, GW; Pick, CG | 1 |
| Bull, PM; Clarke, G; Douglas, AJ; MacMillan, SJ; McGrory, BG; Neumann, I; Russell, JA; Way, SA; Wright, DM | 1 |
| Amico, MC; Morrone, LA; Romanelli, L; Valeri, P | 1 |
| De Vries, TJ; Mulder, AH; Schoffelmeer, AN; Tjon Tien Ril, GH; Van der Laan, JW | 1 |
| Bourgoin, S; Cesselin, F; Collin, E; Frechilla, D; Hamon, M; Le Bars, D; Pohl, M | 1 |
| Miyamoto, Y; Portoghese, PS; Takemori, AE | 1 |
| Tiseo, PJ; Yaksh, TL | 1 |
| Shippenberg, TS; Spanagel, R | 1 |
| Adams, ML; Cicero, TJ; Forman, JB; Meyer, ER; Sewing, B | 1 |
| Desmeules, JA; Gacel, G; Guilbaud, G; Kayser, V; Roques, BP | 1 |
| Andres-Trelles, F; Baamonde, A; Hidalgo, A; Menendez, L | 1 |
| Funada, M; Misawa, M; Nagase, H; Narita, M; Suzuki, T; Takahashi, Y; Takamori, K | 1 |
| Matsumoto, M; Saito, H; Smith, CB; Togashi, H; Yoshioka, M | 1 |
| Baumhaker, Y; Gafni, M; Keren, O; Sarne, Y | 1 |
| Iwamoto, Y; Kamei, J; Kasuya, Y; Misawa, M; Nagase, H; Suzuki, T | 1 |
| Cheng, PY; Decena, JA; McCabe, S; Soong, Y; Szeto, HH; Wu, D | 1 |
| Adams, JU; Adler, MW; Geller, EB; Tallarida, RJ | 1 |
| Kest, B; Liebeskind, JC; Mogil, JS; Sadowski, B; Sternberg, WF | 1 |
| Bass, AS; Foss, JF; Goldberg, LI | 1 |
| Lipinsky, D; Oron, Y; Sarne, Y | 1 |
| Bhargava, HN; Larsen, AK; Rahmani, NH; Villar, VM | 2 |
| Cobbe, SM; Hicks, MN; Oldroyd, KG | 1 |
| Bendotti, C; Bertelli, A; Di Giulio, AM; Germani, E; Gorio, A; Mantegazza, P | 1 |
| Fleshner, M; Grisel, JE; Maier, SF; Watkins, LR | 1 |
| Bashaw, ED; Goldenheim, PD; Grandy, RP; Kaiko, RF; Reder, RF | 1 |
| Misawa, M; Mori, T; Nagase, H; Suzuki, T; Tsuji, M | 1 |
| Hawranko, AA; Monroe, PJ; Smith, DJ; Smith, DL | 1 |
| Akil, H; Bronstein, DM; Sanchez, IO; Trujillo, KA | 1 |
| Minetti, M; Pacifici, R; Pietraforte, D; Zuccaro, P | 1 |
| Fritzinger, BK; Heller, J; Nakayama, GR; Roskos, KV | 1 |
| Gulati, K | 1 |
| Fritzinger, BK; Heller, J; Nakayama, GR; Roskos, KV; Tefft, JA | 1 |
| Nestler, EJ; Nye, HE | 1 |
| Foss, JF; Moss, J; O'Connor, M; Roizen, MF; Toledano, A; Yuan, CS | 1 |
| Dykstra, LA; Fecho, K; Lysle, DT; Maslonek, KA | 1 |
| Mendez, M; Miranda, HF; Pinardi, G; Sierralta, F | 1 |
| Adams, ML; Cicero, TJ; Meyer, ER | 2 |
| Basbaum, AI; Detweiler, DJ; Rohde, DS | 1 |
| Carden, SE; Hernandez, N; Hofer, MA | 1 |
| Karasawa, F; Kitani, Y; Kuribara, H; Morita, T; Sato, T; Uchihashi, Y | 1 |
| Chahl, LA; Herdegen, T; Leah, J; Lynch-Frame, AM; Trueman, L | 1 |
| Funada, M; Schutz, CG; Shippenberg, TS | 1 |
| Kamei, J; Morita, K; Nagase, H; Saitoh, A; Suzuki, T | 1 |
| Chao, CC; Gekker, G; Hu, S; Molitor, TW; Peterson, PK; Sheng, WS | 1 |
| Barr, GA; Jones, KL | 3 |
| Carr, DJ; Scott, M | 1 |
| Grouhel, A; Wettstein, JG | 1 |
| Gahn, LG; Sevarino, KA | 1 |
| Gouardères, C; Jhamandas, K; Sutak, M; Zajac, JM | 1 |
| Feng, YZ; Ho, IK; Rockhold, RW; Tokuyama, S; Zhang, T; Zhu, H | 1 |
| Bianchi, M; Panerai, AE; Sacerdote, P | 1 |
| Foss, JF; Goldberg, LI; Orelind, E | 1 |
| Kalin, NH; Lynn, DE; Shelton, SE | 1 |
| Cox, BM; Izenwasser, S; Katz, JL; Newman, AH | 1 |
| Hitz, S; Jackson, IM; Lechan, RM; Légrádi, G; Nillni, EA; Rand, WM | 1 |
| Cook, CD; Morgan, D; Negus, SS; Picker, MJ | 1 |
| Feng, J; Kendig, JJ | 1 |
| Bot, G; Chahl, LA | 1 |
| Ahtee, L; Piepponen, TP | 1 |
| Besson, JM; Buritova, J; Honoré, P | 1 |
| Baldwin, AE; Cannon, TJ | 1 |
| Aghajanian, GK; Kendrick, WT; Kogan, JH; Rasmussen, K | 1 |
| Adler, MW; Chen, XH; de Riel, JK; Geller, EB; Liu-Chen, LY; Tallarida, RJ | 1 |
| Catheline, G; Guilbaud, G; Kayser, V | 1 |
| Henderson, CA; Reynolds, JE | 1 |
| Hurwitz, A; Kimler, BF; Li, Y; Looney, GA | 1 |
| Javelle, N; Lambás-Señas, L; Renaud, B | 1 |
| Fuentes, JA; Reche, I; Ruiz-Gayo, M | 1 |
| Kristal, MB; Thompson, AC | 1 |
| Angel, F; Chevalier, E; Dahl, SG; Friese, N; Junien, JL; Pascaud, X; Riviere, PJ | 1 |
| Inturrisi, CE; Kest, B; Lee, CE; Mogil, JS | 1 |
| Luján Estrada, M; Medina Jiménez, M; Rodríguez, R | 1 |
| Ho, ST; Lee, SC; Tao, PL; Wang, JJ | 1 |
| Easterling, KW; Holtzman, SG | 4 |
| Castelli, MP; Diaz, G; Fadda, P; Gessa, GL; Mameli, M; Melis, M | 1 |
| Chao, CC; Gekker, G; Hu, S; Lipovsky, MM; Molitor, TW; Peterson, PK; Sowa, G | 1 |
| Ho, IK; Hoshi, K; Ma, T; Oh, S | 1 |
| Foss, JF; Moss, J; Osinski, J; Roizen, MF; Toledano, A; Yuan, CS | 1 |
| Glick, SD; Maisonneuve, IM; Pearl, SM | 1 |
| Barg, J; Eilam, Y; Ela, C; Hasin, Y; Vogel, Z | 1 |
| Aarnisalo, AA; Idänpään-Heikkilä, JJ; Kalso, E; Kontinen, VK; Panula, P | 1 |
| Dykstra, LA; Hughes, CE | 1 |
| Gingras, J; Hepburn, MJ; Kuhn, CM; Little, PJ | 1 |
| Adler, MW; Eisenstein, TK; Hilburger, ME; Meissler, JJ; Rogers, TJ; Satishchandran, V; Truant, AL | 1 |
| Manfredi, B; Mantegazza, P; Panerai, AE; Sacerdote, P | 1 |
| Paronis, CA; Woods, JH | 1 |
| Coulais, Y; Francés, B; Goeldner, M; Guiraud, R; Hirth, C; Méjean-Galzi, A; Tafani, JA; Zajac, JM | 1 |
| Bhargava, HN; Kumar, S | 1 |
| Brown, GP; Chang, A; King, MA; Leventhal, L; Pasternak, GW; Rossi, GC; Yang, K | 1 |
| Barr, GA; Goodwin, GA | 1 |
| Brandt, MR; Cabansag, SR; France, CP | 1 |
| Lê, AD; Linseman, MA | 1 |
| Caggiula, AR; Di Pirro, JM; Kristal, MB; Robinson-Vanderwerf, TM | 1 |
| Ahtee, L; Katajamäki, J; Kivastik, T; Piepponen, TP; Zharkovsky, A | 1 |
| Rothe, KS; Stevens, CW | 1 |
| Gross, GJ; Hsu, AK; Schultz, JJ | 1 |
| Warneke, L | 1 |
| Hermini, AH; Pereira, DG; Teixeira, NA | 1 |
| Burke, TF; Garner, HR; Lawhorn, CD; Stoner, JM; Wessinger, WD | 1 |
| Dahl, SG; Diop, L; Friese, N; Lambert, C; Rivière, PJ | 1 |
| Stevens, CW; Willenbring, S | 1 |
| Józefowski, S; Płytycz, B | 1 |
| Hytrek, SD; McLaughlin, PJ; Tobias, SW; Zagon, IS | 1 |
| Hernandez, AV; Norton, JA; Storrow, AB | 1 |
| He, Z; Ho, IK; Tsang, BK; Wongchanapai, W | 1 |
| Makhay, MM; Poling, A; Young, AM | 1 |
| Aasmundstad, TA; Alkana, RL; Grung, M; Handal, M; Mørland, J; Skurtveit, S | 1 |
| Appleyard, SM; Davis, TP; Hruby, VJ; Knapp, RJ; Lipkowski, AW; Misicka, A; Slaninova, J; Weber, SJ; Yamamura, HI | 1 |
| Desprat, C; Zajac, JM | 1 |
| Cruz-Madorran, I; Flecknell, PA; Liles, JH; Roughan, J | 1 |
| Basbaum, AI; Rohde, DS | 1 |
| Bayer, BM; Mellon, RD | 2 |
| Fujimoto, JM; Holmes, BB; Rady, JJ | 1 |
| Arneric, SP; Bannon, AW; Buckley, MJ; Decker, MW; Holladay, MW; Kim, DJ; Lin, NH; Ryther, KB; Wasicak, JT; Williams, M | 1 |
| Brandt, MR; France, CP; Gerak, LR | 1 |
| Bagley, JR; Brockunier, LL; France, CP; Gauthier, CA; Gerak, LR | 1 |
| Balster, RL; Beardsley, PM; Bespalov, AY | 1 |
| Auerbach, SB; Ma, Z; Tao, R | 1 |
| Chang, SL; Graf, JA; Wu, GD; Zadina, JE | 1 |
| Elde, R; Kshirsagar, T; Law, PY; Nakano, AH; Portoghese, PS | 1 |
| Kizawa, Y; Koike, K; Okayasu, A; Suzuki, T; Takayanagi, I | 1 |
| Matsuzawa, S; Misawa, M; Nagase, H; Suzuki, T | 2 |
| Foss, JF; Goldberg, LI; Roizen, MF; Yuan, CS | 1 |
| Cheung, P; Li, JG; Liu-Chen, LY; Raffa, RB; Tzeng, TB | 1 |
| Barke, RA; Loh, HH; Roy, S | 1 |
| Foss, JF; Moss, J; O'Connor, M; Osinski, J; Roizen, MF; Yuan, CS | 1 |
| Morgan, D; Picker, MJ | 1 |
| Alvarez-Fuentes, J; Caraballo, I; Fernández-Arévalo, M; Holgado, MA; Melgoza, LM; Millán, M; Rabasco, AM | 1 |
| Pol, O; Puig, MM | 1 |
| Murphy, DB; Murphy, MB | 1 |
| Fujimoto, JM; Gorny, JM; Rady, JJ | 1 |
| Balster, RL; Beardsley, PM; Bespalov, AY; Bowen, SE; Tokarz, ME | 1 |
| Alberti, I; Fernández, B; Kitchen, I; Paz Viveros, M | 1 |
| Kishimoto, Y; Misawa, M; Nagase, H; Suzuki, T; Takeda, F | 1 |
| Bartok, RE; Craft, RM; Heideman, LM | 1 |
| Besson, JM; Catheline, G; Le Guen, S | 1 |
| Minami, M; Nakagawa, T; Ozawa, T; Satoh, M; Watanabe, T | 1 |
| Chehade, J; Duffy, L; Gajraj, N; Johnson, ER; Joshi, GP; Wesevich, J | 1 |
| Koyuncuoglu, H; Nurten, A; Nurten, R; Yamantürk, P | 1 |
| Rasmussen, K; Vandergriff, J | 1 |
| Foss, JF; Yuan, CS | 1 |
| Grigdesby, CF; March, PA; Suckow, MA; Terril, LA | 1 |
| Kuwagama, K; Pugh, CR; Rudy, JW | 1 |
| Gross, GJ; Liang, BT | 1 |
| France, CP; Gauthier, CA | 1 |
| Minami, M; Nakagawa, T; Ozawa, T; Satoh, M | 1 |
| Maslov, LN; Naryzhnaya, NV; Tam, SW | 1 |
| Chen, C; de Riel, JK; DesJarlais, RL; Li, JG; Liu-Chen, LY; Matecka, D; Rice, K; Yin, J; Zhang, Y | 1 |
| Frankel, PS; Garcia, MM; Harlan, RE | 2 |
| Grech, DM; Platt, DM; Rowlett, JK; Spealman, RD | 1 |
| Coudoré-Civiale, MA; Courteix, C; Eschalier, A; Fialip, J; Privat, AM; Zajac, JM | 1 |
| Becker, C; Benoliel, JJ; Cesselin, F; Hamon, M | 1 |
| Ananthan, S; Bilsky, EJ; Carter, RL; Davis, P; Dersch, CM; Kezar, HS; Porreca, F; Rice, KC; Rothman, RB; Saini, SK; Wells, JL; Xu, H | 1 |
| Grahn, RE; Maier, SF; Maswood, S; McQueen, MB; Watkins, LR | 1 |
| Dykstra, LA; Hawkins, ER; Picker, MJ; Tiano, MJ; Walker, EA | 1 |
| Castellano, C; Cestari, V; Ciamei, A | 1 |
| How, T; Lysle, DT; Nelson, CJ | 1 |
| Hori, T; Hosoi, M; Kamikawa, H; Katafuchi, T; Yamamoto, T | 1 |
| Izzo, E; King, M; Koob, GF; Pasternak, GW; Walker, JR | 1 |
| Anseloni, VC; Brandão, ML; Coimbra, NC; Morato, S | 1 |
| Alberti, I; Fernández, B; Kitchen, I; Viveros, MP | 1 |
| Lohmann, AB; Welch, SP | 1 |
| Alvaro, JD; Chen, YL; Duman, RS; Iredale, PA; Lee, Y; Terwilliger, R | 1 |
| Sutherland, J; Walker, EA; Young, AM; Zhang, L | 1 |
| Goto, K; Ishige, A; Komatsu, Y; Omiya, Y | 1 |
| Ajayi, AA; Onigbogi, O; Ukponmwan, OE | 1 |
| Crain, SM; Shen, K | 1 |
| Allescher, HD; Brechmann, C; Hahn, A; Schusdziarra, V; Storr, M | 1 |
| Bilecki, W; Höllt, V; Przewłocki, R | 1 |
| Ko, MC; Naughton, NN | 1 |
| Belozertseva, IV; Bespalov, AY; Danysz, W | 1 |
| Castells, MT; Laorden, ML; Martínez, MD; Martínez, PJ; Milanés, MV | 1 |
| Easterling, KW; Holtzman, SG; Plovnick, RM | 1 |
| Adler, MW; Eisenstein, TK; Geller, EB; MacFarlane, AS; Meissler, JJ; Peng, X; Rogers, TJ | 1 |
| Esashi, A; Kisara, K; Nakagawasai, O; Niijima, F; Sakurada, S; Tadano, T; Takahashi, N; Tan-No, K; Yonezawa, A | 1 |
| Bagley, JR; Brockunier, LL; France, CP; Gauthier, CA | 1 |
| Haile, CN; Jatlow, P; Kosten, TA | 1 |
| McNally, GP; Westbrook, RF | 1 |
| Misawa, M; Mizoguchi, H; Nagase, H; Narita, M; Suzuki, T; Takahashi-Nakano, Y; Tseng, LF; Yajima, Y | 1 |
| Foss, JF; Karrison, T; Moss, J; O'Connor, M; Osinski, J; Roizen, MF; Yuan, CS | 1 |
| Fujimoto, JM; Holmes, BB; Portoghese, PS; Rady, JJ | 1 |
| Berntsson, A; Eirefelt, M; Söderpalm, B; Svensson, AI | 1 |
| Fudala, PJ; Heishman, SJ; Henningfield, JE; Johnson, RE; Jones, HE | 1 |
| Balestra, B; Brecha, NC; D'Agostino, G; Fiori, E; Minnis, J; Sternini, C; Tonini, M | 1 |
| Kishioka, S; Paronis, CA; Woods, JH | 1 |
| Lee, SC; Yoburn, BC | 1 |
| Parikh, K; Picciotto, MR; Thome, J; Zachariou, V | 1 |
| Sadée, W; Surratt, CK; Wang, D | 1 |
| Aston-Jones, G; Druhan, JP; Walters, CL | 2 |
| Zhang, HT | 1 |
| Gibbons, N; Kapasi, AA; Mattana, J; Singhal, PC | 1 |
| Barr, GA; Zhu, H | 2 |
| Altememi, GF; Mandyam, CD; Standifer, KM | 1 |
| Broadbear, JH; Burke, TF; Husbands, SM; Lewis, JW; Sumpter, TL; Traynor, JR; Woods, JH | 1 |
| Akil, H; Bonner, G; Meng, F | 1 |
| Calderon, SN; Hutchinson, AC; Randall, JF; Rice, KC; Riley, AL; Simpson, GR; Zhang, X | 1 |
| Cañadas, F; Rice, KC; Riley, AL; Stevenson, GW; Zhang, X | 1 |
| Bakshi, VP; Fleming, S; Holahan, MR; Kelley, AE | 1 |
| Chadzinska, M; Plytycz, B; Scislowska-Czarnecka, A | 1 |
| Carrigan, KA; Lysle, DT; Nelson, CJ | 1 |
| Adler, MW; Eisenstein, TK; Meissler, JJ; Mosser, DM; Peng, X; Rogers, TJ | 1 |
| Aceto, MD; Coop, A; Harris, LS; Jacobson, AE; Rice, KC; Traynor, JR; Woods, JH | 1 |
| Cui, CL; Han, JS; Wu, LZ | 1 |
| Kuzmin, A; Ogren, SO; Sandin, J; Terenius, L | 1 |
| Beinborn, M; Carr, DB; Foran, SE; Kopin, AS; Kream, RM; Lipkowski, AW; Marchand, JE; Maszczynska, I; Misicka, A | 1 |
| Chieng, B; Christie, MJ; Osborne, PB | 1 |
| Chao, CC; Hegg, CC; Hu, S; Peterson, PK; Thayer, S | 1 |
| Cicero, TJ; Nock, B; O'Connor, LH; Wich, M | 1 |
| Barr, GA; McPhie, AA | 2 |
| Georges, F; Le Moine, C; Stinus, L | 1 |
| Pol, O; Puig, MM; Valle, L | 1 |
| Holtzman, SG; Powell, KR | 1 |
| Dello Buono, FA; Friedman, JD | 1 |
| Brandão, ML; Nobre, MJ; Sante, AB | 1 |
| Kieffer, BL; Maldonado, R; Matthes, HW; Melchiorri, P; Negri, L; Severini, C | 1 |
| Matsumiya, T; Nagase, H; Narita, M; Suzuki, T; Takeda, H; Tsuji, M | 1 |
| Lysle, DT; Nelson, CJ | 1 |
| Fujimoto, JM; Holmes, BB; Rady, JJ; Tseng, LF | 1 |
| Bodnar, RJ; Hadjimarkou, MM; Pasternak, GW; Rossi, GC; Silva, RM | 1 |
| Endoh, T; Izumimoto, N; Kamei, J; Mizoguchi, H; Nagase, H; Narita, M; Saitoh, A; Suzuki, T; Tajima, A; Tseng, LF | 1 |
| Neilan, CL; Nguyen, TM; Pasternak, GW; Schiller, PW | 1 |
| Holtzman, SG; White, DA | 3 |
| Liu, JG; Prather, PL | 2 |
| Bilsky, EJ; Raehal, KM; Sadée, W; Wang, D | 1 |
| Lucas, JL; Quillan, JM; Sadée, W; Wang, D; Winans, K | 1 |
| Ananthan, S; Lu, YF; Rice, KC; Rothman, RB; Xu, H | 1 |
| Kolaczkowska, E; Plytycz, B; Seljelid, R | 1 |
| Barn, DR; Caulfield, WL; Cottney, J; McGurk, K; Morphy, JR; Rankovic, Z; Roberts, B | 1 |
| Bidlack, JM; Chuang, LF; Chuang, RY; Doi, RH; Suzuki, S | 1 |
| Gurwell, JA; Hauser, KF; Knapp, PE; Martin, K; Ryan, S; Smith, FL; Stiene-Martin, A; Thornton, SR | 1 |
| Alvarez-Fuentes, J; Fernández -Arévalo, M; Holgado, MA; Micó, JA; Rojas -Corrales, MO; Sánchez-Lafuente, C | 1 |
| Adler, MW; Cowan, A; Eisenstein, TK; Gaughan, J; Geller, EB; Meissler, JJ; Rahim, RT; Rogers, TJ | 1 |
| Kane, EC; Williams, KL; Woods, JH | 1 |
| Adler, MW; Eisenstein, LK; Hilburger, ME; MacFarland, AS; Meissler, LJ; Peng, X; Rahim, RT; Rogers, TJ; Wan, AC | 1 |
| Chuang, LF; Chuang, RY; Chuang, TK; Doi, RH; Suzuki, S | 1 |
| He, GA; Hou, HM; Liu, XJ | 1 |
| Foss, JF; Karrison, T; O'Connor, M; Osinski, J; Wei, G; Yuan, CS | 1 |
| Bayer, BM; Houghtling, RA | 1 |
| Foss, JF | 1 |
| Douglas, SD; Guo, CJ; Ho, WZ; Li, Y; Tian, S; Wang, X | 2 |
| Bailey, SL; Faut-Callahan, M; Graves, J; Paice, JA; Pellegrini, JE; Shott, S | 1 |
| Lutz, EA; Shannon, HE | 1 |
| Lechan, RM; Lee, A; Legradi, G; Nillni, EA | 1 |
| Barrot, M; Duman, RS; Gilden, L; Impey, S; Nestler, EJ; Shaw-Lutchman, TZ; Storm, D; Wallace, T; Zachariou, V | 1 |
| Cancela, LM; del Rosario Capriles, N | 1 |
| Fiore, P; Gannon, RL; Tierno, A | 1 |
| Bowen, CA; Fischer, BD; Mello, NK; Negus, SS | 1 |
| Gaspani, L; Limiroli, E; Panerai, AE; Sacerdote, P | 1 |
| Brewer, C | 1 |
| Imai, S; Itou, Y; Narita, M; Suzuki, T; Yajima, Y | 1 |
| Bardo, MT; Gehrke, BJ; Phillips, SB; Rauhut, AS | 1 |
| Cancela, LM; del Rosario, CN; Pacchioni, AM | 1 |
| Bastia, E; Bertorelli, R; Citterio, F; Corradini, L; Forlani, A; Ongini, E | 1 |
| Chawda, RP; Mahajan, SD; Nair, MP; Schwartz, SA; Shanahan, TC | 1 |
| Eisenach, JC; Sandner-Kiesling, A | 1 |
| Jones, RM; Linsenmayer, DC; Mello, NK; Negus, SS; Portoghese, PS | 1 |
| Ho, IK; Rockhold, RW; Sinchaisuk, S | 1 |
| Sterious, SN; Walker, EA | 2 |
| David Clark, J; Demirci, H; Gharagozlou, P; Lameh, J | 1 |
| Bardo, MT; Gehrke, BJ; Rauhut, AS; Shortridge, BE | 1 |
| Coles, JA; Iaizzo, PA; Sigg, DC | 1 |
| France, CR; Gauthier, CR; Gerak, LR | 1 |
| Gross, GJ; Peart, JN | 1 |
| Borgland, SL; Christie, MJ; Connor, M; Furness, JB; Osborne, PB | 1 |
| Barrett, AC; Picker, MJ; Smith, ES | 1 |
| Kishioka, S; Ko, MC; Lee, H; Mosberg, HI; Naughton, NN; Sobczyk-Kojiro, K; Song, MS; Woods, JH | 1 |
| Aghajanian, GK; Gold, SJ; Han, MH; Herman, AE; Liu, RJ; Mumby, SM; Nestler, EJ; Ni, YG; Potts, BW; Pudiak, CM | 1 |
| Brandt, MR; Gatch, MB; Mello, NK; Negus, SS | 1 |
| France, CP; McMahon, LR; Sell, SL | 2 |
| Sacerdote, P | 1 |
| Besson, JM; Gestreau, C; Le Guen, S | 1 |
| Douglas, SD; Ho, WZ; Lai, JP; Li, Y; Pleasure, DE; Xiao, WD; Zhang, T | 1 |
| Brillet, K; Bucher, B; Lecat, S; Pattus, F; Perret, BG; Rabut, G; Wagner, R | 1 |
| Arnold-Reed, DE; Basso, MR; Hansson, RC; Holman, CD; Hulse, GK; Murray, SD; O'Neil, G | 1 |
| Honda, T; Nagase, H; Nakao, K; Okano, K; Tanaka, T; Togashi, Y; Umeuchi, H | 1 |
| Darpolar, M; Kampine, JP; Leitermann, RJ; Sun, HS; Tseng, LF; Wu, HE | 1 |
| Ko, MC; Lee, H; Naughton, NN; Woods, JH | 1 |
| Douglas, SD; Guo, CJ; Ho, WZ; Moss, J; Yuan, CS | 1 |
| Law, PY; Loh, HH; Portoghese, PS | 1 |
| Bilsky, EJ; Kieffer, BL; Lin, ET; Lowery, JJ; Raehal, KM; Sadée, W; Wang, D | 1 |
| Bennett, L; Ratka, A | 1 |
| Gebhart, GF; Hartwig, AC; Law, AS; Mathias, SI | 1 |
| Gong, ZH; Qin, BY; Yan, LD; Yao, XJ | 1 |
| Izenwasser, S; Platt, DM; Rowlett, JK; Spealman, RD | 1 |
| Carstens, E; Carstens, MI; Cuellar, JM; Moore, JA; Nojima, H; Simons, CT | 1 |
| Carrigan, KA; Elliott, JC; Lysle, DT; Nelson, CJ; Picker, MJ | 1 |
| Acheson, A; de Wit, H; Farrar, AM; Hausknecht, KA; Kieres, AK; Richards, JB | 1 |
| Fujimoto, JM; Leitermann, RJ; Sun, HS; Thompson, J; Tseng, LF; Wu, HE | 1 |
| Abdi, Kh; Amini, M; Sabzevari, O; Shafiee, A | 1 |
| Aung, HH; Mehendale, SR; Moss, J; Xie, JT; Yuan, CS | 1 |
| Cohen, E; Goodchild, CS; Nadeson, R | 1 |
| D'Anci, KE; Kanarek, RB | 1 |
| Gewirtz, JC; Hanes, SL; Harris, AC | 1 |
| Cox, ML; Welch, SP | 1 |
| Hamann, SR; Malik, H; Sloan, JW; Wala, EP | 1 |
| Ise, Y; Kishimoto, Y; Misawa, K; Narita, M; Suzuki, T; Yajima, Y | 1 |
| Greeneltch, KM; Haudenschild, CC; Keegan, AD; Shi, Y | 1 |
| Dehpour, AR; Hajrasouliha, AR; Homayoun, H; Moezi, L; Sadeghipour, H; Samini, M; Shafaroodi, H; Tavakoli, S | 1 |
| Dehghani, M; Dehpour, AR; Gaskari, SA; Homayoun, H; Honar, H; Rashidi, N; Riazi, K; Sadeghipour, H | 1 |
| Dehpour, AR; Ebrahimkhani, MR; Ghaffari, K; Honar, H; Moezi, L; Riazi, K; Savadkuhi, ST; Shafaroodi, H; Tahmasebi, MS | 1 |
| Dehpour, AR; Ebrahimkhani, MR; Homayoun, H; Honar, H; Mirazi, N; Rashidi, N; Riazi, K; Sadeghipour, H | 1 |
| Sun, YG; Yu, LC | 1 |
| Dean, RL | 1 |
| Fürst, Z; Gyarmati, Z; Timár, J | 1 |
| Brunelli, SA; Hofer, MA; Shair, HN | 1 |
| Coupar, IM; Gray, AC; White, PJ | 1 |
| Bhamidipati, CM; Bilsky, EJ; Blair, JR; Lowery, JJ; Paolino, RM; Raehal, KM; Sadée, W; Wang, D | 1 |
| Arvidsson, J; Chahl, LA; Mizutani, A | 1 |
| Bonnet, U; Overlack, M; Schürks, M | 1 |
| Guo, X; Kelschenbach, J; Liu, Y; Loh, HH; Roy, S | 1 |
| Holtzman, SG; Hwang, ML; White, DA | 1 |
| Boulet, JM; Walker, K; Whiteside, GT | 1 |
| Antonilli, L; Badiani, A; Caprioli, D; Nencini, P; Petecchia, E | 1 |
| Douglas, SD; Ho, WZ; Tan, N; Wang, X; Wang, YJ; Zhang, T | 1 |
| Cao, CM; Li, GR; Wang, GY; Wong, TM; Xiao, GS; Zhou, JJ | 1 |
| Lane, DA; Morgan, MM; Patel, PA | 1 |
| Ammon-Treiber, S; Höllt, V; Loh, H; Schröder, H; Stolze, D | 1 |
| Funada, M; Sato, M; Wada, K | 1 |
| Chang, WL; Lee, SS; Su, MJ | 1 |
| Aragon, CM; Miquel, M; Pastor, R | 1 |
| Aimi, N; Horie, S; Ishikawa, H; Matsumoto, K; Murayama, T; Ponglux, D; Takayama, H; Watanabe, K | 1 |
| Chyb, J; Epler, P; Mikolajczyk, T; Socha, M; Sokolowska-Mikolajczyk, M; Szymacha, J | 1 |
| Greeneltch, KM; Keegan, AD; Kelly-Welch, AE; Shi, Y | 1 |
| Kamei, J; Nozaki, C; Saitoh, A; Tamura, N | 1 |
| Glick, SD; Maisonneuve, IM; Panchal, V; Taraschenko, OD | 1 |
| Chen, J; Chi, ZQ; Li, M; Liu, JG; Wu, ZQ | 1 |
| Daniels, DJ; Etienne, CL; Law, PY; Lenard, NR; Portoghese, PS; Roerig, SC | 1 |
| Mannelli, P; Oropeza, V; Qian, Y; Rudoy, C; Van Bockstaele, EJ | 1 |
| Juni, A; Kest, B; Klein, G | 1 |
| Arita, H; Chiba, S; Hanaoka, K; Hayashida, M; Sekiyama, H; Shu, H | 1 |
| Xiong, W; Yu, LC | 1 |
| Barrett, AC; Lomas, LM; Negus, SS; Picker, MJ; Terner, JM | 1 |
| Iordanova, MD; McNally, GP; Westbrook, RF | 1 |
| Bakhle, YS; Duarte, ID; Ferreira-Alves, DL; França, DS; Francischi, JN; Rezende, RM; Ribeiro, MC | 1 |
| Aydin, S; Beis, R; Herekman-Demir, T; Oztürk, Y | 1 |
| Boscan, P; Farver, TB; Pypendop, BH; Snyder, JR; Van Hoogmoed, LM | 1 |
| Beheshtian, A; Dehpour, AR; Ghahremani, MH; Kiumehr, S; Payabvash, S; Sabzevari, O; Salmasi, AH; Tavangar, SM | 1 |
| Le Merrer, J; Stephens, DN | 1 |
| Jasmin, L; Narasaiah, M; Tien, D | 1 |
| Hatori, Y; Horie, S; Kitajima, M; Matsumoto, K; Misawa, K; Murayama, T; Takayama, H; Tashima, K; Wongseripipatana, S | 1 |
| Douglas, SD; Ho, WZ; Kolson, DL; O'Donnell, LA; Wan, Q; Wang, X | 1 |
| Agirregoitia, E; Carracedo, A; Casis, L; Gil, J; Irazusta, J; Ochoa, C; Subiran, N; Valdivia, A | 1 |
| Walker, EA | 1 |
| Sadee, W; Sun, X; Wang, D | 1 |
| Caliari, MV; Francischi, JN; Maltos, KL; Pacheco, CM; Queiroz, CM; Rocha, OA | 1 |
| Jhamandas, K; McNaull, B; Sutak, M; Trang, T | 1 |
| Fields, HL; Lee, BS; Taha, SA; Woolley, JD | 1 |
| Bienkowski, P; Kostowski, W; Mierzejewski, P; Stefanski, R | 1 |
| Beattie, DT; Cheruvu, M; Johnson-Rabidoux, S; Kaufman, E; Mai, N; O'Keefe, M; Peterson, C; Vickery, R | 1 |
| Baskett, JA; Kracke, GR; Lever, JR; Miller, DK; Rodvelt, KR; Will, MJ | 1 |
| Daniels, DJ; Lenard, NR; Portoghese, PS; Roerig, SC | 1 |
| Garcia, JG; Moreno-Vinasco, L; Moss, J; Sammani, S; Singleton, PA; Wanderling, SL | 1 |
| France, CP; Gerak, LR | 1 |
| Buck, DJ; Davis, RL; Saffarian, N; Stevens, CW | 1 |
| Gintzler, AR; Liu, NJ; von Gizycki, H | 1 |
| Abul-Husn, NS; Jhamandas, K; Milne, B; Sutak, M | 1 |
| Luger, P; Messerschmidt, M; Morgenroth, W; Paulmann, C; Scheins, S | 1 |
| Easterling, KW; Holtzman, SG; Michaels, CC | 1 |
| Andoh, T; Kuraishi, Y; Nakashima, Y; Sasaki, A; Shiraki, K; Takasaki, I | 1 |
| Alloui, A; Baron, A; Blondeau, N; Cupo, A; Diochot, S; Eschalier, A; Escoubas, P; Gélot, A; Heurteaux, C; Lazdunski, M; Mazzuca, M; Voilley, N; Zimmer, A; Zimmer, AM | 1 |
| Honda, T; Katsura, M; Ohkuma, S; Shibasaki, M; Sumimoto, A; Torigoe, F; Tsujimura, A | 1 |
| Ho, WZ; Li, Y; Luo, GX; Peng, JS; Wan, Q; Wang, CQ; Ye, L; Zhang, T | 1 |
| Kumar, P; Sirohi, S; Yoburn, BC | 1 |
| Hamabe, W; Mashida, E; Nagae, R; Tokuyama, S | 1 |
| Ahn, DK; Han, SR; Jeon, HJ; Ju, JS; Kim, SK; Lee, MK; Lim, KH; Yang, GY; Yoon, YW | 1 |
| France, CP; Li, JX; McMahon, LR | 1 |
| Benturquia, N; Bilkei-Gorzo, A; Noble, F; Roques, BP; Zimmer, A | 1 |
| Miranda, HF; Pinardi, G; Prieto, JC; Puig, MM | 1 |
| Loscalzo, LM; Marder, M; Paladini, AC; Wasowski, C | 1 |
| Bonney, I; Carr, DB; Klinowiecka, A; Kosson, D; Kosson, P; Lipkowski, AW; Mayzner-Zawadzka, E | 1 |
| Chen, Z; Li, T; Zhang, B | 1 |
| Dehpour, AR; Doratotaj, B; Gholipour, T; Honar, H; Jannati, A; Nik, HH; Noorian, AR; Riazi, K; Shariftabrizi, A | 1 |
| Garcia, MM; Guo, N; Harlan, RE; Taylor, BK; Zadina, JE | 1 |
| Divin, MF; Holden Ko, MC; Traynor, JR | 1 |
| An, K; Arita, H; Chiba, S; Hanaoka, K; Hayashida, M; Huang, W; Shu, H | 1 |
| Ito, S; Mori, T; Sawaguchi, T | 1 |
| Arastu, MF; Dean, RL; Deaver, DR; Dong, N; Gastfriend, DR; Kriksciukaite, K; O'Driscoll, K; Reitano, K; Todtenkopf, MS | 1 |
| Asehnoune, K; Beloeil, H; Benhamou, D; Bonnet, MP; Mazoit, JX | 1 |
| Juni, A; Kest, B; Klein, G; Kowalczyk, B; Ragnauth, A | 1 |
| Ahtee, L; Korpi, ER; Piltonen, M; Tuominen, RK; Vihavainen, T | 1 |
| Becker, GL; France, CP; Gerak, LR; Li, JX; McMahon, LR | 1 |
| Huang, FS; Tang, JS; Wang, JY; Yuan, YK; Zhao, M | 1 |
| Bidlack, JM; Fulton, BS; Mathews, JL; Negus, SS; Neumeyer, JL | 1 |
| Ho, WZ; Song, L; Wan, Q; Wang, SH; Wang, X; Wang, YJ | 1 |
| Balboni, G; Jinsmaa, Y; Lazarus, LH; Marczak, ED; Salvadori, S | 1 |
| Akil, H; Capriles, N; Cecchi, M; Watson, SJ | 1 |
| Chefer, VI; Shippenberg, TS | 1 |
| Caliari, MV; Duarte, ID; Francischi, JN; Maltos, KL; Pacheco, CM; Pacheco, DF; Queiroz-Junior, CM | 1 |
| Ahn, S; Avila, LZ; Bernasconi, R; Gianolio, DA; Jarrett, PK; Liu, H; Miller, RJ; Philbrook, M; Plate, L; Santos, MR; Sun, W; Young, LE | 1 |
| Becker, GL; France, CP; Gerak, LR; Koek, W | 1 |
| Baraban, JM; Crombag, HS; Dinenna, ML; Guo, N; Holland, PC; Huganir, RL; Reti, IM; Sutton, JM; Takamiya, K | 1 |
| Abrahao, KP; Quadros, IM; Souza-Formigoni, ML | 1 |
| Dahan, A; Mousavi Gourabi, B; Teppema, LJ; van Dorp, E; van Kleef, JW | 1 |
| Beck, P; Bonacorso, HG; Drewes, C; Ferreira, J; Machado, P; Martins, MA; Mello, CF; Milano, J; Oliveira, SM; Rossato, MF; Rubin, MA; Zanatta, N | 1 |
| Steidl, S; Yeomans, JS | 1 |
| Natorska, J; Plytycz, B | 1 |
| Cornélio, AM; Nunes-de-Souza, RL | 1 |
| Dehpour, AR; Ghahremani, MH; Ghasemi, M; Rafiei-Tabatabaei, N; Riazi, K; Roshanpour, M | 1 |
| Lavine, G | 1 |
| Arakawa, H; Bekkedal, MY; Deak, T; Panksepp, J | 1 |
| Brocardo, PS; Budni, J; Lobato, KR; Rodrigues, AL; Santos, AR | 1 |
| Bakhle, YS; de Francischi, JN; Dos Reis, WG; Duarte, ID; Lima, PP; Rezende, RM | 1 |
| Bradbury, FA; Carroll, FI; Divin, MF; Traynor, JR | 1 |
| Chiba, S; Hayashida, M; Nishiyama, T; Shu, H; Yamada, Y; Yoshikawa, M | 1 |
| Scavone, JL; Van Bockstaele, EJ | 1 |
| Matulonis, JE; Pan, YX; Pasternak, GW; Rossi, GC; Xu, J; Xu, M | 1 |
| Akiyama, T; Carstens, E; Carstens, MI; Merrill, AW; Zanotto, K | 1 |
| Connor, M | 1 |
| Philibin, SD; Porter, JH; Vann, RE; Varvel, SA; Walentiny, DM; Wise, LE | 1 |
| Fuchs, PN; Uhelski, ML | 1 |
| Avila, MA; Brandão, ML; Castilho, VM; De Ross, J; Nobre, MJ; Ruggiero, RN | 1 |
| Acquas, E; Ibba, F; Kasture, S; Lecca, D; Marongiu, M; Murali, B; Pisanu, A; Puddu, A; Vinci, S; Zernig, G | 1 |
| Frishtick, R; Pick, CG; Rubovitch, V; Schreiber, S; Volis, I; Weizman, R | 1 |
| Miranda, HF; Pinardi, G | 1 |
| Choi, SM; Jung, JS; Kwon, MS; Lee, JK; Park, SH; Seo, YJ; Sim, YB; Suh, HW | 1 |
| Dehpour, AR; Ghazi, P; Hantoushzadeh, S; Javadi-Paydar, M; Lesani, A; Norouzi, A; Tavangar, SM; Vakilipour, R | 1 |
| Al-Khrasani, M; Asim, MF; Friedmann, T; Furst, S; Király, KP; Riba, P; Schmidhammer, H; Sobor, M; Spetea, M | 1 |
| Baud, FJ; Chevillard, L; Mégarbane, B; Risède, P | 1 |
| Gross, ER; Gross, GJ; Hsu, AK | 1 |
| Johnson, F; Romach, M; Sellers, E; Setnik, B; Sokolowska, M; Stauffer, J | 1 |
| Johnson, F; Katz, N; Stauffer, J; Sun, S | 1 |
| Calò, G; Guerrini, R; Hu, E; Ko, MC | 1 |
| Arout, C; Cai, M; Dahan, A; Hruby, VJ; Juni, A; Kest, B; Klein, G; Mogil, JS; Stankova, M; Waxman, AR | 1 |
| Barrot, M; Bohren, Y; Freund-Mercier, MJ; Gavériaux-Ruff, C; Karavelic, D; Kieffer, BL; Tessier, LH; Yalcin, I | 1 |
| Cheng, K; Morrissey, EM; Negus, SS; Rice, KC; Rosenberg, M | 1 |
| Bilsky, EJ; Giuvelis, D; Lowery, JJ; Osborn, MD; Skorput, AG | 1 |
| Hoffman, RS; Jang, DH; Nelson, LS; Rohe, JC | 1 |
| Komatsu, H; Mizoguchi, H; Ohkawara, Y; Ohno, I; Okuyama, K; Sakurada, S; Sora, I; Takayanagi, M; Tamura, G; Wada, K | 1 |
| Agostini, S; Broccardo, M; Bueno, L; Cartier, C; Eutamene, H; Ferrier, L; Houdeau, E; Improta, G; Petrella, C; Theodorou, V | 1 |
| Ploner, F; Theisen, MM; Van Aken, HK; Weber, TP | 1 |
| Cahill, CM; Mattioli, TA; Milne, B | 1 |
| Duggan, ST; Scott, LJ | 1 |
| Belavic, JM | 1 |
| Fujii, H; Imaide, S; Mochizuki, H; Nagase, H; Nakajima, M; Nakao, K; Nemoto, T; Tomatsu, M | 1 |
| Billa, SK; Morón, JA; Xia, Y | 1 |
| Bieberdorf, FA; Johnson, FK; Stark, JG; Stauffer, J | 1 |
| Hale, M; Katz, N; Morris, D; Stauffer, J | 1 |
| Akiyama, T; Carstens, E; Carstens, MI | 2 |
| Pergolizzi, JV; Raffa, RB | 1 |
| Cleary, DR; Fyfe, LW; Ingram, SL; Macey, TA; Morgan, MM | 1 |
| Cui, Y; Jing, J; Liu, XG; Xin, WJ; Zhang, XQ | 1 |
| Boudriau, S; Ciric, S; Johnson, FK; Kisicki, JC; Stauffer, J | 1 |
| Boudriau, S; Ciric, S; Johnson, F; Stauffer, J; Swearingen, D | 1 |
| Salari, AA; Solati, J; Zarrindast, MR | 1 |
| Brewer, R; Johnson, FK; Morris, D; Sekora, D; Stauffer, J; Wang, C; Webster, LR | 1 |
| Ahmadi, O; Dehpour, A; Farahmand, S; Khashayar, P | 1 |
| Akhoundi, MS; Alaeddini, M; Dehpour, AR; Kharazifard, MJ; Noroozi, H; Rashidpour, M | 1 |
| Kim, JH; Kim, JI; Kim, TW; Kim, WY; Lee, YS; Min, TJ; Noh, KH; Park, YC | 1 |
| Baradaran, N; Dehpour, AR; Dehpour, S; Kabiri, T; Moezi, L; Shafaroodi, H | 1 |
| Climent, L; Horga, A; Horga, JF; Peiró, AM; Zapater, P | 1 |
| Ruan, X | 1 |
| Smith, HS | 1 |
| Beninger, RJ; Olmstead, MC; Paquette, JJ; Tuerke, KJ | 1 |
| Boudriau, S; Ciric, S; Johnson, FK; Kisicki, J; Stauffer, J | 1 |
| Bihel, F; Bockel, F; Bourguignon, JJ; Elhabazi, K; Maldonado, R; Meziane, H; Mollereau, C; Moulédous, L; Petit-demoulière, B; Schmitt, M; Simonin, F; Trigo, JM; Zajac, JM | 1 |
| Li, M; McMillan, DE; Wessinger, WD | 1 |
| Beresewicz, M; Kawalec, M; Kowalczyk, JE; Lipkowski, AW; Zablocka, B | 1 |
| Kemppainen, H; Kiianmaa, K; Raivio, N; Suo-Yrjo, V | 1 |
| Ciric, S; Johnson, FK; Setnik, B; Stauffer, J; Webster, LR | 1 |
| Brewer, R; Cleveland, JM; Morris, D; Setnik, B; Webster, LR | 1 |
| Fish, EW; Heilig, M; Krouse, MC; Malanga, CJ; Robinson, JE; Thorsell, A | 1 |
| Gardner, AI; Hennessy, B; Sadleir, PH | 1 |
| Bührer, C; Garten, L | 1 |
| Diatchenko, L; Ding, F; Dokholyan, NV; Gauthier, J; Gibson, DG; Maixner, W; Serohijos, AW; Yin, S | 1 |
| Goyal, R; Kumar, K; Mohan, A; Mudgal, A; Pasha, S | 1 |
| Bath, B; Bilsky, E; Burkart, J; Dallaire, B; Magiera, D; Phelps, M; Sadee, W; Webster, L; Yancey-Wrona, J; Yang, X | 1 |
| Adler, MW; Benamar, K; Brailoiu, E; Brailoiu, GC; Deliu, E; Dun, NJ; Hooper, R; Undieh, AS | 1 |
| Castelli, M; Franchi, S; Lattuada, D; Moretti, S; Panerai, AE; Sacerdote, P; Scavullo, C | 1 |
| Carstens, E; Carstens, MI; Davoodi, A; Spradley, JM | 1 |
| Blair, HT; Halladay, LR | 1 |
| Friedman, TC; Hamid, A; Kieffer, B; Lutfy, K; Marquez, P; Nguyen, AT | 1 |
| Chen, Q; Lv, SY; Qin, YJ; Wang, NB; Yang, YJ | 1 |
| Bobeck, EN; Haseman, RA; Hong, D; Ingram, SL; Morgan, MM | 1 |
| Heintz, J; Kissling, KT; Mohassel, LR | 1 |
| Dewey, WL; Gerk, PM; He, H; Kozak, P; Li, G; Mitra, P; Scoggins, KL; Selley, DE; Stevens, DL; Yuan, Y; Zhang, Y | 1 |
| Casais e Silva, LL; Leite dos Santos, GG; Pereira Soares, MB; Villarreal, CF | 1 |
| Altarifi, AA; Miller, LL; Negus, SS | 1 |
| Bannwarth, B | 1 |
| Arttamangkul, S; Cleary, DR; Heinricher, MM; Hough, LB; Nalwalk, JW; Phillips, RS | 1 |
| Arout, C; Beijnen, JH; Dahan, A; den Hartigh, J; Kest, B; Mooren, RA; Swartjes, M; van de Wetering, K; Waxman, AR | 1 |
| Johanek, LM; King, EW; Sato, KL; Sluka, KA | 1 |
| Schaeffer, T | 1 |
| Pappagallo, M; Sokolowska, M | 1 |
| Bagetta, G; Katsuyama, S; Komatsu, T; Kuwahata, H; Mizoguchi, H; Nagaoka, K; Nakamura, H; Sakurada, S; Sakurada, T | 1 |
| Chung, NN; Gibula-Bruzda, E; Izdebski, J; Kotlinska, JH; Schiller, PW; Witkowska, E | 1 |
| Bailey, CP; Cordery, SF; Delgado-Charro, MB; Guy, RH; Husbands, SM; Ridzwan, IE; Taverner, A | 1 |
| Dunlop, SA; Farid, WO; Hulse, GK; Krstew, EV; Lawrence, AJ; Tait, RJ | 1 |
| Anselmi, L; Huynh, J; Sternini, C; Vegezzi, G | 1 |
| Arttamangkul, S; Birdsong, WT; Cheng, K; Clark, MJ; Rice, KC; Traynor, JR; Williams, JT | 1 |
| Ingram, SL; Lamberts, JT; Li, MH; Neubig, RR; Smith, CE; Traynor, JR | 1 |
| Ise, Y; Katayama, S; Mori, T; Nagase, H; Suzuki, T | 1 |
| Discala, JF; Gruber, RB; Lewis, SJ; May, WJ; McLaughlin, D; Palmer, LA; Young, AP | 1 |
| Gonzales, RA; Howard, EC; Job, MO; Mangieri, RA; Schier, CJ; Valenta, JP | 1 |
| Armstrong, SR; Beattie, DT; Campbell, CB; Hegde, SS; Long, DD; Richardson, CL; Tsuruda, PR; Vickery, RG | 1 |
| Akbarian, R; Moezi, L; Niknahad, H; Shafaroodi, H | 1 |
| Nelson, DE; Nickles, A; Su, X | 1 |
| Bezawada, P; Coop, A; Healy, JR; Jones, JW; Kane, MA; MacKerell, AD; Matsumoto, RR; Shim, J | 1 |
| Goli, V; Han, L; Setnik, B; Sommerville, K; Webster, L | 1 |
| Anghel, A; Ferrini, MG; Friedman, TC; Liu, Y; Lutfy, K; Nie, Y; Nillni, EA; Paez Espinosa, EV; Stuart, RC | 1 |
| Banks, ML; Bowers, MS; Carlezon, WA; Cheng, K; Leitl, MD; Negus, SS; Onvani, S; Rice, KC | 1 |
| Bergeron, A; Dicaire, C; Furtado, M; Garofolo, F; Mess, JN | 1 |
| Eastwood, EC; Phillips, TJ | 1 |
| Pergolizzi, JV; Raffa, RB; Taylor, R | 1 |
| Hamzah, AS; Kek, TL; Mansor, NS; Mohammat, MF; Salleh, MZ; Sani, MH; Shaameri, Z; Zakaria, ZA | 1 |
| Chelnokova, O; Eikemo, M; Laeng, B; Leknes, S; Løseth, G; Maurud, H; Riegels, J; Willoch, F | 1 |
| Awad, MM; Chakravorty, A; Cheung, JK; Choo, JM; Hiscox, TJ; Lyras, D; Rood, JI | 1 |
| Amini, A; Asadi, S; Farbood, A; Zand, F | 1 |
| Arout, CA; Caldwell, M; Kest, B; McCloskey, DP | 1 |
| Dehpour, AR; Ejtemaei Mehr, S; Haj-Mirzaian, A; Kordjazy, N; Ostadhadi, S | 1 |
| Cahill, CM; Olmstead, MC; Ong, EW; Xue, L | 1 |
| Gao, MJ; Kao, JH; Law, PY; Loh, HH; Tao, PL; Yang, PP | 1 |
| Coalson, DW; Wroblewski, K; Zacny, JP | 1 |
| Bergman, J; Kangas, BD | 1 |
| Bullmore, ET; Felici, A; Henderson, G; Kelly, E; Maltby, K; Mundell, SJ; Nathan, PJ; Roth, AL; Sava, A | 1 |
| Jagla, C; Martus, P; Stein, C | 1 |
| Clark, JD; Liang, DY; Sahbaie, P; Shi, XY; Sun, Y | 1 |
| Carlezon, WA; Cheng, K; Leitl, MD; Negus, SS; Potter, DN; Rice, KC | 1 |
| Chen, L; Li, YQ; Mei, XP; Wang, K; Wang, W; Yang, T; Zhang, FX; Zhu, C | 1 |
| Carvalho, B; Nathan, E; Ng, L; Paech, M; Sia, A; Sng, B | 1 |
| Kelsey, JE; Schierberl, KC; Verhaak, AM | 1 |
| Bell, RL; Gonzales, CR; Hart, JC; Lowe, SL; McKinzie, DL; McKinzie, JH; Mitch, CH; Need, AB; Rorick-Kehn, LM; Statnick, MA; Stoltz, RR; Suico, JG; Tauscher-Wisniewski, S; Weller, MA; Witcher, JW; Wong, CJ | 1 |
| Beaudry, H; Gendron, L; Morón, JA | 1 |
| Indovina, P; Raffaeli, W | 1 |
| Gibula-Bruzda, E; Izdebski, J; Kotlinska, JH; Marszalek-Grabska, M; Witkowska, E | 1 |
| Ghanbari, A; Mahmoodi, M; Moradi, M; Raoofi, A | 1 |
| Brokjaer, A; Christrup, LL; Dahan, A; Drewes, AM; Olesen, AE | 1 |
| Dou, Y; Huang, W; Li, Q; Lin, Y; Shu, H; Wang, Z; Xiao, X; Ye, F | 1 |
| Fernández-Guasti, A; González-Trujano, ME; Hernandez-Leon, A | 1 |
| King, T; Navratilova, E; Okun, A; Porreca, F; Remeniuk, B; Sukhtankar, D; Xie, JY | 1 |
| Arout, CA; Caldwell, M; Kest, B; Rossi, G | 1 |
| Grace, PM; Jacobson, AE; Rice, KC; Selfridge, BR; Wang, X; Watkins, LR; Yin, H; Zhang, Y | 1 |
| Lu, Z; Majumdar, S; Pan, YX; Pasternak, GW; Rossi, GC; Xu, J | 1 |
| Farré-Albaladejo, M; Fernández-Nieva, Z; Gascón-Crespí, I; Hernández, RM; Igartua, M; Moreno-Vicente, R; Navarro, A; Pedraz, JL | 1 |
| Hang, A; Liu, JG; Liu, Y; Shu, XH; Wang, Q; Wang, YJ; Zan, GY | 1 |
| Goumon, Y; Khabbazi, S; Parat, MO | 1 |
| Dolgin, E | 1 |
| Alijanpour, S; Amini-Khoei, H; Amiri, S; Dehpour, AR; Gooshe, M; Haj-Mirzaian, A; Hassanipour, M; Mehr, SE; Rahimi-Balaei, M; Shirzadian, A | 1 |
| Pixton, GC; Setnik, B; Webster, LR | 1 |
| Akatsu, R; Horie, S; Kato, S; Matsumoto, K; Mori, T; Saito, S; Shibasaki, M; Suzuki, T; Tashima, K; Umemoto, H | 1 |
| Barzin, J; Jafari-Nodoushan, M; Mobedi, H | 1 |
| de Carvalho, CR; Takahashi, RN | 1 |
| Fakhrzad, A; Khosravani, E; Moezi, L; Shafaroodi, H | 1 |
| Fernández, SN; Fernández-Llamazares, C; González, R; López, J; López-Herce, J; Santiago, MJ; Urbano, J | 1 |
| Grinnell, SG; Le Rouzic, V; Lu, Z; Majumdar, S; Marrone, GF; Pan, YX; Pasternak, GW; Rossi, GC; Xu, J | 1 |
| Ling, Y; Oberdick, J; Phelps, MA; Sadee, W; Schilling, K; Yudovich, MS | 1 |
| Aminian, A; Asadi Amoli, F; Dehpour, AR; Ejtemaei Mehr, S; Javadi, S; Moghaddas, P; Rahimian, R | 1 |
| Dai, Q; Liu, FY; Liu, WW; Wang, JL; Wei, J; Yang, B; Zeng, P; Zhang, MM | 1 |
| Bardo, MT; Beckmann, JS; Hofford, RS | 1 |
| Ayala, M; Ellis, A; Falci, S; Favret, J; Grace, PM; Hutchinson, MR; Maier, SF; Rice, KC; Skarda, B; Springer, K; Watkins, LR; Wieseler, J | 1 |
| Dehpour, AR; Haj-Mirzaian, A; Khaloo, P; Norouzi-Javidan, A; Ostadhadi, S; Sadeghi, B; Zolfagharie, S | 1 |
| Chelnokova, O; Eikemo, M; Laeng, B; Leknes, S; Løseth, G; Willoch, F | 1 |
| Eikemo, M; Gjerstad, J; Johnstone, T; Leknes, S; Løseth, GE; Willoch, F | 1 |
| Aceves, AR; Aceves, M; Bancroft, EA; Hook, MA | 1 |
| Chehrei, S; Falahi, M; Ghanbari, A; Ghiabi, HR; Kaviani, S; Moradi, M | 1 |
| Barres, BA; Bohlen, CJ; Clark, JD; Corder, G; Dickinson, JR; Low, SA; Scherrer, G; Sotoudeh, C; Sypek, EI; Tawfik, VL; Wang, D | 1 |
| Biele, G; Eikemo, M; Leknes, S; Thomsen, L; Willoch, F | 1 |
| Al-Khrasani, M; Balogh, M; Benyhe, S; Erdei, AI; Fehér, Á; Fürst, S; Hosztafi, S; Király, K; Kocsis, D; Lackó, E; Noszál, B; Riba, P; Váradi, A; Zádor, F; Zádori, ZS | 1 |
| da Luz, SC; Nogueira, CW; Pesarico, AP; Rosa, SG; Tagliapietra, CF | 1 |
| Banks, ML; Cheng, K; Moerke, MJ; Negus, SS; Rice, KC | 1 |
| Bach-Rojecky, L; Drinovac Vlah, V; Filipović, B; Lacković, Z | 1 |
| Anant, K; Sader, S; Wu, C | 1 |
| De Felice, M; Dodick, DW; Hernandez, PI; Nation, KM; Navratilova, E; Neugebauer, V; Porreca, F | 1 |
| Chen, C; Johnson, T; Meng, J; Roy, S; Wang, F; Zhang, L | 1 |
| Negus, SS; Sakloth, F | 1 |
| Cutler, SJ; Hemby, SE; Leon, F; McCurdy, CR; McIntosh, S | 1 |
| Akbarali, HI; Dewey, WL; Komla, E; Obeng, S; Selley, DE; Stevens, DL; Wang, H; Zhang, Y; Zheng, Y | 1 |
| Kreek, MJ; Reed, B; Windisch, KA | 1 |
| Deaver, DR; Kallman, MJ; Modlin, DL; Sgro, MP; Todtenkopf, MS | 1 |
| Chai, JR; Dong, H; Huang, X; Liu, GY; Long, JD; Ma, Y; Wang, YH; Wang, YJ; Xiao, ZC; Xu, XJ; Ye, RF; Zan, GY | 1 |
| An, J; Chen, C; Li, X; Lu, H; Tan, R; Wang, F; Wang, J; Wu, G; Zhao, X | 1 |
| Pixton, GC; Setnik, B; Sommerville, KW; Webster, L | 1 |
| Fanelli, A; Ghisi, D; Sorella, MC | 1 |
| Giancola, JB; Keighron, JD; Lin, SC; Newman, AH; Scaglione, A; Tanda, G; Zanettini, C | 1 |
| Banks, ML; Blough, BE; Faunce, KE; Grim, TW; Negus, SS; Obeng, S; Rice, KC; Schwienteck, KL; Zhang, Y | 1 |
| Cattaneo, M; Cicero, TJ; Dart, RC; Mardekian, J; Mendoza, M; Park, PW; Polson, M; Roland, CL; Schnoll, SH; Webster, LR | 1 |
| Heller, NM; Maher, DP; Walia, D | 1 |
| Ashfaq, UA; Farhan, A; Humayun, F; Masoud, MS; Munir, A; Qasim, M; Rehman, M; Shah, M; Tariq, I | 1 |
| Eikemo, M; Leknes, S; Løseth, GE | 1 |
| Akbarabadi, A; Niknamfar, S; Nouri Zadeh-Tehrani, S; Rahimi-Movaghar, A; Sadat-Shirazi, MS; Zarrindast, MR | 1 |
| Ishikawa, H; Sato, J; Shino, M; Suzuki, T; Tanaka, R | 1 |
| Chen, ZF; Ginosar, Y; Hincker, A; Liu, XY; Yazdi, J | 1 |
| Jilma, B; Schoergenhofer, C | 1 |
| Angiolillo, DJ; Bass, TA; Been, L; Faz, G; Franchi, F; Hu, J; Kureti, M; Park, Y; Pineda, AM; Rivas Rios, J; Rollini, F; Soffer, D; Suryadevara, S; Yaranov, D; Zenni, MM | 1 |
| Banks, ML; Blake, S; Bremer, PT; Negus, SS; Poklis, JL; Schwienteck, KL; Townsend, EA | 1 |
| Bardo, MT; Beckmann, JS; Hammerslag, LR; Hofford, RS; Kang, Q; Kryscio, RJ | 1 |
| Han, C; He, L; Lei, D; Li, S; Liu, L; Ma, T; Wen, S; Xie, S; Zhou, H | 1 |
| Kunzler, NM; Nelson, LS; Wightman, RS | 1 |
| Blasio, A; Cottone, P; DiLeo, A; Sabino, V; Valenza, M | 1 |
| Ahlström, FHG; Blomqvist, KJ; Dudek, KA; Kalso, EA; Laitila, J; Lilius, TO; Mätlik, K; Rauhala, PV; Viisanen, H | 1 |
| Annibale, P; Bock, A; Grushevskyi, EO; Heilemann, M; Isbilir, A; Karathanasis, C; Lohse, MJ; Möller, J; Osberg, B; Schütte, C; Sungkaworn, T; Sunkara, V | 1 |
| Cunningham, CW; France, CP; Gerak, LR; Hu, Z; Mada, S; Maguire, DR; Minervini, V; Soyer, A | 1 |
| Bäckström, P; Kiianmaa, K; Oinio, V; Piepponen, P; Raasmaja, A; Sundström, M; Uhari-Väänänen, J | 1 |
| Akbarali, HI; Beardsley, PM; Komla, E; Moisa, LT; Mustafa, MA; Poklis, JL; Walentiny, DM | 1 |
| Jin, Z; Kim, K; Zhan, CG; Zhang, CH; Zheng, F | 1 |
| Bilbrey, JA; Felix, JS; McCurdy, CR; McMahon, LR; Wilkerson, JL | 1 |
| Ballet, S; Bermudez, M; De Neve, J; Dumitrascuta, M; Spetea, M; Trovato, O; Wolber, G | 1 |
| Asadi Rad, A; Dadfar, B; Rahimi, S; Rashid Shabkahi, A; Siahposht-Khachaki, A; Tavakolian, G | 1 |
| Douros, A; Farhat, I; Lim, J; Panagiotoglou, D | 1 |
| Daunert, S; Deo, S; Dikici, E; Peyravian, N; Sun, E; Toborek, M | 1 |
| McKew, JC; Sadee, W | 1 |
| Bergman, J; Chambers, DR; Goldberg, A; Imler, GH; Jacobson, AE; Luo, D; Nassehi, N; Paronis, CA; Prisinzano, TE; Rice, KC; Selley, DE; Shi, L; Sulima, A; Xie, B | 1 |
| Ding, H; Kiguchi, N; Kishioka, S; Ko, MC; Mabry, KM | 1 |
| Benéitez García, MC; Colmena Crespo, I; Díez-Orejas, RM; Gil-Alegre, ME; Girón Moreno, R; Goicoechea García, C; Martín Fontelles, MI; Sánchez-Robles, EM | 1 |
| Arai, K; Ide, S; Ikeda, K; Iwase, N; Kojima, M; Taniko, K; Ushiyama, S | 1 |
| Bassman, JR; Beardsley, PM; Hassanien, SH; Holt, MC; Iula, DM; Layle, NK; Stevens, DL; Varshneya, NB | 1 |
| Chambers, DR; Jacobson, AE; Luo, D; Prisinzano, TE; Rice, KC; Sulima, A | 1 |
| Chan, MH; Chen, HH; Chen, LC | 1 |
28 review(s) available for naltrexone and morphine
| Article | Year |
|---|---|
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic | 2000 |
UDP-glucuronosyltransferases and clinical drug-drug interactions.
Topics: Clinical Trials as Topic; Drug Interactions; Enzyme Activation; Enzyme Induction; Glucuronides; Glucuronosyltransferase; Humans; Pharmaceutical Preparations; Pharmacogenetics; Polymorphism, Genetic | 2005 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Drug discrimination studies.
Topics: Analgesics, Opioid; Animals; Columbidae; Discrimination, Psychological; Dose-Response Relationship, Drug; Fentanyl; Generalization, Stimulus; Macaca mulatta; Morphine; Nalorphine; Naloxone; Naltrexone; Pentazocine; Phenazocine; Phencyclidine; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1985 |
Multiple endogenous opiate and non-opiate analgesia systems: evidence of their existence and clinical implications.
Topics: Acupuncture Therapy; Analgesia; Animals; Cholecystokinin; Conditioning, Classical; Desipramine; Dimethyl Sulfoxide; Drug Interactions; Electroshock; Endorphins; Enkephalin, Leucine; Mecamylamine; Morphine; N-Methylscopolamine; Naloxone; Naltrexone; Norepinephrine; Proglumide; Rats; Receptors, Cell Surface; Receptors, Cholecystokinin; Scopolamine; Scopolamine Derivatives; Serotonin; Spinal Cord | 1986 |
Stressor controllability and stress-induced analgesia.
Topics: Analgesia; Animals; Avoidance Learning; Electroshock; Injections, Spinal; Morphine; Naloxone; Naltrexone; Pain; Rats; Restraint, Physical; Sensory Thresholds; Stress, Physiological; Time Factors | 1986 |
Clonidine treatment of the opiate withdrawal syndrome. A review of clinical trials of a theory.
Topics: Adrenergic Fibers; Animals; Antidepressive Agents, Tricyclic; Brain; Clinical Trials as Topic; Clonidine; Dextropropoxyphene; Drug Therapy, Combination; Heroin Dependence; Humans; Locus Coeruleus; Methadone; Morphine; Naltrexone; Narcotics; Norepinephrine; Rats; Substance Withdrawal Syndrome | 1986 |
The physiology of opiate hedonic effects and the role of opioids in motivated behavior.
Topics: Animals; Conditioning, Operant; Electric Stimulation; Electroshock; Emotions; Endorphins; Feeding Behavior; Humans; Hypothalamus; Medial Forebrain Bundle; Morphine; Motivation; Naloxone; Naltrexone; Narcotics; Rats; Reward; Self Stimulation; Substance-Related Disorders | 1984 |
Limitations on the antagonistic actions of opioid antagonists.
Topics: Animals; Behavior, Animal; Columbidae; Conditioning, Operant; Cyclazocine; Macaca mulatta; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Saimiri | 1982 |
Brain opioids and mother-infant social motivation.
Topics: Animals; Biofeedback, Psychology; Female; Humans; Infant; Infant, Newborn; Maternal Behavior; Morphine; Mother-Child Relations; Motivation; Naltrexone; Object Attachment; Social Behavior | 1994 |
Neuropeptides and alcohol addiction in monkeys.
Topics: Alcoholism; Animals; beta-Endorphin; Ethanol; Humans; Macaca mulatta; Male; Morphine; Naltrexone; Neuropeptides; Rats; Reinforcement, Psychology; Self Administration | 1994 |
Morphine-induced modulation of immune status: evidence for opioid receptor mediation and compartment specificity.
Topics: Humans; Immunity; Morphine; Naltrexone; Receptors, Opioid | 1993 |
Opioid antagonists in the treatment of opioid-induced constipation and pruritus.
Topics: Clinical Trials as Topic; Constipation; Humans; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pruritus; Quaternary Ammonium Compounds | 2001 |
A review of the potential role of methylnaltrexone in opioid bowel dysfunction.
Topics: Analgesics, Opioid; Animals; Constipation; Dose-Response Relationship, Drug; Gastrointestinal Motility; Gastrointestinal Transit; Humans; Intestines; Morphine; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Receptors, Opioid | 2001 |
The preclinical development of Medisorb Naltrexone, a once a month long acting injection, for the treatment of alcohol dependence.
Topics: Alcoholism; Animals; Chemistry, Pharmaceutical; Delayed-Action Preparations; Drug Design; Drug Industry; Humans; Injections; Morphine; Naltrexone; Polymers; Rats; Receptors, Opioid, mu | 2005 |
A morphine/naltrexone combination (Embeda) for pain.
Topics: Analgesics, Opioid; Chronic Disease; Delayed-Action Preparations; Drug Approval; Drug Combinations; Humans; Morphine; Naltrexone; Narcotic Antagonists; Osteoarthritis; Pain; Randomized Controlled Trials as Topic; United States; United States Food and Drug Administration | 2010 |
Morphine/naltrexone.
Topics: Adult; Delayed-Action Preparations; Drug Combinations; Drug Interactions; Humans; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Pain; Receptors, Opioid, mu | 2010 |
Opioid formulations designed to resist/deter abuse.
Topics: Analgesics, Opioid; Delayed-Action Preparations; Drug Combinations; Humans; Morphine; Naltrexone; Niacin; Opioid-Related Disorders; Oxycodone; Pain; United States | 2010 |
Morphine sulfate and naltrexone hydrochloride extended release capsules for the management of chronic, moderate-to-severe pain, while reducing morphine-induced subjective effects upon tampering by crushing.
Topics: Analgesics, Opioid; Delayed-Action Preparations; Drug Combinations; Euphoria; Female; Humans; Male; Morphine; Naltrexone; Pain | 2011 |
Will abuse-deterrent formulations of opioid analgesics be successful in achieving their purpose?
Topics: Analgesics, Opioid; Chemistry, Pharmaceutical; Drug Combinations; Drug Discovery; Drug Overdose; Drug Prescriptions; Humans; Morphine; Naltrexone; Opioid-Related Disorders; Pain | 2012 |
Abuse-deterrent formulations, an evolving technology against the abuse and misuse of opioid analgesics.
Topics: Analgesics, Opioid; Buprenorphine; Chemistry, Pharmaceutical; Dextroamphetamine; Humans; Lisdexamfetamine Dimesylate; Morphine; Naltrexone; Opioid-Related Disorders; Pain; Prescription Drug Misuse; United States; United States Food and Drug Administration | 2012 |
Sequestered naltrexone in sustained release morphine or oxycodone - a way to inhibit illicit use?
Topics: Analgesics, Opioid; Delayed-Action Preparations; Humans; Illicit Drugs; Morphine; Naltrexone; Opioid-Related Disorders; Oxycodone | 2014 |
Abuse-deterrent opioid formulations.
Topics: Analgesics, Opioid; Animals; Chemistry, Pharmaceutical; Delayed-Action Preparations; Drug Combinations; Humans; Morphine; Naltrexone; Opioid-Related Disorders | 2015 |
Safety profile of extended-release morphine sulfate with sequestered naltrexone hydrochloride in older patients: pooled analysis of three clinical trials.
Topics: Aged; Analgesics, Opioid; Chemistry, Pharmaceutical; Delayed-Action Preparations; Drug Combinations; Female; Humans; Male; Middle Aged; Morphine; Naltrexone; Narcotic Antagonists; Randomized Controlled Trials as Topic | 2016 |
Morphine sulfate abuse-deterrent formulations for the treatment of chronic pain.
Topics: Abuse-Deterrent Formulations; Analgesics, Opioid; Chronic Pain; Delayed-Action Preparations; Humans; Morphine; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Prescription Drug Misuse | 2018 |
Opioid Withdrawal Precipitated by Long-Acting Antagonists.
Topics: Drug Combinations; Emergency Service, Hospital; Humans; Morphine; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Substance Withdrawal Syndrome | 2020 |
Relative effectiveness of medications for opioid-related disorders: A systematic review and network meta-analysis of randomized controlled trials.
Topics: Analgesics, Opioid; Buprenorphine; Humans; Methadone; Morphine; Naltrexone; Network Meta-Analysis; Opioid-Related Disorders; Randomized Controlled Trials as Topic | 2022 |
Ligand-Free Signaling of G-Protein-Coupled Receptors: Relevance to μ Opioid Receptors in Analgesia and Addiction.
Topics: Analgesia; Analgesics, Opioid; Humans; Ligands; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Pain; Receptors, Opioid, mu | 2022 |
42 trial(s) available for naltrexone and morphine
| Article | Year |
|---|---|
Human pharmacology and abuse potential of nalmefene.
Topics: Adult; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Male; Morphine; Naltrexone; Narcotic Antagonists; Substance-Related Disorders | 1991 |
Prophylactic oral naltrexone with epidural morphine: effect on adverse reactions and ventilatory responses to carbon dioxide.
Topics: Administration, Oral; Adult; Analgesia, Epidural; Anesthesia, Obstetrical; Carbon Dioxide; Cesarean Section; Double-Blind Method; Female; Humans; Morphine; Naltrexone; Pain, Postoperative; Pregnancy; Prospective Studies; Randomized Controlled Trials as Topic; Respiration Disorders | 1990 |
Prophylactic oral naltrexone with intrathecal morphine for cesarean section: effects on adverse reactions and analgesia.
Topics: Administration, Oral; Adult; Cesarean Section; Double-Blind Method; Female; Humans; Injections, Spinal; Morphine; Naltrexone; Nausea; Pain, Postoperative; Pregnancy; Pruritus; Randomized Controlled Trials as Topic; Sleep | 1990 |
Nontolerance to the opioid antagonism of naltrexone.
Topics: Adult; Arousal; Clinical Trials as Topic; Dose-Response Relationship, Drug; Double-Blind Method; Drug Tolerance; Euphoria; Female; Heart Rate; Heroin Dependence; Humans; Male; Middle Aged; Morphine; Naloxone; Naltrexone; Receptors, Opioid | 1985 |
Antagonism of morphine-induced respiratory depression with nalmefene.
Topics: Adult; Carbon Dioxide; Depression, Chemical; Humans; Male; Middle Aged; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Partial Pressure; Respiration; Time Factors | 1988 |
Clonidine treatment of the opiate withdrawal syndrome. A review of clinical trials of a theory.
Topics: Adrenergic Fibers; Animals; Antidepressive Agents, Tricyclic; Brain; Clinical Trials as Topic; Clonidine; Dextropropoxyphene; Drug Therapy, Combination; Heroin Dependence; Humans; Locus Coeruleus; Methadone; Morphine; Naltrexone; Narcotics; Norepinephrine; Rats; Substance Withdrawal Syndrome | 1986 |
A bioequivalence study of oral controlled-release morphine using naltrexone blockade.
Topics: Administration, Oral; Adult; Cross-Over Studies; Delayed-Action Preparations; Humans; Male; Morphine; Naltrexone; Therapeutic Equivalency | 1995 |
Efficacy of methylnaltrexone versus naloxone for reversal of morphine-induced depression of hypoxic ventilatory response.
Topics: Adult; Double-Blind Method; Humans; Hypoxia; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Respiration | 1994 |
Opioid antagonist adjuncts to epidural morphine for postcesarean analgesia: maternal outcomes.
Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Butorphanol; Cesarean Section; Female; Humans; Morphine; Nalbuphine; Naltrexone; Narcotic Antagonists; Pain, Postoperative; Pregnancy; Prospective Studies | 1993 |
Relative bioavailability of controlled-release oral morphine sulfate during naltrexone blockade.
Topics: Adult; Biological Availability; Blood Pressure; Cross-Over Studies; Delayed-Action Preparations; Half-Life; Humans; Male; Middle Aged; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Pulse; Respiration; Single-Blind Method | 1995 |
Methylnaltrexone prevents morphine-induced delay in oral-cecal transit time without affecting analgesia: a double-blind randomized placebo-controlled trial.
Topics: Adolescent; Adult; Analgesics, Opioid; Breath Tests; Cold Temperature; Double-Blind Method; Female; Gastrointestinal Transit; Humans; Hydrogen; Injections, Intravenous; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain Measurement; Pressure; Quaternary Ammonium Compounds | 1996 |
The safety and efficacy of oral methylnaltrexone in preventing morphine-induced delay in oral-cecal transit time.
Topics: Administration, Oral; Adult; Analgesics, Opioid; Breath Tests; Dose-Response Relationship, Drug; Female; Gastrointestinal Transit; Humans; Hydrogen; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Quaternary Ammonium Compounds; Reference Values; Single-Blind Method | 1997 |
Efficacy of orally administered methylnaltrexone in decreasing subjective effects after intravenous morphine.
Topics: Administration, Oral; Adult; Affect; Arousal; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Infusions, Intravenous; Male; Morphine; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Treatment Outcome | 1998 |
Effects of prophylactic nalmefene on the incidence of morphine-related side effects in patients receiving intravenous patient-controlled analgesia.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics, Opioid; Dose-Response Relationship, Drug; Female; Humans; Middle Aged; Morphine; Naltrexone; Narcotic Antagonists; Nausea; Postoperative Complications; Pruritus; Vomiting | 1999 |
Effects of enteric-coated methylnaltrexone in preventing opioid-induced delay in oral-cecal transit time.
Topics: Administration, Oral; Adult; Breath Tests; Double-Blind Method; Female; Gastrointestinal Agents; Gastrointestinal Transit; Humans; Lactulose; Male; Morphine; Naltrexone; Narcotic Antagonists; Pilot Projects; Quaternary Ammonium Compounds; Tablets, Enteric-Coated; Time Factors | 2000 |
Nalmefene: blockade of intravenous morphine challenge effects in opioid abusing humans.
Topics: Adult; Analysis of Variance; Cross-Over Studies; Double-Blind Method; Humans; Injections, Intravenous; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Pupil | 2000 |
Effects of subcutaneous methylnaltrexone on morphine-induced peripherally mediated side effects: a double-blind randomized placebo-controlled trial.
Topics: Administration, Oral; Adult; Analgesics, Opioid; Breath Tests; Double-Blind Method; Female; Gastrointestinal Transit; Humans; Injections, Intravenous; Injections, Subcutaneous; Male; Morphine; Naltrexone; Narcotic Antagonists; Peripheral Nervous System; Quaternary Ammonium Compounds | 2002 |
The impact of nalmefene on side effects due to intrathecal morphine at cesarean section.
Topics: Adult; Analgesia, Epidural; Analgesics, Opioid; Cesarean Section; Double-Blind Method; Female; Humans; Morphine; Naltrexone; Narcotic Antagonists; Pain, Postoperative; Postoperative Complications; Postoperative Nausea and Vomiting; Pregnancy; Pruritus; Statistics, Nonparametric; Survival Analysis; Time Factors | 2001 |
Pharmacokinetics of the opioid antagonist N-methylnaltrexone and evaluation of its effects on gastrointestinal tract function in horses treated or not treated with morphine.
Topics: Analgesics, Opioid; Animals; Drug Interactions; Gastrointestinal Tract; Gastrointestinal Transit; Horses; Male; Morphine; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds | 2006 |
Subjective effects and safety of whole and tampered morphine sulfate and naltrexone hydrochloride (ALO-01) extended-release capsules versus morphine solution and placebo in experienced non-dependent opioid users: a randomized, double-blind, placebo-contro
Topics: Adult; Analgesics, Opioid; Capsules; Cross-Over Studies; Delayed-Action Preparations; Double-Blind Method; Drug Combinations; Euphoria; Female; Humans; Male; Middle Aged; Morphine; Naltrexone; Narcotic Antagonists; Pharmaceutical Solutions; Pupil; Time Factors; Young Adult | 2009 |
ALO-01 (morphine sulfate and naltrexone hydrochloride) extended-release capsules in the treatment of chronic pain of osteoarthritis of the hip or knee: pharmacokinetics, efficacy, and safety.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Chronic Disease; Cross-Over Studies; Double-Blind Method; Drug Combinations; Female; Humans; Illicit Drugs; Male; Middle Aged; Morphine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Osteoarthritis, Hip; Osteoarthritis, Knee; Pain Measurement; Treatment Outcome | 2010 |
Relative oral bioavailability of morphine and naltrexone derived from crushed morphine sulfate and naltrexone hydrochloride extended-release capsules versus intact product and versus naltrexone solution: a single-dose, randomized-sequence, open-label, thr
Topics: Administration, Oral; Adult; Area Under Curve; Biological Availability; Cross-Over Studies; Delayed-Action Preparations; Drug Combinations; Female; Humans; Male; Middle Aged; Morphine; Naltrexone; Narcotic Antagonists; Narcotics | 2010 |
Morphine sulfate and naltrexone hydrochloride extended release capsules in patients with chronic osteoarthritis pain.
Topics: Acetaminophen; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Capsules; Chronic Disease; Delayed-Action Preparations; Double-Blind Method; Female; Humans; Male; Middle Aged; Morphine; Naltrexone; Narcotic Antagonists; Osteoarthritis; Pain; Pain Measurement; Placebos; Treatment Outcome | 2010 |
The relative bioavailability of morphine sulfate and naltrexone hydrochloride extended release capsules (EMBEDA®) and an extended release morphine sulfate capsule formulation (KADIAN®) in healthy adults under fasting conditions.
Topics: Adult; Analgesics, Opioid; Area Under Curve; Biological Availability; Biotransformation; Capsules; Chemistry, Pharmaceutical; Cross-Over Studies; Delayed-Action Preparations; Double-Blind Method; Drug Combinations; Fasting; Female; Half-Life; Humans; Male; Middle Aged; Morphine; Naltrexone; Therapeutic Equivalency; Young Adult | 2011 |
Food effects on the pharmacokinetics of morphine sulfate and naltrexone hydrochloride extended release capsules.
Topics: Adult; Area Under Curve; Biological Availability; Cross-Over Studies; Delayed-Action Preparations; Dietary Fats; Drug-Related Side Effects and Adverse Reactions; Fasting; Feeding Behavior; Female; Food-Drug Interactions; Humans; Male; Middle Aged; Morphine; Naltrexone | 2010 |
Long-term safety and efficacy of morphine sulfate and naltrexone hydrochloride extended release capsules, a novel formulation containing morphine and sequestered naltrexone, in patients with chronic, moderate to severe pain.
Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Chronic Disease; Constipation; Delayed-Action Preparations; Drug Combinations; Female; Humans; Male; Middle Aged; Morphine; Naltrexone; Narcotic Antagonists; Nausea; Pain; Pain Measurement; Treatment Outcome | 2010 |
Does adding low doses of oral naltrexone to morphine alter the subsequent opioid requirements and side effects in trauma patients?
Topics: Administration, Oral; Adult; Analgesia; Analgesics, Opioid; Double-Blind Method; Drug Therapy, Combination; Extremities; Female; Humans; Male; Morphine; Naltrexone; Narcotic Antagonists; Wounds and Injuries | 2012 |
Effects of alcohol on the pharmacokinetics of morphine sulfate and naltrexone hydrochloride extended release capsules.
Topics: Adult; Alcohol Drinking; Analgesics, Opioid; Analysis of Variance; Area Under Curve; Capsules; Cross-Over Studies; Delayed-Action Preparations; Drug Combinations; Drug Interactions; Ethanol; Female; Humans; Male; Metabolic Clearance Rate; Models, Biological; Morphine; Naltrexone; Narcotic Antagonists; Young Adult | 2012 |
Impact of intravenous naltrexone on intravenous morphine-induced high, drug liking, and euphoric effects in experienced, nondependent male opioid users.
Topics: Analgesics, Opioid; Cross-Over Studies; Double-Blind Method; Drug Combinations; Drug Interactions; Euphoria; Humans; Injections, Intravenous; Male; Morphine; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Pain; Pain Measurement; Substance-Related Disorders; Young Adult | 2011 |
Opioid titration and conversion in patients receiving morphine sulfate and naltrexone hydrochloride extended release capsules.
Topics: Adolescent; Adult; Aged; Capsules; Delayed-Action Preparations; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Morphine; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Young Adult | 2011 |
6β-naltrexol, a peripherally selective opioid antagonist that inhibits morphine-induced slowing of gastrointestinal transit: an exploratory study.
Topics: Adult; Animals; Breath Tests; Constipation; Cross-Over Studies; Double-Blind Method; Gastrointestinal Transit; Humans; Male; Miosis; Morphine; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Pilot Projects; Placebos; Young Adult | 2011 |
Assessment of pharmacodynamic effects following oral administration of crushed morphine sulfate and naltrexone hydrochloride extended-release capsules compared with crushed morphine sulfate controlled-release tablets and placebo in nondependent recreation
Topics: Analgesics, Opioid; Area Under Curve; Body Mass Index; Cross-Over Studies; Delayed-Action Preparations; Discrimination, Psychological; Double-Blind Method; Endpoint Determination; Ethnicity; Female; Follow-Up Studies; Humans; Male; Morphine; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Pupil; Tablets; Young Adult | 2013 |
Rewards of beauty: the opioid system mediates social motivation in humans.
Topics: Analgesics, Opioid; Beauty; Cross-Over Studies; Double-Blind Method; Face; Humans; Male; Morphine; Motivation; Naltrexone; Narcotic Antagonists; Photic Stimulation; Receptors, Opioid, mu; Reward | 2014 |
The effect of methylnaltrexone on the side effects of intrathecal morphine after orthopedic surgery under spinal anesthesia.
Topics: Adult; Analgesics, Opioid; Anesthesia, Spinal; Double-Blind Method; Female; Humans; Male; Middle Aged; Morphine; Naltrexone; Narcotic Antagonists; Orthopedic Procedures; Pain, Postoperative; Postoperative Complications; Quaternary Ammonium Compounds; Young Adult | 2015 |
Methylnaltrexone: its pharmacological effects alone and effects on morphine in healthy volunteers.
Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Double-Blind Method; Female; Healthy Volunteers; Heart Rate; Humans; Infusions, Intravenous; Male; Morphine; Naltrexone; Narcotic Antagonists; Pupil; Quaternary Ammonium Compounds; Receptors, Opioid, mu; Treatment Outcome; Young Adult | 2015 |
Peripheral opioid receptor blockade increases postoperative morphine demands--a randomized, double-blind, placebo-controlled trial.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesia, Patient-Controlled; Analgesics, Opioid; Arthroplasty, Replacement, Knee; Double-Blind Method; Female; Humans; Male; Middle Aged; Morphine; Naltrexone; Narcotic Antagonists; Pain Measurement; Pain, Postoperative; Quaternary Ammonium Compounds; Young Adult | 2014 |
Methylnaltrexone to prevent intrathecal morphine-induced pruritus after Caesarean delivery: a multicentre, randomized clinical trial.
Topics: Adult; Analgesia, Obstetrical; Analgesics, Opioid; Anesthesia, Spinal; Australia; Cesarean Section; Female; Humans; Middle Aged; Morphine; Naltrexone; Narcotic Antagonists; Postoperative Complications; Pregnancy; Pruritus; Quaternary Ammonium Compounds; Singapore; Treatment Outcome; United States; Young Adult | 2015 |
Determining pharmacological selectivity of the kappa opioid receptor antagonist LY2456302 using pupillometry as a translational biomarker in rat and human.
Topics: Adolescent; Adult; Animals; Benzamides; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Fentanyl; Humans; Male; Middle Aged; Miosis; Morphine; Mydriasis; Naltrexone; Narcotic Antagonists; Narcotics; Pupil; Pyrrolidines; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Young Adult | 2014 |
The effects of morphine and methylnaltrexone on gastrointestinal pain in healthy male participants.
Topics: Administration, Rectal; Adult; Analgesics, Opioid; Cross-Over Studies; Double-Blind Method; Healthy Volunteers; Humans; Injections, Subcutaneous; Male; Middle Aged; Morphine; Muscle, Skeletal; Naltrexone; Narcotic Antagonists; Pupil; Quaternary Ammonium Compounds; Rectum; Skin; Visceral Pain; Young Adult | 2015 |
Opioid Modulation of Value-Based Decision-Making in Healthy Humans.
Topics: Adult; Analgesics, Opioid; Computer Simulation; Cross-Over Studies; Decision Making; Double-Blind Method; Humans; Models, Neurological; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Reaction Time; Receptors, Opioid, mu; Reward; Young Adult | 2017 |
Effects of opioid receptor stimulation and blockade on touch pleasantness: a double-blind randomised trial.
Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Double-Blind Method; Emotions; Humans; Male; Morphine; Naltrexone; Narcotic Antagonists; Reward; Touch; Touch Perception; Young Adult | 2019 |
Effects of Methylnaltrexone on Ticagrelor-Induced Antiplatelet Effects in Coronary Artery Disease Patients Treated With Morphine.
Topics: Administration, Intravenous; Administration, Oral; Aged; Analgesics, Opioid; Blood Platelets; Cell Adhesion Molecules; Coronary Artery Disease; Cross-Over Studies; Double-Blind Method; Drug Interactions; Female; Florida; Gastric Emptying; Gastrointestinal Absorption; Humans; Male; Microfilament Proteins; Middle Aged; Morphine; Naltrexone; Narcotic Antagonists; Phosphoproteins; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Quaternary Ammonium Compounds; Ticagrelor; Treatment Outcome | 2019 |
1201 other study(ies) available for naltrexone and morphine
| Article | Year |
|---|---|
Quantum chemical studies of N-substituent variation in the oxymorphone series of opiate narcotics.
Topics: Analgesics, Opioid; Animals; Hydromorphone; In Vitro Techniques; Mice; Molecular Conformation; Oxymorphone; Quantum Theory; Rats; Structure-Activity Relationship; Swine; Thermodynamics | 1978 |
Structure-activity relationships for drugs binding to the agonist and antagonist states of the primary morphine receptor.
Topics: Algorithms; Animals; Kinetics; Models, Molecular; Narcotic Antagonists; Narcotics; Protein Conformation; Rats; Receptors, Opioid; Structure-Activity Relationship | 1988 |
A novel opioid receptor site directed alkylating agent with irreversible narcotic antagonistic and reversible agonistic activities.
Topics: Alkylating Agents; Animals; Guinea Pigs; In Vitro Techniques; Morphinans; Muscle Contraction; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Narcotics; Oxymorphone; Receptors, Opioid | 1980 |
Allylprodine analogues as receptor probes. Evidence that phenolic and nonphenolic ligands interact with different subsites on identical opioid receptors.
Topics: Animals; Chemical Phenomena; Chemistry, Physical; Guinea Pigs; Ileum; In Vitro Techniques; Ligands; Mice; Morphine; Muscle Contraction; Muscle, Smooth; Narcotic Antagonists; Phenols; Piperidines; Reaction Time; Receptors, Opioid; Structure-Activity Relationship | 1981 |
Different receptor sites mediate opioid agonism and antagonism.
Topics: Animals; Binding Sites; Kinetics; Naltrexone; Narcotic Antagonists; Narcotics; Receptors, Opioid; Structure-Activity Relationship | 1983 |
Some 14 beta-substituted analogues of N-(cyclopropylmethyl)normorphine.
Topics: Animals; Chemical Phenomena; Chemistry; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Morphine; Morphine Derivatives; Muscle, Smooth; Vas Deferens | 1981 |
Analgesic narcotic antagonists. 8. 7 alpha-Alkyl-4,5 alpha-epoxymorphinan-6-ones.
Topics: Analgesics; Animals; Chemical Phenomena; Chemistry; Codeine; Hydrocodone; In Vitro Techniques; Mice; Narcotic Antagonists; Rats; Reaction Time | 1981 |
Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors.
Topics: Analgesics; Animals; Binding Sites; Cell Line; CHO Cells; Cloning, Molecular; Cricetinae; Ligands; PC12 Cells; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Software | 1994 |
Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications.
Topics: Animals; Aorta, Thoracic; Cocaine; Cyclic AMP; Electric Stimulation; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Mice; Muscle, Smooth; Opioid-Related Disorders; Rats; Receptors, Dopamine; Receptors, Opioid; Receptors, Serotonin; Substance-Related Disorders | 1998 |
Predicting blood-brain barrier permeation from three-dimensional molecular structure.
Topics: Blood-Brain Barrier; Databases, Factual; Models, Chemical; Molecular Conformation; Multivariate Analysis; Permeability; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
3-Carboxamido analogues of morphine and naltrexone. synthesis and opioid receptor binding properties.
Topics: Amides; Morphine Derivatives; Naltrexone; Protein Binding; Receptors, Opioid | 2001 |
Identification of opioid ligands possessing mixed micro agonist/delta antagonist activity among pyridomorphinans derived from naloxone, oxymorphone, and hydromorphone [correction of hydropmorphone].
Topics: Analgesics; Animals; Binding Sites; Brain; Drug Tolerance; Electric Stimulation; Guinea Pigs; Hydromorphone; Ileum; In Vitro Techniques; Ligands; Male; Mice; Mice, Inbred ICR; Morphinans; Muscle Contraction; Muscle, Smooth; Naloxone; Oxymorphone; Pyridines; Radioligand Assay; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Vas Deferens | 2004 |
Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure.
Topics: Algorithms; Animals; Dogs; Haplorhini; Humans; Pharmaceutical Preparations; Pharmacokinetics; Rats; Species Specificity; Tissue Distribution | 2005 |
Structural determinants of opioid activity in derivatives of 14-aminomorphinones: effect of substitution in the aromatic ring of cinnamoylaminomorphinones and codeinones.
Topics: Cinnamates; Codeine; Drug Design; Ligands; Molecular Structure; Morphine Derivatives; Receptors, Opioid, mu; Stereoisomerism; Structure-Activity Relationship | 2006 |
Naloxone acts as a potent analgesic in transgenic mouse models of sickle cell anemia.
Topics: Analgesics; Analgesics, Opioid; Anemia, Sickle Cell; Animals; Chemokine CCL5; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Drug Synergism; Injections, Intraventricular; Injections, Spinal; Injections, Subcutaneous; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Knockout; Mice, Transgenic; Morphine; Naloxone; Pain; Pain Measurement; Receptors, CCR5 | 2007 |
Hologram QSAR model for the prediction of human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2007 |
Cinnamoyl derivatives of 7alpha-aminomethyl-6,14-endo-ethanotetrahydrothebaine and 7alpha-aminomethyl-6,14-endo-ethanotetrahydrooripavine and related opioid ligands.
Topics: Analgesics; Animals; Binding, Competitive; CHO Cells; Cinnamates; Cricetinae; Cricetulus; Humans; Ligands; Mice; Molecular Conformation; Narcotic Antagonists; Radioligand Assay; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship; Thebaine | 2007 |
The influence of esters and carboxylic acids as the N-substituent of opioids. Part 1: Benzomorphans.
Topics: Analgesics, Opioid; Benzomorphans; Carboxylic Acids; Esters; Molecular Structure; Stereoisomerism; Structure-Activity Relationship | 2008 |
Endomorphin-2 with a beta-turn backbone constraint retains the potent micro-opioid receptor agonist properties.
Topics: Magnetic Resonance Spectroscopy; Models, Molecular; Oligopeptides; Protein Structure, Secondary; Receptors, Opioid, mu; Solutions; Stereoisomerism; Structure-Activity Relationship | 2008 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Syntheses and opioid receptor binding properties of carboxamido-substituted opioids.
Topics: Amides; Analgesics, Opioid; Humans; Protein Binding; Receptors, Opioid; Structure-Activity Relationship; Tramadol | 2009 |
Design, synthesis, and biological evaluation of 6alpha- and 6beta-N-heterocyclic substituted naltrexamine derivatives as mu opioid receptor selective antagonists.
Topics: Amino Acid Sequence; Analgesics; Analgesics, Opioid; Animals; Binding Sites; Binding, Competitive; CHO Cells; Cricetinae; Cricetulus; Drug Design; Ligands; Models, Molecular; Molecular Sequence Data; Morphinans; Morphine; Naltrexone; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sequence Alignment; Structure-Activity Relationship | 2009 |
14 beta-O-cinnamoylnaltrexone and related dihydrocodeinones are mu opioid receptor partial agonists with predominant antagonist activity.
Topics: Hydrocodone; Magnetic Resonance Spectroscopy; Naltrexone; Receptors, Opioid, mu; Spectrometry, Mass, Electrospray Ionization | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Experimental solubility profiling of marketed CNS drugs, exploring solubility limit of CNS discovery candidate.
Topics: Central Nervous System Agents; Drug Evaluation, Preclinical; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Solubility | 2010 |
Generation of novel radiolabeled opiates through site-selective iodination.
Topics: Animals; Binding Sites; Binding, Competitive; CHO Cells; Cricetinae; Cricetulus; Humans; Iodine Radioisotopes; Molecular Structure; Neurotransmitter Agents; Oxymorphone; Radioligand Assay; Receptors, Opioid | 2011 |
Synthesis of novel triplet drugs with 1,3,5-trioxazatriquinane skeletons and their pharmacologies. 1: Synthesis of triplet drugs with morphinan skeletons.
Topics: Analgesics; Bridged-Ring Compounds; Dose-Response Relationship, Drug; Molecular Structure; Morphinans; Naltrexone; Receptors, Opioid, mu | 2011 |
Synthesis of new opioid derivatives with a propellane skeleton and their pharmacology: part 1.
Topics: Analgesics, Opioid; Animals; Bridged-Ring Compounds; Cells, Cultured; Mice; Molecular Structure; Protein Binding; Receptors, Opioid, kappa; Structure-Activity Relationship; Substrate Specificity | 2011 |
Synthesis of novel triplet drugs with 1,3,5-trioxazatriquinane skeletons and their pharmacologies. Part 2: Synthesis of novel triplet drugs with the epoxymethano structure (capped homotriplet).
Topics: Analgesics, Opioid; Animals; Bridged-Ring Compounds; Mice; Models, Molecular; Nitriles; Nociception; Nociceptive Pain; Pain Measurement; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sesquiterpenes; Tosyl Compounds | 2011 |
Synthesis and evaluation of aryl-naloxamide opiate analgesics targeting truncated exon 11-associated μ opioid receptor (MOR-1) splice variants.
Topics: Amides; Analgesics; Animals; Behavior, Animal; Brain; Cell Line; Chemistry Techniques, Synthetic; Exons; Male; Mice; Opiate Alkaloids; Protein Isoforms; Protein Structure, Tertiary; Receptors, Opioid, mu; Structure-Activity Relationship | 2012 |
Design, synthesis, and biological evaluation of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4'-pyridyl)carboxamido]morphinan derivatives as peripheral selective μ opioid receptor Agents.
Topics: Analgesics; Animals; Caco-2 Cells; Drug Design; Gastrointestinal Motility; Humans; Male; Mice; Models, Molecular; Molecular Structure; Morphinans; Morphine Derivatives; Narcotic Antagonists; Radioligand Assay; Receptors, Opioid, mu; Structure-Activity Relationship; Tissue Distribution | 2012 |
Design, syntheses, and pharmacological characterization of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(isoquinoline-3'-carboxamido)morphinan analogues as opioid receptor ligands.
Topics: Animals; CHO Cells; Cricetulus; Drug Design; Humans; Isoquinolines; Ligands; Mice; Molecular Dynamics Simulation; Morphinans; Morphine Dependence; Narcotic Antagonists; Receptors, Opioid, mu; Structure-Activity Relationship | 2015 |
Opioids as Substrates and Inhibitors of the Genetically Highly Variable Organic Cation Transporter OCT1.
Topics: Analgesics, Opioid; HEK293 Cells; Humans; Inhibitory Concentration 50; Models, Molecular; Organic Cation Transporter 1; Permeability; Protein Conformation | 2019 |
Behavioral effects of narcotic analgesics administered alone or in combination with narcotic antagonists.
Topics: Analgesics, Opioid; Animals; Avoidance Learning; Behavior, Animal; Drug Interactions; Electroshock; Haplorhini; Macaca fascicularis; Methadone; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Time Factors | 1976 |
Development of Chronomers for narcotic antagonists.
Topics: Animals; Biodegradation, Environmental; Drug Implants; Hydrogen-Ion Concentration; Kinetics; Morphine; Naloxone; Naltrexone; Polymers; Rats; Reaction Time | 1975 |
An improved long-acting delivery system for narcotic antagonists.
Topics: Animals; Cholesterol; Delayed-Action Preparations; Drug Implants; Male; Morphine; Naltrexone; Narcotic Antagonists; Placebos; Rats; Stearates; Time Factors | 1978 |
Opiate-receptor mediated changes in monoamine synthesis in rat brain.
Topics: Animals; Behavior, Animal; Biogenic Amines; Brain; Catalepsy; Endorphins; Humans; Injections, Intraventricular; Male; Morphine; Naloxone; Naltrexone; Rats; Receptors, Opioid; Time Factors | 1978 |
GABA turnover as a tool to explore the function of GABA-ergic synapses: physiological and pharmacological studies.
Topics: Animals; Brain; Carbon Isotopes; Electric Stimulation; gamma-Aminobutyric Acid; Homovanillic Acid; Kinetics; Morphine; Naltrexone; Neurotransmitter Agents; Rats; Substantia Nigra; Synapses; Tissue Distribution | 1979 |
Chloroxymorphamine, and opioid receptor site-directed alkylating agent having narcotic agonist activity.
Topics: Alkylating Agents; Animals; Chlorambucil; Dose-Response Relationship, Drug; Drug Synergism; Guinea Pigs; Hydromorphone; In Vitro Techniques; Morphine; Naloxone; Naltrexone; Nitrogen Mustard Compounds; Norepinephrine; Oxymorphone; Phenoxybenzamine; Receptors, Opioid | 1979 |
Morphine as a discriminative cue in gerbils: drug generalization and antagonism.
Topics: Animals; Cues; Discrimination, Psychological; Drug Antagonism; Generalization, Stimulus; Gerbillinae; Male; Morphine; Naltrexone; Stereoisomerism | 1978 |
Prevention by naltrexone of tolerance to the rate-decreasing effects of morphine on schedule-controlled responding in the pigeon.
Topics: Animals; Columbidae; Conditioning, Operant; Drug Tolerance; Male; Morphine; Naloxone; Naltrexone; Reinforcement Schedule; Time Factors | 1979 |
Naltrexone-induced hypothermia in the rat.
Topics: Animals; Body Temperature Regulation; Dose-Response Relationship, Drug; Humans; Hypothermia; Morphine; Naloxone; Naltrexone; Placebos; Rats; Receptors, Opioid; Substance Withdrawal Syndrome; Substance-Related Disorders | 1976 |
Endogenous opiate receptor ligand: electrically induced release in the guinea pig ileum.
Topics: Electric Stimulation; Ileum; Ligands; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Nerve Tissue Proteins; Neuromuscular Junction; Peptides; Receptors, Opioid; Stereoisomerism | 1977 |
On the mechanism of the decrease in cerebellar cyclic GMP content elicited by opiate receptor agonists.
Topics: Analgesics; Animals; Apomorphine; Cerebellum; Corpus Striatum; Cyclic GMP; Dextromoramide; Ethanolamines; Injections; Male; Morphine; Naltrexone; Narcotics; Pyridines; Rats; Reaction Time; Receptors, Opioid; Time Factors | 1977 |
Behavioural dissociation of the enkephalinergic systems of nucleus accumbens and nucleus caudatus.
Topics: Animals; Brain; Caudate Nucleus; Enkephalins; Globus Pallidus; Male; Morphine; Naloxone; Naltrexone; Olfactory Bulb; Oligopeptides; Rats; Receptors, Opioid; Stereotaxic Techniques | 1977 |
Opioid peptides and opiates differ in receptor selectivity.
Topics: Animals; Brain; Dextrorphan; Endorphins; Enkephalins; Isomerism; Levorphanol; Methadone; Morphine; Naloxone; Naltrexone; Rats; Receptors, Opioid | 1977 |
Behavioral and electrophysiological effects of peptides related to lipotropin (beta-LPH).
Topics: Adrenocorticotropic Hormone; Analgesics; Animals; Avoidance Learning; Behavior, Animal; beta-Lipotropin; Drug Interactions; Electroshock; Endorphins; Hippocampus; Male; Morphine; Motor Activity; Naltrexone; Rats; Rats, Inbred Strains; Reaction Time | 1978 |
Interaction of ligands with the opiate receptors of brain membranes: regulation by ions and nucleotides.
Topics: Animals; Brain; Enkephalins; Etorphine; Guanylyl Imidodiphosphate; Ligands; Male; Manganese; Morphine; Morphine Derivatives; Naltrexone; Rats; Receptors, Opioid; Ribonucleotides; Sodium | 1978 |
6beta-[N,N-Bis(2-chloroethyl)amino]-17-(cyclopropylmethyl)-4,5alpha-epoxy-3,14-dihydroxymorphinan(chlornaltrexamine) a potent opioid receptor alkylating agent with ultralong narcotic antagonist actitivty.
Topics: Alkylating Agents; Analgesia; Binding, Competitive; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Nitrogen Mustard Compounds; Receptors, Opioid | 1978 |
Opiate receptor agonists as modulators of gamma-aminobutyric acid turnover in the nucleus caudatus, globus pallidus and substantia nigra of the rat.
Topics: Animals; Catalepsy; Caudate Nucleus; Endorphins; gamma-Aminobutyric Acid; Globus Pallidus; Humans; Male; Morphine; Muscimol; Naltrexone; Rats; Receptors, Opioid; Substantia Nigra | 1978 |
Synthesis and pharmacologic characterization of an alkylating analogue (chlornaltrexamine) of naltrexone with ultralong-lasting narcotic antagonist properties.
Topics: Alkylating Agents; Analgesics; Animals; Humans; In Vitro Techniques; Male; Mice; Molecular Conformation; Morphine; Morphine Dependence; Naloxone; Naltrexone; Narcotic Antagonists; Nitrogen Mustard Compounds; Rats; Receptors, Opioid; Time Factors | 1979 |
Differential sensitivity to morphine-induced analgesia and motor activity in two inbred strains of mice: behavioral and biochemical correlations.
Topics: Adenylyl Cyclases; Analgesics; Animals; Brain Chemistry; Cerebellum; Corpus Striatum; Cyclic AMP; Cyclic GMP; Dopamine; Haloperidol; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Morphine; Motor Activity; Naltrexone; Species Specificity | 1979 |
Endogenous opioids participate in the regulation of the hypothalamus-pituitary-luteinizing hormone axis and testosterone's negative feedback control of luteinizing hormone.
Topics: Animals; Dose-Response Relationship, Drug; Endorphins; Gonadotropin-Releasing Hormone; Hypothalamo-Hypophyseal System; Luteinizing Hormone; Male; Morphine; Naloxone; Naltrexone; Pituitary Gland; Rats; Testosterone | 1979 |
Continuous intravenous naltrexone effects on morphine self-administration in rhesus monkeys.
Topics: Animals; Dose-Response Relationship, Drug; Haplorhini; Infusions, Parenteral; Macaca mulatta; Morphine; Naloxone; Naltrexone; Self Administration; Time Factors | 1978 |
Nitrous oxide stimulation of locomotor activity: evidence for an opiate-like behavioral effect.
Topics: Adaptation, Psychological; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Male; Mice; Morphine; Motor Activity; Naloxone; Naltrexone; Narcotics; Nitrous Oxide | 1979 |
Effects of morphine and beta-endorphin on basal and elevated plasma levels of alpha-MSH and vasopressin.
Topics: Animals; Endorphins; Injections, Intraperitoneal; Injections, Intraventricular; Male; Melanocyte-Stimulating Hormones; Morphine; Naltrexone; Rats; Vasopressins | 1979 |
Evidence supporting lack of discriminative stimulus properties of a combination of naltrexone and morphine.
Topics: Animals; Discrimination, Psychological; Drug Interactions; Generalization, Stimulus; Gerbillinae; Male; Morphine; Naloxone; Naltrexone | 1979 |
Acute effects of opiate agonists, partial agonists and antagonists on brain monoamines in the rat.
Topics: Animals; Behavior, Animal; Biogenic Amines; Brain Chemistry; Cyclazocine; Dextrorphan; Female; Levallorphan; Morphine; Nalorphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pentazocine; Rats | 1979 |
Studies of the possible role of brain endorphins in pentobarbital anesthesia and toxicity in mice.
Topics: Animals; Brain; Endorphins; Enkephalins; Leucine; Male; Mice; Morphine; Naloxone; Naltrexone; Pentobarbital; Phenylalanine | 1979 |
Behavioral effects of perinatal naltrexone exposure: a preliminary investigation.
Topics: Analgesics; Animals; Animals, Newborn; Behavior, Animal; Conditioning, Operant; Electroshock; Emotions; Female; Morphine; Motor Activity; Naloxone; Naltrexone; Pregnancy; Rats; Reaction Time | 1979 |
The effects of naltrexone on the development of physical dependence on morphine.
Topics: Animals; Behavior, Animal; Body Temperature; Brain; Drug Implants; Humans; Male; Mice; Morphine; Morphine Dependence; Naloxone; Naltrexone; Time Factors | 1978 |
Discriminative stimulus effects of naltrexone in the morphine-dependent rat.
Topics: Animals; Generalization, Stimulus; Humans; Male; Morphine; Morphine Dependence; Naloxone; Naltrexone; Narcotic Antagonists; Prejudice; Rats; Substance Withdrawal Syndrome; Time Factors | 1979 |
Central and peripheral actions of morphine on intestinal transit.
Topics: Animals; Central Nervous System; Gastrointestinal Motility; Injections, Intraventricular; Injections, Subcutaneous; Male; Morphine; Naltrexone; Rats; Vagotomy | 1978 |
Plasma corticosteroid levels in rats maintained on a long-acting naltrexone delivery system.
Topics: Adrenal Cortex Hormones; Animals; Drug Implants; Male; Morphine; Naloxone; Naltrexone; Rats; Reaction Time; Time Factors | 1978 |
Stereospecific aversive property of narcotic antagonists in morphine-free rats.
Topics: Animals; Avoidance Learning; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Stereoisomerism; Structure-Activity Relationship | 1978 |
Naltrexone, morphine and cocaine interactions in mice and rats.
Topics: Animals; Cocaine; Drug Interactions; Lethal Dose 50; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Reaction Time; Reflex | 1978 |
Midbrain raphe mediation of the narcotic blockade of ovulation.
Topics: Animals; Brain Stem; Female; Luteinizing Hormone; Mesencephalon; Methadone; Morphine; Naltrexone; Ovulation; Raphe Nuclei; Rats | 1978 |
Behavioral effects of chronic narcotic antagonist administration of infant rats.
Topics: Animals; Animals, Newborn; Behavior, Animal; Body Weight; Male; Morphine; Naltrexone; Narcotic Antagonists; Rats; Reaction Time | 1978 |
Effects of repeated injections of naltrexone on antagonism of rate decreases by morphine in the pigeon.
Topics: Animals; Behavior, Animal; Columbidae; Conditioning, Operant; Male; Morphine; Naloxone; Naltrexone; Time Factors | 1978 |
Genotype dependent response of morphine and methionine-enkephalin on the electrically induced contractions of the mouse vas deferens.
Topics: Animals; Electric Stimulation; Endorphins; Enkephalins; Genotype; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Morphine; Muscle Contraction; Muscle, Smooth; Naltrexone; Vas Deferens | 1978 |
Discriminative effects of morphine in the pigeon.
Topics: Animals; Columbidae; Dextrorphan; Discrimination, Psychological; Generalization, Psychological; Humans; Levorphanol; Morphine; Naloxone; Naltrexone; Time Factors | 1978 |
Effects of opiates on the discriminative stimulus properties of dopamine agonists.
Topics: Amphetamine; Animals; Apomorphine; Discrimination, Psychological; Dopamine; Haloperidol; Male; Morphine; Naltrexone; Narcotics; Pentazocine; Rats; Time Factors | 1978 |
On the regulation of gamma-aminobutyric acid neurons in caudatus, pallidus and nigra: effects of opioids and dopamine agonists.
Topics: Animals; Apomorphine; Brain; Caudate Nucleus; Corpus Striatum; Decerebrate State; Dopamine; Endorphins; gamma-Aminobutyric Acid; Globus Pallidus; Male; Morphine; Naltrexone; Narcotics; Neurons; Rats; Substantia Nigra | 1979 |
Development of polylactic/glycolic acid delivery systems for use in treatment of narcotic addiction.
Topics: Animals; Drug Implants; Foreign-Body Reaction; Lactates; Male; Mice; Morphine; Naloxone; Naltrexone; Polyglycolic Acid; Polymers; Reaction Time; Time Factors | 1976 |
Assessment of CNS drug activity in rhesus monkeys by analysis of the EEG.
Topics: Amobarbital; Animals; Brain; Clorazepate Dipotassium; Codeine; Computers; Electroencephalography; Glutethimide; Haplorhini; Macaca mulatta; Morphine; Nalbuphine; Naloxone; Naltrexone | 1976 |
[Precipitation and prevention of abstinence in acutely morphinized rats and mice: comparisons between naloxone, naltrexone, and diprenorphine (author's transl)].
Topics: Animals; Diprenorphine; Humans; Male; Mice; Morphinans; Morphine; Morphine Dependence; Naloxone; Naltrexone; Rats; Substance Withdrawal Syndrome; Time Factors | 1976 |
Blockade of the discriminative effects of morphine in the rat by naltrexone and naloxone.
Topics: Administration, Oral; Animals; Cues; Discrimination, Psychological; Dose-Response Relationship, Drug; Injections, Subcutaneous; Male; Morphine; Naloxone; Naltrexone; Rats; Time Factors | 1976 |
Testing of drug delivery systems for use in the treatment of narcotic addiction.
Topics: Animals; Blood Proteins; Dogs; Drug Implants; Guinea Pigs; Haplorhini; Humans; Kinetics; Mice; Morphine; Naloxone; Naltrexone; Protein Binding; Rats; Reaction Time; Species Specificity; Substance-Related Disorders | 1975 |
Evaluation of narcotic and narcotic antagonist interactions in primates.
Topics: Animals; Cyclazocine; Dextroamphetamine; Diazepam; Drug Interactions; Ethanol; Female; Haplorhini; Humans; Macaca mulatta; Male; Methadone; Methadyl Acetate; Morphine; Morphine Dependence; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Phenytoin; Secobarbital; Self Administration | 1976 |
Constant rate infusion of deuterated phosphorylcholine to measure the effects of morphine on acetylcholine turnover rate in specific nuclei of rat brain.
Topics: Acetylcholine; Amygdala; Animals; Brain; Cerebral Cortex; Choline; Hippocampus; Kinetics; Male; Medulla Oblongata; Mesencephalon; Morphine; Naltrexone; Olfactory Bulb; Phosphorylcholine; Rats; Substantia Nigra; Time Factors | 1977 |
Stereochemical studies on medicinal agents. 23. Synthesis and biological evaluation of 6-amino derivatives of naloxone and naltrexone.
Topics: Amination; Analgesics; Animals; Binding, Competitive; In Vitro Techniques; Male; Mice; Morphine; Naloxone; Naltrexone; Stereoisomerism | 1977 |
Inhibition of acetylcholine turnover in rat hippocampus by intraseptal injections of beta-endorphin and morphine.
Topics: Acetylcholine; Analgesia; Animals; Brain; Cerebral Cortex; Choline; Corpus Striatum; Depression, Chemical; Endorphins; Hippocampus; Injections; Male; Morphine; Naltrexone; Rats; Reaction Time | 1977 |
Effects of acute and chronic morphine and narcotic antagonists on brain energy metabolism.
Topics: Animals; Brain; Citrates; Energy Metabolism; Glucose; Malates; Male; Mice; Morphine; Naloxone; Naltrexone; Pyruvates | 1977 |
The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog.
Topics: Animals; Apomorphine; Cyclazocine; Cyclopropanes; Dextropropoxyphene; Dogs; Ethylketocyclazocine; Humans; Morphinans; Morphine; Morphine Dependence; Nalorphine; Naltrexone; Phenazocine; Spinal Cord | 1976 |
Reinstatement of precipitated narcotic withdrawal hypothermia in the rat.
Topics: Animals; Body Temperature; Female; Humans; Morphine; Naloxone; Naltrexone; Rats; Substance Withdrawal Syndrome; Substance-Related Disorders | 1976 |
The structure-action relationship and kinetics of some naloxone and naltrexone derivatives.
Topics: Animals; Cyclazocine; Guinea Pigs; Ileum; Kinetics; Morphine; Morphine Derivatives; Muscle Contraction; Naloxone; Naltrexone; Narcotic Antagonists; Structure-Activity Relationship; Time Factors | 1976 |
Long-acting narcotic antagonist complexes.
Topics: Animals; Brain; Diprenorphine; Methadone; Mice; Morphine; Naltrexone; Narcotic Antagonists; Reaction Time; Time Factors | 1976 |
Sustained release of naltrexone from glyceride implants.
Topics: Animals; Delayed-Action Preparations; Drug Implants; Glycerides; Male; Mice; Morphine; Naloxone; Naltrexone; Reaction Time; Time Factors | 1976 |
Use of synthetic polypeptides in the preparation of biodegradable delivery vehicles for narcotic antagonists.
Topics: Animals; Biodegradation, Environmental; Drug Implants; Mice; Morphine; Naltrexone; Narcotic Antagonists; Peptides; Reaction Time; Time Factors | 1976 |
Development of Chronomers tm for narcotic antagonists.
Topics: Animals; Biodegradation, Environmental; Drug Implants; Injections, Subcutaneous; Kinetics; Mice; Morphine; Naltrexone; Narcotic Antagonists; Polymers; Rats; Reaction Time | 1976 |
Morphine-naloxone interaction in the central cholinergic system: the influence of subcortical lesioning and electrical stimulation.
Topics: Acetylcholine; Animals; Brain; Cerebral Cortex; Drug Interactions; Electric Stimulation; In Vitro Techniques; Morphine; Naloxone; Naltrexone; Parasympathetic Nervous System; Rats; Time Factors | 1976 |
Nitrous oxide "analgesia": resemblance to opiate action.
Topics: Analgesia; Animals; Drug Tolerance; Mice; Morphine; Naloxone; Naltrexone; Nitrous Oxide | 1976 |
Ethanol preference in the hamster: effects of morphine sulfate and naltrexone, a long-acting morphine antagonist.
Topics: Alcohol Drinking; Animals; Choice Behavior; Cricetinae; Decision Making; Dextrorphan; Levorphanol; Morphine; Naloxone; Naltrexone; Time Factors | 1976 |
Psychopathology and mood during heroin use: acute vs chronic effects.
Topics: Acute Disease; Adult; Chronic Disease; Dose-Response Relationship, Drug; Drug Therapy, Combination; Emotions; Euphoria; Heroin; Heroin Dependence; Humans; Male; Methadone; Morphine; Motor Activity; Naloxone; Naltrexone; Psychopathology | 1976 |
Correlation between analgesia and the decrease of acetylcholine turnover rate in cortex and hippocampus elicited by morphine, meperidine, viminol R2 and azidomorphine.
Topics: Acetylcholine; Analgesia; Animals; Cerebral Cortex; Corpus Striatum; Depression, Chemical; Ethanolamines; Hippocampus; Kinetics; Male; Meperidine; Morphine; Morphine Derivatives; Naltrexone; Rats | 1976 |
Interactions of narcotics, narcotic antagonists, and ethanol during acute, chronic, and withdrawal states.
Topics: Alcohol Drinking; Animals; Animals, Newborn; Dextrorphan; Drug Interactions; Ethanol; Humans; Levorphanol; Male; Methadone; Methadyl Acetate; Mice; Mice, Inbred C57BL; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors | 1976 |
Comparative in vivo distribution of opiate agonists and antagonists by means of double isotope techniques.
Topics: Animals; Autoradiography; Blood-Brain Barrier; Brain; Carbon Radioisotopes; Dose-Response Relationship, Drug; Liver; Male; Morphine; Naloxone; Naltrexone; Rats; Time Factors; Tritium | 1975 |
Acetylcholine storage and its stabilization by morphine.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Chemical Phenomena; Chemistry; In Vitro Techniques; Kinetics; Magnetic Resonance Spectroscopy; Morphine; Naloxone; Naltrexone; Sodium Chloride; Spectrometry, Fluorescence; Synaptosomes | 1975 |
Clinical experience with naltrexone.
Topics: Administration, Oral; Adult; Female; Heroin Dependence; Hospitalization; Humans; Male; Methadone; Middle Aged; Morphine; Naloxone; Naltrexone; Outpatient Clinics, Hospital; Patient Dropouts; Placebos; Time Factors | 1975 |
Long-acting narcotic antagonist complexes.
Topics: Aluminum; Animals; Brain; Buffers; Chemistry, Pharmaceutical; Delayed-Action Preparations; Diprenorphine; Drug Stability; Methadone; Mice; Morphine; Naltrexone; Narcotic Antagonists; Reaction Time; Zinc | 1975 |
Sustained release of naltrexone from glyceride implants.
Topics: Animals; Biodegradation, Environmental; Chemistry, Pharmaceutical; Drug Implants; Glycerides; Histocompatibility; Mice; Morphine; Naloxone; Naltrexone; Reaction Time; Time Factors | 1975 |
Use of synthetic polypeptides in the preparation of biodegradable delivery vehicles for narcotic antagonists.
Topics: Animals; Biodegradation, Environmental; Drug Implants; Glutamates; Leucine; Mice; Morphine; Naloxone; Naltrexone; Peptides; Reaction Time; Time Factors | 1975 |
Heroin addiction. Sequential treatment employing pharmacologic supports.
Topics: Heroin Dependence; Humans; Methadone; Morphine; Naltrexone; Prognosis; Recurrence | 1976 |
An evaluation of the hot plate technique to study narcotic antagonists.
Topics: Animals; Male; Methods; Mice; Models, Biological; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Reaction Time; Time Factors | 1976 |
Involvement of opioid mechanisms in peripheral motor control of detrusor muscle.
Topics: Animals; Electric Stimulation; Enkephalins; Ganglionic Blockers; Hexamethonium; Hexamethonium Compounds; Humans; Indoles; Male; Morphinans; Morphine; Muscle Contraction; Muscles; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Substance P; Sympatholytics | 1992 |
Perinatal morphine exposure alters peptidergic development in the striatum.
Topics: Animals; Blotting, Northern; Body Weight; Corpus Striatum; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Growth; Immunohistochemistry; In Situ Hybridization; Morphine; Naloxone; Naltrexone; Protein Precursors; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Substance P | 1992 |
Morphine induces an increase in extracellular serotonin in the rat diencephalon.
Topics: Animals; Behavior, Animal; Catalepsy; Chromatography, High Pressure Liquid; Dialysis; Diencephalon; Electrochemistry; Hydroxyindoleacetic Acid; Male; Morphine; Naltrexone; Rats; Rats, Sprague-Dawley; Reaction Time; Serotonin | 1992 |
Agonist and antagonist activity of kappa opioids in the squirrel monkey: I. Antinociception and urine output.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Behavior, Animal; Benzodiazepines; Benzomorphans; Drug Interactions; Ethylketocyclazocine; Male; Methadone; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Nociceptors; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Saimiri; Urination | 1992 |
Agonist and antagonist activity of kappa opioids in the squirrel monkey: II. Effect of chronic morphine treatment.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzodiazepines; Benzomorphans; Drug Interactions; Drug Tolerance; Ethylketocyclazocine; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Nociceptors; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Saimiri; Shock; Time Factors | 1992 |
Nonconventional opioid binding sites mediate growth inhibitory effects of methadone on human lung cancer cells.
Topics: Binding Sites; Calcium; Cell Death; Cell Division; Cell Membrane; Cyclic AMP; Cycloheximide; Dactinomycin; Growth Inhibitors; Humans; Methadone; Morphine; Naltrexone; Nicotine; Pertussis Toxin; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Stereoisomerism; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1992 |
Kappa opioid mediation of fetal responses to milk.
Topics: Aging; Animals; Arousal; Chemoreceptor Cells; Dose-Response Relationship, Drug; Female; Fetal Movement; Gestational Age; Morphine; Motor Activity; Naloxone; Naltrexone; Pregnancy; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Sucking Behavior; Taste; Touch | 1992 |
Activation of the zinc finger encoding gene krox-20 in adult rat brain: comparison with zif268.
Topics: Animals; Apomorphine; Benzazepines; Brain; DNA-Binding Proteins; Early Growth Response Protein 1; Early Growth Response Protein 2; Electroshock; Haloperidol; Immediate-Early Proteins; Male; Morphine; Naltrexone; Nucleic Acid Hybridization; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Reserpine; Seizures; Substance Withdrawal Syndrome; Transcription Factors; Transcription, Genetic; Zinc Fingers | 1992 |
Maintenance of acute morphine tolerance in mice by selective blockage of kappa opioid receptors with norbinaltorphimine.
Topics: Animals; Drug Tolerance; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Receptors, Opioid, kappa; Spinal Cord | 1992 |
Effect of adrenal and sex hormones on opioid analgesia and opioid receptor regulation.
Topics: Adrenal Cortex Hormones; Adrenalectomy; Analgesics; Animals; Brain; Female; Gonadal Steroid Hormones; Male; Methadone; Mice; Morphine; Naltrexone; Narcotics; Orchiectomy; Ovariectomy; Reaction Time; Receptors, Opioid; Sex Characteristics; Up-Regulation | 1992 |
Pentobarbital attenuates antinociception induced by i.c.v. morphine but not beta-endorphin in the mouse.
Topics: Animals; beta-Endorphin; Drug Interactions; Enkephalin, Leucine; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Narcotic Antagonists; Nociceptors; Pentobarbital; Receptors, Opioid | 1992 |
Spinal antinociception by Tyr-D-Ser(otbu)-Gly-Phe-Leu-Thr, a selective delta-opioid receptor agonist.
Topics: Amino Acid Sequence; Analgesics; Animals; Dose-Response Relationship, Drug; Indoles; Injections, Spinal; Male; Molecular Sequence Data; Morphinans; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta | 1992 |
Clocinnamox: a novel, systemically-active, irreversible opioid antagonist.
Topics: Analgesia; Animals; Cinnamates; Dose-Response Relationship, Drug; Fentanyl; Male; Mice; Morphine; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Receptors, Opioid | 1992 |
Isobolographic and dose-response analyses of the interaction between intrathecal mu and delta agonists: effects of naltrindole and its benzofuran analog (NTB).
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Indoles; Injections, Spinal; Male; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu | 1992 |
Chronic d-amphetamine inhibits opioid receptor antagonist-induced supersensitivity.
Topics: Animals; Dextroamphetamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Mice; Morphine; Naltrexone; Receptors, Opioid; Up-Regulation | 1992 |
Diprenorphine as a stimulus in drug discrimination learning.
Topics: Animals; Chlorides; Conditioning, Psychological; Diprenorphine; Discrimination Learning; Dose-Response Relationship, Drug; Female; Generalization, Psychological; Lithium; Lithium Chloride; Morphine; Nalorphine; Naloxone; Naltrexone; Pentobarbital; Rats | 1992 |
Opioid receptor antagonist affinity ligands: 6 beta-bromoacetamido-6-desoxynaltrexone and 6 beta-thioglycolamido-6-desoxynaltrexone.
Topics: Affinity Labels; Analgesia; Animals; Brain; Cattle; Cell Membrane; Hydrogen-Ion Concentration; Kinetics; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Nicotine; Quinuclidinyl Benzilate; Receptors, Opioid | 1992 |
Morphine- and naltrexone-induced modification of palatability: analysis by the taste reactivity test.
Topics: Animals; Arousal; Avoidance Learning; Brain; Dose-Response Relationship, Drug; Male; Morphine; Naltrexone; Quinine; Rats; Receptors, Opioid; Sucrose; Taste; Taste Threshold | 1992 |
Opioid receptors mediating antinociception from beta-endorphin and morphine in the periaqueductal gray.
Topics: Amino Acid Sequence; Analgesics; Animals; beta-Endorphin; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Injections, Intraventricular; Male; Molecular Sequence Data; Morphine; Naltrexone; Narcotic Antagonists; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid | 1992 |
Discriminative stimulus effects of cyclorphan: selective antagonism with naltrexone.
Topics: Animals; Columbidae; Dextrorphan; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Generalization, Psychological; Levorphanol; Morphinans; Morphine; Naltrexone; Receptors, Opioid; Receptors, Opioid, mu; Stereoisomerism | 1992 |
Naloxone and norbinaltorphimine administered intracerebroventricularly antagonize spinal morphine-induced antinociception in mice through the antianalgesic action of spinal dynorphin A (1-17).
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Dynorphins; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Naltrexone | 1992 |
Partial characterization of a neurotransmitter pathway regulating the in vivo release of prolactin.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Bromocriptine; Haloperidol; Male; Mecamylamine; Methysergide; Morphine; Naltrexone; Narcotic Antagonists; Neurotransmitter Agents; Nicotine; Nicotinic Antagonists; Pituitary Gland; Prolactin; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Nicotinic; Receptors, Opioid; Receptors, Serotonin; Serotonin Antagonists; Tetrahydronaphthalenes | 1992 |
Modulation of acute morphine tolerance by corticotropin-releasing factor and dynorphin A in the mouse spinal cord.
Topics: Animals; Corticotropin-Releasing Hormone; Drug Tolerance; Dynorphins; Injections, Spinal; Male; Mice; Morphine; Naltrexone; Peptide Fragments; Spinal Cord | 1992 |
Tyr-MIF-1 and hemorphin can act as opiate agonists as well as antagonists in the guinea pig ileum.
Topics: Amino Acid Sequence; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Hemoglobins; Ileum; In Vitro Techniques; Male; Molecular Sequence Data; Morphine; MSH Release-Inhibiting Hormone; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists; Peptide Fragments; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1992 |
Effects of the opiates on the paraventricular nucleus in genetically polydipsic mice.
Topics: Animals; Dynorphins; Female; In Vitro Techniques; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Microinjections; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Neurons; Paraventricular Hypothalamic Nucleus; Quaternary Ammonium Compounds; Synapses; Thirst | 1992 |
Discriminative stimulus properties of cocaine, alone and in combination with buprenorphine, morphine and naltrexone.
Topics: Animals; Buprenorphine; Cocaine; Dextroamphetamine; Discrimination, Psychological; Dose-Response Relationship, Drug; Drug Combinations; Male; Morphine; Naltrexone; Rats; Sodium Chloride | 1992 |
Reinstatement of heroin self-administration habits: morphine prompts and naltrexone discourages renewed responding after extinction.
Topics: Animals; Conditioning, Operant; Extinction, Psychological; Heroin Dependence; Injections, Intravenous; Morphine; Nalorphine; Naltrexone; Rats; Rats, Sprague-Dawley; Self Administration | 1992 |
Repeated systemic administration of the mixed inhibitor of enkephalin-degrading enzymes, RB101, does not induce either antinociceptive tolerance or cross-tolerance with morphine.
Topics: Analgesics; Animals; Disulfides; Dose-Response Relationship, Drug; Drug Tolerance; Indoles; Male; Mice; Morphinans; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Phenylalanine; Prodrugs; Reaction Time | 1992 |
Naltrindole retards tolerance development to morphine-induced effects on EEG and EEG power spectra.
Topics: Animals; Brain; Drug Tolerance; Electroencephalography; Female; Indoles; Injections, Intraventricular; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains | 1992 |
Effects of nor-binaltorphimine on the development of analgesic tolerance to and physical dependence on morphine.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics; Analysis of Variance; Animals; Behavior, Animal; Body Weight; Drug Tolerance; Male; Mice; Morphine; Morphine Dependence; Naltrexone; Pyrrolidines; Rats | 1992 |
Differential effects of morphine and naltrexone on the antibody response in various mouse strains.
Topics: Animals; Antibody Formation; Drug Interactions; Female; Immune Tolerance; Male; Mice; Mice, Inbred Strains; Morphine; Naltrexone; Organ Size; Species Specificity; Spleen | 1992 |
The effect of lipase on the release of naltrexone from triglyceride-coated cellulose acetate phthalate microspheres.
Topics: Biocompatible Materials; Cellulose; Drug Delivery Systems; Enzyme Activation; Lipase; Materials Testing; Microscopy, Electron, Scanning; Microspheres; Morphine; Naltrexone; Triglycerides | 1992 |
Apparent pA2 value of naltrexone is not changed in rats following continuous exposure to morphine or naloxone.
Topics: Analysis of Variance; Animals; Body Weight; Dose-Response Relationship, Drug; Drug Interactions; Fentanyl; Male; Morphine; Naloxone; Naltrexone; Pain Measurement; Rats; Rats, Inbred Strains | 1992 |
Opioid modulation of alcohol intake in monkeys by low doses of naltrexone and morphine.
Topics: Alcohol Drinking; Animals; Dose-Response Relationship, Drug; Macaca mulatta; Male; Morphine; Naltrexone | 1992 |
Pentazocine-induced biphasic analgesia in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics; Animals; Drug Administration Schedule; Drug Interactions; Drug Tolerance; Indoles; Injections, Intraventricular; Male; Mice; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Pentazocine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Time Factors | 1991 |
The partial opioid agonist, buprenorphine, protects against lethal effects of cocaine.
Topics: Animals; Brain; Buprenorphine; Cocaine; Dose-Response Relationship, Drug; Methadone; Mice; Mice, Inbred Strains; Morphine; Naltrexone; Receptors, Opioid; Receptors, Opioid, mu; Seizures | 1991 |
Selective blockage of delta opioid receptors prevents the development of morphine tolerance and dependence in mice.
Topics: Animals; Drug Implants; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Indoles; Isothiocyanates; Male; Mice; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Nociceptors; Receptors, Opioid; Receptors, Opioid, delta; Substance-Related Disorders; Thiocyanates | 1991 |
Ontogeny of mu- and kappa-opiate receptor control of the hypothalamo-pituitary-adrenal axis in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenal Glands; Adrenocorticotropic Hormone; Animals; Corticosterone; Dexamethasone; Female; Hypothalamus; Kinetics; Morphine; Naltrexone; Pituitary Gland; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1991 |
Mirfentanil: pharmacological profile of a novel fentanyl derivative with opioid and nonopioid effects.
Topics: Alfentanil; Analgesics; Animals; Columbidae; Discrimination Learning; Female; Fentanyl; In Vitro Techniques; Macaca mulatta; Male; Morphine; Naltrexone; Receptors, Opioid; Receptors, Opioid, mu; Respiration; Self Administration; Structure-Activity Relationship | 1991 |
Characteristics of dose-dependent antagonism by beta-funaltrexamine of the antinociceptive effects of intrathecal mu agonists.
Topics: Analgesics; Animals; Binding, Competitive; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fentanyl; Injections, Spinal; Male; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Spinal Cord; Sufentanil | 1991 |
Dissociation of opioid receptor upregulation and functional supersensitivity.
Topics: Analgesia; Animals; Binding Sites; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Kinetics; Male; Mice; Morphine; Naltrexone; Pertussis Toxin; Receptors, Opioid; Up-Regulation; Virulence Factors, Bordetella | 1991 |
Opioids regulate the release of human chorionic gonadotropin hormone from trophoblast tissue.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Benzeneacetamides; Chorionic Gonadotropin; Endorphins; Female; Humans; Morphine; Naltrexone; Placenta; Pregnancy; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Trophoblasts | 1991 |
Footshock- and psychological-stress prevent the development of tolerance to spinal but not supraspinal morphine.
Topics: Animals; Drug Administration Routes; Drug Tolerance; Electroshock; Injections, Intraventricular; Injections, Spinal; Injections, Subcutaneous; Male; Mice; Mice, Inbred Strains; Morphine; Naltrexone; Receptors, Opioid; Stress, Psychological | 1991 |
Isolation-induced vocalization in Wistar rat pups is not increased by naltrexone.
Topics: Animals; Arousal; Brain; Dose-Response Relationship, Drug; Endorphins; Maternal Deprivation; Morphine; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Social Isolation; Ultrasonics; Vocalization, Animal | 1991 |
Evaluation of receptor mechanism mediating fentanyl analgesia and toxicity.
Topics: Analgesics; Animals; Brain; Drug Tolerance; Fentanyl; Lethal Dose 50; Male; Mice; Morphine; Naloxone; Naltrexone; Receptors, Opioid | 1991 |
Delta receptor involvement in morphine suppression of noxiously evoked activity of spinal WDR neurons in cats.
Topics: Analgesia; Animals; Cats; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Evoked Potentials; Female; Hot Temperature; Injections, Spinal; Male; Morphine; Naltrexone; Narcotic Antagonists; Neurons; Pain; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord | 1991 |
Selective antagonism by naltrindole of the antinociceptive effects of the delta opioid agonist cyclic[D-penicillamine2-D-penicillamine5]enkephalin in the rat.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Indoles; Injections, Spinal; Injections, Subcutaneous; Male; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Nociceptors; Pain Measurement; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord | 1991 |
In vitro effect of high doses of morphine on Con A induced lymphokine production.
Topics: Animals; beta-Endorphin; Cell Survival; Cells, Cultured; Clone Cells; Colforsin; Concanavalin A; Cyclic AMP; Depression, Chemical; Dinoprostone; Dose-Response Relationship, Drug; Enkephalins; Female; Lymphocyte Activation; Lymphokines; Mice; Mice, Inbred C57BL; Morphine; Naloxone; Naltrexone; Protein Biosynthesis; Receptors, Opioid; Spleen; T-Lymphocytes, Helper-Inducer | 1991 |
Evaluation of the sites of opioid influence on anterior pituitary hormone secretion using a quaternary opiate antagonist.
Topics: Analgesia; Animals; Brain Mapping; Male; Morphine; Naltrexone; Narcotic Antagonists; Neurons; Pain Measurement; Pituitary Hormones, Anterior; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu | 1991 |
Role of spinal kappa opioid receptors in the blockade of the development of antinociceptive tolerance to morphine.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Drug Tolerance; Injections, Intraventricular; Injections, Spinal; Injections, Subcutaneous; Male; Mice; Morphine; Naltrexone; Nociceptors; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Spinal Cord | 1991 |
Modulation of mu-mediated antitussive activity in rats by a delta agonist.
Topics: Aerosols; Animals; Antitussive Agents; Capsaicin; Cisterna Magna; Cough; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Indoles; Injections; Male; Morphinans; Morphine; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1991 |
Effects of intracerebroventricular beta-funaltrexamine on mu and delta opioid receptors in the rat: dichotomy between binding and antinociception.
Topics: Animals; Brain; Cerebral Cortex; Corpus Striatum; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intravenous; Kinetics; Male; Morphine; Naltrexone; Narcotic Antagonists; Nociceptors; Periaqueductal Gray; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Thalamus; Time Factors; Tritium | 1991 |
Spinal kappa receptor-mediated analgesia of E-2078, a systemically active dynorphin analog, in mice.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Dynorphins; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Peptide Fragments; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1991 |
Separate neural mechanisms mediate sufentanil-induced pupillary responses in the cat.
Topics: Analgesics, Opioid; Animals; Cats; Clonidine; Drug Interactions; Fentanyl; Male; Morphine; Mydriasis; Naltrexone; Pupil; Receptors, Opioid; Receptors, Opioid, mu; Sufentanil | 1991 |
Involvement of spinal kappa opioid receptors in the antagonistic effect of dynorphins on morphine antinociception.
Topics: Animals; Dynorphins; Indoles; Male; Mice; Morphinans; Morphine; Naltrexone; Pain; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Spine; Stereoisomerism | 1991 |
Naltrexone-sensitizing effects of centrally administered morphine and opioid peptides.
Topics: Animals; Conditioning, Operant; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Morphine; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta | 1991 |
Serotonin contributes to the spinal antinociceptive effects of morphine.
Topics: Adrenergic alpha-Antagonists; Adrenergic Antagonists; Analgesics; Animals; Biogenic Monoamines; Dose-Response Relationship, Drug; Injections, Spinal; Male; Morphine; Naltrexone; Nerve Endings; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Opioid; Serotonin; Serotonin Antagonists; Spinal Cord | 1991 |
EEG evidence that morphine and an enkephalin analog cross the blood-brain barrier.
Topics: Amino Acid Sequence; Animals; Blood-Brain Barrier; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Electroencephalography; Male; Molecular Sequence Data; Morphine; MSH Release-Inhibiting Hormone; Naltrexone; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains | 1991 |
Chronic morphine administration augments benzodiazepine binding and GABAA receptor function.
Topics: Animals; Brain Chemistry; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chlorides; Chlorine; Flunitrazepam; In Vitro Techniques; Ion Channels; Male; Mice; Morphine; Muscimol; Naltrexone; Radioisotopes; Receptors, GABA-A; Sulfur Radioisotopes | 1990 |
Induction of the c-fos proto-oncogene during opiate withdrawal in the locus coeruleus and other regions of rat brain.
Topics: Animals; Blotting, Northern; Brain; DNA-Binding Proteins; Locus Coeruleus; Male; Morphine; Naltrexone; Organ Specificity; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Proto-Oncogenes; Rats; Rats, Inbred Strains; RNA; RNA, Messenger; Substance Withdrawal Syndrome; Transcription Factors | 1990 |
Chronic opioids impair acquisition of both radial maze and Y-maze choice escape.
Topics: Animals; Avoidance Learning; Behavior, Animal; Cognition; Drug Tolerance; Electroshock; Learning; Morphine; Naltrexone; Narcotics; Rats; Reaction Time; Sensory Thresholds; Vocalization, Animal | 1991 |
Naltrexone does not reverse the inhibitory effect of chronic restraint on gonadotropin secretion in the intact male rat.
Topics: Animals; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Hypothalamus; Luteinizing Hormone; Male; Morphine; Naltrexone; Orchiectomy; Rats; Rats, Inbred Strains; Restraint, Physical; Stress, Physiological | 1991 |
Morphine-induced thymic hypoplasia is glucocorticoid-dependent.
Topics: Adrenalectomy; Animals; Antigens, Differentiation, T-Lymphocyte; CD3 Complex; CD4 Antigens; CD8 Antigens; Dexamethasone; Glucocorticoids; Mice; Mice, Inbred C57BL; Morphine; Naltrexone; Receptors, Antigen, T-Cell; Receptors, Interleukin-2; T-Lymphocyte Subsets; Thymus Gland | 1991 |
NMDA receptor antagonists suppress behaviors but not norepinephrine turnover or locus coeruleus unit activity induced by opiate withdrawal.
Topics: Animals; Behavior, Animal; Dizocilpine Maleate; Electrophysiology; Isoquinolines; Locus Coeruleus; Male; Morphine; Naltrexone; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome | 1991 |
Pharmacodynamic and pharmacokinetic actions of ketocyclazocine enantiomers in the dog: absence of sigma- or phencyclidine-like activity.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Behavior, Animal; Dogs; Dose-Response Relationship, Drug; Drug Administration Schedule; Ethylketocyclazocine; Female; Morphine; Naltrexone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, sigma; Stereoisomerism; Time Factors | 1991 |
The role of opioid receptor density in morphine tolerance.
Topics: Animals; Drug Tolerance; Male; Mice; Morphine; Naltrexone; Receptors, Opioid; Species Specificity; Up-Regulation | 1991 |
Antagonism of morphine antinociception by intrathecally administered corticotropin-releasing factor in mice.
Topics: Analgesia; Animals; Corticotropin-Releasing Hormone; Dose-Response Relationship, Drug; Injections, Spinal; Male; Mice; Morphine; Naltrexone; Receptors, Opioid; Receptors, Opioid, kappa | 1991 |
Effects of selective opiate antagonists on morphine-induced hyperalgesia in domestic fowl.
Topics: Analgesia; Animals; Chickens; Dose-Response Relationship, Drug; Hot Temperature; Indoles; Injections, Intraventricular; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Respiration | 1991 |
Comparison of naloxonazine and beta-funaltrexamine antagonism of mu 1 and mu 2 opioid actions.
Topics: Animals; Drug Administration Schedule; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Subcutaneous; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, mu | 1991 |
Endothelin-1-induced nociception.
Topics: Animals; Endothelins; Male; Mice; Morphine; Naloxone; Naltrexone; Pain; Pain Measurement | 1991 |
Effect of morphine administration on rat liver metallothionein and zinc metabolism.
Topics: Animals; Immobilization; Injections, Subcutaneous; Liver; Male; Metallothionein; Mifepristone; Morphine; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Zinc | 1991 |
Opioid-dependent behaviors in infant rats: effects of prenatal exposure to ethanol.
Topics: Aging; Analgesia; Animals; Animals, Newborn; Behavior, Animal; Birth Weight; Diet; Ethanol; Female; Morphine; Naltrexone; Nociceptors; Opioid-Related Disorders; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred Strains; Social Isolation; Stress, Psychological; Vocalization, Animal | 1991 |
Variable-ratio schedules of timeout from avoidance: effects of d-amphetamine and morphine.
Topics: Animals; Arousal; Attention; Avoidance Learning; Dextroamphetamine; Male; Morphine; Naltrexone; Rats; Reinforcement Schedule | 1991 |
Long-acting agonist and antagonist activities of naltrexamine bivalent ligands in mice.
Topics: Analgesics; Animals; Injections, Intraventricular; Injections, Subcutaneous; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Receptors, Opioid; Receptors, Opioid, mu | 1990 |
The opioid receptor selectivity for trimebutine in isolated tissues experiments and receptor binding studies.
Topics: Animals; Drug Tolerance; Guinea Pigs; Ileum; Male; Mice; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Rabbits; Receptors, Opioid; Trimebutine; Vas Deferens | 1990 |
Pharmacologic profile of NPC 168 (naltrexone phenyl oxime), a novel compound with activity at opioid receptors.
Topics: Animals; Binding, Competitive; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Food Deprivation; Guinea Pigs; Injections, Intraventricular; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Reaction Time; Reinforcement Schedule | 1990 |
beta-Funaltrexamine antagonizes the analgesic effects of mu and kappa agonists in the formalin test.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Dose-Response Relationship, Drug; Ethylketocyclazocine; Formaldehyde; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Urination | 1990 |
Antinociceptive effects of elevated plus-maze exposure: influence of opiate receptor manipulations.
Topics: Animals; Anxiety; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred DBA; Morphine; Naltrexone; Pain; Pain Measurement; Receptors, Opioid | 1990 |
Clonidine, administered intracerebroventricularly in mice, produces an anti-analgesic effect which may be mediated spinally by dynorphin A (1-17).
Topics: Analgesics; Animals; Clonidine; Dynorphins; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Reaction Time | 1990 |
Increased sensitivity to rate-altering and discriminative stimulus effects of morphine following continuous exposure to naltrexone.
Topics: Animals; Discrimination Learning; Discrimination, Psychological; Infusions, Intravenous; Male; Morphine; Naltrexone; Rats; Rats, Inbred Strains; Reaction Time; Reinforcement Schedule | 1991 |
Delta opioid antagonist, naltrindole, selectively blocks analgesia induced by DPDPE but not DAGO or morphine.
Topics: Analgesia; Analgesics; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Indoles; Injections, Intraventricular; Male; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Reaction Time; Restraint, Physical; Stress, Psychological | 1991 |
Inhibition of calcium mobilization is an early event in opiate-induced immunosuppression.
Topics: Animals; Biological Transport, Active; Calcium; Concanavalin A; Dexamethasone; Flow Cytometry; Immune Tolerance; Mice; Mice, Inbred C57BL; Morphine; Naltrexone; Narcotics; Spleen; T-Lymphocytes | 1991 |
Using antagonists to assess neurochemical coding of a drug's ability to establish a conditioned place preference.
Topics: Analgesics; Animals; Brain Chemistry; Conditioning, Operant; Flumazenil; Habituation, Psychophysiologic; Male; Morphine; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Scopolamine | 1990 |
Independence of benzodiazepine and opiate action in the suppression of isolation distress in rat pups.
Topics: Animals; Arousal; Chlordiazepoxide; Dose-Response Relationship, Drug; Flumazenil; Morphine; Motor Activity; Naltrexone; Rats; Rats, Inbred Strains; Social Isolation; Vocalization, Animal | 1990 |
The role of pituitary beta-endorphin in mediating corticotropin-releasing factor-induced antinociception.
Topics: Analgesics; Animals; beta-Endorphin; Corticotropin-Releasing Hormone; Dexamethasone; Male; Morphine; Naltrexone; Pain; Pituitary Gland; Radioimmunoassay; Rats; Rats, Inbred Strains; Reference Values; Time Factors | 1990 |
Kappa opioid partial agonist activity of the enkephalin-like pentapeptide BW942C based on urination and in vitro studies in humans and animals.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adult; Amino Acid Sequence; Animals; Diuresis; Dose-Response Relationship, Drug; Drug Tolerance; Enkephalin, Methionine; Enkephalins; Humans; In Vitro Techniques; Male; Molecular Sequence Data; Morphine; Naltrexone; Oligopeptides; Phenazocine; Pyrrolidines; Rabbits; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Urination; Vas Deferens | 1990 |
Suppression of lymphocyte activity after acute morphine administration appears to be glucocorticoid independent.
Topics: Animals; Corticosterone; Immunosuppressive Agents; Killer Cells, Natural; Lymphocyte Activation; Lymphocytes; Morphine; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Spleen | 1990 |
High-dose oral naltrexone: aversive response in drug-naive rat.
Topics: Animals; Avoidance Learning; Brain; Conditioning, Classical; Dose-Response Relationship, Drug; Drinking; Male; Morphine; Naltrexone; Nociceptors; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Opioid; Taste | 1990 |
Apparent affinity of opioid antagonists in morphine-treated rhesus monkeys discriminating between saline and naltrexone.
Topics: Animals; Discrimination Learning; Dose-Response Relationship, Drug; Female; Indoles; Macaca mulatta; Morphinans; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, mu | 1990 |
Mu antagonist and kappa agonist properties of beta-funaltrexamine (beta-FNA) in vivo: long-lasting spinal analgesia in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics; Animals; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1990 |
Morphine inhibition of lymphocyte activity is mediated by an opioid dependent mechanism.
Topics: Animals; Cell Division; Cell Survival; Corticosterone; Hypothalamo-Hypophyseal System; Immunity, Cellular; Killer Cells, Natural; Lymphocytes; Male; Morphine; Naltrexone; Pituitary-Adrenal System; Rats; Rats, Inbred Strains; Receptors, Opioid; Spleen | 1990 |
The ontogeny of opioid receptors mediating opiate-induced feeding in rats.
Topics: Aging; Animals; Body Weight; Eating; Female; Male; Morphine; Naltrexone; Narcotics; Rats; Receptors, Opioid | 1990 |
Role of opiates in striatal D-1 dopamine receptor supersensitivity induced by chronic L-dopa treatment.
Topics: Adenylyl Cyclases; Animals; Apomorphine; Corpus Striatum; Drug Interactions; Hydroxydopamines; Levodopa; Male; Morphine; Naltrexone; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Opioid | 1990 |
Delta but not mu-opioid receptors in the spinal cord are involved in antinociception induced by beta-endorphin given intracerebroventricularly in mice.
Topics: Analgesia; Animals; beta-Endorphin; Enkephalin, Leucine; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord | 1990 |
Opioid agonist affinity in the guinea-pig ileum and mouse vas deferens.
Topics: Animals; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Guinea Pigs; Ileum; Male; Methadone; Mice; Morphine; Morphine Derivatives; Naltrexone; Receptors, Opioid; Vas Deferens | 1990 |
Nicotine protects against mu-opioid receptor antagonism by beta-funaltrexamine: evidence for nicotine-induced release of endogenous opioids in brain.
Topics: Analgesia; Animals; Brain; Endorphins; Injections, Intraventricular; Male; Morphine; Naltrexone; Nicotine; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu | 1990 |
"Paradoxical" analgesia and aggravated morphine dependence induced by opioid antagonists.
Topics: Animals; Body Weight; Indoles; Male; Morphinans; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome; Substance-Related Disorders | 1990 |
Further evidence for the implication of a kappa-opioid receptor mechanism in the production of psychological stress-induced analgesia.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics; Animals; Benzomorphans; Drug Tolerance; Electroshock; Indoles; Male; Mice; Mice, Inbred Strains; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Stress, Psychological; Swimming | 1990 |
Antinociceptive effects of [D-Ala2]deltorphin II, a highly selective delta agonist in vivo.
Topics: Analgesics; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Injections, Intraventricular; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Narcotic Antagonists; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta | 1990 |
Perinatal opiate treatment delays growth of cortical dendrites.
Topics: Animals; Animals, Newborn; Dendrites; Female; Male; Morphine; Naltrexone; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred Strains; Receptors, Opioid; Somatosensory Cortex | 1990 |
Morphine promotes the growth of HIV-1 in human peripheral blood mononuclear cell cocultures.
Topics: Cells, Cultured; Gene Products, gag; HIV Core Protein p24; HIV-1; Humans; Leukocytes, Mononuclear; Lymphocyte Activation; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Viral Core Proteins | 1990 |
Hepatobiliary effects of morphine are mediated in the brain.
Topics: Animals; Biliary Tract; Brain; Female; Injections, Intraperitoneal; Injections, Intravenous; Injections, Intraventricular; Injections, Subcutaneous; Liver; Male; Mice; Morphine; Naloxone; Naltrexone; Receptors, Opioid; Sulfobromophthalein | 1990 |
Assessment of relative intrinsic activity of mu-opioid analgesics in vivo by using beta-funaltrexamine.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Fentanyl; Levorphanol; Male; Methadone; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Time Factors | 1990 |
In vivo and in vitro investigation of naltrindole, a delta-opioid antagonist.
Topics: Animals; Dose-Response Relationship, Drug; Electric Stimulation; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Indoles; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphinans; Morphine; Muscle Contraction; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Reaction Time; Receptors, Opioid; Receptors, Opioid, delta; Vas Deferens | 1990 |
Simultaneous development of opioid tolerance and opioid antagonist-induced receptor upregulation.
Topics: Analgesia; Animals; Brain; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Kinetics; Male; Mice; Morphine; Naloxone; Naltrexone; Pain; Receptors, Opioid; Reference Values; Up-Regulation | 1990 |
Pharmacokinetics of morphine and its surrogates. XI: Effect of simultaneously administered naltrexone and morphine on the pharmacokinetics and pharmacodynamics of each in the dog.
Topics: Animals; Bile; Dogs; Half-Life; Morphine; Morphine Derivatives; Naltrexone; Pupil | 1990 |
Suppressive effects of morphine pellet implants on in vivo parameters of immune function.
Topics: Animals; Drug Implants; Hypersensitivity, Delayed; Hypothalamo-Hypophyseal System; Immunosuppressive Agents; Lymphocyte Activation; Male; Mice; Mice, Inbred C3H; Morphine; Naltrexone; Pituitary-Adrenal System; Spleen | 1990 |
Augmentation of morphine-induced changes in brain monoamine metabolism after chronic naltrexone treatment.
Topics: Animals; Brain; Brain Chemistry; Dopamine; Male; Morphine; Naltrexone; Norepinephrine; Rats; Rats, Inbred Strains; Serotonin | 1990 |
Context-specific morphine withdrawal in rats: duration and effects of clonidine.
Topics: Animals; Arousal; Association Learning; Clonidine; Male; Morphine; Morphine Dependence; Motor Activity; Naltrexone; Rats; Social Environment; Substance Withdrawal Syndrome; Weight Loss | 1990 |
[D-Pen2, D-Pen5]enkephalin, the standard delta opioid agonist, induces morphine-like behaviors in mice.
Topics: Analgesics; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Motor Activity; Muscle Tonus; Naloxone; Naltrexone; Narcotic Antagonists; Stereotyped Behavior | 1990 |
Antitussive effects of two specific kappa-opioid agonists, U-50,488H and U-62,066E, in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Antitussive Agents; Cisterna Magna; Cough; Injections; Ketanserin; Male; Methysergide; Morphine; Naloxone; Naltrexone; Pyrrolidines; Rats; Rats, Inbred Strains; Reflex | 1990 |
Opiates suppress carrageenan-induced edema and hyperthermia at doses that inhibit hyperalgesia.
Topics: Analgesics; Animals; Body Temperature; Carrageenan; Dextrorphan; Dose-Response Relationship, Drug; Edema; Levorphanol; Male; Morphine; Naltrexone; Narcotics; Pain; Rats; Rats, Inbred Strains; Stereoisomerism | 1990 |
Antagonism of the acute pharmacological actions of morphine by panax ginseng extract.
Topics: Analgesia; Animals; Body Temperature; Colon; Drugs, Chinese Herbal; Fever; Male; Morphine; Naltrexone; Pain Measurement; Panax; Plants, Medicinal; Rats; Rats, Inbred Strains | 1990 |
Pharmacological regulation of striatal prodynorphin peptides.
Topics: Amphetamine; Animals; Corpus Striatum; Drug Interactions; Enkephalins; Haloperidol; Male; Morphine; Naltrexone; Protein Precursors; Rats; Rats, Inbred Strains; Substantia Nigra | 1990 |
Effects of the enkephalinase inhibitor SCH 34826 on the sleep-waking cycle and EEG activity in the rat.
Topics: Animals; Dioxolanes; Dioxoles; Dipeptides; Dose-Response Relationship, Drug; Electroencephalography; Male; Morphine; Naltrexone; Neprilysin; Rats; Rats, Inbred Strains; Sleep; Sleep, REM; Thiorphan; Wakefulness | 1990 |
Peripheral and central opioid activity in the analgesic potency of morphine.
Topics: Analgesics; Animals; Histamine; Injections, Intraperitoneal; Injections, Intraventricular; Male; Methylhistidines; Morphine; Naltrexone; Rats; Rats, Inbred Strains; Reaction Time | 1990 |
Enhanced sensitivity to behavioral effects of naltrexone in rats.
Topics: Animals; Conditioning, Psychological; Cyclazocine; Dose-Response Relationship, Drug; Ethylketocyclazocine; Male; Morphine; Naloxone; Naltrexone; Rats; Salivation | 1990 |
Action of naloxone on myenteric neurons removed from morphine-treated guinea pigs.
Topics: Acetylcholine; Action Potentials; Animals; Endorphins; Guinea Pigs; Ileum; In Vitro Techniques; Magnesium; Morphine; Muscle Contraction; Myenteric Plexus; Naloxone; Naltrexone; Substance P | 1988 |
Suppression of natural killer cell activity by high-dose narcotic anesthesia in rats.
Topics: Anesthesia; Cytotoxicity Tests, Immunologic; Dose-Response Relationship, Drug; Fentanyl; Interferons; Killer Cells, Natural; Morphine; Naltrexone; Sufentanil; Time Factors | 1989 |
Simultaneous extraction and chromatographic analysis of morphine, dilaudid, naltrexone and naloxone in biological fluids by high-performance liquid chromatography with electrochemical detection.
Topics: Animals; Chromatography, High Pressure Liquid; Electrochemistry; Hydromorphone; Male; Morphine; Naloxone; Naltrexone; Rats | 1989 |
Phosphodiesterase inhibitors potentiate opiate-antagonist discrimination by morphine-dependent rats.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Body Weight; Discrimination, Psychological; Dose-Response Relationship, Drug; Drug Synergism; Male; Morphine; Naltrexone; Narcotic Antagonists; Papaverine; Phosphodiesterase Inhibitors; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome; Substance-Related Disorders | 1989 |
Effects of prior saline-morphine discrimination by pigeons on three-way discrimination including two morphine doses.
Topics: Animals; Columbidae; Dextroamphetamine; Discrimination, Psychological; Dose-Response Relationship, Drug; Morphine; Naltrexone | 1989 |
Down-regulation of proopiomelanocortin synthesis and beta-endorphin utilization in hypothalamus of morphine-tolerant rats.
Topics: Animals; beta-Endorphin; Corpus Striatum; Drug Tolerance; Enkephalin, Methionine; Enkephalins; Hypothalamus; Male; Morphine; Naltrexone; Pro-Opiomelanocortin; Protein Precursors; Rats; Rats, Inbred Strains; Reference Values; RNA, Messenger; Substance Withdrawal Syndrome | 1989 |
Analgesia produced by normal doses of opioid antagonists alone and in combination with morphine.
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Female; Mice; Mice, Inbred BALB C; Morphine; Naloxone; Naltrexone; Pain Measurement; Receptors, Opioid | 1989 |
Effects of kappa opioids on schedule-controlled behavior of squirrel monkeys.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzomorphans; Conditioning, Psychological; Dose-Response Relationship, Drug; Electroshock; Male; Morphinans; Morphine; Naltrexone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Saimiri | 1989 |
Conditioned opioid release in ten-day-old rats.
Topics: Animals; Arousal; Association Learning; Brain; Conditioning, Classical; Endorphins; Female; Learning; Male; Morphine; Naltrexone; Nociceptors; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Opioid; Smell; Synaptic Transmission | 1989 |
Chronic administration of morphine and naltrexone up-regulate mu-opioid binding sites labeled by [3H][D-Ala2,MePhe4,Gly-ol5]enkephalin: further evidence for two mu-binding sites.
Topics: Animals; Benzomorphans; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; In Vitro Techniques; Male; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1989 |
Novelty-induced place preference behavior in rats: effects of opiate and dopaminergic drugs.
Topics: Amphetamines; Animals; Dose-Response Relationship, Drug; Exploratory Behavior; Haloperidol; Male; Morphine; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Opioid | 1989 |
Involvement of opioid and dopaminergic systems in isolation-induced pinning and social grooming of young rats.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Endorphins; Grooming; Haloperidol; Male; Morphine; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Opioid; Social Behavior; Social Isolation | 1989 |
Procedures that produce context-specific tolerance to morphine in rats also produce context-specific withdrawal.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Drug Tolerance; Male; Morphine; Morphine Dependence; Naltrexone; Nociceptors; Rats; Rats, Inbred Strains; Receptors, Opioid; Social Environment; Substance Withdrawal Syndrome; Thermosensing | 1989 |
Pharmacological characterization of supersensitivity to naltrexone in squirrel monkeys.
Topics: Animals; Azocines; Behavior, Animal; Benzomorphans; Diprenorphine; Drug Administration Schedule; Morphine; Naloxone; Naltrexone; Receptors, Opioid; Saimiri | 1989 |
Discriminative stimulus effects of naltrexone in morphine-treated rhesus monkeys.
Topics: Animals; Discrimination Learning; Dose-Response Relationship, Drug; Female; Macaca mulatta; Morphine; Naltrexone; Receptors, Opioid; Substance Withdrawal Syndrome | 1989 |
Effects of opioid receptor antagonists on morphine-induced stupor in rabbits.
Topics: Animals; Coma; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rabbits; Receptors, Opioid | 1989 |
Effects of chronic morphine administration on the mu and delta opioid responses in the CA1 region of the rat hippocampus.
Topics: Animals; Drug Tolerance; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hippocampus; In Vitro Techniques; Male; Morphine; Naltrexone; Phosphorylation; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1989 |
Identification of morphine- and cyclic AMP-regulated phosphoproteins (MARPPs) in the locus coeruleus and other regions of rat brain: regulation by acute and chronic morphine.
Topics: Animals; Brain; Colforsin; Cyclic AMP; Locus Coeruleus; Male; Morphine; Naltrexone; Phosphoproteins; Phosphorylation; Protein Kinases; Proteins; Rats; Rats, Inbred Strains; Time Factors | 1989 |
Kappa opioid receptors of human placental villi modulate acetylcholine release.
Topics: Acetylcholine; Chorionic Villi; Diltiazem; Female; Humans; In Vitro Techniques; Kinetics; Morphine; Naloxone; Naltrexone; Pregnancy; Receptors, Opioid; Receptors, Opioid, kappa | 1989 |
Chronic opioid antagonist treatment: assessment of receptor upregulation.
Topics: Animals; Binding, Competitive; Brain Chemistry; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Kinetics; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Up-Regulation | 1989 |
Site-directed affinity ligands as tools to study the phenomenology and mechanisms of morphine-induced upregulation of opioid receptors.
Topics: Animals; Brain; Morphine; Naltrexone; Rats; Receptors, Opioid; Receptors, Opioid, delta; Synaptic Membranes; Up-Regulation | 1989 |
Evaluation of delta receptor mediation of supraspinal opioid analgesia by in vivo protection against the beta-funaltrexamine antagonist effect.
Topics: Analgesics, Opioid; Animals; Brain Chemistry; Dihydromorphine; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; In Vitro Techniques; Injections, Intraventricular; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Pain Measurement; Receptors, Opioid; Receptors, Opioid, delta | 1989 |
Effects of opioid agonists on urine production in neonatal rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Animals, Newborn; Benzodiazepines; Body Weight; Female; Male; Morphine; Naltrexone; Narcotics; Phentolamine; Pyrrolidines; Rats; Rats, Inbred Strains; Urodynamics | 1989 |
The antinociceptive effects of 3,4-methylenedioxymethamphetamine (MDMA) in the rat.
Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Analgesics; Animals; Dose-Response Relationship, Drug; Male; Methysergide; Morphine; N-Methyl-3,4-methylenedioxyamphetamine; Naltrexone; Pain; Rats; Rats, Inbred Strains; Receptors, Serotonin | 1989 |
Naltrexone blocks nicotine-induced prolactin release.
Topics: Animals; Catheterization; Male; Mecamylamine; Morphine; Naltrexone; Nicotine; Prolactin; Rats; Rats, Inbred Strains | 1989 |
Withdrawal-induced activation of locus coeruleus neurons in opiate-dependent rats: attenuation by lesions of the nucleus paragigantocellularis.
Topics: Action Potentials; Animals; Kynurenic Acid; Locus Coeruleus; Male; Medulla Oblongata; Morphine; Naltrexone; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome | 1989 |
Naltrexone discrimination in morphine-treated monkeys.
Topics: Animals; Avoidance Learning; Discrimination Learning; Dose-Response Relationship, Drug; Injections, Subcutaneous; Macaca mulatta; Morphine; Naltrexone | 1989 |
Intracerebroventricular N-ethylmaleimide differentially reduces supraspinal opioid analgesia in mice.
Topics: Analgesics; Animals; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylmaleimide; Injections, Intraventricular; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Sulfhydryl Reagents | 1989 |
Studies on the mechanism of hypoglycemia induced by intrathecal morphine: dissociation from behavioral effects, effects of tolerance and depletion of liver glycogen.
Topics: Animals; Behavior, Animal; Drug Interactions; Drug Tolerance; Female; Hypoglycemia; Injections, Spinal; Liver; Liver Glycogen; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Pentobarbital; Rats; Rats, Inbred Strains; Species Specificity; Strychnine | 1989 |
Locus ceruleus discharge characteristics of morphine-dependent rats: effects of naltrexone.
Topics: Action Potentials; Animals; Locus Coeruleus; Male; Morphine; Naltrexone; Rats; Rats, Inbred Strains; Substance-Related Disorders | 1989 |
Delayed suppression of serum luteinizing hormone after naloxone treatment in neonatal female rats.
Topics: Animals; Animals, Newborn; Female; Luteinizing Hormone; Morphine; Naloxone; Naltrexone; Pain; Rats; Rats, Inbred Strains; Secretory Rate; Time Factors | 1989 |
The periaqueductal gray matter mediates opiate-induced immunosuppression.
Topics: Animals; Immune Tolerance; Killer Cells, Natural; Male; Mesencephalon; Microinjections; Morphine; Naltrexone; Rats; Rats, Inbred F344 | 1989 |
Effects of acute morphine administration on noradrenaline turnover and metabolism in various brain parts of control and handled rats.
Topics: Animals; Brain Chemistry; Dose-Response Relationship, Drug; Male; Methoxyhydroxyphenylglycol; Morphine; Naltrexone; Norepinephrine; Rats; Rats, Inbred Strains; Stress, Physiological | 1989 |
Perturbation of glutathione by a central action of morphine.
Topics: Animals; Blood Gas Analysis; Body Temperature; Glutathione; Liver; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Oxidation-Reduction; Oxygen | 1989 |
The tegmental pedunculopontine nucleus: a brain-stem output of the limbic system critical for the conditioned place preferences produced by morphine and amphetamine.
Topics: Amphetamine; Animals; Brain Stem; Conditioning, Psychological; Dose-Response Relationship, Drug; Limbic System; Male; Morphine; Naltrexone; Narcotic Antagonists; Periaqueductal Gray; Pons; Psychotropic Drugs; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Retention, Psychology; Tegmentum Mesencephali | 1989 |
Central vs. peripheral mediation of opioid effects on alcohol consumption in free-feeding rats.
Topics: Alcohol Drinking; Animals; Dose-Response Relationship, Drug; Drinking Behavior; Drug Interactions; Loperamide; Male; Morphine; Naltrexone; Narcotic Antagonists; Piperidines; Polysorbates; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Time Factors | 1989 |
Does the blockade of opioid receptors influence the development of ethanol dependence?
Topics: Alcoholism; Animals; Diprenorphine; Female; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Seizures; Substance Withdrawal Syndrome | 1987 |
Multiple opiate receptors and pharmacological response to morphine in rats maintained on diets differing in protein concentration.
Topics: Analgesics; Animals; Body Temperature; Body Weight; Brain; Dietary Proteins; Drinking; Drug Interactions; Eating; Male; Morphine; Naltrexone; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Opioid | 1987 |
Chronic opioid antagonist treatment facilitates nonopioid, stress-induced analgesia.
Topics: Animals; Cold Temperature; Drug Implants; Male; Morphine; Naltrexone; Pain; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Opioid; Stress, Physiological; Swimming | 1987 |
Effects of beta-funaltrexamine on radiolabeled opioid binding.
Topics: Animals; Binding, Competitive; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; In Vitro Techniques; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu | 1987 |
Evidence for the interaction of morphine with kappa and delta opioid receptors to induce analgesia in beta-funaltrexamine-treated mice.
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa | 1987 |
Opioid delta-receptor involvement in supraspinal and spinal antinociception in mice.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Drug Combinations; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Hot Temperature; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Nociceptors; Pain; Receptors, Opioid; Receptors, Opioid, delta; Spinal Cord | 1987 |
Cellular mechanisms of opioid tolerance: studies in single brain neurons.
Topics: Animals; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; In Vitro Techniques; Locus Coeruleus; Male; Membrane Potentials; Morphine; Morphine Derivatives; Naltrexone; Neurons; Potassium; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu | 1987 |
Peripheral receptors mediate the aversive conditioning effects of morphine in the rat.
Topics: Amphetamine; Animals; Capsaicin; Chlorides; Conditioning, Classical; Injections, Intraperitoneal; Lithium; Lithium Chloride; Male; Morphine; Naltrexone; Peritoneal Cavity; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Receptors, Opioid; Taste | 1987 |
Chronic naltrexone supersensitizes the reinforcing and locomotor-activating effects of morphine.
Topics: Animals; Conditioning, Classical; Drug Synergism; Male; Morphine; Motor Activity; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Reinforcement, Psychology | 1987 |
Chronic morphine upregulates a mu-opiate binding site labeled by [3H]cycloFOXY: a novel opiate antagonist suitable for positron emission tomography.
Topics: Alkylating Agents; Animals; Binding, Competitive; Drug Tolerance; Enkephalin, Leucine; In Vitro Techniques; Male; Morphine; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Tomography, Emission-Computed | 1987 |
Effects of stress and beta-funal trexamine pretreatment on morphine analgesia and opioid binding in rats.
Topics: Analgesia; Animals; Brain; Male; Morphine; Naltrexone; Narcotics; Rats; Rats, Inbred Strains; Receptors, Opioid; Stress, Physiological | 1987 |
Opioid analgesia in the mouse: evidence for multiple receptors using beta-FNA.
Topics: Analgesia; Animals; Enkephalins; Male; Mice; Mice, Inbred Strains; Morphine; Naltrexone; Narcotic Antagonists; Pain; Receptors, Opioid | 1986 |
Potentiation of pentobarbital sleeping time by the acute and chronic administration of morphine.
Topics: Animals; Drug Synergism; Male; Morphine; Naltrexone; Pentobarbital; Rats; Rats, Inbred Strains; Receptors, Opioid; Sleep | 1987 |
Roles of central and peripheral mu, delta and kappa opioid receptors in the mediation of gastric acid secretory effects in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Brain; Cyclazocine; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; Gastric Acid; Male; Morphine; Naltrexone; Pyrrolidines; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1988 |
Binaltorphimine-related bivalent ligands and their kappa opioid receptor antagonist selectivity.
Topics: Animals; Chemical Phenomena; Chemistry; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Male; Mice; Models, Molecular; Morphine; Muscle, Smooth; Naltrexone; Receptors, Opioid; Receptors, Opioid, kappa; Structure-Activity Relationship | 1988 |
Only one pharmacophore is required for the kappa opioid antagonist selectivity of norbinaltorphimine.
Topics: Animals; Chemical Phenomena; Chemistry; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Ileum; Male; Mice; Morphine; Naltrexone; Receptors, Opioid; Receptors, Opioid, kappa; Stereoisomerism; Structure-Activity Relationship; Vas Deferens | 1988 |
Nor-binaltorphimine, a highly selective kappa-opioid antagonist in analgesic and receptor binding assays.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Guinea Pigs; Male; Mice; Morphine; Naltrexone; Oligopeptides; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa | 1988 |
Upregulation of opioid receptor subtypes correlates with potency changes of morphine and DADLE.
Topics: Animals; Brain; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Mice; Morphine; Naltrexone; Pain; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1988 |
Centrally mediated opioid induced depression of hepatic glutathione: effects of intracerebroventricular administration of mu, kappa, sigma and delta agonists.
Topics: Animals; Brain; Circadian Rhythm; Dose-Response Relationship, Drug; Glutathione; Injections, Intraventricular; Liver; Male; Mice; Morphine; Naltrexone; Narcotics; Receptors, Opioid; Time Factors | 1988 |
Central pharmacological activity of a quaternary ammonium compound in streptozotocin diabetic mice.
Topics: Animals; Blood-Brain Barrier; Cell Membrane Permeability; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Female; Injections, Subcutaneous; Insulin; Mice; Morphine; Naltrexone; Narcotic Antagonists; Pharmaceutical Vehicles; Quaternary Ammonium Compounds; Streptozocin | 1988 |
Chronic administration of morphine and naltrexone up-regulate[3H][D-Ala2,D-leu5]enkephalin binding sites by different mechanisms.
Topics: Animals; Drug Tolerance; Male; Morphine; Morphine Dependence; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Sodium Chloride | 1988 |
Suppression by nor-binaltorphimine of kappa opioid-mediated diuresis in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Diuresis; Dose-Response Relationship, Drug; Male; Morphine; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa | 1988 |
Chronic treatment with naltrexone enhances morphine-stimulated dopamine neurotransmission: neurochemical and behavioral evidence.
Topics: Animals; Brain Chemistry; Dihydroxyphenylalanine; Dopamine; Male; Morphine; Motor Activity; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Synaptic Transmission | 1988 |
Opposite effects of mu and kappa opiate agonists on dopamine release in the nucleus accumbens and in the dorsal caudate of freely moving rats.
Topics: Animals; Benzomorphans; Caudate Nucleus; Dopamine; Male; Methadone; Morphine; Motor Activity; Naloxone; Naltrexone; Nucleus Accumbens; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reward; Septal Nuclei | 1988 |
Inhibition by opioid agonists and enhancement by antagonists of the release of catecholamines from the dog adrenal gland in response to splanchnic nerve stimulation: evidence for the functional role of opioid receptors.
Topics: Adrenal Glands; Animals; Catecholamines; Dogs; Electric Stimulation; Enkephalin, Leucine; Female; Male; Morphine; Naloxone; Naltrexone; Receptors, Opioid; Splanchnic Nerves | 1988 |
Analeptic effect of opiate receptor agonists in rabbits.
Topics: Animals; Arousal; Brain; Central Nervous System Stimulants; Codeine; Cyclazocine; Dose-Response Relationship, Drug; Enkephalin, Methionine; Ethylketocyclazocine; Etorphine; Male; Meperidine; Methadone; Morphine; Naltrexone; Narcotics; Phenazocine; Rabbits; Receptors, Opioid; Reflex | 1985 |
Non-dopaminergic mechanisms in the turning behavior evoked by intranigral opiates.
Topics: Animals; Dynorphins; Enkephalins; Hydroxydopamines; Male; Medial Forebrain Bundle; Morphine; Movement; Naltrexone; Neural Pathways; Oxidopamine; Rats; Rats, Inbred Strains; Substantia Nigra | 1985 |
An analysis of naltrexone and naloxone's possible agonistic actions in the dog.
Topics: Analgesics, Opioid; Animals; Cyclazocine; Dogs; Drug Synergism; Electroencephalography; Ethylketocyclazocine; Evoked Potentials; Female; Fentanyl; Morphine; Naloxone; Naltrexone; Reaction Time; Reflex; Reflex, Pupillary | 1985 |
Effect of beta-funaltrexamine on opioid side-effects produced by morphine and U-50, 488H.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Body Temperature; Depression, Chemical; Dose-Response Relationship, Drug; Gastrointestinal Motility; Hypnotics and Sedatives; Male; Morphine; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rats; Rats, Inbred Strains; Respiration | 1985 |
Chronic desipramine attenuates morphine analgesia.
Topics: Analgesics, Opioid; Animals; Desipramine; Drug Interactions; Male; Mice; Morphine; Naloxone; Naltrexone; Propranolol; Reaction Time | 1986 |
[3H]dynorphin A binding and kappa selectivity of prodynorphin peptides in rat, guinea-pig and monkey brain.
Topics: Alkylating Agents; Animals; Benzomorphans; Brain Chemistry; Dynorphins; Guinea Pigs; In Vitro Techniques; Macaca mulatta; Morphine; Naltrexone; Peptides; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stereoisomerism | 1986 |
Binaltorphimine and nor-binaltorphimine, potent and selective kappa-opioid receptor antagonists.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Chemical Phenomena; Chemistry; Cyclazocine; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Male; Mice; Morphine; Naloxone; Naltrexone; Pyrrolidines; Rabbits; Receptors, Opioid; Receptors, Opioid, kappa | 1987 |
An investigation of tolerance to the actions of leptogenic and anorexigenic drugs in mice.
Topics: Amphetamine; Animals; Appetite Depressants; Body Weight; Calcitonin; Dextroamphetamine; Drug Tolerance; Eating; Fluoxetine; Mice; Morphine; Naltrexone; Neurotransmitter Agents | 1987 |
Evidence for a peripheral action of thyrotropin releasing hormone on gastrointestinal transit in mice.
Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Drug Synergism; Gastrointestinal Transit; Loperamide; Male; Mice; Mice, Inbred Strains; Morphine; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Thiazolidines; Thyrotropin-Releasing Hormone | 1988 |
Pharmacological evidence of a central effect of naltrexone, morphine, and beta-endorphin and a peripheral effect of met- and leu-enkephalin on retention of an inhibitory response in mice.
Topics: Adrenal Medulla; Animals; Avoidance Learning; beta-Endorphin; Brain; Drug Interactions; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Male; Memory; Mice; Morphine; Naltrexone; Quaternary Ammonium Compounds; Retention, Psychology | 1985 |
High dose of spinal morphine produce a nonopiate receptor-mediated hyperesthesia: clinical and theoretic implications.
Topics: Anesthesia, Spinal; Animals; Blood Pressure; Cats; Drug Tolerance; Fentanyl; Hyperesthesia; Methadone; Morphine; Morphine Derivatives; Naltrexone; Rats; Receptors, Drug; Stimulation, Chemical; Strychnine; Sufentanil; Sulfates; Touch | 1986 |
The concentration of arginine vasopressin in pituitary stalk plasma of the rat after adrenalectomy or morphine.
Topics: Adrenalectomy; Animals; Arginine Vasopressin; beta-Endorphin; Dexamethasone; Endorphins; Male; Morphine; Naltrexone; Pituitary Gland; Portal System; Rats; Rats, Inbred Strains | 1986 |
Morphine or capsaicin administration alters the secretion of beta-endorphin into the hypophysial portal vasculature of the rat.
Topics: Animals; beta-Endorphin; Capsaicin; Endorphins; Hypophysectomy; Male; Morphine; Naltrexone; Pituitary Gland; Portal System; Radioimmunoassay; Rats; Rats, Inbred Strains | 1986 |
Intrathecal beta-funaltrexamine antagonizes intracerebroventricular beta-endorphin- but not morphine-induced analgesia in mice.
Topics: Analgesia; Animals; beta-Endorphin; Cerebral Ventricles; Dose-Response Relationship, Drug; Injections, Intraventricular; Injections, Spinal; Male; Mice; Models, Neurological; Morphine; Naltrexone; Narcotic Antagonists; Spinal Cord | 1988 |
Comparisons of descending pain inhibitory pathways activated by beta-endorphin and morphine as characterized by supraspinal and spinal antinociceptive interactions in mice.
Topics: Analgesia; Animals; beta-Endorphin; Drug Tolerance; Efferent Pathways; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Pain; Spinal Cord | 1988 |
Neurochemical and functional correlates of naltrexone-induced opiate receptor up-regulation.
Topics: Animals; Brain Chemistry; Guanosine Triphosphate; Male; Morphine; Naloxone; Naltrexone; Pain; Rats; Rats, Inbred Strains; Receptors, Opioid; Time Factors | 1985 |
Opioid receptor binding characteristics of the non-equilibrium mu antagonist, beta-funaltrexamine (beta-FNA).
Topics: Animals; Brain; Enkephalin, Methionine; In Vitro Techniques; Ligands; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tritium | 1985 |
Effects of 5,5'-dithiobis-(2-nitrobenzoic acid) on opiate binding to both the membrane-bound receptor and the partially purified opiate receptor.
Topics: Animals; Butorphanol; Cell Membrane; Dihydromorphine; Diprenorphine; Dithionitrobenzoic Acid; Dithiothreitol; Etorphine; Morphine; Nalorphine; Naloxone; Naltrexone; Nitrobenzoates; Oxymorphone; Rats; Receptors, Opioid | 1985 |
Plasma corticosterone changes in response to central or peripheral administration of kappa and sigma opiate agonists.
Topics: Animals; Brain; Corticosterone; Cyclazocine; Ethylketocyclazocine; Humans; Hypothalamo-Hypophyseal System; Male; Morphine; Naloxone; Naltrexone; Opioid-Related Disorders; Phenazocine; Pituitary-Adrenal System; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, sigma | 1985 |
Increased analgesic potency of morphine and increased brain opioid binding sites in the rat following chronic naltrexone treatment.
Topics: Animals; Binding, Competitive; Brain; Drug Implants; Drug Interactions; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Morphine; Naloxone; Naltrexone; Pain; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Opioid; Time Factors | 1985 |
Opiate antagonism reduces placentophagia and pup cleaning by parturient rats.
Topics: Animals; Drug Tolerance; Feeding Behavior; Female; Labor, Obstetric; Maternal Behavior; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Placenta; Pregnancy; Rats; Rats, Inbred Strains; Receptors, Opioid; Time Factors | 1985 |
Changes in responsiveness to mu and kappa opiates following a series of convulsions.
Topics: Animals; Codeine; Dose-Response Relationship, Drug; Electroshock; Levorphanol; Mice; Mice, Inbred C57BL; Morphine; Naltrexone; Narcotics; Receptors, Opioid; Seizures | 1985 |
Differential effects of morphine on the rates of dopamine turnover in the neural and intermediate lobes of the rat pituitary gland.
Topics: alpha-Methyltyrosine; Animals; Dopamine; Kinetics; Male; Median Eminence; Methyltyrosines; Morphine; Naltrexone; Pituitary Gland; Pituitary Gland, Posterior; Rats; Receptors, Opioid | 1985 |
Effect of mu and kappa opioid receptor agonists on rat plasma corticosterone levels.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Benzomorphans; Corticosterone; Dose-Response Relationship, Drug; Fentanyl; Male; Morphine; Naloxone; Naltrexone; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1985 |
Characterization of the discriminative stimulus effects of centrally administered morphine in the rat.
Topics: Animals; Discrimination Learning; Injections, Intraventricular; Injections, Subcutaneous; Male; Morphine; Naltrexone; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Receptors, Opioid | 1985 |
N-(3-Fluoropropyl)-N-normetazocine, a potentially useful opiate antagonist for opiate receptor studies with positron emission tomography (PET).
Topics: Analgesics; Animals; Binding, Competitive; Brain; Cyclazocine; Guinea Pigs; In Vitro Techniques; Male; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Structure-Activity Relationship; Tomography, Emission-Computed | 1985 |
A radiolabeled-ligand-binding technique for the characterization of opioid receptors in the intact mouse vas deferens.
Topics: Animals; Binding, Competitive; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; In Vitro Techniques; Kinetics; Male; Mice; Morphine; Naltrexone; Radioligand Assay; Receptors, Opioid; Vas Deferens | 1985 |
Pharmacological evidence for a protective role of the endogenous opioid system on electroshock-induced seizures in the mouse.
Topics: Animals; Electroshock; Endorphins; Injections, Intraperitoneal; Male; Mice; Mice, Inbred C57BL; Morphine; Naloxone; Naltrexone; Receptors, Opioid; Seizures; Time Factors | 1985 |
Inhibition of luteinizing hormone release by morphine and endogenous opiates in cultured pituitary cells.
Topics: Animals; beta-Endorphin; Cells, Cultured; Endorphins; Etorphine; Female; Gonadotropin-Releasing Hormone; Immunologic Techniques; Luteinizing Hormone; Morphine; Naltrexone; Pituitary Gland, Anterior; Rats; Receptors, Cell Surface; Receptors, LHRH; Receptors, Opioid | 1986 |
An assessment of the role of opioid receptors in the response to cannabimimetic drugs.
Topics: Adenylyl Cyclase Inhibitors; Animals; Cannabinoids; Cell Line; Dronabinol; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Etorphine; Morphine; Naltrexone; Neuroblastoma; Neurons; Receptors, Opioid; Receptors, Opioid, delta | 1986 |
Investigation of the structural requirements for the kappa-selective opioid receptor antagonist, 6 beta,6 beta'-[ethylenebis(oxyethyleneimino)]bis[17-(cyclopropylmethyl)- 4,5 alpha-epoxymorphinan-3,14-diol] (TENA).
Topics: Animals; Electric Stimulation; Guinea Pigs; Ileum; Morphine; Naltrexone; Receptors, Opioid; Structure-Activity Relationship | 1986 |
Effects of endogenous and exogenous opioids on splenic natural killer cell activity.
Topics: Adrenocorticotropic Hormone; Animals; beta-Endorphin; Cytotoxicity Tests, Immunologic; Electric Stimulation; Endorphins; Female; Injections, Intraperitoneal; Killer Cells, Natural; Male; Mice; Mice, Inbred Strains; Morphine; Naloxone; Naltrexone; Poly I-C; Spleen | 1986 |
Behavioral effects of opioid peptides selective for mu or delta receptors. I. Morphine-like discriminative stimulus effects.
Topics: Animals; beta-Endorphin; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Discrimination Learning; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Morphine; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1986 |
Synthesis and opioid antagonist potencies of naltrexamine bivalent ligands with conformationally restricted spacers.
Topics: Animals; Biological Assay; Chemical Phenomena; Chemistry; Cyclazocine; Endorphins; Ethylketocyclazocine; Guinea Pigs; Ileum; Molecular Conformation; Morphine; Muscle Contraction; Naltrexone; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship | 1986 |
Involvement of brain opiate receptors in the immune-suppressive effect of morphine.
Topics: Animals; Brain; Cytotoxicity, Immunologic; Immunosuppressive Agents; Killer Cells, Natural; Male; Morphine; Naltrexone; Rats; Rats, Inbred F344; Receptors, Opioid | 1986 |
beta-Funaltrexamine (beta-FNA) and the regulation of body and brain development in rats.
Topics: Animals; Body Weight; Brain; Cerebellum; Female; Male; Morphine; Naltrexone; Nociceptors; Rats; Rats, Inbred Strains; Receptors, Opioid | 1986 |
Pharmacodynamic supersensitivity and opioid receptor upregulation in the mouse.
Topics: Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Lethal Dose 50; Male; Mice; Morphine; Naltrexone; Receptors, Opioid; Time Factors | 1986 |
Irreversible blockage of opioid receptor types by ester homologues of beta-funaltrexamine.
Topics: Animals; Dihydromorphine; In Vitro Techniques; Morphine; Naltrexone; Narcotic Antagonists; Rats; Receptors, Opioid; Receptors, Opioid, mu; Structure-Activity Relationship | 1986 |
Effects of the affinity ligands 14-beta-chloroacetylnaltrexone and 14-beta-bromoacetamidomorphine on [3H]-dihydromorphine binding sites in rat brain.
Topics: Animals; Brain; Dihydromorphine; In Vitro Techniques; Ligands; Male; Morphine; Morphine Derivatives; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Tritium | 1986 |
Use of beta-funaltrexamine to determine mu opioid receptor involvement in the analgesic activity of various opioid ligands.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Biological Assay; Buprenorphine; Butorphanol; Cyclazocine; Dose-Response Relationship, Drug; Ethylketocyclazocine; Etorphine; Fentanyl; Methadone; Mice; Morphine; Muscle Contraction; Nalbuphine; Nalorphine; Naltrexone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, mu | 1987 |
Naltrexone reverses a long term depressive effect of a toxic lithium injection on saccharin preference.
Topics: Animals; Chlorides; Female; Lithium; Lithium Chloride; Morphine; Naltrexone; Rats; Rats, Inbred Strains; Saccharin; Taste | 1987 |
Multiple interconvertible affinity states for the delta opioid agonist-receptor complex.
Topics: Animals; Cattle; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylmaleimide; Guanylyl Imidodiphosphate; Hippocampus; Kinetics; Morphine; Naltrexone; Receptors, Opioid; Receptors, Opioid, delta; Synaptic Membranes | 1987 |
Effects of restraint and naltrexone on the biphasic heart rate response to morphine in rats.
Topics: Animals; Bradycardia; Heart Rate; Male; Morphine; Naltrexone; Rats; Receptors, Opioid; Restraint, Physical; Tachycardia; Time Factors | 1987 |
An analysis of the paradoxical effect of morphine on runway speed and food consumption.
Topics: Animals; Avoidance Learning; Feeding Behavior; Food Deprivation; Male; Morphine; Motivation; Naltrexone; Nervous System; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Reward; Taste; Tegmentum Mesencephali | 1986 |
Beta-funaltrexamine antagonizes the discriminative stimulus effects of morphine but not naltrexone in pigeons.
Topics: Animals; Columbidae; Discrimination, Psychological; Dose-Response Relationship, Drug; Morphine; Naltrexone | 1987 |
Analgesia and decrement in operant performance in socially defeated mice: selective cross-tolerance to morphine and antagonism by naltrexone.
Topics: Aggression; Analgesia; Animals; Conditioning, Operant; Drug Tolerance; Male; Mice; Mice, Inbred Strains; Morphine; Naltrexone; Reaction Time; Reinforcement Schedule; Social Behavior | 1987 |
Morphine induces delayed anorexia in rats.
Topics: Animals; Feeding Behavior; Gastrointestinal Contents; Male; Morphine; Naltrexone; Organ Size; Rats; Time Factors | 1988 |
Dissociation of the opioid and nonopioid effects of cyclazocine.
Topics: Animals; Cyclazocine; Dose-Response Relationship, Drug; Electroencephalography; Female; Hallucinogens; Morphine; Morphine Dependence; Naltrexone; Narcotics; Rats; Rats, Inbred Strains; Stereoisomerism | 1988 |
Stress- and morphine-induced elevations of plasma and tissue cholesterol in mice: reversal by naltrexone.
Topics: Animals; Aorta; Cholesterol; Female; Liver; Loperamide; Mice; Morphine; Naltrexone; Receptors, LDL; Stress, Physiological | 1988 |
Behavioral evidence for cholecystokinin-opiate interactions in neonatal rats.
Topics: Animals; Animals, Newborn; Cholecystokinin; Drug Interactions; Morphine; Motor Activity; Naltrexone; Pain; Rats; Rats, Inbred Strains; Reference Values; Sincalide; Stress, Psychological; Vocalization, Animal | 1988 |
Clonidine activates a cholinergic hippocampal theta rhythm in the rat.
Topics: Animals; Clonidine; Electroencephalography; Hippocampus; Male; Morphine; Naltrexone; Rats; Rats, Inbred Strains; Reference Values; Scopolamine; Theta Rhythm; Yohimbine | 1988 |
Morphine preexposure attenuates the aversive properties of opiates without preexposure to the aversive properties.
Topics: Animals; Conditioning, Psychological; Male; Morphine; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Reference Values; Saccharin; Taste | 1988 |
Comparison of the oxytocin response to water-deprivation, hyperosmolarity and administration of morphine or naltrexone in lactating and virgin female rats.
Topics: Animals; Female; Lactation; Morphine; Naltrexone; Oxytocin; Pregnancy; Rats; Reference Values; Saline Solution, Hypertonic; Water Deprivation | 1988 |
Morphine effects on locus ceruleus neurons are dependent on the state of arousal and availability of external stimuli: studies in anesthetized and unanesthetized rats.
Topics: Anesthesia; Animals; Arousal; Electric Stimulation; Locus Coeruleus; Male; Morphine; Naltrexone; Rats; Rats, Inbred Strains | 1988 |
Neonatal naltrexone treatment: effects on sexual and exploratory behavior in male and female rats.
Topics: Animals; Animals, Newborn; Copulation; Exploratory Behavior; Female; Male; Morphine; Naltrexone; Posture; Rats; Sex Factors; Sexual Behavior, Animal | 1988 |
Kappa opioids in rhesus monkeys. II. Analysis of the antagonistic actions of quadazocine and beta-funaltrexamine.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Azocines; Benzomorphans; Cyclazocine; Diuresis; Endorphins; Ethylketocyclazocine; Female; Hot Temperature; Macaca mulatta; Male; Morphine; Naltrexone; Narcotic Antagonists; Pyrrolidines; Reaction Time; Tail | 1987 |
Evidence for the delivery of narcotic antagonists to the colon as their glucuronide conjugates.
Topics: Animals; Colon; Constipation; Diarrhea; Dose-Response Relationship, Drug; Glucuronates; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Skin Temperature; Substance-Related Disorders | 1988 |
Differential antagonism by naltrexone of the effects of opioids on a fixed-ratio discrimination in rats.
Topics: Animals; Conditioning, Operant; Cyclazocine; Discrimination Learning; Dose-Response Relationship, Drug; Ethylketocyclazocine; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Pentazocine; Rats | 1988 |
Pharmacology of the allodynia in rats evoked by high dose intrathecal morphine.
Topics: Analgesia; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Injections, Spinal; Morphine; Naltrexone; Pain; Rats; Spinal Cord; Structure-Activity Relationship; Strychnine | 1988 |
Acute supersensitivity to the discriminative stimulus effects of naltrexone in pigeons.
Topics: Animals; Binding Sites; Columbidae; Diprenorphine; Discrimination Learning; Dose-Response Relationship, Drug; Generalization, Stimulus; Morphine; Nalorphine; Naloxone; Naltrexone; Opioid-Related Disorders | 1988 |
Protection by opioids against gastric lesions caused by necrotizing agents.
Topics: Animals; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Endorphins; Gastric Mucosa; Hydrochloric Acid; Male; Morphine; Naltrexone; Rats; Rats, Inbred Strains; Sodium Hydroxide; Stomach Ulcer | 1988 |
Effect of morphine and nalmefene on energy balance in diabetic and non-diabetic rats.
Topics: Animals; Body Weight; Diabetes Mellitus, Experimental; Eating; Energy Metabolism; Male; Morphine; Naltrexone; Rats; Rats, Inbred Strains | 1988 |
Comparative evaluation of different pathways for the liver toxicity of morphine using freshly isolated hepatocytes.
Topics: Animals; Glutathione; Liver; Male; Metyrapone; Morphine; Naloxone; Naltrexone; Rats; Rats, Inbred Strains | 1988 |
Irreversible binding of [3H]beta-funaltrexamine to brain slices of morphine-tolerant and -dependent mice.
Topics: Animals; Brain Chemistry; Corpus Striatum; Drug Tolerance; In Vitro Techniques; Male; Mesencephalon; Mice; Morphine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Stereoisomerism | 1988 |
Evidence for the involvement of central opioidergic systems in L-tyrosine methyl ester-induced analgesia in the rat.
Topics: Analgesia; Animals; Endorphins; Injections, Intraventricular; Injections, Subcutaneous; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Tyrosine | 1988 |
Chronic antagonist infusion does not increase morphine antinociception in rat spinal cord.
Topics: Animals; Injections, Spinal; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Rats; Rats, Inbred Strains; Spinal Cord | 1987 |
Effects of a single administration of morphine or footshock stress on natural killer cell cytotoxicity.
Topics: Animals; Cytotoxicity, Immunologic; Electroshock; Female; Immunosuppression Therapy; Killer Cells, Natural; Morphine; Naltrexone; Rats; Rats, Inbred F344; Spleen; Stress, Physiological | 1987 |
Endogenous opioids and post-ictal increase in seizure threshold in Mongolian gerbils.
Topics: Animals; Electric Stimulation; Endorphins; Gerbillinae; Morphine; Naloxone; Naltrexone; Pentylenetetrazole; Seizures | 1987 |
Variable-interval schedules of timeout from avoidance: effects of chlordiazepoxide, CGS 8216, morphine, and naltrexone.
Topics: Animals; Avoidance Learning; Chlordiazepoxide; Conditioning, Operant; Male; Morphine; Naltrexone; Pyrazoles; Rats; Rats, Inbred Strains; Reinforcement Schedule | 1987 |
Sensitization to repeated morphine injection in the rat: possible involvement of A10 dopamine neurons.
Topics: Animals; Dopamine; Male; Morphine; Motor Activity; Naltrexone; Neurons; Nucleus Accumbens; Rats; Rats, Inbred Strains; Tegmentum Mesencephali; Tissue Distribution | 1987 |
[Effects of the opiate antagonists naloxone and naltrexone on the body temperature of rats].
Topics: Animals; Body Temperature; Dose-Response Relationship, Drug; Drug Interactions; Male; Morphine; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Time Factors | 1987 |
Comparison of naltrexone and quaternary naltrexone after systemic and intracerebroventricular administration in pigeons.
Topics: Animals; Columbidae; Discrimination Learning; Injections, Intramuscular; Injections, Intraventricular; Morphine; Naltrexone; Quaternary Ammonium Compounds; Reinforcement Schedule | 1987 |
Morphine, saline and naltrexone discrimination in morphine-treated pigeons.
Topics: Animals; Columbidae; Discrimination Learning; Dose-Response Relationship, Drug; Drug Interactions; Morphine; Naltrexone; Sodium Chloride | 1987 |
Nitrous oxide-induced hypothermia in the rat.
Topics: Animals; Body Temperature; Chloral Hydrate; Dose-Response Relationship, Drug; Drug Tolerance; Kinetics; Male; Morphine; Naloxone; Naltrexone; Nitrous Oxide; Rats | 1987 |
The role of endogenous opioids in footshock-induced hyperthermia.
Topics: Animals; Body Temperature Regulation; Drug Tolerance; Electroshock; Endorphins; Fever; Male; Morphine; Naltrexone; Rats; Rats, Inbred Strains; Stress, Physiological | 1987 |
Antagonism by nalmefene of systemic and intrathecal morphine-induced analgesia in mice.
Topics: Analgesia; Animals; Injections, Intravenous; Injections, Spinal; Male; Mice; Morphine; Naloxone; Naltrexone; Time Factors | 1987 |
Is the motivational effect of opiate withdrawal reflected by common somatic indices of precipitated withdrawal? A place conditioning study in the rat.
Topics: Animals; Avoidance Learning; Behavior, Animal; Body Weight; Dose-Response Relationship, Drug; Drug Implants; Male; Morphine; Motivation; Naltrexone; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome | 1987 |
Evidence for a central but not adrenal, opioid mediation in hypertension induced by brief isolation in the rat.
Topics: Adrenalectomy; Animals; Blood Pressure; Corticosterone; Endorphins; Gastrointestinal Motility; Male; Morphine; Nalorphine; Naloxone; Naltrexone; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Social Isolation; Stress, Physiological | 1986 |
Opioid-mediation of separation distress in 10-day-old rats: reversal of stress with maternal stimuli.
Topics: Animals; Animals, Newborn; Brain; Endorphins; Female; Maternal Deprivation; Morphine; Naltrexone; Pain; Rats; Rats, Inbred Strains; Social Isolation; Vocalization, Animal | 1986 |
Comparison of the effects of morphine and immobilization stress on discrimination performance of rats.
Topics: Animals; Arousal; Attention; Conditioning, Operant; Discrimination, Psychological; Electroshock; Male; Morphine; Naloxone; Naltrexone; Orientation; Psychomotor Performance; Rats; Rats, Inbred Strains; Restraint, Physical; Stress, Psychological | 1986 |
Effect of morphine treatment and withdrawal on endogenous methionine- and leucine-enkephalin levels in primate brain.
Topics: Animals; Brain Chemistry; Chlorocebus aethiops; Enkephalin, Leucine; Enkephalin, Methionine; Female; Male; Morphine; Naltrexone; Substance Withdrawal Syndrome | 1986 |
Pharmacologic and reinforcing properties of phencyclidine and the enantiomers of N-allylnormetazocine in the dog.
Topics: Animals; Behavior, Animal; Conditioning, Operant; Decerebrate State; Dogs; Female; Morphine; Naltrexone; Phenazocine; Phencyclidine; Reinforcement Schedule; Self Administration; Stereoisomerism | 1986 |
Loss of estradiol-positive feedback action on LH release during prepubertal period in rats treated postnatally with an opiate antagonist.
Topics: Animals; Brain; Endorphins; Estradiol; Female; Luteinizing Hormone; Male; Morphine; Naltrexone; Orchiectomy; Ovariectomy; Rats; Rats, Inbred Strains; Sex Characteristics | 1986 |
Ingestion of amniotic fluid enhances opiate analgesia in rats.
Topics: Amniotic Fluid; Analgesia; Animals; Endorphins; Female; Labor, Obstetric; Morphine; Naltrexone; Placenta; Pregnancy; Rats | 1986 |
[Naloxone and naltrexone antagonism of various central effects of morphine].
Topics: Animals; Behavior, Animal; Central Nervous System; Female; Male; Mice; Morphine; Naloxone; Naltrexone; Pain Measurement; Rats; Substance Withdrawal Syndrome | 1986 |
Antinociceptive models displaying peripheral opioid activity.
Topics: Analgesics; Animals; Carrageenan; Codeine; Dextropropoxyphene; Dose-Response Relationship, Drug; Epoprostenol; Female; Indomethacin; Mice; Morphine; Movement; Nalorphine; Naloxone; Naltrexone; Narcotic Antagonists | 1985 |
Direct inhibition of gonadotroph function by opiates.
Topics: Animals; Cells, Cultured; Female; Gonadotropin-Releasing Hormone; Luteinizing Hormone; Models, Biological; Morphine; Naltrexone; Pituitary Gland; Rats | 1985 |
Effects of morphine, naltrexone, and dextrorphan in untreated and morphine-treated pigeons.
Topics: Animals; Behavior, Animal; Body Weight; Columbidae; Conditioning, Operant; Dextrorphan; Dose-Response Relationship, Drug; Drug Tolerance; Morphinans; Morphine; Naloxone; Naltrexone; Stereoisomerism | 1985 |
Independent central and peripheral mediation of morphine-induced inhibition of gastrointestinal transit in rats.
Topics: Analgesia; Animals; Brain; Gastrointestinal Motility; Injections, Intraventricular; Injections, Subcutaneous; Male; Morphine; Naloxone; Naltrexone; Peripheral Nerves; Rats; Rats, Inbred Strains | 1986 |
Pharmacokinetics and pharmacodynamics of subcutaneous naltrexone pellets in the rat.
Topics: Animals; Drug Implants; Kinetics; Male; Metabolic Clearance Rate; Morphine; Naltrexone; Rats | 1986 |
Contralateral circling induced by tegmental morphine: anatomical localization, pharmacological specificity, and phenomenology.
Topics: Animals; Locomotion; Male; Morphine; Motor Activity; Muscimol; Naltrexone; Pimozide; Rats; Rotation; Substantia Nigra; Tegmentum Mesencephali | 1985 |
Pharmacokinetics of morphine and its surrogates V: Naltrexone and naltrexone conjugate pharmacokinetics in the dog as a function of dose.
Topics: Animals; Bile; Body Fluids; Chromatography, High Pressure Liquid; Dogs; Kidney; Kinetics; Liver; Morphine; Naloxone; Naltrexone | 1985 |
Morphine decreases 3H-norepinephrine release and increases endogenous norepinephrine levels in the isolated cat superior cervical ganglion.
Topics: Acetylcholine; Animals; Autonomic Fibers, Preganglionic; Cats; Electric Stimulation; Female; Ganglia, Sympathetic; In Vitro Techniques; Male; Morphine; Naltrexone; Norepinephrine | 1985 |
Hot-plate learning in mice is unaltered by immediate post-training administration of naloxone, naltrexone or morphine.
Topics: Animals; Endorphins; Hot Temperature; Learning; Male; Memory; Mice; Morphine; Naloxone; Naltrexone; Pain | 1985 |
Chronic stress, aging and morphine analgesia: chronic stress affects the reactivity to morphine in young mature but not old rats.
Topics: Age Factors; Aging; Analgesia; Analysis of Variance; Animals; Chronic Disease; Dose-Response Relationship, Drug; Male; Morphine; Naltrexone; Rats; Rats, Inbred Strains; Stress, Physiological; Time Factors | 1985 |
Opiate agonist-antagonist interactions: application of a three-key drug discrimination procedure.
Topics: Animals; Columbidae; Discrimination Learning; Dose-Response Relationship, Drug; Drug Interactions; Morphine; Naltrexone; Narcotic Antagonists; Narcotics | 1985 |
Prolactin analgesia: tolerance and cross-tolerance with morphine.
Topics: Analgesics; Animals; Bromocriptine; Drug Tolerance; Male; Mice; Morphine; Naltrexone; Prolactin | 1985 |
Cross-tolerance between morphine- and bombesin-induced inhibition of intestinal transit in rats.
Topics: Animals; Bombesin; Drug Tolerance; Gastrointestinal Motility; Male; Morphine; Naloxone; Naltrexone; Rats; Rats, Inbred Strains | 1985 |
Effects of buprenorphine on shock titration in squirrel monkeys.
Topics: Animals; Buprenorphine; Conditioning, Operant; Diprenorphine; Dose-Response Relationship, Drug; Drug Interactions; Electroshock; Male; Morphinans; Morphine; Naloxone; Naltrexone; Saimiri | 1985 |
beta-Funaltrexamine (beta-FNA) and neural tumor response in mice.
Topics: Animals; Male; Mice; Mice, Inbred A; Morphine; Naltrexone; Narcotic Antagonists; Neoplasm Transplantation; Neuroblastoma; Reaction Time | 1985 |
Effects of beta-funaltrexamine in normal and morphine-dependent rhesus monkeys: observational studies.
Topics: Animals; Azocines; Behavior, Animal; Dose-Response Relationship, Drug; Injections, Intraventricular; Injections, Subcutaneous; Macaca mulatta; Morphine; Muscle Relaxation; Naloxone; Naltrexone; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors | 1985 |
Antagonistic and rate-suppressing effects of opioid antagonists in the pigeon.
Topics: Animals; Azocines; Benzomorphans; Buprenorphine; Columbidae; Conditioning, Operant; Diprenorphine; Dose-Response Relationship, Drug; Morphine; Naloxone; Naltrexone; Narcotic Antagonists | 1985 |
Clinical evaluation of a naltrexone sustained-release preparation.
Topics: Delayed-Action Preparations; Drug Evaluation; Drug Implants; Humans; Injections, Intravenous; Kinetics; Male; Morphine; Naltrexone; Time Factors | 1985 |
Intraseptal morphine potentiates pentobarbital narcosis and hypothermia in the rat.
Topics: Anesthesia; Animals; Body Temperature; Cerebral Cortex; Drug Synergism; Injections; Male; Morphine; Naltrexone; Pentobarbital; Rats; Rats, Inbred Strains; Sleep; Time Factors | 1985 |
Quaternary naltrexone reverses morphine-induced behaviors.
Topics: Animals; Behavior, Animal; Locomotion; Male; Mice; Mice, Inbred C57BL; Morphine; Naltrexone; Quaternary Ammonium Compounds | 1985 |
Placenta ingestion enhances opiate analgesia in rats.
Topics: Analgesia; Animals; Diet; Electroshock; Female; Maternal Behavior; Morphine; Naltrexone; Pain; Placenta; Pregnancy; Rats; Sensory Thresholds | 1985 |
Acute effects of morphine on neurochemical estimates of activity of incertohypothalamic dopaminergic neurons in the male rat.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Dopamine; Electrochemistry; Hypothalamus; Male; Methyltyrosines; Morphine; Naltrexone; Neural Pathways; Neurons; Rats; Rats, Inbred Strains; Time Factors | 1985 |
Intracerebroventricular drug administration in pigeons.
Topics: Animals; Columbidae; Conditioning, Operant; Dose-Response Relationship, Drug; Injections, Intramuscular; Injections, Intraventricular; Morphine; Naloxone; Naltrexone; Pharmaceutical Preparations | 1985 |
Neonatal exposure to naltrexone affects morphine sensitivity and facilitates sexual behaviour in female rats.
Topics: Animals; Animals, Newborn; Copulation; Female; Morphine; Naltrexone; Posture; Rats; Rats, Inbred Strains; Sexual Behavior, Animal; Time Factors | 1985 |
Stereospecificity of 4,5-epoxymorphinan binding to the lambda site in rat brain.
Topics: Animals; Binding, Competitive; Brain; In Vitro Techniques; Male; Morphinans; Morphine; Naloxone; Naltrexone; Narcotics; Oxymorphone; Rats; Rats, Inbred Strains; Receptors, Opioid; Stereoisomerism | 1984 |
Duration of opiate receptor blockade determines tumorigenic response in mice with neuroblastoma: a role for endogenous opioid systems in cancer.
Topics: Analgesia; Animals; Cell Line; Male; Mice; Mice, Inbred Strains; Morphine; Naloxone; Naltrexone; Neuroblastoma; Receptors, Opioid | 1984 |
Design and synthesis of naltrexone-derived affinity labels with nonequilibrium opioid agonist and antagonist activities. Evidence for the existence of different mu receptor subtypes in different tissues.
Topics: Affinity Labels; Animals; Chemical Phenomena; Chemistry; Guinea Pigs; Ileum; Indicators and Reagents; Kinetics; Magnetic Resonance Spectroscopy; Male; Mice; Morphine; Muscle, Smooth; Naloxone; Naltrexone; Receptors, Opioid; Receptors, Opioid, mu; Structure-Activity Relationship; Vas Deferens | 1984 |
Enhancement of opiate-induced depressions in serum luteinizing hormone levels by the prior administration of naloxone in the male rat.
Topics: Animals; Binding, Competitive; Brain; Dose-Response Relationship, Drug; Gonadotropin-Releasing Hormone; Kinetics; Luteinizing Hormone; Male; Morphine; Naloxone; Naltrexone; Narcotics; Rats; Rats, Inbred Strains; Receptors, Opioid | 1984 |
Counteraction by naltrexone of stress-induced inhibition of TSH release: role of noradrenergic system.
Topics: Animals; Ditiocarb; Kinetics; Male; Morphine; Naloxone; Naltrexone; Norepinephrine; Pituitary Gland, Anterior; Rats; Rats, Inbred Strains; Stress, Physiological; Thyrotropin | 1984 |
Role of spinal mu opioid receptors in the development of morphine tolerance and dependence.
Topics: Analgesia; Animals; Body Weight; Drug Tolerance; Humans; Male; Morphine; Morphine Dependence; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Spinal Cord | 1984 |
Hyperthermic response of the cat to intraventricular injection of the opioid delta-receptor agonist D-Ala2-D-Leu5-enkephalin.
Topics: Animals; Body Temperature; Body Temperature Regulation; Cats; Drug Tolerance; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Injections, Intraventricular; Morphine; Naloxone; Naltrexone; Receptors, Opioid; Receptors, Opioid, delta | 1984 |
Comparative antagonism by naltrexone and naloxone of mu, kappa, and delta agonists.
Topics: Animals; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vas Deferens | 1984 |
Effects of naltrexone and prolyl-leucyl-glycinamide on drug-induced tremor and rigidity in the rat.
Topics: Animals; Female; Injections, Intraventricular; Morphine; MSH Release-Inhibiting Hormone; Muscle Rigidity; Muscle Tonus; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Time Factors; Tremor; Tremorine | 1981 |
Pharmacological characterization in vivo of the novel opiate, beta-funaltrexamine.
Topics: Acetates; Acetic Acid; Analgesics, Opioid; Animals; Drug Interactions; Female; Male; Mice; Morphine; Nalorphine; Naloxone; Naltrexone; Narcotics; Pain; Reaction Time | 1982 |
Evidence for a role of the ventro-medial posterior hypothalamus in nociceptive processes in the rat.
Topics: Animals; beta-Endorphin; Dynorphins; Electroshock; Endorphins; Enkephalin, Methionine; Hypothalamus; Hypothalamus, Posterior; Male; Morphine; Naltrexone; Nociceptors; Pain; Protein Precursors; Rats; Rats, Inbred Strains; Stereotaxic Techniques | 1983 |
Opioid peptides and seizures in the spontaneously epileptic Mongolian gerbil.
Topics: Animals; beta-Endorphin; Cerebral Cortex; Dynorphins; Endorphins; Enkephalin, Methionine; Epilepsy; Gerbillinae; Morphine; Naltrexone; Narcotics; Seizures | 1983 |
Is the hypothermic effect of alpha-methyldopa mediated by opioid peptides?
Topics: Animals; Body Temperature; Endorphins; Male; Methyldopa; Morphine; Naltrexone; Rats; Rats, Inbred Strains | 1984 |
Morphine analgesia after intrathecal administration of a narcotic agonist, chloroxymorphamine and antagonist, chlornaltrexamine.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Interactions; Hydromorphone; Injections, Spinal; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Nitrogen Mustard Compounds; Oxymorphone; Rats | 1980 |
Pharmacological studies with an alkylating narcotic agonist, chloroxymorphamine, and antagonist, chlornaltrexamine.
Topics: Analgesics; Animals; Brain; Hydromorphone; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Nitrogen Mustard Compounds; Oxymorphone | 1980 |
Effects of beta-endorphin and its fragments on inhibitory avoidance behavior in rats.
Topics: alpha-Endorphin; Animals; Avoidance Learning; beta-Endorphin; beta-Lipotropin; Dose-Response Relationship, Drug; Endorphins; gamma-Endorphin; Injections, Intraventricular; Injections, Subcutaneous; Male; Mental Recall; Morphine; Naltrexone; Nociceptors; Peptide Fragments; Rats; Rats, Inbred Strains; Reaction Time; Retention, Psychology | 1983 |
Discriminative stimulus effects of reversible and irreversible opiate agonists: morphine, oxymorphazone and buprenorphine.
Topics: Animals; Buprenorphine; Columbidae; Discrimination Learning; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Hydromorphone; Morphinans; Morphine; Naltrexone; Oxymorphone; Time Factors | 1984 |
Irreversible and reversible narcotic agonists: discriminative and analgesic effects of buprenorphine, oxymorphazone, and morphine.
Topics: Animals; Buprenorphine; Columbidae; Discrimination Learning; Dose-Response Relationship, Drug; Hydromorphone; Mice; Morphinans; Morphine; Naltrexone; Nociceptors; Oxymorphone | 1984 |
Selective protection of stereospecific enkephalin and opiate binding against inactivation by N-ethylmaleimide: evidence for two classes of opiate receptors.
Topics: Animals; Binding, Competitive; Brain; Endorphins; Enkephalins; Ethylmaleimide; Kinetics; Ligands; Male; Morphine; Naloxone; Naltrexone; Rats; Receptors, Opioid | 1980 |
Effects of pentazocine and other opiates on shock detection in the rat: involvement of opiate and dopamine receptors.
Topics: Animals; Electroshock; Male; Morphine; Naltrexone; Narcotics; Pentazocine; Prejudice; Rats; Receptors, Dopamine; Receptors, Opioid; Reinforcement Schedule | 1980 |
Opiate receptors: problems of definition and characterization.
Topics: Animals; Binding Sites; Brain; Caudate Nucleus; Cyclazocine; Endorphins; Enkephalins; Hippocampus; Humans; Morphine; Naloxone; Naltrexone; Receptors, Opioid | 1980 |
The effects of opiate agonists on growth hormone and prolactin release in rats.
Topics: Animals; Apomorphine; Enkephalins; Growth Hormone; Male; Methadone; Morphine; Naloxone; Naltrexone; Parasympathomimetics; Prolactin; Rats; Receptors, Cholinergic; Receptors, Dopamine; Receptors, Opioid; Secretory Rate | 1980 |
Location and characterization of opiate receptors regulating pituitary secretion.
Topics: Animals; Apomorphine; Chromatography, Gel; Corpus Striatum; Endorphins; Enkephalins; Female; Growth Hormone; Hypothalamus; Luteinizing Hormone; Morphine; Naltrexone; Pituitary Gland, Anterior; Prolactin; Rats; Receptors, Opioid; Thyrotropin | 1980 |
Possible role of an endogenous opiate in the cardiovascular effects of central alpha adrenoceptor stimulation in spontaneously hypertensive rats.
Topics: Anesthesia; Animals; Blood Pressure; Clonidine; Dose-Response Relationship, Drug; Drug Interactions; Endorphins; Heart Rate; Hypertension; Male; Methyldopa; Morphine; Naloxone; Naltrexone; Rats; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Receptors, Opioid; Time Factors; Yohimbine | 1980 |
Depressant and excitant effects of intraspinal microinjections of morphine and methionine-enkephalin in the cat.
Topics: Animals; Cats; Endorphins; Enkephalins; Evoked Potentials; Female; Ganglia, Spinal; Male; Morphine; Motor Neurons; Naltrexone; Nerve Fibers; Nociceptors; Reflex; Spinal Cord; Synapses; Synaptic Transmission | 1980 |
Influence of morphine and naltrexone on the intraocular pressure of conscious cynomolgus monkeys (Macaca fascicularis).
Topics: Animals; Drug Combinations; Intraocular Pressure; Macaca; Macaca fascicularis; Morphine; Naloxone; Naltrexone; Receptors, Opioid | 1980 |
Discriminative stimulus effects of prototype opiate receptor agonists in monkeys.
Topics: Animals; Apomorphine; Cyclazocine; Ethylketocyclazocine; Female; Generalization, Stimulus; Haloperidol; Male; Models, Biological; Morphine; Naltrexone; Phenazocine; Prejudice; Receptors, Opioid; Saimiri | 1980 |
Quaternary naltrexone: evidence for the central mediation of discriminative stimulus effects of narcotic agonists and antagonists.
Topics: Animals; Brain; Columbidae; Discrimination, Psychological; Etorphine; Macaca mulatta; Male; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Receptors, Opioid | 1981 |
Different opioid systems may participate in post-electro-convulsive shock (ECS) analgesia and catalepsy.
Topics: Animals; Drug Tolerance; Electroshock; Male; Morphine; Motor Activity; Naloxone; Naltrexone; Nociceptors; Rats; Receptors, Opioid | 1981 |
Antagonism by chlornaltrexamine of some effects of delta 9-tetrahydrocannabinol in rats.
Topics: Analgesia; Animals; Dronabinol; Drug Tolerance; Humans; Hypothermia; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Nitrogen Mustard Compounds; Rats; Receptors, Opioid; Substance-Related Disorders | 1981 |
Seasonal variation in the apparent number of binding sites for 3H-opioid agonists and antagonists.
Topics: Animals; Binding Sites; Brain; Dihydromorphine; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Kinetics; Male; Mice; Morphinans; Morphine; Naloxone; Naltrexone; Receptors, Opioid; Seasons | 1981 |
In vivo receptor binding of the opiate partial agonist, buprenorphine, correlated with its agonistic and antagonistic actions.
Topics: Analgesia; Animals; Brain; Buprenorphine; Dose-Response Relationship, Drug; Male; Morphinans; Morphine; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid | 1981 |
Naltrexone improves survival rate and cardiovascular function in canine hemorrhagic shock.
Topics: Animals; Dogs; Dose-Response Relationship, Drug; Drug Tolerance; Female; Hemodynamics; Male; Morphine; Naloxone; Naltrexone; Receptors, Opioid; Shock, Hemorrhagic | 1982 |
Antagonism of morphine-induced behavioral suppression by opiate receptor alkylators.
Topics: Amphetamine; Animals; Brain; Conditioning, Operant; Exploratory Behavior; Male; Morphine; Muridae; Naloxone; Naltrexone; Nitrogen Mustard Compounds; Nociceptors; Receptors, Opioid | 1982 |
Stimulus properties of opioids with mixed agonist and antagonist activity.
Topics: Animals; Conditioning, Psychological; Cyclazocine; Dogs; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Phencyclidine; Rats; Receptors, Opioid; Saimiri | 1982 |
Interactions between narcotic agonists, partial agonists andd antagonists evaluated by punished an unpunished behavior in the rat.
Topics: Animals; Conditioning, Psychological; Cyclazocine; Dose-Response Relationship, Drug; Ethylketocyclazocine; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Phenazocine; Punishment; Rats; Rats, Inbred Strains; Receptors, Opioid | 1982 |
Opiate, enkephalin, and endorphin analgesia: relations to a single subpopulation of opiate receptors.
Topics: Analgesia; Animals; Humans; Lethal Dose 50; Morphine; Muridae; Naloxone; Naltrexone; Oxymorphone; Receptors, Opioid; Respiration; Respiratory Insufficiency | 1981 |
Release of prolactin in response to microinjection of morphine into mesencephalic dorsal raphe nucleus.
Topics: Animals; Brain Stem; Female; Mesencephalon; Morphine; Naltrexone; Prolactin; Raphe Nuclei; Rats; Rats, Inbred Strains; Receptors, Opioid | 1982 |
Intraseptally injected opiate agents: effects on morphine-induced behaviour of cats.
Topics: Animals; Behavior, Animal; beta-Endorphin; Cats; Endorphins; Enkephalin, Methionine; Fentanyl; Morphine; Naloxone; Naltrexone; Narcotics; Receptors, Opioid; Septal Nuclei; Septum Pellucidum | 1982 |
Extent and control of shock affects naltrexone sensitivity of stress-induced analgesia and reactivity to morphine.
Topics: Animals; Dose-Response Relationship, Drug; Electroshock; Helplessness, Learned; Humans; Male; Morphine; Naloxone; Naltrexone; Nociceptors; Rats; Receptors, Opioid; Sensory Thresholds; Stress, Physiological | 1982 |
Opiate and non-opiate aspects of morphine induced seizures.
Topics: Amygdala; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Evoked Potentials; Injections, Intraperitoneal; Kindling, Neurologic; Male; Morphine; Motor Activity; Muridae; Naltrexone; Nociceptors; Receptors, Opioid; Seizures | 1982 |
Improved assays for the assessment of kappa- and delta-properties of opioid ligands.
Topics: Animals; Cyclazocine; Ethylketocyclazocine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Vas Deferens | 1982 |
Relative involvement of receptor subtypes in opioid-induced inhibition of gastrointestinal transit in mice.
Topics: Animals; Charcoal; Cyclazocine; Drug Interactions; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Female; Gastrointestinal Motility; Male; Mice; Morphine; Nalorphine; Naltrexone; Receptors, Opioid | 1983 |
Effects of opiate antagonists and putative mu- and kappa-agonists on milk intake in rat and squirrel monkey.
Topics: Animals; Buprenorphine; Cyclazocine; Diazepam; Diprenorphine; Drinking; Ethylketocyclazocine; Etorphine; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Saimiri; Taste | 1982 |
Analgesia induced by electroconvulsive shock: brain enkephalins may mediate tolerance but not the induction of analgesia.
Topics: Animals; Brain; Drug Tolerance; Electroshock; Enkephalins; Male; Morphine; Muridae; Naltrexone; Nociceptors; Receptors, Opioid; Sensory Thresholds; Synaptic Transmission | 1983 |
Regulation of opiate receptors in mouse brain: arcuate nuclear lesion induces receptor up-regulation and supersensitivity to opiates.
Topics: Animals; Arcuate Nucleus of Hypothalamus; Brain; Cell Membrane; Dihydromorphine; Kinetics; Mesencephalon; Mice; Mice, Inbred ICR; Morphine; Morphine Derivatives; Naltrexone; Receptors, Opioid; Sodium Glutamate | 1983 |
An opiate binding site in the rat brain is highly selective for 4,5-epoxymorphinans.
Topics: Animals; Brain Chemistry; Dihydromorphine; Diprenorphine; Morphine; Nalorphine; Naloxone; Naltrexone; Rats; Receptors, Opioid; Sodium; Tissue Distribution | 1983 |
Naltrexone fails to antagonize the sigma effects of PCP and SKF 10,047 in the dog.
Topics: Animals; Body Temperature; Dogs; Female; Heart Rate; Morphine; Naloxone; Naltrexone; Paraplegia; Phenazocine; Phencyclidine; Receptors, Opioid; Receptors, sigma; Reflex | 1983 |
Morphine exacerbates anaphylactic shock in mice by stimulating central opiate receptors.
Topics: Anaphylaxis; Animals; Azocines; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Naltrexone; Receptors, Opioid | 1983 |
Multi-dimensional analyses of behavior in mice treated with morphine, endorphins and [des-tyrosine1]-gamma-endorphin.
Topics: Animals; Behavior, Animal; beta-Endorphin; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Injections, Intraventricular; Male; Mice; Morphine; Naltrexone; Peptide Fragments | 1983 |
Chronic naltrexone increases opiate binding in brain and produces supersensitivity to morphine in the locus coeruleus of the rat.
Topics: Animals; Brain; Etorphine; Locus Coeruleus; Male; Morphine; Naloxone; Naltrexone; Narcotics; Neurons; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Synaptic Transmission; Yohimbine | 1983 |
Evidence from opiate binding studies that heroin acts through its metabolites.
Topics: Animals; Brain; Cell Membrane; Heroin; Male; Morphine; Morphine Derivatives; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Structure-Activity Relationship | 1983 |
Body temperature effects of opioids administered into the periaqueductal grey area of rat brain.
Topics: Animals; Body Temperature Regulation; Endorphins; Male; Morphine; Naltrexone; Periaqueductal Gray; Rats; Receptors, Opioid; Time Factors | 1983 |
Nonspecific convulsions are induced by morphine but not D-Ala2-methionine-enkephalinamide at cortical sites.
Topics: Animals; Cerebral Cortex; Drug Tolerance; Electroencephalography; Enkephalin, Methionine; Evoked Potentials; Injections, Intraventricular; Male; Methadone; Morphine; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Seizures | 1984 |
Endogenous opioids mediate ECS-induced catalepsy at supraspinal levels.
Topics: Animals; Brain; Catalepsy; Electroshock; Endorphins; Humans; Male; Morphine; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Seizures; Spinal Cord | 1984 |
Differential role of the opioid mu and delta receptors in the activation of prolactin (PRL) and growth hormone (GH) secretion by morphine in the male rat.
Topics: Animals; Drug Interactions; Enkephalin, Leucine; Growth Hormone; Injections, Intraventricular; Male; Morphine; Naloxone; Naltrexone; Prolactin; Rats; Rats, Inbred Strains; Receptors, Opioid | 1984 |
Opioid antagonism of electroshock-induced seizures.
Topics: Animals; beta-Endorphin; Electroshock; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Mice; Mice, Inbred C57BL; Morphine; Naltrexone; Narcotics; Seizures; Time Factors | 1984 |
Endogenous opiate involvement in acute and chronic stress-induced changes in plasma LH concentrations in the male rat.
Topics: Animals; Endorphins; Gonadotropin-Releasing Hormone; Luteinizing Hormone; Male; Morphine; Naltrexone; Rats; Rats, Inbred Strains; Starvation; Stress, Physiological | 1984 |
Narcotic discrimination in pigeons: antagonism by naltrexone.
Topics: Animals; Columbidae; Cyclazocine; Discrimination, Psychological; Dose-Response Relationship, Drug; Ethylketocyclazocine; Meperidine; Morphine; Naloxone; Naltrexone; Narcotics | 1984 |
Predictors of favorable outcome following naltrexone treatment.
Topics: Employment; Humans; Morphine; Naloxone; Naltrexone; Opioid-Related Disorders; Time Factors | 1983 |
Effects of b-FNA in drug-naive and morphine-dependent rhesus monkeys.
Topics: Animals; Macaca mulatta; Morphine; Naltrexone; Substance-Related Disorders; Time Factors | 1984 |
Footshock induced hyperthermia.
Topics: Animals; Drug Tolerance; Electroshock; Endorphins; Fever; Male; Morphine; Naltrexone; Rats; Rats, Inbred Strains; Stress, Physiological | 1984 |
Locomotor activity and opiate effects in male and female hamsters.
Topics: Analysis of Variance; Animals; Cricetinae; Female; Male; Mesocricetus; Morphine; Motor Activity; Naltrexone; Narcotics; Sex Factors | 1984 |
Stress induced alteration of opiate withdrawal.
Topics: Animals; Body Weight; Humans; Male; Morphine; Naltrexone; Rats; Rats, Inbred Strains; Stress, Physiological; Substance Withdrawal Syndrome | 1984 |
Endogenous opiates and stress. Behavioral activation elicited in the rat and effects of naltrexone, diprenorphine and morphine.
Topics: Animals; Behavior, Animal; Diprenorphine; Endorphins; Humans; Male; Morphinans; Morphine; Naloxone; Naltrexone; Noise; Rats; Rats, Inbred Strains; Receptors, Drug; Stress, Psychological; Time Factors | 1984 |
The effects of intrathecal morphine and naltrexone on autotomy in sciatic nerve sectioned rats.
Topics: Animals; Behavior, Animal; Differential Threshold; Disease Models, Animal; Injections, Spinal; Male; Morphine; Naloxone; Naltrexone; Nociceptors; Pain; Rats; Rats, Inbred Strains; Sciatic Nerve; Time Factors | 1984 |
Endorphins in endotoxin-induced hyperglycemia in mice.
Topics: Animals; Endorphins; Endotoxins; Hyperglycemia; Male; Mice; Mice, Inbred C3H; Morphine; Naloxone; Naltrexone; Quaternary Ammonium Compounds | 1983 |
An antiabsorptive basis for precipitated withdrawal diarrhea in morphine-dependent rats.
Topics: Animals; Atropine; Biological Transport; Diarrhea; Gastrointestinal Motility; Hexamethonium Compounds; Humans; Intestinal Absorption; Male; Morphine; Morphine Dependence; Naltrexone; Quaternary Ammonium Compounds; Rats; Rats, Inbred Lew; Substance Withdrawal Syndrome; Water-Electrolyte Balance | 1984 |
Increased brain size and cellular content in infant rats treated with an opiate antagonist.
Topics: Animals; Animals, Newborn; Body Weight; Brain; Cerebellum; Morphine; Naloxone; Naltrexone; Neuroglia; Organ Size; Rats; Rats, Inbred Strains; Somatosensory Cortex | 1983 |
Role of endorphins in endotoxin-induced hyperglycaemia in mice.
Topics: Animals; Blood Glucose; Drug Tolerance; Endorphins; Endotoxins; Hyperglycemia; Male; Mice; Mice, Inbred C3H; Morphine; Naloxone; Naltrexone | 1983 |
Opiate antagonists, morphine and spatial memory in rats.
Topics: Animals; Dose-Response Relationship, Drug; Endorphins; Male; Memory; Morphine; Naloxone; Naltrexone; Rats; Retention, Psychology | 1983 |
Morphine antagonizes pentobarbital-induced anesthesia.
Topics: Anesthesia; Animals; Atropine; Behavior, Animal; Electroencephalography; Male; Morphine; Naloxone; Naltrexone; Pentobarbital; Rabbits; Seizures | 1983 |
Inhibition of morphine-induced analgesia and locomotor activity in strains of mice: a comparison of long-acting opiate antagonists.
Topics: Animals; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Morphine; Motor Activity; Naloxone; Naltrexone; Pain; Species Specificity | 1983 |
Proanaphylactic action of morphine is mediated through a central cholinergic mechanism.
Topics: Anaphylaxis; Animals; Atropine Derivatives; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Parasympathetic Nervous System | 1983 |
Prolonged excretion of morphine in rats during protracted abstinence: lack of effect of naltrexone.
Topics: Animals; Body Weight; Gas Chromatography-Mass Spectrometry; Humans; Male; Morphine; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome | 1983 |
A preliminary description of acute physical dependence on morphine in the vervet monkey.
Topics: Animals; Behavior, Animal; Catheterization; Chlorocebus aethiops; Humans; Male; Morphine; Morphine Dependence; Naloxone; Naltrexone; Substance Withdrawal Syndrome | 1983 |
Reversal of morphine-induced catalepsy in the rat by narcotic antagonists and their quaternary derivatives.
Topics: Animals; Catalepsy; Humans; Injections, Intraventricular; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains | 1983 |
Spinal antagonism of tolerance and dependence induced by systemically administered morphine.
Topics: Animals; Drug Tolerance; Humans; Male; Morphine; Morphine Dependence; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Reaction Time; Spinal Cord | 1983 |
Opioid peptides mediate the suppressive effect of stress on natural killer cell cytotoxicity.
Topics: Animals; Cytotoxicity, Immunologic; Dose-Response Relationship, Drug; Endorphins; Female; Killer Cells, Natural; Morphine; Naltrexone; Rats; Rats, Inbred F344; Stress, Physiological | 1984 |
Naloxone improves, and morphine exacerbates, experimental shock induced by release of endogenous histamine by compound 48/80.
Topics: Animals; Central Nervous System; Endorphins; Histamine; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Naltrexone; p-Methoxy-N-methylphenethylamine; Shock | 1984 |
Electrochemical chromatographic determinations of morphine antagonists in biological fluids, with applications.
Topics: Animals; Chromatography, High Pressure Liquid; Dogs; Electrochemistry; Erythrocytes; Humans; In Vitro Techniques; Morphine; Naloxone; Naltrexone; Protein Binding; Ultracentrifugation | 1984 |
Phencyclidine-like discriminative stimulus properties of psychotomimetic opioids.
Topics: Animals; Columbidae; Cyclazocine; Discrimination, Psychological; Ethylketocyclazocine; Generalization, Psychological; Generalization, Stimulus; Morphine; Naltrexone; Phencyclidine; Rats; Saimiri | 1982 |
Stimulus effects of morphine in the monkey: quantitative analysis of antagonism.
Topics: Animals; Discrimination Learning; Dose-Response Relationship, Drug; Drug Interactions; Female; Haplorhini; Male; Morphine; Naltrexone; Prejudice; Saimiri | 1980 |
Development of drug delivery systems for use in treatment of narcotic addiction.
Topics: Animals; Delayed-Action Preparations; Drug Compounding; Drug Implants; Haplorhini; Humans; Morphine; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; United States | 1981 |
An improved long-acting delivery system for narcotic antagonists.
Topics: Animals; Drug Implants; Haplorhini; Morphine; Naltrexone; Narcotic Antagonists | 1981 |
Historical perspective on the chemistry and development of naltrexone.
Topics: Animals; Benzomorphans; Heroin Dependence; History, 20th Century; Humans; Morphine; Naloxone; Naltrexone; Narcotic Antagonists | 1981 |
Pharmacological evaluation of narcotic antagonist delivery systems in rhesus monkeys.
Topics: Animals; Drug Evaluation, Preclinical; Drug Implants; Infusions, Parenteral; Macaca mulatta; Morphine; Naltrexone; Narcotic Antagonists; Self Administration; Time Factors | 1981 |
Threshold differences for naloxone and naltrexone in the hypothalamus and midbrain using fixed ratio brain self-stimulation in rats.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Electrodes, Implanted; Hypothalamus; Male; Mesencephalon; Morphine; Naloxone; Naltrexone; Rats; Reinforcement Schedule; Self Stimulation | 1981 |
Effects of selected opioid agonists and antagonists on DMT- and LSD-25-induced disruption of food-rewarded bar pressing behavior in the rat.
Topics: Animals; Conditioning, Operant; Drug Interactions; Drug Synergism; Lysergic Acid Diethylamide; Male; Methadone; Morphine; N,N-Dimethyltryptamine; Naloxone; Naltrexone; Narcotics; Rats; Reinforcement, Psychology; Tryptamines | 1981 |
Cardiovascular effects of naloxone, naltrexone and morphine in the squirrel monkey.
Topics: Animals; Blood Pressure; Dose-Response Relationship, Drug; Heart Rate; Male; Morphine; Naloxone; Naltrexone; Saimiri | 1983 |
Attenuation of alcohol drinking in tetrahydroisoquinoline-treated rats by morphine and naltrexone.
Topics: Alcohol Drinking; Animals; Body Weight; Drinking Behavior; Feeding Behavior; Isoquinolines; Male; Morphine; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Tetrahydroisoquinolines | 1983 |
Effects of opiate agonists and antagonists on fluid intake and saccharin choice in the rat.
Topics: Animals; Choice Behavior; Drinking Behavior; Enkephalins; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Saccharin | 1983 |
Involvement of central muscarinic cholinergic mechanisms in opioid stress analgesia.
Topics: Animals; Electroshock; Endorphins; Male; Morphine; Naltrexone; Oxotremorine; Pain; Rats; Rats, Inbred Strains; Receptors, Cholinergic; Receptors, Muscarinic; Scopolamine; Stress, Physiological | 1983 |
Acquisition of brightness discrimination in the rat is impaired by opiates with psychotomimetic properties.
Topics: Animals; Avoidance Learning; Cyclazocine; Discrimination Learning; Male; Morphine; Nalorphine; Naltrexone; Narcotics; Pentazocine; Phenazocine; Photic Stimulation; Psychotropic Drugs; Rats; Rats, Inbred F344 | 1983 |
Narcotic discrimination in pigeons.
Topics: Animals; Clonidine; Codeine; Columbidae; Cyclazocine; Discrimination Learning; Dose-Response Relationship, Drug; Ethylketocyclazocine; Ketamine; Meperidine; Morphine; Nalorphine; Naltrexone; Narcotics; Pentazocine; Pentobarbital; Species Specificity | 1980 |
Classification of narcotics on the basis of their reinforcing, discriminative, and antagonist effects in rhesus monkeys.
Topics: Animals; Behavior, Animal; Conditioning, Operant; Cyclazocine; Discrimination, Psychological; Ethylketocyclazocine; Humans; Macaca; Macaca mulatta; Morphine; Naloxone; Naltrexone; Narcotics; Opioid-Related Disorders; Reinforcement, Psychology; Self Administration | 1982 |
Opiate antagonists stimulate ruminal motility of conscious goats.
Topics: Animals; Female; Goats; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists; Rumen | 1982 |
Opiates and thermoregulation in mice. II. Effects of opiate antagonists.
Topics: Animals; Body Temperature Regulation; Dose-Response Relationship, Drug; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Time Factors | 1982 |
Opiate modification of amygdaloid-kindled seizures in rats.
Topics: Amygdala; Animals; Electroencephalography; Kindling, Neurologic; Male; Morphine; Naloxone; Naltrexone; Narcotics; Rats; Rats, Inbred Strains | 1982 |
Adrenal medullary enkephalin-like peptides may mediate opioid stress analgesia.
Topics: Adrenal Medulla; Analgesia; Animals; Electroshock; Endorphins; Enkephalins; Male; Morphine; Naltrexone; Rats; Reserpine; Sodium Chloride; Stress, Physiological; Time Factors | 1982 |
Quaternary narcotic antagonists' relative ability to prevent antinociception and gastrointestinal transit inhibition in morphine-treated rats as an index of peripheral selectivity.
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Gastrointestinal Motility; Male; Morphine; Nalorphine; Naloxone; Naltrexone; Pain; Rats; Structure-Activity Relationship | 1982 |
Effects of yohimbine and naltrexone in counteraction of the morphine Straub tail and the amphetamine-potentiated morphine Straub tail in mice.
Topics: Amphetamine; Animals; Male; Mice; Morphine; Naloxone; Naltrexone; Phentolamine; Tail; Yohimbine | 1982 |
Development of tolerance to the effects of morphine on luteinizing hormone secretion as a function of castration in the male rat.
Topics: Analgesics; Animals; Brain; Castration; Dose-Response Relationship, Drug; Drug Tolerance; Luteinizing Hormone; Male; Morphine; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Testosterone | 1982 |
Effects of opiate antagonists and of morphine on chlordiazepoxide-induced hyperdipsia in the water-deprived rat.
Topics: Analysis of Variance; Animals; Chlordiazepoxide; Drinking; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Thirst; Water Deprivation | 1982 |
Palatability-induced drinking after administration of morphine, naltrexone and diazepam in the non-deprived rat.
Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Drinking; Male; Morphine; Muridae; Naloxone; Naltrexone; Taste | 1982 |
Naltrexone effects on morphine and food self-administration in morphine-dependent rhesus monkeys.
Topics: Animals; Conditioning, Operant; Food; Humans; Macaca mulatta; Male; Morphine; Morphine Dependence; Naloxone; Naltrexone; Self Administration; Substance Withdrawal Syndrome | 1981 |
Antagonism of gut, but not central effects of morphine with quaternary narcotic antagonists.
Topics: Animals; Central Nervous System; Diarrhea; Digestive System; Dogs; Female; Humans; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Rats; Rats, Inbred Strains; Species Specificity; Substance Withdrawal Syndrome | 1982 |
Acute and chronic effects of naltrexone and naloxone on schedule-controlled behavior of squirrel monkeys and pigeons.
Topics: Animals; Behavior, Animal; Columbidae; Conditioning, Psychological; Dose-Response Relationship, Drug; Food; Male; Morphine; Naloxone; Naltrexone; Saimiri; Time Factors | 1981 |
Disposition of morphine in rat brain: relationship to biological activity.
Topics: Animals; Brain; Chromatography, Gas; Male; Morphine; Naltrexone; Pain; Radioimmunoassay; Rats | 1981 |
Three-choice drug discrimination in the rat: morphine, cyclazocine and saline.
Topics: Animals; Cyclazocine; Dextroamphetamine; Discrimination Learning; Discrimination, Psychological; Generalization, Stimulus; Male; Morphine; Naltrexone; Pentazocine; Rats; Secobarbital; Sodium Chloride | 1981 |
Suppression of drinking by naloxone in rats homo- and heterozygous for diabetes insipidus.
Topics: Animals; Diabetes Insipidus; Drinking Behavior; Heterozygote; Homozygote; Male; Morphine; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Time Factors | 1981 |
Naltrexone and the tail flick reflex.
Topics: Analgesics; Animals; Drug Interactions; Drug Tolerance; Male; Morphine; Naloxone; Naltrexone; Nociceptors; Rats; Rats, Inbred Strains; Reflex | 1981 |
Effect of morphine on rectal temperature after acute and chronic treatment in the rat.
Topics: Adrenalectomy; Animals; Body Temperature; Drug Tolerance; Male; Morphine; Naltrexone; Rats; Time Factors | 1981 |
Discriminative stimulus effects of cyclazocine in the rat.
Topics: Animals; Cyclazocine; Dose-Response Relationship, Drug; Generalization, Stimulus; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Prejudice; Psychotropic Drugs; Rats; Stimulation, Chemical; Time Factors | 1980 |
Self-administration of D-Ala2-Met-enkephalinamide at hypothalamic self-stimulation sites.
Topics: Animals; Dextrorphan; Dose-Response Relationship, Drug; Electric Stimulation; Endorphins; Enkephalins; Hypothalamus; Levallorphan; Levorphanol; Male; Morphine; Naloxone; Naltrexone; Rats; Self Stimulation | 1980 |
Alterations of evoked potentials link research in attention dysfunction to peptide response symptoms of schizophrenia.
Topics: Acoustic Stimulation; Attention; Endorphins; Evoked Potentials; Humans; Morphine; Naltrexone; Pain; Peptides; Schizophrenia; Schizophrenic Psychology | 1980 |
Pro- and anticonvulsant action of morphine in rats.
Topics: Animals; Anticonvulsants; Convulsants; Male; Morphine; Motor Activity; Naltrexone; Rats; Time Factors | 1980 |
Antinociceptive comparison of quipazine and morphine.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Quinolines; Quipazine; Reaction Time | 1980 |
Stereoselectivity of the stimulus effects of morphine and cyclazocine in the squirrel monkey.
Topics: Animals; Avoidance Learning; Behavior, Animal; Cyclazocine; Dose-Response Relationship, Drug; Generalization, Psychological; Morphine; Naltrexone; Prejudice; Saimiri; Stereoisomerism | 1980 |
Orally administered opioid antagonists reverse both mu and kappa opioid agonist delay of gastrointestinal transit in the guinea pig.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Gastrointestinal Transit; Guinea Pigs; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1995 |
Involvement of the dorsal raphe but not median raphe nucleus in morphine-induced increases in serotonin release in the rat forebrain.
Topics: Animals; Behavior, Animal; Body Temperature; Circadian Rhythm; Extracellular Space; Histocytochemistry; Male; Microdialysis; Morphine; Naltrexone; Narcotic Antagonists; Prosencephalon; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Receptor Agonists | 1995 |
Differential modulation of alpha 2-adrenergic and mu-opioid spinal antinociception by neuropeptide FF.
Topics: Adrenergic alpha-Agonists; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Synergism; Imidazoles; Male; Medetomidine; Morphine; Naltrexone; Narcotic Antagonists; Neuropeptides; Oligopeptides; Pain; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Opioid, mu; Spinal Cord; Time Factors | 1995 |
Ultra-low concentrations of naloxone selectively antagonize excitatory effects of morphine on sensory neurons, thereby increasing its antinociceptive potency and attenuating tolerance/dependence during chronic cotreatment.
Topics: Analgesia; Analgesics, Opioid; Animals; Behavior, Animal; Culture Techniques; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Electrophysiology; Ganglia, Spinal; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Neurons, Afferent; Pain Measurement; Substance Withdrawal Syndrome; Substance-Related Disorders | 1995 |
Cocaine self-administration and naltrindole, a delta-selective opioid antagonist.
Topics: Animals; Cocaine; Conditioning, Operant; Drug Implants; Female; Male; Morphine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; Receptors, Opioid, delta; Self Administration | 1995 |
Effects of naltrexone on morphine-induced tolerance and physical dependence and changes in cellular immune function in mice.
Topics: Animals; B-Lymphocytes; Body Weight; Cell Division; Drug Implants; Drug Tolerance; Female; Immunity, Cellular; Killer Cells, Natural; Mice; Morphine; Morphine Dependence; Naltrexone; Substance Withdrawal Syndrome; T-Lymphocytes | 1995 |
The formalin-induced expression of tachykinin peptide and neurokinin receptor messenger RNAs in rat sensory ganglia and spinal cord is modulated by opiate preadministration.
Topics: Animals; Formaldehyde; Ganglia, Spinal; Gene Expression Regulation; Male; Morphine; Naltrexone; Neurokinin B; Pain; Premedication; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-3; RNA, Messenger; Spinal Cord; Substance P; Time Factors | 1995 |
Kappa opioid inhibition of morphine and cocaine self-administration in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Cocaine; Dose-Response Relationship, Drug; Extinction, Psychological; Female; Morphine; Naltrexone; Narcotics; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reinforcement, Psychology; Self Administration | 1995 |
Attenuation of tolerance to, and physical dependence on, morphine in the rat by inhibition of nitric oxide synthase.
Topics: Animals; Arginine; Drug Implants; Drug Tolerance; Enzyme Inhibitors; Male; Morphine; Morphine Dependence; Naltrexone; Nitric Oxide Synthase; omega-N-Methylarginine; Pain Measurement; Rats; Rats, Sprague-Dawley | 1995 |
CCB, a novel specific kappa opioid agonist, which discriminates between opioid and sigma 1 recognition sites.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzomorphans; Binding, Competitive; Male; Mice; Morphine; Naltrexone; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa | 1995 |
Morphine and naltrexone modulate D2 but not D1 receptor induced motor behavior in MPTP-lesioned monkeys.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Behavior, Animal; Functional Laterality; Macaca mulatta; Male; Morphine; Naltrexone; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, sigma | 1995 |
CNS levels of mu opioid receptor (MOR-1) mRNA during chronic treatment with morphine or naltrexone.
Topics: Animals; Central Nervous System; Drug Administration Schedule; Drug Tolerance; Male; Morphine; Naltrexone; Nucleic Acid Hybridization; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; RNA, Messenger; Sensitivity and Specificity; Time Factors; Up-Regulation | 1995 |
Effects of a highly selective nonpeptide delta opioid receptor agonist, TAN-67, on morphine-induced antinociception in mice.
Topics: Analgesics; Animals; Drug Interactions; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Subcutaneous; Male; Mice; Mice, Inbred Strains; Morphine; Naltrexone; Nociceptors; Oligopeptides; Quinolines; Receptors, Opioid, delta | 1995 |
NMDA antagonists and clonidine block c-fos expression during morphine withdrawal.
Topics: Animals; Clonidine; Dizocilpine Maleate; Gene Expression; Genes, fos; In Vitro Techniques; Isoquinolines; Male; Morphine; Naltrexone; Neural Pathways; Nucleic Acid Hybridization; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA Probes; RNA, Messenger; Substance Withdrawal Syndrome | 1995 |
mu- and delta-opioid receptor-mediated contractile effects on rat aortic vascular smooth muscle.
Topics: Amino Acid Sequence; Analgesics; Analysis of Variance; Animals; Aorta; Benzomorphans; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Molecular Sequence Data; Morphine; Muscle Contraction; Muscle, Smooth, Vascular; Naltrexone; Norepinephrine; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu | 1995 |
Modification of mu-opioid agonist-induced locomotor activity and development of morphine dependence by diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Mice; Mice, Inbred ICR; Morphine; Morphine Dependence; Motor Activity; Naloxone; Naltrexone; Receptors, Opioid, mu; Streptozocin | 1995 |
Mouse strain differences in in vivo and in vitro immunosuppressive effects of opioids.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Erythrocytes; Female; Immunosuppressive Agents; Mice; Mice, Inbred Strains; Morphine; Naloxone; Naltrexone; Opioid Peptides; Pyrrolidines; Species Specificity; Spleen | 1995 |
Morphine-induced alterations of immune status: dose dependency, compartment specificity and antagonism by naltrexone.
Topics: Animals; Concanavalin A; Dose-Response Relationship, Drug; Immunocompetence; Interferons; Interleukin-2; Killer Cells, Natural; Lymph Nodes; Lymphocytes; Male; Morphine; Naltrexone; Rats; Rats, Inbred Lew; Spleen | 1993 |
Antisense oligodeoxynucleotide to the CCKB receptor produces naltrindole- and [Leu5]enkephalin antiserum-sensitive enhancement of morphine antinociception.
Topics: Animals; Drug Synergism; Enkephalin, Leucine; Immune Sera; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Narcotic Antagonists; Nociceptors; Oligonucleotides, Antisense; Receptors, Cholecystokinin | 1994 |
Involvement of kappa-opioid receptor mechanisms in the calcitonin-induced potentiation of opioid effects at the hypothalamus-pituitary-adrenocortical axis.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Calcitonin; Corticosterone; Drug Synergism; Hypothalamo-Hypophyseal System; Male; Morphine; Naltrexone; Narcotics; Pituitary-Adrenal System; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1994 |
Peripheral kappa-opioid receptors mediate the antinociceptive effect of fedotozine (correction of fetodozine) on the duodenal pain reflex inrat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzyl Compounds; Blood Pressure; Dose-Response Relationship, Drug; Duodenum; Injections, Intravenous; Injections, Intraventricular; Male; Morphine; Naloxone; Naltrexone; Pain; Propylamines; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reflex | 1994 |
Immunologic characterization of TAT72-transgenic mice: effects of morphine on cell-mediated immunity.
Topics: Animals; Gene Products, tat; Immunity, Cellular; Immunosuppressive Agents; Interleukin-2; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Inbred DBA; Mice, Transgenic; Morphine; Naltrexone; Stereoisomerism; T-Lymphocytes, Cytotoxic | 1994 |
The increase in morphine antinociceptive potency produced by carrageenan-induced hindpaw inflammation is blocked by naltrindole, a selective delta-opioid antagonist.
Topics: Animals; Carrageenan; Hindlimb; Inflammation; Male; Morphine; Naltrexone; Nociceptors; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta | 1995 |
A selective CCKB receptor antagonist potentiates, mu-, but not delta-opioid receptor-mediated antinociception in the formalin test.
Topics: Analgesics; Animals; Disulfides; Enkephalins; Formaldehyde; Indoles; Male; Meglumine; Mice; Morphine; Naloxone; Naltrexone; Pain Measurement; Phenylalanine; Receptors, Cholecystokinin; Receptors, Opioid, delta; Receptors, Opioid, mu | 1995 |
Assessment of endogenous enkephalins efficacy in the hot plate test in mice: comparative study with morphine.
Topics: Animals; Dose-Response Relationship, Drug; Enkephalins; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Receptors, Opioid, mu | 1995 |
Pretreatment with beta-funaltrexamine blocks morphine-mediated suppression of CTL activity in alloimmunized mice.
Topics: Animals; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Female; Immunization; In Vitro Techniques; Isoantigens; Killer Cells, Natural; Lymphocyte Activation; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Morphine; Naltrexone; Spleen; T-Lymphocytes, Cytotoxic | 1995 |
Morphine inhibits the development of allogeneic immune responses in mouse lymph node.
Topics: Animals; Graft Survival; Immunity; Isoantigens; Lymph Nodes; Lymphocyte Culture Test, Mixed; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Morphine; Naltrexone; Spleen; T-Lymphocyte Subsets; Transplantation, Homologous | 1995 |
Effects of methylnaltrexone on morphine-induced inhibition of contraction in isolated guinea-pig ileum and human intestine.
Topics: Adult; Aged; Animals; Gastrointestinal Motility; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Intestine, Small; Middle Aged; Morphine; Muscle Contraction; Naloxone; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds | 1995 |
Effect of diabetes on the morphine-induced inhibition of gastrointestinal transit.
Topics: Animals; Depression, Chemical; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Gastrointestinal Transit; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Naltrexone | 1995 |
Effects of diabetes on the morphine-induced Straub tail reaction in mice.
Topics: Animals; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred ICR; Morphine; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu; Reference Values; Tail | 1994 |
Morphine-induced straub tail response: mediated by central mu2-opioid receptor.
Topics: Analgesia; Animals; Female; Injections, Intraventricular; Male; Mice; Morphine; Naloxone; Naltrexone; Receptors, Opioid, mu; Tail | 1994 |
Differing mechanisms for proactive effects of intermittent and single shock on gastric ulceration.
Topics: Animals; Arousal; Dose-Response Relationship, Drug; Electroshock; Gastric Mucosa; Helplessness, Learned; Injections, Subcutaneous; Male; Morphine; Naltrexone; Pain Threshold; Proactive Inhibition; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Stomach Ulcer | 1994 |
Pavlovian conditioning of morphine-induced alterations of immune status: evidence for opioid receptor involvement.
Topics: Animals; Conditioning, Psychological; Interleukin-2; Killer Cells, Natural; Lipopolysaccharides; Lymphocyte Activation; Male; Morphine; Naltrexone; Rats; Rats, Inbred Lew; Receptors, Opioid | 1994 |
Naloxone pretreatment blocks acute morphine-induced sensitization to naltrexone.
Topics: Animals; Conditioning, Operant; Dose-Response Relationship, Drug; Male; Morphine; Naloxone; Naltrexone; Rats; Rats, Sprague-Dawley; Reinforcement Schedule | 1994 |
Repeated acquisition of behavioral chains in squirrel monkeys: comparisons of a mu, kappa and delta opioid agonist.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzamides; Conditioning, Operant; Dose-Response Relationship, Drug; Female; Morphine; Naltrexone; Piperazines; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Saimiri | 1995 |
The effect of chronic treatment with naltrindole, a selective delta-opioid antagonist, on mu-opioid receptor-mediated antinociception in diabetic mice.
Topics: Analgesics; Animals; Diabetes Mellitus, Experimental; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intraventricular; Injections, Subcutaneous; Male; Mice; Mice, Inbred ICR; Monocytes; Morphine; Naltrexone; Narcotic Antagonists; Pain Measurement; Receptors, Opioid, delta; Receptors, Opioid, mu; Spleen | 1993 |
Ultrasounds emitted by female rats during agonistic interactions: effects of morphine and naltrexone.
Topics: Agonistic Behavior; Animals; Dose-Response Relationship, Drug; Estrus; Female; Morphine; Naltrexone; Pain Measurement; Rats; Vocalization, Animal | 1994 |
Blockade of delta-opioid receptors prevents morphine-induced place preference in mice.
Topics: Analgesics; Animals; Benzylidene Compounds; Conditioning, Operant; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Mice, Inbred Strains; Morphine; Naltrexone; Narcotic Antagonists; Oligopeptides; Receptors, Opioid, delta; Receptors, Opioid, mu | 1994 |
Antagonism of the morphine-induced Straub tail reaction by kappa-opioid receptor activation in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Dose-Response Relationship, Drug; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Morphine; Naltrexone; Narcotic Antagonists; Pain Measurement; Pyrrolidines; Receptors, Opioid, kappa | 1993 |
Involvement of delta-opioid receptors in the effects of morphine on locomotor activity and the mesolimbic dopaminergic system in mice.
Topics: 3,4-Dihydroxyphenylacetic Acid; Analgesics; Animals; Dopamine; Homovanillic Acid; Limbic System; Male; Mice; Mice, Inbred Strains; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Postural Balance; Reaction Time; Receptors, Opioid, delta | 1993 |
Mechanisms of morphine-induced immunosuppression: effect of acute morphine administration on lymphocyte trafficking.
Topics: Adrenalectomy; Animals; Cell Movement; Fentanyl; Immunosuppression Therapy; Leukocyte Count; Lymphocyte Activation; Lymphocyte Count; Lymphocytes; Male; Morphine; Naltrexone; Rats; Rats, Sprague-Dawley; T-Lymphocyte Subsets | 1995 |
Naltrindole, an opioid delta antagonist, blocks the enhancement of morphine-antinociception induced by a CCKB antagonist in the rat.
Topics: Animals; Benzodiazepinones; Injections, Spinal; Injections, Subcutaneous; Male; Morphine; Naltrexone; Narcotic Antagonists; Nociceptors; Pain Measurement; Phenylurea Compounds; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Receptors, Opioid, delta | 1994 |
Inhibiting a spinal dynorphin A component enhances intrathecal morphine antinociception in mice.
Topics: Analgesics; Animals; Cerebral Ventricles; Dynorphins; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Spine | 1993 |
Dynorphin A(1-17) mediates midazolam antagonism of morphine antinociception in mice.
Topics: Analgesics; Animals; Clonidine; Dose-Response Relationship, Drug; Dynorphins; GABA Antagonists; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Midazolam; Morphine; Naloxone; Naltrexone; Pain Measurement; Reaction Time; Spinal Cord | 1993 |
Blockade of morphine reward through the activation of kappa-opioid receptors in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; 3,4-Dihydroxyphenylacetic Acid; Analgesics; Animals; Apomorphine; Conditioning, Operant; Dopamine; Dynorphins; Homovanillic Acid; Injections, Subcutaneous; Limbic System; Male; Mice; Mice, Inbred Strains; Morphine; Motivation; Naltrexone; Peptide Fragments; Prosencephalon; Pyrrolidines; Receptors, Opioid, kappa; Reward | 1993 |
Effects of mu, delta and kappa opioid antagonists on the depression of a C-fiber reflex by intrathecal morphine and DAGO in the rat.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Spinal; Morphine; Naltrexone; Narcotic Antagonists; Nerve Fibers; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reflex; Somatostatin | 1994 |
Pharmacological characterization of dynorphin A (1-17)-induced effects on spinal cord-evoked potentials.
Topics: Animals; Drug Interactions; Dynorphins; Evoked Potentials; Ganglia, Spinal; Male; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Spinal Cord | 1994 |
Receptor-mediated regulation of neuropeptide gene expression in astrocytes.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Astrocytes; Benzomorphans; Brain; Enkephalin, Methionine; Etorphine; Gene Expression Regulation; Morphine; Naltrexone; Nerve Tissue Proteins; Neuropeptides; Organ Specificity; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; Receptors, Opioid | 1994 |
Opioids inhibit endothelin-mediated DNA synthesis, phosphoinositide turnover, and Ca2+ mobilization in rat C6 glioma cells.
Topics: Animals; Antibodies, Anti-Idiotypic; beta-Endorphin; Calcium; Desipramine; DNA, Neoplasm; Dose-Response Relationship, Drug; Endothelins; Glioma; Morphine; Naltrexone; Phosphatidylinositols; Rats; Receptors, Opioid; Thymidine; Tumor Cells, Cultured | 1994 |
A mechanism of action for morphine-induced immunosuppression: corticosterone mediates morphine-induced suppression of natural killer cell activity.
Topics: Animals; Cells, Cultured; Corticosterone; Female; Immunosuppressive Agents; Killer Cells, Natural; Mice; Morphine; Naloxone; Naltrexone; Receptors, Opioid; Spleen | 1994 |
The involvement of opioid delta receptor in restraint-induced antinociception in mice.
Topics: Animals; Female; Male; Mice; Mice, Inbred CFTR; Morphine; Naltrexone; Narcotic Antagonists; Nociceptors; Pain Measurement; Receptors, Opioid, delta; Receptors, Opioid, mu; Restraint, Physical; Sex Factors | 1994 |
Participation of opioid receptor types on post-tetanic twitch inhibition in isolated guinea-pig ileal longitudinal muscle.
Topics: Amino Acid Sequence; Animals; Dynorphins; Electric Stimulation; Enkephalin, Leucine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Molecular Sequence Data; Morphine; Muscle Contraction; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Narcotics; Peptide Fragments; Receptors, Opioid | 1994 |
In vivo apparent pA2 analysis for naltrexone antagonism of discriminative stimulus and analgesic effects of opiate agonists in rats.
Topics: Analgesia; Animals; Benzomorphans; Buprenorphine; Discrimination, Psychological; Etorphine; Fentanyl; Male; Morphine; Nalbuphine; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1994 |
Morphine reduces the release of met-enkephalin-like material from the rat spinal cord in vivo by acting at delta opioid receptors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Injections, Spinal; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pyrrolidines; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Spinal Cord | 1994 |
The effect of chronic naltrexone pretreatment on associative vs. non-associative morphine tolerance.
Topics: Animals; Association Learning; Conditioning, Classical; Male; Morphine; Naltrexone; Pain Threshold; Premedication; Rats; Rats, Sprague-Dawley; Reaction Time | 1994 |
Antinociceptive and response rate-altering effects of kappa opioid agonists, spiradoline, enadoline and U69,593, alone and in combination with opioid antagonists in squirrel monkeys.
Topics: Analgesics; Animals; Azocines; Benzeneacetamides; Benzofurans; Dose-Response Relationship, Drug; Male; Morphine; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid, kappa; Saimiri | 1994 |
Morphine-induced decreases in in vivo antibody responses.
Topics: Animals; Antibody Formation; Hydrocortisone; Immunologic Deficiency Syndromes; Male; Morphine; Naltrexone; Neuroimmunomodulation; Rats; Rats, Inbred F344; Rats, Sprague-Dawley | 1994 |
Streptozotocin-induced diabetes selectively reduces antinociception mediated by mu 1-opioid receptors, but not that mediated by mu 2-opioid receptors.
Topics: Analgesics; Animals; Diabetes Mellitus, Experimental; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Receptors, Opioid, mu; Spinal Cord | 1994 |
Opioid receptor agonist potencies of morphine and morphine-6-glucuronide in the guinea-pig ileum.
Topics: Amino Acid Sequence; Animals; Electric Stimulation; Guinea Pigs; Ileum; In Vitro Techniques; Male; Molecular Sequence Data; Morphine; Morphine Derivatives; Muscle Contraction; Muscle, Smooth; Naltrexone; Peptide Fragments; Peptides; Receptors, Opioid; Receptors, Opioid, mu; Somatostatin | 1994 |
Effects of naltrexone pellet implantation on morphine tolerance and physical dependence in the rat.
Topics: Analgesia; Animals; Body Temperature; Dose-Response Relationship, Drug; Drug Implants; Drug Interactions; Drug Tolerance; Male; Morphine; Naltrexone; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors; Weight Loss | 1994 |
Effect of morphine tolerance and abstinence on the binding of [3H]naltrexone to discrete brain regions and spinal cord of the rat.
Topics: Analgesics; Animals; Brain; Drug Implants; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Membranes; Morphine; Morphine Dependence; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, mu; Spinal Cord; Substance Withdrawal Syndrome | 1994 |
Lack of involvement of delta-1 opioid receptors in the development of physical dependence on morphine in mice.
Topics: Affinity Labels; Animals; Diarrhea; Enkephalin, Leucine-2-Alanine; Injections, Intraventricular; Injections, Spinal; Isothiocyanates; Male; Mice; Morphine; Naloxone; Naltrexone; Receptors, Opioid, delta; Substance-Related Disorders | 1994 |
Role of vagal afferents in the antinociception produced by morphine and U-50,488H in the colonic pain reflex in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Blood Pressure; Colon; Injections, Intraventricular; Injections, Spinal; Male; Morphine; Naloxone; Naltrexone; Neurons, Afferent; Pain; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reflex; Vagotomy; Vagus Nerve | 1994 |
The use of specific opioid agonists and antagonists to delineate the vagally mediated antinociceptive and cardiovascular effects of intravenous morphine.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analysis of Variance; Animals; Blood Pressure; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Heart Rate; Hexamethonium; Hexamethonium Compounds; Indoles; Injections, Intravenous; Male; Morphinans; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pain; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reference Values; Time Factors; Vagotomy; Vagus Nerve | 1993 |
Opioid antagonists: indirect antagonism of morphine analgesia by spinal dynorphin A.
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Dynorphins; Injections, Intraventricular; Injections, Spinal; Levallorphan; Male; Mice; Mice, Inbred ICR; Morphine; Nalbuphine; Naltrexone; Nociceptors; Spinal Cord | 1993 |
Effects of naltrexone on the binding of [3H]D-Ala2, MePhe4, Gly-ol5-enkephalin to brain regions and spinal cord and pharmacological responses to morphine in the rat.
Topics: Analgesics; Animals; Body Temperature; Brain; Drug Implants; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Morphine; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Spinal Cord; Up-Regulation | 1993 |
Hyperalgesic and analgesic actions of morphine, U50-488, naltrexone, and (-)-lobeline in the rat brainstem.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Dose-Response Relationship, Drug; Female; Lobeline; Microinjections; Morphine; Naltrexone; Pain; Pain Measurement; Pyrrolidines; Rats; Rats, Sprague-Dawley; Tegmentum Mesencephali | 1994 |
The nature of conditioned anti-analgesia: spinal cord opiate and anti-opiate neurochemistry.
Topics: Analgesia; Analgesics; Animals; Conditioning, Classical; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Immune Sera; Injections, Spinal; Male; Morphine; Naltrexone; Narcotic Antagonists; Oligopeptides; Proglumide; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Spinal Cord | 1994 |
mu-Opioid receptors modulate noradrenaline release from the rat hippocampus as measured by brain microdialysis.
Topics: Analgesics; Animals; Benzeneacetamides; Chromatography, High Pressure Liquid; Desipramine; Electrochemistry; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Extracellular Space; GTP-Binding Proteins; Hippocampus; Male; Microdialysis; Morphine; Naltrexone; Nerve Endings; Norepinephrine; Potassium; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, mu; Virulence Factors, Bordetella | 1994 |
Serum prolactin response to ether stress in diabetic rats: opiate system contribution.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Ether; Male; Morphine; Naltrexone; Narcotic Antagonists; Prolactin; Rats; Rats, Wistar; Receptors, Opioid; Stress, Physiological | 1994 |
Opioids and corticosteroids involvement in the regulation of the neocortical spindling episodes in DBA/2J mice.
Topics: Adrenal Cortex; Animals; Cerebral Cortex; Corticosterone; Cycloheximide; Dexamethasone; Disease Models, Animal; Disease Susceptibility; Electroencephalography; Epilepsy; Genetic Predisposition to Disease; Male; Mice; Mice, Inbred DBA; Mifepristone; Morphine; Naltrexone | 1993 |
Area tempestas modulates the behavioural responses to nociceptive stimuli in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Anticonvulsants; Azocines; Bicuculline; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Escape Reaction; Foot; Hot Temperature; Male; Morphine; Naltrexone; Narcotic Antagonists; Olfactory Pathways; Pain; Phenazocine; Pressure; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid; Seizures; Tail | 1993 |
Antagonistic effects of the selective, competitive N-methyl-D-aspartate (NMDA) receptor antagonist, NPC 12626, on kappa opiate-induced analgesia in male deer mice.
Topics: Amino Acids; Analgesics; Animals; Benzeneacetamides; Dizocilpine Maleate; Dose-Response Relationship, Drug; Male; Morphine; Naloxone; Naltrexone; Nociceptors; Pain Measurement; Peromyscus; Pyrrolidines; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa | 1994 |
Naltrexone antagonizes the analgesic and immunosuppressive effects of morphine in mice.
Topics: Animals; Dose-Response Relationship, Drug; Immunosuppressive Agents; Killer Cells, Natural; Male; Mice; Morphine; Naltrexone; Pain Measurement; Spleen; Tumor Cells, Cultured | 1994 |
Amphetamine-induced modification of quinine palatability: analysis by the taste reactivity test.
Topics: Animals; Dextroamphetamine; Drinking Behavior; Male; Morphine; Motor Activity; Naltrexone; Pimozide; Quinine; Rats; Rats, Sprague-Dawley; Sucrose; Taste | 1994 |
Acute sensitization to opioid antagonists.
Topics: Animals; Conditioning, Operant; Dose-Response Relationship, Drug; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Reinforcement Schedule; Stereoisomerism | 1994 |
Antinociceptive effect of dihydroetorphine and its tolerance/dependence liability in mice.
Topics: Analgesics; Animals; Body Weight; Drug Tolerance; Etorphine; Male; Mice; Mice, Inbred Strains; Morphine; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Substance-Related Disorders | 1993 |
Restraint stress potentiates analgesia induced by 5'-N-ethylcarboxamidoadenosine: comparison with morphine.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Analgesia; Animals; Caffeine; Dose-Response Relationship, Drug; Drug Interactions; Male; Morphine; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Restraint, Physical; Stress, Physiological | 1993 |
Antinociceptive activity of intrathecal ketorolac is blocked by the kappa-opioid receptor antagonist, nor-binaltorphimine.
Topics: Analgesics; Animals; Drug Interactions; Drug Tolerance; Injections, Spinal; Ketorolac; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Pain; Receptors, Opioid, kappa; Tolmetin | 1993 |
Hepatic and splenic phagocytosis in female B6C3F1 mice implanted with morphine sulfate pellets.
Topics: Animals; Drug Tolerance; Female; Kupffer Cells; Liver; Macrophages; Mice; Mice, Inbred Strains; Mifepristone; Mononuclear Phagocyte System; Morphine; Naltrexone; Organ Size; Phagocytosis; Spleen | 1993 |
Discriminative stimulus effects of BW373U86: a nonpeptide ligand with selectivity for delta opioid receptors.
Topics: Amino Acid Sequence; Analgesics; Animals; Benzamides; Benzomorphans; Columbidae; Discrimination Learning; Enkephalin, Leucine; Molecular Sequence Data; Morphine; Naltrexone; Narcotic Antagonists; Piperazines; Receptors, Opioid, delta; Receptors, Opioid, mu | 1993 |
Possible contribution of a glutathione conjugate to the long-duration action of beta-funaltrexamine.
Topics: Analgesia; Animals; Enkephalin, Leucine-2-Alanine; Glutathione; Guinea Pigs; Kinetics; Male; Mice; Morphine; Muscles; Naltrexone; Receptors, Opioid, mu; Structure-Activity Relationship; Vas Deferens | 1993 |
Medullary mu and delta opioid receptors modulate mesencephalic morphine analgesia in rats.
Topics: Analgesics; Animals; Male; Medulla Oblongata; Mesencephalon; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu | 1993 |
Opioidergic manipulations affect intake of 3% NaCl in sodium-deficient rats.
Topics: Animals; Body Weight; Drinking Behavior; Furosemide; Male; Morphine; Naltrexone; Narcotics; Rats; Rats, Sprague-Dawley; Sodium; Sodium Chloride, Dietary | 1993 |
Opioid antagonist-induced receptor upregulation: effects of concurrent agonist administration.
Topics: Animals; Brain; Drug Combinations; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Fentanyl; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu; Up-Regulation | 1994 |
A monoclonal anti-idiotypic antibody to opioid receptors labels desipramine-induced opioid binding sites on rat C6 glioma cells and attenuates thymidine incorporation into DNA.
Topics: Animals; Antibodies, Monoclonal; Brain Neoplasms; Cell Division; Cell Membrane; Colorimetry; Densitometry; Desipramine; DNA, Neoplasm; Glioma; Immunohistochemistry; Morphine; Naltrexone; Pertussis Toxin; Rats; Receptors, Opioid; Thymidine; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1994 |
Naltrexone in vivo protects mu receptors from inactivation by beta-funaltrexamine, but not kappa receptors from inactivation by nor-binaltorphimine.
Topics: Analgesics; Animals; Benzeneacetamides; Cisterna Magna; Dose-Response Relationship, Drug; Injections; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain Measurement; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1993 |
Opioid modulation of amphetamine-stimulated dopamine release and concentration in rat striatal slices.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amphetamine; Animals; Dihydroxyphenylalanine; Dopamine; Hydrazines; In Vitro Techniques; Male; Morphine; Naltrexone; Narcotics; Neostriatum; Rats; Rats, Sprague-Dawley | 1993 |
Morphine treatment in vitro or in vivo decreases phagocytic functions of murine macrophages.
Topics: Animals; Candida albicans; Depression, Chemical; Drug Interactions; Female; Macrophages; Mice; Mice, Inbred C3H; Morphine; Naltrexone; Peritoneal Cavity; Phagocytosis; Time Factors | 1993 |
Prostaglandin E2-induced thermal hyperalgesia and its reversal by morphine in the warm-water tail-withdrawal procedure in rhesus monkeys.
Topics: Animals; Azocines; Data Interpretation, Statistical; Dinoprostone; Dose-Response Relationship, Drug; Female; Hot Temperature; Hyperalgesia; Macaca mulatta; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain Measurement; Sodium Chloride; Temperature | 1993 |
Modification of morphine-induced locomotor activity by pertussis toxin: biochemical and behavioral studies in mice.
Topics: Analgesics; Analysis of Variance; Animals; Cerebral Ventricles; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intraventricular; Injections, Subcutaneous; Kinetics; Male; Mice; Mice, Inbred Strains; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Pertussis Toxin; Time Factors; Virulence Factors, Bordetella | 1993 |
Electrophysiological actions of delta opioids in CA1 of the rat hippocampal slice are mediated by one delta receptor subtype.
Topics: Analgesics; Animals; Electric Stimulation; Electrophysiology; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Evoked Potentials; Hippocampus; In Vitro Techniques; Indoles; Ligands; Male; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Pyramidal Tracts; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu | 1993 |
The kappa opioid agonist U-50,488H antagonizes respiratory effects of mu opioid receptor agonists in conscious rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Morphine; Naltrexone; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Respiration | 1993 |
Effects of opiates on neuronal development in the rat cerebral cortex.
Topics: Animals; Body Weight; Cerebral Cortex; Female; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Neurons; Pregnancy; Rats; Rats, Sprague-Dawley; Somatosensory Cortex | 1993 |
Independent expression of two pharmacologically distinct supraspinal mu analgesic systems in genetically different mouse strains.
Topics: Analgesia; Animals; Brain Stem; Drug Administration Routes; Male; Mice; Morphine; Naloxone; Naltrexone; Receptors, Opioid, mu; Species Specificity; Spinal Cord | 1993 |
Effects of the kappa-opioid agonist U50,488 on parturition in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Female; Infusions, Intravenous; Injections, Intravenous; Labor, Obstetric; Male; Morphine; Naloxone; Naltrexone; Oxytocin; Pregnancy; Pyrrolidines; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Opioid, kappa; Uterine Contraction | 1993 |
Withdrawal contractures of guinea-pig isolated ileum after acute activation of kappa-opioid receptors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Clonidine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Nifedipine; Pyrrolidines; Receptors, Opioid, kappa; Substance Withdrawal Syndrome | 1993 |
Chronic exposure to morphine and naltrexone induces changes in catecholaminergic neurotransmission in rat brain without altering mu-opioid receptor sensitivity.
Topics: Adenylyl Cyclases; Animals; Binding Sites; Brain; Catecholamines; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Morphine; Naltrexone; Norepinephrine; Radioligand Assay; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Opioid, mu | 1993 |
Opioid control of the release of calcitonin gene-related peptide-like material from the rat spinal cord in vivo.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Calcitonin Gene-Related Peptide; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Spinal; Iodine Radioisotopes; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pyrrolidines; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1993 |
Involvement of delta 2 opioid receptors in acute dependence on morphine in mice.
Topics: Animals; Drug Interactions; Enkephalin, Leucine; Isothiocyanates; Male; Mice; Morphine; Naltrexone; Receptors, Opioid, delta; Substance-Related Disorders; Thiocyanates | 1993 |
Dose-dependent antagonism of spinal opioid receptor agonists by naloxone and naltrindole: additional evidence for delta-opioid receptor subtypes in the rat.
Topics: Analgesics; Animals; Binding, Competitive; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; In Vitro Techniques; Injections, Spinal; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord | 1993 |
Modulation of morphine-induced sensitization by endogenous kappa opioid systems in the rat.
Topics: Animals; Dialysis; Dopamine; Injections, Intraventricular; Limbic System; Male; Morphine; Motor Activity; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa | 1993 |
Opioid-induced suppression of rat testicular function.
Topics: Animals; Dose-Response Relationship, Drug; Drug Interactions; Endorphins; Extracellular Space; Gonadotropins; Hypothalamo-Hypophyseal System; Luteinizing Hormone; Male; Morphine; Naloxone; Naltrexone; Pituitary-Adrenal System; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Testis; Testosterone; Time Factors | 1993 |
The highly selective delta agonist BUBU induces an analgesic effect in normal and arthritic rat and this action is not affected by repeated administration of low doses of morphine.
Topics: Analgesics; Animals; Arthritis, Experimental; Drug Administration Schedule; Drug Interactions; Enkephalins; Male; Morphine; Naloxone; Naltrexone; Oligopeptides; Pain; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Reference Values; Vocalization, Animal | 1993 |
Involvement of spinal kappa opioid receptors in a type of footshock induced analgesia in mice.
Topics: Analgesia; Animals; Cerebral Ventricles; Electroshock; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Receptors, Opioid, kappa; Spinal Cord; Stress, Psychological | 1993 |
Effects of kappa-agonist on the antinociception and locomotor enhancing action induced by morphine in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzylamines; Dopamine; Dose-Response Relationship, Drug; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Narcotics; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sympathomimetics | 1993 |
Opioid receptor regulation of 5-hydroxytryptamine release from the rat hippocampus measured by in vivo microdialysis.
Topics: Analgesics; Animals; Benzeneacetamides; Dialysis; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hippocampus; Male; Micromanipulation; Morphine; Naltrexone; Potassium; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid; Serotonin | 1993 |
Selective and interactive down-regulation of mu- and delta-opioid receptors in human neuroblastoma SK-N-SH cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Down-Regulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Humans; Morphine; Naltrexone; Neuroblastoma; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, mu; Tumor Cells, Cultured | 1993 |
Antitussive effects of mu- and kappa-agonists in diabetic rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Antitussive Agents; Diabetes Mellitus, Experimental; Male; Morphine; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1993 |
Role of mu 1- and delta-opioid receptors in modulation of fetal EEG and respiratory activity.
Topics: Animals; Electroencephalography; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fetal Movement; Fetus; Morphine; Naloxone; Naltrexone; Receptors, Opioid, delta; Receptors, Opioid, mu; Respiration; Sheep | 1993 |
Isobolographic superadditivity between delta and mu opioid agonists in the rat depends on the ratio of compounds, the mu agonist and the analgesic assay used.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Synergism; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Morphine; Naltrexone; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu | 1993 |
Evidence for the up-regulation of kappa opiate mechanisms in mice selectively bred for high analgesia.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics; Animals; Female; Mice; Morphine; Naltrexone; Pyrrolidines; Receptors, Opioid, kappa; Stress, Psychological; Swimming; Up-Regulation | 1993 |
Dose-related antagonism of the emetic effect of morphine by methylnaltrexone in dogs.
Topics: Animals; Dogs; Dose-Response Relationship, Drug; Injections, Intramuscular; Injections, Intravenous; Male; Morphine; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Vomiting | 1993 |
Morphine inhibits calcium influx and the response to acetylcholine in Xenopus oocytes.
Topics: Acetylcholine; Animals; Calcium; Diprenorphine; Electrophysiology; Female; Morphine; Muscarine; Naltrexone; Oocytes; Radioligand Assay; Xenopus laevis | 1993 |
Effects of in vivo morphine treatment on antibody responses in C57BL/6 bgJ/bgJ (beige) mice.
Topics: Animals; Antibody Formation; Hemolytic Plaque Technique; Immunologic Deficiency Syndromes; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Morphine; Naltrexone | 1993 |
Effects of naltrexone on pharmacodynamics and pharmacokinetics of intravenously administered morphine in the rat.
Topics: Animals; Body Temperature Regulation; Injections, Intravenous; Male; Morphine; Naltrexone; Rats; Rats, Sprague-Dawley | 1993 |
Influence of hyperkalaemia and ischaemia on non-receptor-mediated cardiac electrophysiological effects of naloxone.
Topics: Action Potentials; Animals; Culture Techniques; Dose-Response Relationship, Drug; Electrophysiology; Heart Conduction System; Hyperkalemia; Morphine; Myocardial Ischemia; Naloxone; Naltrexone; Narcotic Antagonists; Rabbits; Refractory Period, Electrophysiological | 1993 |
Morphine-induced alterations in thymocyte subpopulations of B6C3F1 mice.
Topics: Animals; CD4-CD8 Ratio; Cell Death; Female; Flow Cytometry; Lymphocyte Subsets; Mice; Morphine; Naltrexone; Organ Size; Thymus Gland | 1993 |
Perinatal morphine treatment inhibits pruning effect and regeneration of serotoninergic pathways following neonatal 5,7-HT lesions.
Topics: 5,7-Dihydroxytryptamine; Animals; Animals, Newborn; Brain Chemistry; Cerebral Cortex; Chromatography, High Pressure Liquid; Female; Hypothalamus; Immunohistochemistry; In Situ Hybridization; Morphine; Naltrexone; Nerve Regeneration; Neural Pathways; Neuronal Plasticity; Pregnancy; Rats; Rats, Sprague-Dawley; Serotonin; Spinal Cord; Sulfur Radioisotopes | 1993 |
Naltrexone-induced alterations of the distribution of morphine in brain regions and spinal cord of the rat.
Topics: Analgesics; Animals; Body Temperature; Brain; Dose-Response Relationship, Drug; Half-Life; Injections, Intravenous; Male; Morphine; Naltrexone; Pain Measurement; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Spinal Cord | 1993 |
Opioid and nonopioid interactions in two forms of stress-induced analgesia.
Topics: Analgesia; Animals; Body Temperature; Cold Temperature; Male; Morphine; Naloxone; Naltrexone; Rats; Rats, Sprague-Dawley; Reaction Time; Skin Temperature; Social Behavior; Stress, Psychological | 1993 |
Discriminative stimulus properties of morphine mediated by mu 1-opioid receptors.
Topics: Analgesics, Opioid; Animals; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred F344; Receptors, Opioid, mu | 1995 |
Biochemical and pharmacological characterization of multiple beta-endorphinergic antinociceptive systems in the rat periaqueductal gray.
Topics: Amino Acid Sequence; Animals; beta-Endorphin; Dose-Response Relationship, Drug; Drug Interactions; Iodine Radioisotopes; Male; Molecular Sequence Data; Morphine; Naltrexone; Narcotic Antagonists; Nociceptors; Opioid Peptides; Peptide Fragments; Periaqueductal Gray; Radioligand Assay; Rats; Rats, Sprague-Dawley; Somatostatin | 1996 |
Effects of chronic opiate and opioid antagonist treatment on striatal opioid peptides.
Topics: Amino Acid Sequence; Animals; Corpus Striatum; Endorphins; Feedback; Male; Molecular Sequence Data; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Neuropeptides; Rats; Rats, Sprague-Dawley; Substantia Nigra | 1995 |
Morphine affects cytostatic activity of macrophages by the modulation of nitric oxide release.
Topics: Analgesics, Opioid; Animals; Dexamethasone; Macrophages; Male; Mice; Mice, Inbred C57BL; Morphine; Naltrexone; Nitric Oxide; Time Factors | 1995 |
A study of reversibly inactivated lipases for use in a morphine-triggered naltrexone delivery system.
Topics: Animals; Chromobacterium; Conjugation, Genetic; Drug Implants; Enzyme Activation; Enzyme-Linked Immunosorbent Assay; Immunoconjugates; Lipase; Lipoprotein Lipase; Morphine; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Narcotics; Radioimmunoassay | 1995 |
Differential effects of intrahypothalamic administration of opioids on food intake in naive and tolerant rats.
Topics: Animals; Eating; Ethylketocyclazocine; Hypothalamus; Male; Morphine; Naltrexone; Narcotics; Rats; Rats, Wistar; Time Factors | 1995 |
Biocompatibility and in vivo morphine diffusion into a placebo morphine-triggered naltrexone delivery device in rabbits.
Topics: Animals; Biocompatible Materials; Biotransformation; Female; Heroin Dependence; Infusion Pumps, Implantable; Injections, Intravenous; Materials Testing; Morphine; Naltrexone; Rabbits | 1995 |
Induction of chronic Fos-related antigens in rat brain by chronic morphine administration.
Topics: Animals; Blotting, Western; Brain; DNA-Binding Proteins; Fos-Related Antigen-2; Male; Morphine; Naltrexone; Narcotics; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Transcription Factor AP-1; Transcription Factors | 1996 |
Assessment of the involvement of central nervous system and peripheral opioid receptors in the immunomodulatory effects of acute morphine treatment in rats.
Topics: Analgesics, Opioid; Animals; Brain; Dose-Response Relationship, Drug; Immunity; Killer Cells, Natural; Lymphocyte Activation; Male; Morphine; Naltrexone; Rats; Rats, Inbred F344; Receptors, Opioid; Spleen | 1996 |
Interaction of opioids with antidepressant-induced antinociception.
Topics: Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Clomipramine; Drug Combinations; Female; Imipramine; Male; Maprotiline; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pain Measurement; Random Allocation; Selective Serotonin Reuptake Inhibitors; Zimeldine | 1995 |
Effects of nitric oxide-related agents on opioid regulation of rat testicular steroidogenesis.
Topics: Animals; Arginine; Chorionic Gonadotropin; Enzyme Inhibitors; Isosorbide Dinitrate; Male; Morphine; Naltrexone; Narcotic Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Testis; Testosterone | 1996 |
Spinal cord mechanisms of opioid tolerance and dependence: Fos-like immunoreactivity increases in subpopulations of spinal cord neurons during withdrawal [corrected].
Topics: Analgesics, Opioid; Animals; Drug Implants; Drug Tolerance; Male; Morphine; Naltrexone; Narcotic Antagonists; Neurons; Opioid-Related Disorders; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance Withdrawal Syndrome | 1996 |
The isolation and companion comfort responses of 7- and 3-day-old rat pups are modulated by drugs active at the opioid receptor.
Topics: Age Factors; Animals; Animals, Newborn; Arousal; Dose-Response Relationship, Drug; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid; Social Behavior; Social Isolation; Vocalization, Animal | 1996 |
Differential effects of morphine-6-glucuronide, an active metabolite of morphine, and morphine on locomotor activity in mice: involvement of the opioid receptor.
Topics: Animals; Injections, Subcutaneous; Locomotion; Male; Mice; Mice, Inbred Strains; Morphine; Morphine Derivatives; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid | 1996 |
Distribution of c-Fos in guinea-pig brain following morphine withdrawal.
Topics: Analgesics, Opioid; Animals; Brain Chemistry; Female; Guinea Pigs; Locomotion; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Proto-Oncogene Proteins c-fos; Substance Withdrawal Syndrome | 1996 |
Role of delta-opioid receptors in mediating the aversive stimulus effects of morphine withdrawal in the rat.
Topics: Animals; Dose-Response Relationship, Drug; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Substance Withdrawal Syndrome | 1996 |
Antinociceptive and antitussive effects of morphine in the DA-bg/bg (beige) rat.
Topics: Analgesics, Opioid; Animals; Capsaicin; Cough; Female; Male; Morphine; Naloxone; Naltrexone; Pain; Rats; Rats, Inbred Strains; Species Specificity | 1996 |
Morphine stimulates phagocytosis of Mycobacterium tuberculosis by human microglial cells: involvement of a G protein-coupled opiate receptor.
Topics: Adjuvants, Immunologic; Brain; Cells, Cultured; Cholera Toxin; GTP-Binding Proteins; Humans; Microglia; Morphine; Mycobacterium tuberculosis; Naloxone; Naltrexone; Narcotic Antagonists; Neuroimmunomodulation; Pertussis Toxin; Phagocytosis; Receptors, Opioid; Signal Transduction; Virulence Factors, Bordetella | 1995 |
Ontogeny of morphine withdrawal in the rat.
Topics: Age Factors; Animals; Arousal; Female; Humans; Infant, Newborn; Injections, Intraperitoneal; Male; Morphine; Morphine Dependence; Motor Activity; Naltrexone; Narcotic Antagonists; Neonatal Abstinence Syndrome; Neurologic Examination; Rats; Substance Withdrawal Syndrome | 1995 |
Morphine suppresses the alloantigen-driven CTL response in a dose-dependent and naltrexone reversible manner.
Topics: Animals; Dose-Response Relationship, Drug; Isoantigens; Lymphocytes; Mice; Mice, Inbred Strains; Morphine; Naltrexone; RNA | 1996 |
Opioid antagonist profile of SC nor-binaltorphimine in the formalin paw assay.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Formaldehyde; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Pyrroles; Pyrrolidines; Receptors, Opioid, kappa; Receptors, Opioid, mu; Thiophenes | 1996 |
Preprothyrotropin-releasing hormone mRNA in the rat central gray is strongly and persistently induced during morphine withdrawal.
Topics: Analgesics, Opioid; Animals; Brain; In Situ Hybridization; Male; Mesencephalon; Morphine; Naltrexone; Narcotic Antagonists; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Substance Withdrawal Syndrome; Thalamus; Thyrotropin-Releasing Hormone; Up-Regulation | 1996 |
Role of opioid receptors in the spinal antinociceptive effects of neuropeptide FF analogues.
Topics: Amino Acid Sequence; Analgesics; Analgesics, Opioid; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Spinal; Male; Molecular Sequence Data; Morphine; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Somatostatin; Spinal Cord | 1996 |
Mu- and delta-opioid receptor antagonists precipitate similar withdrawal phenomena in butorphanol and morphine dependence.
Topics: Animals; Butorphanol; Drug Evaluation, Preclinical; Injections, Intraventricular; Locus Coeruleus; Male; Morphine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Somatostatin; Substance Withdrawal Syndrome | 1996 |
Involvement of beta-endorphin in the modulation of paw inflammatory edema in the rat.
Topics: Animals; Antibodies; Benzomorphans; beta-Endorphin; Edema; Enkephalin, Leucine; Foot; Inflammation; Male; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Yeasts | 1996 |
Effects of methylnaltrexone on morphine-induced cough suppression in guinea pigs.
Topics: Analgesia; Animals; Antitussive Agents; Guinea Pigs; Male; Morphine; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds | 1996 |
Opiate systems in mother and infant primates coordinate intimate contact during reunion.
Topics: Animals; Endorphins; Female; Macaca mulatta; Maternal Behavior; Maternal Deprivation; Morphine; Naltrexone; Narcotic Antagonists; Narcotics | 1995 |
The cocaine-like behavioral effects of meperidine are mediated by activity at the dopamine transporter.
Topics: Animals; Behavior, Animal; Carrier Proteins; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Male; Membrane Glycoproteins; Membrane Transport Proteins; Meperidine; Models, Molecular; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Nerve Tissue Proteins; Rats; Rats, Sprague-Dawley; Saimiri | 1996 |
Effect of the highly selective and nonpeptide delta opioid receptor agonist TAN-67 on the morphine-induced place preference in mice.
Topics: Analgesics; Animals; Benzylidene Compounds; Dopamine; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Limbic System; Male; Mice; Morphine; Naltrexone; Quinolines; Receptors, Opioid, delta; Reward | 1996 |
Opiate withdrawal increases ProTRH gene expression in the ventrolateral column of the midbrain periaqueductal gray.
Topics: Animals; Gene Expression Regulation; Immunohistochemistry; In Situ Hybridization; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Neurons; Periaqueductal Gray; Protein Precursors; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Thyrotropin-Releasing Hormone | 1996 |
Effects of the delta opioid against BW373U86 in pigeons trained to discriminate fentanyl, bremazocine and water in a three-choice drug discrimination procedure.
Topics: Analgesics; Animals; Benzamides; Benzomorphans; Columbidae; Discrimination, Psychological; Female; Fentanyl; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Piperazines; Receptors, Opioid, delta | 1996 |
The NMDA receptor antagonist MK-801 differentially modulates mu and kappa opioid actions in spinal cord in vitro.
Topics: Analgesics; Animals; Animals, Newborn; Benzeneacetamides; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; In Vitro Techniques; Membrane Potentials; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1996 |
Induction of Fos-like immunoreactivity by opioids in guinea-pig brain.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Opioid; Animals; Brain Chemistry; Diencephalon; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Guinea Pigs; Immunohistochemistry; Injections, Intraventricular; Male; Mesencephalon; Morphine; Naltrexone; Narcotic Antagonists; Neurons; Proto-Oncogene Proteins c-fos; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Telencephalon | 1996 |
Effects of selective opioid receptor antagonists on morphine-induced changes in striatal and limbic dopamine metabolism.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Dopamine; Homovanillic Acid; Injections, Intraperitoneal; Injections, Intraventricular; Limbic System; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pain Threshold; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu | 1995 |
The effects of morphine on carrageenin-induced spinal c-Fos expression are completely blocked by beta-funaltrexamine, a selective mu-opioid receptor antagonist.
Topics: Animals; Carrageenan; Gene Expression; Male; Morphine; Naltrexone; Narcotic Antagonists; Neurons; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Spinal Cord | 1996 |
Sensitization of the tail-flick reflex following exposure to either a single prolonged test trial or behavioral testing under the analgesic influence of morphine.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Body Temperature; Hot Temperature; Hyperalgesia; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain Threshold; Physical Stimulation; Rats; Rats, Sprague-Dawley; Reaction Time; Reflex; Restraint, Physical; Tail; Time Factors | 1996 |
A selective AMPA antagonist, LY293558, suppresses morphine withdrawal-induced activation of locus coeruleus neurons and behavioral signs of morphine withdrawal.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Electrophysiology; In Vitro Techniques; Isoquinolines; Locus Coeruleus; Male; Morphine; Naltrexone; Narcotics; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Substance Withdrawal Syndrome; Tetrazoles | 1996 |
Use of a mu-antisense oligodeoxynucleotide as a mu opioid receptor noncompetitive antagonist in vivo.
Topics: Animals; Base Sequence; Cerebral Ventricles; Injections, Intraventricular; Injections, Subcutaneous; Male; Molecular Sequence Data; Morphine; Naltrexone; Narcotic Antagonists; Oligonucleotides, Antisense; Pain; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid, mu | 1996 |
Further evidence for a peripheral component in the enhanced antinociceptive effect of systemic morphine in mononeuropathic rats: involvement of kappa-, but not delta-opioid receptors.
Topics: Analgesia; Animals; Constriction; Drug Interactions; Injections, Intravenous; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Sciatic Nerve; Vocalization, Animal | 1996 |
Cancer pain remedy wins orphan drug status.
Topics: Blood-Brain Barrier; Constipation; Drug Therapy, Combination; Humans; Morphine; Naltrexone; Narcotic Antagonists; Nausea; Neoplasms; Orphan Drug Production; Pain; Quaternary Ammonium Compounds; United States; United States Food and Drug Administration | 1996 |
Acute pulmonary edema in a young male after intravenous nalmefene.
Topics: Acute Disease; Adult; Analgesics, Opioid; Anesthesia; Humans; Infusions, Intravenous; Male; Morphine; Naltrexone; Narcotic Antagonists; Pulmonary Edema | 1997 |
Opiate effects on 5-fluorouracil disposition in mice.
Topics: Analgesics, Opioid; Animals; Antimetabolites, Antineoplastic; Drug Interactions; Female; Fluorouracil; Liver; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone | 1997 |
Monoamine metabolism in the locus coeruleus measured concurrently with behavior during opiate withdrawal: an in vivo microdialysis study in freely moving rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Analgesics, Opioid; Animals; Behavior, Animal; Biogenic Monoamines; Hydroxyindoleacetic Acid; Locus Coeruleus; Male; Microdialysis; Monoamine Oxidase Inhibitors; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Pargyline; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 1997 |
Potentiation of delta 9-tetrahydrocannabinol-induced analgesia by morphine in mice: involvement of mu- and kappa-opioid receptors.
Topics: Analgesia; Analgesics, Opioid; Animals; Binding Sites; Dronabinol; Drug Synergism; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Pain Measurement; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1996 |
Opioid stimulation in the ventral tegmental area facilitates the onset of maternal behavior in rats.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Female; Maternal Behavior; Morphine; Naltrexone; Narcotic Antagonists; Rats; Reaction Time; Stimulation, Chemical; Ventral Tegmental Area | 1996 |
Reversal by kappa-agonists of peritoneal irritation-induced ileus and visceral pain in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetic Acid; Analgesics; Animals; Benzofurans; Benzomorphans; Cyclazocine; Fentanyl; Gastric Emptying; Intestinal Pseudo-Obstruction; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Peritoneum; Pyrroles; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Thiophenes | 1997 |
Blockade of morphine supersensitivity by an antisense oligodeoxynucleotide targeting the delta opioid receptor (DOR-1).
Topics: Analgesics; Animals; Base Sequence; Drug Tolerance; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Oligonucleotides, Antisense; Receptors, Opioid, delta | 1997 |
Influence of chronic prenatal and postnatal administration of naltrexone in locomotor activity induced by morphine in mice.
Topics: Amphetamine; Animals; Animals, Newborn; Animals, Suckling; Dose-Response Relationship, Drug; Drug Resistance; Female; Fetus; Hyperkinesis; Locomotion; Male; Maternal-Fetal Exchange; Mice; Mice, Inbred C57BL; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Pregnancy; Prenatal Exposure Delayed Effects; Receptors, Opioid | 1997 |
Nalbuphine coadministered with morphine prevents tolerance and dependence.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Therapy, Combination; Drug Tolerance; Male; Morphine; Nalbuphine; Naloxone; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Pyrrolidines; Rats; Rats, Sprague-Dawley | 1997 |
Intracranial self-stimulation in rats: sensitization to an opioid antagonist following acute or chronic treatment with mu opioid agonists.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Electric Stimulation; Male; Morphine; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Self Stimulation | 1997 |
Chronic morphine and naltrexone fail to modify mu-opioid receptor mRNA levels in the rat brain.
Topics: Animals; Brain; Corpus Striatum; DNA Primers; Drug Administration Schedule; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Morphine; Naltrexone; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; RNA, Messenger; Substance Withdrawal Syndrome | 1997 |
Inhibition of swine microglial cell phagocytosis of Cryptococcus neoformans by femtomolar concentrations of morphine.
Topics: Animals; Cryptococcus neoformans; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; GTP-Binding Proteins; Microglia; Morphine; Naltrexone; Narcotics; Phagocytosis; Swine | 1997 |
Increased release of excitatory amino acids in rat locus coeruleus in kappa-opioid agonist dependent rats precipitated by nor-binaltorphimine.
Topics: Animals; Benzeneacetamides; Butorphanol; Drug Evaluation, Preclinical; Excitatory Amino Acids; Locus Coeruleus; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Substance Withdrawal Syndrome; Substance-Related Disorders | 1997 |
Evidence for roles of kappa-opioid and NMDA receptors in the mechanism of action of ibogaine.
Topics: Animals; Corpus Striatum; Dopamine; Female; Ibogaine; Morphine; Motor Activity; N-Methylaspartate; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa; Self Administration; Substance-Related Disorders | 1997 |
Distinct components of morphine effects on cardiac myocytes are mediated by the kappa and delta opioid receptors.
Topics: Analgesics, Opioid; Animals; Animals, Newborn; Calcium; Cells, Cultured; Heart; Heart Ventricles; Morphine; Myocardial Contraction; Myocardium; Naltrexone; Narcotic Antagonists; Rats; Receptors, Opioid, delta; Receptors, Opioid, kappa | 1997 |
Neuropeptide FF in the rat spinal cord during carrageenan inflammation.
Topics: Animals; Carrageenan; Hot Temperature; Inflammation; Male; Morphine; Naltrexone; Narcotic Antagonists; Neurons; Neuropeptides; Oligopeptides; Pain; Rats; Rats, Sprague-Dawley; Spinal Cord | 1997 |
Antagonism of the response rate-decreasing effects of meperidine and morphine by beta-funaltrexamine and naltrexone in squirrel monkeys.
Topics: Animals; Conditioning, Operant; Dose-Response Relationship, Drug; Feeding Behavior; Longitudinal Studies; Male; Meperidine; Morphine; Naltrexone; Narcotic Antagonists; Reinforcement, Psychology; Saimiri | 1997 |
Differential effects of naltrindole on morphine-induced tolerance and physical dependence in rats.
Topics: Animals; Drug Tolerance; Female; Male; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Substance-Related Disorders | 1997 |
Interactions between alcohol- and opioid-induced suppression of rat testicular steroidogenesis in vivo.
Topics: Alcoholism; Animals; Dose-Response Relationship, Drug; Ethanol; Luteinizing Hormone; Male; Morphine; Naltrexone; Narcotic Antagonists; Opioid Peptides; Rats; Testis; Testosterone | 1997 |
Ultra-low doses of naltrexone or etorphine increase morphine's antinociceptive potency and attenuate tolerance/dependence in mice.
Topics: Administration, Oral; Analgesics, Opioid; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Tolerance; Etorphine; Infusions, Parenteral; Male; Mice; Mice, Inbred Strains; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Narcotics; Nociceptors; Substance Withdrawal Syndrome; Substance-Related Disorders | 1997 |
Morphine induces sepsis in mice.
Topics: Analgesics, Opioid; Animals; Female; Lipopolysaccharides; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Morphine; Naltrexone; Sepsis | 1997 |
Antinociceptive and immunosuppressive effects of opiate drugs: a structure-related activity study.
Topics: Animals; Cell Division; Codeine; Hydromorphone; Immune System; Immunosuppression Therapy; Interleukin-2; Male; Mice; Morphine; Nalorphine; Naloxone; Naltrexone; Narcotics; Oxycodone; Structure-Activity Relationship | 1997 |
Ventilation in morphine-maintained rhesus monkeys. I: Effects of naltrexone and abstinence-associated withdrawal.
Topics: Animals; Dose-Response Relationship, Drug; Female; Macaca mulatta; Male; Morphine; Naltrexone; Narcotics; Respiration; Substance Withdrawal Syndrome | 1997 |
In vivo binding of [125I]NH2-carfentanil to mu opioid receptors in mouse brain.
Topics: Animals; Autoradiography; Brain; Fentanyl; Injections, Intraperitoneal; Iodine Radioisotopes; Logistic Models; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Radioligand Assay; Receptors, Opioid, mu | 1994 |
Time course of the changes in central nitric oxide synthase activity following chronic treatment with morphine in the mouse: reversal by naltrexone.
Topics: Animals; Brain; Kinetics; Male; Mice; Morphine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Nitric Oxide Synthase; Spinal Cord | 1997 |
3-Methoxynaltrexone, a selective heroin/morphine-6beta-glucuronide antagonist.
Topics: Analgesia; Animals; Binding Sites; Binding, Competitive; CHO Cells; Cricetinae; Heroin; Male; Mice; Morphine; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu; Transfection; Tritium | 1997 |
Antagonism of morphine-like discriminative effects by beta-funaltrexamine.
Topics: Analgesics, Opioid; Animals; Buprenorphine; Cisterna Magna; Discrimination Learning; Fentanyl; Injections; Male; Meperidine; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 1997 |
Precipitated morphine withdrawal induces a conditioned aversion in the preweaning rat.
Topics: Animals; Animals, Newborn; Avoidance Learning; Conditioning, Psychological; Female; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Smell; Substance Withdrawal Syndrome | 1997 |
Discriminative stimulus effects of l-alpha-acetylmethadol (LAAM), buprenorphine and methadone in morphine-treated rhesus monkeys.
Topics: Animals; Buprenorphine; Discrimination, Psychological; Dose-Response Relationship, Drug; Female; Macaca mulatta; Male; Methadone; Methadyl Acetate; Morphine; Naltrexone; Narcotic Antagonists; Narcotics | 1997 |
Effects of opioids on the absorption of alcohol.
Topics: Analgesics, Opioid; Animals; Central Nervous System Depressants; Dose-Response Relationship, Drug; Ethanol; Gastrointestinal Agents; Injections, Intraperitoneal; Injections, Subcutaneous; Intestinal Absorption; Loperamide; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Wistar | 1997 |
The analgesia-enhancing component of ingested amniotic fluid does not affect nicotine-induced antinociception in naltrexone-treated rats.
Topics: Amniotic Fluid; Analgesia; Analgesics; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Female; Morphine; Naltrexone; Narcotic Antagonists; Nicotine; Nicotinic Agonists; Pain Measurement; Pregnancy; Rats; Reaction Time | 1997 |
Involvement of opioid mu 1 receptors in morphine-induced conditioned place preference in rats.
Topics: Analgesics, Opioid; Animals; Body Temperature; Catalepsy; Conditioning, Operant; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Rats; Rats, Wistar; Receptors, Opioid, mu | 1997 |
Supraspinal administration of opioids with selectivity for mu-, delta- and kappa-opioid receptors produces analgesia in amphibians.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Benzofurans; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Female; Fentanyl; Injections, Intraventricular; Male; Morphine; Naltrexone; Narcotics; Pyrrolidines; Rana pipiens; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1997 |
Ischemic preconditioning and morphine-induced cardioprotection involve the delta (delta)-opioid receptor in the intact rat heart.
Topics: Animals; Cardiovascular Agents; Heart; Ischemic Preconditioning, Myocardial; Male; Morphine; Myocardial Infarction; Myocardium; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid, delta; Thiopental | 1997 |
A possible new treatment approach to obsessive-compulsive disorder.
Topics: Adult; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Middle Aged; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Obsessive-Compulsive Disorder | 1997 |
Effects of naltrexone and cross-tolerance to morphine in a learned helplessness paradigm.
Topics: Analgesia; Analgesics, Opioid; Animals; Drug Tolerance; Female; Helplessness, Learned; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar | 1997 |
Butorphanol-mediated antinociception in mice: partial agonist effects and mu receptor involvement.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Butorphanol; Male; Mice; Morphine; Naltrexone; Pyrrolidines; Receptors, Opioid, mu | 1997 |
Antinociceptive effects of morphine and U-50,488H on vaginal distension in the anesthetized rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia; Animals; Blood Pressure; Cardiovascular System; Estrus; Female; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vaginal Diseases | 1997 |
Spinal mu, delta and kappa opioids alter chemical, mechanical and thermal sensitivities in amphibians.
Topics: Analgesics, Opioid; Animals; Drug Interactions; Enkephalin, Leucine-2-Alanine; Fentanyl; Injections, Spinal; Morphine; Naltrexone; Narcotic Antagonists; Nociceptors; Pain Measurement; Pain Threshold; Rana pipiens; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sensitivity and Specificity; Spinal Cord | 1997 |
Characterization of opiate binding sites on the goldfish (Carassius auratus L.) pronephric leukocytes.
Topics: Animals; Binding Sites; Goldfish; Leukocytes; Morphinans; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Receptors, Opioid, mu | 1997 |
Opioid receptor blockade throughout prenatal life confers long-term insensitivity to morphine and alters mu opioid receptors.
Topics: Analgesics, Opioid; Animals; Body Weight; Female; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 1998 |
Nalmefene and the urine opiate screen.
Topics: Adult; Cross Reactions; Drug Evaluation, Preclinical; False Positive Reactions; Humans; Immunoassay; Molecular Structure; Morphine; Naltrexone; Narcotics | 1998 |
Differential involvement of opioid receptors in intrathecal butorphanol-induced analgesia: compared to morphine.
Topics: Analgesics, Opioid; Animals; Butorphanol; Dose-Response Relationship, Drug; Injections, Spinal; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid | 1998 |
Establishing morphine and U-50,488H as discriminative stimuli in a three-choice assay with pigeons.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Columbidae; Dextroamphetamine; Discrimination Learning; Discrimination, Psychological; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Ethylketocyclazocine; Generalization, Response; Morphine; Naltrexone; Narcotic Antagonists; Narcotics | 1998 |
Morphine-6-glucuronide-induced locomotor stimulation in mice: role of opioid receptors.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred C57BL; Morphine; Morphine Derivatives; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid | 1998 |
[125I-Tyr1]biphalin binding to opioid receptors of rat brain and NG108-15 cell membranes.
Topics: Animals; Brain; Cell Line; Cell Membrane; Enkephalins; Iodine Radioisotopes; Morphine; Naltrexone; Narcotic Antagonists; Oligopeptides; Radioligand Assay; Rats; Receptors, Opioid | 1998 |
Differential modulation of mu- and delta-opioid antinociception by neuropeptide FF receptors in young mice.
Topics: Age Factors; Analgesics, Opioid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Mice; Mice, Inbred Strains; Morphine; Naltrexone; Narcotic Antagonists; Neuropeptides; Nociceptors; Oligopeptides; Receptors, Neuropeptide; Receptors, Opioid, delta; Receptors, Opioid, mu | 1997 |
Influence of oral buprenorphine, oral naltrexone or morphine on the effects of laparotomy in the rat.
Topics: Administration, Oral; Analgesics, Opioid; Animals; Behavior, Animal; Body Weight; Buprenorphine; Drinking; Eating; Laparotomy; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain, Postoperative; Rats; Rats, Wistar; Specific Pathogen-Free Organisms | 1998 |
Activation of coeruleospinal noradrenergic inhibitory controls during withdrawal from morphine in the rat.
Topics: Animals; Antibodies, Monoclonal; Efferent Pathways; Immunotoxins; Locus Coeruleus; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Neural Inhibition; Norepinephrine; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Ribosome Inactivating Proteins, Type 1; Saporins; Spinal Cord; Substance Withdrawal Syndrome | 1998 |
Role of central opioid receptor subtypes in morphine-induced alterations in peripheral lymphocyte activity.
Topics: Analgesics, Opioid; Animals; Brain; Cell Division; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intraventricular; Lymphocytes; Male; Morphine; Naltrexone; Narcotic Antagonists; Nociceptors; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1998 |
Supraspinal flumazenil inhibits the antianalgesic action of spinal dynorphin A (1-17).
Topics: Analgesia; Analgesics; Animals; Clonidine; Dose-Response Relationship, Drug; Drug Interactions; Dynorphins; Flumazenil; GABA Agonists; GABA-A Receptor Agonists; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Naltrexone; Physostigmine | 1998 |
Antinociceptive effects of the novel neuronal nicotinic acetylcholine receptor agonist, ABT-594, in mice.
Topics: Analgesics, Non-Narcotic; Animals; Azetidines; Hexamethonium; Lethal Dose 50; Male; Maze Learning; Mecamylamine; Mice; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Neurons; Nicotinic Agonists; Nicotinic Antagonists; Pain; Pyridines | 1998 |
Studies on benzodiazepines and opioids administered alone and in combination in rhesus monkeys: ventilation and drug discrimination.
Topics: Animals; Benzodiazepines; Discrimination Learning; Dose-Response Relationship, Drug; Drug Synergism; Female; Flumazenil; Macaca mulatta; Male; Midazolam; Morphine; Naltrexone; Narcotics; Respiration | 1998 |
The rate-decreasing effects of fentanyl derivatives in pigeons before, during and after chronic morphine treatment.
Topics: Analgesics; Animals; Columbidae; Conditioning, Psychological; Dose-Response Relationship, Drug; Drug Tolerance; Fentanyl; Morphine; Naltrexone | 1998 |
Interactions between N-methyl-D-aspartate receptor antagonists and the discriminative stimulus effects of morphine in rats.
Topics: Animals; Binding, Competitive; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Generalization, Stimulus; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate | 1998 |
Alteration in regulation of serotonin release in rat dorsal raphe nucleus after prolonged exposure to morphine.
Topics: Animals; Drug Tolerance; Male; Morphine; Naltrexone; Narcotics; Opioid-Related Disorders; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Serotonin | 1998 |
The expression of interleukin-1-beta converting enzyme (ICE) in rat is decreased following chronic exposure to morphine.
Topics: Animals; Brain; Caspase 1; Cysteine Endopeptidases; Drug Interactions; Interleukin-1; Male; Morphine; Naltrexone; Narcotic Antagonists; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; Spleen | 1998 |
NTI4F: a non-peptide fluorescent probe selective for functional delta opioid receptors.
Topics: Animals; Bridged-Ring Compounds; Cell Line; Dogs; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Fluorescent Dyes; Imides; Microscopy, Confocal; Microscopy, Fluorescence; Morphine; Naltrexone; Receptors, Opioid, delta; Transfection | 1998 |
Beta-funaltrexamine discriminates between two subtypes of mu2-opioid receptors in electrically stimulated longitudinal muscle of guinea pig ileum.
Topics: Acetylcholine; Animals; Binding, Competitive; Electric Stimulation; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists; Nerve Endings; Receptors, Opioid, mu; Tetrodotoxin | 1998 |
Involvement of mu- and delta-opioid receptors in the ethanol-associated place preference in rats exposed to foot shock stress.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Ethanol; Exploratory Behavior; Foot; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Morphine; Naloxone; Naltrexone; Narcotics; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu | 1998 |
Prevention of apomorphine- or cisplatin-induced emesis in the dog by a combination of methylnaltrexone and morphine.
Topics: Administration, Oral; Animals; Antiemetics; Antineoplastic Agents; Apomorphine; Cisplatin; Dogs; Drug Interactions; Drug Therapy, Combination; Emetics; Male; Morphine; Naltrexone; Narcotics; Quaternary Ammonium Compounds; Vomiting | 1998 |
Apparent thermodynamic parameters of ligand binding to the cloned rat mu-opioid receptor.
Topics: Analgesics; Animals; Binding, Competitive; CHO Cells; Cricetinae; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Fentanyl; Ligands; Methadone; Morphine; Naltrexone; Narcotic Antagonists; Pentazocine; Peptide Fragments; Peptides; Radioligand Assay; Rats; Receptors, Opioid, mu; Somatostatin; Sufentanil; Thermodynamics; Time Factors | 1998 |
MU-opioid receptor-knockout mice: role of mu-opioid receptor in morphine mediated immune functions.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Binding, Competitive; Disease Models, Animal; Drug Implants; Exons; Gene Targeting; Immune System; Immunosuppression Therapy; Interleukin-2; Ligands; Macrophage Activation; Macrophages, Peritoneal; Mice; Mice, Knockout; Mitogens; Morphine; Naltrexone; Organ Size; Phagocytosis; Receptors, Opioid, mu; Spleen; Substance-Related Disorders; Thymidine; Thymus Gland; Tumor Necrosis Factor-alpha | 1998 |
The mu opioid irreversible antagonist beta-funaltrexamine differentiates the discriminative stimulus effects of opioids with high and low efficacy at the mu opioid receptor.
Topics: Animals; Buprenorphine; Butorphanol; Columbidae; Discrimination Learning; Female; Fentanyl; Levallorphan; Methadone; Morphine; Nalbuphine; Nalorphine; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu | 1998 |
Comparison of the discriminative and antinociceptive effects of morphine and its glucuronide metabolites after central or systemic administration in the rat.
Topics: Analgesics, Opioid; Animals; Discrimination Learning; Dose-Response Relationship, Drug; Injections, Intraventricular; Injections, Subcutaneous; Male; Morphine; Morphine Derivatives; Naltrexone; Rats; Rats, Sprague-Dawley | 1998 |
Validation study of the conductometrical analysis. Application to the drug release studies from controlled release systems.
Topics: Conductometry; Delayed-Action Preparations; Morphine; Naltrexone; Reproducibility of Results | 1998 |
Peripheral effects of opioids in a model of chronic intestinal inflammation in mice.
Topics: Animals; Antidiarrheals; Body Weight; Carbon Monoxide; Enteritis; Gastrointestinal Transit; Jejunum; Loperamide; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Receptors, Opioid | 1998 |
Opioid antagonist modulation of ischaemia-induced ventricular arrhythmias: a peripheral mechanism.
Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Cardiovascular System; Coronary Disease; Drug Interactions; Heart Rate; Morphine; Myocardial Reperfusion Injury; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Rabbits | 1999 |
The effects of morphine, nicotine and epibatidine on lymphocyte activity and hypothalamic-pituitary-adrenal axis responses.
Topics: Adjuvants, Immunologic; Analgesics, Opioid; Animals; Bridged Bicyclo Compounds, Heterocyclic; Chlorisondamine; Dose-Response Relationship, Drug; Drug Interactions; Hypothalamo-Hypophyseal System; Lymphocyte Activation; Male; Morphine; Naltrexone; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pituitary-Adrenal System; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Receptors, Opioid; T-Lymphocytes | 1999 |
Heroin antinociception changed from mu to delta receptor in streptozotocin-treated mice.
Topics: Analgesics, Opioid; Animals; Anti-Bacterial Agents; Benzylidene Compounds; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Heroin; Injections, Intraventricular; Male; Mice; Morphine; Morphine Derivatives; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Pain; Receptors, Opioid, delta; Receptors, Opioid, mu; Streptozocin; Time Factors | 1998 |
Effects of test conditions on the outcome of place conditioning with morphine and naltrexone in mice.
Topics: Animals; Conditioning, Psychological; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists | 1999 |
Chronic naltrindole administration does not modify the inhibitory effect of morphine on vocalization responses in the tail electric stimulation test in rats.
Topics: Albinism; Animals; Electric Stimulation; Male; Morphine; Movement; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Tail; Vocalization, Animal | 1999 |
Role of the kappa-opioid system in the attenuation of the morphine-induced place preference under chronic pain.
Topics: Animals; Chronic Disease; Conditioning, Psychological; Formaldehyde; Hindlimb; Inflammation; Male; Morphine; Naltrexone; Pain; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Reward; Time Factors | 1999 |
Discriminative stimulus effects of naltrexone after a single dose of morphine in the rat.
Topics: Animals; Discrimination Learning; Dose-Response Relationship, Drug; Drug Interactions; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Sprague-Dawley; Time Factors | 1999 |
Effect of gonadectomy on discriminative stimulus effects of morphine in female versus male rats.
Topics: Animals; Buprenorphine; Castration; Discrimination Learning; Female; Fentanyl; Gonadal Steroid Hormones; Injections; Male; Morphine; Nalbuphine; Naltrexone; Narcotic Antagonists; Narcotics; Nociceptors; Rats; Rats, Sprague-Dawley; Sex Characteristics | 1999 |
Effects of opioid receptor antagonists on the effects of i.v. morphine on carrageenin evoked c-Fos expression in the superficial dorsal horn of the rat spinal cord.
Topics: Analgesics, Opioid; Animals; Carrageenan; Hindlimb; Inflammation; Injections, Intravenous; Male; Morphine; Naltrexone; Narcotic Antagonists; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin; Spinal Cord | 1999 |
Different roles of mu-, delta- and kappa-opioid receptors in ethanol-associated place preference in rats exposed to conditioned fear stress.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Behavior, Animal; Central Nervous System Depressants; Conditioning, Psychological; Ethanol; Fear; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stress, Psychological | 1999 |
A morphine-triggered delivery system useful in the treatment of heroin addiction.
Topics: Biodegradation, Environmental; Drug Delivery Systems; Heroin Dependence; Humans; Lipase; Materials Testing; Membranes, Artificial; Microspheres; Molecular Structure; Morphine; Naltrexone; Polymers; Porosity | 1993 |
[A molecular mechanism for supersensitization of adenylyl cyclase system in cloned opioid receptor-transfected cells following sustained opioid treatment].
Topics: Adenylyl Cyclases; Analgesics; Animals; Atropine; Benzeneacetamides; Carbachol; CHO Cells; Clone Cells; Cricetinae; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP Phosphohydrolases; Morphine; Muscarinic Agonists; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Transfection | 1998 |
The importance of the number of NMDA receptors in the development of supersensitivity or tolerance to and dependence on morphine.
Topics: Analgesics, Opioid; Animals; Brain; Dizocilpine Maleate; Drug Tolerance; Excitatory Amino Acid Antagonists; Kinetics; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain Measurement; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Substance-Related Disorders | 1999 |
The selective mGlu2/3 receptor agonist LY354740 attenuates morphine-withdrawal-induced activation of locus coeruleus neurons and behavioral signs of morphine withdrawal.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Bridged Bicyclo Compounds; Electrophysiology; Excitatory Amino Acid Agonists; Locus Coeruleus; Male; Membrane Potentials; Morphine; Morphine Dependence; Naltrexone; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Substance Withdrawal Syndrome | 1999 |
Gastric effects of methylnaltrexone on mu, kappa, and delta opioid agonists induced brainstem unitary responses.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Animals, Newborn; Brain Stem; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Morphine; Naltrexone; Narcotic Antagonists; Neurons; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Solitary Nucleus; Stomach; Vagus Nerve | 1999 |
Evaluation of hypothermia-induced analgesia and influence of opioid antagonists in leopard frogs (Rana pipiens).
Topics: Analgesia; Analgesics, Opioid; Animals; Evaluation Studies as Topic; Hypothermia, Induced; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rana pipiens | 1999 |
Isolation reduces contextual but not auditory-cue fear conditioning: a role for endogenous opioids.
Topics: Analysis of Variance; Animals; Avoidance Learning; Conditioning, Classical; Cues; Fear; Female; Male; Morphine; Naltrexone; Narcotic Antagonists; Opioid Peptides; Rats; Rats, Long-Evans; Social Isolation | 1999 |
Direct preconditioning of cardiac myocytes via opioid receptors and KATP channels.
Topics: Adenosine Triphosphate; Analgesics, Opioid; Animals; Anti-Arrhythmia Agents; Benzylidene Compounds; Cells, Cultured; Chick Embryo; Decanoic Acids; Hydroxy Acids; Ischemic Preconditioning, Myocardial; Morphine; Muscle Fibers, Skeletal; Myocardium; Naloxone; Naltrexone; Narcotic Antagonists; Potassium Channels; Receptors, Opioid | 1999 |
The discriminative stimulus effects of naloxone and naltrexone in morphine-treated rhesus monkeys: comparison of oral and subcutaneous administration.
Topics: Animals; Discrimination Learning; Female; Macaca mulatta; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics | 1999 |
Supersensitization of the adenylyl cyclase system in Chinese hamster ovary cells co-expressing cloned opioid receptors and Gz, a PTX-insensitive G protein.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Benzeneacetamides; CHO Cells; Cricetinae; Cyclic AMP; Enzyme Activation; Female; GTP-Binding Protein alpha Subunits; Heterotrimeric GTP-Binding Proteins; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pertussis Toxin; Pyrrolidines; Receptors, Opioid; Virulence Factors, Bordetella | 1999 |
Ligands for opioid and sigma-receptors improve cardiac electrical stability in rat models of post-infarction cardiosclerosis and stress.
Topics: Animals; Anti-Arrhythmia Agents; beta-Endorphin; Disease Models, Animal; Dynorphins; Enkephalin, Leucine-2-Alanine; Heart; Immobilization; Ligands; Morphine; Myocardial Infarction; Myocardium; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Piperidines; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, delta; Stress, Physiological; Ventricular Fibrillation | 1999 |
ASP147 in the third transmembrane helix of the rat mu opioid receptor forms ion-pairing with morphine and naltrexone.
Topics: Animals; Aspartic Acid; Carboxylic Acids; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Ligands; Morphine; Mutagenesis, Site-Directed; Naltrexone; Protein Binding; Rats; Receptors, Opioid, mu | 1999 |
Infusion of beta-FNA into the thalamus attenuates morphine-induced c-Fos induction in the rat caudate putamen.
Topics: Analgesics, Opioid; Animals; Caudate Nucleus; Infusions, Parenteral; Male; Morphine; Naltrexone; Narcotic Antagonists; Nerve Tissue Proteins; Proto-Oncogene Proteins c-fos; Putamen; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Thalamic Nuclei | 1999 |
Discriminative stimulus effects of morphine in squirrel monkeys: stimulants, opioids, and stimulant-opioid combinations.
Topics: Amphetamine; Analgesics, Opioid; Anesthetics, Local; Animals; Anti-Anxiety Agents; Cocaine; Discrimination Learning; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Combinations; Fentanyl; Male; Morphine; Naltrexone; Narcotic Antagonists; Piperazines; Receptors, Opioid; Saimiri; Selective Serotonin Reuptake Inhibitors | 1999 |
Spinal effect of a neuropeptide FF analogue on hyperalgesia and morphine-induced analgesia in mononeuropathic and diabetic rats.
Topics: Analgesia; Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Diabetes Mellitus, Experimental; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Hyperalgesia; Injections, Spinal; Male; Morphine; Naltrexone; Narcotic Antagonists; Nervous System Diseases; Oligopeptides; Pain; Rats; Rats, Sprague-Dawley; Somatostatin; Time Factors; Vocalization, Animal | 1999 |
Delta(2)-opioid receptor mediation of morphine-induced CCK release in the frontal cortex of the freely moving rat.
Topics: Analgesics, Opioid; Animals; Cholecystokinin; Extracellular Space; Injections; Ligands; Male; Microdialysis; Morphine; Naltrexone; Narcotic Antagonists; Prefrontal Cortex; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Somatostatin | 1999 |
Synthesis, opioid receptor binding, and biological activities of naltrexone-derived pyrido- and pyrimidomorphinans.
Topics: Analgesics; Animals; Binding, Competitive; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Ileum; Male; Mice; Mice, Inbred Strains; Morphinans; Morphine; Muscle Contraction; Naltrexone; Protein Binding; Rats; Receptors, Opioid; Vas Deferens | 1999 |
Opioid-dependent effects of inescapable shock on escape behavior and conditioned fear responding are mediated by the dorsal raphe nucleus.
Topics: Analgesics, Opioid; Animals; Catheterization; Conditioning, Psychological; Electroshock; Escape Reaction; Fear; Helplessness, Learned; Male; Microinjections; Morphine; Naltrexone; Narcotic Antagonists; Opioid Peptides; Periaqueductal Gray; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Reinforcement Schedule; Serotonin | 1999 |
Discriminative stimulus effects of nalbuphine in nontreated and morphine-treated pigeons.
Topics: Analgesics, Opioid; Animals; Columbidae; Cues; Discrimination Learning; Discrimination, Psychological; Morphine; Nalbuphine; Naltrexone; Narcotic Antagonists; Reversal Learning | 1999 |
Strain-dependent effects of MK-801 on passive avoidance behaviour in mice: interactions with morphine and immobilization stress.
Topics: Animals; Avoidance Learning; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Immobilization; Memory; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Species Specificity; Stress, Psychological | 1999 |
Role of the dorsal raphe nucleus in morphine-induced immediate early gene expression in the rat striatum.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Gene Expression; Genes, fos; Genes, Immediate-Early; Immunohistochemistry; Male; Morphine; Naltrexone; Narcotic Antagonists; Neostriatum; Periaqueductal Gray; Proto-Oncogene Proteins c-jun; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Serotonin | 1999 |
Enhancement of the contact hypersensitivity reaction by acute morphine administration at the elicitation phase.
Topics: Animals; Croton Oil; Dermatitis, Contact; Dermatitis, Irritant; Dinitrofluorobenzene; Ear, External; Immunization; Injections, Subcutaneous; Interferon-gamma; Male; Morphine; Naltrexone; Rats; Rats, Inbred Lew | 1999 |
Hyperalgesic response to noxious stimulation in genetically polydipsic mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Drinking; Drinking Behavior; Hot Temperature; Hyperalgesia; Locomotion; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred Strains; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Nociceptors; Pain Measurement; Reaction Time; Water Deprivation | 1999 |
Antagonism of heroin and morphine self-administration in rats by the morphine-6beta-glucuronide antagonist 3-O-methylnaltrexone.
Topics: Animals; Conditioning, Operant; Dose-Response Relationship, Drug; Heroin; Injections, Subcutaneous; Male; Morphine; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Narcotics; Pain Measurement; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley; Rats, Wistar; Self Administration | 1999 |
A comparative study of the effects of morphine in the dorsal periaqueductal gray and nucleus accumbens of rats submitted to the elevated plus-maze test.
Topics: Analgesics, Opioid; Animals; Conditioning, Psychological; Fear; Male; Maze Learning; Microinjections; Morphine; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Periaqueductal Gray; Rats; Rats, Wistar; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1999 |
Neonatal naltrindole and handling differently affect morphine antinociception in male and female rats.
Topics: Analgesics; Animals; Female; Handling, Psychological; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Rats; Rats, Wistar; Sex Characteristics; Stress, Physiological | 1999 |
ATP-gated K(+) channel openers enhance opioid antinociception: indirect evidence for the release of endogenous opioid peptides.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenosine Triphosphate; Analgesics; Animals; Cromakalim; Diazoxide; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Glyburide; Injections, Intraventricular; Ion Channel Gating; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Narcotic Antagonists; Nociceptors; Opioid Peptides; Pain; Potassium Channels; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin | 1999 |
Role of corticotropin-releasing factor receptor-1 in opiate withdrawal.
Topics: Animals; Behavior, Animal; Male; Morphine; Naltrexone; Narcotic Antagonists; Protein Isoforms; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone; Substance Withdrawal Syndrome | 2000 |
Discriminative stimulus effects of two doses of fentanyl in rats: pharmacological selectivity and effect of training dose on agonist and antagonist effects of mu opioids.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Central Nervous System Stimulants; Conditioning, Operant; Dextroamphetamine; Dose-Response Relationship, Drug; Fentanyl; Male; Methadone; Morphine; Nalbuphine; Nalorphine; Naltrexone; Narcotic Antagonists; Narcotics; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2000 |
Changes in analgesia-producing mechanism of repeated cold stress loading in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Anti-Anxiety Agents; Anxiety; Cold Temperature; Diazepam; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Pain Threshold; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stress, Physiological | 2000 |
Mechanisms of chloroquine-induced body-scratching behavior in rats: evidence of involvement of endogenous opioid peptides.
Topics: Animals; Antimalarials; Chloroquine; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Opioid Peptides; Pruritus; Rats | 2000 |
Enhanced analgesic potency and reduced tolerance of morphine in 129/SvEv mice: evidence for a deficiency in GM1 ganglioside-regulated excitatory opioid receptor functions.
Topics: Animals; Drug Tolerance; G(M1) Ganglioside; Male; Mice; Mice, Inbred Strains; Morphine; Naltrexone; Receptors, Opioid; Time Factors | 2000 |
Modulatory effect of endogenous and exogenous opioids on the excitatory reflex pathway of the rat ileum.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Ileum; In Vitro Techniques; Male; Morphine; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Narcotics; Peristalsis; Rats; Rats, Wistar; Receptors, Opioid; Somatostatin | 2000 |
Acute delta-opioid receptor activation induces CREB phosphorylation in NG108-15 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Analgesics, Opioid; Blotting, Western; Calmodulin; Cell Line; Cyclic AMP Response Element-Binding Protein; Enkephalin, D-Penicillamine (2,5)-; Enzyme Inhibitors; Humans; Isoquinolines; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Phosphorylation; Protein Kinase C; Protein Synthesis Inhibitors; Receptors, Opioid, delta; Time Factors | 2000 |
An experimental itch model in monkeys: characterization of intrathecal morphine-induced scratching and antinociception.
Topics: Analgesics, Opioid; Animals; Antipruritics; Dose-Response Relationship, Drug; Female; Hot Temperature; Injections, Spinal; Macaca mulatta; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Pruritus; Receptors, Opioid | 2000 |
Short-acting NMDA receptor antagonist MRZ 2/576 produces prolonged suppression of morphine withdrawal in mice.
Topics: Analysis of Variance; Animals; Dose-Response Relationship, Drug; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Phthalazines; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome; Tremor | 2000 |
Activation of c-fos expression in hypothalamic nuclei by mu- and kappa-receptor agonists: correlation with catecholaminergic activity in the hypothalamic paraventricular nucleus.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Male; Methoxyhydroxyphenylglycol; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Norepinephrine; Paraventricular Hypothalamic Nucleus; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Suprachiasmatic Nucleus; Supraoptic Nucleus | 2000 |
Acute opioid but not benzodiazepine dependence in rats responding for intracranial self-stimulation.
Topics: Animals; Benzodiazepines; Brain; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Male; Morphine; Naltrexone; Opioid-Related Disorders; Rats; Rats, Sprague-Dawley; Reinforcement Schedule; Self Stimulation; Substance-Related Disorders | 2000 |
Morphine increases susceptibility to oral Salmonella typhimurium infection.
Topics: Animals; Cytokines; Disease Susceptibility; Female; Germ-Free Life; Mice; Mice, Inbred C3H; Morphine; Mouth; Mouth Diseases; Naltrexone; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peyer's Patches; RNA, Messenger; Salmonella Infections, Animal; Salmonella typhimurium | 2000 |
Inhibitory effect of intracerebroventricularly-administered [D-Arg(2), beta-Ala(4)]-dermorphin (1-4) on gastrointestinal transit.
Topics: Analgesics; Animals; Charcoal; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Female; Gastrointestinal Transit; Injections, Intraventricular; Mice; Mice, Inbred Strains; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides | 2000 |
Daily mirfentanil induces (cross-) tolerance to the rate-decreasing effects of morphine and not mirfentanil.
Topics: Analgesics; Animals; Arousal; Columbidae; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Tolerance; Fentanyl; Ketamine; Morphine; Naltrexone | 1999 |
Naltrexone and morphine alter the discrimination and plasma levels of ethanol.
Topics: Animals; Central Nervous System Depressants; Discrimination, Psychological; Dose-Response Relationship, Drug; Ethanol; Hypnotics and Sedatives; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Pentobarbital; Rats; Rats, Inbred Lew | 1999 |
Acute exposure to saccharin reduces morphine analgesia in the the rat: evidence for involvement of N-methyl-D-aspartate and peripheral opioid receptors.
Topics: Analgesia; Analgesics, Opioid; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Quaternary Ammonium Compounds; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Saccharin; Sweetening Agents | 2000 |
Effects of differential modulation of mu-, delta- and kappa-opioid systems on bicuculline-induced convulsions in the mouse.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Bicuculline; Brain Chemistry; Convulsants; Enkephalin, D-Penicillamine (2,5)-; Epilepsy, Tonic-Clonic; Injections, Intraventricular; Injections, Subcutaneous; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Quinolines; Receptors, GABA-A; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Seizures; Synaptic Transmission | 2000 |
Morphine tolerance in mice changes response of heroin from mu to delta opioid receptors.
Topics: Analgesics, Opioid; Animals; Drug Tolerance; Heroin; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Narcotics; Quaternary Ammonium Compounds; Receptors, Opioid, delta; Receptors, Opioid, mu | 2000 |
Naloxone antagonizes GABA(A)/benzodiazepine receptor function in rat corticohippocampal synaptoneurosomes.
Topics: Amobarbital; Animals; Cerebral Cortex; Chlorine; GABA Modulators; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hippocampus; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Neurons; Radioisotopes; Rats; Rats, Sprague-Dawley; Synaptosomes | 2000 |
Role of agonist-dependent receptor internalization in the regulation of mu opioid receptors.
Topics: Acetylcholine; Animals; Electric Stimulation; Endocytosis; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enteric Nervous System; Guinea Pigs; Ileum; Morphine; Naltrexone; Narcotic Antagonists; Neurons; Opioid Peptides; Organ Culture Techniques; Receptors, Opioid, mu | 2000 |
Acute dependence on, but not tolerance to, heroin and morphine as measured by respiratory effects in rhesus monkeys.
Topics: Analgesics, Opioid; Animals; Carbon Dioxide; Dose-Response Relationship, Drug; Drug Tolerance; Heroin; Heroin Dependence; Macaca mulatta; Morphine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Respiration; Time Factors | 2000 |
The effect of nimodipine on opioid antagonist-induced upregulation and supersensitivity.
Topics: Animals; Calcium Channel Blockers; Dose-Response Relationship, Drug; Drug Tolerance; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Nimodipine; Receptors, Opioid, mu; Up-Regulation | 2000 |
Opiate withdrawal in the fetal rat: a behavioral profile.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Female; Fetus; Humans; Maternal-Fetal Exchange; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Pregnancy; Rats; Substance Withdrawal Syndrome | 2000 |
Upregulation of galanin binding sites and GalR1 mRNA levels in the mouse locus coeruleus following chronic morphine treatments and precipitated morphine withdrawal.
Topics: Animals; Autoradiography; Behavior, Animal; Drug Administration Schedule; Female; Galanin; In Situ Hybridization; Iodine Radioisotopes; Locus Coeruleus; Mice; Mice, Inbred C57BL; Morphine; Naltrexone; Nucleus Accumbens; Receptors, Galanin; Receptors, Neuropeptide; RNA, Messenger; Substance Withdrawal Syndrome; Up-Regulation; Ventral Tegmental Area | 2000 |
Further characterization of the discriminative stimulus effects of spiradoline.
Topics: Analgesics, Non-Narcotic; Animals; Benzeneacetamides; Discrimination Learning; Drug Interactions; Male; Morphine; Naltrexone; Narcotic Antagonists; Nicotinic Antagonists; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Tetrahydronaphthalenes | 2000 |
Calmodulin regulation of basal and agonist-stimulated G protein coupling by the mu-opioid receptor (OP(3)) in morphine-pretreated cell.
Topics: Amino Acid Substitution; Animals; Calmodulin; Cell Line; Cell Membrane; Chickens; Egtazic Acid; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Kidney; Kinetics; Morphine; Mutagenesis, Site-Directed; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu; Recombinant Proteins; Transfection | 2000 |
Behavioral activation induced by D(2)-like receptor stimulation during opiate withdrawal.
Topics: Analgesics, Opioid; Animals; Apomorphine; Behavior, Animal; Dopamine Agonists; Dopamine Antagonists; Drug Synergism; Locomotion; Male; Morphine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Stereotyped Behavior; Substance Withdrawal Syndrome | 2000 |
[Regulation of the central opioidergic nervous system on the emotional state of anxiety and its possible mechanisms].
Topics: Animals; Anxiety; Brain; Morphine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Rats; Serotonin; Substance Withdrawal Syndrome | 1997 |
Morphine stimulates mesangial cell TNF-alpha and nitrite production.
Topics: Animals; Antibodies, Monoclonal; Cell Line, Transformed; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Gene Expression Regulation; Glomerular Mesangium; Glomerulosclerosis, Focal Segmental; Heroin Dependence; HIV Envelope Protein gp120; HIV Infections; Lipopolysaccharides; Macrophages; Mice; Morphine; Muscle, Smooth, Vascular; Naloxone; Naltrexone; Narcotic Antagonists; NG-Nitroarginine Methyl Ester; Nitrites; Tumor Necrosis Factor-alpha | 2000 |
Naltrexone-precipitated morphine withdrawal in infant rat is attenuated by acute administration of NOS inhibitors but not NMDA receptor antagonists.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Animals, Newborn; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Humans; Indazoles; Infant, Newborn; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Neonatal Abstinence Syndrome; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Rats; Rats, Long-Evans; Receptors, N-Methyl-D-Aspartate | 2000 |
beta-Funaltrexamine inactivates ORL1 receptors in BE(2)-C human neuroblastoma cells.
Topics: Brain Neoplasms; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Humans; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Neuroblastoma; Nociceptin; Nociceptin Receptor; Opioid Peptides; Receptors, Opioid; Receptors, Opioid, mu; Tumor Cells, Cultured | 2000 |
Expression of fos-related antigens in the nucleus accumbens during opiate withdrawal and their attenuation by a D2 dopamine receptor agonist.
Topics: Animals; Apomorphine; Behavior, Animal; Dopamine Agonists; Dopamine Antagonists; Immunohistochemistry; Lithium Chloride; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Nucleus Accumbens; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Substance Withdrawal Syndrome | 2000 |
Methocinnamox is a potent, long-lasting, and selective antagonist of morphine-mediated antinociception in the mouse: comparison with clocinnamox, beta-funaltrexamine, and beta-chlornaltrexamine.
Topics: Analgesics, Opioid; Animals; Binding, Competitive; Cerebral Cortex; Cinnamates; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Male; Mice; Morphine; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Pain Measurement; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2000 |
Selectivity of mu-opioid receptor determined by interfacial residues near third extracellular loop.
Topics: Amino Acid Substitution; Animals; Benzamides; Benzomorphans; Binding Sites; Binding, Competitive; COS Cells; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Fentanyl; Guanosine 5'-O-(3-Thiotriphosphate); Ligands; Morphine; Mutation; Naloxone; Naltrexone; Narcotic Antagonists; Peptides; Piperazines; Protein Conformation; Radioligand Assay; Rats; Receptors, Opioid, mu; Signal Transduction; Sulfur Radioisotopes | 2000 |
Assessment of SNC 80 and naltrindole within a conditioned taste aversion design.
Topics: Animals; Avoidance Learning; Benzamides; Conditioning, Operant; Dose-Response Relationship, Drug; Female; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Piperazines; Rats; Rats, Long-Evans; Receptors, Opioid, delta; Saccharin; Sweetening Agents; Taste | 2000 |
Morphine discriminative control is mediated by the mu opioid receptor: assessment of delta opioid substitution and antagonism.
Topics: Animals; Benzamides; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Female; Generalization, Response; Methadone; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Piperazines; Rats; Rats, Long-Evans; Receptors, Opioid, delta; Receptors, Opioid, mu | 2000 |
A pharmacological analysis of the substrates underlying conditioned feeding induced by repeated opioid stimulation of the nucleus accumbens.
Topics: Analgesics, Opioid; Animals; Conditioning, Psychological; Dopamine Antagonists; Eating; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Nucleus Accumbens; Rats; Rats, Sprague-Dawley | 2000 |
Inhibitory effects of morphine on some inflammation-related parameters in the goldfish Carassius auratus L.
Topics: Analgesics, Opioid; Animals; Chemotaxis; Coloring Agents; Evans Blue; Exudates and Transudates; Fish Diseases; Goldfish; Injections, Intraperitoneal; Leukocyte Count; Morphine; Naltrexone; Narcotic Antagonists; Peritonitis; Thioglycolates | 2000 |
Endomorphin-1 induces antinociception without immunomodulatory effects in the rat.
Topics: Analgesics, Opioid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Immune System; Injections, Intraventricular; Interferon-gamma; Lymphocyte Activation; Male; Morphine; Naltrexone; Oligopeptides; Rats; Rats, Inbred Lew | 2000 |
Morphine enhances interleukin-12 and the production of other pro-inflammatory cytokines in mouse peritoneal macrophages.
Topics: Adjuvants, Immunologic; Analgesics, Opioid; Animals; Corynebacterium; Delayed-Action Preparations; Female; Inflammation Mediators; Interferon-gamma; Interleukin-10; Interleukin-12; Lipopolysaccharides; Macrophages, Peritoneal; Mice; Mice, Inbred C3H; Morphine; Naltrexone; Narcotic Antagonists; RNA, Messenger; Stimulation, Chemical; Tumor Necrosis Factor-alpha | 2000 |
N-Cyclohexylethyl-N-noroxymorphindole: a mu-opioid preferring analogue of naltrindole.
Topics: Analgesics; Animals; Mice; Molecular Structure; Morphine; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Pain Measurement; Receptors, Opioid, mu | 2000 |
Spinal kappa-opioid system plays an important role in suppressing morphine withdrawal syndrome in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Male; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid, kappa; Substance Withdrawal Syndrome | 2000 |
Dose- and time-dependent bimodal effects of kappa-opioid agonists on locomotor activity in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetamides; Animals; Benzomorphans; Dose-Response Relationship, Drug; Isothiocyanates; Male; Mice; Morphine; Motor Activity; Naloxone; Naltrexone; Receptors, Opioid, kappa; Time Factors | 2000 |
Inhibition of morphine tolerance development by a substance P-opioid peptide chimera.
Topics: Analgesics, Opioid; Animals; Drug Tolerance; Indoles; Isoindoles; Male; Morphine; Naltrexone; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Structure-Activity Relationship; Substance P | 2000 |
Morphine-6 beta-glucuronide has a higher efficacy than morphine as a mu-opioid receptor agonist in the rat locus coeruleus.
Topics: Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Locus Coeruleus; Male; Membrane Potentials; Morphine; Morphine Derivatives; Naltrexone; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 2000 |
Morphine inhibits human microglial cell production of, and migration towards, RANTES.
Topics: Brain; Calcium; Cells, Cultured; Chemokine CCL5; Chemotaxis; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Fetus; Humans; Interleukin-1; Lipopolysaccharides; Microglia; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Recombinant Proteins | 2000 |
Testosterone is required for corticosteroid-binding globulin upregulation by morphine to be fully manifested.
Topics: Animals; Male; Morphine; Naltrexone; Orchiectomy; Rats; Rats, Sprague-Dawley; Testosterone; Transcortin; Up-Regulation | 2000 |
The role of opioid receptors in morphine withdrawal in the infant rat.
Topics: Animals; Animals, Newborn; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Long-Evans; Receptors, Opioid; Receptors, Opioid, mu; Somatostatin; Substance Withdrawal Syndrome | 2000 |
Mapping of c-fos gene expression in the brain during morphine dependence and precipitated withdrawal, and phenotypic identification of the striatal neurons involved.
Topics: Animals; Brain; Corpus Striatum; Drug Implants; Gene Expression Regulation; Genes, fos; Male; Morphine; Morphine Dependence; Naltrexone; Neurons; Organ Specificity; Phenotype; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; RNA, Messenger; Substance Withdrawal Syndrome; Transcription, Genetic | 2000 |
Acute thermal hyperalgesia elicited by low-dose morphine in normal mice is blocked by ultra-low-dose naltrexone, unmasking potent opioid analgesia.
Topics: Acute Disease; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Etorphine; Hot Temperature; Hyperalgesia; Male; Mice; Morphine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Pain Threshold; Receptors, Opioid | 2001 |
Intestinal inflammation enhances the inhibitory effects of opioids on intestinal permeability in mice.
Topics: Analgesics, Opioid; Animals; Croton Oil; Dose-Response Relationship, Drug; Enteritis; Gastrointestinal Motility; Injections, Intraventricular; Intestinal Absorption; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Permeability; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, sigma | 2001 |
Parametric evaluation of the development of sensitization to the effects of morphine on locomotor activity.
Topics: Animals; Area Under Curve; Dose-Response Relationship, Drug; Drug Tolerance; Male; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Sprague-Dawley | 2001 |
Injections of an opioid antagonist into the locus coeruleus and periaqueductal gray but not the amygdala precipitates morphine withdrawal in the 7-day-old rat.
Topics: Age Factors; Amygdala; Animals; Animals, Newborn; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Locus Coeruleus; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Neural Pathways; Opioid-Related Disorders; Periaqueductal Gray; Quaternary Ammonium Compounds; Rats; Rats, Long-Evans; Substance Withdrawal Syndrome | 2001 |
Place aversion induced by blockade of mu or activation of kappa opioid receptors in the dorsal periaqueductal gray matter.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analysis of Variance; Animals; Behavior, Animal; Conditioning, Operant; Dose-Response Relationship, Drug; Male; Morphine; Naltrexone; Periaqueductal Gray; Rats; Rats, Wistar; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin | 2000 |
Activity of mu- and delta-opioid agonists in vas deferens from mice deficient in MOR gene.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Female; Genotype; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Mutant Strains; Morphine; Muscle Contraction; Naltrexone; Narcotic Antagonists; Oligopeptides; Receptors, Opioid, delta; Receptors, Opioid, mu; Vas Deferens | 2001 |
The novel kappa-opioid receptor agonist TRK-820 suppresses the rewarding and locomotor-enhancing effects of morphine in mice.
Topics: Animals; Dose-Response Relationship, Drug; Male; Mice; Morphinans; Morphine; Motor Activity; Naltrexone; Narcotics; Receptors, Opioid, kappa; Reward; Spiro Compounds | 2001 |
Involvement of substance P and central opioid receptors in morphine modulation of the CHS response.
Topics: Androstanes; Animals; Benzimidazoles; Dermatitis, Contact; Dinitrofluorobenzene; Disease Models, Animal; Drug Administration Routes; Male; Morphine; Naltrexone; Narcotic Antagonists; Neurokinin-1 Receptor Antagonists; Quaternary Ammonium Compounds; Rats; Rats, Inbred Lew; Receptors, Opioid; Specific Pathogen-Free Organisms; Substance P | 2001 |
Inverse agonist action of Leu-enkephalin at delta(2)-opioid receptors mediates spinal antianalgesia.
Topics: Analgesics, Opioid; Animals; Benzylidene Compounds; Cholecystokinin; Drug Tolerance; Enkephalin, Leucine; Excitatory Amino Acid Agonists; Male; Mice; Morphine; N-Methylaspartate; Naltrexone; Narcotic Antagonists; Pain Measurement; Receptors, Opioid, delta; Spinal Cord | 2001 |
Beta-endorphin-induced feeding: pharmacological characterization using selective opioid antagonists and antisense probes in rats.
Topics: Analgesics, Opioid; Animals; Antisense Elements (Genetics); beta-Endorphin; Cloning, Molecular; Dose-Response Relationship, Drug; Eating; Exons; Feeding Behavior; Male; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta | 2001 |
Inhibition of morphine withdrawal by the NMDA receptor antagonist MK-801 in rat is age-dependent.
Topics: Age Factors; Animals; Body Temperature; Body Weight; Central Nervous System; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Administration Routes; Excitatory Amino Acid Antagonists; Male; Morphine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Long-Evans; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome | 2001 |
TRK-820, a selective kappa-opioid agonist, produces potent antinociception in cynomolgus monkeys.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Behavior, Animal; Macaca fascicularis; Morphinans; Morphine; Naloxone; Naltrexone; Pain Measurement; Pentazocine; Pentobarbital; Receptors, Opioid, kappa; Spiro Compounds | 2001 |
Pharmacological characterization of the dermorphin analog [Dmt(1)]DALDA, a highly potent and selective mu-opioid peptide.
Topics: Analgesics; Animals; Drug Tolerance; Humans; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Oligodeoxyribonucleotides, Antisense; Oligopeptides; Opioid Peptides; Pain Measurement; Receptors, Opioid, mu; Time Factors | 2001 |
Acute opioid pretreatment potentiates naltrexone-induced drinking suppression in water-deprived rats.
Topics: Analgesics, Opioid; Animals; Area Under Curve; Discrimination, Psychological; Dose-Response Relationship, Drug; Drinking; Fentanyl; Male; Meperidine; Morphine; Naltrexone; Narcotic Antagonists; Pain Measurement; Rats; Rats, Sprague-Dawley; Water Deprivation | 2001 |
Chronic exposure to mu-opioid agonists produces constitutive activation of mu-opioid receptors in direct proportion to the efficacy of the agonist used for pretreatment.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Analgesics, Opioid; Animals; Binding Sites; Cells, Cultured; Cyclic AMP; Down-Regulation; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Receptors, Opioid, mu; Sulfur Radioisotopes; Transfection; Virulence Factors, Bordetella | 2001 |
Inverse agonists and neutral antagonists at mu opioid receptor (MOR): possible role of basal receptor signaling in narcotic dependence.
Topics: Analgesics, Opioid; Animals; Benzylidene Compounds; Cell Line; Cell Membrane; Cyclic AMP; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Kidney; Magnesium; Male; Mice; Mice, Inbred ICR; Morphine; Morphine Dependence; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Receptors, Opioid, mu; Signal Transduction; Substance Withdrawal Syndrome; Sulfur Radioisotopes; Transfection; Tritium | 2001 |
Single nucleotide polymorphisms in the human mu opioid receptor gene alter basal G protein coupling and calmodulin binding.
Topics: Calmodulin; Cells, Cultured; Cyclic AMP; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Magnesium; Morphine; Naltrexone; Polymorphism, Genetic; Receptors, Opioid, mu | 2001 |
SoRI 9409, a non-peptide opioid mu receptor agonist/delta receptor antagonist, fails to stimulate [35S]-GTP-gamma-S binding at cloned opioid receptors.
Topics: Analgesics; Analgesics, Opioid; Animals; Benzamides; Benzeneacetamides; Binding, Competitive; CHO Cells; Cloning, Molecular; Cricetinae; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Iodine Radioisotopes; Morphine; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Piperazines; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sulfur Radioisotopes; Tritium | 2001 |
Critical role of mast cells in morphine-mediated impairment of zymosan-induced peritonitis in mice.
Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents; Bone Marrow Cells; Capillary Permeability; Cell Count; Chemotaxis, Leukocyte; Histamine; Male; Mast Cells; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; Morphine; Naltrexone; Narcotic Antagonists; Peritonitis; Zymosan | 2001 |
Parallel synthesis and biological activity of a new class of high affinity and selective delta-opioid ligand.
Topics: Amides; Analgesics, Opioid; Animals; Benzamides; Brain; Catalysis; Combinatorial Chemistry Techniques; Guinea Pigs; Humans; Inhibitory Concentration 50; Isoquinolines; Ligands; Male; Maleimides; Membrane Proteins; Mice; Mice, Inbred ICR; Molecular Structure; Morphine; Naltrexone; Nerve Tissue Proteins; Pain Measurement; Phthalimides; Piperazines; Quinolines; Rats; Rats, Wistar; Receptors, Opioid, delta; Structure-Activity Relationship; Succinimides; Sulfonamides | 2001 |
Kappa-opioid receptors on lymphocytes of a human lymphocytic cell line: morphine-induced up-regulation as evidenced by competitive RT-PCR and indirect immunofluorescence.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Cell Line; Fluorescent Antibody Technique, Indirect; Humans; Lymphocytes; Morphine; Naltrexone; Narcotic Antagonists; Receptors, Opioid, kappa; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Up-Regulation | 2001 |
Opioid system diversity in developing neurons, astroglia, and oligodendroglia in the subventricular zone and striatum: impact on gliogenesis in vivo.
Topics: Aging; Amino Acid Transport System X-AG; Animals; Animals, Newborn; Antigens, Differentiation; Antigens, Surface; Astrocytes; Bromodeoxyuridine; Calcium-Binding Proteins; Cell Differentiation; Cell Division; Glial Fibrillary Acidic Protein; Immunohistochemistry; Lateral Ventricles; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Neostriatum; Nerve Growth Factors; Neurons; Oligodendroglia; Opioid Peptides; Receptors, Opioid; S100 Calcium Binding Protein beta Subunit; S100 Proteins | 2001 |
Effectiveness of repeated administration of a new oral naltrexone controlled-release system on morphine analgesia.
Topics: Administration, Oral; Animals; Delayed-Action Preparations; Drug Administration Schedule; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Pain | 2001 |
Administration of mu-, kappa- or delta2-receptor agonists via osmotic minipumps suppresses murine splenic antibody responses.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Antibody Formation; Depression, Chemical; Dose-Response Relationship, Drug; Female; Immunosuppressive Agents; Infusion Pumps; Mice; Mice, Inbred C3H; Morphine; Naltrexone; Neuroimmunomodulation; Oligopeptides; Osmosis; Peptide Fragments; Peptides; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin; Spleen | 2001 |
Cholera toxin-B subunit blocks excitatory opioid receptor-mediated hyperalgesic effects in mice, thereby unmasking potent opioid analgesia and attenuating opioid tolerance/dependence.
Topics: Adjuvants, Immunologic; Administration, Oral; Analgesics, Opioid; Animals; Cells, Cultured; Cholera Toxin; Drug Administration Schedule; Drug Tolerance; Hot Temperature; Hyperalgesia; Injections, Subcutaneous; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Pain Measurement; Receptors, Opioid; Substance Withdrawal Syndrome | 2001 |
Interaction of morphine and naltrexone on oral ethanol self-administration in rhesus monkeys.
Topics: Alcohol Drinking; Analgesics, Opioid; Animals; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Interactions; Macaca mulatta; Male; Morphine; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu; Reinforcement, Psychology | 2001 |
Effect of opioids on oral Salmonella infection and immune function.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Drug Implants; Female; Immunosuppressive Agents; Infusion Pumps, Implantable; Mice; Mice, Inbred C3H; Morphine; Mouth Diseases; Naltrexone; Narcotic Antagonists; Narcotics; Oligopeptides; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Salmonella Infections, Animal; Salmonella typhimurium | 2001 |
Morphine upregulates kappa-opioid receptors of human lymphocytes.
Topics: Animals; Cell Line; Humans; Hybrid Cells; Immunosuppressive Agents; Lymphocytes; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, kappa; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Up-Regulation | 2001 |
Naltrexone microspheres: in vitro release and effect on morphine analgesia in mice.
Topics: Analgesia; Animals; Delayed-Action Preparations; Female; Lactic Acid; Mice; Microspheres; Morphine; Naltrexone; Narcotic Antagonists; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers | 2001 |
Rapid elevation of plasma interleukin-6 by morphine is dependent on autonomic stimulation of adrenal gland.
Topics: Adrenal Glands; Adrenal Medulla; Adrenalectomy; Animals; Autonomic Nervous System; Chlorisondamine; Corticosterone; Dose-Response Relationship, Drug; Ganglionic Blockers; Injections, Intraventricular; Interleukin-6; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Sprague-Dawley; Stimulation, Chemical | 2002 |
Methadone enhances human immunodeficiency virus infection of human immune cells.
Topics: Adult; Drug Interactions; Fetus; HIV Infections; Humans; Immunosuppressive Agents; Macrophages; Methadone; Microglia; Middle Aged; Monocytes; Morphine; Naltrexone; Narcotics; Receptors, CCR5 | 2002 |
Central discriminative effects of morphine in rats: training via intracerebroventricular administration.
Topics: Animals; Brain; Discrimination Learning; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Interactions; Enzyme Inhibitors; Injections, Intraventricular; Injections, Subcutaneous; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Opioid Peptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid | 2001 |
Comparison of the peripheral and central effects of the opioid agonists loperamide and morphine in the formalin test in rats.
Topics: Analgesics, Opioid; Animals; Antidiarrheals; Cisterna Magna; Dose-Response Relationship, Drug; Formaldehyde; Injections; Injections, Subcutaneous; Loperamide; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2002 |
Effect of precipitated morphine withdrawal on post-translational processing of prothyrotropin releasing hormone (proTRH) in the ventrolateral column of the midbrain periaqueductal gray.
Topics: Animals; Blotting, Western; Brain Chemistry; Electrophoresis, Polyacrylamide Gel; Hypothalamus; Immunohistochemistry; Male; Median Eminence; Morphine; Naltrexone; Paraventricular Hypothalamic Nucleus; Peptide Fragments; Periaqueductal Gray; Proprotein Convertase 2; Protein Precursors; Protein Processing, Post-Translational; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Subtilisins; Thyrotropin-Releasing Hormone; Up-Regulation | 2002 |
Regional and cellular mapping of cAMP response element-mediated transcription during naltrexone-precipitated morphine withdrawal.
Topics: Amygdala; Animals; beta-Galactosidase; Corticotropin-Releasing Hormone; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Female; Genes, Reporter; Locus Coeruleus; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Morphine; Naltrexone; Nucleus Accumbens; Raphe Nuclei; Receptors, Opioid, mu; Response Elements; Substance Withdrawal Syndrome; Transcription, Genetic; Tyrosine 3-Monooxygenase; Up-Regulation; Ventral Tegmental Area | 2002 |
Motivational effects mu- and kappa-opioid agonists following acute and chronic restraint stress: involvement of dopamine D(1) and D(2) receptors.
Topics: Acute Disease; Animals; Behavior, Animal; Benzomorphans; Chronic Disease; Conditioning, Operant; Injections, Intraventricular; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stress, Psychological | 2002 |
Delta opioid inhibition of light-induced phase advances in hamster circadian activity rhythms.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzamides; Biological Clocks; Circadian Rhythm; Cricetinae; Enkephalins; Light; Male; Mesocricetus; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Nerve Tissue Proteins; Opioid Peptides; Piperazines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Suprachiasmatic Nucleus | 2002 |
Antagonism of the antinociceptive and discriminative stimulus effects of heroin and morphine by 3-methoxynaltrexone and naltrexone in rhesus monkeys.
Topics: Analgesics; Analgesics, Opioid; Animals; Cues; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Heroin; Hot Temperature; Kinetics; Macaca mulatta; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain Measurement; Substance-Related Disorders | 2002 |
Differential morphine tolerance development in the modulation of macrophage cytokine production in mice.
Topics: Analgesics, Opioid; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Drug Tolerance; Interleukin-10; Interleukin-12; Kinetics; Macrophages; Male; Mice; Mice, Inbred BALB C; Morphine; Naltrexone; Narcotic Antagonists | 2002 |
Serum naltrexone and 6-beta-naltrexol levels from naltrexone implants can block very large amounts of heroin: a report of two cases.
Topics: Adult; Delayed-Action Preparations; Dose-Response Relationship, Drug; Drug Implants; Half-Life; Heroin; Heroin Dependence; Humans; Male; Morphine; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Patient Dropouts | 2002 |
Possible involvement of mu1-opioid receptors in the fentanyl- or morphine-induced antinociception at supraspinal and spinal sites.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Fentanyl; Injections, Intraventricular; Injections, Spinal; Injections, Subcutaneous; Male; Mice; Mice, Inbred C57BL; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Receptors, Opioid, mu; Spinal Cord | 2002 |
Effects of opioid antagonists on unconditioned and conditioned hyperactivity to morphine.
Topics: Analgesics, Opioid; Animals; Conditioning, Operant; Dose-Response Relationship, Drug; Hyperkinesis; Male; Morphine; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2002 |
Chronic agonist treatment converts antagonists into inverse agonists at delta-opioid receptors.
Topics: Adenylyl Cyclases; Analgesics, Opioid; Animals; Cell Line; Cell Membrane; Drug Tolerance; Enkephalin, D-Penicillamine (2,5)-; Guanosine 5'-O-(3-Thiotriphosphate); Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Receptors, Opioid, delta; Receptors, Opioid, mu | 2002 |
Influence of acute or repeated restraint stress on morphine-induced locomotion: involvement of dopamine, opioid and glutamate receptors.
Topics: Acute Disease; Animals; Benzazepines; Chronic Disease; Dizocilpine Maleate; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Excitatory Amino Acid Antagonists; Male; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Wistar; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Restraint, Physical; Stress, Psychological; Sulpiride | 2002 |
Lack of the nociceptin receptor does not affect acute or chronic nociception in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Female; Male; Mice; Mice, Knockout; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptin; Nociceptin Receptor; Oligopeptides; Opioid Peptides; Pain; Receptors, Opioid; Time Factors; Vas Deferens | 2002 |
Morphine regulates gene expression of alpha- and beta-chemokines and their receptors on astroglial cells via the opioid mu receptor.
Topics: Adjuvants, Immunologic; Astrocytes; Astrocytoma; Cells, Cultured; Chemokine CCL4; Chemokines, CC; Chemokines, CXC; Down-Regulation; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Humans; Immunophenotyping; Interleukin-8; Macrophage Inflammatory Proteins; Morphine; Naltrexone; Receptors, CCR3; Receptors, CCR5; Receptors, Chemokine; Receptors, Interleukin-8B; Receptors, Opioid, mu; Tumor Cells, Cultured; Up-Regulation | 2002 |
Pharmacology of opioid inhibition to noxious uterine cervical distension.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Cervix Uteri; Dose-Response Relationship, Drug; Electromyography; Female; Hemodynamics; Morphine; Naltrexone; Narcotic Antagonists; Ovariectomy; Pain Threshold; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Uterus | 2002 |
Kappa opioid antagonist effects of the novel kappa antagonist 5'-guanidinonaltrindole (GNTI) in an assay of schedule-controlled behavior in rhesus monkeys.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Non-Narcotic; Animals; Benzamides; Benzeneacetamides; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Interactions; Female; Guanidines; Macaca mulatta; Male; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Piperazines; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Reinforcement Schedule; Time Factors | 2002 |
Focal kappa-opioid receptor-mediated dependence and withdrawal in the nucleus paragigantocellularis.
Topics: Animals; Basal Ganglia; Butorphanol; Diffusion; Electric Stimulation; Male; Microinjections; Morphine; Morphine Dependence; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Stereotaxic Techniques; Stereotyped Behavior; Substance Withdrawal Syndrome | 2002 |
GABAergic and glutamatergic afferents in the dorsal raphe nucleus mediate morphine-induced increases in serotonin efflux in the rat central nervous system.
Topics: Analgesics, Opioid; Animals; Central Nervous System; Excitatory Amino Acid Agonists; GABA Agonists; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Glutamic Acid; Male; Microdialysis; Microinjections; Morphine; Muscimol; Naltrexone; Narcotic Antagonists; Neurons, Afferent; Nucleus Accumbens; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Serotonin | 2002 |
Morphine enhances HIV infection of human blood mononuclear phagocytes through modulation of beta-chemokines and CCR5 receptor.
Topics: Chemokines, CC; DNA Replication; DNA, Viral; Dose-Response Relationship, Drug; HIV; Humans; Macrophages; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Phagocytosis; Receptors, CCR5; Species Specificity; Up-Regulation; Virus Replication | 2002 |
Potency differences for D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 as an antagonist of peptide and alkaloid micro-agonists in an antinociception assay.
Topics: Alkaloids; Analgesics, Opioid; Animals; Binding, Competitive; Buprenorphine; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Etorphine; Injections, Intraventricular; Injections, Subcutaneous; Male; Morphine; Naltrexone; Narcotic Antagonists; Opioid Peptides; Pain Measurement; Peptide Fragments; Peptides; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid, mu; Somatostatin | 2003 |
Activity of opioid ligands in cells expressing cloned mu opioid receptors.
Topics: Azocines; beta-Endorphin; Binding, Competitive; Butorphanol; Cell Line; Colforsin; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Etorphine; Fentanyl; Humans; Hydromorphone; Ligands; Morphine; Naltrexone; Phenazocine; Radioligand Assay; Receptors, Opioid, mu; Tritium | 2003 |
Effects of beta-funaltrexamine and naloxonazine on single-trial morphine-conditioned place preference and locomotor activity.
Topics: Animals; Conditioning, Psychological; Male; Morphine; Motor Activity; Naloxone; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 2003 |
Role of kappa-opioid receptor activation in pharmacological preconditioning of swine.
Topics: Animals; Arrhythmias, Cardiac; Coronary Circulation; Enkephalin, Leucine-2-Alanine; Hemodynamics; Ischemic Preconditioning, Myocardial; Morphine; Myocardial Infarction; Myocardial Ischemia; Naltrexone; Narcotic Antagonists; Narcotics; Pentazocine; Receptors, Opioid, kappa; Swine | 2003 |
Discriminative stimulus and antinociceptive effects of dihydroetorphine in rhesus monkeys.
Topics: Analgesics, Opioid; Animals; Discrimination Learning; Etorphine; Female; Macaca mulatta; Male; Morphine; Naltrexone | 2003 |
Discrimination of a single dose of morphine followed by naltrexone: substitution of other agonists for morphine and other antagonists for naltrexone in a rat model of acute dependence.
Topics: Acute Disease; Analgesics, Opioid; Animals; Disease Models, Animal; Fentanyl; Male; Methadone; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Substance-Related Disorders | 2003 |
Adenosine and opioid receptor-mediated cardioprotection in the rat: evidence for cross-talk between receptors.
Topics: Adenosine; Analgesics, Opioid; Animals; ATP-Binding Cassette Transporters; Benzylidene Compounds; Free Radicals; Heart Diseases; In Vitro Techniques; KATP Channels; Mitochondria, Heart; Morphine; Myocardial Infarction; Myocardial Reperfusion Injury; Naltrexone; Potassium Channels; Potassium Channels, Inwardly Rectifying; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptor Cross-Talk; Receptors, Opioid, delta; Receptors, Purinergic P1 | 2003 |
Opioid agonists have different efficacy profiles for G protein activation, rapid desensitization, and endocytosis of mu-opioid receptors.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Electric Conductivity; Endocytosis; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; GTP-Binding Proteins; Methadone; Mice; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Neuroblastoma; Pentazocine; Pituitary Neoplasms; Receptors, Opioid, mu; Transfection; Tumor Cells, Cultured | 2003 |
Discriminative stimulus effects of acute morphine followed by naltrexone in the squirrel monkey.
Topics: Animals; Benzeneacetamides; Conditioning, Operant; Dextrorphan; Discrimination Learning; Dose-Response Relationship, Drug; Generalization, Psychological; Levorphanol; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pyrrolidines; Receptors, Opioid; Saimiri; Substance Withdrawal Syndrome | 2003 |
Use of irreversible antagonists to determine the relative efficacy of mu-opioids in a pigeon drug discrimination procedure: comparison of beta-funaltrexamine and clocinnamox.
Topics: Animals; Cinnamates; Columbidae; Female; Fentanyl; Methadone; Morphine; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Narcotics; Reaction Time; Receptors, Opioid, mu; Sufentanil | 2003 |
Activation of kappa-opioid receptors inhibits pruritus evoked by subcutaneous or intrathecal administration of morphine in monkeys.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Disease Models, Animal; Drug Interactions; Female; Injections, Spinal; Injections, Subcutaneous; Macaca mulatta; Male; Morphine; Naltrexone; Narcotic Antagonists; Pruritus; Receptors, Opioid, kappa | 2003 |
Regulation of RGS proteins by chronic morphine in rat locus coeruleus.
Topics: Animals; Blotting, Western; Immunohistochemistry; In Situ Hybridization; Locus Coeruleus; Male; Membrane Potentials; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Neurons; Organ Culture Techniques; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; RGS Proteins; RNA, Messenger; Substance Withdrawal Syndrome | 2003 |
Effects of heroin and its metabolites on schedule-controlled responding and thermal nociception in rhesus monkeys: sensitivity to antagonism by quadazocine, naltrindole and beta-funaltrexamine.
Topics: Animals; Azocines; Behavior, Animal; Dose-Response Relationship, Drug; Food; Heroin; Hot Temperature; Macaca mulatta; Morphine; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Pain Measurement | 2003 |
Opioids and the apoptotic pathway in human cancer cells.
Topics: Annexin A5; Apoptosis; Cell Adhesion; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Etorphine; Growth Substances; Humans; In Situ Nick-End Labeling; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Necrosis; Neoplasms; Tumor Cells, Cultured | 2003 |
Relative efficacy of buprenorphine, nalbuphine and morphine in opioid-treated rhesus monkeys discriminating naltrexone.
Topics: Animals; Buprenorphine; Conditioning, Operant; Discrimination Learning; Female; Macaca mulatta; Male; Methadyl Acetate; Morphine; Nalbuphine; Naltrexone; Narcotics; Receptors, Opioid, mu | 2003 |
Effects of in vitro and in vivo opioids on the production of IL-12 and IL-10 by murine macrophages.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enzyme-Linked Immunosorbent Assay; Interleukin-10; Interleukin-12; Macrophages, Peritoneal; Male; Mice; Mice, Inbred BALB C; Morphine; Naltrexone; Pain | 2003 |
Morphine withdrawal precipitated by specific mu, delta or kappa opioid receptor antagonists: a c-Fos protein study in the rat central nervous system.
Topics: Animals; Behavior, Animal; Cell Count; Central Nervous System; Gene Expression Regulation; Immunohistochemistry; Male; Morphine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Narcotics; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 2003 |
Morphine enhances hepatitis C virus (HCV) replicon expression.
Topics: Antiviral Agents; Enzyme Activation; Gene Expression; Hepacivirus; Humans; Interferon-alpha; Morphine; Naltrexone; Narcotic Antagonists; NF-kappa B; Receptors, Opioid, mu; Replicon; RNA, Messenger; Tumor Cells, Cultured | 2003 |
Expression of EGFP-amino-tagged human mu opioid receptor in Drosophila Schneider 2 cells: a potential expression system for large-scale production of G-protein coupled receptors.
Topics: Animals; Binding, Competitive; Blotting, Western; Cell Line; Cloning, Molecular; Colforsin; Copper Sulfate; Cyclic AMP; Diprenorphine; DNA, Complementary; Drosophila; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Gene Expression; Genetic Vectors; Green Fluorescent Proteins; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Luminescent Proteins; Metallothionein; Microscopy, Confocal; Morphine; Naloxone; Naltrexone; Oligopeptides; Opioid Peptides; Pertussis Toxin; Polymerase Chain Reaction; Protein Binding; Receptors, G-Protein-Coupled; Receptors, Opioid, mu; Recombinant Fusion Proteins; Spectrometry, Fluorescence; Thermodynamics | 2003 |
Blood morphine levels in naltrexone-exposed compared to non-naltrexone-exposed fatal heroin overdoses.
Topics: Adult; Australia; Cohort Studies; Drug Overdose; Female; Heroin; Heroin Dependence; Humans; Male; Morphine; Naltrexone; Narcotic Antagonists; Registries; Retrospective Studies; Time Factors | 2003 |
Involvement of central mu-opioid system in the scratching behavior in mice, and the suppression of it by the activation of kappa-opioid system.
Topics: Animals; Antipruritics; Behavior, Animal; Injections, Intraventricular; Injections, Subcutaneous; Ketotifen; Male; Mice; Morphinans; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Pruritus; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spiro Compounds; Substance P | 2003 |
Dynorphinergic mechanism mediating endomorphin-2-induced antianalgesia in the mouse spinal cord.
Topics: Analgesics, Opioid; Animals; Antibodies, Blocking; Dizocilpine Maleate; Dose-Response Relationship, Drug; Dynorphins; Excitatory Amino Acid Antagonists; Injections, Spinal; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain Measurement; Reaction Time; Receptors, Opioid; Spinal Cord | 2003 |
Characterization of scratching responses in rats following centrally administered morphine or bombesin.
Topics: Analgesics, Opioid; Animals; Antipruritics; Bombesin; Brain; Dose-Response Relationship, Drug; Grooming; Injections, Intraventricular; Injections, Spinal; Male; Morphine; Naltrexone; Narcotic Antagonists; Premedication; Rats; Rats, Wistar; Receptors, Opioid, mu; Spinal Cord; Stereotyped Behavior | 2003 |
Methylnaltrexone antagonizes opioid-mediated enhancement of HIV infection of human blood mononuclear phagocytes.
Topics: Cells, Cultured; HIV Infections; HIV Reverse Transcriptase; Humans; Monocytes; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Quaternary Ammonium Compounds; Receptors, CCR5 | 2003 |
Cocaine and other indirect-acting monoamine agonists differentially attenuate a naltrexone discriminative stimulus in morphine-treated rhesus monkeys.
Topics: Amphetamine; Animals; Biogenic Monoamines; Cocaine; Discrimination Learning; Disease Models, Animal; Dopamine Agents; Dopamine Uptake Inhibitors; Drug Interactions; Imipramine; Macaca mulatta; Morphine; Morphine Dependence; Naltrexone; Narcotics; Substance Withdrawal Syndrome | 2004 |
Effect of opioid receptor ligands on the mu-S196A knock-in and mu knockout mouse vas deferens.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Enkephalin, Leucine-2-Alanine; In Vitro Techniques; Ligands; Male; Mice; Mice, Knockout; Mice, Transgenic; Morphine; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Receptors, Opioid; Vas Deferens | 2003 |
Basal signaling activity of mu opioid receptor in mouse brain: role in narcotic dependence.
Topics: Adenylyl Cyclases; Animals; Brain; Disease Models, Animal; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice; Mice, Inbred ICR; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Receptors, Opioid, mu; Signal Transduction; Substance Withdrawal Syndrome; Sulfur Radioisotopes | 2004 |
Delta opioid receptors are involved in morphine-induced inhibition of luteinizing hormone releasing hormone in SK-N-SH cells.
Topics: Analgesics, Opioid; Cell Line, Tumor; Dose-Response Relationship, Drug; Gonadotropin-Releasing Hormone; Humans; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Neuroblastoma; Receptors, Opioid, delta; Somatostatin | 2003 |
Characterization and opioid modulation of inflammatory temporomandibular joint pain in the rat.
Topics: Analgesics, Opioid; Animals; Arthritis, Experimental; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Grooming; Head Movements; Male; Mastication; Morphine; Mustard Plant; Naltrexone; Narcotic Antagonists; Neural Pathways; Nociceptors; Pain; Plant Extracts; Plant Oils; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Temporomandibular Joint Disorders; Trigeminal Caudal Nucleus | 2003 |
[Comparison of the antagonistic effects of 6 beta-naltrexol and naltrexone against morphine analgesia].
Topics: Analgesia; Analgesics, Opioid; Animals; Female; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Pain Threshold; Receptors, Opioid, mu | 2003 |
Opioid partial agonist effects of 3-O-methylnaltrexone in rhesus monkeys.
Topics: Adenylyl Cyclases; Animals; Cocaine; Discrimination Learning; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Heroin; Heroin Dependence; Macaca mulatta; Male; Morphine; Morphine Derivatives; Naltrexone; Narcotics; Quaternary Ammonium Compounds; Receptors, Opioid, mu; Self Administration | 2004 |
Opioid modulation of scratching and spinal c-fos expression evoked by intradermal serotonin.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Hindlimb; Injections, Intradermal; Male; Microinjections; Morphine; Naltrexone; Narcotic Antagonists; Neck; Posterior Horn Cells; Proto-Oncogene Proteins c-fos; Pruritus; Rats; Rats, Sprague-Dawley; Serotonin; Spinal Cord | 2003 |
Sex differences in opioid-induced enhancement of contact hypersensitivity.
Topics: Animals; Buprenorphine; Castration; Dermatitis, Contact; Etorphine; Female; Gonadal Steroid Hormones; Male; Morphine; Naltrexone; Rats; Rats, Inbred F344; Receptors, Opioid, mu; Sex Characteristics | 2003 |
Effects of morphine and naltrexone on impulsive decision making in rats.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Behavior, Animal; Decision Making; Dose-Response Relationship, Drug; Drug Interactions; Impulsive Behavior; Male; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley | 2004 |
Nonopioidergic mechanism mediating morphine-induced antianalgesia in the mouse spinal cord.
Topics: Analgesia; Animals; beta-Endorphin; Dizocilpine Maleate; Drug Interactions; Drug Tolerance; Dynorphins; Enkephalins; Male; Mice; Morphine; Naloxone; Naltrexone; Oligopeptides; Pain; Pain Measurement; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord; Substance P | 2004 |
Application of a simple and sensitive GC-MS method for determination of morphine in the hair of opium abusers.
Topics: Adult; Gas Chromatography-Mass Spectrometry; Hair; Humans; Iran; Male; Middle Aged; Morphine; Morphine Derivatives; Naltrexone; Opium; Reproducibility of Results; Solvents; Substance Abuse Detection; Time Factors | 2004 |
Methylnaltrexone prevents morphine-induced kaolin intake in the rat.
Topics: Animals; Antiemetics; Diet; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Injections, Intraperitoneal; Kaolin; Male; Morphine; Naltrexone; Narcotic Antagonists; Ondansetron; Pica; Quaternary Ammonium Compounds; Rats; Rats, Wistar | 2004 |
Supraspinal and spinal cord opioid receptors are responsible for antinociception following intrathecal morphine injections.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Injections, Spinal; Male; Models, Animal; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Pain; Pain Threshold; Random Allocation; Rats; Rats, Wistar; Reaction Time; Receptors, Opioid; Spinal Cord; Tail | 2004 |
Naltrexone antagonism of morphine antinociception in sucrose- and chow-fed rats.
Topics: Analgesics, Opioid; Animal Feed; Animals; Dietary Sucrose; Energy Intake; Male; Morphine; Naltrexone; Pain; Rats; Rats, Long-Evans; Reaction Time | 2004 |
Potentiated startle and hyperalgesia during withdrawal from acute morphine: effects of multiple opiate exposures.
Topics: Acoustic Stimulation; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Hyperalgesia; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain Measurement; Rats; Rats, Sprague-Dawley; Reflex, Startle; Substance Withdrawal Syndrome | 2004 |
The antinociceptive effect of Delta9-tetrahydrocannabinol in the arthritic rat.
Topics: Animals; Arthritis, Experimental; Cannabinoid Receptor Antagonists; Dose-Response Relationship, Drug; Dronabinol; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Freund's Adjuvant; Injections, Intradermal; Injections, Intraperitoneal; Male; Morphine; Mycobacterium; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Opioid; Rimonabant | 2004 |
Interactions of "ultra-low" doses of naltrexone and morphine in mature and young male and female rats.
Topics: Age Factors; Analgesics, Opioid; Animals; Drug Interactions; Female; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Sex Factors | 2004 |
Direct evidence for the involvement of the mesolimbic kappa-opioid system in the morphine-induced rewarding effect under an inflammatory pain-like state.
Topics: Animals; Brain Chemistry; Conditioning, Operant; Dopamine; Dynorphins; Edema; Foot; Formaldehyde; Inflammation; Limbic System; Male; Microdialysis; Microinjections; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reward | 2005 |
The opioid antagonist naltrexone blocks acute endotoxic shock by inhibiting tumor necrosis factor-alpha production.
Topics: Analysis of Variance; Animals; Antibodies; Bacterial Toxins; Enterotoxins; fas Receptor; Interleukin-1; Interleukin-6; Lipopolysaccharides; Liver; Macrophages; Male; Mice; Mice, Inbred BALB C; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Shock, Septic; Survival Rate; Tumor Necrosis Factor-alpha | 2004 |
The interaction of cannabinoids and opioids on pentylenetetrazole-induced seizure threshold in mice.
Topics: Analysis of Variance; Animals; Arachidonic Acids; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cannabinoids; Differential Threshold; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Male; Mice; Mice, Inbred Strains; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Pentylenetetrazole; Piperidines; Pyrazoles; Reaction Time; Receptor, Cannabinoid, CB1; Receptors, Opioid; Seizures; Statistics, Nonparametric; Time Factors | 2004 |
Sex and estrus cycle differences in the modulatory effects of morphine on seizure susceptibility in mice.
Topics: Animals; Anticonvulsants; Convulsants; Disease Susceptibility; Dose-Response Relationship, Drug; Estrous Cycle; Female; Gonadal Steroid Hormones; Infusions, Intravenous; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Orchiectomy; Ovariectomy; Pentylenetetrazole; Seizures; Sex Factors | 2004 |
Obstructive cholestasis alters intestinal transit in mice: role of opioid system.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Cholestasis, Extrahepatic; Disease Models, Animal; Drug Therapy, Combination; Gastrointestinal Transit; Injections, Intraperitoneal; Injections, Subcutaneous; Intestine, Small; Male; Mice; Mice, Inbred Strains; Morphine; Naltrexone | 2004 |
Ultra-low dose naltrexone potentiates the anticonvulsant effect of low dose morphine on clonic seizures.
Topics: Animals; Differential Threshold; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Pentylenetetrazole; Reaction Time; Seizures | 2004 |
Interactions of galanin and opioids in nociceptive modulation in the arcuate nucleus of hypothalamus in rats.
Topics: Analgesics, Opioid; Animals; Arcuate Nucleus of Hypothalamus; Dose-Response Relationship, Drug; Galanin; Hindlimb; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Pain; Rats; Rats, Wistar; Receptors, Opioid | 2005 |
The development of tolerance to locomotor effects of morphine and the effect of various opioid receptor antagonists in rats chronically treated with morphine.
Topics: Animals; Behavior, Animal; Drug Interactions; Male; Morphine; Morphine Dependence; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Wistar; Time Factors | 2005 |
Lack of evidence for mu-opioid regulation of a socially mediated separation response.
Topics: Animals; Dose-Response Relationship, Drug; Female; Male; Maternal Deprivation; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Wistar; Receptors, Opioid, mu; Social Environment; Social Isolation; Ultrasonics; Vocalization, Animal | 2005 |
Characterisation of opioid receptors involved in modulating circular and longitudinal muscle contraction in the rat ileum.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enteric Nervous System; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Muscle Contraction; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu | 2005 |
In vivo characterization of 6beta-naltrexol, an opioid ligand with less inverse agonist activity compared with naltrexone and naloxone in opioid-dependent mice.
Topics: Animals; Benzylidene Compounds; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice; Mice, Inbred ICR; Morphine; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders | 2005 |
Sensitization to morphine withdrawal in guinea-pigs.
Topics: Amygdala; Analgesics, Opioid; Analysis of Variance; Animals; Behavior, Animal; Body Weight; Brain Chemistry; Cerebral Cortex; Guinea Pigs; Hippocampus; Hypothalamus; Immunohistochemistry; Male; Morphine; Motor Activity; Naltrexone; Proto-Oncogene Proteins c-fos; Rats; Substance Withdrawal Syndrome; Telencephalon; Time Factors | 2005 |
Naltrexone treatment of combined alcohol and opioid dependence: deterioration of co-morbid major depression.
Topics: Alcoholism; Amitriptyline; Depressive Disorder, Major; Ethanol; Humans; Male; Middle Aged; Morphine; Morphine Dependence; Naltrexone; Narcotics; Severity of Illness Index; Substance Withdrawal Syndrome | 2005 |
In vivo activation of a mutant mu-opioid receptor by naltrexone produces a potent analgesic effect but no tolerance: role of mu-receptor activation and delta-receptor blockade in morphine tolerance.
Topics: Animals; Benzamides; Dose-Response Relationship, Drug; Drug Delivery Systems; Drug Interactions; Drug Tolerance; Mice; Mice, Transgenic; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Pain Measurement; Piperazines; Receptors, Opioid, mu | 2005 |
Discriminative stimulus effects of acute morphine followed by naltrexone in the squirrel monkey: a further characterization.
Topics: Analgesics, Opioid; Animals; Buprenorphine; Diprenorphine; Discrimination, Psychological; Dose-Response Relationship, Drug; Drinking; Drug Interactions; Generalization, Stimulus; Male; Meperidine; Mice; Morphine; Nalbuphine; Nalorphine; Naltrexone; Narcotic Antagonists; Saimiri; Water Deprivation | 2005 |
Naltrexone-induced conditioned place aversion following a single dose of morphine in the rat.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Conditioning, Operant; Dose-Response Relationship, Drug; Male; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Time Factors | 2005 |
Opioid antagonists differ according to negative intrinsic efficacy in a mouse model of acute dependence.
Topics: Animals; Behavior, Animal; Body Weight; Brain; Diprenorphine; Dose-Response Relationship, Drug; Male; Mice; Morphine; Morphine Dependence; Naloxone; Naltrexone; Narcotic Antagonists; Substance Withdrawal Syndrome; Tremor | 2005 |
The role of central and peripheral mu opioid receptors in inflammatory pain and edema: a study using morphine and DiPOA ([8-(3,3-diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triaza-spiro[4.5]dec-3-yl]-acetic acid).
Topics: Acetates; Animals; Aza Compounds; Brain; Carrageenan; Edema; Injections, Intraventricular; Male; Morphine; Naltrexone; Pain; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Spiro Compounds | 2005 |
Effect of repeated administrations of heroin, naltrexone, methadone, and alcohol on morphine glucuronidation in the rat.
Topics: Animals; Ethanol; Heroin; Heroin Dependence; Male; Methadone; Microsomes, Liver; Morphine; Morphine Derivatives; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 2005 |
Morphine inhibits CD8+ T cell-mediated, noncytolytic, anti-HIV activity in latently infected immune cells.
Topics: Anti-HIV Agents; CD8-Positive T-Lymphocytes; Cell Line; HIV Infections; HIV-1; Humans; Interferon-gamma; Jurkat Cells; Morphine; Naltrexone; STAT1 Transcription Factor | 2005 |
In vitro electrophysiologic effects of morphine in rabbit ventricular myocytes.
Topics: Action Potentials; Animals; Calcium; Calcium Channels, L-Type; Female; In Vitro Techniques; Male; Morphine; Myocytes, Cardiac; Naltrexone; Potassium Channels; Rabbits | 2005 |
Evidence for an intrinsic mechanism of antinociceptive tolerance within the ventrolateral periaqueductal gray of rats.
Topics: Analgesics; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Formaldehyde; GABA Agonists; GABA-A Receptor Agonists; Male; Medulla Oblongata; Morphine; Muscimol; Naltrexone; Narcotic Antagonists; Neurons; Pain Measurement; Periaqueductal Gray; Rats; Rats, Sprague-Dawley | 2005 |
Effects of opioid antagonists and morphine in a hippocampal hypoxia/hypoglycemia model.
Topics: Analgesics, Opioid; Animals; Brain Chemistry; Evoked Potentials; Hippocampus; Hypoglycemia; Hypoxia, Brain; In Vitro Techniques; Male; Morphine; Naltrexone; Narcotic Antagonists; Neuroprotective Agents; Neurotoxicity Syndromes; Rats; Rats, Wistar; Reperfusion Injury | 2005 |
Barium potentiates the conditioned aversion to, but not the somatic signs of, morphine withdrawal in mice.
Topics: Animals; Barium; Behavior, Animal; Cerebral Cortex; Conditioning, Operant; Dopamine; Dose-Response Relationship, Drug; Drug Synergism; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Narcotic Antagonists; Norepinephrine; Prosencephalon; Substance Withdrawal Syndrome | 2005 |
Attenuation of post-ischemia reperfusion injury by thaliporphine and morphine in rat hearts.
Topics: Adenosine Triphosphate; Analgesics, Opioid; Animals; Antioxidants; Aporphines; Creatine Kinase; Dose-Response Relationship, Drug; Heart; Male; Mitochondria; Morphine; Myocardial Ischemia; Myocardium; Naloxone; Naltrexone; Narcotic Antagonists; Peroxidase; Plant Extracts; Potassium; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Risk; Time Factors | 2005 |
Habituation to test procedure modulates the involvement of dopamine D2- but not D1-receptors in ethanol-induced locomotor stimulation in mice.
Topics: Amphetamine; Animals; Benzazepines; beta-Endorphin; Caffeine; Environment; Ethanol; Exploratory Behavior; Habituation, Psychophysiologic; Male; Mice; Morphine; Motor Activity; Naltrexone; Receptors, Dopamine D1; Receptors, Dopamine D2; Sulpiride | 2005 |
Antinociception, tolerance and withdrawal symptoms induced by 7-hydroxymitragynine, an alkaloid from the Thai medicinal herb Mitragyna speciosa.
Topics: Analgesics; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Injections, Subcutaneous; Male; Mice; Mitragyna; Models, Molecular; Morphinans; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Reaction Time; Secologanin Tryptamine Alkaloids; Substance Withdrawal Syndrome; Thailand | 2005 |
Differential effects of morphine and naltrexone on the in vitro LH secretion from male and female carp pituitary gland.
Topics: Animals; Carps; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Luteinizing Hormone; Male; Morphine; Naltrexone; Narcotic Antagonists; Pituitary Gland | 2005 |
Chronic morphine treatment promotes specific Th2 cytokine production by murine T cells in vitro via a Fas/Fas ligand-dependent mechanism.
Topics: Animals; Antibodies; Apoptosis; Apoptosis Regulatory Proteins; Cell Differentiation; Cytokines; Fas Ligand Protein; fas Receptor; Female; Interleukin-13; Interleukin-4; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Morphine; Naltrexone; Narcotics; Receptors, Tumor Necrosis Factor; RNA, Messenger; Th2 Cells; TNF-Related Apoptosis-Inducing Ligand; Tumor Necrosis Factor-alpha; Tumor Necrosis Factors | 2005 |
Antinociceptive effect of oxycodone in diabetic mice.
Topics: Analgesics, Opioid; Animals; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Narcotic Antagonists; Oxycodone; Pain; Pain Measurement; Time Factors | 2005 |
Attenuation of morphine withdrawal signs by intracerebral administration of 18-methoxycoronaridine.
Topics: Animals; Brain; Drug Administration Routes; Female; Ibogaine; Locus Coeruleus; Morphine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 2005 |
Involvement of cAMP/cAMP-dependent protein kinase signaling pathway in regulation of Na+,K+-ATPase upon activation of opioid receptors by morphine.
Topics: Adenylyl Cyclases; Animals; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Down-Regulation; Enzyme Inhibitors; Hippocampus; Isoquinolines; Male; Mice; Mice, Inbred Strains; Molecular Mimicry; Morphine; Naltrexone; Okadaic Acid; Pertussis Toxin; Phosphoprotein Phosphatases; Protein Biosynthesis; Protein Kinase Inhibitors; Receptors, Opioid; Signal Transduction; Sodium-Potassium-Exchanging ATPase; Sulfonamides | 2006 |
Opioid-induced tolerance and dependence in mice is modulated by the distance between pharmacophores in a bivalent ligand series.
Topics: Analgesics; Analgesics, Opioid; Animals; Chemistry, Pharmaceutical; Dose-Response Relationship, Drug; Ligands; Male; Mice; Mice, Inbred ICR; Models, Chemical; Models, Statistical; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Receptors, Opioid, delta; Receptors, Opioid, mu; Time Factors | 2005 |
Elevated mu-opioid receptor expression in the nucleus of the solitary tract accompanies attenuated withdrawal signs after chronic low dose naltrexone in opiate-dependent rats.
Topics: Animals; Behavior, Animal; Blotting, Western; CREB-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Interactions; Gene Expression; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Prosencephalon; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Solitary Nucleus; Substance Withdrawal Syndrome; Time Factors | 2006 |
Morphine hyperalgesia in mice is unrelated to opioid activity, analgesia, or tolerance: evidence for multiple diverse hyperalgesic systems.
Topics: Analgesia; Analgesics, Opioid; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Tolerance; Excitatory Amino Acid Antagonists; Hyperalgesia; Injections, Subcutaneous; Male; Mice; Mice, Inbred Strains; Morphine; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Nociceptors; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid | 2006 |
Inhibition of morphine tolerance by processed Aconiti tuber is mediated by kappa-opioid receptors.
Topics: Aconitum; Analgesics, Opioid; Animals; Cinnamates; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Drugs, Chinese Herbal; Male; Mice; Morphine; Morphine Derivatives; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Pain Threshold; Plant Tubers; Receptors, Opioid, kappa; Time Factors | 2006 |
Involvements of mu- and kappa-opioid receptors in morphine-induced antinociception in the nucleus accumbens of rats.
Topics: Analgesics, Opioid; Animals; Male; Morphine; Naloxone; Naltrexone; Nucleus Accumbens; Pain; Physical Stimulation; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2006 |
Influence of low doses of naltrexone on morphine antinociception and morphine tolerance in male and female rats of four strains.
Topics: Analgesics; Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Combinations; Drug Synergism; Drug Tolerance; Female; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain; Pain Threshold; Rats; Rats, Inbred F344; Rats, Long-Evans; Rats, Sprague-Dawley; Sex Factors; Species Specificity | 2006 |
Opioid receptors in the nucleus accumbens regulate attentional learning in the blocking paradigm.
Topics: Analgesics, Opioid; Animals; Attention; Electroshock; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Learning; Male; Models, Animal; Morphine; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Physical Stimulation; Rats; Rats, Wistar; Receptors, Opioid | 2006 |
Endogenous opioids mediate the hypoalgesia induced by selective inhibitors of cyclo-oxygenase 2 in rat paws treated with carrageenan.
Topics: Analgesics; Analgesics, Opioid; Animals; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Drug Tolerance; Edema; Endorphins; Foot; Hyperalgesia; Indomethacin; Injections; Injections, Subcutaneous; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Pyrazoles; Rats; Rats, Sprague-Dawley; Rats, Wistar; Signal Transduction; Species Specificity | 2006 |
The involvement of endogenous opioid mechanisms in the antinociceptive effects induced by antidepressant drugs, desipramine and trimipramine.
Topics: Analgesics; Animals; Antidepressive Agents; Desipramine; Male; Mice; Morphine; Naloxone; Naltrexone; Receptors, Opioid; Receptors, Opioid, delta; Trimipramine | 2006 |
Chronic morphine treatment induces oxidant and apoptotic damage in the mice liver.
Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Cell Survival; Chronic Disease; Glutathione; Liver; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Oxidative Stress; Pain; Signal Transduction | 2006 |
Food-induced behavioral sensitization, its cross-sensitization to cocaine and morphine, pharmacological blockade, and effect on food intake.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analgesics, Opioid; Animals; Benzazepines; Benzodiazepines; Cocaine; Conditioning, Psychological; Dopamine Antagonists; Dopamine Uptake Inhibitors; Drug Interactions; Eating; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Feeding Behavior; Male; Mice; Mice, Inbred C57BL; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Receptors, Dopamine D1; Sulpiride | 2006 |
Noradrenaline is necessary for the hedonic properties of addictive drugs.
Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Appetitive Behavior; Benzazepines; Biphenyl Compounds; Bupropion; Carbidopa; Cocaine; Dopamine beta-Hydroxylase; Dopamine Uptake Inhibitors; Droxidopa; Female; Genotype; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Knockout; Morphine; Naltrexone; Narcotic Antagonists; Neurokinin-1 Receptor Antagonists; Norepinephrine; Receptors, Adrenergic, alpha-1; Receptors, Dopamine D1; Reward; Substance-Related Disorders | 2006 |
Involvement of mu-opioid receptors in antinociception and inhibition of gastrointestinal transit induced by 7-hydroxymitragynine, isolated from Thai herbal medicine Mitragyna speciosa.
Topics: Analgesics; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Gastrointestinal Transit; Guinea Pigs; Herbal Medicine; Ileum; Male; Mice; Mitragyna; Molecular Structure; Morphine; Muscle Contraction; Naltrexone; Narcotic Antagonists; Narcotics; Pain; Pain Measurement; Receptors, Opioid, mu; Secologanin Tryptamine Alkaloids; Thailand; Vas Deferens | 2006 |
Morphine upregulates functional expression of neurokinin-1 receptor in neurons.
Topics: Analysis of Variance; Animals; Blotting, Western; Calcium; Cerebral Cortex; Drug Interactions; Embryo, Mammalian; Enzyme Activation; Enzyme Inhibitors; Fluorescent Antibody Technique; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Neurons; p38 Mitogen-Activated Protein Kinases; Peptide Fragments; Peptides; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Opioid, mu; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Somatostatin; Up-Regulation | 2006 |
Expression and localization of delta-, kappa-, and mu-opioid receptors in human spermatozoa and implications for sperm motility.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adult; Analgesics, Opioid; Humans; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sperm Motility; Spermatozoa; Tissue Distribution | 2006 |
In vivo pharmacological resultant analysis reveals noncompetitive interactions between opioid antagonists in the rat tail-withdrawal assay.
Topics: Algorithms; Animals; Dose-Response Relationship, Drug; Drug Interactions; Injections, Intraventricular; Injections, Subcutaneous; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Pain Measurement; Peptide Fragments; Peptides; Rats; Rats, Sprague-Dawley; Reaction Time; Somatostatin | 2006 |
Different effects of opioid antagonists on mu-, delta-, and kappa-opioid receptors with and without agonist pretreatment.
Topics: Benzylidene Compounds; Cells, Cultured; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Morphine; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Signal Transduction | 2007 |
Local opioids in a model of periodontal disease in rats.
Topics: Alveolar Bone Loss; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Gingiva; Injections; Injections, Subcutaneous; Leukocyte Count; Male; Morphine; Naltrexone; Narcotic Antagonists; Neutrophils; Periodontal Attachment Loss; Periodontal Diseases; Rats; Rats, Sprague-Dawley; Receptors, Opioid | 2007 |
Inhibition of tolerance to spinal morphine antinociception by low doses of opioid receptor antagonists.
Topics: Animals; Dose-Response Relationship, Drug; Drug Tolerance; Hyperalgesia; Injections, Spinal; Male; Morphine; Naltrexone; Narcotic Antagonists; Peptide Fragments; Peptides; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Somatostatin; Theophylline | 2007 |
Nucleus accumbens opioid signaling conditions short-term flavor preferences.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Behavior, Animal; Conditioning, Operant; Eating; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Food Preferences; GABA Agonists; Male; Morphine; Muscimol; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Rats; Rats, Long-Evans; Signal Transduction; Taste; Time Factors | 2007 |
History of cocaine self-administration alters morphine reinforcement in the rat.
Topics: Analysis of Variance; Animals; Cocaine; Conditioning, Operant; Dose-Response Relationship, Drug; Infusions, Intravenous; Injections, Intraperitoneal; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Self Administration | 2007 |
The in vitro pharmacology of the peripherally restricted opioid receptor antagonists, alvimopan, ADL 08-0011 and methylnaltrexone.
Topics: Analgesics, Opioid; Animals; Benzeneacetamides; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Morphine; Muscle Contraction; Naltrexone; Narcotic Antagonists; Oligopeptides; Piperidines; Pyrrolidines; Quaternary Ammonium Compounds; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Proteins; Transfection | 2007 |
Lobeline, a potential pharmacotherapy for drug addiction, binds to mu opioid receptors and diminishes the effects of opioid receptor agonists.
Topics: Analgesics, Opioid; Animals; Binding, Competitive; Brain; Dopamine; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Guinea Pigs; In Vitro Techniques; Lobeline; Mecamylamine; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Nicotine; Oocytes; Radioligand Assay; Receptors, Opioid; Receptors, Opioid, mu; Xenopus laevis | 2007 |
Absence of conditioned place preference or reinstatement with bivalent ligands containing mu-opioid receptor agonist and delta-opioid receptor antagonist pharmacophores.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Conditioning, Psychological; Ligands; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Narcotic Antagonists; Oxymorphone; Pain; Receptors, Opioid, delta; Receptors, Opioid, mu | 2007 |
Attenuation of vascular permeability by methylnaltrexone: role of mOP-R and S1P3 transactivation.
Topics: Analgesics, Opioid; Animals; Capillary Permeability; Cells, Cultured; Electrophysiology; Endothelial Cells; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Humans; Intracellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Protein Serine-Threonine Kinases; Quaternary Ammonium Compounds; Receptors, Lysosphingolipid; Receptors, Opioid, mu; rho-Associated Kinases; rhoA GTP-Binding Protein; RNA, Small Interfering; Thrombin; Transcriptional Activation | 2007 |
Time-dependent decreases in apparent pA2 values for naltrexone studied in combination with morphine in rhesus monkeys.
Topics: Animals; Discrimination, Psychological; Dose-Response Relationship, Drug; Female; Macaca mulatta; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Receptors, Opioid, mu; Time Factors | 2007 |
The opioid antagonist, beta-funaltrexamine, inhibits chemokine expression in human astroglial cells.
Topics: Analysis of Variance; Astrocytes; Astrocytoma; Cell Line, Tumor; Cell Survival; Chemokine CXCL10; Chemokines; Chemokines, CXC; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Activation; Enzyme-Linked Immunosorbent Assay; Fentanyl; Humans; Morphine; Naltrexone; Narcotic Antagonists; Narcotics | 2007 |
Sexually dimorphic recruitment of spinal opioid analgesic pathways by the spinal application of morphine.
Topics: Animals; Animals, Newborn; Antibodies; Dose-Response Relationship, Drug; Dynorphins; Female; Injections, Spinal; Male; Morphine; Naltrexone; Narcotic Antagonists; Neural Pathways; Orchiectomy; Ovariectomy; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sex Factors; Spinal Cord; Sufentanil; Virilism | 2007 |
Augmentation of spinal morphine analgesia and inhibition of tolerance by low doses of mu- and delta-opioid receptor antagonists.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Injections, Spinal; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Peptide Fragments; Peptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Somatostatin | 2007 |
Electron density analyses of opioids: a comparative study.
Topics: Analgesics, Opioid; Codeine; Cold Temperature; Dextromethorphan; Diprenorphine; Electrons; Models, Molecular; Morphine; Naltrexone; X-Ray Diffraction | 2007 |
Maternal separation alters ICSS responding in adult male and female rats, but morphine and naltrexone have little affect on that behavior.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Female; Humans; Male; Maternal Deprivation; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Long-Evans; Self Stimulation; Sex Factors | 2007 |
Effects of loperamide on mechanical allodynia induced by herpes simplex virus type-1 in mice.
Topics: Analgesics, Opioid; Animals; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Drug Tolerance; Female; Foot; Herpes Simplex; Herpesvirus 1, Human; Injections; Injections, Subcutaneous; Loperamide; Mice; Mice, Inbred C57BL; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Physical Stimulation | 2007 |
A tarantula peptide against pain via ASIC1a channels and opioid mechanisms.
Topics: Acid Sensing Ion Channels; Analgesics; Animals; Area Under Curve; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Enkephalins; Membrane Proteins; Mice; Mice, Knockout; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Nerve Tissue Proteins; Neurons; Pain; Pain Measurement; Peptides; Protein Precursors; Reaction Time; Sodium Channels; Spider Venoms; Spinal Cord; Time Factors | 2007 |
Increase in diazepam binding inhibitor expression by sustained morphine exposure is mediated via mu-opioid receptors in primary cultures of mouse cerebral cortical neurons.
Topics: Analysis of Variance; Animals; Cells, Cultured; Cerebral Cortex; Diazepam Binding Inhibitor; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; Enzyme Inhibitors; Gene Expression Regulation; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Neurons; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors | 2007 |
Morphine inhibits intrahepatic interferon- alpha expression and enhances complete hepatitis C virus replication.
Topics: Cells, Cultured; Dose-Response Relationship, Drug; Down-Regulation; Gene Expression Regulation; Hepacivirus; Hepatocytes; Humans; Interferon Regulatory Factors; Interferon-alpha; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Virus Replication | 2007 |
Naloxone rapidly evokes endogenous kappa opioid receptor-mediated hyperalgesia in naïve mice pretreated briefly with GM1 ganglioside or in chronic morphine-dependent mice.
Topics: Analgesics, Opioid; Animals; Chronic Disease; Dipeptides; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Synergism; G(M1) Ganglioside; Hyperalgesia; Male; Mice; Morphine; Morphine Dependence; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Opioid Peptides; Receptors, Opioid, kappa; Substance Withdrawal Syndrome | 2007 |
Mu-opioid receptor up-regulation and functional supersensitivity are independent of antagonist efficacy.
Topics: Animals; Dose-Response Relationship, Drug; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu; Substance Withdrawal Syndrome; Up-Regulation | 2007 |
Involvement of kappa opioid receptors in formalin-induced inhibition of analgesic tolerance to morphine in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Chronic Disease; Drug Tolerance; Formaldehyde; Male; Mice; Morphine; Naltrexone; Oligonucleotides, Antisense; Pain; Pain Measurement; Pain Threshold; Receptors, Opioid, delta; Receptors, Opioid, kappa; Tail | 2007 |
Intramuscular administration of morphine reduces mustard-oil-induced craniofacial-muscle pain behavior in lightly anesthetized rats.
Topics: Analgesics; Anesthesia, General; Animals; Inflammation; Injections; Injections, Intramuscular; Male; Masseter Muscle; Morphine; Mustard Plant; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Pain; Plant Oils; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Single-Blind Method; Somatostatin | 2008 |
Comparison of naltrexone, 6alpha-naltrexol, and 6beta-naltrexol in morphine-dependent and in nondependent rhesus monkeys.
Topics: Animals; Appetitive Behavior; Discrimination Learning; Dose-Response Relationship, Drug; Drug Inverse Agonism; Female; Macaca mulatta; Male; Morphine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu | 2008 |
Use of preproenkephalin knockout mice and selective inhibitors of enkephalinases to investigate the role of enkephalins in various behaviours.
Topics: Analysis of Variance; Animals; Behavior, Animal; CD13 Antigens; Disulfides; Dose-Response Relationship, Drug; Enkephalins; Enzyme Inhibitors; Injections, Intravenous; Mice; Mice, Inbred DBA; Mice, Knockout; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Neprilysin; Phenylalanine; Protein Precursors; Swimming | 2008 |
Isobolographic analysis of multimodal analgesia in an animal model of visceral acute pain.
Topics: Acetaminophen; Acute Disease; Adrenergic alpha-Antagonists; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Atropine; Behavior, Animal; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Ketoprofen; Male; Mice; Morphine; Muscarinic Antagonists; Naltrexone; Narcotic Antagonists; Pain; Prazosin | 2008 |
Opioid receptors are involved in the sedative and antinociceptive effects of hesperidin as well as in its potentiation with benzodiazepines.
Topics: Acetic Acid; Alprazolam; Analgesics; Animals; Behavior, Animal; Benzodiazepines; Dose-Response Relationship, Drug; Drug Synergism; Flunitrazepam; Hesperidin; Hypnotics and Sedatives; Injections, Intraperitoneal; Male; Mice; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Receptors, Opioid | 2008 |
Intrathecal antinociceptive interaction between the NMDA antagonist ketamine and the opioids, morphine and biphalin.
Topics: Analgesics; Analgesics, Non-Narcotic; Animals; Drug Synergism; Drug Therapy, Combination; Drug Tolerance; Enkephalins; Excitatory Amino Acid Antagonists; Hot Temperature; Injections, Spinal; Ketamine; Male; Morphine; Naltrexone; Narcotics; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Tail | 2008 |
Morphine postconditioning protects against reperfusion injury in the isolated rat hearts.
Topics: Analgesics, Opioid; Animals; Anti-Arrhythmia Agents; Cardiotonic Agents; Decanoic Acids; Dose-Response Relationship, Drug; Hydroxy Acids; In Vitro Techniques; Ischemic Preconditioning, Myocardial; Male; Morphine; Myocardial Infarction; Naloxone; Naltrexone; Narcotic Antagonists; Potassium Channels; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2008 |
Seizure susceptibility alteration following reversible cholestasis in mice: Modulation by opioids and nitric oxide.
Topics: 1-Naphthylisothiocyanate; Alkaline Phosphatase; Animals; Bilirubin; Biomarkers; Cholestasis; Corn Oil; Disease Models, Animal; Disease Susceptibility; Dose-Response Relationship, Drug; Infusions, Intravenous; Intubation, Gastrointestinal; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pentylenetetrazole; Receptors, Opioid; Seizures; Time Factors | 2008 |
Blockade of micro-opioid receptors in the medial thalamus inhibits acquisition, but not expression, of morphine-induced conditioned place preference.
Topics: Animals; Behavior, Animal; Conditioning, Operant; Drug Administration Routes; Drug Interactions; Male; Microinjections; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Thalamus | 2008 |
Comparison of the opioid receptor antagonist properties of naltrexone and 6 beta-naltrexol in morphine-naïve and morphine-dependent mice.
Topics: Animals; Binding, Competitive; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred ICR; Morphinans; Morphine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Narcotics; Pain Measurement; Pyrroles; Receptors, Opioid, mu; Substance Withdrawal Syndrome | 2008 |
The comparison of effects of processed Aconiti tuber, U50488H and MK-801 on the antinociceptive tolerance to morphine.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Aconitum; Analgesics, Opioid; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Tolerance; Male; Mice; Morphine; Naltrexone; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa | 2008 |
Dopamine-independent psychostimulant activity of a delta-agonist.
Topics: Animals; Benzamides; Brain; Central Nervous System Stimulants; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Synergism; Haloperidol; Male; Mice; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Piperazines; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Opioid, delta | 2008 |
Overriding the blockade of antinociceptive actions of opioids in rats treated with extended-release naltrexone.
Topics: Alcoholism; Analgesics, Opioid; Animals; Delayed-Action Preparations; Drug Interactions; Fentanyl; Humans; Hydrocodone; Male; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Plethysmography, Whole Body; Rats; Rats, Sprague-Dawley; Respiration | 2008 |
The mu opioid receptor mediates morphine-induced tumor necrosis factor and interleukin-6 inhibition in toll-like receptor 2-stimulated monocytes.
Topics: Cell Separation; Cells, Cultured; Cytokines; Humans; Inflammation; Interleukin-6; Monocytes; Morphine; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu; Toll-Like Receptor 2; Tumor Necrosis Factor-alpha | 2008 |
Sex differences in hyperalgesia during morphine infusion: effect of gonadectomy and estrogen treatment.
Topics: Analgesics, Opioid; Animals; Data Interpretation, Statistical; Dizocilpine Maleate; Dose-Response Relationship, Drug; Estrogens; Excitatory Amino Acid Antagonists; Female; Hyperalgesia; Infusions, Intravenous; Isoquinolines; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Orchiectomy; Ovariectomy; Pain Measurement; Receptors, N-Methyl-D-Aspartate; Sex Characteristics | 2008 |
Morphine-nicotine interaction in conditioned place preference in mice after chronic nicotine exposure.
Topics: Analgesics, Opioid; Animals; Autoradiography; Conditioning, Operant; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Nicotine; Nicotinic Agonists; Receptors, Opioid, mu | 2008 |
Interactions between Delta(9)-tetrahydrocannabinol and mu opioid receptor agonists in rhesus monkeys: discrimination and antinociception.
Topics: Analgesics; Analgesics, Opioid; Animals; Data Interpretation, Statistical; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Female; Heroin; Hot Temperature; Hypnotics and Sedatives; Macaca mulatta; Male; Midazolam; Morphine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Pain Measurement; Receptors, Opioid, mu; Substance Withdrawal Syndrome | 2008 |
Mu-opioid receptor in the nucleus submedius: involvement in opioid-induced inhibition of mirror-image allodynia in a rat model of neuropathic pain.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Enkephalin, Leucine-2-Alanine; Hyperalgesia; Ligation; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Neuralgia; Oligopeptides; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Spinal Nerves; Thalamic Nuclei | 2008 |
In vivo characterization of (-)(-)MCL-144 and (+)(-)MCL-193: isomeric, bivalent ligands with mu/kappa agonist properties.
Topics: Alkanes; Analgesics; Animals; Brain; CHO Cells; Cricetinae; Cricetulus; Fumarates; Guanosine 5'-O-(3-Thiotriphosphate); Half-Life; Male; Morphinans; Morphine; Naltrexone; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stereoisomerism | 2008 |
Morphine suppresses intracellular interferon-alpha expression in neuronal cells.
Topics: Blotting, Western; Cell Line; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique; Gene Expression; Humans; Interferon-gamma; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Neurons; Promoter Regions, Genetic; Receptors, Opioid, mu; Reverse Transcriptase Polymerase Chain Reaction; STAT1 Transcription Factor; Transfection | 2008 |
Inhibition of the development of morphine tolerance by a potent dual mu-delta-opioid antagonist, H-Dmt-Tic-Lys-NH-CH2-Ph.
Topics: Analgesics, Opioid; Animals; Area Under Curve; Dose-Response Relationship, Drug; Drug Tolerance; Injections, Intraventricular; Injections, Subcutaneous; Ligands; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Oligopeptides; Reaction Time; Receptors, Opioid, delta; Receptors, Opioid, mu; Somatostatin | 2008 |
Differential responses to morphine-induced analgesia in the tail-flick test.
Topics: Analgesia; Analgesics, Opioid; Analysis of Variance; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Gene Expression Regulation; Male; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Pain Measurement; Periaqueductal Gray; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Time Factors | 2008 |
Augmentation of morphine-induced sensitization but reduction in morphine tolerance and reward in delta-opioid receptor knockout mice.
Topics: Animals; Conditioning, Psychological; Drug Tolerance; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Reward; Spatial Behavior | 2009 |
Crucial role of peripheral kappa-opioid receptors in a model of periodontal disease in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Chronic Periodontitis; Disease Models, Animal; Male; Morphine; Naltrexone; Narcotic Antagonists; Peripheral Nervous System; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa | 2008 |
Hyaluronan-tethered opioid depots: synthetic strategies and release kinetics in vitro and in vivo.
Topics: Analgesics, Opioid; Animals; Buffers; Drug Delivery Systems; Esterases; Esters; Half-Life; Hyaluronic Acid; Hydrolysis; Kinetics; Male; Mass Spectrometry; Morphine; Naltrexone; Rats; Rats, Sprague-Dawley | 2008 |
Antagonist-precipitated and discontinuation-induced withdrawal in morphine-dependent rhesus monkeys.
Topics: Animals; Behavior, Animal; Body Temperature; Circadian Rhythm; Conditioning, Operant; Discrimination Learning; Drug Administration Schedule; Female; Heart Rate; Humans; Injections, Subcutaneous; Macaca mulatta; Morphine; Morphine Dependence; Motor Activity; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Sodium Chloride; Stereotyped Behavior; Substance Withdrawal Syndrome; Time Factors | 2008 |
Narp regulates long-term aversive effects of morphine withdrawal.
Topics: Amygdala; Animals; Avoidance Learning; Behavior, Animal; C-Reactive Protein; Conditioning, Operant; Disease Models, Animal; Extinction, Psychological; Female; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Nerve Tissue Proteins; Retention, Psychology; Septal Nuclei; Substance Withdrawal Syndrome | 2008 |
Morphine attenuates the expression of sensitization to ethanol, but opioid antagonists do not.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Autoradiography; Behavior, Animal; Brain; Central Nervous System Depressants; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Ethanol; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Protein Binding; Rats; Rats, Wistar; Tritium | 2008 |
Differential effect of morphine and morphine-6-glucuronide on the control of breathing in the anesthetized cat.
Topics: Analgesics, Opioid; Anesthesia; Animals; Blood-Brain Barrier; Carbon Dioxide; Cats; Female; Male; Morphine; Morphine Derivatives; Naltrexone; Respiration | 2008 |
Antinociceptive action of 4-methyl-5-trifluoromethyl-5-hydroxy-4, 5-dihydro-1H-pyrazole methyl ester in models of inflammatory pain in mice.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Dipyrone; Freund's Adjuvant; Indomethacin; Inflammation; Male; Mice; Morphine; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Pain, Postoperative; Postural Balance; Pyrazoles; Stomach Ulcer | 2008 |
M5 muscarinic receptor knockout mice show reduced morphine-induced locomotion but increased locomotion after cholinergic antagonism in the ventral tegmental area.
Topics: Animals; Atropine; Cholinergic Antagonists; Crosses, Genetic; Homozygote; Locomotion; Mecamylamine; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Knockout; Morphine; Motor Activity; Naltrexone; Receptor, Muscarinic M5; Ventral Tegmental Area | 2009 |
Strain-specific differences in modulatory effects of morphine on peritoneal inflammation in mice.
Topics: Animals; Dose-Response Relationship, Drug; Leukocytes; Male; Mice; Mice, Inbred Strains; Morphine; Naltrexone; Peritonitis; Zymosan | 2005 |
Open elevated plus maze-induced antinociception in rats: a non-opioid type of pain inhibition?
Topics: Adaptation, Physiological; Adrenalectomy; Analgesics, Opioid; Analysis of Variance; Animals; Drug Tolerance; Habituation, Psychophysiologic; Inhibition, Psychological; Male; Maze Learning; Morphine; Naltrexone; Narcotic Antagonists; Pain; Pain Threshold; Rats; Stress, Psychological | 2009 |
Tolerance to the anticonvulsant effect of morphine in mice: blockage by ultra-low dose naltrexone.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Tolerance; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Pentylenetetrazole; Seizures | 2009 |
FDA panel debates merits of next-generation opioid formulations.
Topics: Analgesics, Opioid; Delayed-Action Preparations; Drug Approval; Humans; Morphine; Naltrexone; Oxycodone; United States; United States Food and Drug Administration | 2009 |
Validation of a novel social investigation task that may dissociate social motivation from exploratory activity.
Topics: Amphetamine; Animals; Circadian Rhythm; Exploratory Behavior; Female; Haloperidol; Lighting; Male; Morphine; Motivation; Naltrexone; Psychological Tests; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Social Behavior | 2009 |
Evidence for the involvement of the opioid system in the antidepressant-like effect of folic acid in the mouse forced swimming test.
Topics: Analgesics, Opioid; Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Disease Models, Animal; Dizocilpine Maleate; Drug Combinations; Excitatory Amino Acid Antagonists; Exploratory Behavior; Folic Acid; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Swimming | 2009 |
The analgesic actions of centrally administered celecoxib are mediated by endogenous opioids.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Celecoxib; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Administration Schedule; Drug Interactions; Enzyme Inhibitors; Immunologic Factors; Inflammation; Injections, Intraventricular; Leucine; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Pain Threshold; Pyrazoles; Rats; Reaction Time; Sulfonamides; Time Factors | 2009 |
Neutral antagonist activity of naltrexone and 6beta-naltrexol in naïve and opioid-dependent C6 cells expressing a mu-opioid receptor.
Topics: Adenylyl Cyclases; Animals; Binding, Competitive; Cell Line; Cell Line, Tumor; Cyclic AMP; Drug Inverse Agonism; Drug Partial Agonism; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Humans; Morphine; Naloxone; Naltrexone; Peptide Fragments; Piperidines; Radioligand Assay; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Somatostatin | 2009 |
Inhibitory effect of low-dose pentazocine on the development of antinociceptive tolerance to morphine.
Topics: Analgesics, Opioid; Animals; Cinnamates; Dose-Response Relationship, Drug; Drug Tolerance; Male; Mice; Mice, Inbred ICR; Morphine; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Pain Measurement; Pentazocine; Pressure; Receptors, Opioid, kappa | 2009 |
Mu-opioid receptor redistribution in the locus coeruleus upon precipitation of withdrawal in opiate-dependent rats.
Topics: Analgesics, Opioid; Animals; Fluorescent Antibody Technique; Immunoenzyme Techniques; Locus Coeruleus; Male; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Substance Withdrawal Syndrome | 2009 |
Involvement of exon 11-associated variants of the mu opioid receptor MOR-1 in heroin, but not morphine, actions.
Topics: Alternative Splicing; Analgesia; Animals; Exons; Gastrointestinal Transit; Gene Targeting; Heroin; Heterozygote; Mice; Mice, Knockout; Morphine; Mutation; Naloxone; Naltrexone; Receptors, Opioid, mu | 2009 |
Scratching behavior and Fos expression in superficial dorsal horn elicited by protease-activated receptor agonists and other itch mediators in mice.
Topics: Animals; Behavior, Animal; Capsaicin; Histamine; Injections, Intradermal; Mice; Morphine; Naltrexone; Oligopeptides; Posterior Horn Cells; Proto-Oncogene Proteins c-fos; Pruritus; Receptor, PAR-2; Receptors, Opioid, mu; Receptors, Proteinase-Activated; Serotonin; Spinal Cord; Tachyphylaxis | 2009 |
Shadows across mu-Star? Constitutively active mu-opioid receptors revisited.
Topics: Adenylyl Cyclases; Animals; Binding, Competitive; Cell Line; Cell Line, Tumor; Drug Inverse Agonism; Drug Partial Agonism; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Humans; Morphine; Naltrexone; Radioligand Assay; Rats; Receptors, Opioid, mu | 2009 |
Route of administration influences substitution patterns in rats trained to discriminate methadone vs. vehicle.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Choice Behavior; Conditioning, Operant; Discrimination, Psychological; Heroin; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Methadone; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Pharmaceutical Vehicles; Rats; Rats, Sprague-Dawley; Stereoisomerism | 2009 |
Naltrexone fails to increase pain affect in response to inflammatory pain in a novel escape/avoidance paradigm.
Topics: Animals; Avoidance Learning; Carrageenan; Dose-Response Relationship, Drug; Drug Interactions; Inflammation; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Pain Threshold; Random Allocation; Rats; Rats, Sprague-Dawley | 2009 |
The unconditioned fear produced by morphine withdrawal is regulated by mu- and kappa-opioid receptors in the midbrain tectum.
Topics: Analgesics, Opioid; Animals; Catheterization; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Escape Reaction; Fear; Freezing Reaction, Cataleptic; Male; Microinjections; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid, kappa; Receptors, Opioid, mu; Substance Withdrawal Syndrome; Tectum Mesencephali | 2009 |
Withania somnifera prevents morphine withdrawal-induced decrease in spine density in nucleus accumbens shell of rats: a confocal laser scanning microscopy study.
Topics: Analysis of Variance; Animals; Behavior, Animal; Chromatography, High Pressure Liquid; Dendritic Spines; Disease Models, Animal; Male; Microscopy, Confocal; Morphine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Neurons; Nucleus Accumbens; Phytotherapy; Plant Extracts; Rats; Rats, Sprague-Dawley; Silver Staining; Substance Withdrawal Syndrome; Time Factors; Withania | 2009 |
The antinociceptive properties of reboxetine in acute pain.
Topics: Adrenergic Antagonists; Analgesics; Animals; Antidepressive Agents; Clonidine; Disease Models, Animal; Drug Interactions; Male; Mice; Mice, Inbred ICR; Morphine; Morpholines; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Reboxetine; Receptors, Opioid, mu | 2009 |
Lack of effect of naltrindole on the spinal synergism of morphine and non-steroidal anti-inflammatory drugs (NSAIDS).
Topics: Analgesics, Opioid; Animals; Cyclooxygenase Inhibitors; Drug Synergism; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Morphine; Naltrexone; Pain; Receptors, Opioid, delta; Spinal Cord | 2009 |
Regional Fos expression induced by morphine withdrawal in the 7-day-old rat.
Topics: Analysis of Variance; Animals; Animals, Newborn; Cell Count; Female; Immunohistochemistry; Locus Coeruleus; Male; Morphine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Narcotics; Nucleus Accumbens; Periaqueductal Gray; Pregnancy; Proto-Oncogene Proteins c-fos; Rats; Rats, Long-Evans; Spinal Cord; Substance Withdrawal Syndrome | 2009 |
Possible involvement of the hypothalamic pro-opiomelanocortin gene and beta-endorphin expression on acute morphine withdrawal development.
Topics: Animals; Arcuate Nucleus of Hypothalamus; Baclofen; beta-Endorphin; Dose-Response Relationship, Drug; GABA Agonists; Gene Expression; Hypothalamus; Male; Mice; Mice, Inbred ICR; Morphine; Muscimol; Naltrexone; Narcotic Antagonists; Narcotics; Pro-Opiomelanocortin; Substance Withdrawal Syndrome | 2009 |
Evaluation of the tocolytic effect of morphine in a mouse model of lipopolysaccharide-induced preterm delivery: the role of nitric oxide.
Topics: Animals; Female; Lipopolysaccharides; Male; Mice; Morphine; Naltrexone; NG-Nitroarginine Methyl Ester; Nitric Oxide; Obstetric Labor, Premature; Placenta; Pregnancy; Tocolytic Agents | 2009 |
Novel approach to demonstrate high efficacy of mu opioids in the rat vas deferens: a simple model of predictive value.
Topics: Analgesics, Opioid; Animals; Brain; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Male; Mice; Mice, Inbred Strains; Models, Biological; Morphine; Morphine Derivatives; Naltrexone; Oxymorphone; Pain; Rats; Rats, Wistar; Receptors, Opioid, mu; Vas Deferens | 2010 |
Characteristics and comparative severity of respiratory response to toxic doses of fentanyl, methadone, morphine, and buprenorphine in rats.
Topics: Animals; Blood Gas Analysis; Buprenorphine; Catheterization; Fentanyl; Lactic Acid; Male; Methadone; Morphine; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Narcotics; Plethysmography, Whole Body; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Respiratory Insufficiency; Respiratory Mechanics | 2009 |
Acute methadone treatment reduces myocardial infarct size via the delta-opioid receptor in rats during reperfusion.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Male; Methadone; Morphine; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Time Factors | 2009 |
Long-lasting antinociceptive spinal effects in primates of the novel nociceptin/orphanin FQ receptor agonist UFP-112.
Topics: Analgesics; Animals; Benzimidazoles; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hyperalgesia; Injections, Spinal; Macaca mulatta; Male; Morphine; Naltrexone; Nociceptin; Opioid Peptides; Pain Measurement; Pain Threshold; Piperidines | 2010 |
Sex-specific mediation of opioid-induced hyperalgesia by the melanocortin-1 receptor.
Topics: Analgesics, Opioid; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Female; Hyperalgesia; Infusions, Intravenous; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphine; Naltrexone; Narcotic Antagonists; Receptor, Melanocortin, Type 1; Receptors, N-Methyl-D-Aspartate; Sex Characteristics | 2010 |
PRODUCT: Embeda 20mg/0.8mg.
Topics: Analgesics, Opioid; Contraindications; Delayed-Action Preparations; Humans; Morphine; Naltrexone; Narcotic Antagonists; Osteoarthritis; Pain | 2009 |
Mu-opioid receptors are not necessary for nortriptyline treatment of neuropathic allodynia.
Topics: Adrenergic Uptake Inhibitors; Analysis of Variance; Animals; Male; Mice; Mice, Knockout; Morphine; Naltrexone; Narcotic Antagonists; Neuralgia; Nortriptyline; Pain Measurement; Receptors, Opioid, mu | 2010 |
Effects of kappa opioids in an assay of pain-depressed intracranial self-stimulation in rats.
Topics: Analgesics; Analgesics, Opioid; Animals; Benzeneacetamides; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Lactic Acid; Male; Medial Forebrain Bundle; Morphine; Naltrexone; Pain; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reinforcement, Psychology; Self Stimulation | 2010 |
In vivo characterization of the opioid antagonist nalmefene in mice.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Inhibitory Concentration 50; Male; Mice; Mice, Inbred ICR; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Pain; Substance Withdrawal Syndrome; Time Factors | 2010 |
Severe opioid withdrawal due to misuse of new combined morphine and naltrexone product (Embeda).
Topics: Adult; Drug Combinations; Female; Humans; Morphine; Naltrexone; Patient Education as Topic; Substance Withdrawal Syndrome | 2010 |
The involvement of micro-opioid receptors in the central nervous system in the worsening of allergic airway inflammation by psychological stress in mice.
Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Central Nervous System; Cytokines; Disease Models, Animal; Female; Humans; Immunoglobulin E; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphine; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu; Stress, Psychological; Th2 Cells | 2010 |
Evidence of central and peripheral sensitization in a rat model of narcotic bowel-like syndrome.
Topics: Abdominal Pain; Animals; CD11b Antigen; Chymases; Colon; Delayed-Action Preparations; Disease Models, Animal; Gastrointestinal Transit; Hyperalgesia; Immunohistochemistry; Intestinal Mucosa; Male; Mast Cells; Microglia; Minocycline; Morphine; Naltrexone; Narcotic Antagonists; p38 Mitogen-Activated Protein Kinases; Pain Measurement; Pain Threshold; Pressure; Rats; Rats, Wistar; Spinal Cord; Syndrome; Thioxanthenes; Time Factors; Ubiquitin Thiolesterase; Xanthones | 2010 |
Pretreatment time with norbinaltorphimine.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Injections, Intraventricular; Injections, Spinal; Ischemic Preconditioning, Myocardial; Morphine; Naltrexone; Narcotic Antagonists; Rats; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2010 |
Ultra-low dose naltrexone attenuates chronic morphine-induced gliosis in rats.
Topics: Animals; Drug Tolerance; Gliosis; Imaging, Three-Dimensional; Immunohistochemistry; Male; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Spinal Cord | 2010 |
New drug formulation treats chronic pain.
Topics: Analgesics, Opioid; Chemistry, Pharmaceutical; Chronic Disease; Drug Combinations; Drug Therapy; Humans; Morphine; Naltrexone; Pain; Receptors, Opioid; Severity of Illness Index | 2010 |
Investigation of Beckett-Casy model 2: synthesis of novel 15-16 nornaltrexone derivatives and their pharmacology.
Topics: Electrons; Ethylenes; Hydrogen Bonding; Morphine; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Structure-Activity Relationship | 2010 |
Disruption of morphine-conditioned place preference by a delta2-opioid receptor antagonist: study of mu-opioid and delta-opioid receptor expression at the synapse.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Conditioning, Classical; Male; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Subcellular Fractions; Synapses | 2010 |
Spontaneous itch in the absence of hyperalgesia in a mouse hindpaw dry skin model.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Hindlimb; Hyperalgesia; Male; Mice; Morphine; Naltrexone; Pain Measurement; Pruritus; Skin | 2010 |
Tolerance to the antinociceptive effect of morphine in the absence of short-term presynaptic desensitization in rat periaqueductal gray neurons.
Topics: Analgesics; Animals; Drug Tolerance; Electrophysiological Phenomena; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Inhibitory Postsynaptic Potentials; Male; Morphine; Naltrexone; Neurons; Pain Measurement; Patch-Clamp Techniques; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid, mu; Signal Transduction | 2010 |
Activation of phosphatidylinositol 3-kinase/Akt-mammalian target of Rapamycin signaling pathway in the hippocampus is essential for the acquisition of morphine-induced place preference in rats.
Topics: Animals; Chromones; Conditioning, Operant; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glial Fibrillary Acidic Protein; Hippocampus; Male; Morphine; Morpholines; Naltrexone; Narcotic Antagonists; Narcotics; Phosphatidylinositol 3-Kinases; Phosphopyruvate Hydratase; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction; Sirolimus; Statistics as Topic | 2010 |
Dorsal hippocampal opioidergic system modulates anxiety-like behaviors in adult male Wistar rats.
Topics: Analgesics, Opioid; Animals; Anxiety; CA1 Region, Hippocampal; Disease Models, Animal; Enkephalin, D-Penicillamine (2,5)-; Male; Maze Learning; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu | 2010 |
Differential itch- and pain-related behavioral responses and µ-opoid modulation in mice.
Topics: Analgesics, Opioid; Animals; Antigens, Plant; Behavior, Animal; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Histamine; Injections, Intradermal; Irritants; Male; Mice; Mice, Inbred ICR; Morphine; Motor Activity; Mucuna; Naltrexone; Narcotic Antagonists; Pain; Pruritus; Receptor, PAR-2; Receptors, Opioid, mu; Receptors, Thrombin; Time Factors | 2010 |
The effect of morphine on orthodontic tooth movement in rats.
Topics: Analgesics, Opioid; Animals; Bone Resorption; Dental Alloys; Male; Maxilla; Molar; Morphine; Naltrexone; Narcotic Antagonists; Nickel; Orthodontic Wires; Osteoclasts; Random Allocation; Rats; Rats, Wistar; Root Resorption; Titanium; Tooth Apex; Tooth Cervix; Tooth Movement Techniques; Tooth Root | 2010 |
Morphine postconditioning attenuates ICAM-1 expression on endothelial cells.
Topics: Animals; Benzophenanthridines; Endothelial Cells; Endothelium, Vascular; Humans; Intercellular Adhesion Molecule-1; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Protein Isoforms; Protein Kinase C; Receptors, Opioid; Reperfusion Injury; Signal Transduction; Umbilical Veins | 2011 |
Morphine sensitization in the pentylenetetrazole-induced clonic seizure threshold in mice: role of nitric oxide and μ receptors.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pentylenetetrazole; Receptors, Opioid, mu; Seizures | 2011 |
Ketanserin potentiates morphine-induced antinociception mediated by kappa-receptor activation.
Topics: Adrenergic alpha-1 Receptor Antagonists; Analgesics; Animals; Dose-Response Relationship, Drug; Drug Synergism; Ketanserin; Male; Mice; Mice, Inbred Strains; Morphine; Naltrexone; Pain; Pain Measurement; Pain Threshold; Prazosin; Pyrrolidines; Receptors, Adrenergic, alpha-1; Receptors, Opioid, kappa; Receptors, Serotonin, 5-HT2; Serotonin Antagonists | 2011 |
Sustained-release morphine sulfate with sequestered naltrexone for moderate to severe pain: a new opioid analgesic formulation and beyond.
Topics: Analgesics, Opioid; Delayed-Action Preparations; Dosage Forms; Drug Combinations; Humans; Morphine; Naltrexone; Opioid-Related Disorders; Pain | 2011 |
Dissociable effects of ultralow-dose naltrexone on tolerance to the antinociceptive and cataleptic effects of morphine.
Topics: Analgesics, Opioid; Animals; Catalepsy; Dose-Response Relationship, Drug; Drug Tolerance; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain; Rats; Rats, Long-Evans; Time Factors | 2011 |
Involvement of neuropeptide FF receptors in neuroadaptive responses to acute and chronic opiate treatments.
Topics: Adamantane; Analgesics, Opioid; Animals; Behavior, Animal; Conditioning, Classical; Dipeptides; Drug Tolerance; Fentanyl; Hot Temperature; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Pain; Receptors, Neuropeptide; Substance Withdrawal Syndrome | 2012 |
Drug discrimination in pigeons trained to discriminate among morphine, U50488, a combination of these drugs, and saline.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Butorphanol; Columbidae; Discrimination Learning; Dose-Response Relationship, Drug; Ethylketocyclazocine; Male; Morphine; Naltrexone; Narcotic Antagonists; Pentazocine; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reinforcement Schedule; Sodium Chloride | 2011 |
Neuroprotective potential of biphalin, multireceptor opioid peptide, against excitotoxic injury in hippocampal organotypic culture.
Topics: Animals; Enkephalins; Excitatory Amino Acid Agents; Hippocampus; Morphine; N-Methylaspartate; Naltrexone; Narcotic Antagonists; Neuroprotective Agents; Organ Culture Techniques; Rats; Rats, Wistar; Receptors, Opioid, delta | 2011 |
Opioidergic modulation of ethanol self-administration in the ventral pallidum.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Alcohol Drinking; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Globus Pallidus; Male; Microinjections; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Self Administration; Somatostatin | 2012 |
Potentiation of brain stimulation reward by morphine: effects of neurokinin-1 receptor antagonism.
Topics: Analgesics, Opioid; Animals; Brain; Dose-Response Relationship, Drug; Electric Stimulation; Male; Mice; Mice, Inbred C57BL; Morphine; Naltrexone; Narcotic Antagonists; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Reinforcement, Psychology; Reward; Substance P | 2012 |
Adverse events in the removal of naltrexone implants.
Topics: Adolescent; Adult; Analgesics, Opioid; Anesthesia Recovery Period; Anesthesia, Spinal; Anesthetics, General; Anesthetics, Local; Device Removal; Female; Humans; Incidence; Infections; Infusion Pumps, Implantable; Length of Stay; Male; Middle Aged; Morphine; Naltrexone; Narcotic Antagonists; Pain, Postoperative; Postoperative Complications; Retrospective Studies; Young Adult | 2011 |
Reversal of morphine-induced urinary retention after methylnaltrexone.
Topics: Analgesics, Opioid; Humans; Infant, Newborn; Male; Morphine; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Ultrasonography; Urinary Retention | 2012 |
Structural basis for μ-opioid receptor binding and activation.
Topics: Amino Acid Substitution; Animals; Binding Sites; Binding, Competitive; Cattle; Cyclic AMP; Databases, Factual; Decapodiformes; Diprenorphine; Dose-Response Relationship, Drug; HEK293 Cells; Humans; Molecular Dynamics Simulation; Morphine; Mutagenesis, Site-Directed; Naltrexone; Protein Binding; Radioligand Assay; Receptors, Opioid, mu; Small Molecule Libraries | 2011 |
YFa and analogs: investigation of opioid receptors in smooth muscle contraction.
Topics: Acetylcholine; Analgesics, Opioid; Animals; Cholinergic Agonists; Dynorphins; Enkephalin, Methionine; Guinea Pigs; Ileum; Male; Mice; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists; Neurotransmitter Agents; Oligopeptides; Receptors, Opioid; Vas Deferens | 2011 |
Agonist-selective effects of opioid receptor ligands on cytosolic calcium concentration in rat striatal neurons.
Topics: Animals; beta-Endorphin; Buprenorphine; Calcium; Corpus Striatum; Cytosol; Fluorescent Dyes; Fura-2; Ligands; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Opioid | 2012 |
Mu opioid receptor activation modulates Toll like receptor 4 in murine macrophages.
Topics: Analgesics, Opioid; Animals; Cells, Cultured; Gene Expression; Immunosuppressive Agents; Macrophages, Peritoneal; Mice; Morphine; Naltrexone; Receptors, Opioid, mu; Toll-Like Receptor 4 | 2012 |
Opioid modulation of facial itch- and pain-related responses and grooming behavior in rats.
Topics: Analgesics, Opioid; Animals; Antipruritics; Disease Models, Animal; Face; Grooming; Injections, Intradermal; Male; Morphine; Mustard Plant; Naltrexone; Narcotic Antagonists; Pain; Plant Oils; Pruritus; Rats; Rats, Sprague-Dawley; Serotonin; Time Factors | 2012 |
The role of mu-opioid receptor signaling in the dorsolateral periaqueductal gray on conditional and unconditional responding to threatening and aversive stimuli.
Topics: Animals; Behavior, Animal; Conditioning, Psychological; Fear; Male; Morphine; Naltrexone; Narcotic Antagonists; Periaqueductal Gray; Rats; Rats, Long-Evans; Receptors, Opioid, mu; Signal Transduction | 2012 |
The rewarding action of acute cocaine is reduced in β-endorphin deficient but not in μ opioid receptor knockout mice.
Topics: Animals; Behavior, Animal; beta-Endorphin; Cocaine; Conditioning, Operant; Male; Mice; Mice, Knockout; Morphine; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu; Reward | 2012 |
Supraspinal antinociceptive effect of apelin-13 in a mouse visceral pain model.
Topics: Acetic Acid; Analgesics; Analgesics, Opioid; Animals; Drug Synergism; Injections, Intraperitoneal; Injections, Intraventricular; Injections, Spinal; Intercellular Signaling Peptides and Proteins; Male; Mice; Morphine; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Nociception; Visceral Pain | 2012 |
Differential development of antinociceptive tolerance to morphine and fentanyl is not linked to efficacy in the ventrolateral periaqueductal gray of the rat.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Fentanyl; Male; Microinjections; Morphine; Naltrexone; Narcotic Antagonists; Pain Measurement; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Reaction Time | 2012 |
Methylnaltrexone for opioid-induced constipation in a pediatric oncology patient.
Topics: Analgesics, Opioid; Brain Neoplasms; Child; Constipation; Female; Humans; Morphine; Naltrexone; Narcotic Antagonists; Neuroblastoma; Pain; Quaternary Ammonium Compounds | 2012 |
Characterization of 6α- and 6β-N-heterocyclic substituted naltrexamine derivatives as novel leads to development of mu opioid receptor selective antagonists.
Topics: Animals; Caco-2 Cells; CHO Cells; Cricetinae; Cricetulus; Drug Implants; Guanosine 5'-O-(3-Thiotriphosphate); Heterocyclic Compounds; Humans; Male; Membranes; Mice; Morphine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Receptors, Opioid, mu; Substance Withdrawal Syndrome; Thalamus | 2011 |
Antinociceptive properties of Micrurus lemniscatus venom.
Topics: Administration, Oral; Analgesics; Animals; Elapid Venoms; Elapidae; Male; Mice; Morphine; Naltrexone; Pain; Pain Measurement; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 2012 |
Role of µ-opioid receptor reserve and µ-agonist efficacy as determinants of the effects of µ-agonists on intracranial self-stimulation in rats.
Topics: Animals; Brain; Drug Tolerance; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Reinforcement Schedule; Self Stimulation | 2012 |
Pain-facilitating medullary neurons contribute to opioid-induced respiratory depression.
Topics: Analgesics, Opioid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Evoked Potentials; Male; Medulla Oblongata; Morphine; Naltrexone; Narcotic Antagonists; Neurons; Nociception; Nociceptive Pain; Rats; Rats, Sprague-Dawley; Respiratory Insufficiency | 2012 |
Morphine induces hyperalgesia without involvement of μ-opioid receptor or morphine-3-glucuronide.
Topics: Animals; Hyperalgesia; Male; Mice; Morphine; Morphine Derivatives; Naltrexone; Reaction Time; Receptors, Opioid, mu | 2012 |
Spinal cord stimulation reduces hypersensitivity through activation of opioid receptors in a frequency-dependent manner.
Topics: Analgesics, Opioid; Animals; Hyperalgesia; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Neuralgia; Pain Measurement; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Spinal Cord; Spinal Cord Stimulation | 2013 |
The implications of tamper-resistant formulations for opioid rotation.
Topics: Analgesics, Opioid; Chronic Pain; Delayed-Action Preparations; Drug Combinations; Drug Compounding; Drug Tolerance; Humans; Morphine; Naltrexone; Opioid-Related Disorders; Oxycodone; Oxymorphone; Patient Selection | 2012 |
Involvement of peripheral cannabinoid and opioid receptors in β-caryophyllene-induced antinociception.
Topics: Animals; Cannabinoids; Endorphins; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Nociception; Pain; Pain Measurement; Polycyclic Sesquiterpenes; Receptor, Cannabinoid, CB2; Sesquiterpenes | 2013 |
Antinociceptive effects of two deltorphins analogs in the tail-immersion test in rats.
Topics: Analgesics, Opioid; Animals; Drug Synergism; Drug Tolerance; Male; Morphine; Naltrexone; Narcotic Antagonists; Nociception; Oligopeptides; Pain Measurement; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa | 2013 |
A non-rewarding, non-aversive buprenorphine/naltrexone combination attenuates drug-primed reinstatement to cocaine and morphine in rats in a conditioned place preference paradigm.
Topics: Animals; Behavior, Animal; Buprenorphine; Cocaine; Conditioning, Psychological; Cues; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Therapy, Combination; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Sprague-Dawley; Reward | 2014 |
Maternally administered sustained-release naltrexone in rats affects offspring neurochemistry and behaviour in adulthood.
Topics: Animals; Behavior, Animal; Brain; Delayed-Action Preparations; Dynorphins; Enkephalins; Female; Gene Expression; Male; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Narcotics; Neostriatum; Pregnancy; Prenatal Exposure Delayed Effects; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Self Administration | 2012 |
Effects of methylnaltrexone on guinea pig gastrointestinal motility.
Topics: Animals; Gastrointestinal Motility; Gastrointestinal Tract; Guinea Pigs; Male; Morphine; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Receptors, Opioid, mu | 2013 |
Increased agonist affinity at the μ-opioid receptor induced by prolonged agonist exposure.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Arrestin; Cell Membrane; Cells, Cultured; Dose-Response Relationship, Drug; Embryo, Mammalian; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Fibroblasts; Gene Expression; Guanosine 5'-O-(3-Thiotriphosphate); HEK293 Cells; Humans; Ligands; Mice; Mice, Knockout; Morphine; Naltrexone; Narcotic Antagonists; Opioid Peptides; Organic Chemicals; Pertussis Toxin; Pharmacological Phenomena; Protein Binding; Protein Conformation; Radioligand Assay; Receptors, Opioid, mu; Substrate Specificity; Time Factors; Transfection; Tritium | 2013 |
Differential control of opioid antinociception to thermal stimuli in a knock-in mouse expressing regulator of G-protein signaling-insensitive Gαo protein.
Topics: Analgesics, Opioid; Animals; Brain; Diprenorphine; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Excitatory Amino Acid Antagonists; Female; GABA Antagonists; gamma-Aminobutyric Acid; Gene Expression Regulation; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine 5'-O-(3-Thiotriphosphate); Hot Temperature; Humans; Hyperalgesia; Inhibitory Postsynaptic Potentials; Isotopes; Male; Methadone; Mice; Mice, Transgenic; Morphine; Mutation; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Oligopeptides; Pain Measurement; Patch-Clamp Techniques; Pertussis Toxin; Protein Binding; Reaction Time; RGS Proteins; Signal Transduction; Spinal Cord | 2013 |
Rewarding effects of ethanol combined with low doses of morphine through dopamine D1 receptors.
Topics: Analgesics, Opioid; Animals; Benzazepines; Central Nervous System Depressants; Conditioning, Psychological; Dose-Response Relationship, Drug; Ethanol; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Reward | 2013 |
Co-activation of μ- and δ-opioid receptors elicits tolerance to morphine-induced ventilatory depression via generation of peroxynitrite.
Topics: Analysis of Variance; Animals; Antidotes; Drug Tolerance; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Penicillamine; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Respiratory Insufficiency; Time Factors | 2013 |
μ-opioid receptors in the stimulation of mesolimbic dopamine activity by ethanol and morphine in Long-Evans rats: a delayed effect of ethanol.
Topics: Animals; Dopamine; Dose-Response Relationship, Drug; Ethanol; Injections, Intravenous; Injections, Subcutaneous; Male; Microdialysis; Microinjections; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Long-Evans; Receptors, Opioid, mu; Time Factors; Ventral Tegmental Area | 2013 |
The in vivo pharmacodynamics of the novel opioid receptor antagonist, TD-1211, in models of opioid-induced gastrointestinal and CNS activity.
Topics: Administration, Oral; Analgesics, Opioid; Animals; Benzamides; Central Nervous System; Dogs; Female; Gastrointestinal Tract; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Pain; Piperidines; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Tropanes | 2013 |
The interaction of adenosine and morphine on pentylenetetrazole-induced seizure threshold in mice.
Topics: Adenosine; Animals; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Pentylenetetrazole; Seizures; Xanthines | 2013 |
Role of the endogenous opioid system in modulation of urinary bladder activity by spinal nerve stimulation.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Electric Stimulation; Female; Morphine; Muscle Contraction; Naltrexone; Narcotic Antagonists; Neural Inhibition; Opioid Peptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Spinal Nerves; Time Factors; Urinary Bladder; Urination | 2013 |
Synthesis, modeling, and pharmacological evaluation of UMB 425, a mixed μ agonist/δ antagonist opioid analgesic with reduced tolerance liabilities.
Topics: Analgesics, Opioid; Animals; CHO Cells; Computer Simulation; Cricetulus; Drug Evaluation, Preclinical; Drug Tolerance; Humans; Male; Mice; Models, Chemical; Molecular Structure; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptive Pain; Pain Measurement; Protein Binding; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship; Thebaine; Transfection | 2013 |
Morphine treatment selectively regulates expression of rat pituitary POMC and the prohormone convertases PC1/3 and PC2.
Topics: Animals; Cyclic AMP Response Element-Binding Protein; Gene Expression Regulation; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Pituitary Gland; Pro-Opiomelanocortin; Proprotein Convertase 1; Proprotein Convertase 2; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2013 |
Pain-related depression of the mesolimbic dopamine system in rats: expression, blockade by analgesics, and role of endogenous κ-opioids.
Topics: Analgesics, Opioid; Animals; Benzeneacetamides; Depression; Disease Models, Animal; Dopamine; Gene Expression Regulation; Ketoprofen; Lactic Acid; Male; Medial Forebrain Bundle; Morphine; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Pain; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Self Stimulation; Time Factors | 2014 |
Impact of organic solvent additive on the integrity of plasma samples in bioanalysis by LC-MS/MS.
Topics: Chromatography, High Pressure Liquid; Humans; Lipids; Morphine; Morphine Derivatives; Naltrexone; Organic Chemicals; Pharmaceutical Preparations; Quality Control; Reference Standards; Solvents; Tandem Mass Spectrometry | 2013 |
Morphine intake and the effects of naltrexone and buprenorphine on the acquisition of methamphetamine intake.
Topics: Amphetamine-Related Disorders; Animals; Buprenorphine; Choice Behavior; Female; Inbreeding; Male; Methamphetamine; Mice; Morphine; Naltrexone; Narcotic Antagonists; Selection, Genetic | 2014 |
Antinociceptive activity of a synthetic oxopyrrolidine-based compound, ASH21374, and determination of its possible mechanisms.
Topics: Analgesics; Analgesics, Opioid; Animals; Aspirin; Capsaicin; Cyclic GMP; Glutamic Acid; Male; Mice; Mice, Inbred BALB C; Morphine; Motor Activity; Naloxone; Naltrexone; Nitric Oxide; Pyrrolidines; Rats, Sprague-Dawley; Receptors, Opioid | 2013 |
Opioid analgesics stop the development of clostridial gas gangrene.
Topics: Analgesics, Opioid; Animals; Buprenorphine; Clostridium perfringens; Female; Gas Gangrene; Mice; Mice, Inbred BALB C; Morphine; Naltrexone | 2014 |
C-Fos activation in the periaqueductal gray following acute morphine-3β-D-glucuronide or morphine administration.
Topics: Animals; Central Nervous System Stimulants; Hyperalgesia; Immunohistochemistry; Male; Mice, Inbred Strains; Microscopy, Confocal; Morphine; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Narcotics; Neurons; Pain Threshold; Periaqueductal Gray; Proto-Oncogene Proteins c-fos; Random Allocation | 2014 |
Opioid/NMDA receptors blockade reverses the depressant-like behavior of foot shock stress in the mouse forced swimming test.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Depression; Dizocilpine Maleate; Electroshock; Foot; Male; Mice; Morphine; Motor Activity; N-Methylaspartate; Naltrexone; Narcotic Antagonists; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Stress, Psychological; Swimming | 2014 |
Prolonged morphine treatment alters δ opioid receptor post-internalization trafficking.
Topics: Analgesics, Opioid; Animals; Benzamides; Cells, Cultured; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Ganglia, Spinal; Male; Mice, Knockout; Morphine; Naltrexone; Neurons; Oligopeptides; Piperazines; Protein Transport; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu | 2015 |
Effect of naltrexone on neuropathic pain in mice locally transfected with the mutant μ-opioid receptor gene in spinal cord.
Topics: Analgesics; Animals; Conditioning, Psychological; Genetic Vectors; HEK293 Cells; Humans; Lentivirus; Male; Mice, Inbred C57BL; Morphine; Mutation; Naltrexone; Narcotic Antagonists; Neuralgia; Receptors, Opioid, mu; Reward; Spinal Cord; Spinal Nerves; Substance Withdrawal Syndrome; Transfection | 2015 |
Operant nociception in nonhuman primates.
Topics: Analgesics, Opioid; Animals; Conditioning, Operant; Hot Temperature; Male; Morphine; Naltrexone; Nociception; Pain; Pain Measurement; Pain Threshold; Saimiri | 2014 |
The opioid receptor pharmacology of GSK1521498 compared to other ligands with differential effects on compulsive reward-related behaviours.
Topics: Analgesics, Opioid; Animals; CHO Cells; Compulsive Behavior; Cricetinae; Cricetulus; Guanosine 5'-O-(3-Thiotriphosphate); HEK293 Cells; Humans; Indans; Ligands; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Protein Binding; Receptors, Opioid, mu; Reward; Treatment Outcome; Triazoles | 2015 |
Epigenetic regulation of spinal cord gene expression controls opioid-induced hyperalgesia.
Topics: Analgesics, Opioid; Animals; Antineoplastic Agents; Azepines; Benzamides; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Dynorphins; Epigenesis, Genetic; Gene Expression Regulation; Hydroxamic Acids; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Morphine; Naltrexone; Narcotic Antagonists; Pain Measurement; Spinal Cord; Vorinostat | 2014 |
Sustained pain-related depression of behavior: effects of intraplantar formalin and complete freund's adjuvant on intracranial self-stimulation (ICSS) and endogenous kappa opioid biomarkers in rats.
Topics: Analgesics, Opioid; Animals; Body Weight; Conditioning, Operant; Disease Models, Animal; Formaldehyde; Freund's Adjuvant; Hyperalgesia; Inhibition, Psychological; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Self Stimulation | 2014 |
Downregulation of spinal endomorphin-2 correlates with mechanical allodynia in a rat model of tibia cancer.
Topics: Analgesics; Animals; Bone Neoplasms; Disease Models, Animal; Down-Regulation; Female; Hyperalgesia; Morphine; Naltrexone; Narcotic Antagonists; Oligopeptides; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Tibia | 2015 |
The kappa-opioid receptor antagonist, nor-binaltorphimine (nor-BNI), decreases morphine withdrawal and the consequent conditioned place aversion in rats.
Topics: Animals; Conditioning, Psychological; Defecation; Dynorphins; Male; Morphine; Morphine Dependence; Motor Activity; Naltrexone; Narcotic Antagonists; Narcotics; Neurotransmitter Agents; Random Allocation; Rats, Long-Evans; Receptors, Opioid, kappa; Spatial Behavior; Substance Withdrawal Syndrome | 2015 |
Implication of delta opioid receptor subtype 2 but not delta opioid receptor subtype 1 in the development of morphine analgesic tolerance in a rat model of chronic inflammatory pain.
Topics: Analgesics, Opioid; Animals; Benzylidene Compounds; Chronic Pain; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Tolerance; Freund's Adjuvant; Hindlimb; Inflammation; Male; Morphine; Naltrexone; Narcotic Antagonists; Rats, Sprague-Dawley; Receptors, Opioid, delta | 2015 |
Low-dose naltrexone to prevent intolerable morphine adverse events: a forgotten remedy for a neglected, global clinical need.
Topics: Analgesics, Opioid; Chronic Pain; Dose-Response Relationship, Drug; Humans; Morphine; Naltrexone; Narcotic Antagonists; Neoplasms | 2015 |
Enkephalin analog, cyclo[N(ε),N(β)-carbonyl-D-Lys(2),Dap(5)] enkephalinamide (cUENK6), inhibits the ethanol withdrawal-induced anxiety-like behavior in rats.
Topics: Analgesics, Opioid; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Central Nervous System Depressants; Enkephalin, Leucine; Enkephalins; Ethanol; Morphine; Naltrexone; Narcotic Antagonists; Neurotransmitter Agents; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Substance Withdrawal Syndrome | 2015 |
Chorionic morphine, naltrexone and pentoxifylline effect on hypophyso-gonadal hormones of male rats.
Topics: Animals; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Gonadotropins, Pituitary; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Pentoxifylline; Phosphodiesterase Inhibitors; Rats; Rats, Wistar; Reproduction; Substance-Related Disorders; Testosterone | 2015 |
High-dose pentazocine antagonizes the antinociception induced by high-dose morphine.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred C57BL; Morphine; Naltrexone; Pain; Pentazocine; Receptors, Opioid, kappa | 2015 |
Rutin antinociception involves opioidergic mechanism and descending modulation of ventrolateral periaqueductal grey matter in rats.
Topics: Animals; Male; Microinjections; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Nociception; Pain; Pain Measurement; Periaqueductal Gray; Rats; Rats, Wistar; Receptors, Opioid; Rutin; Tramadol | 2016 |
Behavioral and neurochemical analysis of ongoing bone cancer pain in rats.
Topics: Adenocarcinoma; Analgesics, Opioid; Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Bone Neoplasms; Cell Line, Tumor; Diclofenac; Disease Models, Animal; Female; Gyrus Cinguli; Lidocaine; Morphine; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Pain; Rats; Rats, Inbred F344 | 2015 |
Spinal and supraspinal N-methyl-D-aspartate and melanocortin-1 receptors contribute to a qualitative sex difference in morphine-induced hyperalgesia.
Topics: Analgesics, Opioid; Animals; Brain Stem; Dose-Response Relationship, Drug; Drug Administration Routes; Female; Hyperalgesia; Male; Mice; Morphine; Naltrexone; Ovariectomy; Pain Measurement; Progesterone; Progestins; Reaction Time; Receptor, Melanocortin, Type 1; Receptors, N-Methyl-D-Aspartate; Sex Characteristics; Spinal Cord | 2015 |
Structure-Activity Relationships of (+)-Naltrexone-Inspired Toll-like Receptor 4 (TLR4) Antagonists.
Topics: Analgesics, Opioid; Animals; Cell Line; Drug Synergism; Humans; Lipopolysaccharides; Male; Microglia; Morphinans; Morphine; Naltrexone; Nitric Oxide; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Toll-Like Receptor 4 | 2015 |
Mediation of opioid analgesia by a truncated 6-transmembrane GPCR.
Topics: Alternative Splicing; Analgesics, Opioid; Animals; Exons; Gene Targeting; Methadone; Mice; Mice, Knockout; Morphine; Naltrexone; Pain; Peptide Fragments; Protein Structure, Tertiary; Receptors, Opioid, mu; Recombinant Proteins | 2015 |
Development and validation of a bioanalytical method for the simultaneous determination of heroin, its main metabolites, naloxone and naltrexone by LC-MS/MS in human plasma samples: Application to a clinical trial of oral administration of a heroin/naloxo
Topics: Administration, Oral; Calibration; Chromatography, Liquid; Codeine; Formates; Healthy Volunteers; Heroin; Humans; Hydrogen-Ion Concentration; Limit of Detection; Morphine; Naloxone; Naltrexone; Quality Control; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Substance Abuse Detection; Tandem Mass Spectrometry | 2015 |
Antagonism of κ opioid receptor in the nucleus accumbens prevents the depressive-like behaviors following prolonged morphine abstinence.
Topics: Animals; Antidepressive Agents; Depressive Disorder; Disease Models, Animal; Dose-Response Relationship, Drug; Enkephalins; Male; Mice, Inbred C57BL; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Narcotics; Nucleus Accumbens; Protein Precursors; Receptors, Opioid, kappa; RNA, Messenger; Substance Withdrawal Syndrome | 2015 |
Morphine Modulates Interleukin-4- or Breast Cancer Cell-induced Pro-metastatic Activation of Macrophages.
Topics: Animals; Arginase; Bone Marrow Cells; Cell Differentiation; Cell Line; Cell Line, Tumor; Cell Movement; Coculture Techniques; Female; Gene Expression Regulation, Neoplastic; Humans; Interleukin-4; Macrophage Activation; Macrophages; Mammary Glands, Animal; Matrix Metalloproteinase 9; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Morphine; Naloxone; Naltrexone; Quaternary Ammonium Compounds; Receptors, Cell Surface; Receptors, Immunologic; Signal Transduction | 2015 |
Technology: Barriers to misuse.
Topics: Analgesics, Opioid; Chemistry, Pharmaceutical; Drug Combinations; Drug Overdose; Drug Users; Humans; Morphine; Naltrexone; Opioid-Related Disorders; Oxycodone; Prodrugs | 2015 |
Morphine modulates the effects of histamine H1 and H3 receptors on seizure susceptibility in pentylenetetrazole-induced seizure model of mice.
Topics: Animals; Disease Models, Animal; Disease Susceptibility; Dose-Response Relationship, Drug; Histamine Agonists; Histamine Antagonists; Male; Mice; Morphine; Naltrexone; Pentylenetetrazole; Receptors, Histamine H1; Receptors, Histamine H3; Seizures | 2015 |
Differences in the morphine-induced inhibition of small and large intestinal transit: Involvement of central and peripheral μ-opioid receptors in mice.
Topics: Analgesics, Opioid; Animals; Central Nervous System; Dose-Response Relationship, Drug; Gastrointestinal Transit; Injections, Intraventricular; Intestine, Large; Intestine, Small; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Peripheral Nervous System; Receptors, Opioid, mu | 2016 |
A stability-indicating HPLC method for simultaneous determination of morphine and naltrexone.
Topics: Chromatography, High Pressure Liquid; Drug Stability; Linear Models; Morphine; Naltrexone; Reproducibility of Results; Sensitivity and Specificity | 2016 |
Cannabidiol disrupts the reconsolidation of contextual drug-associated memories in Wistar rats.
Topics: Animals; Cannabidiol; Cocaine; Conditioning, Classical; Cues; Disease Models, Animal; Male; Memory; Mental Recall; Morphine; Naltrexone; Rats; Rats, Wistar; Reward | 2017 |
The interaction between morphine and propranolol in chemical and electrical seizure models of mice.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Administration Schedule; Drug Interactions; Electroshock; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Pentylenetetrazole; Propranolol; Seizures; Time Factors | 2016 |
Methylnaltrexone for the Treatment of Constipation in Critically Ill Children.
Topics: Abdominal Pain; Analgesics, Opioid; Child; Constipation; Critical Illness; Defecation; Humans; Infant; Laxatives; Male; Morphine; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Treatment Outcome | 2016 |
Truncated mu opioid GPCR variant involvement in opioid-dependent and opioid-independent pain modulatory systems within the CNS.
Topics: Alternative Splicing; Analgesia; Analgesics, Opioid; Animals; Female; Humans; Male; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Morphine; Naltrexone; Pain Management; Pain Measurement; Protein Isoforms; Protein Structure, Tertiary; Receptors, Opioid, mu | 2016 |
Preferential Delivery of an Opioid Antagonist to the Fetal Brain in Pregnant Mice.
Topics: Animals; Behavior, Animal; Brain; Dose-Response Relationship, Drug; Female; Mice, Inbred C57BL; Morphine; Naltrexone; Narcotic Antagonists; Placenta; Pregnancy; Substance Withdrawal Syndrome; Tissue Distribution | 2016 |
Enhancement of Cisplatin Nephrotoxicity by Morphine and Its Attenuation by the Opioid Antagonist Naltrexone.
Topics: Acute Kidney Injury; Analgesics, Opioid; Animals; Antineoplastic Agents; Blood Urea Nitrogen; Cisplatin; Creatinine; Drug Synergism; Drug Therapy, Combination; Glutathione; Glutathione Peroxidase; Humans; Interleukin-1beta; Kidney; Male; Morphine; Naltrexone; Narcotic Antagonists; Rats; Superoxide Dismutase; Tumor Necrosis Factor-alpha | 2016 |
Study on the molecular mechanism of antinociception induced by ghrelin in acute pain in mice.
Topics: Acute Pain; Analgesics; Animals; Ghrelin; Humans; Male; Mice; Morphine; Naltrexone; Oligopeptides; Receptors, Ghrelin; Receptors, Opioid, delta | 2016 |
Rearing environment differentially modulates cocaine self-administration after opioid pretreatment: A behavioral economic analysis.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Cocaine; Economics, Behavioral; Environment; Male; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Self Administration; Substance-Related Disorders; Time Factors | 2016 |
Morphine amplifies mechanical allodynia via TLR4 in a rat model of spinal cord injury.
Topics: Analgesics, Opioid; Animals; Hyperalgesia; Male; Morphine; Naltrexone; Neuralgia; Rats, Sprague-Dawley; Spinal Cord Injuries; Toll-Like Receptor 4 | 2016 |
Lithium attenuated the behavioral despair induced by acute neurogenic stress through blockade of opioid receptors in mice.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Lithium; Male; Mice; Morphine; Naltrexone; Receptors, Opioid; Stress, Psychological; Swimming | 2016 |
The µ-opioid system promotes visual attention to faces and eyes.
Topics: Adult; Analgesics, Opioid; Attention; Cues; Eye Movements; Face; Humans; Male; Morphine; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu; Reward; Social Behavior; Visual Perception; Young Adult | 2016 |
Sweet taste pleasantness is modulated by morphine and naltrexone.
Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Double-Blind Method; Eating; Emotions; Food Preferences; Humans; Male; Morphine; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu; Sucrose; Sweetening Agents; Taste; Young Adult | 2016 |
Nor-Binaltorphimine Blocks the Adverse Effects of Morphine after Spinal Cord Injury.
Topics: Animals; Disease Models, Animal; Drug-Related Side Effects and Adverse Reactions; Male; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Narcotics; Nociception; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Recovery of Function; Spinal Cord Injuries | 2017 |
Pentoxifylline besides naltrexone recovers morphine-induced inflammation in male reproductive system of rats by regulating Toll-like receptor pathway.
Topics: Animals; Drug Evaluation, Preclinical; Genital Diseases, Male; Genitalia, Male; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Pentoxifylline; Phosphodiesterase Inhibitors; Rats, Wistar; Toll-Like Receptors | 2017 |
Loss of μ opioid receptor signaling in nociceptors, but not microglia, abrogates morphine tolerance without disrupting analgesia.
Topics: Analgesia; Analgesics, Opioid; Animals; Chronic Pain; Disease Models, Animal; Drug Tolerance; Gene Deletion; Hyperalgesia; Long-Term Potentiation; Mice; Mice, Knockout; Microglia; Morphine; Naltrexone; Nociception; Nociceptors; Pain, Postoperative; Quaternary Ammonium Compounds; Receptors, Opioid, mu; Signal Transduction; Spinal Cord | 2017 |
New opioid receptor antagonist: Naltrexone-14-O-sulfate synthesis and pharmacology.
Topics: Analgesics; Animals; Behavior, Animal; Chemistry Techniques, Synthetic; Colon; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid; Vas Deferens | 2017 |
Opioid system contribution to the antidepressant-like action of m-trifluoromethyl-diphenyl diselenide in mice: A compound devoid of tolerance and withdrawal syndrome.
Topics: Analgesics, Opioid; Animals; Antidepressive Agents; Behavior, Animal; Depression; Depressive Disorder; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Organosilicon Compounds; Receptors, Opioid, kappa; Substance Withdrawal Syndrome; Swimming | 2017 |
Maintenance on naltrexone+amphetamine decreases cocaine-vs.-food choice in male rhesus monkeys.
Topics: Administration, Intravenous; Animals; Choice Behavior; Cocaine; Dextroamphetamine; Dose-Response Relationship, Drug; Drug Interactions; Food; Macaca mulatta; Male; Morphine; Naltrexone; Receptors, Opioid, mu; Reinforcement, Psychology; Self Administration | 2017 |
Role of central versus peripheral opioid system in antinociceptive and anti-inflammatory effect of botulinum toxin type A in trigeminal region.
Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents; Botulinum Toxins, Type A; Dura Mater; Male; Migraine Disorders; Morphine; Naltrexone; Narcotic Antagonists; Neurogenic Inflammation; Neuromuscular Agents; Nociception; Pain; Pain Measurement; Quaternary Ammonium Compounds; Rats; Rats, Wistar; Sciatic Nerve; Trigeminal Caudal Nucleus; Trigeminal Nerve | 2018 |
To probe interaction of morphine and IBNtxA with 7TM and 6TM variants of the human μ-opioid receptor using all-atom molecular dynamics simulations with an explicit membrane.
Topics: Amino Acid Sequence; Animals; Binding Sites; Humans; Ligands; Mice; Molecular Dynamics Simulation; Morphine; Mutagenesis; Naltrexone; Protein Domains; Receptors, Opioid, mu; Sequence Alignment | 2018 |
Lateralized kappa opioid receptor signaling from the amygdala central nucleus promotes stress-induced functional pain.
Topics: Analgesics, Opioid; Animals; Capsaicin; Central Amygdaloid Nucleus; Dynorphins; Hypothalamus; Male; Medulla Oblongata; Morphine; Naltrexone; Narcotic Antagonists; Pain; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Stress, Physiological | 2018 |
Morphine induces changes in the gut microbiome and metabolome in a morphine dependence model.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Deoxycholic Acid; Disease Models, Animal; Drug Tolerance; Dysbiosis; Enterococcus faecalis; Female; Gastrointestinal Microbiome; Metabolome; Mice; Mice, Inbred C57BL; Morphine; Morphine Dependence; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Phosphatidylethanolamines; Statistics, Nonparametric | 2018 |
Naltrexone maintenance fails to alter amphetamine effects on intracranial self-stimulation in rats.
Topics: Amphetamine; Animals; Central Nervous System Stimulants; Cocaine; Deep Brain Stimulation; Dose-Response Relationship, Drug; Male; Medial Forebrain Bundle; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Sprague-Dawley; Self Stimulation; Substance-Related Disorders | 2018 |
Abuse liability and therapeutic potential of the Mitragyna speciosa (kratom) alkaloids mitragynine and 7-hydroxymitragynine.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Mitragyna; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Secologanin Tryptamine Alkaloids; Self Administration | 2019 |
Methylation Products of 6β- N-Heterocyclic Substituted Naltrexamine Derivatives as Potential Peripheral Opioid Receptor Modulators.
Topics: Analgesics, Opioid; Animals; CHO Cells; Constipation; Cricetulus; Diarrhea; Drug Partial Agonism; Gastrointestinal Agents; Gastrointestinal Transit; Imidazoles; Methylation; Mice; Molecular Docking Simulation; Morphine; Naltrexone; Narcotic Antagonists; Nociception; Phenylalanine; Quaternary Ammonium Compounds; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2018 |
Naltrexone and nalmefene attenuate cocaine place preference in male mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics, Opioid; Animals; Cocaine; Conditioning, Psychological; Dose-Response Relationship, Drug; Locomotion; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists | 2018 |
Evaluation of samidorphan, a μ-opioid antagonist, in a drug discrimination assay in rats.
Topics: Animals; Discrimination, Psychological; Dose-Response Relationship, Drug; Humans; Male; Morphine; Naltrexone; Narcotic Antagonists; Rats, Sprague-Dawley; Receptors, Opioid, mu | 2018 |
Pharmacological Characterization of Dezocine, a Potent Analgesic Acting as a κ Partial Agonist and μ Partial Agonist.
Topics: Analgesics, Opioid; Animals; Bridged Bicyclo Compounds, Heterocyclic; CHO Cells; Cricetulus; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Female; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Nociception; Pain Measurement; Protein Binding; Receptors, Opioid, kappa; Receptors, Opioid, mu; Signal Transduction; Tetrahydronaphthalenes | 2018 |
Short term exposure to oxycodone alters the survival, proliferation and differentiation of rat embryonic neural stem cell in vitro.
Topics: Analgesics, Opioid; Animals; Apoptosis; Cell Differentiation; Cell Proliferation; Cell Survival; Embryonic Stem Cells; Female; Morphine; Naltrexone; Neural Stem Cells; Oxycodone; Pregnancy; Rats; Rats, Sprague-Dawley | 2018 |
Extended-release morphine sulfate and naltrexone hydrochloride (EMBEDA): naltrexone-associated withdrawal and abuse-related effects in patients with chronic pain and recreational opioid users.
Topics: Adult; Chronic Pain; Delayed-Action Preparations; Drug Combinations; Female; Humans; Male; Middle Aged; Morphine; Naltrexone; Opioid-Related Disorders; Substance Withdrawal Syndrome | 2019 |
Pharmacological classification of centrally acting drugs using EEG in freely moving rats: an old tool to identify new atypical dopamine uptake inhibitors.
Topics: Animals; Central Nervous System Agents; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Discovery; Electroencephalography; Heroin; Ketamine; Male; Methylphenidate; Modafinil; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 2019 |
Effectiveness comparisons of G-protein biased and unbiased mu opioid receptor ligands in warm water tail-withdrawal and drug discrimination in male and female rats.
Topics: Analgesics, Opioid; Animals; Discrimination Learning; Female; Fentanyl; Male; Morphine; Naltrexone; Narcotic Antagonists; Nociception; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Spiro Compounds; Thiophenes | 2019 |
Real-world misuse, abuse, and dependence of abuse-deterrent versus non-abuse-deterrent extended-release morphine in Medicaid non-cancer patients.
Topics: Adolescent; Adult; Analgesics, Opioid; Cohort Studies; Delayed-Action Preparations; Female; Humans; Male; Medicaid; Middle Aged; Morphine; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Patient Acceptance of Health Care; Prescription Drug Misuse; Retrospective Studies; United States; Young Adult | 2019 |
Suppression of Human Natural Killer Cells by Different Classes of Opioids.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Anesthesia; Buprenorphine; Enkephalin, D-Penicillamine (2,5)-; Fentanyl; Fluoresceins; Humans; Immunosuppression Therapy; K562 Cells; Killer Cells, Natural; Loperamide; Methadone; Morphinans; Morphine; Naloxone; Naltrexone; Succinimides; Toll-Like Receptor 4; Tramadol | 2019 |
Study on structural insight of the analysis of negative effects of opioids analgesics in naltrexone with TLR4 Mutations.
Topics: Analgesics, Opioid; Humans; Morphine; Mutation; Naltrexone; Narcotic Antagonists; Toll-Like Receptor 4 | 2019 |
μ-Opioid receptor in the CA1 involves in tramadol and morphine cross state-dependent memory.
Topics: Amnesia; Animals; Avoidance Learning; CA1 Region, Hippocampal; Dose-Response Relationship, Drug; Drug Interactions; Male; Memory; Mental Recall; Microinjections; Morphine; Naltrexone; Rats; Receptors, Opioid, mu; Tramadol | 2019 |
A preliminary study of the effect of naldemedine tosylate on opioid-induced nausea and vomiting.
Topics: Aged; Analgesics, Opioid; Antiemetics; Constipation; Female; Humans; Incidence; Male; Middle Aged; Morphine; Naltrexone; Narcotic Antagonists; Nausea; Oxycodone; Receptors, Opioid; Retrospective Studies; Vomiting | 2020 |
Cross-talk between Human Spinal Cord μ-opioid Receptor 1Y Isoform and Gastrin-releasing Peptide Receptor Mediates Opioid-induced Scratching Behavior.
Topics: Aged; Analgesics, Opioid; Animals; Behavior, Animal; Cadaver; Disease Models, Animal; Humans; Male; Mice; Mice, Inbred C57BL; Morphine; Naltrexone; Narcotic Antagonists; Pruritus; Receptors, Bombesin; Receptors, Opioid, mu; Spinal Cord | 2019 |
Methylnaltrexone to Reduce the Inhibitory Effects of Opioids on Drug Absorption.
Topics: Analgesics, Opioid; Coronary Artery Disease; Humans; Morphine; Naltrexone; Quaternary Ammonium Compounds; Ticagrelor; Treatment Outcome | 2019 |
Effectiveness and selectivity of a heroin conjugate vaccine to attenuate heroin, 6-acetylmorphine, and morphine antinociception in rats: Comparison with naltrexone.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Administration Routes; Female; Fentanyl; Heroin; Male; Morphine; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Rats; Tetanus Toxoid; Vaccination | 2019 |
Changes in fentanyl demand following naltrexone, morphine, and buprenorphine in male rats.
Topics: Animals; Buprenorphine; Dose-Response Relationship, Drug; Drug Interactions; Fentanyl; Male; Morphine; Naltrexone; Rats; Receptors, Opioid; Receptors, Opioid, mu; Reinforcement Schedule; Self Administration | 2020 |
Morphine induces the differentiation of T helper cells to Th2 effector cells via the PKC-θ-GATA3 pathway.
Topics: Analgesics, Opioid; Animals; Cell Differentiation; GATA3 Transcription Factor; Interferon-gamma; Interleukin-4; Male; Mice, Inbred C57BL; Morphine; Naltrexone; Narcotic Antagonists; Protein Kinase C-theta; Pyrroles; Quinazolines; T-Lymphocytes, Helper-Inducer | 2020 |
Sigma receptor-induced heavy drinking in rats: Modulation by the opioid receptor system.
Topics: Animals; Binge Drinking; Central Nervous System Depressants; Dose-Response Relationship, Drug; Ethanol; Guanidines; Male; Morphine; Naltrexone; Narcotic Antagonists; Rats; Receptors, sigma; Self Administration | 2020 |
Antagonism of peripheral opioid receptors by methylnaltrexone does not prevent morphine tolerance in rats.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Male; Morphine; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, mu | 2022 |
Single-molecule analysis reveals agonist-specific dimer formation of µ-opioid receptors.
Topics: Animals; beta-Arrestins; CHO Cells; Cricetulus; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Fluorescence Resonance Energy Transfer; Morphine; Mutation; Naloxone; Naltrexone; Narcotic Antagonists; Phosphorylation; Protein Multimerization; Receptors, Opioid, mu; Single Molecule Imaging | 2020 |
Behavioral effects of benzylideneoxymorphone (BOM), a low efficacy µ opioid receptor agonist and a δ opioid receptor antagonist.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Male; Morphine; Naltrexone; Narcotic Antagonists; Oxymorphone; Pain; Pain Measurement; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Reinforcement, Psychology; Self Administration | 2020 |
The role of opioidergic system in modulating cost/benefit decision-making in alcohol-preferring AA rats and Wistar rats.
Topics: Alcohol Drinking; Analgesics, Opioid; Animals; Behavior, Animal; Cost-Benefit Analysis; Decision Making; Gambling; Male; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Reward; Sucrose | 2021 |
Methylnaltrexone crosses the blood-brain barrier and attenuates centrally-mediated behavioral effects of morphine and oxycodone in mice.
Topics: Analgesics, Opioid; Animals; Blood-Brain Barrier; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred C57BL; Morphine; Naltrexone; Narcotic Antagonists; Oxycodone; Pain Measurement; Quaternary Ammonium Compounds | 2021 |
Systematic Structure-Based Virtual Screening Approach to Antibody Selection and Design of a Humanized Antibody against Multiple Addictive Opioids without Affecting Treatment Agents Naloxone and Naltrexone.
Topics: Analgesics, Opioid; Heroin; Morphine; Naloxone; Naltrexone | 2021 |
Characterization of a mouse neuropathic pain model caused by the highly active antiviral therapy (HAART) Stavudine.
Topics: Animals; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Morphine; Naltrexone; Neuralgia; Stavudine | 2021 |
Antinociceptive Efficacy of the µ-Opioid/Nociceptin Peptide-Based Hybrid KGNOP1 in Inflammatory Pain without Rewarding Effects in Mice: An Experimental Assessment and Molecular Docking.
Topics: Acute Pain; Analgesics; Animals; Behavior, Animal; CHO Cells; Cricetinae; Cricetulus; Cycloheptanes; Humans; Hyperalgesia; In Vitro Techniques; Inflammation; Male; Mice; Models, Molecular; Molecular Docking Simulation; Morphine; Movement; Naloxone; Naltrexone; Nociceptin; Oligopeptides; Opioid Peptides; Pain Management; Piperidines; Receptors, Opioid, mu | 2021 |
Morphine attenuates neuroinflammation and blood-brain barrier disruption following traumatic brain injury through the opioidergic system.
Topics: Analgesics, Opioid; Animals; Blood-Brain Barrier; Brain; Brain Injuries, Traumatic; Disease Models, Animal; Male; Morphine; Naltrexone; Neuroinflammatory Diseases; Neuroprotective Agents; Rats; Rats, Wistar | 2021 |
Opioid Antagonist Nanodrugs Successfully Attenuate the Severity of Ischemic Stroke.
Topics: Analgesics, Opioid; Animals; Ischemic Stroke; Mice; Morphine; Naloxone; Naltrexone; Nanoparticles; Narcotic Antagonists; Opioid-Related Disorders; Oxycodone; Stroke; Tight Junction Proteins | 2022 |
A Journey through Diastereomeric Space: The Design, Synthesis, In Vitro and In Vivo Pharmacological Activity, and Molecular Modeling of Novel Potent Diastereomeric MOR Agonists and Antagonists.
Topics: Animals; CHO Cells; Colforsin; Cricetinae; Ligands; Mice; Morphine; Naltrexone; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Respiratory Insufficiency | 2022 |
Functional consequences of short-term exposure to opioids versus cannabinoids in nonhuman primates.
Topics: Analgesics, Opioid; Animals; Cannabinoid Receptor Agonists; Cannabinoids; Dose-Response Relationship, Drug; Dronabinol; Female; Heroin; Male; Morphine; Naltrexone; Rimonabant | 2023 |
Promising biomedical subcutaneous delivery system in opioid disaccustom process: In vitro/in vivo evaluation of naloxone microparticles on antagonist effect of morphine.
Topics: Analgesics, Opioid; Animals; Guinea Pigs; Humans; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Neuroblastoma | 2023 |
Inhibitory Effects of a Novel μ-Opioid Receptor Nonpeptide Antagonist, UD-030, on Morphine-Induced Conditioned Place Preference.
Topics: Analgesics, Opioid; Animals; Humans; Mice; Mice, Inbred C57BL; Morphine; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Receptors, Opioid, delta; Receptors, Opioid, mu | 2023 |
Fentanyl analog structure-activity relationships demonstrate determinants of diverging potencies for antinociception and respiratory depression.
Topics: Analgesics, Opioid; Animals; Fentanyl; Hypoventilation; Male; Mice; Morphine; Naltrexone; Receptors, Opioid, mu | 2023 |
A MOR Antagonist with High Potency and Antagonist Efficacy among Diastereomeric C9-Alkyl-Substituted
Topics: Analgesics, Opioid; Morphinans; Morphine; Naltrexone; Receptors, Opioid, mu; Structure-Activity Relationship | 2023 |
Extinction and reinstatement of methamphetamine-induced conditioned place preference in zebrafish.
Topics: Animals; Clonidine; Extinction, Psychological; Methamphetamine; Morphine; Naltrexone; Recurrence; Zebrafish | 2023 |