naltrexone and morphine

naltrexone has been researched along with morphine in 1270 studies

Research

Studies (1,270)

TimeframeStudies, this research(%)All Research%
pre-1990375 (29.53)18.7374
1990's401 (31.57)18.2507
2000's292 (22.99)29.6817
2010's178 (14.02)24.3611
2020's24 (1.89)2.80

Authors

AuthorsStudies
Berkowitz, DS; Loew, GH1
Cheney, BV1
Fries, DS; Larson, DL; Portoghese, PS; Sayre, LM; Takemori, AE1
Alreja, BD; Larson, DL; Portoghese, PS1
Portoghese, PS; Takemori, AE3
Archer, S; Gillan, MG; Kosterlitz, HW; Osei-Gyimah, P1
Bousquet, AR; Howes, JF; Kotick, MP; Leland, DL; Polazzi, JO1
Bell, GI; Chen, Y; Kong, H; Raynor, K; Reisine, T; Yasuda, K; Yu, L1
Adapa, ID; Auh, JS; Berzetei-Gurske, IP; Brandt, SR; Craymer, K; Farrington, L; Haggart, D; Kennedy, JM; O'Brien, A; Polgar, WE; Rodriguez, L; Schwartz, RW; Toll, L; White, A1
Strassburg, CP; Tukey, RH1
Carrupt, PA; Crivori, P; Cruciani, G; Testa, B1
Topliss, JG; Yoshida, F1
Bidlack, JM; Cohen, DJ; Dehnhardt, CM; Duan, W; Lou, R; Wentland, MP1
Ananthan, S; Bartlett, JL; Bilsky, EJ; Davis, P; Dersch, CM; Khare, NK; Porreca, F; Rothman, RB; Saini, SK; Seitz, LE1
Chang, TK; Ensom, MH; Kiang, TK1
Jolivette, LJ; Ward, KW1
Broadbear, J; Carrington, S; Husbands, SM; Lewis, JW; Moynihan, HA; Nieland, NP; Traynor, JR; Woods, JH1
Hebbel, RP; Lunzer, MM; Portoghese, PS; Yekkirala, A1
Andricopulo, AD; Moda, TL; Montanari, CA1
Aceto, MD; Cami-Kobeci, G; Husbands, SM; Lewis, JW; Martinez-Bermejo, F; Neal, AP; Rennison, D1
Aceto, MD; Coop, A; Harris, LS; May, EL; Metcalf, MD; Traynor, JR; Woods, JH1
Al-Khrasani, M; Ballet, S; Benyhe, S; Borics, A; Feytens, D; Fürst, Z; Kövér, KE; Lovas, S; Tömböly, C; Tóth, G; Tourwé, D1
Lombardo, F; Obach, RS; Waters, NJ1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
Bidlack, JM; Bu, Y; Cohen, DJ; Lou, R; Lu, Q; VanAlstine, MA; Wentland, MP1
Aschenbach, LC; Cassidy, MP; Chen, J; Dewey, WL; Gabra, BH; Li, G; Selley, DE; Stevens, DL; Westkaemper, RB; Zhang, Y1
Broadbear, JH; Greedy, BM; Husbands, SM; Jales, AR; Lewis, JW; Moynihan, H; Purington, L; Rennison, D; Traynor, JR; Woods, JH1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Alelyunas, YW; Bui, K; Empfield, JR; McCarthy, D; Pelosi-Kilby, L; Shen, C; Spreen, RC1
Burgman, M; Grinnell, S; Haselton, N; Majumdar, S; Ocampo, J; Pasternak, AR; Pasternak, GW1
Fujii, H; Hasebe, K; Mochizuki, H; Nagase, H; Nakajima, M; Nemoto, T; Watanabe, A1
Fujii, H; Hasebe, K; Izumimoto, N; Mochizuki, H; Momen, S; Nagase, H; Nakajima, R; Nemoto, T; Yamamoto, N1
Fujii, H; Hirayama, S; Koyano, K; Mochizuki, H; Nagase, H; Nakajima, M; Nakao, K; Nemoto, T; Wada, N; Watanabe, A1
Burgman, M; Grinnell, S; Haselton, N; Le Rouzic, V; Majumdar, S; Nagakura, K; Ocampo, J; Pan, YX; Pasternak, AR; Pasternak, GW; Polikar, L; Subrath, J1
Akbarali, HI; Akubathini, SK; Beletskaya, IO; Chen, J; Dewey, WL; Elbegdorj, O; Gerk, PM; Scoggins, KL; Selley, DE; Stevens, DL; Yuan, Y; Zhang, F; Zhang, Y; Zhang, Z1
Dewey, WL; Kellogg, GE; Mosier, PD; Scoggins, KL; Selley, DE; Stevens, DL; Yuan, Y; Zaidi, SA; Zhang, Y1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Brockmöller, J; Friesacher, HR; Meyer, MJ; Neumann, VE; Tzvetkov, MV; Zdrazil, B1
Geller, I; Hartmann, RJ1
Capozza, RC; Schmitt, EE; Sendelbeck, LR2
Misra, AL; Pontani, RB2
Ahtee, L; Carlsson, A; Garcia-Sevilla, JA; Magnusson, T1
Moroni, F1
Caruso, TP; Larson, DL; Portoghese, PS; Takemori, AE2
Järbe, TU; Rollenhagen, C1
Smith, JB2
Ary, M; Chesarek, W; Lomax, P; Sorensen, SM1
Craviso, GL; Gascon, P; Musacchio, JM; Puig, MM1
Biggio, G; Costa, E; Guidotti, A1
Costa, E; Dill, RE1
Terenius, L2
Bohus, B; de Wied, D; Urban, I; van Ree, JM1
Blume, AJ1
Caruso, TP; Jiang, JB; Larson, DL; Portoghese, PS; Takemori, AE2
Cheney, DL; Costa, E; Moroni, F; Peralta, E2
Bruno, F; Iuliano, E; Paoletti, R; Racagni, G1
Cicero, TJ; Meyer, ER; Schainker, BA1
Downs, DA; Harrigan, SE2
Berkowitz, BA; Hynes, MD1
Croiset, G; de Rotte, GA; Goedemans, HJ; Thody, TJ; van Ree, JM; van Wimersma Greidanus, TB; Verspaget, H1
Järbe, TU; Loman, P; Swedberg, MD1
Fennessy, MR; Laska, FJ1
Bhargava, HN3
Harry, GJ; Rosecrans, JA1
Gellert, VF; Holtzman, SG1
Burks, TF; Stewart, JJ; Weisbrodt, NW1
Misra, AL; Pontani, RB; Vadlamani, NL1
D'Mello, GD; Pilcher, CW; Stolerman, IP1
Blumberg, H; Ikeda, C1
Johnson, JH; Maughan, GT; Rosecrans, JA1
Bailey, B; Diaz, J; Paul, L1
Berti, F; Bruno, F; Omini, C; Racagni, G1
Järbe, TU1
Appel, JB; Hernandez, LL; Holohean, AM1
Howes, JF; Schwope, AD; Wise, DL1
Gehrmann, JE; Killam, KF1
Colombel, MC; Jacob, J; Tremblay, E1
Holtzman, SG; Shannon, HE1
Frank, S; Malspeis, L; Notari, RE; Reuning, RH1
Brocco, MJ; Killam, KF; Robinson, CA1
Cheney, DL; Costa, E; Racagni, G; Zsilla, G2
Hanson, RN; Jiang, JB; Portoghese, PS; Takemori, AE1
Cheney, DL; Costa, E; Moroni, F1
Cash, C; King, LJ; Minnema, KH1
Eades, CG; Gilbert, PE; Huppler, RE; Martin, WR; Thompson, JA1
Ary, M; Lomax, P1
Foldes, FF; Knoll, J; Rich, J; Vizi, ES1
Gray, AP; Guardina, WJ2
Kalkwarf, DR; Sullivan, MF1
Arnold, DL; Granchelli, FE; Nelsen, L; Sheth, SG; Sidman, KR; Steber, WD; Strong, P2
Jhamandas, K; Sutak, M1
Berkowitz, BA; Finck, AD; Ngai, SH1
Geller, I; Hartmann, RJ; Ross, D1
McNamee, HB; Meyer, RE; Mirin, SM1
Chen, RC; Ho, AK1
Fishman, J; Hahn, EF; Norton, BI1
Dimaio, J; Nogrady, T1
Greenstein, RA; Mintz, J; O'Brien, CP; Woody, GE1
Kalkward, DR; Sullivan, MF1
Goldstein, A1
Chen, RP; Fishman, J; Gray, MI; Hahn, EF; Heilman, RD1
Berggren, A; Rubenson, A; Sillén, U1
Di Giulio, AM; Donadoni, ML; Finco, C; Germani, E; Gorio, A; Malosio, ML; Mantegazza, P; Tenconi, B1
Auerbach, SB; Grauer, SM; Tao, R1
Craft, RM; Dykstra, LA2
Maneckjee, R; Minna, JD1
Robinson, SR; Smotherman, WP1
Baraban, JM; Bhat, RV; Cole, AJ; Worley, PF1
Portoghese, PS; Sofuoglu, M; Takemori, AE1
Billings, B; Candido, J; Duttaroy, A; Inturrisi, CE; Lutfy, K; Sierra, V; Yoburn, BC1
Tang, RR; Tseng, LF1
Dickenson, AH; Kalso, EA; McQuay, HJ; Sullivan, AF1
Burke, TF; Comer, SD; Lewis, JW; Woods, JH1
Malmberg, AB; Yaksh, TL1
Billings, B; Candido, J; Duttaroy, A; Yoburn, BC1
Riley, AL; Smurthwaite, ST1
Abood, LG; Hashmi, M; Lerner-Marmarosh, N; Manda, S1
Crebolder, J; Maier, S; Parker, LA; Rennie, M1
Cabral, JD; Leedham, JA; Monroe, PJ; Robertson, B; Smith, DJ; Taylor, DA1
Bertalmio, AJ; Woods, JH1
Fujimoto, JM; Holmes, BB2
Flores, CM; Hornby, PJ; Hulihan-Giblin, BA; Kellar, KJ; Lumpkin, MD1
Song, SH; Takemori, AE1
Kastin, AJ; Kersh, D; Wyatt, A; Zadina, JE1
Katafuchi, T; Koizumi, K; Nagatomo, I1
Doty, P; Dykstra, LA; Johnson, AB; Picker, MJ1
Stewart, J; Wise, RA1
Fournié-Zaluski, MC; Noble, F; Roques, BP; Turcaud, S1
Stamidis, H; Young, GA1
Misawa, M; Nagase, H; Narita, M; Suzuki, T; Takahashi, Y1
Adler, MW; Bussiere, JL; Eisenstein, TK; Rogers, TJ2
Heller, J; Roskos, KV; Tefft, JA2
Holtzman, SG; Paronis, CA1
Goosen, C; Kornet, M; Van Ree, JM2
Misawa, M; Nagase, H; Narita, M; Suzuki, T2
Goldberg, SR; Grayson, NA; Jaffe, JH; Johnson, RE; Katz, JL; Rice, KC; Witkin, JM1
Abdelhamid, EE; Portoghese, PS; Sultana, M; Takemori, AE1
Adamson, WT; Blackford, S; Kuhn, CM; Windh, RT1
France, CP; Medzihradsky, F; Rice, KC; Seggel, MR; Winger, G; Woods, JH1
Mjanger, E; Yaksh, TL1
Chang, SC; Lutfy, K; Sierra, V; Yoburn, BC1
Agbas, A; Ahmed, MS; Cemerikic, B; Cheng, J1
Kaneto, H; Takahashi, M1
Carden, SE; Hofer, MA2
Jang, Y; Yoburn, BC1
Collins, JG; Kitahata, LM; Nakatani, K; Omote, K1
de Costa, BR; Drower, EJ; Hammond, DL; Rafferty, MF; Rice, KC; Stapelfeld, A1
Jessop, JJ; Taplits, MS1
Millard, WJ; Simpkins, JW; Swager, D1
Kaneto, H; Senda, T; Takahashi, M1
Kamei, J; Kasuya, Y; Tanihara, H2
Cowan, A; Li, SX; Liu-Chen, LY; Wheeler-Aceto, H1
Furuya, Y; Kaneko, T; Nakazawa, T; Yamatsu, K1
Sharpe, LG1
Song, ZH; Takemori, AE2
Adams, JU; Holtzman, SG1
Crisp, T; Perni, VC; Spanos, LJ; Stafinsky, JL; Uram, M; Weaver, MF1
Banks, WA; Kastin, AJ; Pearson, MA1
Chesley, S; Greenblatt, DJ; Lopez, F; Miller, LG; Schatzki, A; Shader, RI; Thompson, ML1
Duman, RS; Hayward, MD; Nestler, EJ1
Newsom, GC; Spain, JW1
Ariznavarreta, C; González-Quijano, MI; López-Calderón, A; Martín, AI; Treguerres, JA1
Arora, PK; McIntyre, T; Sei, Y; Skolnick, P; Yoshimoto, K1
Fuller, RW; Ornstein, PL; Perry, KW; Rasmussen, K; Stockton, ME; Swinford, RM1
Cone, EJ; Vaupel, DB1
Lutfy, K; Yoburn, BC1
Giordano, J; Hughes, RA; Sufka, KJ1
Pasternak, GW; Paul, D; Pick, CG1
Jacoby, HI; Martinez, RP; Raffa, RB; Schupsky, JJ1
Armario, A; Garvey, JS; Giralt, M; Hidalgo, J1
Kehoe, P; Shoemaker, W1
Allen, AR; Galizio, M1
Larson, DL; Portoghese, PS; Takemori, AE; Yim, CB1
Kaneto, H; Takahashi, M; Watanabe, J1
Allen, JT; Brostrom, PA; DeHaven-Hudkins, DL; Ferkany, JW; Kaplita, PV; Lesko, LJ; Mavunkel, BJ; Rzeszotarski, WJ; Steranka, LR1
Abbott, FV1
Lee, C; Rodgers, RJ1
Arts, KS; Fujimoto, JM1
Doty, MD; Mattox, SR; Young, AM1
Fudala, PJ; Heishman, SJ; Henningfield, JE; Johnson, RE1
Calcagnetti, DJ; Holtzman, SG1
Arora, PK; Fride, E; McIntyre, T; Sei, Y; Skolnick, P; Yoshimoto, K1
Bilsky, EJ; Marglin, SH; Reid, LD1
Abboud, TK; Afrasiabi, A; Davidson, J; Khoo, N; Reyes, A; Steffens, Z; Zhu, J1
Dionne, RA; Flores, CM; Hargreaves, KM; Mueller, GP1
Cone, EJ; Johnson, RE; Su, TP; Vaupel, DB1
Bayer, BM; Hernandez, M; Irvin, L1
Mucha, RF2
de Costa, BR; France, CP; Jacobson, AE; Rice, KC; Woods, JH1
Heyman, JS; Koslo, RJ; Porreca, F; Qi, JA; Sheldon, RJ1
Bayer, BM; Daussin, S; Hernandez, M; Irvin, L1
Barr, GA; Capuano, CA; Leibowitz, SF1
Ceresoli, G; Groppetti, A; Mandelli, V; Parenti, M1
Suh, HH; Tseng, LF2
LoPresti, D; Porreca, F; Ward, SJ1
Davenport, KE; Houdi, AA; Van Loon, GR1
Fukagawa, Y; Misawa, M; Nagase, H; Suzuki, T1
Kaneto, H; Senda, T; Takahashi, M; Tokuyama, S1
Mosberg, HI; Porreca, F; Qi, JA1
Hammer, RP; Ricalde, AA1
Balfour, HH; Gekker, G; Peterson, PK; Portoghese, PS; Sannerud, K; Sharp, BM1
Ben-Zvi, Z; Hurwitz, A; Looney, G; Sullins, M1
Adams, JU; Holtzman, SG; Paronis, CA1
Ayres, EA; Burks, TF; Davis, P1
Lutfy, K; Sierra, V; Yoburn, BC2
Abboud, TK; Afrasiabi, A; Chai, M; Lee, K; Mantilla, M; Reyes, A; Steffens, Z; Zhu, J1
Garrett, ER; Khan, PJ; Langguth, P1
Bryant, HU; Roudebush, RE1
Ahtee, L; Attila, LM; Carlson, KR1
Aranow, JS; Kelsey, JE; Matthews, RT1
Cowan, A; Murray, CW1
Costello, A; Dubner, R; Hargreaves, KM; Joris, J1
Bhargava, HN; Ramarao, P2
Akil, H; Trujillo, KA1
Conti, A; Marzanatti, M; Monopoli, A; Ongini, E; Trampus, M1
Arrigo-Reina, R1
Goldberg, SR; Katz, JL; Schindler, CW; Su, TP; Wu, XZ1
Cherubini, E; North, RA; Tokimasa, T1
Beilin, B; Gale, RP; Liebeskind, JC; Martin, FC; Shavit, Y1
Cheng, SW; North, WG; O'Connor, EF1
Holtzman, SG7
Gauvin, DV; Young, AM1
Costa, E; Mocchetti, I; Ritter, A1
Melzack, R; Tasker, RAR; Vaccarino, AL1
Bergman, J; Warren, PH1
Blass, EM; Kehoe, P2
Brady, LS; Bykov, V; Holaday, JW; Jacobson, AE; Long, JB; Rice, KC; Rothman, RB1
Bardo, MT; Neisewander, JL; Pierce, RC1
Niesink, RJ; Van Ree, JM1
Falls, WA; Kelsey, JE1
France, CP; Morse, WH1
France, CP; Woods, JH8
Fiserová, M; Metys, J1
Chavkin, C; Opheim, KE; Wimpey, TL1
Guitart, X; Nestler, EJ1
Ahmed, MS; Quarles, C; Schoof, T; Zhou, DH1
Bykov, V; Holaday, JW; Long, JB; Rice, KC; Rothman, RB1
Garzón, J; Sánchez-Blázquez, P2
Jackson, HC; Kitchen, I1
Boja, JW; Crisp, T; Schechter, MD; Stafinsky, JL1
Flores, CM; Hulihan-Giblin, BA; Kellar, KJ1
Aghajanian, GK; Rasmussen, K1
Garzón, J; Sánchez-Blázquez, P; Ulibarri, I1
Brase, DA; Dewey, WL; Han, YH; Lux, F1
Valentino, RJ; Wehby, RG2
Field, EA; Kuhn, CM1
Pert, A; Weber, RJ1
Attila, LM1
Harbison, RD; James, RC; Roberts, SM; Skoulis, NP1
Bechara, A; van der Kooy, D1
Linseman, MA1
Kotlińska, J; Langwiński, R1
Bansinath, M; Bhargava, HN; Das, S; Matwyshyn, GA1
Bodnar, RJ; Inturrisi, CE; Kest, B; Truesdell, LS; Yoburn, BC1
Pasternak, GW; Recht, LD1
Heyman, JS; Mosberg, HI; Mulvaney, SA; Porreca, F1
Christie, MJ; North, RA; Williams, JT1
Bechara, A; van der Kooy, D; Zito, KA1
Bardo, MT; Neisewander, JL1
Bykov, V; Holaday, JW; Jacobson, AE; Lessor, RA; McLean, S; Rice, KC; Rothman, RB1
Adams, JU; Andrews, JS; Hiller, JM; Holtzman, SG; Simon, EJ1
Liebeskind, JC; Pechnick, RN; Terman, GW1
Burks, TF; Fox, DA1
Larson, DL; Lipkowski, AW; Nagase, H; Portoghese, PS; Takemori, AE1
Nagase, H; Portoghese, PS; Takemori, AE1
Ho, BY; Naeseth, JS; Portoghese, PS; Takemori, AE1
Inturrisi, CE; Luke, MC; Pasternak, GW; Yoburn, BC1
James, RC; Millner, GC; Paule, MG; Roberts, SM; Wessinger, WD1
Emmanouil, DE; Ishii, MM; Quock, RM1
Bykov, V; Danks, JA; Holaday, JW; Jacobson, AE; Long, JB; Rice, KC; Rothman, RB; Tortella, FC1
Portoghese, PS; Schwartz, MM; Takemori, AE1
Bardo, MT; Ennis, RB; Neisewander, JL1
Di Chiara, G; Imperato, A1
Katoh, M; Kimura, T; Satoh, S1
Carino, MA; Horita, A; Yamawaki, S2
Di Chiara, G; Morelli, M1
Martin, WR; Wettstein, JG1
Hayes, AG; Skingle, M; Tyers, MB1
O'Neill, KA; Valentino, D1
Akil, H; Houghten, RA; Lewis, ME; Walker, JM; Woods, JH; Young, EA1
Lipkowski, AW; Portoghese, PS; Takemori, AE1
Flood, JF; Morley, JE1
Bansinath, M; Bhargava, HN1
Baratti, CM; Introini, IB; McGaugh, JL1
Harty, GJ; Onofrio, BM; Yaksh, TL1
Devane, GD; Gudelsky, GA; Koenig, JI; Meltzer, HY1
Gudelsky, GA; Koenig, JI; Meltzer, HY1
Fujimoto, JM; Roerig, SC; Tseng, LF1
Gaspari, J; Kleber, HD; Kosten, TR; Topazian, M1
Gardner, EL; Tempel, A; Zukin, RS1
Fries, DS; Larson, DL; Portoghese, PS; Takemori, AE; Ward, SJ1
Cho, TM; Nozaki, M1
Eisenberg, RM1
Cohen, AH; Goodman, RR; Inturrisi, CE; Pasternak, GW; Yoburn, BC1
Faris, PL; Komisaruk, BR; Mayer, AD; Rosenblatt, JS1
Mansour, A; Valenstein, ES1
Lookingland, KJ; Moore, KE2
Hayes, AG; Stewart, BR1
Holtzman, SG; Locke, KW2
Carr, KD; Feliu, AL; Fowler, JS; Holland, MJ; Simon, EJ1
Bell, RD; Cicero, TJ1
Cabib, S; Oliverio, A; Puglisi-Allegra, S1
Blank, MS; Catt, KJ; Dufau, ML; Fabbri, A2
Coscia, CJ; Devane, WA; Howlett, AC; Spain, JW1
Botros, S; Lipkowski, AW; Portoghese, PS; Takemori, AE1
Greenberg, AH; Kraut, RP1
Mayer, DJ; Watkins, LR1
Larson, DL; Portoghese, PS; Ronsisvalle, G; Takemori, AE1
Depaulis, A; Gale, RP; Liebeskind, JC; Martin, FC; Pechnick, RN; Shavit, Y; Terman, GW; Zane, CJ1
McLaughlin, PJ; Zagon, IS4
Adler, B; Inturrisi, CE; Nunes, FA; Pasternak, GW; Yoburn, BC1
Portoghese, PS; Schoenecker, JW; Takemori, AE1
Abood, LG; Dirksen, R; Gala, D; Reichman, M1
Hynes, MD; Leander, JD; Reel, JK; Zimmerman, DM1
Lieblich, I; Yirmiya, R1
Coscia, CJ; Spain, JW1
Cunningham, CL; Peris, J; Schwarz, KS1
Corrigall, WA; D'Onofrio, RM; Lei, H; Linseman, MA1
Miczek, KA; Winslow, JT1
Leshem, M1
Altman, DG; Barrowcliffe, MP; Jones, JG; Jordan, C; Konieczko, KM1
Calligaro, D; Khazan, N; Young, GA1
Bryant, HU; Kuta, CC; Story, JA; Yim, GK1
Blass, EM; Weller, A1
Chinn, C; Horita, A; Yabase, M1
Bechara, A; Martin, GM; van der Kooy, D1
Evans, RG; Olley, JE1
Berg, M; Johansson, B; Meyerson, BJ1
Dykstra, LA; Gmerek, DE; Winger, G; Woods, JH1
Dixon, R; Simpkins, JW; Smulkowski, M; Tuttle, R1
Brocklehurst, C; Devia, C; Moerschbaecher, JM1
Harty, GJ; Yaksh, TL1
Candeletti, S; Cavicchini, E; Ferri, S; Govoni, P; Marchini, M; Romualdi, P; Speroni, E1
Billington, CJ; Brown, DM; Gosnell, BA; Grace, M; Krahn, DD; Levine, AS; Morley, JE1
Ikebuchi, H; Kawanishi, T; Nagamatsu, K; Ohno, Y; Takanaka, A; Terao, T1
Portoghese, PS; Takahashi, M; Takemori, AE1
Stevens, CW; Yaksh, TL1
Ben-Eliyahu, S; Gale, RP; Liebeskind, JC; Martin, FC; Shavit, Y; Terman, GW; Weiner, H; Yirmiya, R1
Frey, HH1
Maier, SF1
Agren, H1
Galizio, M; Perone, M1
Duffy, P; Kalivas, PW1
Iakimova, K1
Adams, JU; France, CP; Woods, JH2
Kouchich, FJ; Panek, RW; Quock, RM; Rosenthal, MA1
Morgan, MJ; Pechnick, RN1
Arteau, C; Fujimoto, JM; Roerig, SC1
Borrell, J; Fuentes, JA; Naranjo, JR; Urdín, MC1
Gowans, GC; Grilly, DM1
Elsworth, JD; Redmond, DE; Roth, RH1
Risner, ME; Shannon, HE; Vaupel, DB1
Lira, SA; Phipps, DW; Sarkar, DK1
Abbott, P; Kristal, MB; Thompson, AC1
de Feo, G; Mazzanti, G; Piccinelli, D1
Ferreira, SH; Follenfant, RL; Smith, TW1
Cowan, A; Gmerek, DE; Woods, JH1
Cohen, AH; Inturrisi, CE; Yoburn, BC1
Holmes, LJ; Wise, RA1
Garrett, ER1
Adler-Graschinsky, E; Martínez, AE1
Pittock, F; Randall, J; Rodgers, RJ1
Girardot, MN; Holloway, FA1
Bapna, JS; Ramaswamy, S; Viswanathan, S1
Cowan, A; Gmerek, DE; Ryan, JP1
Dykstra, LA1
McLaughlin, PJ; Portoghese, PS; Takemori, AE; Zagon, IS1
Gmerek, DE; Woods, JH1
Chiang, CN; Foltz, RL; Gillespie, HK; Hollister, LE1
Fatherazi, S; Horita, A; Kazi, S; Lai, H1
Galbraith, JA; Mickley, GA; Stevens, KE1
Grishkat, HL; Kristal, MB; Thompson, AC1
Berg, M; Meyerson, BJ1
Jacobson, AE; Rice, KC; Sadée, W; Yu, VC1
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Li, M; McMillan, DE; Wessinger, WD1
Beresewicz, M; Kawalec, M; Kowalczyk, JE; Lipkowski, AW; Zablocka, B1
Kemppainen, H; Kiianmaa, K; Raivio, N; Suo-Yrjo, V1
Ciric, S; Johnson, FK; Setnik, B; Stauffer, J; Webster, LR1
Brewer, R; Cleveland, JM; Morris, D; Setnik, B; Webster, LR1
Fish, EW; Heilig, M; Krouse, MC; Malanga, CJ; Robinson, JE; Thorsell, A1
Gardner, AI; Hennessy, B; Sadleir, PH1
Bührer, C; Garten, L1
Diatchenko, L; Ding, F; Dokholyan, NV; Gauthier, J; Gibson, DG; Maixner, W; Serohijos, AW; Yin, S1
Goyal, R; Kumar, K; Mohan, A; Mudgal, A; Pasha, S1
Bath, B; Bilsky, E; Burkart, J; Dallaire, B; Magiera, D; Phelps, M; Sadee, W; Webster, L; Yancey-Wrona, J; Yang, X1
Adler, MW; Benamar, K; Brailoiu, E; Brailoiu, GC; Deliu, E; Dun, NJ; Hooper, R; Undieh, AS1
Castelli, M; Franchi, S; Lattuada, D; Moretti, S; Panerai, AE; Sacerdote, P; Scavullo, C1
Carstens, E; Carstens, MI; Davoodi, A; Spradley, JM1
Blair, HT; Halladay, LR1
Friedman, TC; Hamid, A; Kieffer, B; Lutfy, K; Marquez, P; Nguyen, AT1
Chen, Q; Lv, SY; Qin, YJ; Wang, NB; Yang, YJ1
Bobeck, EN; Haseman, RA; Hong, D; Ingram, SL; Morgan, MM1
Heintz, J; Kissling, KT; Mohassel, LR1
Dewey, WL; Gerk, PM; He, H; Kozak, P; Li, G; Mitra, P; Scoggins, KL; Selley, DE; Stevens, DL; Yuan, Y; Zhang, Y1
Casais e Silva, LL; Leite dos Santos, GG; Pereira Soares, MB; Villarreal, CF1
Altarifi, AA; Miller, LL; Negus, SS1
Bannwarth, B1
Arttamangkul, S; Cleary, DR; Heinricher, MM; Hough, LB; Nalwalk, JW; Phillips, RS1
Arout, C; Beijnen, JH; Dahan, A; den Hartigh, J; Kest, B; Mooren, RA; Swartjes, M; van de Wetering, K; Waxman, AR1
Johanek, LM; King, EW; Sato, KL; Sluka, KA1
Schaeffer, T1
Pappagallo, M; Sokolowska, M1
Bagetta, G; Katsuyama, S; Komatsu, T; Kuwahata, H; Mizoguchi, H; Nagaoka, K; Nakamura, H; Sakurada, S; Sakurada, T1
Chung, NN; Gibula-Bruzda, E; Izdebski, J; Kotlinska, JH; Schiller, PW; Witkowska, E1
Bailey, CP; Cordery, SF; Delgado-Charro, MB; Guy, RH; Husbands, SM; Ridzwan, IE; Taverner, A1
Dunlop, SA; Farid, WO; Hulse, GK; Krstew, EV; Lawrence, AJ; Tait, RJ1
Anselmi, L; Huynh, J; Sternini, C; Vegezzi, G1
Arttamangkul, S; Birdsong, WT; Cheng, K; Clark, MJ; Rice, KC; Traynor, JR; Williams, JT1
Ingram, SL; Lamberts, JT; Li, MH; Neubig, RR; Smith, CE; Traynor, JR1
Ise, Y; Katayama, S; Mori, T; Nagase, H; Suzuki, T1
Discala, JF; Gruber, RB; Lewis, SJ; May, WJ; McLaughlin, D; Palmer, LA; Young, AP1
Gonzales, RA; Howard, EC; Job, MO; Mangieri, RA; Schier, CJ; Valenta, JP1
Armstrong, SR; Beattie, DT; Campbell, CB; Hegde, SS; Long, DD; Richardson, CL; Tsuruda, PR; Vickery, RG1
Akbarian, R; Moezi, L; Niknahad, H; Shafaroodi, H1
Nelson, DE; Nickles, A; Su, X1
Bezawada, P; Coop, A; Healy, JR; Jones, JW; Kane, MA; MacKerell, AD; Matsumoto, RR; Shim, J1
Goli, V; Han, L; Setnik, B; Sommerville, K; Webster, L1
Anghel, A; Ferrini, MG; Friedman, TC; Liu, Y; Lutfy, K; Nie, Y; Nillni, EA; Paez Espinosa, EV; Stuart, RC1
Banks, ML; Bowers, MS; Carlezon, WA; Cheng, K; Leitl, MD; Negus, SS; Onvani, S; Rice, KC1
Bergeron, A; Dicaire, C; Furtado, M; Garofolo, F; Mess, JN1
Eastwood, EC; Phillips, TJ1
Pergolizzi, JV; Raffa, RB; Taylor, R1
Hamzah, AS; Kek, TL; Mansor, NS; Mohammat, MF; Salleh, MZ; Sani, MH; Shaameri, Z; Zakaria, ZA1
Chelnokova, O; Eikemo, M; Laeng, B; Leknes, S; Løseth, G; Maurud, H; Riegels, J; Willoch, F1
Awad, MM; Chakravorty, A; Cheung, JK; Choo, JM; Hiscox, TJ; Lyras, D; Rood, JI1
Amini, A; Asadi, S; Farbood, A; Zand, F1
Arout, CA; Caldwell, M; Kest, B; McCloskey, DP1
Dehpour, AR; Ejtemaei Mehr, S; Haj-Mirzaian, A; Kordjazy, N; Ostadhadi, S1
Cahill, CM; Olmstead, MC; Ong, EW; Xue, L1
Gao, MJ; Kao, JH; Law, PY; Loh, HH; Tao, PL; Yang, PP1
Coalson, DW; Wroblewski, K; Zacny, JP1
Bergman, J; Kangas, BD1
Bullmore, ET; Felici, A; Henderson, G; Kelly, E; Maltby, K; Mundell, SJ; Nathan, PJ; Roth, AL; Sava, A1
Jagla, C; Martus, P; Stein, C1
Clark, JD; Liang, DY; Sahbaie, P; Shi, XY; Sun, Y1
Carlezon, WA; Cheng, K; Leitl, MD; Negus, SS; Potter, DN; Rice, KC1
Chen, L; Li, YQ; Mei, XP; Wang, K; Wang, W; Yang, T; Zhang, FX; Zhu, C1
Carvalho, B; Nathan, E; Ng, L; Paech, M; Sia, A; Sng, B1
Kelsey, JE; Schierberl, KC; Verhaak, AM1
Bell, RL; Gonzales, CR; Hart, JC; Lowe, SL; McKinzie, DL; McKinzie, JH; Mitch, CH; Need, AB; Rorick-Kehn, LM; Statnick, MA; Stoltz, RR; Suico, JG; Tauscher-Wisniewski, S; Weller, MA; Witcher, JW; Wong, CJ1
Beaudry, H; Gendron, L; Morón, JA1
Indovina, P; Raffaeli, W1
Gibula-Bruzda, E; Izdebski, J; Kotlinska, JH; Marszalek-Grabska, M; Witkowska, E1
Ghanbari, A; Mahmoodi, M; Moradi, M; Raoofi, A1
Brokjaer, A; Christrup, LL; Dahan, A; Drewes, AM; Olesen, AE1
Dou, Y; Huang, W; Li, Q; Lin, Y; Shu, H; Wang, Z; Xiao, X; Ye, F1
Fernández-Guasti, A; González-Trujano, ME; Hernandez-Leon, A1
King, T; Navratilova, E; Okun, A; Porreca, F; Remeniuk, B; Sukhtankar, D; Xie, JY1
Arout, CA; Caldwell, M; Kest, B; Rossi, G1
Grace, PM; Jacobson, AE; Rice, KC; Selfridge, BR; Wang, X; Watkins, LR; Yin, H; Zhang, Y1
Lu, Z; Majumdar, S; Pan, YX; Pasternak, GW; Rossi, GC; Xu, J1
Farré-Albaladejo, M; Fernández-Nieva, Z; Gascón-Crespí, I; Hernández, RM; Igartua, M; Moreno-Vicente, R; Navarro, A; Pedraz, JL1
Hang, A; Liu, JG; Liu, Y; Shu, XH; Wang, Q; Wang, YJ; Zan, GY1
Goumon, Y; Khabbazi, S; Parat, MO1
Dolgin, E1
Alijanpour, S; Amini-Khoei, H; Amiri, S; Dehpour, AR; Gooshe, M; Haj-Mirzaian, A; Hassanipour, M; Mehr, SE; Rahimi-Balaei, M; Shirzadian, A1
Pixton, GC; Setnik, B; Webster, LR1
Akatsu, R; Horie, S; Kato, S; Matsumoto, K; Mori, T; Saito, S; Shibasaki, M; Suzuki, T; Tashima, K; Umemoto, H1
Barzin, J; Jafari-Nodoushan, M; Mobedi, H1
de Carvalho, CR; Takahashi, RN1
Fakhrzad, A; Khosravani, E; Moezi, L; Shafaroodi, H1
Fernández, SN; Fernández-Llamazares, C; González, R; López, J; López-Herce, J; Santiago, MJ; Urbano, J1
Grinnell, SG; Le Rouzic, V; Lu, Z; Majumdar, S; Marrone, GF; Pan, YX; Pasternak, GW; Rossi, GC; Xu, J1
Ling, Y; Oberdick, J; Phelps, MA; Sadee, W; Schilling, K; Yudovich, MS1
Aminian, A; Asadi Amoli, F; Dehpour, AR; Ejtemaei Mehr, S; Javadi, S; Moghaddas, P; Rahimian, R1
Dai, Q; Liu, FY; Liu, WW; Wang, JL; Wei, J; Yang, B; Zeng, P; Zhang, MM1
Bardo, MT; Beckmann, JS; Hofford, RS1
Ayala, M; Ellis, A; Falci, S; Favret, J; Grace, PM; Hutchinson, MR; Maier, SF; Rice, KC; Skarda, B; Springer, K; Watkins, LR; Wieseler, J1
Dehpour, AR; Haj-Mirzaian, A; Khaloo, P; Norouzi-Javidan, A; Ostadhadi, S; Sadeghi, B; Zolfagharie, S1
Chelnokova, O; Eikemo, M; Laeng, B; Leknes, S; Løseth, G; Willoch, F1
Eikemo, M; Gjerstad, J; Johnstone, T; Leknes, S; Løseth, GE; Willoch, F1
Aceves, AR; Aceves, M; Bancroft, EA; Hook, MA1
Chehrei, S; Falahi, M; Ghanbari, A; Ghiabi, HR; Kaviani, S; Moradi, M1
Barres, BA; Bohlen, CJ; Clark, JD; Corder, G; Dickinson, JR; Low, SA; Scherrer, G; Sotoudeh, C; Sypek, EI; Tawfik, VL; Wang, D1
Biele, G; Eikemo, M; Leknes, S; Thomsen, L; Willoch, F1
Al-Khrasani, M; Balogh, M; Benyhe, S; Erdei, AI; Fehér, Á; Fürst, S; Hosztafi, S; Király, K; Kocsis, D; Lackó, E; Noszál, B; Riba, P; Váradi, A; Zádor, F; Zádori, ZS1
da Luz, SC; Nogueira, CW; Pesarico, AP; Rosa, SG; Tagliapietra, CF1
Banks, ML; Cheng, K; Moerke, MJ; Negus, SS; Rice, KC1
Bach-Rojecky, L; Drinovac Vlah, V; Filipović, B; Lacković, Z1
Anant, K; Sader, S; Wu, C1
De Felice, M; Dodick, DW; Hernandez, PI; Nation, KM; Navratilova, E; Neugebauer, V; Porreca, F1
Chen, C; Johnson, T; Meng, J; Roy, S; Wang, F; Zhang, L1
Negus, SS; Sakloth, F1
Cutler, SJ; Hemby, SE; Leon, F; McCurdy, CR; McIntosh, S1
Akbarali, HI; Dewey, WL; Komla, E; Obeng, S; Selley, DE; Stevens, DL; Wang, H; Zhang, Y; Zheng, Y1
Kreek, MJ; Reed, B; Windisch, KA1
Deaver, DR; Kallman, MJ; Modlin, DL; Sgro, MP; Todtenkopf, MS1
Chai, JR; Dong, H; Huang, X; Liu, GY; Long, JD; Ma, Y; Wang, YH; Wang, YJ; Xiao, ZC; Xu, XJ; Ye, RF; Zan, GY1
An, J; Chen, C; Li, X; Lu, H; Tan, R; Wang, F; Wang, J; Wu, G; Zhao, X1
Pixton, GC; Setnik, B; Sommerville, KW; Webster, L1
Fanelli, A; Ghisi, D; Sorella, MC1
Giancola, JB; Keighron, JD; Lin, SC; Newman, AH; Scaglione, A; Tanda, G; Zanettini, C1
Banks, ML; Blough, BE; Faunce, KE; Grim, TW; Negus, SS; Obeng, S; Rice, KC; Schwienteck, KL; Zhang, Y1
Cattaneo, M; Cicero, TJ; Dart, RC; Mardekian, J; Mendoza, M; Park, PW; Polson, M; Roland, CL; Schnoll, SH; Webster, LR1
Heller, NM; Maher, DP; Walia, D1
Ashfaq, UA; Farhan, A; Humayun, F; Masoud, MS; Munir, A; Qasim, M; Rehman, M; Shah, M; Tariq, I1
Eikemo, M; Leknes, S; Løseth, GE1
Akbarabadi, A; Niknamfar, S; Nouri Zadeh-Tehrani, S; Rahimi-Movaghar, A; Sadat-Shirazi, MS; Zarrindast, MR1
Ishikawa, H; Sato, J; Shino, M; Suzuki, T; Tanaka, R1
Chen, ZF; Ginosar, Y; Hincker, A; Liu, XY; Yazdi, J1
Jilma, B; Schoergenhofer, C1
Angiolillo, DJ; Bass, TA; Been, L; Faz, G; Franchi, F; Hu, J; Kureti, M; Park, Y; Pineda, AM; Rivas Rios, J; Rollini, F; Soffer, D; Suryadevara, S; Yaranov, D; Zenni, MM1
Banks, ML; Blake, S; Bremer, PT; Negus, SS; Poklis, JL; Schwienteck, KL; Townsend, EA1
Bardo, MT; Beckmann, JS; Hammerslag, LR; Hofford, RS; Kang, Q; Kryscio, RJ1
Han, C; He, L; Lei, D; Li, S; Liu, L; Ma, T; Wen, S; Xie, S; Zhou, H1
Kunzler, NM; Nelson, LS; Wightman, RS1
Blasio, A; Cottone, P; DiLeo, A; Sabino, V; Valenza, M1
Ahlström, FHG; Blomqvist, KJ; Dudek, KA; Kalso, EA; Laitila, J; Lilius, TO; Mätlik, K; Rauhala, PV; Viisanen, H1
Annibale, P; Bock, A; Grushevskyi, EO; Heilemann, M; Isbilir, A; Karathanasis, C; Lohse, MJ; Möller, J; Osberg, B; Schütte, C; Sungkaworn, T; Sunkara, V1
Cunningham, CW; France, CP; Gerak, LR; Hu, Z; Mada, S; Maguire, DR; Minervini, V; Soyer, A1
Bäckström, P; Kiianmaa, K; Oinio, V; Piepponen, P; Raasmaja, A; Sundström, M; Uhari-Väänänen, J1
Akbarali, HI; Beardsley, PM; Komla, E; Moisa, LT; Mustafa, MA; Poklis, JL; Walentiny, DM1
Jin, Z; Kim, K; Zhan, CG; Zhang, CH; Zheng, F1
Bilbrey, JA; Felix, JS; McCurdy, CR; McMahon, LR; Wilkerson, JL1
Ballet, S; Bermudez, M; De Neve, J; Dumitrascuta, M; Spetea, M; Trovato, O; Wolber, G1
Asadi Rad, A; Dadfar, B; Rahimi, S; Rashid Shabkahi, A; Siahposht-Khachaki, A; Tavakolian, G1
Douros, A; Farhat, I; Lim, J; Panagiotoglou, D1
Daunert, S; Deo, S; Dikici, E; Peyravian, N; Sun, E; Toborek, M1
McKew, JC; Sadee, W1
Bergman, J; Chambers, DR; Goldberg, A; Imler, GH; Jacobson, AE; Luo, D; Nassehi, N; Paronis, CA; Prisinzano, TE; Rice, KC; Selley, DE; Shi, L; Sulima, A; Xie, B1
Ding, H; Kiguchi, N; Kishioka, S; Ko, MC; Mabry, KM1
Benéitez García, MC; Colmena Crespo, I; Díez-Orejas, RM; Gil-Alegre, ME; Girón Moreno, R; Goicoechea García, C; Martín Fontelles, MI; Sánchez-Robles, EM1
Arai, K; Ide, S; Ikeda, K; Iwase, N; Kojima, M; Taniko, K; Ushiyama, S1
Bassman, JR; Beardsley, PM; Hassanien, SH; Holt, MC; Iula, DM; Layle, NK; Stevens, DL; Varshneya, NB1
Chambers, DR; Jacobson, AE; Luo, D; Prisinzano, TE; Rice, KC; Sulima, A1
Chan, MH; Chen, HH; Chen, LC1

Reviews

28 review(s) available for naltrexone and morphine

ArticleYear
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
    Annual review of pharmacology and toxicology, 2000, Volume: 40

    Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic

2000
UDP-glucuronosyltransferases and clinical drug-drug interactions.
    Pharmacology & therapeutics, 2005, Volume: 106, Issue:1

    Topics: Clinical Trials as Topic; Drug Interactions; Enzyme Activation; Enzyme Induction; Glucuronides; Glucuronosyltransferase; Humans; Pharmaceutical Preparations; Pharmacogenetics; Polymorphism, Genetic

2005
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Drug discrimination studies.
    Drug and alcohol dependence, 1985, Volume: 14, Issue:3-4

    Topics: Analgesics, Opioid; Animals; Columbidae; Discrimination, Psychological; Dose-Response Relationship, Drug; Fentanyl; Generalization, Stimulus; Macaca mulatta; Morphine; Nalorphine; Naloxone; Naltrexone; Pentazocine; Phenazocine; Phencyclidine; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu

1985
Multiple endogenous opiate and non-opiate analgesia systems: evidence of their existence and clinical implications.
    Annals of the New York Academy of Sciences, 1986, Volume: 467

    Topics: Acupuncture Therapy; Analgesia; Animals; Cholecystokinin; Conditioning, Classical; Desipramine; Dimethyl Sulfoxide; Drug Interactions; Electroshock; Endorphins; Enkephalin, Leucine; Mecamylamine; Morphine; N-Methylscopolamine; Naloxone; Naltrexone; Norepinephrine; Proglumide; Rats; Receptors, Cell Surface; Receptors, Cholecystokinin; Scopolamine; Scopolamine Derivatives; Serotonin; Spinal Cord

1986
Stressor controllability and stress-induced analgesia.
    Annals of the New York Academy of Sciences, 1986, Volume: 467

    Topics: Analgesia; Animals; Avoidance Learning; Electroshock; Injections, Spinal; Morphine; Naloxone; Naltrexone; Pain; Rats; Restraint, Physical; Sensory Thresholds; Stress, Physiological; Time Factors

1986
Clonidine treatment of the opiate withdrawal syndrome. A review of clinical trials of a theory.
    Acta psychiatrica Scandinavica. Supplementum, 1986, Volume: 327

    Topics: Adrenergic Fibers; Animals; Antidepressive Agents, Tricyclic; Brain; Clinical Trials as Topic; Clonidine; Dextropropoxyphene; Drug Therapy, Combination; Heroin Dependence; Humans; Locus Coeruleus; Methadone; Morphine; Naltrexone; Narcotics; Norepinephrine; Rats; Substance Withdrawal Syndrome

1986
The physiology of opiate hedonic effects and the role of opioids in motivated behavior.
    Advances in alcohol & substance abuse, 1984,Spring, Volume: 3, Issue:3

    Topics: Animals; Conditioning, Operant; Electric Stimulation; Electroshock; Emotions; Endorphins; Feeding Behavior; Humans; Hypothalamus; Medial Forebrain Bundle; Morphine; Motivation; Naloxone; Naltrexone; Narcotics; Rats; Reward; Self Stimulation; Substance-Related Disorders

1984
Limitations on the antagonistic actions of opioid antagonists.
    Federation proceedings, 1982, Volume: 41, Issue:7

    Topics: Animals; Behavior, Animal; Columbidae; Conditioning, Operant; Cyclazocine; Macaca mulatta; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Saimiri

1982
Brain opioids and mother-infant social motivation.
    Acta paediatrica (Oslo, Norway : 1992). Supplement, 1994, Volume: 397

    Topics: Animals; Biofeedback, Psychology; Female; Humans; Infant; Infant, Newborn; Maternal Behavior; Morphine; Mother-Child Relations; Motivation; Naltrexone; Object Attachment; Social Behavior

1994
Neuropeptides and alcohol addiction in monkeys.
    EXS, 1994, Volume: 71

    Topics: Alcoholism; Animals; beta-Endorphin; Ethanol; Humans; Macaca mulatta; Male; Morphine; Naltrexone; Neuropeptides; Rats; Reinforcement, Psychology; Self Administration

1994
Morphine-induced modulation of immune status: evidence for opioid receptor mediation and compartment specificity.
    Advances in experimental medicine and biology, 1993, Volume: 335

    Topics: Humans; Immunity; Morphine; Naltrexone; Receptors, Opioid

1993
Opioid antagonists in the treatment of opioid-induced constipation and pruritus.
    The Annals of pharmacotherapy, 2001, Volume: 35, Issue:1

    Topics: Clinical Trials as Topic; Constipation; Humans; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pruritus; Quaternary Ammonium Compounds

2001
A review of the potential role of methylnaltrexone in opioid bowel dysfunction.
    American journal of surgery, 2001, Volume: 182, Issue:5A Suppl

    Topics: Analgesics, Opioid; Animals; Constipation; Dose-Response Relationship, Drug; Gastrointestinal Motility; Gastrointestinal Transit; Humans; Intestines; Morphine; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Receptors, Opioid

2001
The preclinical development of Medisorb Naltrexone, a once a month long acting injection, for the treatment of alcohol dependence.
    Frontiers in bioscience : a journal and virtual library, 2005, Jan-01, Volume: 10

    Topics: Alcoholism; Animals; Chemistry, Pharmaceutical; Delayed-Action Preparations; Drug Design; Drug Industry; Humans; Injections; Morphine; Naltrexone; Polymers; Rats; Receptors, Opioid, mu

2005
A morphine/naltrexone combination (Embeda) for pain.
    The Medical letter on drugs and therapeutics, 2010, Mar-22, Volume: 52, Issue:1334

    Topics: Analgesics, Opioid; Chronic Disease; Delayed-Action Preparations; Drug Approval; Drug Combinations; Humans; Morphine; Naltrexone; Narcotic Antagonists; Osteoarthritis; Pain; Randomized Controlled Trials as Topic; United States; United States Food and Drug Administration

2010
Morphine/naltrexone.
    CNS drugs, 2010, Volume: 24, Issue:6

    Topics: Adult; Delayed-Action Preparations; Drug Combinations; Drug Interactions; Humans; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Pain; Receptors, Opioid, mu

2010
Opioid formulations designed to resist/deter abuse.
    Drugs, 2010, Sep-10, Volume: 70, Issue:13

    Topics: Analgesics, Opioid; Delayed-Action Preparations; Drug Combinations; Humans; Morphine; Naltrexone; Niacin; Opioid-Related Disorders; Oxycodone; Pain; United States

2010
Morphine sulfate and naltrexone hydrochloride extended release capsules for the management of chronic, moderate-to-severe pain, while reducing morphine-induced subjective effects upon tampering by crushing.
    Expert opinion on pharmacotherapy, 2011, Volume: 12, Issue:7

    Topics: Analgesics, Opioid; Delayed-Action Preparations; Drug Combinations; Euphoria; Female; Humans; Male; Morphine; Naltrexone; Pain

2011
Will abuse-deterrent formulations of opioid analgesics be successful in achieving their purpose?
    Drugs, 2012, Sep-10, Volume: 72, Issue:13

    Topics: Analgesics, Opioid; Chemistry, Pharmaceutical; Drug Combinations; Drug Discovery; Drug Overdose; Drug Prescriptions; Humans; Morphine; Naltrexone; Opioid-Related Disorders; Pain

2012
Abuse-deterrent formulations, an evolving technology against the abuse and misuse of opioid analgesics.
    Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2012, Volume: 8, Issue:4

    Topics: Analgesics, Opioid; Buprenorphine; Chemistry, Pharmaceutical; Dextroamphetamine; Humans; Lisdexamfetamine Dimesylate; Morphine; Naltrexone; Opioid-Related Disorders; Pain; Prescription Drug Misuse; United States; United States Food and Drug Administration

2012
Sequestered naltrexone in sustained release morphine or oxycodone - a way to inhibit illicit use?
    Expert opinion on drug safety, 2014, Volume: 13, Issue:2

    Topics: Analgesics, Opioid; Delayed-Action Preparations; Humans; Illicit Drugs; Morphine; Naltrexone; Opioid-Related Disorders; Oxycodone

2014
Abuse-deterrent opioid formulations.
    The Medical letter on drugs and therapeutics, 2015, Aug-31, Volume: 57, Issue:1476

    Topics: Analgesics, Opioid; Animals; Chemistry, Pharmaceutical; Delayed-Action Preparations; Drug Combinations; Humans; Morphine; Naltrexone; Opioid-Related Disorders

2015
Safety profile of extended-release morphine sulfate with sequestered naltrexone hydrochloride in older patients: pooled analysis of three clinical trials.
    Current medical research and opinion, 2016, Volume: 32, Issue:3

    Topics: Aged; Analgesics, Opioid; Chemistry, Pharmaceutical; Delayed-Action Preparations; Drug Combinations; Female; Humans; Male; Middle Aged; Morphine; Naltrexone; Narcotic Antagonists; Randomized Controlled Trials as Topic

2016
Morphine sulfate abuse-deterrent formulations for the treatment of chronic pain.
    Expert review of clinical pharmacology, 2018, Volume: 11, Issue:12

    Topics: Abuse-Deterrent Formulations; Analgesics, Opioid; Chronic Pain; Delayed-Action Preparations; Humans; Morphine; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Prescription Drug Misuse

2018
Opioid Withdrawal Precipitated by Long-Acting Antagonists.
    The Journal of emergency medicine, 2020, Volume: 58, Issue:2

    Topics: Drug Combinations; Emergency Service, Hospital; Humans; Morphine; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Substance Withdrawal Syndrome

2020
Relative effectiveness of medications for opioid-related disorders: A systematic review and network meta-analysis of randomized controlled trials.
    PloS one, 2022, Volume: 17, Issue:3

    Topics: Analgesics, Opioid; Buprenorphine; Humans; Methadone; Morphine; Naltrexone; Network Meta-Analysis; Opioid-Related Disorders; Randomized Controlled Trials as Topic

2022
Ligand-Free Signaling of G-Protein-Coupled Receptors: Relevance to μ Opioid Receptors in Analgesia and Addiction.
    Molecules (Basel, Switzerland), 2022, Sep-08, Volume: 27, Issue:18

    Topics: Analgesia; Analgesics, Opioid; Humans; Ligands; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Pain; Receptors, Opioid, mu

2022

Trials

42 trial(s) available for naltrexone and morphine

ArticleYear
Human pharmacology and abuse potential of nalmefene.
    Clinical pharmacology and therapeutics, 1991, Volume: 49, Issue:3

    Topics: Adult; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Male; Morphine; Naltrexone; Narcotic Antagonists; Substance-Related Disorders

1991
Prophylactic oral naltrexone with epidural morphine: effect on adverse reactions and ventilatory responses to carbon dioxide.
    Anesthesiology, 1990, Volume: 72, Issue:2

    Topics: Administration, Oral; Adult; Analgesia, Epidural; Anesthesia, Obstetrical; Carbon Dioxide; Cesarean Section; Double-Blind Method; Female; Humans; Morphine; Naltrexone; Pain, Postoperative; Pregnancy; Prospective Studies; Randomized Controlled Trials as Topic; Respiration Disorders

1990
Prophylactic oral naltrexone with intrathecal morphine for cesarean section: effects on adverse reactions and analgesia.
    Anesthesia and analgesia, 1990, Volume: 71, Issue:4

    Topics: Administration, Oral; Adult; Cesarean Section; Double-Blind Method; Female; Humans; Injections, Spinal; Morphine; Naltrexone; Nausea; Pain, Postoperative; Pregnancy; Pruritus; Randomized Controlled Trials as Topic; Sleep

1990
Nontolerance to the opioid antagonism of naltrexone.
    Biological psychiatry, 1985, Volume: 20, Issue:1

    Topics: Adult; Arousal; Clinical Trials as Topic; Dose-Response Relationship, Drug; Double-Blind Method; Drug Tolerance; Euphoria; Female; Heart Rate; Heroin Dependence; Humans; Male; Middle Aged; Morphine; Naloxone; Naltrexone; Receptors, Opioid

1985
Antagonism of morphine-induced respiratory depression with nalmefene.
    British journal of anaesthesia, 1988, Volume: 61, Issue:3

    Topics: Adult; Carbon Dioxide; Depression, Chemical; Humans; Male; Middle Aged; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Partial Pressure; Respiration; Time Factors

1988
Clonidine treatment of the opiate withdrawal syndrome. A review of clinical trials of a theory.
    Acta psychiatrica Scandinavica. Supplementum, 1986, Volume: 327

    Topics: Adrenergic Fibers; Animals; Antidepressive Agents, Tricyclic; Brain; Clinical Trials as Topic; Clonidine; Dextropropoxyphene; Drug Therapy, Combination; Heroin Dependence; Humans; Locus Coeruleus; Methadone; Morphine; Naltrexone; Narcotics; Norepinephrine; Rats; Substance Withdrawal Syndrome

1986
A bioequivalence study of oral controlled-release morphine using naltrexone blockade.
    Journal of clinical pharmacology, 1995, Volume: 35, Issue:5

    Topics: Administration, Oral; Adult; Cross-Over Studies; Delayed-Action Preparations; Humans; Male; Morphine; Naltrexone; Therapeutic Equivalency

1995
Efficacy of methylnaltrexone versus naloxone for reversal of morphine-induced depression of hypoxic ventilatory response.
    Anesthesia and analgesia, 1994, Volume: 78, Issue:4

    Topics: Adult; Double-Blind Method; Humans; Hypoxia; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Respiration

1994
Opioid antagonist adjuncts to epidural morphine for postcesarean analgesia: maternal outcomes.
    Anesthesia and analgesia, 1993, Volume: 77, Issue:5

    Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Butorphanol; Cesarean Section; Female; Humans; Morphine; Nalbuphine; Naltrexone; Narcotic Antagonists; Pain, Postoperative; Pregnancy; Prospective Studies

1993
Relative bioavailability of controlled-release oral morphine sulfate during naltrexone blockade.
    International journal of clinical pharmacology and therapeutics, 1995, Volume: 33, Issue:9

    Topics: Adult; Biological Availability; Blood Pressure; Cross-Over Studies; Delayed-Action Preparations; Half-Life; Humans; Male; Middle Aged; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Pulse; Respiration; Single-Blind Method

1995
Methylnaltrexone prevents morphine-induced delay in oral-cecal transit time without affecting analgesia: a double-blind randomized placebo-controlled trial.
    Clinical pharmacology and therapeutics, 1996, Volume: 59, Issue:4

    Topics: Adolescent; Adult; Analgesics, Opioid; Breath Tests; Cold Temperature; Double-Blind Method; Female; Gastrointestinal Transit; Humans; Hydrogen; Injections, Intravenous; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain Measurement; Pressure; Quaternary Ammonium Compounds

1996
The safety and efficacy of oral methylnaltrexone in preventing morphine-induced delay in oral-cecal transit time.
    Clinical pharmacology and therapeutics, 1997, Volume: 61, Issue:4

    Topics: Administration, Oral; Adult; Analgesics, Opioid; Breath Tests; Dose-Response Relationship, Drug; Female; Gastrointestinal Transit; Humans; Hydrogen; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Quaternary Ammonium Compounds; Reference Values; Single-Blind Method

1997
Efficacy of orally administered methylnaltrexone in decreasing subjective effects after intravenous morphine.
    Drug and alcohol dependence, 1998, Oct-01, Volume: 52, Issue:2

    Topics: Administration, Oral; Adult; Affect; Arousal; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Infusions, Intravenous; Male; Morphine; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Treatment Outcome

1998
Effects of prophylactic nalmefene on the incidence of morphine-related side effects in patients receiving intravenous patient-controlled analgesia.
    Anesthesiology, 1999, Volume: 90, Issue:4

    Topics: Adult; Analgesia, Patient-Controlled; Analgesics, Opioid; Dose-Response Relationship, Drug; Female; Humans; Middle Aged; Morphine; Naltrexone; Narcotic Antagonists; Nausea; Postoperative Complications; Pruritus; Vomiting

1999
Effects of enteric-coated methylnaltrexone in preventing opioid-induced delay in oral-cecal transit time.
    Clinical pharmacology and therapeutics, 2000, Volume: 67, Issue:4

    Topics: Administration, Oral; Adult; Breath Tests; Double-Blind Method; Female; Gastrointestinal Agents; Gastrointestinal Transit; Humans; Lactulose; Male; Morphine; Naltrexone; Narcotic Antagonists; Pilot Projects; Quaternary Ammonium Compounds; Tablets, Enteric-Coated; Time Factors

2000
Nalmefene: blockade of intravenous morphine challenge effects in opioid abusing humans.
    Drug and alcohol dependence, 2000, Jul-01, Volume: 60, Issue:1

    Topics: Adult; Analysis of Variance; Cross-Over Studies; Double-Blind Method; Humans; Injections, Intravenous; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Pupil

2000
Effects of subcutaneous methylnaltrexone on morphine-induced peripherally mediated side effects: a double-blind randomized placebo-controlled trial.
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 300, Issue:1

    Topics: Administration, Oral; Adult; Analgesics, Opioid; Breath Tests; Double-Blind Method; Female; Gastrointestinal Transit; Humans; Injections, Intravenous; Injections, Subcutaneous; Male; Morphine; Naltrexone; Narcotic Antagonists; Peripheral Nervous System; Quaternary Ammonium Compounds

2002
The impact of nalmefene on side effects due to intrathecal morphine at cesarean section.
    AANA journal, 2001, Volume: 69, Issue:3

    Topics: Adult; Analgesia, Epidural; Analgesics, Opioid; Cesarean Section; Double-Blind Method; Female; Humans; Morphine; Naltrexone; Narcotic Antagonists; Pain, Postoperative; Postoperative Complications; Postoperative Nausea and Vomiting; Pregnancy; Pruritus; Statistics, Nonparametric; Survival Analysis; Time Factors

2001
Pharmacokinetics of the opioid antagonist N-methylnaltrexone and evaluation of its effects on gastrointestinal tract function in horses treated or not treated with morphine.
    American journal of veterinary research, 2006, Volume: 67, Issue:6

    Topics: Analgesics, Opioid; Animals; Drug Interactions; Gastrointestinal Tract; Gastrointestinal Transit; Horses; Male; Morphine; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds

2006
Subjective effects and safety of whole and tampered morphine sulfate and naltrexone hydrochloride (ALO-01) extended-release capsules versus morphine solution and placebo in experienced non-dependent opioid users: a randomized, double-blind, placebo-contro
    Clinical drug investigation, 2009, Volume: 29, Issue:12

    Topics: Adult; Analgesics, Opioid; Capsules; Cross-Over Studies; Delayed-Action Preparations; Double-Blind Method; Drug Combinations; Euphoria; Female; Humans; Male; Middle Aged; Morphine; Naltrexone; Narcotic Antagonists; Pharmaceutical Solutions; Pupil; Time Factors; Young Adult

2009
ALO-01 (morphine sulfate and naltrexone hydrochloride) extended-release capsules in the treatment of chronic pain of osteoarthritis of the hip or knee: pharmacokinetics, efficacy, and safety.
    The journal of pain, 2010, Volume: 11, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Chronic Disease; Cross-Over Studies; Double-Blind Method; Drug Combinations; Female; Humans; Illicit Drugs; Male; Middle Aged; Morphine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Osteoarthritis, Hip; Osteoarthritis, Knee; Pain Measurement; Treatment Outcome

2010
Relative oral bioavailability of morphine and naltrexone derived from crushed morphine sulfate and naltrexone hydrochloride extended-release capsules versus intact product and versus naltrexone solution: a single-dose, randomized-sequence, open-label, thr
    Clinical therapeutics, 2010, Volume: 32, Issue:6

    Topics: Administration, Oral; Adult; Area Under Curve; Biological Availability; Cross-Over Studies; Delayed-Action Preparations; Drug Combinations; Female; Humans; Male; Middle Aged; Morphine; Naltrexone; Narcotic Antagonists; Narcotics

2010
Morphine sulfate and naltrexone hydrochloride extended release capsules in patients with chronic osteoarthritis pain.
    Postgraduate medicine, 2010, Volume: 122, Issue:4

    Topics: Acetaminophen; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Capsules; Chronic Disease; Delayed-Action Preparations; Double-Blind Method; Female; Humans; Male; Middle Aged; Morphine; Naltrexone; Narcotic Antagonists; Osteoarthritis; Pain; Pain Measurement; Placebos; Treatment Outcome

2010
The relative bioavailability of morphine sulfate and naltrexone hydrochloride extended release capsules (EMBEDA®) and an extended release morphine sulfate capsule formulation (KADIAN®) in healthy adults under fasting conditions.
    American journal of therapeutics, 2011, Volume: 18, Issue:1

    Topics: Adult; Analgesics, Opioid; Area Under Curve; Biological Availability; Biotransformation; Capsules; Chemistry, Pharmaceutical; Cross-Over Studies; Delayed-Action Preparations; Double-Blind Method; Drug Combinations; Fasting; Female; Half-Life; Humans; Male; Middle Aged; Morphine; Naltrexone; Therapeutic Equivalency; Young Adult

2011
Food effects on the pharmacokinetics of morphine sulfate and naltrexone hydrochloride extended release capsules.
    Advances in therapy, 2010, Volume: 27, Issue:11

    Topics: Adult; Area Under Curve; Biological Availability; Cross-Over Studies; Delayed-Action Preparations; Dietary Fats; Drug-Related Side Effects and Adverse Reactions; Fasting; Feeding Behavior; Female; Food-Drug Interactions; Humans; Male; Middle Aged; Morphine; Naltrexone

2010
Long-term safety and efficacy of morphine sulfate and naltrexone hydrochloride extended release capsules, a novel formulation containing morphine and sequestered naltrexone, in patients with chronic, moderate to severe pain.
    Journal of pain and symptom management, 2010, Volume: 40, Issue:5

    Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Chronic Disease; Constipation; Delayed-Action Preparations; Drug Combinations; Female; Humans; Male; Middle Aged; Morphine; Naltrexone; Narcotic Antagonists; Nausea; Pain; Pain Measurement; Treatment Outcome

2010
Does adding low doses of oral naltrexone to morphine alter the subsequent opioid requirements and side effects in trauma patients?
    The American journal of emergency medicine, 2012, Volume: 30, Issue:1

    Topics: Administration, Oral; Adult; Analgesia; Analgesics, Opioid; Double-Blind Method; Drug Therapy, Combination; Extremities; Female; Humans; Male; Morphine; Naltrexone; Narcotic Antagonists; Wounds and Injuries

2012
Effects of alcohol on the pharmacokinetics of morphine sulfate and naltrexone hydrochloride extended release capsules.
    Journal of clinical pharmacology, 2012, Volume: 52, Issue:5

    Topics: Adult; Alcohol Drinking; Analgesics, Opioid; Analysis of Variance; Area Under Curve; Capsules; Cross-Over Studies; Delayed-Action Preparations; Drug Combinations; Drug Interactions; Ethanol; Female; Humans; Male; Metabolic Clearance Rate; Models, Biological; Morphine; Naltrexone; Narcotic Antagonists; Young Adult

2012
Impact of intravenous naltrexone on intravenous morphine-induced high, drug liking, and euphoric effects in experienced, nondependent male opioid users.
    Drugs in R&D, 2011, Sep-01, Volume: 11, Issue:3

    Topics: Analgesics, Opioid; Cross-Over Studies; Double-Blind Method; Drug Combinations; Drug Interactions; Euphoria; Humans; Injections, Intravenous; Male; Morphine; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Pain; Pain Measurement; Substance-Related Disorders; Young Adult

2011
Opioid titration and conversion in patients receiving morphine sulfate and naltrexone hydrochloride extended release capsules.
    Postgraduate medicine, 2011, Volume: 123, Issue:5

    Topics: Adolescent; Adult; Aged; Capsules; Delayed-Action Preparations; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Morphine; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Young Adult

2011
6β-naltrexol, a peripherally selective opioid antagonist that inhibits morphine-induced slowing of gastrointestinal transit: an exploratory study.
    Pain medicine (Malden, Mass.), 2011, Volume: 12, Issue:12

    Topics: Adult; Animals; Breath Tests; Constipation; Cross-Over Studies; Double-Blind Method; Gastrointestinal Transit; Humans; Male; Miosis; Morphine; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Pilot Projects; Placebos; Young Adult

2011
Assessment of pharmacodynamic effects following oral administration of crushed morphine sulfate and naltrexone hydrochloride extended-release capsules compared with crushed morphine sulfate controlled-release tablets and placebo in nondependent recreation
    Pain medicine (Malden, Mass.), 2013, Volume: 14, Issue:8

    Topics: Analgesics, Opioid; Area Under Curve; Body Mass Index; Cross-Over Studies; Delayed-Action Preparations; Discrimination, Psychological; Double-Blind Method; Endpoint Determination; Ethnicity; Female; Follow-Up Studies; Humans; Male; Morphine; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Pupil; Tablets; Young Adult

2013
Rewards of beauty: the opioid system mediates social motivation in humans.
    Molecular psychiatry, 2014, Volume: 19, Issue:7

    Topics: Analgesics, Opioid; Beauty; Cross-Over Studies; Double-Blind Method; Face; Humans; Male; Morphine; Motivation; Naltrexone; Narcotic Antagonists; Photic Stimulation; Receptors, Opioid, mu; Reward

2014
The effect of methylnaltrexone on the side effects of intrathecal morphine after orthopedic surgery under spinal anesthesia.
    Pain practice : the official journal of World Institute of Pain, 2015, Volume: 15, Issue:4

    Topics: Adult; Analgesics, Opioid; Anesthesia, Spinal; Double-Blind Method; Female; Humans; Male; Middle Aged; Morphine; Naltrexone; Narcotic Antagonists; Orthopedic Procedures; Pain, Postoperative; Postoperative Complications; Quaternary Ammonium Compounds; Young Adult

2015
Methylnaltrexone: its pharmacological effects alone and effects on morphine in healthy volunteers.
    Psychopharmacology, 2015, Volume: 232, Issue:1

    Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Double-Blind Method; Female; Healthy Volunteers; Heart Rate; Humans; Infusions, Intravenous; Male; Morphine; Naltrexone; Narcotic Antagonists; Pupil; Quaternary Ammonium Compounds; Receptors, Opioid, mu; Treatment Outcome; Young Adult

2015
Peripheral opioid receptor blockade increases postoperative morphine demands--a randomized, double-blind, placebo-controlled trial.
    Pain, 2014, Volume: 155, Issue:10

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesia, Patient-Controlled; Analgesics, Opioid; Arthroplasty, Replacement, Knee; Double-Blind Method; Female; Humans; Male; Middle Aged; Morphine; Naltrexone; Narcotic Antagonists; Pain Measurement; Pain, Postoperative; Quaternary Ammonium Compounds; Young Adult

2014
Methylnaltrexone to prevent intrathecal morphine-induced pruritus after Caesarean delivery: a multicentre, randomized clinical trial.
    British journal of anaesthesia, 2015, Volume: 114, Issue:3

    Topics: Adult; Analgesia, Obstetrical; Analgesics, Opioid; Anesthesia, Spinal; Australia; Cesarean Section; Female; Humans; Middle Aged; Morphine; Naltrexone; Narcotic Antagonists; Postoperative Complications; Pregnancy; Pruritus; Quaternary Ammonium Compounds; Singapore; Treatment Outcome; United States; Young Adult

2015
Determining pharmacological selectivity of the kappa opioid receptor antagonist LY2456302 using pupillometry as a translational biomarker in rat and human.
    The international journal of neuropsychopharmacology, 2014, Oct-31, Volume: 18, Issue:2

    Topics: Adolescent; Adult; Animals; Benzamides; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Fentanyl; Humans; Male; Middle Aged; Miosis; Morphine; Mydriasis; Naltrexone; Narcotic Antagonists; Narcotics; Pupil; Pyrrolidines; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Young Adult

2014
The effects of morphine and methylnaltrexone on gastrointestinal pain in healthy male participants.
    Neurogastroenterology and motility, 2015, Volume: 27, Issue:5

    Topics: Administration, Rectal; Adult; Analgesics, Opioid; Cross-Over Studies; Double-Blind Method; Healthy Volunteers; Humans; Injections, Subcutaneous; Male; Middle Aged; Morphine; Muscle, Skeletal; Naltrexone; Narcotic Antagonists; Pupil; Quaternary Ammonium Compounds; Rectum; Skin; Visceral Pain; Young Adult

2015
Opioid Modulation of Value-Based Decision-Making in Healthy Humans.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2017, Volume: 42, Issue:9

    Topics: Adult; Analgesics, Opioid; Computer Simulation; Cross-Over Studies; Decision Making; Double-Blind Method; Humans; Models, Neurological; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Reaction Time; Receptors, Opioid, mu; Reward; Young Adult

2017
Effects of opioid receptor stimulation and blockade on touch pleasantness: a double-blind randomised trial.
    Social cognitive and affective neuroscience, 2019, 05-17, Volume: 14, Issue:4

    Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Double-Blind Method; Emotions; Humans; Male; Morphine; Naltrexone; Narcotic Antagonists; Reward; Touch; Touch Perception; Young Adult

2019
Effects of Methylnaltrexone on Ticagrelor-Induced Antiplatelet Effects in Coronary Artery Disease Patients Treated With Morphine.
    JACC. Cardiovascular interventions, 2019, 08-26, Volume: 12, Issue:16

    Topics: Administration, Intravenous; Administration, Oral; Aged; Analgesics, Opioid; Blood Platelets; Cell Adhesion Molecules; Coronary Artery Disease; Cross-Over Studies; Double-Blind Method; Drug Interactions; Female; Florida; Gastric Emptying; Gastrointestinal Absorption; Humans; Male; Microfilament Proteins; Middle Aged; Morphine; Naltrexone; Narcotic Antagonists; Phosphoproteins; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Quaternary Ammonium Compounds; Ticagrelor; Treatment Outcome

2019

Other Studies

1201 other study(ies) available for naltrexone and morphine

ArticleYear
Quantum chemical studies of N-substituent variation in the oxymorphone series of opiate narcotics.
    Journal of medicinal chemistry, 1978, Volume: 21, Issue:1

    Topics: Analgesics, Opioid; Animals; Hydromorphone; In Vitro Techniques; Mice; Molecular Conformation; Oxymorphone; Quantum Theory; Rats; Structure-Activity Relationship; Swine; Thermodynamics

1978
Structure-activity relationships for drugs binding to the agonist and antagonist states of the primary morphine receptor.
    Journal of medicinal chemistry, 1988, Volume: 31, Issue:3

    Topics: Algorithms; Animals; Kinetics; Models, Molecular; Narcotic Antagonists; Narcotics; Protein Conformation; Rats; Receptors, Opioid; Structure-Activity Relationship

1988
A novel opioid receptor site directed alkylating agent with irreversible narcotic antagonistic and reversible agonistic activities.
    Journal of medicinal chemistry, 1980, Volume: 23, Issue:3

    Topics: Alkylating Agents; Animals; Guinea Pigs; In Vitro Techniques; Morphinans; Muscle Contraction; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Narcotics; Oxymorphone; Receptors, Opioid

1980
Allylprodine analogues as receptor probes. Evidence that phenolic and nonphenolic ligands interact with different subsites on identical opioid receptors.
    Journal of medicinal chemistry, 1981, Volume: 24, Issue:7

    Topics: Animals; Chemical Phenomena; Chemistry, Physical; Guinea Pigs; Ileum; In Vitro Techniques; Ligands; Mice; Morphine; Muscle Contraction; Muscle, Smooth; Narcotic Antagonists; Phenols; Piperidines; Reaction Time; Receptors, Opioid; Structure-Activity Relationship

1981
Different receptor sites mediate opioid agonism and antagonism.
    Journal of medicinal chemistry, 1983, Volume: 26, Issue:10

    Topics: Animals; Binding Sites; Kinetics; Naltrexone; Narcotic Antagonists; Narcotics; Receptors, Opioid; Structure-Activity Relationship

1983
Some 14 beta-substituted analogues of N-(cyclopropylmethyl)normorphine.
    Journal of medicinal chemistry, 1981, Volume: 24, Issue:2

    Topics: Animals; Chemical Phenomena; Chemistry; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Morphine; Morphine Derivatives; Muscle, Smooth; Vas Deferens

1981
Analgesic narcotic antagonists. 8. 7 alpha-Alkyl-4,5 alpha-epoxymorphinan-6-ones.
    Journal of medicinal chemistry, 1981, Volume: 24, Issue:12

    Topics: Analgesics; Animals; Chemical Phenomena; Chemistry; Codeine; Hydrocodone; In Vitro Techniques; Mice; Narcotic Antagonists; Rats; Reaction Time

1981
Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors.
    Molecular pharmacology, 1994, Volume: 45, Issue:2

    Topics: Analgesics; Animals; Binding Sites; Cell Line; CHO Cells; Cloning, Molecular; Cricetinae; Ligands; PC12 Cells; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Software

1994
Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications.
    NIDA research monograph, 1998, Volume: 178

    Topics: Animals; Aorta, Thoracic; Cocaine; Cyclic AMP; Electric Stimulation; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Mice; Muscle, Smooth; Opioid-Related Disorders; Rats; Receptors, Dopamine; Receptors, Opioid; Receptors, Serotonin; Substance-Related Disorders

1998
Predicting blood-brain barrier permeation from three-dimensional molecular structure.
    Journal of medicinal chemistry, 2000, Jun-01, Volume: 43, Issue:11

    Topics: Blood-Brain Barrier; Databases, Factual; Models, Chemical; Molecular Conformation; Multivariate Analysis; Permeability; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
3-Carboxamido analogues of morphine and naltrexone. synthesis and opioid receptor binding properties.
    Bioorganic & medicinal chemistry letters, 2001, Jul-09, Volume: 11, Issue:13

    Topics: Amides; Morphine Derivatives; Naltrexone; Protein Binding; Receptors, Opioid

2001
Identification of opioid ligands possessing mixed micro agonist/delta antagonist activity among pyridomorphinans derived from naloxone, oxymorphone, and hydromorphone [correction of hydropmorphone].
    Journal of medicinal chemistry, 2004, Mar-11, Volume: 47, Issue:6

    Topics: Analgesics; Animals; Binding Sites; Brain; Drug Tolerance; Electric Stimulation; Guinea Pigs; Hydromorphone; Ileum; In Vitro Techniques; Ligands; Male; Mice; Mice, Inbred ICR; Morphinans; Muscle Contraction; Muscle, Smooth; Naloxone; Oxymorphone; Pyridines; Radioligand Assay; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Vas Deferens

2004
Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure.
    Journal of pharmaceutical sciences, 2005, Volume: 94, Issue:7

    Topics: Algorithms; Animals; Dogs; Haplorhini; Humans; Pharmaceutical Preparations; Pharmacokinetics; Rats; Species Specificity; Tissue Distribution

2005
Structural determinants of opioid activity in derivatives of 14-aminomorphinones: effect of substitution in the aromatic ring of cinnamoylaminomorphinones and codeinones.
    Journal of medicinal chemistry, 2006, Aug-24, Volume: 49, Issue:17

    Topics: Cinnamates; Codeine; Drug Design; Ligands; Molecular Structure; Morphine Derivatives; Receptors, Opioid, mu; Stereoisomerism; Structure-Activity Relationship

2006
Naloxone acts as a potent analgesic in transgenic mouse models of sickle cell anemia.
    Proceedings of the National Academy of Sciences of the United States of America, 2007, Apr-03, Volume: 104, Issue:14

    Topics: Analgesics; Analgesics, Opioid; Anemia, Sickle Cell; Animals; Chemokine CCL5; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Drug Synergism; Injections, Intraventricular; Injections, Spinal; Injections, Subcutaneous; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Knockout; Mice, Transgenic; Morphine; Naloxone; Pain; Pain Measurement; Receptors, CCR5

2007
Hologram QSAR model for the prediction of human oral bioavailability.
    Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24

    Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2007
Cinnamoyl derivatives of 7alpha-aminomethyl-6,14-endo-ethanotetrahydrothebaine and 7alpha-aminomethyl-6,14-endo-ethanotetrahydrooripavine and related opioid ligands.
    Journal of medicinal chemistry, 2007, Oct-18, Volume: 50, Issue:21

    Topics: Analgesics; Animals; Binding, Competitive; CHO Cells; Cinnamates; Cricetinae; Cricetulus; Humans; Ligands; Mice; Molecular Conformation; Narcotic Antagonists; Radioligand Assay; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship; Thebaine

2007
The influence of esters and carboxylic acids as the N-substituent of opioids. Part 1: Benzomorphans.
    Bioorganic & medicinal chemistry, 2008, Jan-15, Volume: 16, Issue:2

    Topics: Analgesics, Opioid; Benzomorphans; Carboxylic Acids; Esters; Molecular Structure; Stereoisomerism; Structure-Activity Relationship

2008
Endomorphin-2 with a beta-turn backbone constraint retains the potent micro-opioid receptor agonist properties.
    Journal of medicinal chemistry, 2008, Jan-10, Volume: 51, Issue:1

    Topics: Magnetic Resonance Spectroscopy; Models, Molecular; Oligopeptides; Protein Structure, Secondary; Receptors, Opioid, mu; Solutions; Stereoisomerism; Structure-Activity Relationship

2008
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
Syntheses and opioid receptor binding properties of carboxamido-substituted opioids.
    Bioorganic & medicinal chemistry letters, 2009, Jan-01, Volume: 19, Issue:1

    Topics: Amides; Analgesics, Opioid; Humans; Protein Binding; Receptors, Opioid; Structure-Activity Relationship; Tramadol

2009
Design, synthesis, and biological evaluation of 6alpha- and 6beta-N-heterocyclic substituted naltrexamine derivatives as mu opioid receptor selective antagonists.
    Journal of medicinal chemistry, 2009, Mar-12, Volume: 52, Issue:5

    Topics: Amino Acid Sequence; Analgesics; Analgesics, Opioid; Animals; Binding Sites; Binding, Competitive; CHO Cells; Cricetinae; Cricetulus; Drug Design; Ligands; Models, Molecular; Molecular Sequence Data; Morphinans; Morphine; Naltrexone; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sequence Alignment; Structure-Activity Relationship

2009
14 beta-O-cinnamoylnaltrexone and related dihydrocodeinones are mu opioid receptor partial agonists with predominant antagonist activity.
    Journal of medicinal chemistry, 2009, Mar-26, Volume: 52, Issue:6

    Topics: Hydrocodone; Magnetic Resonance Spectroscopy; Naltrexone; Receptors, Opioid, mu; Spectrometry, Mass, Electrospray Ionization

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Experimental solubility profiling of marketed CNS drugs, exploring solubility limit of CNS discovery candidate.
    Bioorganic & medicinal chemistry letters, 2010, Dec-15, Volume: 20, Issue:24

    Topics: Central Nervous System Agents; Drug Evaluation, Preclinical; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Solubility

2010
Generation of novel radiolabeled opiates through site-selective iodination.
    Bioorganic & medicinal chemistry letters, 2011, Jul-01, Volume: 21, Issue:13

    Topics: Animals; Binding Sites; Binding, Competitive; CHO Cells; Cricetinae; Cricetulus; Humans; Iodine Radioisotopes; Molecular Structure; Neurotransmitter Agents; Oxymorphone; Radioligand Assay; Receptors, Opioid

2011
Synthesis of novel triplet drugs with 1,3,5-trioxazatriquinane skeletons and their pharmacologies. 1: Synthesis of triplet drugs with morphinan skeletons.
    Bioorganic & medicinal chemistry letters, 2011, Jul-01, Volume: 21, Issue:13

    Topics: Analgesics; Bridged-Ring Compounds; Dose-Response Relationship, Drug; Molecular Structure; Morphinans; Naltrexone; Receptors, Opioid, mu

2011
Synthesis of new opioid derivatives with a propellane skeleton and their pharmacology: part 1.
    Bioorganic & medicinal chemistry letters, 2011, Jul-01, Volume: 21, Issue:13

    Topics: Analgesics, Opioid; Animals; Bridged-Ring Compounds; Cells, Cultured; Mice; Molecular Structure; Protein Binding; Receptors, Opioid, kappa; Structure-Activity Relationship; Substrate Specificity

2011
Synthesis of novel triplet drugs with 1,3,5-trioxazatriquinane skeletons and their pharmacologies. Part 2: Synthesis of novel triplet drugs with the epoxymethano structure (capped homotriplet).
    Bioorganic & medicinal chemistry letters, 2011, Oct-15, Volume: 21, Issue:20

    Topics: Analgesics, Opioid; Animals; Bridged-Ring Compounds; Mice; Models, Molecular; Nitriles; Nociception; Nociceptive Pain; Pain Measurement; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sesquiterpenes; Tosyl Compounds

2011
Synthesis and evaluation of aryl-naloxamide opiate analgesics targeting truncated exon 11-associated μ opioid receptor (MOR-1) splice variants.
    Journal of medicinal chemistry, 2012, Jul-26, Volume: 55, Issue:14

    Topics: Amides; Analgesics; Animals; Behavior, Animal; Brain; Cell Line; Chemistry Techniques, Synthetic; Exons; Male; Mice; Opiate Alkaloids; Protein Isoforms; Protein Structure, Tertiary; Receptors, Opioid, mu; Structure-Activity Relationship

2012
Design, synthesis, and biological evaluation of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4'-pyridyl)carboxamido]morphinan derivatives as peripheral selective μ opioid receptor Agents.
    Journal of medicinal chemistry, 2012, Nov-26, Volume: 55, Issue:22

    Topics: Analgesics; Animals; Caco-2 Cells; Drug Design; Gastrointestinal Motility; Humans; Male; Mice; Models, Molecular; Molecular Structure; Morphinans; Morphine Derivatives; Narcotic Antagonists; Radioligand Assay; Receptors, Opioid, mu; Structure-Activity Relationship; Tissue Distribution

2012
Design, syntheses, and pharmacological characterization of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(isoquinoline-3'-carboxamido)morphinan analogues as opioid receptor ligands.
    Bioorganic & medicinal chemistry, 2015, Apr-15, Volume: 23, Issue:8

    Topics: Animals; CHO Cells; Cricetulus; Drug Design; Humans; Isoquinolines; Ligands; Mice; Molecular Dynamics Simulation; Morphinans; Morphine Dependence; Narcotic Antagonists; Receptors, Opioid, mu; Structure-Activity Relationship

2015
Opioids as Substrates and Inhibitors of the Genetically Highly Variable Organic Cation Transporter OCT1.
    Journal of medicinal chemistry, 2019, 11-14, Volume: 62, Issue:21

    Topics: Analgesics, Opioid; HEK293 Cells; Humans; Inhibitory Concentration 50; Models, Molecular; Organic Cation Transporter 1; Permeability; Protein Conformation

2019
Behavioral effects of narcotic analgesics administered alone or in combination with narcotic antagonists.
    Proceedings of the Western Pharmacology Society, 1976, Volume: 19

    Topics: Analgesics, Opioid; Animals; Avoidance Learning; Behavior, Animal; Drug Interactions; Electroshock; Haplorhini; Macaca fascicularis; Methadone; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Time Factors

1976
Development of Chronomers for narcotic antagonists.
    National Institute on Drug Abuse research monograph series, 1975, Issue:4

    Topics: Animals; Biodegradation, Environmental; Drug Implants; Hydrogen-Ion Concentration; Kinetics; Morphine; Naloxone; Naltrexone; Polymers; Rats; Reaction Time

1975
An improved long-acting delivery system for narcotic antagonists.
    The Journal of pharmacy and pharmacology, 1978, Volume: 30, Issue:5

    Topics: Animals; Cholesterol; Delayed-Action Preparations; Drug Implants; Male; Morphine; Naltrexone; Narcotic Antagonists; Placebos; Rats; Stearates; Time Factors

1978
Opiate-receptor mediated changes in monoamine synthesis in rat brain.
    The Journal of pharmacy and pharmacology, 1978, Volume: 30, Issue:10

    Topics: Animals; Behavior, Animal; Biogenic Amines; Brain; Catalepsy; Endorphins; Humans; Injections, Intraventricular; Male; Morphine; Naloxone; Naltrexone; Rats; Receptors, Opioid; Time Factors

1978
GABA turnover as a tool to explore the function of GABA-ergic synapses: physiological and pharmacological studies.
    Advances in experimental medicine and biology, 1979, Volume: 123

    Topics: Animals; Brain; Carbon Isotopes; Electric Stimulation; gamma-Aminobutyric Acid; Homovanillic Acid; Kinetics; Morphine; Naltrexone; Neurotransmitter Agents; Rats; Substantia Nigra; Synapses; Tissue Distribution

1979
Chloroxymorphamine, and opioid receptor site-directed alkylating agent having narcotic agonist activity.
    Science (New York, N.Y.), 1979, Apr-20, Volume: 204, Issue:4390

    Topics: Alkylating Agents; Animals; Chlorambucil; Dose-Response Relationship, Drug; Drug Synergism; Guinea Pigs; Hydromorphone; In Vitro Techniques; Morphine; Naloxone; Naltrexone; Nitrogen Mustard Compounds; Norepinephrine; Oxymorphone; Phenoxybenzamine; Receptors, Opioid

1979
Morphine as a discriminative cue in gerbils: drug generalization and antagonism.
    Psychopharmacology, 1978, Jul-19, Volume: 58, Issue:3

    Topics: Animals; Cues; Discrimination, Psychological; Drug Antagonism; Generalization, Stimulus; Gerbillinae; Male; Morphine; Naltrexone; Stereoisomerism

1978
Prevention by naltrexone of tolerance to the rate-decreasing effects of morphine on schedule-controlled responding in the pigeon.
    Psychopharmacology, 1979, May-08, Volume: 63, Issue:1

    Topics: Animals; Columbidae; Conditioning, Operant; Drug Tolerance; Male; Morphine; Naloxone; Naltrexone; Reinforcement Schedule; Time Factors

1979
Naltrexone-induced hypothermia in the rat.
    European journal of pharmacology, 1976, Volume: 39, Issue:2

    Topics: Animals; Body Temperature Regulation; Dose-Response Relationship, Drug; Humans; Hypothermia; Morphine; Naloxone; Naltrexone; Placebos; Rats; Receptors, Opioid; Substance Withdrawal Syndrome; Substance-Related Disorders

1976
Endogenous opiate receptor ligand: electrically induced release in the guinea pig ileum.
    Science (New York, N.Y.), 1977, Jan-28, Volume: 195, Issue:4276

    Topics: Electric Stimulation; Ileum; Ligands; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Nerve Tissue Proteins; Neuromuscular Junction; Peptides; Receptors, Opioid; Stereoisomerism

1977
On the mechanism of the decrease in cerebellar cyclic GMP content elicited by opiate receptor agonists.
    Naunyn-Schmiedeberg's archives of pharmacology, 1977, Volume: 296, Issue:2

    Topics: Analgesics; Animals; Apomorphine; Cerebellum; Corpus Striatum; Cyclic GMP; Dextromoramide; Ethanolamines; Injections; Male; Morphine; Naltrexone; Narcotics; Pyridines; Rats; Reaction Time; Receptors, Opioid; Time Factors

1977
Behavioural dissociation of the enkephalinergic systems of nucleus accumbens and nucleus caudatus.
    Neuropharmacology, 1977, Volume: 16, Issue:5

    Topics: Animals; Brain; Caudate Nucleus; Enkephalins; Globus Pallidus; Male; Morphine; Naloxone; Naltrexone; Olfactory Bulb; Oligopeptides; Rats; Receptors, Opioid; Stereotaxic Techniques

1977
Opioid peptides and opiates differ in receptor selectivity.
    Psychoneuroendocrinology, 1977, Volume: 2, Issue:1

    Topics: Animals; Brain; Dextrorphan; Endorphins; Enkephalins; Isomerism; Levorphanol; Methadone; Morphine; Naloxone; Naltrexone; Rats; Receptors, Opioid

1977
Behavioral and electrophysiological effects of peptides related to lipotropin (beta-LPH).
    The Journal of pharmacology and experimental therapeutics, 1978, Volume: 204, Issue:3

    Topics: Adrenocorticotropic Hormone; Analgesics; Animals; Avoidance Learning; Behavior, Animal; beta-Lipotropin; Drug Interactions; Electroshock; Endorphins; Hippocampus; Male; Morphine; Motor Activity; Naltrexone; Rats; Rats, Inbred Strains; Reaction Time

1978
Interaction of ligands with the opiate receptors of brain membranes: regulation by ions and nucleotides.
    Proceedings of the National Academy of Sciences of the United States of America, 1978, Volume: 75, Issue:4

    Topics: Animals; Brain; Enkephalins; Etorphine; Guanylyl Imidodiphosphate; Ligands; Male; Manganese; Morphine; Morphine Derivatives; Naltrexone; Rats; Receptors, Opioid; Ribonucleotides; Sodium

1978
6beta-[N,N-Bis(2-chloroethyl)amino]-17-(cyclopropylmethyl)-4,5alpha-epoxy-3,14-dihydroxymorphinan(chlornaltrexamine) a potent opioid receptor alkylating agent with ultralong narcotic antagonist actitivty.
    Journal of medicinal chemistry, 1978, Volume: 21, Issue:7

    Topics: Alkylating Agents; Analgesia; Binding, Competitive; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Nitrogen Mustard Compounds; Receptors, Opioid

1978
Opiate receptor agonists as modulators of gamma-aminobutyric acid turnover in the nucleus caudatus, globus pallidus and substantia nigra of the rat.
    The Journal of pharmacology and experimental therapeutics, 1978, Volume: 207, Issue:3

    Topics: Animals; Catalepsy; Caudate Nucleus; Endorphins; gamma-Aminobutyric Acid; Globus Pallidus; Humans; Male; Morphine; Muscimol; Naltrexone; Rats; Receptors, Opioid; Substantia Nigra

1978
Synthesis and pharmacologic characterization of an alkylating analogue (chlornaltrexamine) of naltrexone with ultralong-lasting narcotic antagonist properties.
    Journal of medicinal chemistry, 1979, Volume: 22, Issue:2

    Topics: Alkylating Agents; Analgesics; Animals; Humans; In Vitro Techniques; Male; Mice; Molecular Conformation; Morphine; Morphine Dependence; Naloxone; Naltrexone; Narcotic Antagonists; Nitrogen Mustard Compounds; Rats; Receptors, Opioid; Time Factors

1979
Differential sensitivity to morphine-induced analgesia and motor activity in two inbred strains of mice: behavioral and biochemical correlations.
    The Journal of pharmacology and experimental therapeutics, 1979, Volume: 209, Issue:1

    Topics: Adenylyl Cyclases; Analgesics; Animals; Brain Chemistry; Cerebellum; Corpus Striatum; Cyclic AMP; Cyclic GMP; Dopamine; Haloperidol; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Morphine; Motor Activity; Naltrexone; Species Specificity

1979
Endogenous opioids participate in the regulation of the hypothalamus-pituitary-luteinizing hormone axis and testosterone's negative feedback control of luteinizing hormone.
    Endocrinology, 1979, Volume: 104, Issue:5

    Topics: Animals; Dose-Response Relationship, Drug; Endorphins; Gonadotropin-Releasing Hormone; Hypothalamo-Hypophyseal System; Luteinizing Hormone; Male; Morphine; Naloxone; Naltrexone; Pituitary Gland; Rats; Testosterone

1979
Continuous intravenous naltrexone effects on morphine self-administration in rhesus monkeys.
    The Journal of pharmacology and experimental therapeutics, 1978, Volume: 204, Issue:2

    Topics: Animals; Dose-Response Relationship, Drug; Haplorhini; Infusions, Parenteral; Macaca mulatta; Morphine; Naloxone; Naltrexone; Self Administration; Time Factors

1978
Nitrous oxide stimulation of locomotor activity: evidence for an opiate-like behavioral effect.
    The Journal of pharmacology and experimental therapeutics, 1979, Volume: 209, Issue:2

    Topics: Adaptation, Psychological; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Male; Mice; Morphine; Motor Activity; Naloxone; Naltrexone; Narcotics; Nitrous Oxide

1979
Effects of morphine and beta-endorphin on basal and elevated plasma levels of alpha-MSH and vasopressin.
    Life sciences, 1979, Feb-12, Volume: 24, Issue:7

    Topics: Animals; Endorphins; Injections, Intraperitoneal; Injections, Intraventricular; Male; Melanocyte-Stimulating Hormones; Morphine; Naltrexone; Rats; Vasopressins

1979
Evidence supporting lack of discriminative stimulus properties of a combination of naltrexone and morphine.
    Pharmacology, biochemistry, and behavior, 1979, Volume: 10, Issue:4

    Topics: Animals; Discrimination, Psychological; Drug Interactions; Generalization, Stimulus; Gerbillinae; Male; Morphine; Naloxone; Naltrexone

1979
Acute effects of opiate agonists, partial agonists and antagonists on brain monoamines in the rat.
    Archives internationales de pharmacodynamie et de therapie, 1979, Volume: 238, Issue:1

    Topics: Animals; Behavior, Animal; Biogenic Amines; Brain Chemistry; Cyclazocine; Dextrorphan; Female; Levallorphan; Morphine; Nalorphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pentazocine; Rats

1979
Studies of the possible role of brain endorphins in pentobarbital anesthesia and toxicity in mice.
    Anesthesiology, 1979, Volume: 51, Issue:5

    Topics: Animals; Brain; Endorphins; Enkephalins; Leucine; Male; Mice; Morphine; Naloxone; Naltrexone; Pentobarbital; Phenylalanine

1979
Behavioral effects of perinatal naltrexone exposure: a preliminary investigation.
    Pharmacology, biochemistry, and behavior, 1979, Volume: 11 Suppl

    Topics: Analgesics; Animals; Animals, Newborn; Behavior, Animal; Conditioning, Operant; Electroshock; Emotions; Female; Morphine; Motor Activity; Naloxone; Naltrexone; Pregnancy; Rats; Reaction Time

1979
The effects of naltrexone on the development of physical dependence on morphine.
    European journal of pharmacology, 1978, Aug-01, Volume: 50, Issue:3

    Topics: Animals; Behavior, Animal; Body Temperature; Brain; Drug Implants; Humans; Male; Mice; Morphine; Morphine Dependence; Naloxone; Naltrexone; Time Factors

1978
Discriminative stimulus effects of naltrexone in the morphine-dependent rat.
    The Journal of pharmacology and experimental therapeutics, 1979, Volume: 211, Issue:3

    Topics: Animals; Generalization, Stimulus; Humans; Male; Morphine; Morphine Dependence; Naloxone; Naltrexone; Narcotic Antagonists; Prejudice; Rats; Substance Withdrawal Syndrome; Time Factors

1979
Central and peripheral actions of morphine on intestinal transit.
    The Journal of pharmacology and experimental therapeutics, 1978, Volume: 205, Issue:3

    Topics: Animals; Central Nervous System; Gastrointestinal Motility; Injections, Intraventricular; Injections, Subcutaneous; Male; Morphine; Naltrexone; Rats; Vagotomy

1978
Plasma corticosteroid levels in rats maintained on a long-acting naltrexone delivery system.
    Research communications in chemical pathology and pharmacology, 1978, Volume: 20, Issue:1

    Topics: Adrenal Cortex Hormones; Animals; Drug Implants; Male; Morphine; Naloxone; Naltrexone; Rats; Reaction Time; Time Factors

1978
Stereospecific aversive property of narcotic antagonists in morphine-free rats.
    Life sciences, 1978, May-15, Volume: 22, Issue:19

    Topics: Animals; Avoidance Learning; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Stereoisomerism; Structure-Activity Relationship

1978
Naltrexone, morphine and cocaine interactions in mice and rats.
    The Journal of pharmacology and experimental therapeutics, 1978, Volume: 206, Issue:2

    Topics: Animals; Cocaine; Drug Interactions; Lethal Dose 50; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Reaction Time; Reflex

1978
Midbrain raphe mediation of the narcotic blockade of ovulation.
    Brain research, 1978, Oct-27, Volume: 155, Issue:2

    Topics: Animals; Brain Stem; Female; Luteinizing Hormone; Mesencephalon; Methadone; Morphine; Naltrexone; Ovulation; Raphe Nuclei; Rats

1978
Behavioral effects of chronic narcotic antagonist administration of infant rats.
    Neuropharmacology, 1978, Volume: 17, Issue:8

    Topics: Animals; Animals, Newborn; Behavior, Animal; Body Weight; Male; Morphine; Naltrexone; Narcotic Antagonists; Rats; Reaction Time

1978
Effects of repeated injections of naltrexone on antagonism of rate decreases by morphine in the pigeon.
    Pharmacology, biochemistry, and behavior, 1978, Volume: 9, Issue:2

    Topics: Animals; Behavior, Animal; Columbidae; Conditioning, Operant; Male; Morphine; Naloxone; Naltrexone; Time Factors

1978
Genotype dependent response of morphine and methionine-enkephalin on the electrically induced contractions of the mouse vas deferens.
    Naunyn-Schmiedeberg's archives of pharmacology, 1978, Volume: 305, Issue:1

    Topics: Animals; Electric Stimulation; Endorphins; Enkephalins; Genotype; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Morphine; Muscle Contraction; Muscle, Smooth; Naltrexone; Vas Deferens

1978
Discriminative effects of morphine in the pigeon.
    Pharmacology, biochemistry, and behavior, 1978, Volume: 9, Issue:4

    Topics: Animals; Columbidae; Dextrorphan; Discrimination, Psychological; Generalization, Psychological; Humans; Levorphanol; Morphine; Naloxone; Naltrexone; Time Factors

1978
Effects of opiates on the discriminative stimulus properties of dopamine agonists.
    Pharmacology, biochemistry, and behavior, 1978, Volume: 9, Issue:4

    Topics: Amphetamine; Animals; Apomorphine; Discrimination, Psychological; Dopamine; Haloperidol; Male; Morphine; Naltrexone; Narcotics; Pentazocine; Rats; Time Factors

1978
On the regulation of gamma-aminobutyric acid neurons in caudatus, pallidus and nigra: effects of opioids and dopamine agonists.
    The Journal of pharmacology and experimental therapeutics, 1979, Volume: 208, Issue:2

    Topics: Animals; Apomorphine; Brain; Caudate Nucleus; Corpus Striatum; Decerebrate State; Dopamine; Endorphins; gamma-Aminobutyric Acid; Globus Pallidus; Male; Morphine; Naltrexone; Narcotics; Neurons; Rats; Substantia Nigra

1979
Development of polylactic/glycolic acid delivery systems for use in treatment of narcotic addiction.
    National Institute on Drug Abuse research monograph series, 1976, Issue:4

    Topics: Animals; Drug Implants; Foreign-Body Reaction; Lactates; Male; Mice; Morphine; Naloxone; Naltrexone; Polyglycolic Acid; Polymers; Reaction Time; Time Factors

1976
Assessment of CNS drug activity in rhesus monkeys by analysis of the EEG.
    Federation proceedings, 1976, Volume: 35, Issue:11

    Topics: Amobarbital; Animals; Brain; Clorazepate Dipotassium; Codeine; Computers; Electroencephalography; Glutethimide; Haplorhini; Macaca mulatta; Morphine; Nalbuphine; Naloxone; Naltrexone

1976
[Precipitation and prevention of abstinence in acutely morphinized rats and mice: comparisons between naloxone, naltrexone, and diprenorphine (author's transl)].
    Psychopharmacology, 1976, Aug-26, Volume: 49, Issue:1

    Topics: Animals; Diprenorphine; Humans; Male; Mice; Morphinans; Morphine; Morphine Dependence; Naloxone; Naltrexone; Rats; Substance Withdrawal Syndrome; Time Factors

1976
Blockade of the discriminative effects of morphine in the rat by naltrexone and naloxone.
    Psychopharmacology, 1976, Nov-10, Volume: 50, Issue:2

    Topics: Administration, Oral; Animals; Cues; Discrimination, Psychological; Dose-Response Relationship, Drug; Injections, Subcutaneous; Male; Morphine; Naloxone; Naltrexone; Rats; Time Factors

1976
Testing of drug delivery systems for use in the treatment of narcotic addiction.
    National Institute on Drug Abuse research monograph series, 1975, Issue:4

    Topics: Animals; Blood Proteins; Dogs; Drug Implants; Guinea Pigs; Haplorhini; Humans; Kinetics; Mice; Morphine; Naloxone; Naltrexone; Protein Binding; Rats; Reaction Time; Species Specificity; Substance-Related Disorders

1975
Evaluation of narcotic and narcotic antagonist interactions in primates.
    Annals of the New York Academy of Sciences, 1976, Volume: 281

    Topics: Animals; Cyclazocine; Dextroamphetamine; Diazepam; Drug Interactions; Ethanol; Female; Haplorhini; Humans; Macaca mulatta; Male; Methadone; Methadyl Acetate; Morphine; Morphine Dependence; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Phenytoin; Secobarbital; Self Administration

1976
Constant rate infusion of deuterated phosphorylcholine to measure the effects of morphine on acetylcholine turnover rate in specific nuclei of rat brain.
    Neuropharmacology, 1977, Volume: 16, Issue:1

    Topics: Acetylcholine; Amygdala; Animals; Brain; Cerebral Cortex; Choline; Hippocampus; Kinetics; Male; Medulla Oblongata; Mesencephalon; Morphine; Naltrexone; Olfactory Bulb; Phosphorylcholine; Rats; Substantia Nigra; Time Factors

1977
Stereochemical studies on medicinal agents. 23. Synthesis and biological evaluation of 6-amino derivatives of naloxone and naltrexone.
    Journal of medicinal chemistry, 1977, Volume: 20, Issue:8

    Topics: Amination; Analgesics; Animals; Binding, Competitive; In Vitro Techniques; Male; Mice; Morphine; Naloxone; Naltrexone; Stereoisomerism

1977
Inhibition of acetylcholine turnover in rat hippocampus by intraseptal injections of beta-endorphin and morphine.
    Naunyn-Schmiedeberg's archives of pharmacology, 1977, Volume: 299, Issue:2

    Topics: Acetylcholine; Analgesia; Animals; Brain; Cerebral Cortex; Choline; Corpus Striatum; Depression, Chemical; Endorphins; Hippocampus; Injections; Male; Morphine; Naltrexone; Rats; Reaction Time

1977
Effects of acute and chronic morphine and narcotic antagonists on brain energy metabolism.
    Life sciences, 1977, Nov-15, Volume: 21, Issue:10

    Topics: Animals; Brain; Citrates; Energy Metabolism; Glucose; Malates; Male; Mice; Morphine; Naloxone; Naltrexone; Pyruvates

1977
The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog.
    The Journal of pharmacology and experimental therapeutics, 1976, Volume: 197, Issue:3

    Topics: Animals; Apomorphine; Cyclazocine; Cyclopropanes; Dextropropoxyphene; Dogs; Ethylketocyclazocine; Humans; Morphinans; Morphine; Morphine Dependence; Nalorphine; Naltrexone; Phenazocine; Spinal Cord

1976
Reinstatement of precipitated narcotic withdrawal hypothermia in the rat.
    Life sciences, 1976, Jun-01, Volume: 18, Issue:11

    Topics: Animals; Body Temperature; Female; Humans; Morphine; Naloxone; Naltrexone; Rats; Substance Withdrawal Syndrome; Substance-Related Disorders

1976
The structure-action relationship and kinetics of some naloxone and naltrexone derivatives.
    Pharmacology, 1976, Volume: 14, Issue:1

    Topics: Animals; Cyclazocine; Guinea Pigs; Ileum; Kinetics; Morphine; Morphine Derivatives; Muscle Contraction; Naloxone; Naltrexone; Narcotic Antagonists; Structure-Activity Relationship; Time Factors

1976
Long-acting narcotic antagonist complexes.
    National Institute on Drug Abuse research monograph series, 1976, Issue:4

    Topics: Animals; Brain; Diprenorphine; Methadone; Mice; Morphine; Naltrexone; Narcotic Antagonists; Reaction Time; Time Factors

1976
Sustained release of naltrexone from glyceride implants.
    National Institute on Drug Abuse research monograph series, 1976, Issue:4

    Topics: Animals; Delayed-Action Preparations; Drug Implants; Glycerides; Male; Mice; Morphine; Naloxone; Naltrexone; Reaction Time; Time Factors

1976
Use of synthetic polypeptides in the preparation of biodegradable delivery vehicles for narcotic antagonists.
    National Institute on Drug Abuse research monograph series, 1976, Issue:4

    Topics: Animals; Biodegradation, Environmental; Drug Implants; Mice; Morphine; Naltrexone; Narcotic Antagonists; Peptides; Reaction Time; Time Factors

1976
Development of Chronomers tm for narcotic antagonists.
    National Institute on Drug Abuse research monograph series, 1976, Issue:4

    Topics: Animals; Biodegradation, Environmental; Drug Implants; Injections, Subcutaneous; Kinetics; Mice; Morphine; Naltrexone; Narcotic Antagonists; Polymers; Rats; Reaction Time

1976
Morphine-naloxone interaction in the central cholinergic system: the influence of subcortical lesioning and electrical stimulation.
    British journal of pharmacology, 1976, Volume: 58, Issue:1

    Topics: Acetylcholine; Animals; Brain; Cerebral Cortex; Drug Interactions; Electric Stimulation; In Vitro Techniques; Morphine; Naloxone; Naltrexone; Parasympathetic Nervous System; Rats; Time Factors

1976
Nitrous oxide "analgesia": resemblance to opiate action.
    Science (New York, N.Y.), 1976, Nov-26, Volume: 194, Issue:4268

    Topics: Analgesia; Animals; Drug Tolerance; Mice; Morphine; Naloxone; Naltrexone; Nitrous Oxide

1976
Ethanol preference in the hamster: effects of morphine sulfate and naltrexone, a long-acting morphine antagonist.
    Proceedings of the Western Pharmacology Society, 1976, Volume: 19

    Topics: Alcohol Drinking; Animals; Choice Behavior; Cricetinae; Decision Making; Dextrorphan; Levorphanol; Morphine; Naloxone; Naltrexone; Time Factors

1976
Psychopathology and mood during heroin use: acute vs chronic effects.
    Archives of general psychiatry, 1976, Volume: 33, Issue:12

    Topics: Acute Disease; Adult; Chronic Disease; Dose-Response Relationship, Drug; Drug Therapy, Combination; Emotions; Euphoria; Heroin; Heroin Dependence; Humans; Male; Methadone; Morphine; Motor Activity; Naloxone; Naltrexone; Psychopathology

1976
Correlation between analgesia and the decrease of acetylcholine turnover rate in cortex and hippocampus elicited by morphine, meperidine, viminol R2 and azidomorphine.
    The Journal of pharmacology and experimental therapeutics, 1976, Volume: 199, Issue:3

    Topics: Acetylcholine; Analgesia; Animals; Cerebral Cortex; Corpus Striatum; Depression, Chemical; Ethanolamines; Hippocampus; Kinetics; Male; Meperidine; Morphine; Morphine Derivatives; Naltrexone; Rats

1976
Interactions of narcotics, narcotic antagonists, and ethanol during acute, chronic, and withdrawal states.
    Annals of the New York Academy of Sciences, 1976, Volume: 281

    Topics: Alcohol Drinking; Animals; Animals, Newborn; Dextrorphan; Drug Interactions; Ethanol; Humans; Levorphanol; Male; Methadone; Methadyl Acetate; Mice; Mice, Inbred C57BL; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors

1976
Comparative in vivo distribution of opiate agonists and antagonists by means of double isotope techniques.
    Life sciences, 1975, Oct-10, Volume: 17, Issue:7

    Topics: Animals; Autoradiography; Blood-Brain Barrier; Brain; Carbon Radioisotopes; Dose-Response Relationship, Drug; Liver; Male; Morphine; Naloxone; Naltrexone; Rats; Time Factors; Tritium

1975
Acetylcholine storage and its stabilization by morphine.
    Research communications in chemical pathology and pharmacology, 1975, Volume: 12, Issue:3

    Topics: Acetylcholine; Adenosine Triphosphate; Animals; Chemical Phenomena; Chemistry; In Vitro Techniques; Kinetics; Magnetic Resonance Spectroscopy; Morphine; Naloxone; Naltrexone; Sodium Chloride; Spectrometry, Fluorescence; Synaptosomes

1975
Clinical experience with naltrexone.
    The American journal of drug and alcohol abuse, 1975, Volume: 2, Issue:3-4

    Topics: Administration, Oral; Adult; Female; Heroin Dependence; Hospitalization; Humans; Male; Methadone; Middle Aged; Morphine; Naloxone; Naltrexone; Outpatient Clinics, Hospital; Patient Dropouts; Placebos; Time Factors

1975
Long-acting narcotic antagonist complexes.
    National Institute on Drug Abuse research monograph series, 1975, Issue:4

    Topics: Aluminum; Animals; Brain; Buffers; Chemistry, Pharmaceutical; Delayed-Action Preparations; Diprenorphine; Drug Stability; Methadone; Mice; Morphine; Naltrexone; Narcotic Antagonists; Reaction Time; Zinc

1975
Sustained release of naltrexone from glyceride implants.
    National Institute on Drug Abuse research monograph series, 1975, Issue:4

    Topics: Animals; Biodegradation, Environmental; Chemistry, Pharmaceutical; Drug Implants; Glycerides; Histocompatibility; Mice; Morphine; Naloxone; Naltrexone; Reaction Time; Time Factors

1975
Use of synthetic polypeptides in the preparation of biodegradable delivery vehicles for narcotic antagonists.
    National Institute on Drug Abuse research monograph series, 1975, Issue:4

    Topics: Animals; Biodegradation, Environmental; Drug Implants; Glutamates; Leucine; Mice; Morphine; Naloxone; Naltrexone; Peptides; Reaction Time; Time Factors

1975
Heroin addiction. Sequential treatment employing pharmacologic supports.
    Archives of general psychiatry, 1976, Volume: 33, Issue:3

    Topics: Heroin Dependence; Humans; Methadone; Morphine; Naltrexone; Prognosis; Recurrence

1976
An evaluation of the hot plate technique to study narcotic antagonists.
    Research communications in chemical pathology and pharmacology, 1976, Volume: 13, Issue:4

    Topics: Animals; Male; Methods; Mice; Models, Biological; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Reaction Time; Time Factors

1976
Involvement of opioid mechanisms in peripheral motor control of detrusor muscle.
    Pharmacology & toxicology, 1992, Volume: 71, Issue:3 Pt 1

    Topics: Animals; Electric Stimulation; Enkephalins; Ganglionic Blockers; Hexamethonium; Hexamethonium Compounds; Humans; Indoles; Male; Morphinans; Morphine; Muscle Contraction; Muscles; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Substance P; Sympatholytics

1992
Perinatal morphine exposure alters peptidergic development in the striatum.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 1992, Volume: 10, Issue:6

    Topics: Animals; Blotting, Northern; Body Weight; Corpus Striatum; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Growth; Immunohistochemistry; In Situ Hybridization; Morphine; Naloxone; Naltrexone; Protein Precursors; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Substance P

1992
Morphine induces an increase in extracellular serotonin in the rat diencephalon.
    Brain research, 1992, Dec-25, Volume: 599, Issue:2

    Topics: Animals; Behavior, Animal; Catalepsy; Chromatography, High Pressure Liquid; Dialysis; Diencephalon; Electrochemistry; Hydroxyindoleacetic Acid; Male; Morphine; Naltrexone; Rats; Rats, Sprague-Dawley; Reaction Time; Serotonin

1992
Agonist and antagonist activity of kappa opioids in the squirrel monkey: I. Antinociception and urine output.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 260, Issue:1

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Behavior, Animal; Benzodiazepines; Benzomorphans; Drug Interactions; Ethylketocyclazocine; Male; Methadone; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Nociceptors; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Saimiri; Urination

1992
Agonist and antagonist activity of kappa opioids in the squirrel monkey: II. Effect of chronic morphine treatment.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 260, Issue:1

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzodiazepines; Benzomorphans; Drug Interactions; Drug Tolerance; Ethylketocyclazocine; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Nociceptors; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Saimiri; Shock; Time Factors

1992
Nonconventional opioid binding sites mediate growth inhibitory effects of methadone on human lung cancer cells.
    Proceedings of the National Academy of Sciences of the United States of America, 1992, Feb-15, Volume: 89, Issue:4

    Topics: Binding Sites; Calcium; Cell Death; Cell Division; Cell Membrane; Cyclic AMP; Cycloheximide; Dactinomycin; Growth Inhibitors; Humans; Methadone; Morphine; Naltrexone; Nicotine; Pertussis Toxin; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Stereoisomerism; Tumor Cells, Cultured; Virulence Factors, Bordetella

1992
Kappa opioid mediation of fetal responses to milk.
    Behavioral neuroscience, 1992, Volume: 106, Issue:2

    Topics: Aging; Animals; Arousal; Chemoreceptor Cells; Dose-Response Relationship, Drug; Female; Fetal Movement; Gestational Age; Morphine; Motor Activity; Naloxone; Naltrexone; Pregnancy; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Sucking Behavior; Taste; Touch

1992
Activation of the zinc finger encoding gene krox-20 in adult rat brain: comparison with zif268.
    Brain research. Molecular brain research, 1992, Volume: 13, Issue:3

    Topics: Animals; Apomorphine; Benzazepines; Brain; DNA-Binding Proteins; Early Growth Response Protein 1; Early Growth Response Protein 2; Electroshock; Haloperidol; Immediate-Early Proteins; Male; Morphine; Naltrexone; Nucleic Acid Hybridization; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Reserpine; Seizures; Substance Withdrawal Syndrome; Transcription Factors; Transcription, Genetic; Zinc Fingers

1992
Maintenance of acute morphine tolerance in mice by selective blockage of kappa opioid receptors with norbinaltorphimine.
    European journal of pharmacology, 1992, Jan-14, Volume: 210, Issue:2

    Topics: Animals; Drug Tolerance; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Receptors, Opioid, kappa; Spinal Cord

1992
Effect of adrenal and sex hormones on opioid analgesia and opioid receptor regulation.
    Pharmacology, biochemistry, and behavior, 1992, Volume: 42, Issue:4

    Topics: Adrenal Cortex Hormones; Adrenalectomy; Analgesics; Animals; Brain; Female; Gonadal Steroid Hormones; Male; Methadone; Mice; Morphine; Naltrexone; Narcotics; Orchiectomy; Ovariectomy; Reaction Time; Receptors, Opioid; Sex Characteristics; Up-Regulation

1992
Pentobarbital attenuates antinociception induced by i.c.v. morphine but not beta-endorphin in the mouse.
    European journal of pharmacology, 1992, Apr-22, Volume: 214, Issue:2-3

    Topics: Animals; beta-Endorphin; Drug Interactions; Enkephalin, Leucine; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Narcotic Antagonists; Nociceptors; Pentobarbital; Receptors, Opioid

1992
Spinal antinociception by Tyr-D-Ser(otbu)-Gly-Phe-Leu-Thr, a selective delta-opioid receptor agonist.
    European journal of pharmacology, 1992, May-27, Volume: 216, Issue:1

    Topics: Amino Acid Sequence; Analgesics; Animals; Dose-Response Relationship, Drug; Indoles; Injections, Spinal; Male; Molecular Sequence Data; Morphinans; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta

1992
Clocinnamox: a novel, systemically-active, irreversible opioid antagonist.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 262, Issue:3

    Topics: Analgesia; Animals; Cinnamates; Dose-Response Relationship, Drug; Fentanyl; Male; Mice; Morphine; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Receptors, Opioid

1992
Isobolographic and dose-response analyses of the interaction between intrathecal mu and delta agonists: effects of naltrindole and its benzofuran analog (NTB).
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 263, Issue:1

    Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Indoles; Injections, Spinal; Male; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu

1992
Chronic d-amphetamine inhibits opioid receptor antagonist-induced supersensitivity.
    European journal of pharmacology, 1992, Oct-20, Volume: 221, Issue:2-3

    Topics: Animals; Dextroamphetamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Mice; Morphine; Naltrexone; Receptors, Opioid; Up-Regulation

1992
Diprenorphine as a stimulus in drug discrimination learning.
    Pharmacology, biochemistry, and behavior, 1992, Volume: 43, Issue:3

    Topics: Animals; Chlorides; Conditioning, Psychological; Diprenorphine; Discrimination Learning; Dose-Response Relationship, Drug; Female; Generalization, Psychological; Lithium; Lithium Chloride; Morphine; Nalorphine; Naloxone; Naltrexone; Pentobarbital; Rats

1992
Opioid receptor antagonist affinity ligands: 6 beta-bromoacetamido-6-desoxynaltrexone and 6 beta-thioglycolamido-6-desoxynaltrexone.
    Neurochemical research, 1992, Volume: 17, Issue:12

    Topics: Affinity Labels; Analgesia; Animals; Brain; Cattle; Cell Membrane; Hydrogen-Ion Concentration; Kinetics; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Nicotine; Quinuclidinyl Benzilate; Receptors, Opioid

1992
Morphine- and naltrexone-induced modification of palatability: analysis by the taste reactivity test.
    Behavioral neuroscience, 1992, Volume: 106, Issue:6

    Topics: Animals; Arousal; Avoidance Learning; Brain; Dose-Response Relationship, Drug; Male; Morphine; Naltrexone; Quinine; Rats; Receptors, Opioid; Sucrose; Taste; Taste Threshold

1992
Opioid receptors mediating antinociception from beta-endorphin and morphine in the periaqueductal gray.
    Neuropharmacology, 1992, Volume: 31, Issue:11

    Topics: Amino Acid Sequence; Analgesics; Animals; beta-Endorphin; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Injections, Intraventricular; Male; Molecular Sequence Data; Morphine; Naltrexone; Narcotic Antagonists; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid

1992
Discriminative stimulus effects of cyclorphan: selective antagonism with naltrexone.
    Psychopharmacology, 1992, Volume: 106, Issue:2

    Topics: Animals; Columbidae; Dextrorphan; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Generalization, Psychological; Levorphanol; Morphinans; Morphine; Naltrexone; Receptors, Opioid; Receptors, Opioid, mu; Stereoisomerism

1992
Naloxone and norbinaltorphimine administered intracerebroventricularly antagonize spinal morphine-induced antinociception in mice through the antianalgesic action of spinal dynorphin A (1-17).
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 261, Issue:1

    Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Dynorphins; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Naltrexone

1992
Partial characterization of a neurotransmitter pathway regulating the in vivo release of prolactin.
    Neuroendocrinology, 1992, Volume: 55, Issue:5

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Bromocriptine; Haloperidol; Male; Mecamylamine; Methysergide; Morphine; Naltrexone; Narcotic Antagonists; Neurotransmitter Agents; Nicotine; Nicotinic Antagonists; Pituitary Gland; Prolactin; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Nicotinic; Receptors, Opioid; Receptors, Serotonin; Serotonin Antagonists; Tetrahydronaphthalenes

1992
Modulation of acute morphine tolerance by corticotropin-releasing factor and dynorphin A in the mouse spinal cord.
    Life sciences, 1992, Volume: 51, Issue:2

    Topics: Animals; Corticotropin-Releasing Hormone; Drug Tolerance; Dynorphins; Injections, Spinal; Male; Mice; Morphine; Naltrexone; Peptide Fragments; Spinal Cord

1992
Tyr-MIF-1 and hemorphin can act as opiate agonists as well as antagonists in the guinea pig ileum.
    Life sciences, 1992, Volume: 51, Issue:11

    Topics: Amino Acid Sequence; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Hemoglobins; Ileum; In Vitro Techniques; Male; Molecular Sequence Data; Morphine; MSH Release-Inhibiting Hormone; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists; Peptide Fragments; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu

1992
Effects of the opiates on the paraventricular nucleus in genetically polydipsic mice.
    Brain research, 1992, Dec-11, Volume: 598, Issue:1-2

    Topics: Animals; Dynorphins; Female; In Vitro Techniques; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Microinjections; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Neurons; Paraventricular Hypothalamic Nucleus; Quaternary Ammonium Compounds; Synapses; Thirst

1992
Discriminative stimulus properties of cocaine, alone and in combination with buprenorphine, morphine and naltrexone.
    Drug and alcohol dependence, 1992, Volume: 30, Issue:3

    Topics: Animals; Buprenorphine; Cocaine; Dextroamphetamine; Discrimination, Psychological; Dose-Response Relationship, Drug; Drug Combinations; Male; Morphine; Naltrexone; Rats; Sodium Chloride

1992
Reinstatement of heroin self-administration habits: morphine prompts and naltrexone discourages renewed responding after extinction.
    Psychopharmacology, 1992, Volume: 108, Issue:1-2

    Topics: Animals; Conditioning, Operant; Extinction, Psychological; Heroin Dependence; Injections, Intravenous; Morphine; Nalorphine; Naltrexone; Rats; Rats, Sprague-Dawley; Self Administration

1992
Repeated systemic administration of the mixed inhibitor of enkephalin-degrading enzymes, RB101, does not induce either antinociceptive tolerance or cross-tolerance with morphine.
    European journal of pharmacology, 1992, Nov-13, Volume: 223, Issue:1

    Topics: Analgesics; Animals; Disulfides; Dose-Response Relationship, Drug; Drug Tolerance; Indoles; Male; Mice; Morphinans; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Phenylalanine; Prodrugs; Reaction Time

1992
Naltrindole retards tolerance development to morphine-induced effects on EEG and EEG power spectra.
    European journal of pharmacology, 1992, Mar-17, Volume: 213, Issue:1

    Topics: Animals; Brain; Drug Tolerance; Electroencephalography; Female; Indoles; Injections, Intraventricular; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains

1992
Effects of nor-binaltorphimine on the development of analgesic tolerance to and physical dependence on morphine.
    European journal of pharmacology, 1992, Mar-17, Volume: 213, Issue:1

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics; Analysis of Variance; Animals; Behavior, Animal; Body Weight; Drug Tolerance; Male; Mice; Morphine; Morphine Dependence; Naltrexone; Pyrrolidines; Rats

1992
Differential effects of morphine and naltrexone on the antibody response in various mouse strains.
    Immunopharmacology and immunotoxicology, 1992, Volume: 14, Issue:3

    Topics: Animals; Antibody Formation; Drug Interactions; Female; Immune Tolerance; Male; Mice; Mice, Inbred Strains; Morphine; Naltrexone; Organ Size; Species Specificity; Spleen

1992
The effect of lipase on the release of naltrexone from triglyceride-coated cellulose acetate phthalate microspheres.
    Journal of biomedical materials research, 1992, Volume: 26, Issue:6

    Topics: Biocompatible Materials; Cellulose; Drug Delivery Systems; Enzyme Activation; Lipase; Materials Testing; Microscopy, Electron, Scanning; Microspheres; Morphine; Naltrexone; Triglycerides

1992
Apparent pA2 value of naltrexone is not changed in rats following continuous exposure to morphine or naloxone.
    Life sciences, 1992, Volume: 50, Issue:19

    Topics: Analysis of Variance; Animals; Body Weight; Dose-Response Relationship, Drug; Drug Interactions; Fentanyl; Male; Morphine; Naloxone; Naltrexone; Pain Measurement; Rats; Rats, Inbred Strains

1992
Opioid modulation of alcohol intake in monkeys by low doses of naltrexone and morphine.
    Annals of the New York Academy of Sciences, 1992, Jun-28, Volume: 654

    Topics: Alcohol Drinking; Animals; Dose-Response Relationship, Drug; Macaca mulatta; Male; Morphine; Naltrexone

1992
Pentazocine-induced biphasic analgesia in mice.
    Life sciences, 1991, Volume: 48, Issue:19

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics; Animals; Drug Administration Schedule; Drug Interactions; Drug Tolerance; Indoles; Injections, Intraventricular; Male; Mice; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Pentazocine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Time Factors

1991
The partial opioid agonist, buprenorphine, protects against lethal effects of cocaine.
    Drug and alcohol dependence, 1991, Volume: 27, Issue:2

    Topics: Animals; Brain; Buprenorphine; Cocaine; Dose-Response Relationship, Drug; Methadone; Mice; Mice, Inbred Strains; Morphine; Naltrexone; Receptors, Opioid; Receptors, Opioid, mu; Seizures

1991
Selective blockage of delta opioid receptors prevents the development of morphine tolerance and dependence in mice.
    The Journal of pharmacology and experimental therapeutics, 1991, Jul-01, Volume: 258, Issue:1

    Topics: Animals; Drug Implants; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Indoles; Isothiocyanates; Male; Mice; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Nociceptors; Receptors, Opioid; Receptors, Opioid, delta; Substance-Related Disorders; Thiocyanates

1991
Ontogeny of mu- and kappa-opiate receptor control of the hypothalamo-pituitary-adrenal axis in rats.
    Endocrinology, 1991, Volume: 129, Issue:2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenal Glands; Adrenocorticotropic Hormone; Animals; Corticosterone; Dexamethasone; Female; Hypothalamus; Kinetics; Morphine; Naltrexone; Pituitary Gland; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu

1991
Mirfentanil: pharmacological profile of a novel fentanyl derivative with opioid and nonopioid effects.
    The Journal of pharmacology and experimental therapeutics, 1991, Volume: 258, Issue:2

    Topics: Alfentanil; Analgesics; Animals; Columbidae; Discrimination Learning; Female; Fentanyl; In Vitro Techniques; Macaca mulatta; Male; Morphine; Naltrexone; Receptors, Opioid; Receptors, Opioid, mu; Respiration; Self Administration; Structure-Activity Relationship

1991
Characteristics of dose-dependent antagonism by beta-funaltrexamine of the antinociceptive effects of intrathecal mu agonists.
    The Journal of pharmacology and experimental therapeutics, 1991, Volume: 258, Issue:2

    Topics: Analgesics; Animals; Binding, Competitive; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fentanyl; Injections, Spinal; Male; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Spinal Cord; Sufentanil

1991
Dissociation of opioid receptor upregulation and functional supersensitivity.
    Pharmacology, biochemistry, and behavior, 1991, Volume: 38, Issue:4

    Topics: Analgesia; Animals; Binding Sites; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Kinetics; Male; Mice; Morphine; Naltrexone; Pertussis Toxin; Receptors, Opioid; Up-Regulation; Virulence Factors, Bordetella

1991
Opioids regulate the release of human chorionic gonadotropin hormone from trophoblast tissue.
    Life sciences, 1991, Volume: 49, Issue:11

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Benzeneacetamides; Chorionic Gonadotropin; Endorphins; Female; Humans; Morphine; Naltrexone; Placenta; Pregnancy; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Trophoblasts

1991
Footshock- and psychological-stress prevent the development of tolerance to spinal but not supraspinal morphine.
    Japanese journal of pharmacology, 1991, Volume: 56, Issue:2

    Topics: Animals; Drug Administration Routes; Drug Tolerance; Electroshock; Injections, Intraventricular; Injections, Spinal; Injections, Subcutaneous; Male; Mice; Mice, Inbred Strains; Morphine; Naltrexone; Receptors, Opioid; Stress, Psychological

1991
Isolation-induced vocalization in Wistar rat pups is not increased by naltrexone.
    Physiology & behavior, 1991, Volume: 49, Issue:6

    Topics: Animals; Arousal; Brain; Dose-Response Relationship, Drug; Endorphins; Maternal Deprivation; Morphine; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Social Isolation; Ultrasonics; Vocalization, Animal

1991
Evaluation of receptor mechanism mediating fentanyl analgesia and toxicity.
    European journal of pharmacology, 1991, May-17, Volume: 197, Issue:2-3

    Topics: Analgesics; Animals; Brain; Drug Tolerance; Fentanyl; Lethal Dose 50; Male; Mice; Morphine; Naloxone; Naltrexone; Receptors, Opioid

1991
Delta receptor involvement in morphine suppression of noxiously evoked activity of spinal WDR neurons in cats.
    Brain research, 1991, Jul-19, Volume: 554, Issue:1-2

    Topics: Analgesia; Animals; Cats; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Evoked Potentials; Female; Hot Temperature; Injections, Spinal; Male; Morphine; Naltrexone; Narcotic Antagonists; Neurons; Pain; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord

1991
Selective antagonism by naltrindole of the antinociceptive effects of the delta opioid agonist cyclic[D-penicillamine2-D-penicillamine5]enkephalin in the rat.
    The Journal of pharmacology and experimental therapeutics, 1991, Volume: 259, Issue:2

    Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Indoles; Injections, Spinal; Injections, Subcutaneous; Male; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Nociceptors; Pain Measurement; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord

1991
In vitro effect of high doses of morphine on Con A induced lymphokine production.
    Advances in experimental medicine and biology, 1991, Volume: 288

    Topics: Animals; beta-Endorphin; Cell Survival; Cells, Cultured; Clone Cells; Colforsin; Concanavalin A; Cyclic AMP; Depression, Chemical; Dinoprostone; Dose-Response Relationship, Drug; Enkephalins; Female; Lymphocyte Activation; Lymphokines; Mice; Mice, Inbred C57BL; Morphine; Naloxone; Naltrexone; Protein Biosynthesis; Receptors, Opioid; Spleen; T-Lymphocytes, Helper-Inducer

1991
Evaluation of the sites of opioid influence on anterior pituitary hormone secretion using a quaternary opiate antagonist.
    Neuroendocrinology, 1991, Volume: 54, Issue:4

    Topics: Analgesia; Animals; Brain Mapping; Male; Morphine; Naltrexone; Narcotic Antagonists; Neurons; Pain Measurement; Pituitary Hormones, Anterior; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu

1991
Role of spinal kappa opioid receptors in the blockade of the development of antinociceptive tolerance to morphine.
    European journal of pharmacology, 1991, Aug-06, Volume: 200, Issue:2-3

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Drug Tolerance; Injections, Intraventricular; Injections, Spinal; Injections, Subcutaneous; Male; Mice; Morphine; Naltrexone; Nociceptors; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Spinal Cord

1991
Modulation of mu-mediated antitussive activity in rats by a delta agonist.
    European journal of pharmacology, 1991, Oct-02, Volume: 203, Issue:1

    Topics: Aerosols; Animals; Antitussive Agents; Capsaicin; Cisterna Magna; Cough; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Indoles; Injections; Male; Morphinans; Morphine; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu

1991
Effects of intracerebroventricular beta-funaltrexamine on mu and delta opioid receptors in the rat: dichotomy between binding and antinociception.
    European journal of pharmacology, 1991, Oct-15, Volume: 203, Issue:2

    Topics: Animals; Brain; Cerebral Cortex; Corpus Striatum; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intravenous; Kinetics; Male; Morphine; Naltrexone; Narcotic Antagonists; Nociceptors; Periaqueductal Gray; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Thalamus; Time Factors; Tritium

1991
Spinal kappa receptor-mediated analgesia of E-2078, a systemically active dynorphin analog, in mice.
    The Journal of pharmacology and experimental therapeutics, 1991, Volume: 256, Issue:1

    Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Dynorphins; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Peptide Fragments; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord

1991
Separate neural mechanisms mediate sufentanil-induced pupillary responses in the cat.
    The Journal of pharmacology and experimental therapeutics, 1991, Volume: 256, Issue:3

    Topics: Analgesics, Opioid; Animals; Cats; Clonidine; Drug Interactions; Fentanyl; Male; Morphine; Mydriasis; Naltrexone; Pupil; Receptors, Opioid; Receptors, Opioid, mu; Sufentanil

1991
Involvement of spinal kappa opioid receptors in the antagonistic effect of dynorphins on morphine antinociception.
    Life sciences, 1991, Volume: 48, Issue:15

    Topics: Animals; Dynorphins; Indoles; Male; Mice; Morphinans; Morphine; Naltrexone; Pain; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Spine; Stereoisomerism

1991
Naltrexone-sensitizing effects of centrally administered morphine and opioid peptides.
    European journal of pharmacology, 1991, Jan-25, Volume: 193, Issue:1

    Topics: Animals; Conditioning, Operant; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Morphine; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta

1991
Serotonin contributes to the spinal antinociceptive effects of morphine.
    Pharmacology, biochemistry, and behavior, 1991, Volume: 39, Issue:3

    Topics: Adrenergic alpha-Antagonists; Adrenergic Antagonists; Analgesics; Animals; Biogenic Monoamines; Dose-Response Relationship, Drug; Injections, Spinal; Male; Morphine; Naltrexone; Nerve Endings; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Opioid; Serotonin; Serotonin Antagonists; Spinal Cord

1991
EEG evidence that morphine and an enkephalin analog cross the blood-brain barrier.
    Pharmacology, biochemistry, and behavior, 1991, Volume: 40, Issue:4

    Topics: Amino Acid Sequence; Animals; Blood-Brain Barrier; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Electroencephalography; Male; Molecular Sequence Data; Morphine; MSH Release-Inhibiting Hormone; Naltrexone; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains

1991
Chronic morphine administration augments benzodiazepine binding and GABAA receptor function.
    Psychopharmacology, 1990, Volume: 101, Issue:4

    Topics: Animals; Brain Chemistry; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chlorides; Chlorine; Flunitrazepam; In Vitro Techniques; Ion Channels; Male; Mice; Morphine; Muscimol; Naltrexone; Radioisotopes; Receptors, GABA-A; Sulfur Radioisotopes

1990
Induction of the c-fos proto-oncogene during opiate withdrawal in the locus coeruleus and other regions of rat brain.
    Brain research, 1990, Aug-20, Volume: 525, Issue:2

    Topics: Animals; Blotting, Northern; Brain; DNA-Binding Proteins; Locus Coeruleus; Male; Morphine; Naltrexone; Organ Specificity; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Proto-Oncogenes; Rats; Rats, Inbred Strains; RNA; RNA, Messenger; Substance Withdrawal Syndrome; Transcription Factors

1990
Chronic opioids impair acquisition of both radial maze and Y-maze choice escape.
    Psychopharmacology, 1991, Volume: 105, Issue:1

    Topics: Animals; Avoidance Learning; Behavior, Animal; Cognition; Drug Tolerance; Electroshock; Learning; Morphine; Naltrexone; Narcotics; Rats; Reaction Time; Sensory Thresholds; Vocalization, Animal

1991
Naltrexone does not reverse the inhibitory effect of chronic restraint on gonadotropin secretion in the intact male rat.
    Neuroendocrinology, 1991, Volume: 54, Issue:5

    Topics: Animals; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Hypothalamus; Luteinizing Hormone; Male; Morphine; Naltrexone; Orchiectomy; Rats; Rats, Inbred Strains; Restraint, Physical; Stress, Physiological

1991
Morphine-induced thymic hypoplasia is glucocorticoid-dependent.
    Journal of immunology (Baltimore, Md. : 1950), 1991, Jan-01, Volume: 146, Issue:1

    Topics: Adrenalectomy; Animals; Antigens, Differentiation, T-Lymphocyte; CD3 Complex; CD4 Antigens; CD8 Antigens; Dexamethasone; Glucocorticoids; Mice; Mice, Inbred C57BL; Morphine; Naltrexone; Receptors, Antigen, T-Cell; Receptors, Interleukin-2; T-Lymphocyte Subsets; Thymus Gland

1991
NMDA receptor antagonists suppress behaviors but not norepinephrine turnover or locus coeruleus unit activity induced by opiate withdrawal.
    European journal of pharmacology, 1991, May-02, Volume: 197, Issue:1

    Topics: Animals; Behavior, Animal; Dizocilpine Maleate; Electrophysiology; Isoquinolines; Locus Coeruleus; Male; Morphine; Naltrexone; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome

1991
Pharmacodynamic and pharmacokinetic actions of ketocyclazocine enantiomers in the dog: absence of sigma- or phencyclidine-like activity.
    The Journal of pharmacology and experimental therapeutics, 1991, Volume: 256, Issue:1

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Behavior, Animal; Dogs; Dose-Response Relationship, Drug; Drug Administration Schedule; Ethylketocyclazocine; Female; Morphine; Naltrexone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, sigma; Stereoisomerism; Time Factors

1991
The role of opioid receptor density in morphine tolerance.
    The Journal of pharmacology and experimental therapeutics, 1991, Volume: 256, Issue:2

    Topics: Animals; Drug Tolerance; Male; Mice; Morphine; Naltrexone; Receptors, Opioid; Species Specificity; Up-Regulation

1991
Antagonism of morphine antinociception by intrathecally administered corticotropin-releasing factor in mice.
    The Journal of pharmacology and experimental therapeutics, 1991, Volume: 256, Issue:3

    Topics: Analgesia; Animals; Corticotropin-Releasing Hormone; Dose-Response Relationship, Drug; Injections, Spinal; Male; Mice; Morphine; Naltrexone; Receptors, Opioid; Receptors, Opioid, kappa

1991
Effects of selective opiate antagonists on morphine-induced hyperalgesia in domestic fowl.
    Pharmacology, biochemistry, and behavior, 1991, Volume: 38, Issue:1

    Topics: Analgesia; Animals; Chickens; Dose-Response Relationship, Drug; Hot Temperature; Indoles; Injections, Intraventricular; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Respiration

1991
Comparison of naloxonazine and beta-funaltrexamine antagonism of mu 1 and mu 2 opioid actions.
    Life sciences, 1991, Volume: 48, Issue:21

    Topics: Animals; Drug Administration Schedule; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Subcutaneous; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, mu

1991
Endothelin-1-induced nociception.
    Life sciences, 1991, Volume: 49, Issue:11

    Topics: Animals; Endothelins; Male; Mice; Morphine; Naloxone; Naltrexone; Pain; Pain Measurement

1991
Effect of morphine administration on rat liver metallothionein and zinc metabolism.
    The Journal of pharmacology and experimental therapeutics, 1991, Volume: 259, Issue:1

    Topics: Animals; Immobilization; Injections, Subcutaneous; Liver; Male; Metallothionein; Mifepristone; Morphine; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Zinc

1991
Opioid-dependent behaviors in infant rats: effects of prenatal exposure to ethanol.
    Pharmacology, biochemistry, and behavior, 1991, Volume: 39, Issue:2

    Topics: Aging; Analgesia; Animals; Animals, Newborn; Behavior, Animal; Birth Weight; Diet; Ethanol; Female; Morphine; Naltrexone; Nociceptors; Opioid-Related Disorders; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred Strains; Social Isolation; Stress, Psychological; Vocalization, Animal

1991
Variable-ratio schedules of timeout from avoidance: effects of d-amphetamine and morphine.
    Journal of the experimental analysis of behavior, 1991, Volume: 56, Issue:2

    Topics: Animals; Arousal; Attention; Avoidance Learning; Dextroamphetamine; Male; Morphine; Naltrexone; Rats; Reinforcement Schedule

1991
Long-acting agonist and antagonist activities of naltrexamine bivalent ligands in mice.
    European journal of pharmacology, 1990, Sep-21, Volume: 186, Issue:2-3

    Topics: Analgesics; Animals; Injections, Intraventricular; Injections, Subcutaneous; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Receptors, Opioid; Receptors, Opioid, mu

1990
The opioid receptor selectivity for trimebutine in isolated tissues experiments and receptor binding studies.
    Journal of pharmacobio-dynamics, 1990, Volume: 13, Issue:7

    Topics: Animals; Drug Tolerance; Guinea Pigs; Ileum; Male; Mice; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Rabbits; Receptors, Opioid; Trimebutine; Vas Deferens

1990
Pharmacologic profile of NPC 168 (naltrexone phenyl oxime), a novel compound with activity at opioid receptors.
    Pharmacology, biochemistry, and behavior, 1990, Volume: 37, Issue:3

    Topics: Animals; Binding, Competitive; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Food Deprivation; Guinea Pigs; Injections, Intraventricular; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Reaction Time; Reinforcement Schedule

1990
beta-Funaltrexamine antagonizes the analgesic effects of mu and kappa agonists in the formalin test.
    Pharmacology, biochemistry, and behavior, 1990, Volume: 37, Issue:4

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Dose-Response Relationship, Drug; Ethylketocyclazocine; Formaldehyde; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Urination

1990
Antinociceptive effects of elevated plus-maze exposure: influence of opiate receptor manipulations.
    Psychopharmacology, 1990, Volume: 102, Issue:4

    Topics: Animals; Anxiety; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred DBA; Morphine; Naltrexone; Pain; Pain Measurement; Receptors, Opioid

1990
Clonidine, administered intracerebroventricularly in mice, produces an anti-analgesic effect which may be mediated spinally by dynorphin A (1-17).
    Neuropharmacology, 1990, Volume: 29, Issue:4

    Topics: Analgesics; Animals; Clonidine; Dynorphins; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Reaction Time

1990
Increased sensitivity to rate-altering and discriminative stimulus effects of morphine following continuous exposure to naltrexone.
    Psychopharmacology, 1991, Volume: 103, Issue:1

    Topics: Animals; Discrimination Learning; Discrimination, Psychological; Infusions, Intravenous; Male; Morphine; Naltrexone; Rats; Rats, Inbred Strains; Reaction Time; Reinforcement Schedule

1991
Delta opioid antagonist, naltrindole, selectively blocks analgesia induced by DPDPE but not DAGO or morphine.
    Pharmacology, biochemistry, and behavior, 1991, Volume: 38, Issue:1

    Topics: Analgesia; Analgesics; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Indoles; Injections, Intraventricular; Male; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Reaction Time; Restraint, Physical; Stress, Psychological

1991
Inhibition of calcium mobilization is an early event in opiate-induced immunosuppression.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 1991, Volume: 5, Issue:8

    Topics: Animals; Biological Transport, Active; Calcium; Concanavalin A; Dexamethasone; Flow Cytometry; Immune Tolerance; Mice; Mice, Inbred C57BL; Morphine; Naltrexone; Narcotics; Spleen; T-Lymphocytes

1991
Using antagonists to assess neurochemical coding of a drug's ability to establish a conditioned place preference.
    Pharmacology, biochemistry, and behavior, 1990, Volume: 37, Issue:3

    Topics: Analgesics; Animals; Brain Chemistry; Conditioning, Operant; Flumazenil; Habituation, Psychophysiologic; Male; Morphine; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Scopolamine

1990
Independence of benzodiazepine and opiate action in the suppression of isolation distress in rat pups.
    Behavioral neuroscience, 1990, Volume: 104, Issue:1

    Topics: Animals; Arousal; Chlordiazepoxide; Dose-Response Relationship, Drug; Flumazenil; Morphine; Motor Activity; Naltrexone; Rats; Rats, Inbred Strains; Social Isolation; Vocalization, Animal

1990
The role of pituitary beta-endorphin in mediating corticotropin-releasing factor-induced antinociception.
    The American journal of physiology, 1990, Volume: 258, Issue:2 Pt 1

    Topics: Analgesics; Animals; beta-Endorphin; Corticotropin-Releasing Hormone; Dexamethasone; Male; Morphine; Naltrexone; Pain; Pituitary Gland; Radioimmunoassay; Rats; Rats, Inbred Strains; Reference Values; Time Factors

1990
Kappa opioid partial agonist activity of the enkephalin-like pentapeptide BW942C based on urination and in vitro studies in humans and animals.
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 252, Issue:1

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adult; Amino Acid Sequence; Animals; Diuresis; Dose-Response Relationship, Drug; Drug Tolerance; Enkephalin, Methionine; Enkephalins; Humans; In Vitro Techniques; Male; Molecular Sequence Data; Morphine; Naltrexone; Oligopeptides; Phenazocine; Pyrrolidines; Rabbits; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Urination; Vas Deferens

1990
Suppression of lymphocyte activity after acute morphine administration appears to be glucocorticoid independent.
    Progress in clinical and biological research, 1990, Volume: 325

    Topics: Animals; Corticosterone; Immunosuppressive Agents; Killer Cells, Natural; Lymphocyte Activation; Lymphocytes; Morphine; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Spleen

1990
High-dose oral naltrexone: aversive response in drug-naive rat.
    Biological psychiatry, 1990, Mar-01, Volume: 27, Issue:5

    Topics: Animals; Avoidance Learning; Brain; Conditioning, Classical; Dose-Response Relationship, Drug; Drinking; Male; Morphine; Naltrexone; Nociceptors; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Opioid; Taste

1990
Apparent affinity of opioid antagonists in morphine-treated rhesus monkeys discriminating between saline and naltrexone.
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 252, Issue:2

    Topics: Animals; Discrimination Learning; Dose-Response Relationship, Drug; Female; Indoles; Macaca mulatta; Morphinans; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, mu

1990
Mu antagonist and kappa agonist properties of beta-funaltrexamine (beta-FNA) in vivo: long-lasting spinal analgesia in mice.
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 252, Issue:3

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics; Animals; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu

1990
Morphine inhibition of lymphocyte activity is mediated by an opioid dependent mechanism.
    Neuropharmacology, 1990, Volume: 29, Issue:4

    Topics: Animals; Cell Division; Cell Survival; Corticosterone; Hypothalamo-Hypophyseal System; Immunity, Cellular; Killer Cells, Natural; Lymphocytes; Male; Morphine; Naltrexone; Pituitary-Adrenal System; Rats; Rats, Inbred Strains; Receptors, Opioid; Spleen

1990
The ontogeny of opioid receptors mediating opiate-induced feeding in rats.
    Neuropharmacology, 1990, Volume: 29, Issue:5

    Topics: Aging; Animals; Body Weight; Eating; Female; Male; Morphine; Naltrexone; Narcotics; Rats; Receptors, Opioid

1990
Role of opiates in striatal D-1 dopamine receptor supersensitivity induced by chronic L-dopa treatment.
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 253, Issue:3

    Topics: Adenylyl Cyclases; Animals; Apomorphine; Corpus Striatum; Drug Interactions; Hydroxydopamines; Levodopa; Male; Morphine; Naltrexone; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Opioid

1990
Delta but not mu-opioid receptors in the spinal cord are involved in antinociception induced by beta-endorphin given intracerebroventricularly in mice.
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 253, Issue:3

    Topics: Analgesia; Animals; beta-Endorphin; Enkephalin, Leucine; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord

1990
Opioid agonist affinity in the guinea-pig ileum and mouse vas deferens.
    European journal of pharmacology, 1990, Apr-10, Volume: 179, Issue:1-2

    Topics: Animals; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Guinea Pigs; Ileum; Male; Methadone; Mice; Morphine; Morphine Derivatives; Naltrexone; Receptors, Opioid; Vas Deferens

1990
Nicotine protects against mu-opioid receptor antagonism by beta-funaltrexamine: evidence for nicotine-induced release of endogenous opioids in brain.
    Neuroscience letters, 1990, May-18, Volume: 113, Issue:1

    Topics: Analgesia; Animals; Brain; Endorphins; Injections, Intraventricular; Male; Morphine; Naltrexone; Nicotine; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu

1990
"Paradoxical" analgesia and aggravated morphine dependence induced by opioid antagonists.
    Life sciences, 1990, Volume: 47, Issue:6

    Topics: Animals; Body Weight; Indoles; Male; Morphinans; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome; Substance-Related Disorders

1990
Further evidence for the implication of a kappa-opioid receptor mechanism in the production of psychological stress-induced analgesia.
    Japanese journal of pharmacology, 1990, Volume: 53, Issue:4

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics; Animals; Benzomorphans; Drug Tolerance; Electroshock; Indoles; Male; Mice; Mice, Inbred Strains; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Stress, Psychological; Swimming

1990
Antinociceptive effects of [D-Ala2]deltorphin II, a highly selective delta agonist in vivo.
    Life sciences, 1990, Volume: 47, Issue:11

    Topics: Analgesics; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Injections, Intraventricular; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Narcotic Antagonists; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta

1990
Perinatal opiate treatment delays growth of cortical dendrites.
    Neuroscience letters, 1990, Jul-31, Volume: 115, Issue:2-3

    Topics: Animals; Animals, Newborn; Dendrites; Female; Male; Morphine; Naltrexone; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred Strains; Receptors, Opioid; Somatosensory Cortex

1990
Morphine promotes the growth of HIV-1 in human peripheral blood mononuclear cell cocultures.
    AIDS (London, England), 1990, Volume: 4, Issue:9

    Topics: Cells, Cultured; Gene Products, gag; HIV Core Protein p24; HIV-1; Humans; Leukocytes, Mononuclear; Lymphocyte Activation; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Viral Core Proteins

1990
Hepatobiliary effects of morphine are mediated in the brain.
    Hepatology (Baltimore, Md.), 1990, Volume: 12, Issue:6

    Topics: Animals; Biliary Tract; Brain; Female; Injections, Intraperitoneal; Injections, Intravenous; Injections, Intraventricular; Injections, Subcutaneous; Liver; Male; Mice; Morphine; Naloxone; Naltrexone; Receptors, Opioid; Sulfobromophthalein

1990
Assessment of relative intrinsic activity of mu-opioid analgesics in vivo by using beta-funaltrexamine.
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 255, Issue:3

    Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Fentanyl; Levorphanol; Male; Methadone; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Time Factors

1990
In vivo and in vitro investigation of naltrindole, a delta-opioid antagonist.
    Proceedings of the Western Pharmacology Society, 1990, Volume: 33

    Topics: Animals; Dose-Response Relationship, Drug; Electric Stimulation; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Indoles; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphinans; Morphine; Muscle Contraction; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Reaction Time; Receptors, Opioid; Receptors, Opioid, delta; Vas Deferens

1990
Simultaneous development of opioid tolerance and opioid antagonist-induced receptor upregulation.
    Brain research, 1990, Oct-08, Volume: 529, Issue:1-2

    Topics: Analgesia; Animals; Brain; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Kinetics; Male; Mice; Morphine; Naloxone; Naltrexone; Pain; Receptors, Opioid; Reference Values; Up-Regulation

1990
Pharmacokinetics of morphine and its surrogates. XI: Effect of simultaneously administered naltrexone and morphine on the pharmacokinetics and pharmacodynamics of each in the dog.
    Biopharmaceutics & drug disposition, 1990, Volume: 11, Issue:5

    Topics: Animals; Bile; Dogs; Half-Life; Morphine; Morphine Derivatives; Naltrexone; Pupil

1990
Suppressive effects of morphine pellet implants on in vivo parameters of immune function.
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 255, Issue:2

    Topics: Animals; Drug Implants; Hypersensitivity, Delayed; Hypothalamo-Hypophyseal System; Immunosuppressive Agents; Lymphocyte Activation; Male; Mice; Mice, Inbred C3H; Morphine; Naltrexone; Pituitary-Adrenal System; Spleen

1990
Augmentation of morphine-induced changes in brain monoamine metabolism after chronic naltrexone treatment.
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 255, Issue:2

    Topics: Animals; Brain; Brain Chemistry; Dopamine; Male; Morphine; Naltrexone; Norepinephrine; Rats; Rats, Inbred Strains; Serotonin

1990
Context-specific morphine withdrawal in rats: duration and effects of clonidine.
    Behavioral neuroscience, 1990, Volume: 104, Issue:5

    Topics: Animals; Arousal; Association Learning; Clonidine; Male; Morphine; Morphine Dependence; Motor Activity; Naltrexone; Rats; Social Environment; Substance Withdrawal Syndrome; Weight Loss

1990
[D-Pen2, D-Pen5]enkephalin, the standard delta opioid agonist, induces morphine-like behaviors in mice.
    Psychopharmacology, 1990, Volume: 102, Issue:3

    Topics: Analgesics; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Motor Activity; Muscle Tonus; Naloxone; Naltrexone; Narcotic Antagonists; Stereotyped Behavior

1990
Antitussive effects of two specific kappa-opioid agonists, U-50,488H and U-62,066E, in rats.
    European journal of pharmacology, 1990, Oct-09, Volume: 187, Issue:2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Antitussive Agents; Cisterna Magna; Cough; Injections; Ketanserin; Male; Methysergide; Morphine; Naloxone; Naltrexone; Pyrrolidines; Rats; Rats, Inbred Strains; Reflex

1990
Opiates suppress carrageenan-induced edema and hyperthermia at doses that inhibit hyperalgesia.
    Pain, 1990, Volume: 43, Issue:1

    Topics: Analgesics; Animals; Body Temperature; Carrageenan; Dextrorphan; Dose-Response Relationship, Drug; Edema; Levorphanol; Male; Morphine; Naltrexone; Narcotics; Pain; Rats; Rats, Inbred Strains; Stereoisomerism

1990
Antagonism of the acute pharmacological actions of morphine by panax ginseng extract.
    General pharmacology, 1990, Volume: 21, Issue:6

    Topics: Analgesia; Animals; Body Temperature; Colon; Drugs, Chinese Herbal; Fever; Male; Morphine; Naltrexone; Pain Measurement; Panax; Plants, Medicinal; Rats; Rats, Inbred Strains

1990
Pharmacological regulation of striatal prodynorphin peptides.
    Progress in clinical and biological research, 1990, Volume: 328

    Topics: Amphetamine; Animals; Corpus Striatum; Drug Interactions; Enkephalins; Haloperidol; Male; Morphine; Naltrexone; Protein Precursors; Rats; Rats, Inbred Strains; Substantia Nigra

1990
Effects of the enkephalinase inhibitor SCH 34826 on the sleep-waking cycle and EEG activity in the rat.
    Neuropharmacology, 1990, Volume: 29, Issue:3

    Topics: Animals; Dioxolanes; Dioxoles; Dipeptides; Dose-Response Relationship, Drug; Electroencephalography; Male; Morphine; Naltrexone; Neprilysin; Rats; Rats, Inbred Strains; Sleep; Sleep, REM; Thiorphan; Wakefulness

1990
Peripheral and central opioid activity in the analgesic potency of morphine.
    Agents and actions, 1990, Volume: 30, Issue:1-2

    Topics: Analgesics; Animals; Histamine; Injections, Intraperitoneal; Injections, Intraventricular; Male; Methylhistidines; Morphine; Naltrexone; Rats; Rats, Inbred Strains; Reaction Time

1990
Enhanced sensitivity to behavioral effects of naltrexone in rats.
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 252, Issue:1

    Topics: Animals; Conditioning, Psychological; Cyclazocine; Dose-Response Relationship, Drug; Ethylketocyclazocine; Male; Morphine; Naloxone; Naltrexone; Rats; Salivation

1990
Action of naloxone on myenteric neurons removed from morphine-treated guinea pigs.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 247, Issue:3

    Topics: Acetylcholine; Action Potentials; Animals; Endorphins; Guinea Pigs; Ileum; In Vitro Techniques; Magnesium; Morphine; Muscle Contraction; Myenteric Plexus; Naloxone; Naltrexone; Substance P

1988
Suppression of natural killer cell activity by high-dose narcotic anesthesia in rats.
    Brain, behavior, and immunity, 1989, Volume: 3, Issue:2

    Topics: Anesthesia; Cytotoxicity Tests, Immunologic; Dose-Response Relationship, Drug; Fentanyl; Interferons; Killer Cells, Natural; Morphine; Naltrexone; Sufentanil; Time Factors

1989
Simultaneous extraction and chromatographic analysis of morphine, dilaudid, naltrexone and naloxone in biological fluids by high-performance liquid chromatography with electrochemical detection.
    Journal of chromatography, 1989, Jun-30, Volume: 491, Issue:1

    Topics: Animals; Chromatography, High Pressure Liquid; Electrochemistry; Hydromorphone; Male; Morphine; Naloxone; Naltrexone; Rats

1989
Phosphodiesterase inhibitors potentiate opiate-antagonist discrimination by morphine-dependent rats.
    Pharmacology, biochemistry, and behavior, 1989, Volume: 33, Issue:4

    Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Body Weight; Discrimination, Psychological; Dose-Response Relationship, Drug; Drug Synergism; Male; Morphine; Naltrexone; Narcotic Antagonists; Papaverine; Phosphodiesterase Inhibitors; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome; Substance-Related Disorders

1989
Effects of prior saline-morphine discrimination by pigeons on three-way discrimination including two morphine doses.
    Psychopharmacology, 1989, Volume: 98, Issue:2

    Topics: Animals; Columbidae; Dextroamphetamine; Discrimination, Psychological; Dose-Response Relationship, Drug; Morphine; Naltrexone

1989
Down-regulation of proopiomelanocortin synthesis and beta-endorphin utilization in hypothalamus of morphine-tolerant rats.
    Journal of molecular neuroscience : MN, 1989, Volume: 1, Issue:1

    Topics: Animals; beta-Endorphin; Corpus Striatum; Drug Tolerance; Enkephalin, Methionine; Enkephalins; Hypothalamus; Male; Morphine; Naltrexone; Pro-Opiomelanocortin; Protein Precursors; Rats; Rats, Inbred Strains; Reference Values; RNA, Messenger; Substance Withdrawal Syndrome

1989
Analgesia produced by normal doses of opioid antagonists alone and in combination with morphine.
    Pain, 1989, Volume: 36, Issue:1

    Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Female; Mice; Mice, Inbred BALB C; Morphine; Naloxone; Naltrexone; Pain Measurement; Receptors, Opioid

1989
Effects of kappa opioids on schedule-controlled behavior of squirrel monkeys.
    The Journal of pharmacology and experimental therapeutics, 1989, Volume: 248, Issue:3

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzomorphans; Conditioning, Psychological; Dose-Response Relationship, Drug; Electroshock; Male; Morphinans; Morphine; Naltrexone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Saimiri

1989
Conditioned opioid release in ten-day-old rats.
    Behavioral neuroscience, 1989, Volume: 103, Issue:2

    Topics: Animals; Arousal; Association Learning; Brain; Conditioning, Classical; Endorphins; Female; Learning; Male; Morphine; Naltrexone; Nociceptors; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Opioid; Smell; Synaptic Transmission

1989
Chronic administration of morphine and naltrexone up-regulate mu-opioid binding sites labeled by [3H][D-Ala2,MePhe4,Gly-ol5]enkephalin: further evidence for two mu-binding sites.
    European journal of pharmacology, 1989, Jan-24, Volume: 160, Issue:1

    Topics: Animals; Benzomorphans; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; In Vitro Techniques; Male; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu

1989
Novelty-induced place preference behavior in rats: effects of opiate and dopaminergic drugs.
    Pharmacology, biochemistry, and behavior, 1989, Volume: 32, Issue:3

    Topics: Amphetamines; Animals; Dose-Response Relationship, Drug; Exploratory Behavior; Haloperidol; Male; Morphine; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Opioid

1989
Involvement of opioid and dopaminergic systems in isolation-induced pinning and social grooming of young rats.
    Neuropharmacology, 1989, Volume: 28, Issue:4

    Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Endorphins; Grooming; Haloperidol; Male; Morphine; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Opioid; Social Behavior; Social Isolation

1989
Procedures that produce context-specific tolerance to morphine in rats also produce context-specific withdrawal.
    Behavioral neuroscience, 1989, Volume: 103, Issue:4

    Topics: Animals; Brain; Dose-Response Relationship, Drug; Drug Tolerance; Male; Morphine; Morphine Dependence; Naltrexone; Nociceptors; Rats; Rats, Inbred Strains; Receptors, Opioid; Social Environment; Substance Withdrawal Syndrome; Thermosensing

1989
Pharmacological characterization of supersensitivity to naltrexone in squirrel monkeys.
    The Journal of pharmacology and experimental therapeutics, 1989, Volume: 250, Issue:3

    Topics: Animals; Azocines; Behavior, Animal; Benzomorphans; Diprenorphine; Drug Administration Schedule; Morphine; Naloxone; Naltrexone; Receptors, Opioid; Saimiri

1989
Discriminative stimulus effects of naltrexone in morphine-treated rhesus monkeys.
    The Journal of pharmacology and experimental therapeutics, 1989, Volume: 250, Issue:3

    Topics: Animals; Discrimination Learning; Dose-Response Relationship, Drug; Female; Macaca mulatta; Morphine; Naltrexone; Receptors, Opioid; Substance Withdrawal Syndrome

1989
Effects of opioid receptor antagonists on morphine-induced stupor in rabbits.
    Activitas nervosa superior, 1989, Volume: 31, Issue:2

    Topics: Animals; Coma; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rabbits; Receptors, Opioid

1989
Effects of chronic morphine administration on the mu and delta opioid responses in the CA1 region of the rat hippocampus.
    The Journal of pharmacology and experimental therapeutics, 1989, Volume: 251, Issue:2

    Topics: Animals; Drug Tolerance; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hippocampus; In Vitro Techniques; Male; Morphine; Naltrexone; Phosphorylation; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu

1989
Identification of morphine- and cyclic AMP-regulated phosphoproteins (MARPPs) in the locus coeruleus and other regions of rat brain: regulation by acute and chronic morphine.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1989, Volume: 9, Issue:12

    Topics: Animals; Brain; Colforsin; Cyclic AMP; Locus Coeruleus; Male; Morphine; Naltrexone; Phosphoproteins; Phosphorylation; Protein Kinases; Proteins; Rats; Rats, Inbred Strains; Time Factors

1989
Kappa opioid receptors of human placental villi modulate acetylcholine release.
    Life sciences, 1989, Volume: 45, Issue:25

    Topics: Acetylcholine; Chorionic Villi; Diltiazem; Female; Humans; In Vitro Techniques; Kinetics; Morphine; Naloxone; Naltrexone; Pregnancy; Receptors, Opioid; Receptors, Opioid, kappa

1989
Chronic opioid antagonist treatment: assessment of receptor upregulation.
    European journal of pharmacology, 1989, Nov-07, Volume: 170, Issue:3

    Topics: Animals; Binding, Competitive; Brain Chemistry; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Kinetics; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Up-Regulation

1989
Site-directed affinity ligands as tools to study the phenomenology and mechanisms of morphine-induced upregulation of opioid receptors.
    NIDA research monograph, 1989, Volume: 95

    Topics: Animals; Brain; Morphine; Naltrexone; Rats; Receptors, Opioid; Receptors, Opioid, delta; Synaptic Membranes; Up-Regulation

1989
Evaluation of delta receptor mediation of supraspinal opioid analgesia by in vivo protection against the beta-funaltrexamine antagonist effect.
    European journal of pharmacology, 1989, Jan-02, Volume: 159, Issue:1

    Topics: Analgesics, Opioid; Animals; Brain Chemistry; Dihydromorphine; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; In Vitro Techniques; Injections, Intraventricular; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Pain Measurement; Receptors, Opioid; Receptors, Opioid, delta

1989
Effects of opioid agonists on urine production in neonatal rats.
    The Journal of pharmacy and pharmacology, 1989, Volume: 41, Issue:4

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Animals, Newborn; Benzodiazepines; Body Weight; Female; Male; Morphine; Naltrexone; Narcotics; Phentolamine; Pyrrolidines; Rats; Rats, Inbred Strains; Urodynamics

1989
The antinociceptive effects of 3,4-methylenedioxymethamphetamine (MDMA) in the rat.
    Pharmacology, biochemistry, and behavior, 1989, Volume: 34, Issue:3

    Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Analgesics; Animals; Dose-Response Relationship, Drug; Male; Methysergide; Morphine; N-Methyl-3,4-methylenedioxyamphetamine; Naltrexone; Pain; Rats; Rats, Inbred Strains; Receptors, Serotonin

1989
Naltrexone blocks nicotine-induced prolactin release.
    Neuropharmacology, 1989, Volume: 28, Issue:11

    Topics: Animals; Catheterization; Male; Mecamylamine; Morphine; Naltrexone; Nicotine; Prolactin; Rats; Rats, Inbred Strains

1989
Withdrawal-induced activation of locus coeruleus neurons in opiate-dependent rats: attenuation by lesions of the nucleus paragigantocellularis.
    Brain research, 1989, Dec-29, Volume: 505, Issue:2

    Topics: Action Potentials; Animals; Kynurenic Acid; Locus Coeruleus; Male; Medulla Oblongata; Morphine; Naltrexone; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome

1989
Naltrexone discrimination in morphine-treated monkeys.
    NIDA research monograph, 1989, Volume: 95

    Topics: Animals; Avoidance Learning; Discrimination Learning; Dose-Response Relationship, Drug; Injections, Subcutaneous; Macaca mulatta; Morphine; Naltrexone

1989
Intracerebroventricular N-ethylmaleimide differentially reduces supraspinal opioid analgesia in mice.
    European journal of pharmacology, 1989, Jul-18, Volume: 166, Issue:2

    Topics: Analgesics; Animals; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylmaleimide; Injections, Intraventricular; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Sulfhydryl Reagents

1989
Studies on the mechanism of hypoglycemia induced by intrathecal morphine: dissociation from behavioral effects, effects of tolerance and depletion of liver glycogen.
    The Journal of pharmacology and experimental therapeutics, 1989, Volume: 249, Issue:3

    Topics: Animals; Behavior, Animal; Drug Interactions; Drug Tolerance; Female; Hypoglycemia; Injections, Spinal; Liver; Liver Glycogen; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Pentobarbital; Rats; Rats, Inbred Strains; Species Specificity; Strychnine

1989
Locus ceruleus discharge characteristics of morphine-dependent rats: effects of naltrexone.
    Brain research, 1989, May-29, Volume: 488, Issue:1-2

    Topics: Action Potentials; Animals; Locus Coeruleus; Male; Morphine; Naltrexone; Rats; Rats, Inbred Strains; Substance-Related Disorders

1989
Delayed suppression of serum luteinizing hormone after naloxone treatment in neonatal female rats.
    Life sciences, 1989, Volume: 44, Issue:26

    Topics: Animals; Animals, Newborn; Female; Luteinizing Hormone; Morphine; Naloxone; Naltrexone; Pain; Rats; Rats, Inbred Strains; Secretory Rate; Time Factors

1989
The periaqueductal gray matter mediates opiate-induced immunosuppression.
    Science (New York, N.Y.), 1989, Jul-14, Volume: 245, Issue:4914

    Topics: Animals; Immune Tolerance; Killer Cells, Natural; Male; Mesencephalon; Microinjections; Morphine; Naltrexone; Rats; Rats, Inbred F344

1989
Effects of acute morphine administration on noradrenaline turnover and metabolism in various brain parts of control and handled rats.
    Pharmacology & toxicology, 1989, Volume: 64, Issue:2

    Topics: Animals; Brain Chemistry; Dose-Response Relationship, Drug; Male; Methoxyhydroxyphenylglycol; Morphine; Naltrexone; Norepinephrine; Rats; Rats, Inbred Strains; Stress, Physiological

1989
Perturbation of glutathione by a central action of morphine.
    Toxicology, 1989, Volume: 57, Issue:3

    Topics: Animals; Blood Gas Analysis; Body Temperature; Glutathione; Liver; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Oxidation-Reduction; Oxygen

1989
The tegmental pedunculopontine nucleus: a brain-stem output of the limbic system critical for the conditioned place preferences produced by morphine and amphetamine.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1989, Volume: 9, Issue:10

    Topics: Amphetamine; Animals; Brain Stem; Conditioning, Psychological; Dose-Response Relationship, Drug; Limbic System; Male; Morphine; Naltrexone; Narcotic Antagonists; Periaqueductal Gray; Pons; Psychotropic Drugs; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Retention, Psychology; Tegmentum Mesencephali

1989
Central vs. peripheral mediation of opioid effects on alcohol consumption in free-feeding rats.
    Pharmacology, biochemistry, and behavior, 1989, Volume: 33, Issue:2

    Topics: Alcohol Drinking; Animals; Dose-Response Relationship, Drug; Drinking Behavior; Drug Interactions; Loperamide; Male; Morphine; Naltrexone; Narcotic Antagonists; Piperidines; Polysorbates; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Time Factors

1989
Does the blockade of opioid receptors influence the development of ethanol dependence?
    Alcohol and alcoholism (Oxford, Oxfordshire), 1987, Volume: 22, Issue:2

    Topics: Alcoholism; Animals; Diprenorphine; Female; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Seizures; Substance Withdrawal Syndrome

1987
Multiple opiate receptors and pharmacological response to morphine in rats maintained on diets differing in protein concentration.
    General pharmacology, 1987, Volume: 18, Issue:5

    Topics: Analgesics; Animals; Body Temperature; Body Weight; Brain; Dietary Proteins; Drinking; Drug Interactions; Eating; Male; Morphine; Naltrexone; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Opioid

1987
Chronic opioid antagonist treatment facilitates nonopioid, stress-induced analgesia.
    Pharmacology, biochemistry, and behavior, 1987, Volume: 27, Issue:3

    Topics: Animals; Cold Temperature; Drug Implants; Male; Morphine; Naltrexone; Pain; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Opioid; Stress, Physiological; Swimming

1987
Effects of beta-funaltrexamine on radiolabeled opioid binding.
    European journal of pharmacology, 1987, Aug-11, Volume: 140, Issue:2

    Topics: Animals; Binding, Competitive; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; In Vitro Techniques; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu

1987
Evidence for the interaction of morphine with kappa and delta opioid receptors to induce analgesia in beta-funaltrexamine-treated mice.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 243, Issue:1

    Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa

1987
Opioid delta-receptor involvement in supraspinal and spinal antinociception in mice.
    Brain research, 1987, Sep-08, Volume: 420, Issue:1

    Topics: Animals; Brain; Dose-Response Relationship, Drug; Drug Combinations; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Hot Temperature; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Nociceptors; Pain; Receptors, Opioid; Receptors, Opioid, delta; Spinal Cord

1987
Cellular mechanisms of opioid tolerance: studies in single brain neurons.
    Molecular pharmacology, 1987, Volume: 32, Issue:5

    Topics: Animals; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; In Vitro Techniques; Locus Coeruleus; Male; Membrane Potentials; Morphine; Morphine Derivatives; Naltrexone; Neurons; Potassium; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu

1987
Peripheral receptors mediate the aversive conditioning effects of morphine in the rat.
    Pharmacology, biochemistry, and behavior, 1987, Volume: 28, Issue:2

    Topics: Amphetamine; Animals; Capsaicin; Chlorides; Conditioning, Classical; Injections, Intraperitoneal; Lithium; Lithium Chloride; Male; Morphine; Naltrexone; Peritoneal Cavity; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Receptors, Opioid; Taste

1987
Chronic naltrexone supersensitizes the reinforcing and locomotor-activating effects of morphine.
    Pharmacology, biochemistry, and behavior, 1987, Volume: 28, Issue:2

    Topics: Animals; Conditioning, Classical; Drug Synergism; Male; Morphine; Motor Activity; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Reinforcement, Psychology

1987
Chronic morphine upregulates a mu-opiate binding site labeled by [3H]cycloFOXY: a novel opiate antagonist suitable for positron emission tomography.
    European journal of pharmacology, 1987, Oct-06, Volume: 142, Issue:1

    Topics: Alkylating Agents; Animals; Binding, Competitive; Drug Tolerance; Enkephalin, Leucine; In Vitro Techniques; Male; Morphine; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Tomography, Emission-Computed

1987
Effects of stress and beta-funal trexamine pretreatment on morphine analgesia and opioid binding in rats.
    Life sciences, 1987, Dec-28, Volume: 41, Issue:26

    Topics: Analgesia; Animals; Brain; Male; Morphine; Naltrexone; Narcotics; Rats; Rats, Inbred Strains; Receptors, Opioid; Stress, Physiological

1987
Opioid analgesia in the mouse: evidence for multiple receptors using beta-FNA.
    NIDA research monograph, 1986, Volume: 75

    Topics: Analgesia; Animals; Enkephalins; Male; Mice; Mice, Inbred Strains; Morphine; Naltrexone; Narcotic Antagonists; Pain; Receptors, Opioid

1986
Potentiation of pentobarbital sleeping time by the acute and chronic administration of morphine.
    NIDA research monograph, 1987, Volume: 76

    Topics: Animals; Drug Synergism; Male; Morphine; Naltrexone; Pentobarbital; Rats; Rats, Inbred Strains; Receptors, Opioid; Sleep

1987
Roles of central and peripheral mu, delta and kappa opioid receptors in the mediation of gastric acid secretory effects in the rat.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 244, Issue:2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Brain; Cyclazocine; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; Gastric Acid; Male; Morphine; Naltrexone; Pyrrolidines; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu

1988
Binaltorphimine-related bivalent ligands and their kappa opioid receptor antagonist selectivity.
    Journal of medicinal chemistry, 1988, Volume: 31, Issue:4

    Topics: Animals; Chemical Phenomena; Chemistry; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Male; Mice; Models, Molecular; Morphine; Muscle, Smooth; Naltrexone; Receptors, Opioid; Receptors, Opioid, kappa; Structure-Activity Relationship

1988
Only one pharmacophore is required for the kappa opioid antagonist selectivity of norbinaltorphimine.
    Journal of medicinal chemistry, 1988, Volume: 31, Issue:7

    Topics: Animals; Chemical Phenomena; Chemistry; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Ileum; Male; Mice; Morphine; Naltrexone; Receptors, Opioid; Receptors, Opioid, kappa; Stereoisomerism; Structure-Activity Relationship; Vas Deferens

1988
Nor-binaltorphimine, a highly selective kappa-opioid antagonist in analgesic and receptor binding assays.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 246, Issue:1

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Guinea Pigs; Male; Mice; Morphine; Naltrexone; Oligopeptides; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa

1988
Upregulation of opioid receptor subtypes correlates with potency changes of morphine and DADLE.
    Life sciences, 1988, Volume: 43, Issue:16

    Topics: Animals; Brain; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Mice; Morphine; Naltrexone; Pain; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu

1988
Centrally mediated opioid induced depression of hepatic glutathione: effects of intracerebroventricular administration of mu, kappa, sigma and delta agonists.
    Toxicology, 1988, Volume: 51, Issue:2-3

    Topics: Animals; Brain; Circadian Rhythm; Dose-Response Relationship, Drug; Glutathione; Injections, Intraventricular; Liver; Male; Mice; Morphine; Naltrexone; Narcotics; Receptors, Opioid; Time Factors

1988
Central pharmacological activity of a quaternary ammonium compound in streptozotocin diabetic mice.
    Life sciences, 1988, Volume: 43, Issue:17

    Topics: Animals; Blood-Brain Barrier; Cell Membrane Permeability; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Female; Injections, Subcutaneous; Insulin; Mice; Morphine; Naltrexone; Narcotic Antagonists; Pharmaceutical Vehicles; Quaternary Ammonium Compounds; Streptozocin

1988
Chronic administration of morphine and naltrexone up-regulate[3H][D-Ala2,D-leu5]enkephalin binding sites by different mechanisms.
    Neuropharmacology, 1988, Volume: 27, Issue:9

    Topics: Animals; Drug Tolerance; Male; Morphine; Morphine Dependence; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Sodium Chloride

1988
Suppression by nor-binaltorphimine of kappa opioid-mediated diuresis in rats.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 247, Issue:3

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Diuresis; Dose-Response Relationship, Drug; Male; Morphine; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa

1988
Chronic treatment with naltrexone enhances morphine-stimulated dopamine neurotransmission: neurochemical and behavioral evidence.
    Neuropharmacology, 1988, Volume: 27, Issue:11

    Topics: Animals; Brain Chemistry; Dihydroxyphenylalanine; Dopamine; Male; Morphine; Motor Activity; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Synaptic Transmission

1988
Opposite effects of mu and kappa opiate agonists on dopamine release in the nucleus accumbens and in the dorsal caudate of freely moving rats.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 244, Issue:3

    Topics: Animals; Benzomorphans; Caudate Nucleus; Dopamine; Male; Methadone; Morphine; Motor Activity; Naloxone; Naltrexone; Nucleus Accumbens; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reward; Septal Nuclei

1988
Inhibition by opioid agonists and enhancement by antagonists of the release of catecholamines from the dog adrenal gland in response to splanchnic nerve stimulation: evidence for the functional role of opioid receptors.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 244, Issue:3

    Topics: Adrenal Glands; Animals; Catecholamines; Dogs; Electric Stimulation; Enkephalin, Leucine; Female; Male; Morphine; Naloxone; Naltrexone; Receptors, Opioid; Splanchnic Nerves

1988
Analeptic effect of opiate receptor agonists in rabbits.
    Neuroscience letters, 1985, Mar-22, Volume: 55, Issue:1

    Topics: Animals; Arousal; Brain; Central Nervous System Stimulants; Codeine; Cyclazocine; Dose-Response Relationship, Drug; Enkephalin, Methionine; Ethylketocyclazocine; Etorphine; Male; Meperidine; Methadone; Morphine; Naltrexone; Narcotics; Phenazocine; Rabbits; Receptors, Opioid; Reflex

1985
Non-dopaminergic mechanisms in the turning behavior evoked by intranigral opiates.
    Brain research, 1985, Aug-26, Volume: 341, Issue:2

    Topics: Animals; Dynorphins; Enkephalins; Hydroxydopamines; Male; Medial Forebrain Bundle; Morphine; Movement; Naltrexone; Neural Pathways; Oxidopamine; Rats; Rats, Inbred Strains; Substantia Nigra

1985
An analysis of naltrexone and naloxone's possible agonistic actions in the dog.
    Drug and alcohol dependence, 1985, Volume: 15, Issue:4

    Topics: Analgesics, Opioid; Animals; Cyclazocine; Dogs; Drug Synergism; Electroencephalography; Ethylketocyclazocine; Evoked Potentials; Female; Fentanyl; Morphine; Naloxone; Naltrexone; Reaction Time; Reflex; Reflex, Pupillary

1985
Effect of beta-funaltrexamine on opioid side-effects produced by morphine and U-50, 488H.
    The Journal of pharmacy and pharmacology, 1985, Volume: 37, Issue:11

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Body Temperature; Depression, Chemical; Dose-Response Relationship, Drug; Gastrointestinal Motility; Hypnotics and Sedatives; Male; Morphine; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rats; Rats, Inbred Strains; Respiration

1985
Chronic desipramine attenuates morphine analgesia.
    Pharmacology, biochemistry, and behavior, 1986, Volume: 24, Issue:1

    Topics: Analgesics, Opioid; Animals; Desipramine; Drug Interactions; Male; Mice; Morphine; Naloxone; Naltrexone; Propranolol; Reaction Time

1986
[3H]dynorphin A binding and kappa selectivity of prodynorphin peptides in rat, guinea-pig and monkey brain.
    European journal of pharmacology, 1986, Mar-04, Volume: 121, Issue:3

    Topics: Alkylating Agents; Animals; Benzomorphans; Brain Chemistry; Dynorphins; Guinea Pigs; In Vitro Techniques; Macaca mulatta; Morphine; Naltrexone; Peptides; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stereoisomerism

1986
Binaltorphimine and nor-binaltorphimine, potent and selective kappa-opioid receptor antagonists.
    Life sciences, 1987, Mar-30, Volume: 40, Issue:13

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Chemical Phenomena; Chemistry; Cyclazocine; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Male; Mice; Morphine; Naloxone; Naltrexone; Pyrrolidines; Rabbits; Receptors, Opioid; Receptors, Opioid, kappa

1987
An investigation of tolerance to the actions of leptogenic and anorexigenic drugs in mice.
    Life sciences, 1987, Nov-02, Volume: 41, Issue:18

    Topics: Amphetamine; Animals; Appetite Depressants; Body Weight; Calcitonin; Dextroamphetamine; Drug Tolerance; Eating; Fluoxetine; Mice; Morphine; Naltrexone; Neurotransmitter Agents

1987
Evidence for a peripheral action of thyrotropin releasing hormone on gastrointestinal transit in mice.
    Neuropharmacology, 1988, Volume: 27, Issue:4

    Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Drug Synergism; Gastrointestinal Transit; Loperamide; Male; Mice; Mice, Inbred Strains; Morphine; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Thiazolidines; Thyrotropin-Releasing Hormone

1988
Pharmacological evidence of a central effect of naltrexone, morphine, and beta-endorphin and a peripheral effect of met- and leu-enkephalin on retention of an inhibitory response in mice.
    Behavioral and neural biology, 1985, Volume: 44, Issue:3

    Topics: Adrenal Medulla; Animals; Avoidance Learning; beta-Endorphin; Brain; Drug Interactions; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Male; Memory; Mice; Morphine; Naltrexone; Quaternary Ammonium Compounds; Retention, Psychology

1985
High dose of spinal morphine produce a nonopiate receptor-mediated hyperesthesia: clinical and theoretic implications.
    Anesthesiology, 1986, Volume: 64, Issue:5

    Topics: Anesthesia, Spinal; Animals; Blood Pressure; Cats; Drug Tolerance; Fentanyl; Hyperesthesia; Methadone; Morphine; Morphine Derivatives; Naltrexone; Rats; Receptors, Drug; Stimulation, Chemical; Strychnine; Sufentanil; Sulfates; Touch

1986
The concentration of arginine vasopressin in pituitary stalk plasma of the rat after adrenalectomy or morphine.
    Endocrinology, 1986, Volume: 118, Issue:6

    Topics: Adrenalectomy; Animals; Arginine Vasopressin; beta-Endorphin; Dexamethasone; Endorphins; Male; Morphine; Naltrexone; Pituitary Gland; Portal System; Rats; Rats, Inbred Strains

1986
Morphine or capsaicin administration alters the secretion of beta-endorphin into the hypophysial portal vasculature of the rat.
    Neuroendocrinology, 1986, Volume: 43, Issue:5

    Topics: Animals; beta-Endorphin; Capsaicin; Endorphins; Hypophysectomy; Male; Morphine; Naltrexone; Pituitary Gland; Portal System; Radioimmunoassay; Rats; Rats, Inbred Strains

1986
Intrathecal beta-funaltrexamine antagonizes intracerebroventricular beta-endorphin- but not morphine-induced analgesia in mice.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 245, Issue:2

    Topics: Analgesia; Animals; beta-Endorphin; Cerebral Ventricles; Dose-Response Relationship, Drug; Injections, Intraventricular; Injections, Spinal; Male; Mice; Models, Neurological; Morphine; Naltrexone; Narcotic Antagonists; Spinal Cord

1988
Comparisons of descending pain inhibitory pathways activated by beta-endorphin and morphine as characterized by supraspinal and spinal antinociceptive interactions in mice.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 247, Issue:3

    Topics: Analgesia; Animals; beta-Endorphin; Drug Tolerance; Efferent Pathways; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Pain; Spinal Cord

1988
Neurochemical and functional correlates of naltrexone-induced opiate receptor up-regulation.
    The Journal of pharmacology and experimental therapeutics, 1985, Volume: 232, Issue:2

    Topics: Animals; Brain Chemistry; Guanosine Triphosphate; Male; Morphine; Naloxone; Naltrexone; Pain; Rats; Rats, Inbred Strains; Receptors, Opioid; Time Factors

1985
Opioid receptor binding characteristics of the non-equilibrium mu antagonist, beta-funaltrexamine (beta-FNA).
    European journal of pharmacology, 1985, Jan-08, Volume: 107, Issue:3

    Topics: Animals; Brain; Enkephalin, Methionine; In Vitro Techniques; Ligands; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tritium

1985
Effects of 5,5'-dithiobis-(2-nitrobenzoic acid) on opiate binding to both the membrane-bound receptor and the partially purified opiate receptor.
    Journal of neurochemistry, 1985, Volume: 45, Issue:2

    Topics: Animals; Butorphanol; Cell Membrane; Dihydromorphine; Diprenorphine; Dithionitrobenzoic Acid; Dithiothreitol; Etorphine; Morphine; Nalorphine; Naloxone; Naltrexone; Nitrobenzoates; Oxymorphone; Rats; Receptors, Opioid

1985
Plasma corticosterone changes in response to central or peripheral administration of kappa and sigma opiate agonists.
    The Journal of pharmacology and experimental therapeutics, 1985, Volume: 233, Issue:3

    Topics: Animals; Brain; Corticosterone; Cyclazocine; Ethylketocyclazocine; Humans; Hypothalamo-Hypophyseal System; Male; Morphine; Naloxone; Naltrexone; Opioid-Related Disorders; Phenazocine; Pituitary-Adrenal System; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, sigma

1985
Increased analgesic potency of morphine and increased brain opioid binding sites in the rat following chronic naltrexone treatment.
    Life sciences, 1985, Jun-17, Volume: 36, Issue:24

    Topics: Animals; Binding, Competitive; Brain; Drug Implants; Drug Interactions; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Morphine; Naloxone; Naltrexone; Pain; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Opioid; Time Factors

1985
Opiate antagonism reduces placentophagia and pup cleaning by parturient rats.
    Pharmacology, biochemistry, and behavior, 1985, Volume: 22, Issue:6

    Topics: Animals; Drug Tolerance; Feeding Behavior; Female; Labor, Obstetric; Maternal Behavior; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Placenta; Pregnancy; Rats; Rats, Inbred Strains; Receptors, Opioid; Time Factors

1985
Changes in responsiveness to mu and kappa opiates following a series of convulsions.
    Experimental neurology, 1985, Volume: 90, Issue:1

    Topics: Animals; Codeine; Dose-Response Relationship, Drug; Electroshock; Levorphanol; Mice; Mice, Inbred C57BL; Morphine; Naltrexone; Narcotics; Receptors, Opioid; Seizures

1985
Differential effects of morphine on the rates of dopamine turnover in the neural and intermediate lobes of the rat pituitary gland.
    Life sciences, 1985, Sep-30, Volume: 37, Issue:13

    Topics: alpha-Methyltyrosine; Animals; Dopamine; Kinetics; Male; Median Eminence; Methyltyrosines; Morphine; Naltrexone; Pituitary Gland; Pituitary Gland, Posterior; Rats; Receptors, Opioid

1985
Effect of mu and kappa opioid receptor agonists on rat plasma corticosterone levels.
    European journal of pharmacology, 1985, Oct-08, Volume: 116, Issue:1-2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Benzomorphans; Corticosterone; Dose-Response Relationship, Drug; Fentanyl; Male; Morphine; Naloxone; Naltrexone; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu

1985
Characterization of the discriminative stimulus effects of centrally administered morphine in the rat.
    Psychopharmacology, 1985, Volume: 87, Issue:1

    Topics: Animals; Discrimination Learning; Injections, Intraventricular; Injections, Subcutaneous; Male; Morphine; Naltrexone; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Receptors, Opioid

1985
N-(3-Fluoropropyl)-N-normetazocine, a potentially useful opiate antagonist for opiate receptor studies with positron emission tomography (PET).
    Research communications in chemical pathology and pharmacology, 1985, Volume: 49, Issue:3

    Topics: Analgesics; Animals; Binding, Competitive; Brain; Cyclazocine; Guinea Pigs; In Vitro Techniques; Male; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Structure-Activity Relationship; Tomography, Emission-Computed

1985
A radiolabeled-ligand-binding technique for the characterization of opioid receptors in the intact mouse vas deferens.
    Analytical biochemistry, 1985, Volume: 150, Issue:1

    Topics: Animals; Binding, Competitive; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; In Vitro Techniques; Kinetics; Male; Mice; Morphine; Naltrexone; Radioligand Assay; Receptors, Opioid; Vas Deferens

1985
Pharmacological evidence for a protective role of the endogenous opioid system on electroshock-induced seizures in the mouse.
    Neuroscience letters, 1985, Dec-04, Volume: 62, Issue:2

    Topics: Animals; Electroshock; Endorphins; Injections, Intraperitoneal; Male; Mice; Mice, Inbred C57BL; Morphine; Naloxone; Naltrexone; Receptors, Opioid; Seizures; Time Factors

1985
Inhibition of luteinizing hormone release by morphine and endogenous opiates in cultured pituitary cells.
    Endocrinology, 1986, Volume: 118, Issue:5

    Topics: Animals; beta-Endorphin; Cells, Cultured; Endorphins; Etorphine; Female; Gonadotropin-Releasing Hormone; Immunologic Techniques; Luteinizing Hormone; Morphine; Naltrexone; Pituitary Gland, Anterior; Rats; Receptors, Cell Surface; Receptors, LHRH; Receptors, Opioid

1986
An assessment of the role of opioid receptors in the response to cannabimimetic drugs.
    Journal of neurochemistry, 1986, Volume: 46, Issue:6

    Topics: Adenylyl Cyclase Inhibitors; Animals; Cannabinoids; Cell Line; Dronabinol; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Etorphine; Morphine; Naltrexone; Neuroblastoma; Neurons; Receptors, Opioid; Receptors, Opioid, delta

1986
Investigation of the structural requirements for the kappa-selective opioid receptor antagonist, 6 beta,6 beta'-[ethylenebis(oxyethyleneimino)]bis[17-(cyclopropylmethyl)- 4,5 alpha-epoxymorphinan-3,14-diol] (TENA).
    Journal of medicinal chemistry, 1986, Volume: 29, Issue:5

    Topics: Animals; Electric Stimulation; Guinea Pigs; Ileum; Morphine; Naltrexone; Receptors, Opioid; Structure-Activity Relationship

1986
Effects of endogenous and exogenous opioids on splenic natural killer cell activity.
    Natural immunity and cell growth regulation, 1986, Volume: 5, Issue:1

    Topics: Adrenocorticotropic Hormone; Animals; beta-Endorphin; Cytotoxicity Tests, Immunologic; Electric Stimulation; Endorphins; Female; Injections, Intraperitoneal; Killer Cells, Natural; Male; Mice; Mice, Inbred Strains; Morphine; Naloxone; Naltrexone; Poly I-C; Spleen

1986
Behavioral effects of opioid peptides selective for mu or delta receptors. I. Morphine-like discriminative stimulus effects.
    The Journal of pharmacology and experimental therapeutics, 1986, Volume: 238, Issue:3

    Topics: Animals; beta-Endorphin; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Discrimination Learning; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Morphine; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu

1986
Synthesis and opioid antagonist potencies of naltrexamine bivalent ligands with conformationally restricted spacers.
    Journal of medicinal chemistry, 1986, Volume: 29, Issue:9

    Topics: Animals; Biological Assay; Chemical Phenomena; Chemistry; Cyclazocine; Endorphins; Ethylketocyclazocine; Guinea Pigs; Ileum; Molecular Conformation; Morphine; Muscle Contraction; Naltrexone; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship

1986
Involvement of brain opiate receptors in the immune-suppressive effect of morphine.
    Proceedings of the National Academy of Sciences of the United States of America, 1986, Volume: 83, Issue:18

    Topics: Animals; Brain; Cytotoxicity, Immunologic; Immunosuppressive Agents; Killer Cells, Natural; Male; Morphine; Naltrexone; Rats; Rats, Inbred F344; Receptors, Opioid

1986
beta-Funaltrexamine (beta-FNA) and the regulation of body and brain development in rats.
    Brain research bulletin, 1986, Volume: 17, Issue:1

    Topics: Animals; Body Weight; Brain; Cerebellum; Female; Male; Morphine; Naltrexone; Nociceptors; Rats; Rats, Inbred Strains; Receptors, Opioid

1986
Pharmacodynamic supersensitivity and opioid receptor upregulation in the mouse.
    The Journal of pharmacology and experimental therapeutics, 1986, Volume: 239, Issue:1

    Topics: Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Lethal Dose 50; Male; Mice; Morphine; Naltrexone; Receptors, Opioid; Time Factors

1986
Irreversible blockage of opioid receptor types by ester homologues of beta-funaltrexamine.
    Journal of medicinal chemistry, 1986, Volume: 29, Issue:10

    Topics: Animals; Dihydromorphine; In Vitro Techniques; Morphine; Naltrexone; Narcotic Antagonists; Rats; Receptors, Opioid; Receptors, Opioid, mu; Structure-Activity Relationship

1986
Effects of the affinity ligands 14-beta-chloroacetylnaltrexone and 14-beta-bromoacetamidomorphine on [3H]-dihydromorphine binding sites in rat brain.
    Biochemical pharmacology, 1986, Nov-15, Volume: 35, Issue:22

    Topics: Animals; Brain; Dihydromorphine; In Vitro Techniques; Ligands; Male; Morphine; Morphine Derivatives; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Tritium

1986
Use of beta-funaltrexamine to determine mu opioid receptor involvement in the analgesic activity of various opioid ligands.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 241, Issue:2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Biological Assay; Buprenorphine; Butorphanol; Cyclazocine; Dose-Response Relationship, Drug; Ethylketocyclazocine; Etorphine; Fentanyl; Methadone; Mice; Morphine; Muscle Contraction; Nalbuphine; Nalorphine; Naltrexone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, mu

1987
Naltrexone reverses a long term depressive effect of a toxic lithium injection on saccharin preference.
    Physiology & behavior, 1987, Volume: 39, Issue:4

    Topics: Animals; Chlorides; Female; Lithium; Lithium Chloride; Morphine; Naltrexone; Rats; Rats, Inbred Strains; Saccharin; Taste

1987
Multiple interconvertible affinity states for the delta opioid agonist-receptor complex.
    The Journal of biological chemistry, 1987, Jul-05, Volume: 262, Issue:19

    Topics: Animals; Cattle; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylmaleimide; Guanylyl Imidodiphosphate; Hippocampus; Kinetics; Morphine; Naltrexone; Receptors, Opioid; Receptors, Opioid, delta; Synaptic Membranes

1987
Effects of restraint and naltrexone on the biphasic heart rate response to morphine in rats.
    Alcohol and drug research, 1987, Volume: 7, Issue:5-6

    Topics: Animals; Bradycardia; Heart Rate; Male; Morphine; Naltrexone; Rats; Receptors, Opioid; Restraint, Physical; Tachycardia; Time Factors

1987
An analysis of the paradoxical effect of morphine on runway speed and food consumption.
    Psychopharmacology, 1986, Volume: 89, Issue:3

    Topics: Animals; Avoidance Learning; Feeding Behavior; Food Deprivation; Male; Morphine; Motivation; Naltrexone; Nervous System; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Reward; Taste; Tegmentum Mesencephali

1986
Beta-funaltrexamine antagonizes the discriminative stimulus effects of morphine but not naltrexone in pigeons.
    Psychopharmacology, 1987, Volume: 91, Issue:2

    Topics: Animals; Columbidae; Discrimination, Psychological; Dose-Response Relationship, Drug; Morphine; Naltrexone

1987
Analgesia and decrement in operant performance in socially defeated mice: selective cross-tolerance to morphine and antagonism by naltrexone.
    Psychopharmacology, 1987, Volume: 92, Issue:4

    Topics: Aggression; Analgesia; Animals; Conditioning, Operant; Drug Tolerance; Male; Mice; Mice, Inbred Strains; Morphine; Naltrexone; Reaction Time; Reinforcement Schedule; Social Behavior

1987
Morphine induces delayed anorexia in rats.
    Psychopharmacology, 1988, Volume: 94, Issue:2

    Topics: Animals; Feeding Behavior; Gastrointestinal Contents; Male; Morphine; Naltrexone; Organ Size; Rats; Time Factors

1988
Dissociation of the opioid and nonopioid effects of cyclazocine.
    Pharmacology, biochemistry, and behavior, 1988, Volume: 30, Issue:1

    Topics: Animals; Cyclazocine; Dose-Response Relationship, Drug; Electroencephalography; Female; Hallucinogens; Morphine; Morphine Dependence; Naltrexone; Narcotics; Rats; Rats, Inbred Strains; Stereoisomerism

1988
Stress- and morphine-induced elevations of plasma and tissue cholesterol in mice: reversal by naltrexone.
    Biochemical pharmacology, 1988, Oct-01, Volume: 37, Issue:19

    Topics: Animals; Aorta; Cholesterol; Female; Liver; Loperamide; Mice; Morphine; Naltrexone; Receptors, LDL; Stress, Physiological

1988
Behavioral evidence for cholecystokinin-opiate interactions in neonatal rats.
    The American journal of physiology, 1988, Volume: 255, Issue:6 Pt 2

    Topics: Animals; Animals, Newborn; Cholecystokinin; Drug Interactions; Morphine; Motor Activity; Naltrexone; Pain; Rats; Rats, Inbred Strains; Reference Values; Sincalide; Stress, Psychological; Vocalization, Animal

1988
Clonidine activates a cholinergic hippocampal theta rhythm in the rat.
    Proceedings of the Western Pharmacology Society, 1988, Volume: 31

    Topics: Animals; Clonidine; Electroencephalography; Hippocampus; Male; Morphine; Naltrexone; Rats; Rats, Inbred Strains; Reference Values; Scopolamine; Theta Rhythm; Yohimbine

1988
Morphine preexposure attenuates the aversive properties of opiates without preexposure to the aversive properties.
    Pharmacology, biochemistry, and behavior, 1988, Volume: 30, Issue:3

    Topics: Animals; Conditioning, Psychological; Male; Morphine; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Reference Values; Saccharin; Taste

1988
Comparison of the oxytocin response to water-deprivation, hyperosmolarity and administration of morphine or naltrexone in lactating and virgin female rats.
    Neuroscience letters, 1988, Nov-22, Volume: 94, Issue:1-2

    Topics: Animals; Female; Lactation; Morphine; Naltrexone; Oxytocin; Pregnancy; Rats; Reference Values; Saline Solution, Hypertonic; Water Deprivation

1988
Morphine effects on locus ceruleus neurons are dependent on the state of arousal and availability of external stimuli: studies in anesthetized and unanesthetized rats.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 244, Issue:3

    Topics: Anesthesia; Animals; Arousal; Electric Stimulation; Locus Coeruleus; Male; Morphine; Naltrexone; Rats; Rats, Inbred Strains

1988
Neonatal naltrexone treatment: effects on sexual and exploratory behavior in male and female rats.
    Pharmacology, biochemistry, and behavior, 1988, Volume: 31, Issue:1

    Topics: Animals; Animals, Newborn; Copulation; Exploratory Behavior; Female; Male; Morphine; Naltrexone; Posture; Rats; Sex Factors; Sexual Behavior, Animal

1988
Kappa opioids in rhesus monkeys. II. Analysis of the antagonistic actions of quadazocine and beta-funaltrexamine.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 242, Issue:2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Azocines; Benzomorphans; Cyclazocine; Diuresis; Endorphins; Ethylketocyclazocine; Female; Hot Temperature; Macaca mulatta; Male; Morphine; Naltrexone; Narcotic Antagonists; Pyrrolidines; Reaction Time; Tail

1987
Evidence for the delivery of narcotic antagonists to the colon as their glucuronide conjugates.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 244, Issue:1

    Topics: Animals; Colon; Constipation; Diarrhea; Dose-Response Relationship, Drug; Glucuronates; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Skin Temperature; Substance-Related Disorders

1988
Differential antagonism by naltrexone of the effects of opioids on a fixed-ratio discrimination in rats.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 244, Issue:1

    Topics: Animals; Conditioning, Operant; Cyclazocine; Discrimination Learning; Dose-Response Relationship, Drug; Ethylketocyclazocine; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Pentazocine; Rats

1988
Pharmacology of the allodynia in rats evoked by high dose intrathecal morphine.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 244, Issue:2

    Topics: Analgesia; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Injections, Spinal; Morphine; Naltrexone; Pain; Rats; Spinal Cord; Structure-Activity Relationship; Strychnine

1988
Acute supersensitivity to the discriminative stimulus effects of naltrexone in pigeons.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 244, Issue:2

    Topics: Animals; Binding Sites; Columbidae; Diprenorphine; Discrimination Learning; Dose-Response Relationship, Drug; Generalization, Stimulus; Morphine; Nalorphine; Naloxone; Naltrexone; Opioid-Related Disorders

1988
Protection by opioids against gastric lesions caused by necrotizing agents.
    Pharmacology, 1988, Volume: 36, Issue:2

    Topics: Animals; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Endorphins; Gastric Mucosa; Hydrochloric Acid; Male; Morphine; Naltrexone; Rats; Rats, Inbred Strains; Sodium Hydroxide; Stomach Ulcer

1988
Effect of morphine and nalmefene on energy balance in diabetic and non-diabetic rats.
    Pharmacology, biochemistry, and behavior, 1988, Volume: 29, Issue:3

    Topics: Animals; Body Weight; Diabetes Mellitus, Experimental; Eating; Energy Metabolism; Male; Morphine; Naltrexone; Rats; Rats, Inbred Strains

1988
Comparative evaluation of different pathways for the liver toxicity of morphine using freshly isolated hepatocytes.
    Biochemical pharmacology, 1988, Jul-15, Volume: 37, Issue:14

    Topics: Animals; Glutathione; Liver; Male; Metyrapone; Morphine; Naloxone; Naltrexone; Rats; Rats, Inbred Strains

1988
Irreversible binding of [3H]beta-funaltrexamine to brain slices of morphine-tolerant and -dependent mice.
    European journal of pharmacology, 1988, May-10, Volume: 149, Issue:3

    Topics: Animals; Brain Chemistry; Corpus Striatum; Drug Tolerance; In Vitro Techniques; Male; Mesencephalon; Mice; Morphine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Stereoisomerism

1988
Evidence for the involvement of central opioidergic systems in L-tyrosine methyl ester-induced analgesia in the rat.
    Pharmacology, 1988, Volume: 37, Issue:1

    Topics: Analgesia; Animals; Endorphins; Injections, Intraventricular; Injections, Subcutaneous; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Tyrosine

1988
Chronic antagonist infusion does not increase morphine antinociception in rat spinal cord.
    Brain research, 1987, Nov-10, Volume: 425, Issue:2

    Topics: Animals; Injections, Spinal; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Rats; Rats, Inbred Strains; Spinal Cord

1987
Effects of a single administration of morphine or footshock stress on natural killer cell cytotoxicity.
    Brain, behavior, and immunity, 1987, Volume: 1, Issue:4

    Topics: Animals; Cytotoxicity, Immunologic; Electroshock; Female; Immunosuppression Therapy; Killer Cells, Natural; Morphine; Naltrexone; Rats; Rats, Inbred F344; Spleen; Stress, Physiological

1987
Endogenous opioids and post-ictal increase in seizure threshold in Mongolian gerbils.
    Epilepsy research, 1987, Volume: 1, Issue:2

    Topics: Animals; Electric Stimulation; Endorphins; Gerbillinae; Morphine; Naloxone; Naltrexone; Pentylenetetrazole; Seizures

1987
Variable-interval schedules of timeout from avoidance: effects of chlordiazepoxide, CGS 8216, morphine, and naltrexone.
    Journal of the experimental analysis of behavior, 1987, Volume: 47, Issue:1

    Topics: Animals; Avoidance Learning; Chlordiazepoxide; Conditioning, Operant; Male; Morphine; Naltrexone; Pyrazoles; Rats; Rats, Inbred Strains; Reinforcement Schedule

1987
Sensitization to repeated morphine injection in the rat: possible involvement of A10 dopamine neurons.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 241, Issue:1

    Topics: Animals; Dopamine; Male; Morphine; Motor Activity; Naltrexone; Neurons; Nucleus Accumbens; Rats; Rats, Inbred Strains; Tegmentum Mesencephali; Tissue Distribution

1987
[Effects of the opiate antagonists naloxone and naltrexone on the body temperature of rats].
    Eksperimentalna meditsina i morfologiia, 1987, Volume: 26, Issue:1

    Topics: Animals; Body Temperature; Dose-Response Relationship, Drug; Drug Interactions; Male; Morphine; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Time Factors

1987
Comparison of naltrexone and quaternary naltrexone after systemic and intracerebroventricular administration in pigeons.
    Neuropharmacology, 1987, Volume: 26, Issue:6

    Topics: Animals; Columbidae; Discrimination Learning; Injections, Intramuscular; Injections, Intraventricular; Morphine; Naltrexone; Quaternary Ammonium Compounds; Reinforcement Schedule

1987
Morphine, saline and naltrexone discrimination in morphine-treated pigeons.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 242, Issue:1

    Topics: Animals; Columbidae; Discrimination Learning; Dose-Response Relationship, Drug; Drug Interactions; Morphine; Naltrexone; Sodium Chloride

1987
Nitrous oxide-induced hypothermia in the rat.
    Life sciences, 1987, Aug-10, Volume: 41, Issue:6

    Topics: Animals; Body Temperature; Chloral Hydrate; Dose-Response Relationship, Drug; Drug Tolerance; Kinetics; Male; Morphine; Naloxone; Naltrexone; Nitrous Oxide; Rats

1987
The role of endogenous opioids in footshock-induced hyperthermia.
    Pharmacology, biochemistry, and behavior, 1987, Volume: 28, Issue:1

    Topics: Animals; Body Temperature Regulation; Drug Tolerance; Electroshock; Endorphins; Fever; Male; Morphine; Naltrexone; Rats; Rats, Inbred Strains; Stress, Physiological

1987
Antagonism by nalmefene of systemic and intrathecal morphine-induced analgesia in mice.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1987, Volume: 186, Issue:2

    Topics: Analgesia; Animals; Injections, Intravenous; Injections, Spinal; Male; Mice; Morphine; Naloxone; Naltrexone; Time Factors

1987
Is the motivational effect of opiate withdrawal reflected by common somatic indices of precipitated withdrawal? A place conditioning study in the rat.
    Brain research, 1987, Aug-25, Volume: 418, Issue:2

    Topics: Animals; Avoidance Learning; Behavior, Animal; Body Weight; Dose-Response Relationship, Drug; Drug Implants; Male; Morphine; Motivation; Naltrexone; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome

1987
Evidence for a central but not adrenal, opioid mediation in hypertension induced by brief isolation in the rat.
    Life sciences, 1986, May-26, Volume: 38, Issue:21

    Topics: Adrenalectomy; Animals; Blood Pressure; Corticosterone; Endorphins; Gastrointestinal Motility; Male; Morphine; Nalorphine; Naloxone; Naltrexone; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Social Isolation; Stress, Physiological

1986
Opioid-mediation of separation distress in 10-day-old rats: reversal of stress with maternal stimuli.
    Developmental psychobiology, 1986, Volume: 19, Issue:4

    Topics: Animals; Animals, Newborn; Brain; Endorphins; Female; Maternal Deprivation; Morphine; Naltrexone; Pain; Rats; Rats, Inbred Strains; Social Isolation; Vocalization, Animal

1986
Comparison of the effects of morphine and immobilization stress on discrimination performance of rats.
    Behavioral neuroscience, 1986, Volume: 100, Issue:4

    Topics: Animals; Arousal; Attention; Conditioning, Operant; Discrimination, Psychological; Electroshock; Male; Morphine; Naloxone; Naltrexone; Orientation; Psychomotor Performance; Rats; Rats, Inbred Strains; Restraint, Physical; Stress, Psychological

1986
Effect of morphine treatment and withdrawal on endogenous methionine- and leucine-enkephalin levels in primate brain.
    Biochemical pharmacology, 1986, Oct-01, Volume: 35, Issue:19

    Topics: Animals; Brain Chemistry; Chlorocebus aethiops; Enkephalin, Leucine; Enkephalin, Methionine; Female; Male; Morphine; Naltrexone; Substance Withdrawal Syndrome

1986
Pharmacologic and reinforcing properties of phencyclidine and the enantiomers of N-allylnormetazocine in the dog.
    Drug and alcohol dependence, 1986, Volume: 18, Issue:2

    Topics: Animals; Behavior, Animal; Conditioning, Operant; Decerebrate State; Dogs; Female; Morphine; Naltrexone; Phenazocine; Phencyclidine; Reinforcement Schedule; Self Administration; Stereoisomerism

1986
Loss of estradiol-positive feedback action on LH release during prepubertal period in rats treated postnatally with an opiate antagonist.
    Neuroendocrinology, 1986, Volume: 44, Issue:3

    Topics: Animals; Brain; Endorphins; Estradiol; Female; Luteinizing Hormone; Male; Morphine; Naltrexone; Orchiectomy; Ovariectomy; Rats; Rats, Inbred Strains; Sex Characteristics

1986
Ingestion of amniotic fluid enhances opiate analgesia in rats.
    Physiology & behavior, 1986, Volume: 38, Issue:6

    Topics: Amniotic Fluid; Analgesia; Animals; Endorphins; Female; Labor, Obstetric; Morphine; Naltrexone; Placenta; Pregnancy; Rats

1986
[Naloxone and naltrexone antagonism of various central effects of morphine].
    Bollettino della Societa italiana di biologia sperimentale, 1986, Oct-30, Volume: 62, Issue:10

    Topics: Animals; Behavior, Animal; Central Nervous System; Female; Male; Mice; Morphine; Naloxone; Naltrexone; Pain Measurement; Rats; Substance Withdrawal Syndrome

1986
Antinociceptive models displaying peripheral opioid activity.
    International journal of tissue reactions, 1985, Volume: 7, Issue:1

    Topics: Analgesics; Animals; Carrageenan; Codeine; Dextropropoxyphene; Dose-Response Relationship, Drug; Epoprostenol; Female; Indomethacin; Mice; Morphine; Movement; Nalorphine; Naloxone; Naltrexone; Narcotic Antagonists

1985
Direct inhibition of gonadotroph function by opiates.
    Transactions of the Association of American Physicians, 1985, Volume: 98

    Topics: Animals; Cells, Cultured; Female; Gonadotropin-Releasing Hormone; Luteinizing Hormone; Models, Biological; Morphine; Naltrexone; Pituitary Gland; Rats

1985
Effects of morphine, naltrexone, and dextrorphan in untreated and morphine-treated pigeons.
    Psychopharmacology, 1985, Volume: 85, Issue:3

    Topics: Animals; Behavior, Animal; Body Weight; Columbidae; Conditioning, Operant; Dextrorphan; Dose-Response Relationship, Drug; Drug Tolerance; Morphinans; Morphine; Naloxone; Naltrexone; Stereoisomerism

1985
Independent central and peripheral mediation of morphine-induced inhibition of gastrointestinal transit in rats.
    The Journal of pharmacology and experimental therapeutics, 1986, Volume: 236, Issue:1

    Topics: Analgesia; Animals; Brain; Gastrointestinal Motility; Injections, Intraventricular; Injections, Subcutaneous; Male; Morphine; Naloxone; Naltrexone; Peripheral Nerves; Rats; Rats, Inbred Strains

1986
Pharmacokinetics and pharmacodynamics of subcutaneous naltrexone pellets in the rat.
    The Journal of pharmacology and experimental therapeutics, 1986, Volume: 237, Issue:1

    Topics: Animals; Drug Implants; Kinetics; Male; Metabolic Clearance Rate; Morphine; Naltrexone; Rats

1986
Contralateral circling induced by tegmental morphine: anatomical localization, pharmacological specificity, and phenomenology.
    Brain research, 1985, Feb-04, Volume: 326, Issue:1

    Topics: Animals; Locomotion; Male; Morphine; Motor Activity; Muscimol; Naltrexone; Pimozide; Rats; Rotation; Substantia Nigra; Tegmentum Mesencephali

1985
Pharmacokinetics of morphine and its surrogates V: Naltrexone and naltrexone conjugate pharmacokinetics in the dog as a function of dose.
    Journal of pharmaceutical sciences, 1985, Volume: 74, Issue:1

    Topics: Animals; Bile; Body Fluids; Chromatography, High Pressure Liquid; Dogs; Kidney; Kinetics; Liver; Morphine; Naloxone; Naltrexone

1985
Morphine decreases 3H-norepinephrine release and increases endogenous norepinephrine levels in the isolated cat superior cervical ganglion.
    Life sciences, 1985, Apr-29, Volume: 36, Issue:17

    Topics: Acetylcholine; Animals; Autonomic Fibers, Preganglionic; Cats; Electric Stimulation; Female; Ganglia, Sympathetic; In Vitro Techniques; Male; Morphine; Naltrexone; Norepinephrine

1985
Hot-plate learning in mice is unaltered by immediate post-training administration of naloxone, naltrexone or morphine.
    Neuropharmacology, 1985, Volume: 24, Issue:4

    Topics: Animals; Endorphins; Hot Temperature; Learning; Male; Memory; Mice; Morphine; Naloxone; Naltrexone; Pain

1985
Chronic stress, aging and morphine analgesia: chronic stress affects the reactivity to morphine in young mature but not old rats.
    The Journal of pharmacology and experimental therapeutics, 1985, Volume: 233, Issue:3

    Topics: Age Factors; Aging; Analgesia; Analysis of Variance; Animals; Chronic Disease; Dose-Response Relationship, Drug; Male; Morphine; Naltrexone; Rats; Rats, Inbred Strains; Stress, Physiological; Time Factors

1985
Opiate agonist-antagonist interactions: application of a three-key drug discrimination procedure.
    The Journal of pharmacology and experimental therapeutics, 1985, Volume: 234, Issue:1

    Topics: Animals; Columbidae; Discrimination Learning; Dose-Response Relationship, Drug; Drug Interactions; Morphine; Naltrexone; Narcotic Antagonists; Narcotics

1985
Prolactin analgesia: tolerance and cross-tolerance with morphine.
    European journal of pharmacology, 1985, May-28, Volume: 112, Issue:1

    Topics: Analgesics; Animals; Bromocriptine; Drug Tolerance; Male; Mice; Morphine; Naltrexone; Prolactin

1985
Cross-tolerance between morphine- and bombesin-induced inhibition of intestinal transit in rats.
    European journal of pharmacology, 1985, Aug-15, Volume: 114, Issue:2

    Topics: Animals; Bombesin; Drug Tolerance; Gastrointestinal Motility; Male; Morphine; Naloxone; Naltrexone; Rats; Rats, Inbred Strains

1985
Effects of buprenorphine on shock titration in squirrel monkeys.
    The Journal of pharmacology and experimental therapeutics, 1985, Volume: 235, Issue:1

    Topics: Animals; Buprenorphine; Conditioning, Operant; Diprenorphine; Dose-Response Relationship, Drug; Drug Interactions; Electroshock; Male; Morphinans; Morphine; Naloxone; Naltrexone; Saimiri

1985
beta-Funaltrexamine (beta-FNA) and neural tumor response in mice.
    European journal of pharmacology, 1985, Oct-08, Volume: 116, Issue:1-2

    Topics: Animals; Male; Mice; Mice, Inbred A; Morphine; Naltrexone; Narcotic Antagonists; Neoplasm Transplantation; Neuroblastoma; Reaction Time

1985
Effects of beta-funaltrexamine in normal and morphine-dependent rhesus monkeys: observational studies.
    The Journal of pharmacology and experimental therapeutics, 1985, Volume: 235, Issue:2

    Topics: Animals; Azocines; Behavior, Animal; Dose-Response Relationship, Drug; Injections, Intraventricular; Injections, Subcutaneous; Macaca mulatta; Morphine; Muscle Relaxation; Naloxone; Naltrexone; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors

1985
Antagonistic and rate-suppressing effects of opioid antagonists in the pigeon.
    The Journal of pharmacology and experimental therapeutics, 1985, Volume: 235, Issue:2

    Topics: Animals; Azocines; Benzomorphans; Buprenorphine; Columbidae; Conditioning, Operant; Diprenorphine; Dose-Response Relationship, Drug; Morphine; Naloxone; Naltrexone; Narcotic Antagonists

1985
Clinical evaluation of a naltrexone sustained-release preparation.
    Drug and alcohol dependence, 1985, Volume: 16, Issue:1

    Topics: Delayed-Action Preparations; Drug Evaluation; Drug Implants; Humans; Injections, Intravenous; Kinetics; Male; Morphine; Naltrexone; Time Factors

1985
Intraseptal morphine potentiates pentobarbital narcosis and hypothermia in the rat.
    Pharmacology, biochemistry, and behavior, 1985, Volume: 23, Issue:4

    Topics: Anesthesia; Animals; Body Temperature; Cerebral Cortex; Drug Synergism; Injections; Male; Morphine; Naltrexone; Pentobarbital; Rats; Rats, Inbred Strains; Sleep; Time Factors

1985
Quaternary naltrexone reverses morphine-induced behaviors.
    Physiology & behavior, 1985, Volume: 35, Issue:2

    Topics: Animals; Behavior, Animal; Locomotion; Male; Mice; Mice, Inbred C57BL; Morphine; Naltrexone; Quaternary Ammonium Compounds

1985
Placenta ingestion enhances opiate analgesia in rats.
    Physiology & behavior, 1985, Volume: 35, Issue:4

    Topics: Analgesia; Animals; Diet; Electroshock; Female; Maternal Behavior; Morphine; Naltrexone; Pain; Placenta; Pregnancy; Rats; Sensory Thresholds

1985
Acute effects of morphine on neurochemical estimates of activity of incertohypothalamic dopaminergic neurons in the male rat.
    Brain research, 1985, Dec-02, Volume: 348, Issue:2

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Dopamine; Electrochemistry; Hypothalamus; Male; Methyltyrosines; Morphine; Naltrexone; Neural Pathways; Neurons; Rats; Rats, Inbred Strains; Time Factors

1985
Intracerebroventricular drug administration in pigeons.
    Pharmacology, biochemistry, and behavior, 1985, Volume: 23, Issue:5

    Topics: Animals; Columbidae; Conditioning, Operant; Dose-Response Relationship, Drug; Injections, Intramuscular; Injections, Intraventricular; Morphine; Naloxone; Naltrexone; Pharmaceutical Preparations

1985
Neonatal exposure to naltrexone affects morphine sensitivity and facilitates sexual behaviour in female rats.
    Neuroscience letters, 1985, Dec-18, Volume: 62, Issue:3

    Topics: Animals; Animals, Newborn; Copulation; Female; Morphine; Naltrexone; Posture; Rats; Rats, Inbred Strains; Sexual Behavior, Animal; Time Factors

1985
Stereospecificity of 4,5-epoxymorphinan binding to the lambda site in rat brain.
    European journal of pharmacology, 1984, May-18, Volume: 101, Issue:1-2

    Topics: Animals; Binding, Competitive; Brain; In Vitro Techniques; Male; Morphinans; Morphine; Naloxone; Naltrexone; Narcotics; Oxymorphone; Rats; Rats, Inbred Strains; Receptors, Opioid; Stereoisomerism

1984
Duration of opiate receptor blockade determines tumorigenic response in mice with neuroblastoma: a role for endogenous opioid systems in cancer.
    Life sciences, 1984, Jul-23, Volume: 35, Issue:4

    Topics: Analgesia; Animals; Cell Line; Male; Mice; Mice, Inbred Strains; Morphine; Naloxone; Naltrexone; Neuroblastoma; Receptors, Opioid

1984
Design and synthesis of naltrexone-derived affinity labels with nonequilibrium opioid agonist and antagonist activities. Evidence for the existence of different mu receptor subtypes in different tissues.
    Journal of medicinal chemistry, 1984, Volume: 27, Issue:10

    Topics: Affinity Labels; Animals; Chemical Phenomena; Chemistry; Guinea Pigs; Ileum; Indicators and Reagents; Kinetics; Magnetic Resonance Spectroscopy; Male; Mice; Morphine; Muscle, Smooth; Naloxone; Naltrexone; Receptors, Opioid; Receptors, Opioid, mu; Structure-Activity Relationship; Vas Deferens

1984
Enhancement of opiate-induced depressions in serum luteinizing hormone levels by the prior administration of naloxone in the male rat.
    Life sciences, 1984, Sep-17, Volume: 35, Issue:12

    Topics: Animals; Binding, Competitive; Brain; Dose-Response Relationship, Drug; Gonadotropin-Releasing Hormone; Kinetics; Luteinizing Hormone; Male; Morphine; Naloxone; Naltrexone; Narcotics; Rats; Rats, Inbred Strains; Receptors, Opioid

1984
Counteraction by naltrexone of stress-induced inhibition of TSH release: role of noradrenergic system.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1984, Volume: 177, Issue:2

    Topics: Animals; Ditiocarb; Kinetics; Male; Morphine; Naloxone; Naltrexone; Norepinephrine; Pituitary Gland, Anterior; Rats; Rats, Inbred Strains; Stress, Physiological; Thyrotropin

1984
Role of spinal mu opioid receptors in the development of morphine tolerance and dependence.
    The Journal of pharmacology and experimental therapeutics, 1984, Volume: 231, Issue:1

    Topics: Analgesia; Animals; Body Weight; Drug Tolerance; Humans; Male; Morphine; Morphine Dependence; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Spinal Cord

1984
Hyperthermic response of the cat to intraventricular injection of the opioid delta-receptor agonist D-Ala2-D-Leu5-enkephalin.
    Brain research bulletin, 1984, Volume: 13, Issue:2

    Topics: Animals; Body Temperature; Body Temperature Regulation; Cats; Drug Tolerance; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Injections, Intraventricular; Morphine; Naloxone; Naltrexone; Receptors, Opioid; Receptors, Opioid, delta

1984
Comparative antagonism by naltrexone and naloxone of mu, kappa, and delta agonists.
    European journal of pharmacology, 1984, Sep-03, Volume: 104, Issue:1-2

    Topics: Animals; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vas Deferens

1984
Effects of naltrexone and prolyl-leucyl-glycinamide on drug-induced tremor and rigidity in the rat.
    Neuropharmacology, 1981, Volume: 20, Issue:8

    Topics: Animals; Female; Injections, Intraventricular; Morphine; MSH Release-Inhibiting Hormone; Muscle Rigidity; Muscle Tonus; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Time Factors; Tremor; Tremorine

1981
Pharmacological characterization in vivo of the novel opiate, beta-funaltrexamine.
    The Journal of pharmacology and experimental therapeutics, 1982, Volume: 220, Issue:3

    Topics: Acetates; Acetic Acid; Analgesics, Opioid; Animals; Drug Interactions; Female; Male; Mice; Morphine; Nalorphine; Naloxone; Naltrexone; Narcotics; Pain; Reaction Time

1982
Evidence for a role of the ventro-medial posterior hypothalamus in nociceptive processes in the rat.
    Pharmacology, biochemistry, and behavior, 1983, Volume: 18, Issue:6

    Topics: Animals; beta-Endorphin; Dynorphins; Electroshock; Endorphins; Enkephalin, Methionine; Hypothalamus; Hypothalamus, Posterior; Male; Morphine; Naltrexone; Nociceptors; Pain; Protein Precursors; Rats; Rats, Inbred Strains; Stereotaxic Techniques

1983
Opioid peptides and seizures in the spontaneously epileptic Mongolian gerbil.
    Life sciences, 1983, Volume: 33 Suppl 1

    Topics: Animals; beta-Endorphin; Cerebral Cortex; Dynorphins; Endorphins; Enkephalin, Methionine; Epilepsy; Gerbillinae; Morphine; Naltrexone; Narcotics; Seizures

1983
Is the hypothermic effect of alpha-methyldopa mediated by opioid peptides?
    The Journal of pharmacy and pharmacology, 1984, Volume: 36, Issue:7

    Topics: Animals; Body Temperature; Endorphins; Male; Methyldopa; Morphine; Naltrexone; Rats; Rats, Inbred Strains

1984
Morphine analgesia after intrathecal administration of a narcotic agonist, chloroxymorphamine and antagonist, chlornaltrexamine.
    European journal of pharmacology, 1980, Nov-07, Volume: 68, Issue:1

    Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Interactions; Hydromorphone; Injections, Spinal; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Nitrogen Mustard Compounds; Oxymorphone; Rats

1980
Pharmacological studies with an alkylating narcotic agonist, chloroxymorphamine, and antagonist, chlornaltrexamine.
    The Journal of pharmacology and experimental therapeutics, 1980, Volume: 213, Issue:3

    Topics: Analgesics; Animals; Brain; Hydromorphone; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Nitrogen Mustard Compounds; Oxymorphone

1980
Effects of beta-endorphin and its fragments on inhibitory avoidance behavior in rats.
    Psychoneuroendocrinology, 1983, Volume: 8, Issue:4

    Topics: alpha-Endorphin; Animals; Avoidance Learning; beta-Endorphin; beta-Lipotropin; Dose-Response Relationship, Drug; Endorphins; gamma-Endorphin; Injections, Intraventricular; Injections, Subcutaneous; Male; Mental Recall; Morphine; Naltrexone; Nociceptors; Peptide Fragments; Rats; Rats, Inbred Strains; Reaction Time; Retention, Psychology

1983
Discriminative stimulus effects of reversible and irreversible opiate agonists: morphine, oxymorphazone and buprenorphine.
    The Journal of pharmacology and experimental therapeutics, 1984, Volume: 230, Issue:3

    Topics: Animals; Buprenorphine; Columbidae; Discrimination Learning; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Hydromorphone; Morphinans; Morphine; Naltrexone; Oxymorphone; Time Factors

1984
Irreversible and reversible narcotic agonists: discriminative and analgesic effects of buprenorphine, oxymorphazone, and morphine.
    NIDA research monograph, 1984, Volume: 49

    Topics: Animals; Buprenorphine; Columbidae; Discrimination Learning; Dose-Response Relationship, Drug; Hydromorphone; Mice; Morphinans; Morphine; Naltrexone; Nociceptors; Oxymorphone

1984
Selective protection of stereospecific enkephalin and opiate binding against inactivation by N-ethylmaleimide: evidence for two classes of opiate receptors.
    Proceedings of the National Academy of Sciences of the United States of America, 1980, Volume: 77, Issue:1

    Topics: Animals; Binding, Competitive; Brain; Endorphins; Enkephalins; Ethylmaleimide; Kinetics; Ligands; Male; Morphine; Naloxone; Naltrexone; Rats; Receptors, Opioid

1980
Effects of pentazocine and other opiates on shock detection in the rat: involvement of opiate and dopamine receptors.
    Psychopharmacology, 1980, Volume: 67, Issue:2

    Topics: Animals; Electroshock; Male; Morphine; Naltrexone; Narcotics; Pentazocine; Prejudice; Rats; Receptors, Dopamine; Receptors, Opioid; Reinforcement Schedule

1980
Opiate receptors: problems of definition and characterization.
    Advances in biochemical psychopharmacology, 1980, Volume: 21

    Topics: Animals; Binding Sites; Brain; Caudate Nucleus; Cyclazocine; Endorphins; Enkephalins; Hippocampus; Humans; Morphine; Naloxone; Naltrexone; Receptors, Opioid

1980
The effects of opiate agonists on growth hormone and prolactin release in rats.
    Federation proceedings, 1980, Volume: 39, Issue:8

    Topics: Animals; Apomorphine; Enkephalins; Growth Hormone; Male; Methadone; Morphine; Naloxone; Naltrexone; Parasympathomimetics; Prolactin; Rats; Receptors, Cholinergic; Receptors, Dopamine; Receptors, Opioid; Secretory Rate

1980
Location and characterization of opiate receptors regulating pituitary secretion.
    Life sciences, 1980, May-12, Volume: 26, Issue:19

    Topics: Animals; Apomorphine; Chromatography, Gel; Corpus Striatum; Endorphins; Enkephalins; Female; Growth Hormone; Hypothalamus; Luteinizing Hormone; Morphine; Naltrexone; Pituitary Gland, Anterior; Prolactin; Rats; Receptors, Opioid; Thyrotropin

1980
Possible role of an endogenous opiate in the cardiovascular effects of central alpha adrenoceptor stimulation in spontaneously hypertensive rats.
    The Journal of pharmacology and experimental therapeutics, 1980, Volume: 214, Issue:1

    Topics: Anesthesia; Animals; Blood Pressure; Clonidine; Dose-Response Relationship, Drug; Drug Interactions; Endorphins; Heart Rate; Hypertension; Male; Methyldopa; Morphine; Naloxone; Naltrexone; Rats; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Receptors, Opioid; Time Factors; Yohimbine

1980
Depressant and excitant effects of intraspinal microinjections of morphine and methionine-enkephalin in the cat.
    Brain research, 1980, Sep-08, Volume: 196, Issue:2

    Topics: Animals; Cats; Endorphins; Enkephalins; Evoked Potentials; Female; Ganglia, Spinal; Male; Morphine; Motor Neurons; Naltrexone; Nerve Fibers; Nociceptors; Reflex; Spinal Cord; Synapses; Synaptic Transmission

1980
Influence of morphine and naltrexone on the intraocular pressure of conscious cynomolgus monkeys (Macaca fascicularis).
    Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. Albrecht von Graefe's archive for clinical and experimental ophthalmology, 1980, Volume: 214, Issue:1

    Topics: Animals; Drug Combinations; Intraocular Pressure; Macaca; Macaca fascicularis; Morphine; Naloxone; Naltrexone; Receptors, Opioid

1980
Discriminative stimulus effects of prototype opiate receptor agonists in monkeys.
    European journal of pharmacology, 1980, Nov-07, Volume: 68, Issue:1

    Topics: Animals; Apomorphine; Cyclazocine; Ethylketocyclazocine; Female; Generalization, Stimulus; Haloperidol; Male; Models, Biological; Morphine; Naltrexone; Phenazocine; Prejudice; Receptors, Opioid; Saimiri

1980
Quaternary naltrexone: evidence for the central mediation of discriminative stimulus effects of narcotic agonists and antagonists.
    The Journal of pharmacology and experimental therapeutics, 1981, Volume: 217, Issue:3

    Topics: Animals; Brain; Columbidae; Discrimination, Psychological; Etorphine; Macaca mulatta; Male; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Receptors, Opioid

1981
Different opioid systems may participate in post-electro-convulsive shock (ECS) analgesia and catalepsy.
    Brain research, 1981, Aug-31, Volume: 219, Issue:2

    Topics: Animals; Drug Tolerance; Electroshock; Male; Morphine; Motor Activity; Naloxone; Naltrexone; Nociceptors; Rats; Receptors, Opioid

1981
Antagonism by chlornaltrexamine of some effects of delta 9-tetrahydrocannabinol in rats.
    European journal of pharmacology, 1981, Mar-12, Volume: 70, Issue:2

    Topics: Analgesia; Animals; Dronabinol; Drug Tolerance; Humans; Hypothermia; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Nitrogen Mustard Compounds; Rats; Receptors, Opioid; Substance-Related Disorders

1981
Seasonal variation in the apparent number of binding sites for 3H-opioid agonists and antagonists.
    Life sciences, 1981, Jun-08, Volume: 28, Issue:23

    Topics: Animals; Binding Sites; Brain; Dihydromorphine; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Kinetics; Male; Mice; Morphinans; Morphine; Naloxone; Naltrexone; Receptors, Opioid; Seasons

1981
In vivo receptor binding of the opiate partial agonist, buprenorphine, correlated with its agonistic and antagonistic actions.
    British journal of pharmacology, 1981, Volume: 74, Issue:3

    Topics: Analgesia; Animals; Brain; Buprenorphine; Dose-Response Relationship, Drug; Male; Morphinans; Morphine; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid

1981
Naltrexone improves survival rate and cardiovascular function in canine hemorrhagic shock.
    The Journal of pharmacology and experimental therapeutics, 1982, Volume: 220, Issue:3

    Topics: Animals; Dogs; Dose-Response Relationship, Drug; Drug Tolerance; Female; Hemodynamics; Male; Morphine; Naloxone; Naltrexone; Receptors, Opioid; Shock, Hemorrhagic

1982
Antagonism of morphine-induced behavioral suppression by opiate receptor alkylators.
    Pharmacology, biochemistry, and behavior, 1982, Volume: 16, Issue:4

    Topics: Amphetamine; Animals; Brain; Conditioning, Operant; Exploratory Behavior; Male; Morphine; Muridae; Naloxone; Naltrexone; Nitrogen Mustard Compounds; Nociceptors; Receptors, Opioid

1982
Stimulus properties of opioids with mixed agonist and antagonist activity.
    Federation proceedings, 1982, Volume: 41, Issue:7

    Topics: Animals; Conditioning, Psychological; Cyclazocine; Dogs; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Phencyclidine; Rats; Receptors, Opioid; Saimiri

1982
Interactions between narcotic agonists, partial agonists andd antagonists evaluated by punished an unpunished behavior in the rat.
    Psychopharmacology, 1982, Volume: 76, Issue:2

    Topics: Animals; Conditioning, Psychological; Cyclazocine; Dose-Response Relationship, Drug; Ethylketocyclazocine; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Phenazocine; Punishment; Rats; Rats, Inbred Strains; Receptors, Opioid

1982
Opiate, enkephalin, and endorphin analgesia: relations to a single subpopulation of opiate receptors.
    Neurology, 1981, Volume: 31, Issue:10

    Topics: Analgesia; Animals; Humans; Lethal Dose 50; Morphine; Muridae; Naloxone; Naltrexone; Oxymorphone; Receptors, Opioid; Respiration; Respiratory Insufficiency

1981
Release of prolactin in response to microinjection of morphine into mesencephalic dorsal raphe nucleus.
    Neuroendocrinology, 1982, Volume: 35, Issue:3

    Topics: Animals; Brain Stem; Female; Mesencephalon; Morphine; Naltrexone; Prolactin; Raphe Nuclei; Rats; Rats, Inbred Strains; Receptors, Opioid

1982
Intraseptally injected opiate agents: effects on morphine-induced behaviour of cats.
    Pharmacology, biochemistry, and behavior, 1982, Volume: 17, Issue:2

    Topics: Animals; Behavior, Animal; beta-Endorphin; Cats; Endorphins; Enkephalin, Methionine; Fentanyl; Morphine; Naloxone; Naltrexone; Narcotics; Receptors, Opioid; Septal Nuclei; Septum Pellucidum

1982
Extent and control of shock affects naltrexone sensitivity of stress-induced analgesia and reactivity to morphine.
    Pharmacology, biochemistry, and behavior, 1982, Volume: 17, Issue:5

    Topics: Animals; Dose-Response Relationship, Drug; Electroshock; Helplessness, Learned; Humans; Male; Morphine; Naloxone; Naltrexone; Nociceptors; Rats; Receptors, Opioid; Sensory Thresholds; Stress, Physiological

1982
Opiate and non-opiate aspects of morphine induced seizures.
    Brain research, 1982, Dec-16, Volume: 253, Issue:1-2

    Topics: Amygdala; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Evoked Potentials; Injections, Intraperitoneal; Kindling, Neurologic; Male; Morphine; Motor Activity; Muridae; Naltrexone; Nociceptors; Receptors, Opioid; Seizures

1982
Improved assays for the assessment of kappa- and delta-properties of opioid ligands.
    European journal of pharmacology, 1982, Nov-19, Volume: 85, Issue:2

    Topics: Animals; Cyclazocine; Ethylketocyclazocine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Vas Deferens

1982
Relative involvement of receptor subtypes in opioid-induced inhibition of gastrointestinal transit in mice.
    The Journal of pharmacology and experimental therapeutics, 1983, Volume: 224, Issue:2

    Topics: Animals; Charcoal; Cyclazocine; Drug Interactions; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Female; Gastrointestinal Motility; Male; Mice; Morphine; Nalorphine; Naltrexone; Receptors, Opioid

1983
Effects of opiate antagonists and putative mu- and kappa-agonists on milk intake in rat and squirrel monkey.
    Pharmacology, biochemistry, and behavior, 1982, Volume: 17, Issue:6

    Topics: Animals; Buprenorphine; Cyclazocine; Diazepam; Diprenorphine; Drinking; Ethylketocyclazocine; Etorphine; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Saimiri; Taste

1982
Analgesia induced by electroconvulsive shock: brain enkephalins may mediate tolerance but not the induction of analgesia.
    Brain research, 1983, Feb-07, Volume: 260, Issue:2

    Topics: Animals; Brain; Drug Tolerance; Electroshock; Enkephalins; Male; Morphine; Muridae; Naltrexone; Nociceptors; Receptors, Opioid; Sensory Thresholds; Synaptic Transmission

1983
Regulation of opiate receptors in mouse brain: arcuate nuclear lesion induces receptor up-regulation and supersensitivity to opiates.
    Brain research, 1983, Feb-28, Volume: 262, Issue:1

    Topics: Animals; Arcuate Nucleus of Hypothalamus; Brain; Cell Membrane; Dihydromorphine; Kinetics; Mesencephalon; Mice; Mice, Inbred ICR; Morphine; Morphine Derivatives; Naltrexone; Receptors, Opioid; Sodium Glutamate

1983
An opiate binding site in the rat brain is highly selective for 4,5-epoxymorphinans.
    Science (New York, N.Y.), 1983, Sep-16, Volume: 221, Issue:4616

    Topics: Animals; Brain Chemistry; Dihydromorphine; Diprenorphine; Morphine; Nalorphine; Naloxone; Naltrexone; Rats; Receptors, Opioid; Sodium; Tissue Distribution

1983
Naltrexone fails to antagonize the sigma effects of PCP and SKF 10,047 in the dog.
    European journal of pharmacology, 1983, Sep-02, Volume: 92, Issue:3-4

    Topics: Animals; Body Temperature; Dogs; Female; Heart Rate; Morphine; Naloxone; Naltrexone; Paraplegia; Phenazocine; Phencyclidine; Receptors, Opioid; Receptors, sigma; Reflex

1983
Morphine exacerbates anaphylactic shock in mice by stimulating central opiate receptors.
    Neuroscience letters, 1983, Sep-30, Volume: 40, Issue:2

    Topics: Anaphylaxis; Animals; Azocines; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Naltrexone; Receptors, Opioid

1983
Multi-dimensional analyses of behavior in mice treated with morphine, endorphins and [des-tyrosine1]-gamma-endorphin.
    Pharmacology, biochemistry, and behavior, 1983, Volume: 19, Issue:4

    Topics: Animals; Behavior, Animal; beta-Endorphin; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Injections, Intraventricular; Male; Mice; Morphine; Naltrexone; Peptide Fragments

1983
Chronic naltrexone increases opiate binding in brain and produces supersensitivity to morphine in the locus coeruleus of the rat.
    Brain research, 1983, Dec-19, Volume: 289, Issue:1-2

    Topics: Animals; Brain; Etorphine; Locus Coeruleus; Male; Morphine; Naloxone; Naltrexone; Narcotics; Neurons; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Synaptic Transmission; Yohimbine

1983
Evidence from opiate binding studies that heroin acts through its metabolites.
    Life sciences, 1983, Volume: 33 Suppl 1

    Topics: Animals; Brain; Cell Membrane; Heroin; Male; Morphine; Morphine Derivatives; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Structure-Activity Relationship

1983
Body temperature effects of opioids administered into the periaqueductal grey area of rat brain.
    Regulatory peptides, 1983, Volume: 7, Issue:3

    Topics: Animals; Body Temperature Regulation; Endorphins; Male; Morphine; Naltrexone; Periaqueductal Gray; Rats; Receptors, Opioid; Time Factors

1983
Nonspecific convulsions are induced by morphine but not D-Ala2-methionine-enkephalinamide at cortical sites.
    Brain research, 1984, May-07, Volume: 299, Issue:1

    Topics: Animals; Cerebral Cortex; Drug Tolerance; Electroencephalography; Enkephalin, Methionine; Evoked Potentials; Injections, Intraventricular; Male; Methadone; Morphine; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Seizures

1984
Endogenous opioids mediate ECS-induced catalepsy at supraspinal levels.
    Brain research, 1984, Jun-11, Volume: 303, Issue:1

    Topics: Animals; Brain; Catalepsy; Electroshock; Endorphins; Humans; Male; Morphine; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Seizures; Spinal Cord

1984
Differential role of the opioid mu and delta receptors in the activation of prolactin (PRL) and growth hormone (GH) secretion by morphine in the male rat.
    Life sciences, 1984, May-07, Volume: 34, Issue:19

    Topics: Animals; Drug Interactions; Enkephalin, Leucine; Growth Hormone; Injections, Intraventricular; Male; Morphine; Naloxone; Naltrexone; Prolactin; Rats; Rats, Inbred Strains; Receptors, Opioid

1984
Opioid antagonism of electroshock-induced seizures.
    Pharmacology, biochemistry, and behavior, 1984, Volume: 20, Issue:5

    Topics: Animals; beta-Endorphin; Electroshock; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Mice; Mice, Inbred C57BL; Morphine; Naltrexone; Narcotics; Seizures; Time Factors

1984
Endogenous opiate involvement in acute and chronic stress-induced changes in plasma LH concentrations in the male rat.
    Life sciences, 1984, Jun-18, Volume: 34, Issue:25

    Topics: Animals; Endorphins; Gonadotropin-Releasing Hormone; Luteinizing Hormone; Male; Morphine; Naltrexone; Rats; Rats, Inbred Strains; Starvation; Stress, Physiological

1984
Narcotic discrimination in pigeons: antagonism by naltrexone.
    European journal of pharmacology, 1984, Oct-01, Volume: 105, Issue:1-2

    Topics: Animals; Columbidae; Cyclazocine; Discrimination, Psychological; Dose-Response Relationship, Drug; Ethylketocyclazocine; Meperidine; Morphine; Naloxone; Naltrexone; Narcotics

1984
Predictors of favorable outcome following naltrexone treatment.
    NIDA research monograph, 1983, Volume: 43

    Topics: Employment; Humans; Morphine; Naloxone; Naltrexone; Opioid-Related Disorders; Time Factors

1983
Effects of b-FNA in drug-naive and morphine-dependent rhesus monkeys.
    NIDA research monograph, 1984, Volume: 55

    Topics: Animals; Macaca mulatta; Morphine; Naltrexone; Substance-Related Disorders; Time Factors

1984
Footshock induced hyperthermia.
    Proceedings of the Western Pharmacology Society, 1984, Volume: 27

    Topics: Animals; Drug Tolerance; Electroshock; Endorphins; Fever; Male; Morphine; Naltrexone; Rats; Rats, Inbred Strains; Stress, Physiological

1984
Locomotor activity and opiate effects in male and female hamsters.
    Pharmacology, biochemistry, and behavior, 1984, Volume: 21, Issue:3

    Topics: Analysis of Variance; Animals; Cricetinae; Female; Male; Mesocricetus; Morphine; Motor Activity; Naltrexone; Narcotics; Sex Factors

1984
Stress induced alteration of opiate withdrawal.
    Drug and alcohol dependence, 1984, Volume: 13, Issue:3

    Topics: Animals; Body Weight; Humans; Male; Morphine; Naltrexone; Rats; Rats, Inbred Strains; Stress, Physiological; Substance Withdrawal Syndrome

1984
Endogenous opiates and stress. Behavioral activation elicited in the rat and effects of naltrexone, diprenorphine and morphine.
    Neuropharmacology, 1984, Volume: 23, Issue:12A

    Topics: Animals; Behavior, Animal; Diprenorphine; Endorphins; Humans; Male; Morphinans; Morphine; Naloxone; Naltrexone; Noise; Rats; Rats, Inbred Strains; Receptors, Drug; Stress, Psychological; Time Factors

1984
The effects of intrathecal morphine and naltrexone on autotomy in sciatic nerve sectioned rats.
    Pain, 1984, Volume: 18, Issue:3

    Topics: Animals; Behavior, Animal; Differential Threshold; Disease Models, Animal; Injections, Spinal; Male; Morphine; Naloxone; Naltrexone; Nociceptors; Pain; Rats; Rats, Inbred Strains; Sciatic Nerve; Time Factors

1984
Endorphins in endotoxin-induced hyperglycemia in mice.
    Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement, 1983, Volume: 6

    Topics: Animals; Endorphins; Endotoxins; Hyperglycemia; Male; Mice; Mice, Inbred C3H; Morphine; Naloxone; Naltrexone; Quaternary Ammonium Compounds

1983
An antiabsorptive basis for precipitated withdrawal diarrhea in morphine-dependent rats.
    The Journal of pharmacology and experimental therapeutics, 1984, Volume: 228, Issue:2

    Topics: Animals; Atropine; Biological Transport; Diarrhea; Gastrointestinal Motility; Hexamethonium Compounds; Humans; Intestinal Absorption; Male; Morphine; Morphine Dependence; Naltrexone; Quaternary Ammonium Compounds; Rats; Rats, Inbred Lew; Substance Withdrawal Syndrome; Water-Electrolyte Balance

1984
Increased brain size and cellular content in infant rats treated with an opiate antagonist.
    Science (New York, N.Y.), 1983, Sep-16, Volume: 221, Issue:4616

    Topics: Animals; Animals, Newborn; Body Weight; Brain; Cerebellum; Morphine; Naloxone; Naltrexone; Neuroglia; Organ Size; Rats; Rats, Inbred Strains; Somatosensory Cortex

1983
Role of endorphins in endotoxin-induced hyperglycaemia in mice.
    Neuropharmacology, 1983, Volume: 22, Issue:9

    Topics: Animals; Blood Glucose; Drug Tolerance; Endorphins; Endotoxins; Hyperglycemia; Male; Mice; Mice, Inbred C3H; Morphine; Naloxone; Naltrexone

1983
Opiate antagonists, morphine and spatial memory in rats.
    Pharmacology, biochemistry, and behavior, 1983, Volume: 19, Issue:3

    Topics: Animals; Dose-Response Relationship, Drug; Endorphins; Male; Memory; Morphine; Naloxone; Naltrexone; Rats; Retention, Psychology

1983
Morphine antagonizes pentobarbital-induced anesthesia.
    Neuropharmacology, 1983, Volume: 22, Issue:10

    Topics: Anesthesia; Animals; Atropine; Behavior, Animal; Electroencephalography; Male; Morphine; Naloxone; Naltrexone; Pentobarbital; Rabbits; Seizures

1983
Inhibition of morphine-induced analgesia and locomotor activity in strains of mice: a comparison of long-acting opiate antagonists.
    Pharmacology, biochemistry, and behavior, 1983, Volume: 19, Issue:6

    Topics: Animals; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Morphine; Motor Activity; Naloxone; Naltrexone; Pain; Species Specificity

1983
Proanaphylactic action of morphine is mediated through a central cholinergic mechanism.
    European journal of pharmacology, 1983, Nov-11, Volume: 95, Issue:1-2

    Topics: Anaphylaxis; Animals; Atropine Derivatives; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Parasympathetic Nervous System

1983
Prolonged excretion of morphine in rats during protracted abstinence: lack of effect of naltrexone.
    The Journal of pharmacology and experimental therapeutics, 1983, Volume: 224, Issue:2

    Topics: Animals; Body Weight; Gas Chromatography-Mass Spectrometry; Humans; Male; Morphine; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome

1983
A preliminary description of acute physical dependence on morphine in the vervet monkey.
    Pharmacology, biochemistry, and behavior, 1983, Volume: 18, Issue:2

    Topics: Animals; Behavior, Animal; Catheterization; Chlorocebus aethiops; Humans; Male; Morphine; Morphine Dependence; Naloxone; Naltrexone; Substance Withdrawal Syndrome

1983
Reversal of morphine-induced catalepsy in the rat by narcotic antagonists and their quaternary derivatives.
    Neuropharmacology, 1983, Volume: 22, Issue:3

    Topics: Animals; Catalepsy; Humans; Injections, Intraventricular; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains

1983
Spinal antagonism of tolerance and dependence induced by systemically administered morphine.
    European journal of pharmacology, 1983, Oct-14, Volume: 94, Issue:1-2

    Topics: Animals; Drug Tolerance; Humans; Male; Morphine; Morphine Dependence; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Reaction Time; Spinal Cord

1983
Opioid peptides mediate the suppressive effect of stress on natural killer cell cytotoxicity.
    Science (New York, N.Y.), 1984, Jan-13, Volume: 223, Issue:4632

    Topics: Animals; Cytotoxicity, Immunologic; Dose-Response Relationship, Drug; Endorphins; Female; Killer Cells, Natural; Morphine; Naltrexone; Rats; Rats, Inbred F344; Stress, Physiological

1984
Naloxone improves, and morphine exacerbates, experimental shock induced by release of endogenous histamine by compound 48/80.
    Brain research, 1984, Apr-09, Volume: 297, Issue:1

    Topics: Animals; Central Nervous System; Endorphins; Histamine; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Naltrexone; p-Methoxy-N-methylphenethylamine; Shock

1984
Electrochemical chromatographic determinations of morphine antagonists in biological fluids, with applications.
    Journal of pharmaceutical sciences, 1984, Volume: 73, Issue:5

    Topics: Animals; Chromatography, High Pressure Liquid; Dogs; Electrochemistry; Erythrocytes; Humans; In Vitro Techniques; Morphine; Naloxone; Naltrexone; Protein Binding; Ultracentrifugation

1984
Phencyclidine-like discriminative stimulus properties of psychotomimetic opioids.
    Annals of the New York Academy of Sciences, 1982, Volume: 398

    Topics: Animals; Columbidae; Cyclazocine; Discrimination, Psychological; Ethylketocyclazocine; Generalization, Psychological; Generalization, Stimulus; Morphine; Naltrexone; Phencyclidine; Rats; Saimiri

1982
Stimulus effects of morphine in the monkey: quantitative analysis of antagonism.
    Pharmacology, biochemistry, and behavior, 1980, Volume: 12, Issue:4

    Topics: Animals; Discrimination Learning; Dose-Response Relationship, Drug; Drug Interactions; Female; Haplorhini; Male; Morphine; Naltrexone; Prejudice; Saimiri

1980
Development of drug delivery systems for use in treatment of narcotic addiction.
    NIDA research monograph, 1981, Volume: 28

    Topics: Animals; Delayed-Action Preparations; Drug Compounding; Drug Implants; Haplorhini; Humans; Morphine; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; United States

1981
An improved long-acting delivery system for narcotic antagonists.
    NIDA research monograph, 1981, Volume: 28

    Topics: Animals; Drug Implants; Haplorhini; Morphine; Naltrexone; Narcotic Antagonists

1981
Historical perspective on the chemistry and development of naltrexone.
    NIDA research monograph, 1981, Volume: 28

    Topics: Animals; Benzomorphans; Heroin Dependence; History, 20th Century; Humans; Morphine; Naloxone; Naltrexone; Narcotic Antagonists

1981
Pharmacological evaluation of narcotic antagonist delivery systems in rhesus monkeys.
    NIDA research monograph, 1981, Volume: 28

    Topics: Animals; Drug Evaluation, Preclinical; Drug Implants; Infusions, Parenteral; Macaca mulatta; Morphine; Naltrexone; Narcotic Antagonists; Self Administration; Time Factors

1981
Threshold differences for naloxone and naltrexone in the hypothalamus and midbrain using fixed ratio brain self-stimulation in rats.
    Psychopharmacology, 1981, Volume: 74, Issue:1

    Topics: Animals; Brain; Dose-Response Relationship, Drug; Electrodes, Implanted; Hypothalamus; Male; Mesencephalon; Morphine; Naloxone; Naltrexone; Rats; Reinforcement Schedule; Self Stimulation

1981
Effects of selected opioid agonists and antagonists on DMT- and LSD-25-induced disruption of food-rewarded bar pressing behavior in the rat.
    Psychopharmacology, 1981, Volume: 75, Issue:3

    Topics: Animals; Conditioning, Operant; Drug Interactions; Drug Synergism; Lysergic Acid Diethylamide; Male; Methadone; Morphine; N,N-Dimethyltryptamine; Naloxone; Naltrexone; Narcotics; Rats; Reinforcement, Psychology; Tryptamines

1981
Cardiovascular effects of naloxone, naltrexone and morphine in the squirrel monkey.
    Life sciences, 1983, Jan-24, Volume: 32, Issue:4

    Topics: Animals; Blood Pressure; Dose-Response Relationship, Drug; Heart Rate; Male; Morphine; Naloxone; Naltrexone; Saimiri

1983
Attenuation of alcohol drinking in tetrahydroisoquinoline-treated rats by morphine and naltrexone.
    Pharmacology, biochemistry, and behavior, 1983, Volume: 18, Issue:2

    Topics: Alcohol Drinking; Animals; Body Weight; Drinking Behavior; Feeding Behavior; Isoquinolines; Male; Morphine; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Tetrahydroisoquinolines

1983
Effects of opiate agonists and antagonists on fluid intake and saccharin choice in the rat.
    Neuropharmacology, 1983, Volume: 22, Issue:3

    Topics: Animals; Choice Behavior; Drinking Behavior; Enkephalins; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Saccharin

1983
Involvement of central muscarinic cholinergic mechanisms in opioid stress analgesia.
    Brain research, 1983, Jul-04, Volume: 270, Issue:2

    Topics: Animals; Electroshock; Endorphins; Male; Morphine; Naltrexone; Oxotremorine; Pain; Rats; Rats, Inbred Strains; Receptors, Cholinergic; Receptors, Muscarinic; Scopolamine; Stress, Physiological

1983
Acquisition of brightness discrimination in the rat is impaired by opiates with psychotomimetic properties.
    Pharmacology, biochemistry, and behavior, 1983, Volume: 18, Issue:6

    Topics: Animals; Avoidance Learning; Cyclazocine; Discrimination Learning; Male; Morphine; Nalorphine; Naltrexone; Narcotics; Pentazocine; Phenazocine; Photic Stimulation; Psychotropic Drugs; Rats; Rats, Inbred F344

1983
Narcotic discrimination in pigeons.
    The Journal of pharmacology and experimental therapeutics, 1980, Volume: 214, Issue:1

    Topics: Animals; Clonidine; Codeine; Columbidae; Cyclazocine; Discrimination Learning; Dose-Response Relationship, Drug; Ethylketocyclazocine; Ketamine; Meperidine; Morphine; Nalorphine; Naltrexone; Narcotics; Pentazocine; Pentobarbital; Species Specificity

1980
Classification of narcotics on the basis of their reinforcing, discriminative, and antagonist effects in rhesus monkeys.
    Federation proceedings, 1982, Volume: 41, Issue:2

    Topics: Animals; Behavior, Animal; Conditioning, Operant; Cyclazocine; Discrimination, Psychological; Ethylketocyclazocine; Humans; Macaca; Macaca mulatta; Morphine; Naloxone; Naltrexone; Narcotics; Opioid-Related Disorders; Reinforcement, Psychology; Self Administration

1982
Opiate antagonists stimulate ruminal motility of conscious goats.
    European journal of pharmacology, 1982, Jan-08, Volume: 77, Issue:1

    Topics: Animals; Female; Goats; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists; Rumen

1982
Opiates and thermoregulation in mice. II. Effects of opiate antagonists.
    The Journal of pharmacology and experimental therapeutics, 1982, Volume: 220, Issue:3

    Topics: Animals; Body Temperature Regulation; Dose-Response Relationship, Drug; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Time Factors

1982
Opiate modification of amygdaloid-kindled seizures in rats.
    Pharmacology, biochemistry, and behavior, 1982, Volume: 16, Issue:5

    Topics: Amygdala; Animals; Electroencephalography; Kindling, Neurologic; Male; Morphine; Naloxone; Naltrexone; Narcotics; Rats; Rats, Inbred Strains

1982
Adrenal medullary enkephalin-like peptides may mediate opioid stress analgesia.
    Science (New York, N.Y.), 1982, Aug-06, Volume: 217, Issue:4559

    Topics: Adrenal Medulla; Analgesia; Animals; Electroshock; Endorphins; Enkephalins; Male; Morphine; Naltrexone; Rats; Reserpine; Sodium Chloride; Stress, Physiological; Time Factors

1982
Quaternary narcotic antagonists' relative ability to prevent antinociception and gastrointestinal transit inhibition in morphine-treated rats as an index of peripheral selectivity.
    Life sciences, 1982, May-31, Volume: 30, Issue:22

    Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Gastrointestinal Motility; Male; Morphine; Nalorphine; Naloxone; Naltrexone; Pain; Rats; Structure-Activity Relationship

1982
Effects of yohimbine and naltrexone in counteraction of the morphine Straub tail and the amphetamine-potentiated morphine Straub tail in mice.
    Life sciences, 1982, Jun-14, Volume: 30, Issue:24

    Topics: Amphetamine; Animals; Male; Mice; Morphine; Naloxone; Naltrexone; Phentolamine; Tail; Yohimbine

1982
Development of tolerance to the effects of morphine on luteinizing hormone secretion as a function of castration in the male rat.
    The Journal of pharmacology and experimental therapeutics, 1982, Volume: 223, Issue:3

    Topics: Analgesics; Animals; Brain; Castration; Dose-Response Relationship, Drug; Drug Tolerance; Luteinizing Hormone; Male; Morphine; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Testosterone

1982
Effects of opiate antagonists and of morphine on chlordiazepoxide-induced hyperdipsia in the water-deprived rat.
    Neuropharmacology, 1982, Volume: 21, Issue:10

    Topics: Analysis of Variance; Animals; Chlordiazepoxide; Drinking; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Thirst; Water Deprivation

1982
Palatability-induced drinking after administration of morphine, naltrexone and diazepam in the non-deprived rat.
    Substance and alcohol actions/misuse, 1982, Volume: 3, Issue:5

    Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Drinking; Male; Morphine; Muridae; Naloxone; Naltrexone; Taste

1982
Naltrexone effects on morphine and food self-administration in morphine-dependent rhesus monkeys.
    The Journal of pharmacology and experimental therapeutics, 1981, Volume: 218, Issue:2

    Topics: Animals; Conditioning, Operant; Food; Humans; Macaca mulatta; Male; Morphine; Morphine Dependence; Naloxone; Naltrexone; Self Administration; Substance Withdrawal Syndrome

1981
Antagonism of gut, but not central effects of morphine with quaternary narcotic antagonists.
    European journal of pharmacology, 1982, Mar-12, Volume: 78, Issue:3

    Topics: Animals; Central Nervous System; Diarrhea; Digestive System; Dogs; Female; Humans; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Rats; Rats, Inbred Strains; Species Specificity; Substance Withdrawal Syndrome

1982
Acute and chronic effects of naltrexone and naloxone on schedule-controlled behavior of squirrel monkeys and pigeons.
    The Journal of pharmacology and experimental therapeutics, 1981, Volume: 216, Issue:3

    Topics: Animals; Behavior, Animal; Columbidae; Conditioning, Psychological; Dose-Response Relationship, Drug; Food; Male; Morphine; Naloxone; Naltrexone; Saimiri; Time Factors

1981
Disposition of morphine in rat brain: relationship to biological activity.
    The Journal of pharmacology and experimental therapeutics, 1981, Volume: 217, Issue:1

    Topics: Animals; Brain; Chromatography, Gas; Male; Morphine; Naltrexone; Pain; Radioimmunoassay; Rats

1981
Three-choice drug discrimination in the rat: morphine, cyclazocine and saline.
    The Journal of pharmacology and experimental therapeutics, 1981, Volume: 217, Issue:2

    Topics: Animals; Cyclazocine; Dextroamphetamine; Discrimination Learning; Discrimination, Psychological; Generalization, Stimulus; Male; Morphine; Naltrexone; Pentazocine; Rats; Secobarbital; Sodium Chloride

1981
Suppression of drinking by naloxone in rats homo- and heterozygous for diabetes insipidus.
    Pharmacology, biochemistry, and behavior, 1981, Volume: 15, Issue:1

    Topics: Animals; Diabetes Insipidus; Drinking Behavior; Heterozygote; Homozygote; Male; Morphine; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Time Factors

1981
Naltrexone and the tail flick reflex.
    Pharmacology, biochemistry, and behavior, 1981, Volume: 15, Issue:5

    Topics: Analgesics; Animals; Drug Interactions; Drug Tolerance; Male; Morphine; Naloxone; Naltrexone; Nociceptors; Rats; Rats, Inbred Strains; Reflex

1981
Effect of morphine on rectal temperature after acute and chronic treatment in the rat.
    Progress in neuro-psychopharmacology, 1981, Volume: 5, Issue:4

    Topics: Adrenalectomy; Animals; Body Temperature; Drug Tolerance; Male; Morphine; Naltrexone; Rats; Time Factors

1981
Discriminative stimulus effects of cyclazocine in the rat.
    The Journal of pharmacology and experimental therapeutics, 1980, Volume: 212, Issue:3

    Topics: Animals; Cyclazocine; Dose-Response Relationship, Drug; Generalization, Stimulus; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Prejudice; Psychotropic Drugs; Rats; Stimulation, Chemical; Time Factors

1980
Self-administration of D-Ala2-Met-enkephalinamide at hypothalamic self-stimulation sites.
    Brain research, 1980, Jul-21, Volume: 194, Issue:1

    Topics: Animals; Dextrorphan; Dose-Response Relationship, Drug; Electric Stimulation; Endorphins; Enkephalins; Hypothalamus; Levallorphan; Levorphanol; Male; Morphine; Naloxone; Naltrexone; Rats; Self Stimulation

1980
Alterations of evoked potentials link research in attention dysfunction to peptide response symptoms of schizophrenia.
    Advances in biochemical psychopharmacology, 1980, Volume: 22

    Topics: Acoustic Stimulation; Attention; Endorphins; Evoked Potentials; Humans; Morphine; Naltrexone; Pain; Peptides; Schizophrenia; Schizophrenic Psychology

1980
Pro- and anticonvulsant action of morphine in rats.
    Pharmacology, biochemistry, and behavior, 1980, Volume: 13, Issue:3

    Topics: Animals; Anticonvulsants; Convulsants; Male; Morphine; Motor Activity; Naltrexone; Rats; Time Factors

1980
Antinociceptive comparison of quipazine and morphine.
    Communications in psychopharmacology, 1980, Volume: 4, Issue:2

    Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Quinolines; Quipazine; Reaction Time

1980
Stereoselectivity of the stimulus effects of morphine and cyclazocine in the squirrel monkey.
    The Journal of pharmacology and experimental therapeutics, 1980, Volume: 215, Issue:2

    Topics: Animals; Avoidance Learning; Behavior, Animal; Cyclazocine; Dose-Response Relationship, Drug; Generalization, Psychological; Morphine; Naltrexone; Prejudice; Saimiri; Stereoisomerism

1980
Orally administered opioid antagonists reverse both mu and kappa opioid agonist delay of gastrointestinal transit in the guinea pig.
    Life sciences, 1995, Volume: 56, Issue:14

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Gastrointestinal Transit; Guinea Pigs; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid, kappa; Receptors, Opioid, mu

1995
Involvement of the dorsal raphe but not median raphe nucleus in morphine-induced increases in serotonin release in the rat forebrain.
    Neuroscience, 1995, Volume: 68, Issue:2

    Topics: Animals; Behavior, Animal; Body Temperature; Circadian Rhythm; Extracellular Space; Histocytochemistry; Male; Microdialysis; Morphine; Naltrexone; Narcotic Antagonists; Prosencephalon; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Receptor Agonists

1995
Differential modulation of alpha 2-adrenergic and mu-opioid spinal antinociception by neuropeptide FF.
    Peptides, 1995, Volume: 16, Issue:5

    Topics: Adrenergic alpha-Agonists; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Synergism; Imidazoles; Male; Medetomidine; Morphine; Naltrexone; Narcotic Antagonists; Neuropeptides; Oligopeptides; Pain; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Opioid, mu; Spinal Cord; Time Factors

1995
Ultra-low concentrations of naloxone selectively antagonize excitatory effects of morphine on sensory neurons, thereby increasing its antinociceptive potency and attenuating tolerance/dependence during chronic cotreatment.
    Proceedings of the National Academy of Sciences of the United States of America, 1995, Nov-07, Volume: 92, Issue:23

    Topics: Analgesia; Analgesics, Opioid; Animals; Behavior, Animal; Culture Techniques; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Electrophysiology; Ganglia, Spinal; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Neurons, Afferent; Pain Measurement; Substance Withdrawal Syndrome; Substance-Related Disorders

1995
Cocaine self-administration and naltrindole, a delta-selective opioid antagonist.
    Neuroreport, 1995, Jul-10, Volume: 6, Issue:10

    Topics: Animals; Cocaine; Conditioning, Operant; Drug Implants; Female; Male; Morphine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; Receptors, Opioid, delta; Self Administration

1995
Effects of naltrexone on morphine-induced tolerance and physical dependence and changes in cellular immune function in mice.
    Brain research, 1995, Aug-28, Volume: 690, Issue:1

    Topics: Animals; B-Lymphocytes; Body Weight; Cell Division; Drug Implants; Drug Tolerance; Female; Immunity, Cellular; Killer Cells, Natural; Mice; Morphine; Morphine Dependence; Naltrexone; Substance Withdrawal Syndrome; T-Lymphocytes

1995
The formalin-induced expression of tachykinin peptide and neurokinin receptor messenger RNAs in rat sensory ganglia and spinal cord is modulated by opiate preadministration.
    Neuroscience, 1995, Volume: 64, Issue:3

    Topics: Animals; Formaldehyde; Ganglia, Spinal; Gene Expression Regulation; Male; Morphine; Naltrexone; Neurokinin B; Pain; Premedication; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-3; RNA, Messenger; Spinal Cord; Substance P; Time Factors

1995
Kappa opioid inhibition of morphine and cocaine self-administration in rats.
    Brain research, 1995, May-29, Volume: 681, Issue:1-2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Cocaine; Dose-Response Relationship, Drug; Extinction, Psychological; Female; Morphine; Naltrexone; Narcotics; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reinforcement, Psychology; Self Administration

1995
Attenuation of tolerance to, and physical dependence on, morphine in the rat by inhibition of nitric oxide synthase.
    General pharmacology, 1995, Volume: 26, Issue:5

    Topics: Animals; Arginine; Drug Implants; Drug Tolerance; Enzyme Inhibitors; Male; Morphine; Morphine Dependence; Naltrexone; Nitric Oxide Synthase; omega-N-Methylarginine; Pain Measurement; Rats; Rats, Sprague-Dawley

1995
CCB, a novel specific kappa opioid agonist, which discriminates between opioid and sigma 1 recognition sites.
    Life sciences, 1995, Volume: 57, Issue:16

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzomorphans; Binding, Competitive; Male; Mice; Morphine; Naltrexone; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa

1995
Morphine and naltrexone modulate D2 but not D1 receptor induced motor behavior in MPTP-lesioned monkeys.
    Psychopharmacology, 1995, Volume: 118, Issue:4

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Behavior, Animal; Functional Laterality; Macaca mulatta; Male; Morphine; Naltrexone; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, sigma

1995
CNS levels of mu opioid receptor (MOR-1) mRNA during chronic treatment with morphine or naltrexone.
    Brain research bulletin, 1995, Volume: 38, Issue:2

    Topics: Animals; Central Nervous System; Drug Administration Schedule; Drug Tolerance; Male; Morphine; Naltrexone; Nucleic Acid Hybridization; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; RNA, Messenger; Sensitivity and Specificity; Time Factors; Up-Regulation

1995
Effects of a highly selective nonpeptide delta opioid receptor agonist, TAN-67, on morphine-induced antinociception in mice.
    Life sciences, 1995, Volume: 57, Issue:2

    Topics: Analgesics; Animals; Drug Interactions; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Subcutaneous; Male; Mice; Mice, Inbred Strains; Morphine; Naltrexone; Nociceptors; Oligopeptides; Quinolines; Receptors, Opioid, delta

1995
NMDA antagonists and clonidine block c-fos expression during morphine withdrawal.
    Synapse (New York, N.Y.), 1995, Volume: 20, Issue:1

    Topics: Animals; Clonidine; Dizocilpine Maleate; Gene Expression; Genes, fos; In Vitro Techniques; Isoquinolines; Male; Morphine; Naltrexone; Neural Pathways; Nucleic Acid Hybridization; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA Probes; RNA, Messenger; Substance Withdrawal Syndrome

1995
mu- and delta-opioid receptor-mediated contractile effects on rat aortic vascular smooth muscle.
    European journal of pharmacology, 1995, Apr-13, Volume: 277, Issue:1

    Topics: Amino Acid Sequence; Analgesics; Analysis of Variance; Animals; Aorta; Benzomorphans; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Molecular Sequence Data; Morphine; Muscle Contraction; Muscle, Smooth, Vascular; Naltrexone; Norepinephrine; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu

1995
Modification of mu-opioid agonist-induced locomotor activity and development of morphine dependence by diabetes.
    The Journal of pharmacology and experimental therapeutics, 1995, Volume: 274, Issue:2

    Topics: Animals; Diabetes Mellitus, Experimental; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Mice; Mice, Inbred ICR; Morphine; Morphine Dependence; Motor Activity; Naloxone; Naltrexone; Receptors, Opioid, mu; Streptozocin

1995
Mouse strain differences in in vivo and in vitro immunosuppressive effects of opioids.
    Advances in experimental medicine and biology, 1995, Volume: 373

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Erythrocytes; Female; Immunosuppressive Agents; Mice; Mice, Inbred Strains; Morphine; Naloxone; Naltrexone; Opioid Peptides; Pyrrolidines; Species Specificity; Spleen

1995
Morphine-induced alterations of immune status: dose dependency, compartment specificity and antagonism by naltrexone.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 265, Issue:3

    Topics: Animals; Concanavalin A; Dose-Response Relationship, Drug; Immunocompetence; Interferons; Interleukin-2; Killer Cells, Natural; Lymph Nodes; Lymphocytes; Male; Morphine; Naltrexone; Rats; Rats, Inbred Lew; Spleen

1993
Antisense oligodeoxynucleotide to the CCKB receptor produces naltrindole- and [Leu5]enkephalin antiserum-sensitive enhancement of morphine antinociception.
    Neuroreport, 1994, Dec-20, Volume: 5, Issue:18

    Topics: Animals; Drug Synergism; Enkephalin, Leucine; Immune Sera; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Narcotic Antagonists; Nociceptors; Oligonucleotides, Antisense; Receptors, Cholecystokinin

1994
Involvement of kappa-opioid receptor mechanisms in the calcitonin-induced potentiation of opioid effects at the hypothalamus-pituitary-adrenocortical axis.
    European journal of pharmacology, 1994, Dec-12, Volume: 271, Issue:1

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Calcitonin; Corticosterone; Drug Synergism; Hypothalamo-Hypophyseal System; Male; Morphine; Naltrexone; Narcotics; Pituitary-Adrenal System; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu

1994
Peripheral kappa-opioid receptors mediate the antinociceptive effect of fedotozine (correction of fetodozine) on the duodenal pain reflex inrat.
    European journal of pharmacology, 1994, Dec-12, Volume: 271, Issue:1

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzyl Compounds; Blood Pressure; Dose-Response Relationship, Drug; Duodenum; Injections, Intravenous; Injections, Intraventricular; Male; Morphine; Naloxone; Naltrexone; Pain; Propylamines; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reflex

1994
Immunologic characterization of TAT72-transgenic mice: effects of morphine on cell-mediated immunity.
    International journal of immunopharmacology, 1994, Volume: 16, Issue:12

    Topics: Animals; Gene Products, tat; Immunity, Cellular; Immunosuppressive Agents; Interleukin-2; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Inbred DBA; Mice, Transgenic; Morphine; Naltrexone; Stereoisomerism; T-Lymphocytes, Cytotoxic

1994
The increase in morphine antinociceptive potency produced by carrageenan-induced hindpaw inflammation is blocked by naltrindole, a selective delta-opioid antagonist.
    Neuroscience letters, 1995, Jan-30, Volume: 184, Issue:3

    Topics: Animals; Carrageenan; Hindlimb; Inflammation; Male; Morphine; Naltrexone; Nociceptors; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta

1995
A selective CCKB receptor antagonist potentiates, mu-, but not delta-opioid receptor-mediated antinociception in the formalin test.
    European journal of pharmacology, 1995, Jan-24, Volume: 273, Issue:1-2

    Topics: Analgesics; Animals; Disulfides; Enkephalins; Formaldehyde; Indoles; Male; Meglumine; Mice; Morphine; Naloxone; Naltrexone; Pain Measurement; Phenylalanine; Receptors, Cholecystokinin; Receptors, Opioid, delta; Receptors, Opioid, mu

1995
Assessment of endogenous enkephalins efficacy in the hot plate test in mice: comparative study with morphine.
    Neuroscience letters, 1995, Feb-09, Volume: 185, Issue:2

    Topics: Animals; Dose-Response Relationship, Drug; Enkephalins; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Receptors, Opioid, mu

1995
Pretreatment with beta-funaltrexamine blocks morphine-mediated suppression of CTL activity in alloimmunized mice.
    Immunopharmacology, 1995, Volume: 29, Issue:2

    Topics: Animals; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Female; Immunization; In Vitro Techniques; Isoantigens; Killer Cells, Natural; Lymphocyte Activation; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Morphine; Naltrexone; Spleen; T-Lymphocytes, Cytotoxic

1995
Morphine inhibits the development of allogeneic immune responses in mouse lymph node.
    Immunopharmacology, 1995, Volume: 29, Issue:2

    Topics: Animals; Graft Survival; Immunity; Isoantigens; Lymph Nodes; Lymphocyte Culture Test, Mixed; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Morphine; Naltrexone; Spleen; T-Lymphocyte Subsets; Transplantation, Homologous

1995
Effects of methylnaltrexone on morphine-induced inhibition of contraction in isolated guinea-pig ileum and human intestine.
    European journal of pharmacology, 1995, Mar-24, Volume: 276, Issue:1-2

    Topics: Adult; Aged; Animals; Gastrointestinal Motility; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Intestine, Small; Middle Aged; Morphine; Muscle Contraction; Naloxone; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds

1995
Effect of diabetes on the morphine-induced inhibition of gastrointestinal transit.
    Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 1995, Volume: 15, Issue:2

    Topics: Animals; Depression, Chemical; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Gastrointestinal Transit; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Naltrexone

1995
Effects of diabetes on the morphine-induced Straub tail reaction in mice.
    Neuroscience letters, 1994, Aug-29, Volume: 178, Issue:1

    Topics: Animals; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred ICR; Morphine; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu; Reference Values; Tail

1994
Morphine-induced straub tail response: mediated by central mu2-opioid receptor.
    European journal of pharmacology, 1994, Sep-22, Volume: 263, Issue:1-2

    Topics: Analgesia; Animals; Female; Injections, Intraventricular; Male; Mice; Morphine; Naloxone; Naltrexone; Receptors, Opioid, mu; Tail

1994
Differing mechanisms for proactive effects of intermittent and single shock on gastric ulceration.
    Physiology & behavior, 1994, Volume: 56, Issue:5

    Topics: Animals; Arousal; Dose-Response Relationship, Drug; Electroshock; Gastric Mucosa; Helplessness, Learned; Injections, Subcutaneous; Male; Morphine; Naltrexone; Pain Threshold; Proactive Inhibition; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Stomach Ulcer

1994
Pavlovian conditioning of morphine-induced alterations of immune status: evidence for opioid receptor involvement.
    Journal of neuroimmunology, 1994, Volume: 55, Issue:2

    Topics: Animals; Conditioning, Psychological; Interleukin-2; Killer Cells, Natural; Lipopolysaccharides; Lymphocyte Activation; Male; Morphine; Naltrexone; Rats; Rats, Inbred Lew; Receptors, Opioid

1994
Naloxone pretreatment blocks acute morphine-induced sensitization to naltrexone.
    Psychopharmacology, 1994, Volume: 114, Issue:2

    Topics: Animals; Conditioning, Operant; Dose-Response Relationship, Drug; Male; Morphine; Naloxone; Naltrexone; Rats; Rats, Sprague-Dawley; Reinforcement Schedule

1994
Repeated acquisition of behavioral chains in squirrel monkeys: comparisons of a mu, kappa and delta opioid agonist.
    The Journal of pharmacology and experimental therapeutics, 1995, Volume: 272, Issue:2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzamides; Conditioning, Operant; Dose-Response Relationship, Drug; Female; Morphine; Naltrexone; Piperazines; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Saimiri

1995
The effect of chronic treatment with naltrindole, a selective delta-opioid antagonist, on mu-opioid receptor-mediated antinociception in diabetic mice.
    Psychopharmacology, 1993, Volume: 113, Issue:2

    Topics: Analgesics; Animals; Diabetes Mellitus, Experimental; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intraventricular; Injections, Subcutaneous; Male; Mice; Mice, Inbred ICR; Monocytes; Morphine; Naltrexone; Narcotic Antagonists; Pain Measurement; Receptors, Opioid, delta; Receptors, Opioid, mu; Spleen

1993
Ultrasounds emitted by female rats during agonistic interactions: effects of morphine and naltrexone.
    Psychopharmacology, 1994, Volume: 114, Issue:3

    Topics: Agonistic Behavior; Animals; Dose-Response Relationship, Drug; Estrus; Female; Morphine; Naltrexone; Pain Measurement; Rats; Vocalization, Animal

1994
Blockade of delta-opioid receptors prevents morphine-induced place preference in mice.
    Japanese journal of pharmacology, 1994, Volume: 66, Issue:1

    Topics: Analgesics; Animals; Benzylidene Compounds; Conditioning, Operant; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Mice, Inbred Strains; Morphine; Naltrexone; Narcotic Antagonists; Oligopeptides; Receptors, Opioid, delta; Receptors, Opioid, mu

1994
Antagonism of the morphine-induced Straub tail reaction by kappa-opioid receptor activation in mice.
    Psychopharmacology, 1993, Volume: 110, Issue:1-2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Dose-Response Relationship, Drug; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Morphine; Naltrexone; Narcotic Antagonists; Pain Measurement; Pyrrolidines; Receptors, Opioid, kappa

1993
Involvement of delta-opioid receptors in the effects of morphine on locomotor activity and the mesolimbic dopaminergic system in mice.
    Psychopharmacology, 1993, Volume: 111, Issue:4

    Topics: 3,4-Dihydroxyphenylacetic Acid; Analgesics; Animals; Dopamine; Homovanillic Acid; Limbic System; Male; Mice; Mice, Inbred Strains; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Postural Balance; Reaction Time; Receptors, Opioid, delta

1993
Mechanisms of morphine-induced immunosuppression: effect of acute morphine administration on lymphocyte trafficking.
    The Journal of pharmacology and experimental therapeutics, 1995, Volume: 272, Issue:3

    Topics: Adrenalectomy; Animals; Cell Movement; Fentanyl; Immunosuppression Therapy; Leukocyte Count; Lymphocyte Activation; Lymphocyte Count; Lymphocytes; Male; Morphine; Naltrexone; Rats; Rats, Sprague-Dawley; T-Lymphocyte Subsets

1995
Naltrindole, an opioid delta antagonist, blocks the enhancement of morphine-antinociception induced by a CCKB antagonist in the rat.
    Neuroscience letters, 1994, Nov-07, Volume: 181, Issue:1-2

    Topics: Animals; Benzodiazepinones; Injections, Spinal; Injections, Subcutaneous; Male; Morphine; Naltrexone; Narcotic Antagonists; Nociceptors; Pain Measurement; Phenylurea Compounds; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Receptors, Opioid, delta

1994
Inhibiting a spinal dynorphin A component enhances intrathecal morphine antinociception in mice.
    Anesthesia and analgesia, 1993, Volume: 77, Issue:6

    Topics: Analgesics; Animals; Cerebral Ventricles; Dynorphins; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Spine

1993
Dynorphin A(1-17) mediates midazolam antagonism of morphine antinociception in mice.
    Pharmacology, biochemistry, and behavior, 1993, Volume: 46, Issue:2

    Topics: Analgesics; Animals; Clonidine; Dose-Response Relationship, Drug; Dynorphins; GABA Antagonists; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Midazolam; Morphine; Naloxone; Naltrexone; Pain Measurement; Reaction Time; Spinal Cord

1993
Blockade of morphine reward through the activation of kappa-opioid receptors in mice.
    Neuropharmacology, 1993, Volume: 32, Issue:12

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; 3,4-Dihydroxyphenylacetic Acid; Analgesics; Animals; Apomorphine; Conditioning, Operant; Dopamine; Dynorphins; Homovanillic Acid; Injections, Subcutaneous; Limbic System; Male; Mice; Mice, Inbred Strains; Morphine; Motivation; Naltrexone; Peptide Fragments; Prosencephalon; Pyrrolidines; Receptors, Opioid, kappa; Reward

1993
Effects of mu, delta and kappa opioid antagonists on the depression of a C-fiber reflex by intrathecal morphine and DAGO in the rat.
    The Journal of pharmacology and experimental therapeutics, 1994, Volume: 269, Issue:3

    Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Spinal; Morphine; Naltrexone; Narcotic Antagonists; Nerve Fibers; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reflex; Somatostatin

1994
Pharmacological characterization of dynorphin A (1-17)-induced effects on spinal cord-evoked potentials.
    The Journal of pharmacology and experimental therapeutics, 1994, Volume: 270, Issue:2

    Topics: Animals; Drug Interactions; Dynorphins; Evoked Potentials; Ganglia, Spinal; Male; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Spinal Cord

1994
Receptor-mediated regulation of neuropeptide gene expression in astrocytes.
    Glia, 1994, Volume: 11, Issue:2

    Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Astrocytes; Benzomorphans; Brain; Enkephalin, Methionine; Etorphine; Gene Expression Regulation; Morphine; Naltrexone; Nerve Tissue Proteins; Neuropeptides; Organ Specificity; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; Receptors, Opioid

1994
Opioids inhibit endothelin-mediated DNA synthesis, phosphoinositide turnover, and Ca2+ mobilization in rat C6 glioma cells.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1994, Volume: 14, Issue:10

    Topics: Animals; Antibodies, Anti-Idiotypic; beta-Endorphin; Calcium; Desipramine; DNA, Neoplasm; Dose-Response Relationship, Drug; Endothelins; Glioma; Morphine; Naltrexone; Phosphatidylinositols; Rats; Receptors, Opioid; Thymidine; Tumor Cells, Cultured

1994
A mechanism of action for morphine-induced immunosuppression: corticosterone mediates morphine-induced suppression of natural killer cell activity.
    The Journal of pharmacology and experimental therapeutics, 1994, Volume: 270, Issue:3

    Topics: Animals; Cells, Cultured; Corticosterone; Female; Immunosuppressive Agents; Killer Cells, Natural; Mice; Morphine; Naloxone; Naltrexone; Receptors, Opioid; Spleen

1994
The involvement of opioid delta receptor in restraint-induced antinociception in mice.
    Methods and findings in experimental and clinical pharmacology, 1994, Volume: 16, Issue:5

    Topics: Animals; Female; Male; Mice; Mice, Inbred CFTR; Morphine; Naltrexone; Narcotic Antagonists; Nociceptors; Pain Measurement; Receptors, Opioid, delta; Receptors, Opioid, mu; Restraint, Physical; Sex Factors

1994
Participation of opioid receptor types on post-tetanic twitch inhibition in isolated guinea-pig ileal longitudinal muscle.
    Neuropharmacology, 1994, Volume: 33, Issue:5

    Topics: Amino Acid Sequence; Animals; Dynorphins; Electric Stimulation; Enkephalin, Leucine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Molecular Sequence Data; Morphine; Muscle Contraction; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Narcotics; Peptide Fragments; Receptors, Opioid

1994
In vivo apparent pA2 analysis for naltrexone antagonism of discriminative stimulus and analgesic effects of opiate agonists in rats.
    The Journal of pharmacology and experimental therapeutics, 1994, Volume: 271, Issue:2

    Topics: Analgesia; Animals; Benzomorphans; Buprenorphine; Discrimination, Psychological; Etorphine; Fentanyl; Male; Morphine; Nalbuphine; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu

1994
Morphine reduces the release of met-enkephalin-like material from the rat spinal cord in vivo by acting at delta opioid receptors.
    Neuropeptides, 1994, Volume: 27, Issue:1

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Injections, Spinal; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pyrrolidines; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Spinal Cord

1994
The effect of chronic naltrexone pretreatment on associative vs. non-associative morphine tolerance.
    Drug and alcohol dependence, 1994, Volume: 36, Issue:1

    Topics: Animals; Association Learning; Conditioning, Classical; Male; Morphine; Naltrexone; Pain Threshold; Premedication; Rats; Rats, Sprague-Dawley; Reaction Time

1994
Antinociceptive and response rate-altering effects of kappa opioid agonists, spiradoline, enadoline and U69,593, alone and in combination with opioid antagonists in squirrel monkeys.
    The Journal of pharmacology and experimental therapeutics, 1994, Volume: 271, Issue:3

    Topics: Analgesics; Animals; Azocines; Benzeneacetamides; Benzofurans; Dose-Response Relationship, Drug; Male; Morphine; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid, kappa; Saimiri

1994
Morphine-induced decreases in in vivo antibody responses.
    Brain, behavior, and immunity, 1994, Volume: 8, Issue:1

    Topics: Animals; Antibody Formation; Hydrocortisone; Immunologic Deficiency Syndromes; Male; Morphine; Naltrexone; Neuroimmunomodulation; Rats; Rats, Inbred F344; Rats, Sprague-Dawley

1994
Streptozotocin-induced diabetes selectively reduces antinociception mediated by mu 1-opioid receptors, but not that mediated by mu 2-opioid receptors.
    Neuroscience letters, 1994, Jan-03, Volume: 165, Issue:1-2

    Topics: Analgesics; Animals; Diabetes Mellitus, Experimental; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Receptors, Opioid, mu; Spinal Cord

1994
Opioid receptor agonist potencies of morphine and morphine-6-glucuronide in the guinea-pig ileum.
    European journal of pharmacology, 1994, Apr-01, Volume: 255, Issue:1-3

    Topics: Amino Acid Sequence; Animals; Electric Stimulation; Guinea Pigs; Ileum; In Vitro Techniques; Male; Molecular Sequence Data; Morphine; Morphine Derivatives; Muscle Contraction; Muscle, Smooth; Naltrexone; Peptide Fragments; Peptides; Receptors, Opioid; Receptors, Opioid, mu; Somatostatin

1994
Effects of naltrexone pellet implantation on morphine tolerance and physical dependence in the rat.
    General pharmacology, 1994, Volume: 25, Issue:1

    Topics: Analgesia; Animals; Body Temperature; Dose-Response Relationship, Drug; Drug Implants; Drug Interactions; Drug Tolerance; Male; Morphine; Naltrexone; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors; Weight Loss

1994
Effect of morphine tolerance and abstinence on the binding of [3H]naltrexone to discrete brain regions and spinal cord of the rat.
    General pharmacology, 1994, Volume: 25, Issue:2

    Topics: Analgesics; Animals; Brain; Drug Implants; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Membranes; Morphine; Morphine Dependence; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, mu; Spinal Cord; Substance Withdrawal Syndrome

1994
Lack of involvement of delta-1 opioid receptors in the development of physical dependence on morphine in mice.
    The Journal of pharmacology and experimental therapeutics, 1994, Volume: 270, Issue:1

    Topics: Affinity Labels; Animals; Diarrhea; Enkephalin, Leucine-2-Alanine; Injections, Intraventricular; Injections, Spinal; Isothiocyanates; Male; Mice; Morphine; Naloxone; Naltrexone; Receptors, Opioid, delta; Substance-Related Disorders

1994
Role of vagal afferents in the antinociception produced by morphine and U-50,488H in the colonic pain reflex in rats.
    European journal of pharmacology, 1994, May-12, Volume: 257, Issue:1-2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Blood Pressure; Colon; Injections, Intraventricular; Injections, Spinal; Male; Morphine; Naloxone; Naltrexone; Neurons, Afferent; Pain; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reflex; Vagotomy; Vagus Nerve

1994
The use of specific opioid agonists and antagonists to delineate the vagally mediated antinociceptive and cardiovascular effects of intravenous morphine.
    Brain research, 1993, Feb-19, Volume: 603, Issue:2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analysis of Variance; Animals; Blood Pressure; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Heart Rate; Hexamethonium; Hexamethonium Compounds; Indoles; Injections, Intravenous; Male; Morphinans; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pain; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reference Values; Time Factors; Vagotomy; Vagus Nerve

1993
Opioid antagonists: indirect antagonism of morphine analgesia by spinal dynorphin A.
    Pharmacology, biochemistry, and behavior, 1993, Volume: 45, Issue:2

    Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Dynorphins; Injections, Intraventricular; Injections, Spinal; Levallorphan; Male; Mice; Mice, Inbred ICR; Morphine; Nalbuphine; Naltrexone; Nociceptors; Spinal Cord

1993
Effects of naltrexone on the binding of [3H]D-Ala2, MePhe4, Gly-ol5-enkephalin to brain regions and spinal cord and pharmacological responses to morphine in the rat.
    General pharmacology, 1993, Volume: 24, Issue:6

    Topics: Analgesics; Animals; Body Temperature; Brain; Drug Implants; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Morphine; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Spinal Cord; Up-Regulation

1993
Hyperalgesic and analgesic actions of morphine, U50-488, naltrexone, and (-)-lobeline in the rat brainstem.
    Pharmacology, biochemistry, and behavior, 1994, Volume: 47, Issue:1

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Dose-Response Relationship, Drug; Female; Lobeline; Microinjections; Morphine; Naltrexone; Pain; Pain Measurement; Pyrrolidines; Rats; Rats, Sprague-Dawley; Tegmentum Mesencephali

1994
The nature of conditioned anti-analgesia: spinal cord opiate and anti-opiate neurochemistry.
    Brain research, 1994, Jan-21, Volume: 634, Issue:2

    Topics: Analgesia; Analgesics; Animals; Conditioning, Classical; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Immune Sera; Injections, Spinal; Male; Morphine; Naltrexone; Narcotic Antagonists; Oligopeptides; Proglumide; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Spinal Cord

1994
mu-Opioid receptors modulate noradrenaline release from the rat hippocampus as measured by brain microdialysis.
    Brain research, 1994, Feb-04, Volume: 636, Issue:1

    Topics: Analgesics; Animals; Benzeneacetamides; Chromatography, High Pressure Liquid; Desipramine; Electrochemistry; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Extracellular Space; GTP-Binding Proteins; Hippocampus; Male; Microdialysis; Morphine; Naltrexone; Nerve Endings; Norepinephrine; Potassium; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, mu; Virulence Factors, Bordetella

1994
Serum prolactin response to ether stress in diabetic rats: opiate system contribution.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1994, Volume: 205, Issue:3

    Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Ether; Male; Morphine; Naltrexone; Narcotic Antagonists; Prolactin; Rats; Rats, Wistar; Receptors, Opioid; Stress, Physiological

1994
Opioids and corticosteroids involvement in the regulation of the neocortical spindling episodes in DBA/2J mice.
    Annali dell'Istituto superiore di sanita, 1993, Volume: 29, Issue:3

    Topics: Adrenal Cortex; Animals; Cerebral Cortex; Corticosterone; Cycloheximide; Dexamethasone; Disease Models, Animal; Disease Susceptibility; Electroencephalography; Epilepsy; Genetic Predisposition to Disease; Male; Mice; Mice, Inbred DBA; Mifepristone; Morphine; Naltrexone

1993
Area tempestas modulates the behavioural responses to nociceptive stimuli in rats.
    Annali dell'Istituto superiore di sanita, 1993, Volume: 29, Issue:3

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Anticonvulsants; Azocines; Bicuculline; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Escape Reaction; Foot; Hot Temperature; Male; Morphine; Naltrexone; Narcotic Antagonists; Olfactory Pathways; Pain; Phenazocine; Pressure; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid; Seizures; Tail

1993
Antagonistic effects of the selective, competitive N-methyl-D-aspartate (NMDA) receptor antagonist, NPC 12626, on kappa opiate-induced analgesia in male deer mice.
    Brain research, 1994, Feb-21, Volume: 637, Issue:1-2

    Topics: Amino Acids; Analgesics; Animals; Benzeneacetamides; Dizocilpine Maleate; Dose-Response Relationship, Drug; Male; Morphine; Naloxone; Naltrexone; Nociceptors; Pain Measurement; Peromyscus; Pyrrolidines; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa

1994
Naltrexone antagonizes the analgesic and immunosuppressive effects of morphine in mice.
    The Journal of pharmacology and experimental therapeutics, 1994, Volume: 269, Issue:2

    Topics: Animals; Dose-Response Relationship, Drug; Immunosuppressive Agents; Killer Cells, Natural; Male; Mice; Morphine; Naltrexone; Pain Measurement; Spleen; Tumor Cells, Cultured

1994
Amphetamine-induced modification of quinine palatability: analysis by the taste reactivity test.
    Pharmacology, biochemistry, and behavior, 1994, Volume: 47, Issue:3

    Topics: Animals; Dextroamphetamine; Drinking Behavior; Male; Morphine; Motor Activity; Naltrexone; Pimozide; Quinine; Rats; Rats, Sprague-Dawley; Sucrose; Taste

1994
Acute sensitization to opioid antagonists.
    Pharmacology, biochemistry, and behavior, 1994, Volume: 47, Issue:3

    Topics: Animals; Conditioning, Operant; Dose-Response Relationship, Drug; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Reinforcement Schedule; Stereoisomerism

1994
Antinociceptive effect of dihydroetorphine and its tolerance/dependence liability in mice.
    Biological & pharmaceutical bulletin, 1993, Volume: 16, Issue:8

    Topics: Analgesics; Animals; Body Weight; Drug Tolerance; Etorphine; Male; Mice; Mice, Inbred Strains; Morphine; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Substance-Related Disorders

1993
Restraint stress potentiates analgesia induced by 5'-N-ethylcarboxamidoadenosine: comparison with morphine.
    European journal of pharmacology, 1993, Aug-03, Volume: 239, Issue:1-3

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Analgesia; Animals; Caffeine; Dose-Response Relationship, Drug; Drug Interactions; Male; Morphine; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Restraint, Physical; Stress, Physiological

1993
Antinociceptive activity of intrathecal ketorolac is blocked by the kappa-opioid receptor antagonist, nor-binaltorphimine.
    European journal of pharmacology, 1993, Sep-21, Volume: 242, Issue:1

    Topics: Analgesics; Animals; Drug Interactions; Drug Tolerance; Injections, Spinal; Ketorolac; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Pain; Receptors, Opioid, kappa; Tolmetin

1993
Hepatic and splenic phagocytosis in female B6C3F1 mice implanted with morphine sulfate pellets.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 267, Issue:1

    Topics: Animals; Drug Tolerance; Female; Kupffer Cells; Liver; Macrophages; Mice; Mice, Inbred Strains; Mifepristone; Mononuclear Phagocyte System; Morphine; Naltrexone; Organ Size; Phagocytosis; Spleen

1993
Discriminative stimulus effects of BW373U86: a nonpeptide ligand with selectivity for delta opioid receptors.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 267, Issue:2

    Topics: Amino Acid Sequence; Analgesics; Animals; Benzamides; Benzomorphans; Columbidae; Discrimination Learning; Enkephalin, Leucine; Molecular Sequence Data; Morphine; Naltrexone; Narcotic Antagonists; Piperazines; Receptors, Opioid, delta; Receptors, Opioid, mu

1993
Possible contribution of a glutathione conjugate to the long-duration action of beta-funaltrexamine.
    Journal of medicinal chemistry, 1993, Nov-12, Volume: 36, Issue:23

    Topics: Analgesia; Animals; Enkephalin, Leucine-2-Alanine; Glutathione; Guinea Pigs; Kinetics; Male; Mice; Morphine; Muscles; Naltrexone; Receptors, Opioid, mu; Structure-Activity Relationship; Vas Deferens

1993
Medullary mu and delta opioid receptors modulate mesencephalic morphine analgesia in rats.
    Brain research, 1993, Oct-08, Volume: 624, Issue:1-2

    Topics: Analgesics; Animals; Male; Medulla Oblongata; Mesencephalon; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu

1993
Opioidergic manipulations affect intake of 3% NaCl in sodium-deficient rats.
    Pharmacology, biochemistry, and behavior, 1993, Volume: 46, Issue:2

    Topics: Animals; Body Weight; Drinking Behavior; Furosemide; Male; Morphine; Naltrexone; Narcotics; Rats; Rats, Sprague-Dawley; Sodium; Sodium Chloride, Dietary

1993
Opioid antagonist-induced receptor upregulation: effects of concurrent agonist administration.
    Brain research bulletin, 1994, Volume: 33, Issue:2

    Topics: Animals; Brain; Drug Combinations; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Fentanyl; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu; Up-Regulation

1994
A monoclonal anti-idiotypic antibody to opioid receptors labels desipramine-induced opioid binding sites on rat C6 glioma cells and attenuates thymidine incorporation into DNA.
    Glia, 1994, Volume: 10, Issue:1

    Topics: Animals; Antibodies, Monoclonal; Brain Neoplasms; Cell Division; Cell Membrane; Colorimetry; Densitometry; Desipramine; DNA, Neoplasm; Glioma; Immunohistochemistry; Morphine; Naltrexone; Pertussis Toxin; Rats; Receptors, Opioid; Thymidine; Tumor Cells, Cultured; Virulence Factors, Bordetella

1994
Naltrexone in vivo protects mu receptors from inactivation by beta-funaltrexamine, but not kappa receptors from inactivation by nor-binaltorphimine.
    Pharmacology, biochemistry, and behavior, 1993, Volume: 46, Issue:4

    Topics: Analgesics; Animals; Benzeneacetamides; Cisterna Magna; Dose-Response Relationship, Drug; Injections; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain Measurement; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu

1993
Opioid modulation of amphetamine-stimulated dopamine release and concentration in rat striatal slices.
    Pharmacology, biochemistry, and behavior, 1993, Volume: 46, Issue:4

    Topics: 3,4-Dihydroxyphenylacetic Acid; Amphetamine; Animals; Dihydroxyphenylalanine; Dopamine; Hydrazines; In Vitro Techniques; Male; Morphine; Naltrexone; Narcotics; Neostriatum; Rats; Rats, Sprague-Dawley

1993
Morphine treatment in vitro or in vivo decreases phagocytic functions of murine macrophages.
    Life sciences, 1993, Volume: 53, Issue:12

    Topics: Animals; Candida albicans; Depression, Chemical; Drug Interactions; Female; Macrophages; Mice; Mice, Inbred C3H; Morphine; Naltrexone; Peritoneal Cavity; Phagocytosis; Time Factors

1993
Prostaglandin E2-induced thermal hyperalgesia and its reversal by morphine in the warm-water tail-withdrawal procedure in rhesus monkeys.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 266, Issue:3

    Topics: Animals; Azocines; Data Interpretation, Statistical; Dinoprostone; Dose-Response Relationship, Drug; Female; Hot Temperature; Hyperalgesia; Macaca mulatta; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain Measurement; Sodium Chloride; Temperature

1993
Modification of morphine-induced locomotor activity by pertussis toxin: biochemical and behavioral studies in mice.
    Brain research, 1993, Aug-13, Volume: 619, Issue:1-2

    Topics: Analgesics; Analysis of Variance; Animals; Cerebral Ventricles; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intraventricular; Injections, Subcutaneous; Kinetics; Male; Mice; Mice, Inbred Strains; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Pertussis Toxin; Time Factors; Virulence Factors, Bordetella

1993
Electrophysiological actions of delta opioids in CA1 of the rat hippocampal slice are mediated by one delta receptor subtype.
    Brain research, 1993, Jan-22, Volume: 601, Issue:1-2

    Topics: Analgesics; Animals; Electric Stimulation; Electrophysiology; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Evoked Potentials; Hippocampus; In Vitro Techniques; Indoles; Ligands; Male; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Pyramidal Tracts; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu

1993
The kappa opioid agonist U-50,488H antagonizes respiratory effects of mu opioid receptor agonists in conscious rats.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 264, Issue:2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Morphine; Naltrexone; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Respiration

1993
Effects of opiates on neuronal development in the rat cerebral cortex.
    Brain research bulletin, 1993, Volume: 30, Issue:5-6

    Topics: Animals; Body Weight; Cerebral Cortex; Female; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Neurons; Pregnancy; Rats; Rats, Sprague-Dawley; Somatosensory Cortex

1993
Independent expression of two pharmacologically distinct supraspinal mu analgesic systems in genetically different mouse strains.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 265, Issue:1

    Topics: Analgesia; Animals; Brain Stem; Drug Administration Routes; Male; Mice; Morphine; Naloxone; Naltrexone; Receptors, Opioid, mu; Species Specificity; Spinal Cord

1993
Effects of the kappa-opioid agonist U50,488 on parturition in rats.
    British journal of pharmacology, 1993, Volume: 109, Issue:1

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Female; Infusions, Intravenous; Injections, Intravenous; Labor, Obstetric; Male; Morphine; Naloxone; Naltrexone; Oxytocin; Pregnancy; Pyrrolidines; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Opioid, kappa; Uterine Contraction

1993
Withdrawal contractures of guinea-pig isolated ileum after acute activation of kappa-opioid receptors.
    British journal of pharmacology, 1993, Volume: 109, Issue:1

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Clonidine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Nifedipine; Pyrrolidines; Receptors, Opioid, kappa; Substance Withdrawal Syndrome

1993
Chronic exposure to morphine and naltrexone induces changes in catecholaminergic neurotransmission in rat brain without altering mu-opioid receptor sensitivity.
    Life sciences, 1993, Volume: 52, Issue:21

    Topics: Adenylyl Cyclases; Animals; Binding Sites; Brain; Catecholamines; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Morphine; Naltrexone; Norepinephrine; Radioligand Assay; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Opioid, mu

1993
Opioid control of the release of calcitonin gene-related peptide-like material from the rat spinal cord in vivo.
    Brain research, 1993, Apr-23, Volume: 609, Issue:1-2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Calcitonin Gene-Related Peptide; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Spinal; Iodine Radioisotopes; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pyrrolidines; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord

1993
Involvement of delta 2 opioid receptors in acute dependence on morphine in mice.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 265, Issue:3

    Topics: Animals; Drug Interactions; Enkephalin, Leucine; Isothiocyanates; Male; Mice; Morphine; Naltrexone; Receptors, Opioid, delta; Substance-Related Disorders; Thiocyanates

1993
Dose-dependent antagonism of spinal opioid receptor agonists by naloxone and naltrindole: additional evidence for delta-opioid receptor subtypes in the rat.
    European journal of pharmacology, 1993, May-12, Volume: 236, Issue:1

    Topics: Analgesics; Animals; Binding, Competitive; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; In Vitro Techniques; Injections, Spinal; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord

1993
Modulation of morphine-induced sensitization by endogenous kappa opioid systems in the rat.
    Neuroscience letters, 1993, Apr-30, Volume: 153, Issue:2

    Topics: Animals; Dialysis; Dopamine; Injections, Intraventricular; Limbic System; Male; Morphine; Motor Activity; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa

1993
Opioid-induced suppression of rat testicular function.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 266, Issue:1

    Topics: Animals; Dose-Response Relationship, Drug; Drug Interactions; Endorphins; Extracellular Space; Gonadotropins; Hypothalamo-Hypophyseal System; Luteinizing Hormone; Male; Morphine; Naloxone; Naltrexone; Pituitary-Adrenal System; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Testis; Testosterone; Time Factors

1993
The highly selective delta agonist BUBU induces an analgesic effect in normal and arthritic rat and this action is not affected by repeated administration of low doses of morphine.
    Brain research, 1993, May-21, Volume: 611, Issue:2

    Topics: Analgesics; Animals; Arthritis, Experimental; Drug Administration Schedule; Drug Interactions; Enkephalins; Male; Morphine; Naloxone; Naltrexone; Oligopeptides; Pain; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Reference Values; Vocalization, Animal

1993
Involvement of spinal kappa opioid receptors in a type of footshock induced analgesia in mice.
    Brain research, 1993, May-21, Volume: 611, Issue:2

    Topics: Analgesia; Animals; Cerebral Ventricles; Electroshock; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Receptors, Opioid, kappa; Spinal Cord; Stress, Psychological

1993
Effects of kappa-agonist on the antinociception and locomotor enhancing action induced by morphine in mice.
    Japanese journal of pharmacology, 1993, Volume: 62, Issue:1

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzylamines; Dopamine; Dose-Response Relationship, Drug; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Narcotics; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sympathomimetics

1993
Opioid receptor regulation of 5-hydroxytryptamine release from the rat hippocampus measured by in vivo microdialysis.
    Brain research, 1993, Jun-04, Volume: 613, Issue:1

    Topics: Analgesics; Animals; Benzeneacetamides; Dialysis; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hippocampus; Male; Micromanipulation; Morphine; Naltrexone; Potassium; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid; Serotonin

1993
Selective and interactive down-regulation of mu- and delta-opioid receptors in human neuroblastoma SK-N-SH cells.
    Molecular pharmacology, 1993, Volume: 44, Issue:2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Down-Regulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Humans; Morphine; Naltrexone; Neuroblastoma; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, mu; Tumor Cells, Cultured

1993
Antitussive effects of mu- and kappa-agonists in diabetic rats.
    Neuroscience letters, 1993, May-14, Volume: 154, Issue:1-2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Antitussive Agents; Diabetes Mellitus, Experimental; Male; Morphine; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu

1993
Role of mu 1- and delta-opioid receptors in modulation of fetal EEG and respiratory activity.
    The American journal of physiology, 1993, Volume: 265, Issue:2 Pt 2

    Topics: Animals; Electroencephalography; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fetal Movement; Fetus; Morphine; Naloxone; Naltrexone; Receptors, Opioid, delta; Receptors, Opioid, mu; Respiration; Sheep

1993
Isobolographic superadditivity between delta and mu opioid agonists in the rat depends on the ratio of compounds, the mu agonist and the analgesic assay used.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 266, Issue:3

    Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Synergism; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Morphine; Naltrexone; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu

1993
Evidence for the up-regulation of kappa opiate mechanisms in mice selectively bred for high analgesia.
    Proceedings of the Western Pharmacology Society, 1993, Volume: 36

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics; Animals; Female; Mice; Morphine; Naltrexone; Pyrrolidines; Receptors, Opioid, kappa; Stress, Psychological; Swimming; Up-Regulation

1993
Dose-related antagonism of the emetic effect of morphine by methylnaltrexone in dogs.
    Journal of clinical pharmacology, 1993, Volume: 33, Issue:8

    Topics: Animals; Dogs; Dose-Response Relationship, Drug; Injections, Intramuscular; Injections, Intravenous; Male; Morphine; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Vomiting

1993
Morphine inhibits calcium influx and the response to acetylcholine in Xenopus oocytes.
    Journal of neurochemistry, 1993, Volume: 60, Issue:1

    Topics: Acetylcholine; Animals; Calcium; Diprenorphine; Electrophysiology; Female; Morphine; Muscarine; Naltrexone; Oocytes; Radioligand Assay; Xenopus laevis

1993
Effects of in vivo morphine treatment on antibody responses in C57BL/6 bgJ/bgJ (beige) mice.
    Life sciences, 1993, Volume: 52, Issue:4

    Topics: Animals; Antibody Formation; Hemolytic Plaque Technique; Immunologic Deficiency Syndromes; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Morphine; Naltrexone

1993
Effects of naltrexone on pharmacodynamics and pharmacokinetics of intravenously administered morphine in the rat.
    Pharmacology, 1993, Volume: 46, Issue:2

    Topics: Animals; Body Temperature Regulation; Injections, Intravenous; Male; Morphine; Naltrexone; Rats; Rats, Sprague-Dawley

1993
Influence of hyperkalaemia and ischaemia on non-receptor-mediated cardiac electrophysiological effects of naloxone.
    Cardiovascular research, 1993, Volume: 27, Issue:2

    Topics: Action Potentials; Animals; Culture Techniques; Dose-Response Relationship, Drug; Electrophysiology; Heart Conduction System; Hyperkalemia; Morphine; Myocardial Ischemia; Naloxone; Naltrexone; Narcotic Antagonists; Rabbits; Refractory Period, Electrophysiological

1993
Morphine-induced alterations in thymocyte subpopulations of B6C3F1 mice.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 265, Issue:1

    Topics: Animals; CD4-CD8 Ratio; Cell Death; Female; Flow Cytometry; Lymphocyte Subsets; Mice; Morphine; Naltrexone; Organ Size; Thymus Gland

1993
Perinatal morphine treatment inhibits pruning effect and regeneration of serotoninergic pathways following neonatal 5,7-HT lesions.
    Journal of neuroscience research, 1993, Mar-01, Volume: 34, Issue:4

    Topics: 5,7-Dihydroxytryptamine; Animals; Animals, Newborn; Brain Chemistry; Cerebral Cortex; Chromatography, High Pressure Liquid; Female; Hypothalamus; Immunohistochemistry; In Situ Hybridization; Morphine; Naltrexone; Nerve Regeneration; Neural Pathways; Neuronal Plasticity; Pregnancy; Rats; Rats, Sprague-Dawley; Serotonin; Spinal Cord; Sulfur Radioisotopes

1993
Naltrexone-induced alterations of the distribution of morphine in brain regions and spinal cord of the rat.
    Brain research, 1993, Apr-02, Volume: 607, Issue:1-2

    Topics: Analgesics; Animals; Body Temperature; Brain; Dose-Response Relationship, Drug; Half-Life; Injections, Intravenous; Male; Morphine; Naltrexone; Pain Measurement; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Spinal Cord

1993
Opioid and nonopioid interactions in two forms of stress-induced analgesia.
    Pharmacology, biochemistry, and behavior, 1993, Volume: 45, Issue:1

    Topics: Analgesia; Animals; Body Temperature; Cold Temperature; Male; Morphine; Naloxone; Naltrexone; Rats; Rats, Sprague-Dawley; Reaction Time; Skin Temperature; Social Behavior; Stress, Psychological

1993
Discriminative stimulus properties of morphine mediated by mu 1-opioid receptors.
    European journal of pharmacology, 1995, Sep-15, Volume: 284, Issue:1-2

    Topics: Analgesics, Opioid; Animals; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred F344; Receptors, Opioid, mu

1995
Biochemical and pharmacological characterization of multiple beta-endorphinergic antinociceptive systems in the rat periaqueductal gray.
    The Journal of pharmacology and experimental therapeutics, 1996, Volume: 276, Issue:1

    Topics: Amino Acid Sequence; Animals; beta-Endorphin; Dose-Response Relationship, Drug; Drug Interactions; Iodine Radioisotopes; Male; Molecular Sequence Data; Morphine; Naltrexone; Narcotic Antagonists; Nociceptors; Opioid Peptides; Peptide Fragments; Periaqueductal Gray; Radioligand Assay; Rats; Rats, Sprague-Dawley; Somatostatin

1996
Effects of chronic opiate and opioid antagonist treatment on striatal opioid peptides.
    Brain research, 1995, Nov-06, Volume: 698, Issue:1-2

    Topics: Amino Acid Sequence; Animals; Corpus Striatum; Endorphins; Feedback; Male; Molecular Sequence Data; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Neuropeptides; Rats; Rats, Sprague-Dawley; Substantia Nigra

1995
Morphine affects cytostatic activity of macrophages by the modulation of nitric oxide release.
    International journal of immunopharmacology, 1995, Volume: 17, Issue:9

    Topics: Analgesics, Opioid; Animals; Dexamethasone; Macrophages; Male; Mice; Mice, Inbred C57BL; Morphine; Naltrexone; Nitric Oxide; Time Factors

1995
A study of reversibly inactivated lipases for use in a morphine-triggered naltrexone delivery system.
    Journal of biomedical materials research, 1995, Volume: 29, Issue:11

    Topics: Animals; Chromobacterium; Conjugation, Genetic; Drug Implants; Enzyme Activation; Enzyme-Linked Immunosorbent Assay; Immunoconjugates; Lipase; Lipoprotein Lipase; Morphine; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Narcotics; Radioimmunoassay

1995
Differential effects of intrahypothalamic administration of opioids on food intake in naive and tolerant rats.
    Pharmacology, biochemistry, and behavior, 1995, Volume: 52, Issue:4

    Topics: Animals; Eating; Ethylketocyclazocine; Hypothalamus; Male; Morphine; Naltrexone; Narcotics; Rats; Rats, Wistar; Time Factors

1995
Biocompatibility and in vivo morphine diffusion into a placebo morphine-triggered naltrexone delivery device in rabbits.
    Biomaterials, 1995, Volume: 16, Issue:16

    Topics: Animals; Biocompatible Materials; Biotransformation; Female; Heroin Dependence; Infusion Pumps, Implantable; Injections, Intravenous; Materials Testing; Morphine; Naltrexone; Rabbits

1995
Induction of chronic Fos-related antigens in rat brain by chronic morphine administration.
    Molecular pharmacology, 1996, Volume: 49, Issue:4

    Topics: Animals; Blotting, Western; Brain; DNA-Binding Proteins; Fos-Related Antigen-2; Male; Morphine; Naltrexone; Narcotics; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Transcription Factor AP-1; Transcription Factors

1996
Assessment of the involvement of central nervous system and peripheral opioid receptors in the immunomodulatory effects of acute morphine treatment in rats.
    The Journal of pharmacology and experimental therapeutics, 1996, Volume: 276, Issue:2

    Topics: Analgesics, Opioid; Animals; Brain; Dose-Response Relationship, Drug; Immunity; Killer Cells, Natural; Lymphocyte Activation; Male; Morphine; Naltrexone; Rats; Rats, Inbred F344; Receptors, Opioid; Spleen

1996
Interaction of opioids with antidepressant-induced antinociception.
    Psychopharmacology, 1995, Volume: 122, Issue:4

    Topics: Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Clomipramine; Drug Combinations; Female; Imipramine; Male; Maprotiline; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pain Measurement; Random Allocation; Selective Serotonin Reuptake Inhibitors; Zimeldine

1995
Effects of nitric oxide-related agents on opioid regulation of rat testicular steroidogenesis.
    Biology of reproduction, 1996, Volume: 54, Issue:5

    Topics: Animals; Arginine; Chorionic Gonadotropin; Enzyme Inhibitors; Isosorbide Dinitrate; Male; Morphine; Naltrexone; Narcotic Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Testis; Testosterone

1996
Spinal cord mechanisms of opioid tolerance and dependence: Fos-like immunoreactivity increases in subpopulations of spinal cord neurons during withdrawal [corrected].
    Neuroscience, 1996, Volume: 72, Issue:1

    Topics: Analgesics, Opioid; Animals; Drug Implants; Drug Tolerance; Male; Morphine; Naltrexone; Narcotic Antagonists; Neurons; Opioid-Related Disorders; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance Withdrawal Syndrome

1996
The isolation and companion comfort responses of 7- and 3-day-old rat pups are modulated by drugs active at the opioid receptor.
    Behavioral neuroscience, 1996, Volume: 110, Issue:2

    Topics: Age Factors; Animals; Animals, Newborn; Arousal; Dose-Response Relationship, Drug; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid; Social Behavior; Social Isolation; Vocalization, Animal

1996
Differential effects of morphine-6-glucuronide, an active metabolite of morphine, and morphine on locomotor activity in mice: involvement of the opioid receptor.
    Pharmacology & toxicology, 1996, Volume: 78, Issue:5

    Topics: Animals; Injections, Subcutaneous; Locomotion; Male; Mice; Mice, Inbred Strains; Morphine; Morphine Derivatives; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid

1996
Distribution of c-Fos in guinea-pig brain following morphine withdrawal.
    Brain research, 1996, Apr-22, Volume: 717, Issue:1-2

    Topics: Analgesics, Opioid; Animals; Brain Chemistry; Female; Guinea Pigs; Locomotion; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Proto-Oncogene Proteins c-fos; Substance Withdrawal Syndrome

1996
Role of delta-opioid receptors in mediating the aversive stimulus effects of morphine withdrawal in the rat.
    European journal of pharmacology, 1996, Apr-04, Volume: 300, Issue:1-2

    Topics: Animals; Dose-Response Relationship, Drug; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Substance Withdrawal Syndrome

1996
Antinociceptive and antitussive effects of morphine in the DA-bg/bg (beige) rat.
    European journal of pharmacology, 1996, Apr-04, Volume: 300, Issue:1-2

    Topics: Analgesics, Opioid; Animals; Capsaicin; Cough; Female; Male; Morphine; Naloxone; Naltrexone; Pain; Rats; Rats, Inbred Strains; Species Specificity

1996
Morphine stimulates phagocytosis of Mycobacterium tuberculosis by human microglial cells: involvement of a G protein-coupled opiate receptor.
    Advances in neuroimmunology, 1995, Volume: 5, Issue:3

    Topics: Adjuvants, Immunologic; Brain; Cells, Cultured; Cholera Toxin; GTP-Binding Proteins; Humans; Microglia; Morphine; Mycobacterium tuberculosis; Naloxone; Naltrexone; Narcotic Antagonists; Neuroimmunomodulation; Pertussis Toxin; Phagocytosis; Receptors, Opioid; Signal Transduction; Virulence Factors, Bordetella

1995
Ontogeny of morphine withdrawal in the rat.
    Behavioral neuroscience, 1995, Volume: 109, Issue:6

    Topics: Age Factors; Animals; Arousal; Female; Humans; Infant, Newborn; Injections, Intraperitoneal; Male; Morphine; Morphine Dependence; Motor Activity; Naltrexone; Narcotic Antagonists; Neonatal Abstinence Syndrome; Neurologic Examination; Rats; Substance Withdrawal Syndrome

1995
Morphine suppresses the alloantigen-driven CTL response in a dose-dependent and naltrexone reversible manner.
    The Journal of pharmacology and experimental therapeutics, 1996, Volume: 278, Issue:2

    Topics: Animals; Dose-Response Relationship, Drug; Isoantigens; Lymphocytes; Mice; Mice, Inbred Strains; Morphine; Naltrexone; RNA

1996
Opioid antagonist profile of SC nor-binaltorphimine in the formalin paw assay.
    Pharmacology, biochemistry, and behavior, 1996, Volume: 53, Issue:2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Formaldehyde; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Pyrroles; Pyrrolidines; Receptors, Opioid, kappa; Receptors, Opioid, mu; Thiophenes

1996
Preprothyrotropin-releasing hormone mRNA in the rat central gray is strongly and persistently induced during morphine withdrawal.
    Neuropeptides, 1996, Volume: 30, Issue:3

    Topics: Analgesics, Opioid; Animals; Brain; In Situ Hybridization; Male; Mesencephalon; Morphine; Naltrexone; Narcotic Antagonists; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Substance Withdrawal Syndrome; Thalamus; Thyrotropin-Releasing Hormone; Up-Regulation

1996
Role of opioid receptors in the spinal antinociceptive effects of neuropeptide FF analogues.
    British journal of pharmacology, 1996, Volume: 117, Issue:3

    Topics: Amino Acid Sequence; Analgesics; Analgesics, Opioid; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Spinal; Male; Molecular Sequence Data; Morphine; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Somatostatin; Spinal Cord

1996
Mu- and delta-opioid receptor antagonists precipitate similar withdrawal phenomena in butorphanol and morphine dependence.
    Neurochemical research, 1996, Volume: 21, Issue:1

    Topics: Animals; Butorphanol; Drug Evaluation, Preclinical; Injections, Intraventricular; Locus Coeruleus; Male; Morphine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Somatostatin; Substance Withdrawal Syndrome

1996
Involvement of beta-endorphin in the modulation of paw inflammatory edema in the rat.
    Regulatory peptides, 1996, Jul-05, Volume: 63, Issue:2-3

    Topics: Animals; Antibodies; Benzomorphans; beta-Endorphin; Edema; Enkephalin, Leucine; Foot; Inflammation; Male; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Yeasts

1996
Effects of methylnaltrexone on morphine-induced cough suppression in guinea pigs.
    Life sciences, 1996, Volume: 59, Issue:15

    Topics: Analgesia; Animals; Antitussive Agents; Guinea Pigs; Male; Morphine; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds

1996
Opiate systems in mother and infant primates coordinate intimate contact during reunion.
    Psychoneuroendocrinology, 1995, Volume: 20, Issue:7

    Topics: Animals; Endorphins; Female; Macaca mulatta; Maternal Behavior; Maternal Deprivation; Morphine; Naltrexone; Narcotic Antagonists; Narcotics

1995
The cocaine-like behavioral effects of meperidine are mediated by activity at the dopamine transporter.
    European journal of pharmacology, 1996, Feb-15, Volume: 297, Issue:1-2

    Topics: Animals; Behavior, Animal; Carrier Proteins; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Male; Membrane Glycoproteins; Membrane Transport Proteins; Meperidine; Models, Molecular; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Nerve Tissue Proteins; Rats; Rats, Sprague-Dawley; Saimiri

1996
Effect of the highly selective and nonpeptide delta opioid receptor agonist TAN-67 on the morphine-induced place preference in mice.
    The Journal of pharmacology and experimental therapeutics, 1996, Volume: 279, Issue:1

    Topics: Analgesics; Animals; Benzylidene Compounds; Dopamine; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Limbic System; Male; Mice; Morphine; Naltrexone; Quinolines; Receptors, Opioid, delta; Reward

1996
Opiate withdrawal increases ProTRH gene expression in the ventrolateral column of the midbrain periaqueductal gray.
    Brain research, 1996, Aug-05, Volume: 729, Issue:1

    Topics: Animals; Gene Expression Regulation; Immunohistochemistry; In Situ Hybridization; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Neurons; Periaqueductal Gray; Protein Precursors; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Thyrotropin-Releasing Hormone

1996
Effects of the delta opioid against BW373U86 in pigeons trained to discriminate fentanyl, bremazocine and water in a three-choice drug discrimination procedure.
    Psychopharmacology, 1996, Volume: 126, Issue:3

    Topics: Analgesics; Animals; Benzamides; Benzomorphans; Columbidae; Discrimination, Psychological; Female; Fentanyl; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Piperazines; Receptors, Opioid, delta

1996
The NMDA receptor antagonist MK-801 differentially modulates mu and kappa opioid actions in spinal cord in vitro.
    Pain, 1996, Volume: 66, Issue:2-3

    Topics: Analgesics; Animals; Animals, Newborn; Benzeneacetamides; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; In Vitro Techniques; Membrane Potentials; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord

1996
Induction of Fos-like immunoreactivity by opioids in guinea-pig brain.
    Brain research, 1996, Aug-26, Volume: 731, Issue:1-2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Opioid; Animals; Brain Chemistry; Diencephalon; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Guinea Pigs; Immunohistochemistry; Injections, Intraventricular; Male; Mesencephalon; Morphine; Naltrexone; Narcotic Antagonists; Neurons; Proto-Oncogene Proteins c-fos; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Telencephalon

1996
Effects of selective opioid receptor antagonists on morphine-induced changes in striatal and limbic dopamine metabolism.
    Pharmacology & toxicology, 1995, Volume: 77, Issue:3

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Dopamine; Homovanillic Acid; Injections, Intraperitoneal; Injections, Intraventricular; Limbic System; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pain Threshold; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu

1995
The effects of morphine on carrageenin-induced spinal c-Fos expression are completely blocked by beta-funaltrexamine, a selective mu-opioid receptor antagonist.
    Brain research, 1996, Sep-02, Volume: 732, Issue:1-2

    Topics: Animals; Carrageenan; Gene Expression; Male; Morphine; Naltrexone; Narcotic Antagonists; Neurons; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Spinal Cord

1996
Sensitization of the tail-flick reflex following exposure to either a single prolonged test trial or behavioral testing under the analgesic influence of morphine.
    Pain, 1996, Volume: 67, Issue:1

    Topics: Analgesics, Opioid; Animals; Behavior, Animal; Body Temperature; Hot Temperature; Hyperalgesia; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain Threshold; Physical Stimulation; Rats; Rats, Sprague-Dawley; Reaction Time; Reflex; Restraint, Physical; Tail; Time Factors

1996
A selective AMPA antagonist, LY293558, suppresses morphine withdrawal-induced activation of locus coeruleus neurons and behavioral signs of morphine withdrawal.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1996, Volume: 15, Issue:5

    Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Electrophysiology; In Vitro Techniques; Isoquinolines; Locus Coeruleus; Male; Morphine; Naltrexone; Narcotics; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Substance Withdrawal Syndrome; Tetrazoles

1996
Use of a mu-antisense oligodeoxynucleotide as a mu opioid receptor noncompetitive antagonist in vivo.
    Neurochemical research, 1996, Volume: 21, Issue:11

    Topics: Animals; Base Sequence; Cerebral Ventricles; Injections, Intraventricular; Injections, Subcutaneous; Male; Molecular Sequence Data; Morphine; Naltrexone; Narcotic Antagonists; Oligonucleotides, Antisense; Pain; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid, mu

1996
Further evidence for a peripheral component in the enhanced antinociceptive effect of systemic morphine in mononeuropathic rats: involvement of kappa-, but not delta-opioid receptors.
    European journal of pharmacology, 1996, Nov-14, Volume: 315, Issue:2

    Topics: Analgesia; Animals; Constriction; Drug Interactions; Injections, Intravenous; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Sciatic Nerve; Vocalization, Animal

1996
Cancer pain remedy wins orphan drug status.
    Oncology (Williston Park, N.Y.), 1996, Volume: 10, Issue:12

    Topics: Blood-Brain Barrier; Constipation; Drug Therapy, Combination; Humans; Morphine; Naltrexone; Narcotic Antagonists; Nausea; Neoplasms; Orphan Drug Production; Pain; Quaternary Ammonium Compounds; United States; United States Food and Drug Administration

1996
Acute pulmonary edema in a young male after intravenous nalmefene.
    Anesthesia and analgesia, 1997, Volume: 84, Issue:1

    Topics: Acute Disease; Adult; Analgesics, Opioid; Anesthesia; Humans; Infusions, Intravenous; Male; Morphine; Naltrexone; Narcotic Antagonists; Pulmonary Edema

1997
Opiate effects on 5-fluorouracil disposition in mice.
    Cancer chemotherapy and pharmacology, 1997, Volume: 39, Issue:3

    Topics: Analgesics, Opioid; Animals; Antimetabolites, Antineoplastic; Drug Interactions; Female; Fluorouracil; Liver; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone

1997
Monoamine metabolism in the locus coeruleus measured concurrently with behavior during opiate withdrawal: an in vivo microdialysis study in freely moving rats.
    Journal of neurochemistry, 1997, Volume: 68, Issue:2

    Topics: 3,4-Dihydroxyphenylacetic Acid; Analgesics, Opioid; Animals; Behavior, Animal; Biogenic Monoamines; Hydroxyindoleacetic Acid; Locus Coeruleus; Male; Microdialysis; Monoamine Oxidase Inhibitors; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Pargyline; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome

1997
Potentiation of delta 9-tetrahydrocannabinol-induced analgesia by morphine in mice: involvement of mu- and kappa-opioid receptors.
    European journal of pharmacology, 1996, Dec-27, Volume: 318, Issue:1

    Topics: Analgesia; Analgesics, Opioid; Animals; Binding Sites; Dronabinol; Drug Synergism; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Pain Measurement; Receptors, Opioid, kappa; Receptors, Opioid, mu

1996
Opioid stimulation in the ventral tegmental area facilitates the onset of maternal behavior in rats.
    Brain research, 1996, Dec-16, Volume: 743, Issue:1-2

    Topics: Analgesics, Opioid; Analysis of Variance; Animals; Female; Maternal Behavior; Morphine; Naltrexone; Narcotic Antagonists; Rats; Reaction Time; Stimulation, Chemical; Ventral Tegmental Area

1996
Reversal by kappa-agonists of peritoneal irritation-induced ileus and visceral pain in rats.
    Life sciences, 1997, Volume: 60, Issue:9

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetic Acid; Analgesics; Animals; Benzofurans; Benzomorphans; Cyclazocine; Fentanyl; Gastric Emptying; Intestinal Pseudo-Obstruction; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Peritoneum; Pyrroles; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Thiophenes

1997
Blockade of morphine supersensitivity by an antisense oligodeoxynucleotide targeting the delta opioid receptor (DOR-1).
    Life sciences, 1997, Volume: 60, Issue:9

    Topics: Analgesics; Animals; Base Sequence; Drug Tolerance; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Oligonucleotides, Antisense; Receptors, Opioid, delta

1997
Influence of chronic prenatal and postnatal administration of naltrexone in locomotor activity induced by morphine in mice.
    Archives of medical research, 1997,Spring, Volume: 28, Issue:1

    Topics: Amphetamine; Animals; Animals, Newborn; Animals, Suckling; Dose-Response Relationship, Drug; Drug Resistance; Female; Fetus; Hyperkinesis; Locomotion; Male; Maternal-Fetal Exchange; Mice; Mice, Inbred C57BL; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Pregnancy; Prenatal Exposure Delayed Effects; Receptors, Opioid

1997
Nalbuphine coadministered with morphine prevents tolerance and dependence.
    Anesthesia and analgesia, 1997, Volume: 84, Issue:4

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Therapy, Combination; Drug Tolerance; Male; Morphine; Nalbuphine; Naloxone; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Pyrrolidines; Rats; Rats, Sprague-Dawley

1997
Intracranial self-stimulation in rats: sensitization to an opioid antagonist following acute or chronic treatment with mu opioid agonists.
    The Journal of pharmacology and experimental therapeutics, 1997, Volume: 281, Issue:1

    Topics: Animals; Brain; Dose-Response Relationship, Drug; Electric Stimulation; Male; Morphine; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Self Stimulation

1997
Chronic morphine and naltrexone fail to modify mu-opioid receptor mRNA levels in the rat brain.
    Brain research. Molecular brain research, 1997, Volume: 45, Issue:1

    Topics: Animals; Brain; Corpus Striatum; DNA Primers; Drug Administration Schedule; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Morphine; Naltrexone; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; RNA, Messenger; Substance Withdrawal Syndrome

1997
Inhibition of swine microglial cell phagocytosis of Cryptococcus neoformans by femtomolar concentrations of morphine.
    Biochemical pharmacology, 1997, Mar-21, Volume: 53, Issue:6

    Topics: Animals; Cryptococcus neoformans; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; GTP-Binding Proteins; Microglia; Morphine; Naltrexone; Narcotics; Phagocytosis; Swine

1997
Increased release of excitatory amino acids in rat locus coeruleus in kappa-opioid agonist dependent rats precipitated by nor-binaltorphimine.
    Brain research, 1997, Apr-04, Volume: 753, Issue:1

    Topics: Animals; Benzeneacetamides; Butorphanol; Drug Evaluation, Preclinical; Excitatory Amino Acids; Locus Coeruleus; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Substance Withdrawal Syndrome; Substance-Related Disorders

1997
Evidence for roles of kappa-opioid and NMDA receptors in the mechanism of action of ibogaine.
    Brain research, 1997, Feb-28, Volume: 749, Issue:2

    Topics: Animals; Corpus Striatum; Dopamine; Female; Ibogaine; Morphine; Motor Activity; N-Methylaspartate; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa; Self Administration; Substance-Related Disorders

1997
Distinct components of morphine effects on cardiac myocytes are mediated by the kappa and delta opioid receptors.
    Journal of molecular and cellular cardiology, 1997, Volume: 29, Issue:2

    Topics: Analgesics, Opioid; Animals; Animals, Newborn; Calcium; Cells, Cultured; Heart; Heart Ventricles; Morphine; Myocardial Contraction; Myocardium; Naltrexone; Narcotic Antagonists; Rats; Receptors, Opioid, delta; Receptors, Opioid, kappa

1997
Neuropeptide FF in the rat spinal cord during carrageenan inflammation.
    Peptides, 1997, Volume: 18, Issue:2

    Topics: Animals; Carrageenan; Hot Temperature; Inflammation; Male; Morphine; Naltrexone; Narcotic Antagonists; Neurons; Neuropeptides; Oligopeptides; Pain; Rats; Rats, Sprague-Dawley; Spinal Cord

1997
Antagonism of the response rate-decreasing effects of meperidine and morphine by beta-funaltrexamine and naltrexone in squirrel monkeys.
    Drug and alcohol dependence, 1997, May-02, Volume: 45, Issue:3

    Topics: Animals; Conditioning, Operant; Dose-Response Relationship, Drug; Feeding Behavior; Longitudinal Studies; Male; Meperidine; Morphine; Naltrexone; Narcotic Antagonists; Reinforcement, Psychology; Saimiri

1997
Differential effects of naltrindole on morphine-induced tolerance and physical dependence in rats.
    The Journal of pharmacology and experimental therapeutics, 1997, Volume: 281, Issue:3

    Topics: Animals; Drug Tolerance; Female; Male; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Substance-Related Disorders

1997
Interactions between alcohol- and opioid-induced suppression of rat testicular steroidogenesis in vivo.
    Alcoholism, clinical and experimental research, 1997, Volume: 21, Issue:4

    Topics: Alcoholism; Animals; Dose-Response Relationship, Drug; Ethanol; Luteinizing Hormone; Male; Morphine; Naltrexone; Narcotic Antagonists; Opioid Peptides; Rats; Testis; Testosterone

1997
Ultra-low doses of naltrexone or etorphine increase morphine's antinociceptive potency and attenuate tolerance/dependence in mice.
    Brain research, 1997, May-23, Volume: 757, Issue:2

    Topics: Administration, Oral; Analgesics, Opioid; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Tolerance; Etorphine; Infusions, Parenteral; Male; Mice; Mice, Inbred Strains; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Narcotics; Nociceptors; Substance Withdrawal Syndrome; Substance-Related Disorders

1997
Morphine induces sepsis in mice.
    The Journal of infectious diseases, 1997, Volume: 176, Issue:1

    Topics: Analgesics, Opioid; Animals; Female; Lipopolysaccharides; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Morphine; Naltrexone; Sepsis

1997
Antinociceptive and immunosuppressive effects of opiate drugs: a structure-related activity study.
    British journal of pharmacology, 1997, Volume: 121, Issue:4

    Topics: Animals; Cell Division; Codeine; Hydromorphone; Immune System; Immunosuppression Therapy; Interleukin-2; Male; Mice; Morphine; Nalorphine; Naloxone; Naltrexone; Narcotics; Oxycodone; Structure-Activity Relationship

1997
Ventilation in morphine-maintained rhesus monkeys. I: Effects of naltrexone and abstinence-associated withdrawal.
    The Journal of pharmacology and experimental therapeutics, 1997, Volume: 282, Issue:1

    Topics: Animals; Dose-Response Relationship, Drug; Female; Macaca mulatta; Male; Morphine; Naltrexone; Narcotics; Respiration; Substance Withdrawal Syndrome

1997
In vivo binding of [125I]NH2-carfentanil to mu opioid receptors in mouse brain.
    Nuclear medicine and biology, 1994, Volume: 21, Issue:2

    Topics: Animals; Autoradiography; Brain; Fentanyl; Injections, Intraperitoneal; Iodine Radioisotopes; Logistic Models; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Radioligand Assay; Receptors, Opioid, mu

1994
Time course of the changes in central nitric oxide synthase activity following chronic treatment with morphine in the mouse: reversal by naltrexone.
    General pharmacology, 1997, Volume: 29, Issue:2

    Topics: Animals; Brain; Kinetics; Male; Mice; Morphine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Nitric Oxide Synthase; Spinal Cord

1997
3-Methoxynaltrexone, a selective heroin/morphine-6beta-glucuronide antagonist.
    FEBS letters, 1997, Jul-21, Volume: 412, Issue:1

    Topics: Analgesia; Animals; Binding Sites; Binding, Competitive; CHO Cells; Cricetinae; Heroin; Male; Mice; Morphine; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu; Transfection; Tritium

1997
Antagonism of morphine-like discriminative effects by beta-funaltrexamine.
    Pharmacology, biochemistry, and behavior, 1997, Volume: 57, Issue:4

    Topics: Analgesics, Opioid; Animals; Buprenorphine; Cisterna Magna; Discrimination Learning; Fentanyl; Injections; Male; Meperidine; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu

1997
Precipitated morphine withdrawal induces a conditioned aversion in the preweaning rat.
    Pharmacology, biochemistry, and behavior, 1997, Volume: 57, Issue:4

    Topics: Animals; Animals, Newborn; Avoidance Learning; Conditioning, Psychological; Female; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Smell; Substance Withdrawal Syndrome

1997
Discriminative stimulus effects of l-alpha-acetylmethadol (LAAM), buprenorphine and methadone in morphine-treated rhesus monkeys.
    The Journal of pharmacology and experimental therapeutics, 1997, Volume: 282, Issue:2

    Topics: Animals; Buprenorphine; Discrimination, Psychological; Dose-Response Relationship, Drug; Female; Macaca mulatta; Male; Methadone; Methadyl Acetate; Morphine; Naltrexone; Narcotic Antagonists; Narcotics

1997
Effects of opioids on the absorption of alcohol.
    Pharmacology, biochemistry, and behavior, 1997, Volume: 58, Issue:1

    Topics: Analgesics, Opioid; Animals; Central Nervous System Depressants; Dose-Response Relationship, Drug; Ethanol; Gastrointestinal Agents; Injections, Intraperitoneal; Injections, Subcutaneous; Intestinal Absorption; Loperamide; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Wistar

1997
The analgesia-enhancing component of ingested amniotic fluid does not affect nicotine-induced antinociception in naltrexone-treated rats.
    Pharmacology, biochemistry, and behavior, 1997, Volume: 58, Issue:1

    Topics: Amniotic Fluid; Analgesia; Analgesics; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Female; Morphine; Naltrexone; Narcotic Antagonists; Nicotine; Nicotinic Agonists; Pain Measurement; Pregnancy; Rats; Reaction Time

1997
Involvement of opioid mu 1 receptors in morphine-induced conditioned place preference in rats.
    Pharmacology, biochemistry, and behavior, 1997, Volume: 58, Issue:1

    Topics: Analgesics, Opioid; Animals; Body Temperature; Catalepsy; Conditioning, Operant; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Rats; Rats, Wistar; Receptors, Opioid, mu

1997
Supraspinal administration of opioids with selectivity for mu-, delta- and kappa-opioid receptors produces analgesia in amphibians.
    European journal of pharmacology, 1997, Jul-16, Volume: 331, Issue:1

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Benzofurans; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Female; Fentanyl; Injections, Intraventricular; Male; Morphine; Naltrexone; Narcotics; Pyrrolidines; Rana pipiens; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu

1997
Ischemic preconditioning and morphine-induced cardioprotection involve the delta (delta)-opioid receptor in the intact rat heart.
    Journal of molecular and cellular cardiology, 1997, Volume: 29, Issue:8

    Topics: Animals; Cardiovascular Agents; Heart; Ischemic Preconditioning, Myocardial; Male; Morphine; Myocardial Infarction; Myocardium; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid, delta; Thiopental

1997
A possible new treatment approach to obsessive-compulsive disorder.
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1997, Volume: 42, Issue:6

    Topics: Adult; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Middle Aged; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Obsessive-Compulsive Disorder

1997
Effects of naltrexone and cross-tolerance to morphine in a learned helplessness paradigm.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 1997, Volume: 30, Issue:6

    Topics: Analgesia; Analgesics, Opioid; Animals; Drug Tolerance; Female; Helplessness, Learned; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar

1997
Butorphanol-mediated antinociception in mice: partial agonist effects and mu receptor involvement.
    The Journal of pharmacology and experimental therapeutics, 1997, Volume: 282, Issue:3

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Butorphanol; Male; Mice; Morphine; Naltrexone; Pyrrolidines; Receptors, Opioid, mu

1997
Antinociceptive effects of morphine and U-50,488H on vaginal distension in the anesthetized rat.
    Life sciences, 1997, Volume: 61, Issue:16

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia; Animals; Blood Pressure; Cardiovascular System; Estrus; Female; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vaginal Diseases

1997
Spinal mu, delta and kappa opioids alter chemical, mechanical and thermal sensitivities in amphibians.
    Life sciences, 1997, Volume: 61, Issue:22

    Topics: Analgesics, Opioid; Animals; Drug Interactions; Enkephalin, Leucine-2-Alanine; Fentanyl; Injections, Spinal; Morphine; Naltrexone; Narcotic Antagonists; Nociceptors; Pain Measurement; Pain Threshold; Rana pipiens; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sensitivity and Specificity; Spinal Cord

1997
Characterization of opiate binding sites on the goldfish (Carassius auratus L.) pronephric leukocytes.
    Polish journal of pharmacology, 1997, Volume: 49, Issue:4

    Topics: Animals; Binding Sites; Goldfish; Leukocytes; Morphinans; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Receptors, Opioid, mu

1997
Opioid receptor blockade throughout prenatal life confers long-term insensitivity to morphine and alters mu opioid receptors.
    Pharmacology, biochemistry, and behavior, 1998, Volume: 59, Issue:1

    Topics: Analgesics, Opioid; Animals; Body Weight; Female; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu

1998
Nalmefene and the urine opiate screen.
    Clinical chemistry, 1998, Volume: 44, Issue:2

    Topics: Adult; Cross Reactions; Drug Evaluation, Preclinical; False Positive Reactions; Humans; Immunoassay; Molecular Structure; Morphine; Naltrexone; Narcotics

1998
Differential involvement of opioid receptors in intrathecal butorphanol-induced analgesia: compared to morphine.
    Pharmacology, biochemistry, and behavior, 1998, Volume: 59, Issue:3

    Topics: Analgesics, Opioid; Animals; Butorphanol; Dose-Response Relationship, Drug; Injections, Spinal; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid

1998
Establishing morphine and U-50,488H as discriminative stimuli in a three-choice assay with pigeons.
    Experimental and clinical psychopharmacology, 1998, Volume: 6, Issue:1

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Columbidae; Dextroamphetamine; Discrimination Learning; Discrimination, Psychological; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Ethylketocyclazocine; Generalization, Response; Morphine; Naltrexone; Narcotic Antagonists; Narcotics

1998
Morphine-6-glucuronide-induced locomotor stimulation in mice: role of opioid receptors.
    Pharmacology & toxicology, 1998, Volume: 82, Issue:1

    Topics: Analgesics, Opioid; Analysis of Variance; Animals; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred C57BL; Morphine; Morphine Derivatives; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid

1998
[125I-Tyr1]biphalin binding to opioid receptors of rat brain and NG108-15 cell membranes.
    Life sciences, 1998, Volume: 62, Issue:14

    Topics: Animals; Brain; Cell Line; Cell Membrane; Enkephalins; Iodine Radioisotopes; Morphine; Naltrexone; Narcotic Antagonists; Oligopeptides; Radioligand Assay; Rats; Receptors, Opioid

1998
Differential modulation of mu- and delta-opioid antinociception by neuropeptide FF receptors in young mice.
    Neuropeptides, 1997, Volume: 31, Issue:1

    Topics: Age Factors; Analgesics, Opioid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Mice; Mice, Inbred Strains; Morphine; Naltrexone; Narcotic Antagonists; Neuropeptides; Nociceptors; Oligopeptides; Receptors, Neuropeptide; Receptors, Opioid, delta; Receptors, Opioid, mu

1997
Influence of oral buprenorphine, oral naltrexone or morphine on the effects of laparotomy in the rat.
    Laboratory animals, 1998, Volume: 32, Issue:2

    Topics: Administration, Oral; Analgesics, Opioid; Animals; Behavior, Animal; Body Weight; Buprenorphine; Drinking; Eating; Laparotomy; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain, Postoperative; Rats; Rats, Wistar; Specific Pathogen-Free Organisms

1998
Activation of coeruleospinal noradrenergic inhibitory controls during withdrawal from morphine in the rat.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998, Jun-01, Volume: 18, Issue:11

    Topics: Animals; Antibodies, Monoclonal; Efferent Pathways; Immunotoxins; Locus Coeruleus; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Neural Inhibition; Norepinephrine; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Ribosome Inactivating Proteins, Type 1; Saporins; Spinal Cord; Substance Withdrawal Syndrome

1998
Role of central opioid receptor subtypes in morphine-induced alterations in peripheral lymphocyte activity.
    Brain research, 1998, Apr-06, Volume: 789, Issue:1

    Topics: Analgesics, Opioid; Animals; Brain; Cell Division; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intraventricular; Lymphocytes; Male; Morphine; Naltrexone; Narcotic Antagonists; Nociceptors; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu

1998
Supraspinal flumazenil inhibits the antianalgesic action of spinal dynorphin A (1-17).
    Pharmacology, biochemistry, and behavior, 1998, Volume: 60, Issue:1

    Topics: Analgesia; Analgesics; Animals; Clonidine; Dose-Response Relationship, Drug; Drug Interactions; Dynorphins; Flumazenil; GABA Agonists; GABA-A Receptor Agonists; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Naltrexone; Physostigmine

1998
Antinociceptive effects of the novel neuronal nicotinic acetylcholine receptor agonist, ABT-594, in mice.
    European journal of pharmacology, 1998, Apr-03, Volume: 346, Issue:1

    Topics: Analgesics, Non-Narcotic; Animals; Azetidines; Hexamethonium; Lethal Dose 50; Male; Maze Learning; Mecamylamine; Mice; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Neurons; Nicotinic Agonists; Nicotinic Antagonists; Pain; Pyridines

1998
Studies on benzodiazepines and opioids administered alone and in combination in rhesus monkeys: ventilation and drug discrimination.
    Psychopharmacology, 1998, Volume: 137, Issue:2

    Topics: Animals; Benzodiazepines; Discrimination Learning; Dose-Response Relationship, Drug; Drug Synergism; Female; Flumazenil; Macaca mulatta; Male; Midazolam; Morphine; Naltrexone; Narcotics; Respiration

1998
The rate-decreasing effects of fentanyl derivatives in pigeons before, during and after chronic morphine treatment.
    Psychopharmacology, 1998, Volume: 137, Issue:1

    Topics: Analgesics; Animals; Columbidae; Conditioning, Psychological; Dose-Response Relationship, Drug; Drug Tolerance; Fentanyl; Morphine; Naltrexone

1998
Interactions between N-methyl-D-aspartate receptor antagonists and the discriminative stimulus effects of morphine in rats.
    Pharmacology, biochemistry, and behavior, 1998, Volume: 60, Issue:2

    Topics: Animals; Binding, Competitive; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Generalization, Stimulus; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate

1998
Alteration in regulation of serotonin release in rat dorsal raphe nucleus after prolonged exposure to morphine.
    The Journal of pharmacology and experimental therapeutics, 1998, Volume: 286, Issue:1

    Topics: Animals; Drug Tolerance; Male; Morphine; Naltrexone; Narcotics; Opioid-Related Disorders; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Serotonin

1998
The expression of interleukin-1-beta converting enzyme (ICE) in rat is decreased following chronic exposure to morphine.
    Advances in experimental medicine and biology, 1998, Volume: 437

    Topics: Animals; Brain; Caspase 1; Cysteine Endopeptidases; Drug Interactions; Interleukin-1; Male; Morphine; Naltrexone; Narcotic Antagonists; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; Spleen

1998
NTI4F: a non-peptide fluorescent probe selective for functional delta opioid receptors.
    Neuroscience letters, 1998, Jun-19, Volume: 249, Issue:2-3

    Topics: Animals; Bridged-Ring Compounds; Cell Line; Dogs; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Fluorescent Dyes; Imides; Microscopy, Confocal; Microscopy, Fluorescence; Morphine; Naltrexone; Receptors, Opioid, delta; Transfection

1998
Beta-funaltrexamine discriminates between two subtypes of mu2-opioid receptors in electrically stimulated longitudinal muscle of guinea pig ileum.
    General pharmacology, 1998, Volume: 31, Issue:2

    Topics: Acetylcholine; Animals; Binding, Competitive; Electric Stimulation; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists; Nerve Endings; Receptors, Opioid, mu; Tetrodotoxin

1998
Involvement of mu- and delta-opioid receptors in the ethanol-associated place preference in rats exposed to foot shock stress.
    Brain research, 1998, Aug-24, Volume: 803, Issue:1-2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Ethanol; Exploratory Behavior; Foot; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Morphine; Naloxone; Naltrexone; Narcotics; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu

1998
Prevention of apomorphine- or cisplatin-induced emesis in the dog by a combination of methylnaltrexone and morphine.
    Cancer chemotherapy and pharmacology, 1998, Volume: 42, Issue:4

    Topics: Administration, Oral; Animals; Antiemetics; Antineoplastic Agents; Apomorphine; Cisplatin; Dogs; Drug Interactions; Drug Therapy, Combination; Emetics; Male; Morphine; Naltrexone; Narcotics; Quaternary Ammonium Compounds; Vomiting

1998
Apparent thermodynamic parameters of ligand binding to the cloned rat mu-opioid receptor.
    European journal of pharmacology, 1998, Aug-07, Volume: 354, Issue:2-3

    Topics: Analgesics; Animals; Binding, Competitive; CHO Cells; Cricetinae; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Fentanyl; Ligands; Methadone; Morphine; Naltrexone; Narcotic Antagonists; Pentazocine; Peptide Fragments; Peptides; Radioligand Assay; Rats; Receptors, Opioid, mu; Somatostatin; Sufentanil; Thermodynamics; Time Factors

1998
MU-opioid receptor-knockout mice: role of mu-opioid receptor in morphine mediated immune functions.
    Brain research. Molecular brain research, 1998, Oct-30, Volume: 61, Issue:1-2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Binding, Competitive; Disease Models, Animal; Drug Implants; Exons; Gene Targeting; Immune System; Immunosuppression Therapy; Interleukin-2; Ligands; Macrophage Activation; Macrophages, Peritoneal; Mice; Mice, Knockout; Mitogens; Morphine; Naltrexone; Organ Size; Phagocytosis; Receptors, Opioid, mu; Spleen; Substance-Related Disorders; Thymidine; Thymus Gland; Tumor Necrosis Factor-alpha

1998
The mu opioid irreversible antagonist beta-funaltrexamine differentiates the discriminative stimulus effects of opioids with high and low efficacy at the mu opioid receptor.
    Psychopharmacology, 1998, Volume: 140, Issue:1

    Topics: Animals; Buprenorphine; Butorphanol; Columbidae; Discrimination Learning; Female; Fentanyl; Levallorphan; Methadone; Morphine; Nalbuphine; Nalorphine; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu

1998
Comparison of the discriminative and antinociceptive effects of morphine and its glucuronide metabolites after central or systemic administration in the rat.
    Psychopharmacology, 1998, Volume: 140, Issue:1

    Topics: Analgesics, Opioid; Animals; Discrimination Learning; Dose-Response Relationship, Drug; Injections, Intraventricular; Injections, Subcutaneous; Male; Morphine; Morphine Derivatives; Naltrexone; Rats; Rats, Sprague-Dawley

1998
Validation study of the conductometrical analysis. Application to the drug release studies from controlled release systems.
    Journal of pharmaceutical and biomedical analysis, 1998, Volume: 18, Issue:1-2

    Topics: Conductometry; Delayed-Action Preparations; Morphine; Naltrexone; Reproducibility of Results

1998
Peripheral effects of opioids in a model of chronic intestinal inflammation in mice.
    The Journal of pharmacology and experimental therapeutics, 1998, Volume: 287, Issue:3

    Topics: Animals; Antidiarrheals; Body Weight; Carbon Monoxide; Enteritis; Gastrointestinal Transit; Jejunum; Loperamide; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Receptors, Opioid

1998
Opioid antagonist modulation of ischaemia-induced ventricular arrhythmias: a peripheral mechanism.
    Journal of cardiovascular pharmacology, 1999, Volume: 33, Issue:1

    Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Cardiovascular System; Coronary Disease; Drug Interactions; Heart Rate; Morphine; Myocardial Reperfusion Injury; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Rabbits

1999
The effects of morphine, nicotine and epibatidine on lymphocyte activity and hypothalamic-pituitary-adrenal axis responses.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 288, Issue:2

    Topics: Adjuvants, Immunologic; Analgesics, Opioid; Animals; Bridged Bicyclo Compounds, Heterocyclic; Chlorisondamine; Dose-Response Relationship, Drug; Drug Interactions; Hypothalamo-Hypophyseal System; Lymphocyte Activation; Male; Morphine; Naltrexone; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pituitary-Adrenal System; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Receptors, Opioid; T-Lymphocytes

1999
Heroin antinociception changed from mu to delta receptor in streptozotocin-treated mice.
    Japanese journal of pharmacology, 1998, Volume: 78, Issue:4

    Topics: Analgesics, Opioid; Animals; Anti-Bacterial Agents; Benzylidene Compounds; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Heroin; Injections, Intraventricular; Male; Mice; Morphine; Morphine Derivatives; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Pain; Receptors, Opioid, delta; Receptors, Opioid, mu; Streptozocin; Time Factors

1998
Effects of test conditions on the outcome of place conditioning with morphine and naltrexone in mice.
    Psychopharmacology, 1999, Volume: 141, Issue:2

    Topics: Animals; Conditioning, Psychological; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists

1999
Chronic naltrindole administration does not modify the inhibitory effect of morphine on vocalization responses in the tail electric stimulation test in rats.
    Neuroscience letters, 1999, Jan-29, Volume: 260, Issue:2

    Topics: Albinism; Animals; Electric Stimulation; Male; Morphine; Movement; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Tail; Vocalization, Animal

1999
Role of the kappa-opioid system in the attenuation of the morphine-induced place preference under chronic pain.
    Life sciences, 1999, Volume: 64, Issue:1

    Topics: Animals; Chronic Disease; Conditioning, Psychological; Formaldehyde; Hindlimb; Inflammation; Male; Morphine; Naltrexone; Pain; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Reward; Time Factors

1999
Discriminative stimulus effects of naltrexone after a single dose of morphine in the rat.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 288, Issue:3

    Topics: Animals; Discrimination Learning; Dose-Response Relationship, Drug; Drug Interactions; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Sprague-Dawley; Time Factors

1999
Effect of gonadectomy on discriminative stimulus effects of morphine in female versus male rats.
    Drug and alcohol dependence, 1999, Jan-07, Volume: 53, Issue:2

    Topics: Animals; Buprenorphine; Castration; Discrimination Learning; Female; Fentanyl; Gonadal Steroid Hormones; Injections; Male; Morphine; Nalbuphine; Naltrexone; Narcotic Antagonists; Narcotics; Nociceptors; Rats; Rats, Sprague-Dawley; Sex Characteristics

1999
Effects of opioid receptor antagonists on the effects of i.v. morphine on carrageenin evoked c-Fos expression in the superficial dorsal horn of the rat spinal cord.
    Brain research, 1999, Apr-03, Volume: 824, Issue:1

    Topics: Analgesics, Opioid; Animals; Carrageenan; Hindlimb; Inflammation; Injections, Intravenous; Male; Morphine; Naltrexone; Narcotic Antagonists; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin; Spinal Cord

1999
Different roles of mu-, delta- and kappa-opioid receptors in ethanol-associated place preference in rats exposed to conditioned fear stress.
    European journal of pharmacology, 1999, Feb-26, Volume: 368, Issue:1

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Behavior, Animal; Central Nervous System Depressants; Conditioning, Psychological; Ethanol; Fear; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stress, Psychological

1999
A morphine-triggered delivery system useful in the treatment of heroin addiction.
    Clinical materials, 1993, Volume: 13, Issue:1-4

    Topics: Biodegradation, Environmental; Drug Delivery Systems; Heroin Dependence; Humans; Lipase; Materials Testing; Membranes, Artificial; Microspheres; Molecular Structure; Morphine; Naltrexone; Polymers; Porosity

1993
[A molecular mechanism for supersensitization of adenylyl cyclase system in cloned opioid receptor-transfected cells following sustained opioid treatment].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1998, Volume: 112 Suppl 1

    Topics: Adenylyl Cyclases; Analgesics; Animals; Atropine; Benzeneacetamides; Carbachol; CHO Cells; Clone Cells; Cricetinae; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP Phosphohydrolases; Morphine; Muscarinic Agonists; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Transfection

1998
The importance of the number of NMDA receptors in the development of supersensitivity or tolerance to and dependence on morphine.
    Pharmacological research, 1999, Volume: 39, Issue:4

    Topics: Analgesics, Opioid; Animals; Brain; Dizocilpine Maleate; Drug Tolerance; Excitatory Amino Acid Antagonists; Kinetics; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain Measurement; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Substance-Related Disorders

1999
The selective mGlu2/3 receptor agonist LY354740 attenuates morphine-withdrawal-induced activation of locus coeruleus neurons and behavioral signs of morphine withdrawal.
    Neuropharmacology, 1999, Volume: 38, Issue:2

    Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Bridged Bicyclo Compounds; Electrophysiology; Excitatory Amino Acid Agonists; Locus Coeruleus; Male; Membrane Potentials; Morphine; Morphine Dependence; Naltrexone; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Substance Withdrawal Syndrome

1999
Gastric effects of methylnaltrexone on mu, kappa, and delta opioid agonists induced brainstem unitary responses.
    Neuropharmacology, 1999, Volume: 38, Issue:3

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Animals, Newborn; Brain Stem; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Morphine; Naltrexone; Narcotic Antagonists; Neurons; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Solitary Nucleus; Stomach; Vagus Nerve

1999
Evaluation of hypothermia-induced analgesia and influence of opioid antagonists in leopard frogs (Rana pipiens).
    Pharmacology, biochemistry, and behavior, 1999, Volume: 63, Issue:1

    Topics: Analgesia; Analgesics, Opioid; Animals; Evaluation Studies as Topic; Hypothermia, Induced; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rana pipiens

1999
Isolation reduces contextual but not auditory-cue fear conditioning: a role for endogenous opioids.
    Behavioral neuroscience, 1999, Volume: 113, Issue:2

    Topics: Analysis of Variance; Animals; Avoidance Learning; Conditioning, Classical; Cues; Fear; Female; Male; Morphine; Naltrexone; Narcotic Antagonists; Opioid Peptides; Rats; Rats, Long-Evans; Social Isolation

1999
Direct preconditioning of cardiac myocytes via opioid receptors and KATP channels.
    Circulation research, 1999, Jun-25, Volume: 84, Issue:12

    Topics: Adenosine Triphosphate; Analgesics, Opioid; Animals; Anti-Arrhythmia Agents; Benzylidene Compounds; Cells, Cultured; Chick Embryo; Decanoic Acids; Hydroxy Acids; Ischemic Preconditioning, Myocardial; Morphine; Muscle Fibers, Skeletal; Myocardium; Naloxone; Naltrexone; Narcotic Antagonists; Potassium Channels; Receptors, Opioid

1999
The discriminative stimulus effects of naloxone and naltrexone in morphine-treated rhesus monkeys: comparison of oral and subcutaneous administration.
    Psychopharmacology, 1999, Volume: 144, Issue:2

    Topics: Animals; Discrimination Learning; Female; Macaca mulatta; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics

1999
Supersensitization of the adenylyl cyclase system in Chinese hamster ovary cells co-expressing cloned opioid receptors and Gz, a PTX-insensitive G protein.
    Neuroscience letters, 1999, May-28, Volume: 267, Issue:2

    Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Benzeneacetamides; CHO Cells; Cricetinae; Cyclic AMP; Enzyme Activation; Female; GTP-Binding Protein alpha Subunits; Heterotrimeric GTP-Binding Proteins; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pertussis Toxin; Pyrrolidines; Receptors, Opioid; Virulence Factors, Bordetella

1999
Ligands for opioid and sigma-receptors improve cardiac electrical stability in rat models of post-infarction cardiosclerosis and stress.
    Life sciences, 1999, Volume: 65, Issue:1

    Topics: Animals; Anti-Arrhythmia Agents; beta-Endorphin; Disease Models, Animal; Dynorphins; Enkephalin, Leucine-2-Alanine; Heart; Immobilization; Ligands; Morphine; Myocardial Infarction; Myocardium; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Piperidines; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, delta; Stress, Physiological; Ventricular Fibrillation

1999
ASP147 in the third transmembrane helix of the rat mu opioid receptor forms ion-pairing with morphine and naltrexone.
    Life sciences, 1999, Volume: 65, Issue:2

    Topics: Animals; Aspartic Acid; Carboxylic Acids; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Ligands; Morphine; Mutagenesis, Site-Directed; Naltrexone; Protein Binding; Rats; Receptors, Opioid, mu

1999
Infusion of beta-FNA into the thalamus attenuates morphine-induced c-Fos induction in the rat caudate putamen.
    Brain research, 1999, Aug-14, Volume: 838, Issue:1-2

    Topics: Analgesics, Opioid; Animals; Caudate Nucleus; Infusions, Parenteral; Male; Morphine; Naltrexone; Narcotic Antagonists; Nerve Tissue Proteins; Proto-Oncogene Proteins c-fos; Putamen; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Thalamic Nuclei

1999
Discriminative stimulus effects of morphine in squirrel monkeys: stimulants, opioids, and stimulant-opioid combinations.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 290, Issue:3

    Topics: Amphetamine; Analgesics, Opioid; Anesthetics, Local; Animals; Anti-Anxiety Agents; Cocaine; Discrimination Learning; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Combinations; Fentanyl; Male; Morphine; Naltrexone; Narcotic Antagonists; Piperazines; Receptors, Opioid; Saimiri; Selective Serotonin Reuptake Inhibitors

1999
Spinal effect of a neuropeptide FF analogue on hyperalgesia and morphine-induced analgesia in mononeuropathic and diabetic rats.
    British journal of pharmacology, 1999, Volume: 127, Issue:6

    Topics: Analgesia; Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Diabetes Mellitus, Experimental; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Hyperalgesia; Injections, Spinal; Male; Morphine; Naltrexone; Narcotic Antagonists; Nervous System Diseases; Oligopeptides; Pain; Rats; Rats, Sprague-Dawley; Somatostatin; Time Factors; Vocalization, Animal

1999
Delta(2)-opioid receptor mediation of morphine-induced CCK release in the frontal cortex of the freely moving rat.
    Synapse (New York, N.Y.), 1999, Volume: 34, Issue:1

    Topics: Analgesics, Opioid; Animals; Cholecystokinin; Extracellular Space; Injections; Ligands; Male; Microdialysis; Morphine; Naltrexone; Narcotic Antagonists; Prefrontal Cortex; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Somatostatin

1999
Synthesis, opioid receptor binding, and biological activities of naltrexone-derived pyrido- and pyrimidomorphinans.
    Journal of medicinal chemistry, 1999, Sep-09, Volume: 42, Issue:18

    Topics: Analgesics; Animals; Binding, Competitive; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Ileum; Male; Mice; Mice, Inbred Strains; Morphinans; Morphine; Muscle Contraction; Naltrexone; Protein Binding; Rats; Receptors, Opioid; Vas Deferens

1999
Opioid-dependent effects of inescapable shock on escape behavior and conditioned fear responding are mediated by the dorsal raphe nucleus.
    Behavioural brain research, 1999, Volume: 99, Issue:2

    Topics: Analgesics, Opioid; Animals; Catheterization; Conditioning, Psychological; Electroshock; Escape Reaction; Fear; Helplessness, Learned; Male; Microinjections; Morphine; Naltrexone; Narcotic Antagonists; Opioid Peptides; Periaqueductal Gray; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Reinforcement Schedule; Serotonin

1999
Discriminative stimulus effects of nalbuphine in nontreated and morphine-treated pigeons.
    Pharmacology, biochemistry, and behavior, 1999, Volume: 64, Issue:2

    Topics: Analgesics, Opioid; Animals; Columbidae; Cues; Discrimination Learning; Discrimination, Psychological; Morphine; Nalbuphine; Naltrexone; Narcotic Antagonists; Reversal Learning

1999
Strain-dependent effects of MK-801 on passive avoidance behaviour in mice: interactions with morphine and immobilization stress.
    Psychopharmacology, 1999, Volume: 146, Issue:2

    Topics: Animals; Avoidance Learning; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Immobilization; Memory; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Species Specificity; Stress, Psychological

1999
Role of the dorsal raphe nucleus in morphine-induced immediate early gene expression in the rat striatum.
    Brain research, 1999, Sep-18, Volume: 842, Issue:1

    Topics: Analgesics, Opioid; Animals; Behavior, Animal; Gene Expression; Genes, fos; Genes, Immediate-Early; Immunohistochemistry; Male; Morphine; Naltrexone; Narcotic Antagonists; Neostriatum; Periaqueductal Gray; Proto-Oncogene Proteins c-jun; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Serotonin

1999
Enhancement of the contact hypersensitivity reaction by acute morphine administration at the elicitation phase.
    Clinical immunology (Orlando, Fla.), 1999, Volume: 93, Issue:2

    Topics: Animals; Croton Oil; Dermatitis, Contact; Dermatitis, Irritant; Dinitrofluorobenzene; Ear, External; Immunization; Injections, Subcutaneous; Interferon-gamma; Male; Morphine; Naltrexone; Rats; Rats, Inbred Lew

1999
Hyperalgesic response to noxious stimulation in genetically polydipsic mice.
    Brain research, 1999, Nov-06, Volume: 846, Issue:2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Drinking; Drinking Behavior; Hot Temperature; Hyperalgesia; Locomotion; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred Strains; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Nociceptors; Pain Measurement; Reaction Time; Water Deprivation

1999
Antagonism of heroin and morphine self-administration in rats by the morphine-6beta-glucuronide antagonist 3-O-methylnaltrexone.
    European journal of pharmacology, 1999, Oct-27, Volume: 383, Issue:2

    Topics: Animals; Conditioning, Operant; Dose-Response Relationship, Drug; Heroin; Injections, Subcutaneous; Male; Morphine; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Narcotics; Pain Measurement; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley; Rats, Wistar; Self Administration

1999
A comparative study of the effects of morphine in the dorsal periaqueductal gray and nucleus accumbens of rats submitted to the elevated plus-maze test.
    Experimental brain research, 1999, Volume: 129, Issue:2

    Topics: Analgesics, Opioid; Animals; Conditioning, Psychological; Fear; Male; Maze Learning; Microinjections; Morphine; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Periaqueductal Gray; Rats; Rats, Wistar; Receptors, Opioid, kappa; Receptors, Opioid, mu

1999
Neonatal naltrindole and handling differently affect morphine antinociception in male and female rats.
    Pharmacology, biochemistry, and behavior, 1999, Volume: 64, Issue:4

    Topics: Analgesics; Animals; Female; Handling, Psychological; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Rats; Rats, Wistar; Sex Characteristics; Stress, Physiological

1999
ATP-gated K(+) channel openers enhance opioid antinociception: indirect evidence for the release of endogenous opioid peptides.
    European journal of pharmacology, 1999, Dec-03, Volume: 385, Issue:2-3

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenosine Triphosphate; Analgesics; Animals; Cromakalim; Diazoxide; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Glyburide; Injections, Intraventricular; Ion Channel Gating; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Narcotic Antagonists; Nociceptors; Opioid Peptides; Pain; Potassium Channels; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin

1999
Role of corticotropin-releasing factor receptor-1 in opiate withdrawal.
    Journal of neurochemistry, 2000, Volume: 74, Issue:1

    Topics: Animals; Behavior, Animal; Male; Morphine; Naltrexone; Narcotic Antagonists; Protein Isoforms; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone; Substance Withdrawal Syndrome

2000
Discriminative stimulus effects of two doses of fentanyl in rats: pharmacological selectivity and effect of training dose on agonist and antagonist effects of mu opioids.
    Psychopharmacology, 2000, Volume: 148, Issue:2

    Topics: Analgesics, Opioid; Animals; Behavior, Animal; Central Nervous System Stimulants; Conditioning, Operant; Dextroamphetamine; Dose-Response Relationship, Drug; Fentanyl; Male; Methadone; Morphine; Nalbuphine; Nalorphine; Naltrexone; Narcotic Antagonists; Narcotics; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu

2000
Changes in analgesia-producing mechanism of repeated cold stress loading in mice.
    Pharmacology, biochemistry, and behavior, 2000, Volume: 65, Issue:2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Anti-Anxiety Agents; Anxiety; Cold Temperature; Diazepam; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Pain Threshold; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stress, Physiological

2000
Mechanisms of chloroquine-induced body-scratching behavior in rats: evidence of involvement of endogenous opioid peptides.
    Pharmacology, biochemistry, and behavior, 2000, Volume: 65, Issue:2

    Topics: Animals; Antimalarials; Chloroquine; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Opioid Peptides; Pruritus; Rats

2000
Enhanced analgesic potency and reduced tolerance of morphine in 129/SvEv mice: evidence for a deficiency in GM1 ganglioside-regulated excitatory opioid receptor functions.
    Brain research, 2000, Feb-21, Volume: 856, Issue:1-2

    Topics: Animals; Drug Tolerance; G(M1) Ganglioside; Male; Mice; Mice, Inbred Strains; Morphine; Naltrexone; Receptors, Opioid; Time Factors

2000
Modulatory effect of endogenous and exogenous opioids on the excitatory reflex pathway of the rat ileum.
    Neuropeptides, 2000, Volume: 34, Issue:1

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Ileum; In Vitro Techniques; Male; Morphine; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Narcotics; Peristalsis; Rats; Rats, Wistar; Receptors, Opioid; Somatostatin

2000
Acute delta-opioid receptor activation induces CREB phosphorylation in NG108-15 cells.
    European journal of pharmacology, 2000, Feb-25, Volume: 390, Issue:1-2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Analgesics, Opioid; Blotting, Western; Calmodulin; Cell Line; Cyclic AMP Response Element-Binding Protein; Enkephalin, D-Penicillamine (2,5)-; Enzyme Inhibitors; Humans; Isoquinolines; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Phosphorylation; Protein Kinase C; Protein Synthesis Inhibitors; Receptors, Opioid, delta; Time Factors

2000
An experimental itch model in monkeys: characterization of intrathecal morphine-induced scratching and antinociception.
    Anesthesiology, 2000, Volume: 92, Issue:3

    Topics: Analgesics, Opioid; Animals; Antipruritics; Dose-Response Relationship, Drug; Female; Hot Temperature; Injections, Spinal; Macaca mulatta; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Pruritus; Receptors, Opioid

2000
Short-acting NMDA receptor antagonist MRZ 2/576 produces prolonged suppression of morphine withdrawal in mice.
    Naunyn-Schmiedeberg's archives of pharmacology, 2000, Volume: 361, Issue:3

    Topics: Analysis of Variance; Animals; Dose-Response Relationship, Drug; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Phthalazines; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome; Tremor

2000
Activation of c-fos expression in hypothalamic nuclei by mu- and kappa-receptor agonists: correlation with catecholaminergic activity in the hypothalamic paraventricular nucleus.
    Endocrinology, 2000, Volume: 141, Issue:4

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Male; Methoxyhydroxyphenylglycol; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Norepinephrine; Paraventricular Hypothalamic Nucleus; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Suprachiasmatic Nucleus; Supraoptic Nucleus

2000
Acute opioid but not benzodiazepine dependence in rats responding for intracranial self-stimulation.
    Psychopharmacology, 2000, Volume: 148, Issue:3

    Topics: Animals; Benzodiazepines; Brain; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Male; Morphine; Naltrexone; Opioid-Related Disorders; Rats; Rats, Sprague-Dawley; Reinforcement Schedule; Self Stimulation; Substance-Related Disorders

2000
Morphine increases susceptibility to oral Salmonella typhimurium infection.
    The Journal of infectious diseases, 2000, Volume: 181, Issue:4

    Topics: Animals; Cytokines; Disease Susceptibility; Female; Germ-Free Life; Mice; Mice, Inbred C3H; Morphine; Mouth; Mouth Diseases; Naltrexone; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peyer's Patches; RNA, Messenger; Salmonella Infections, Animal; Salmonella typhimurium

2000
Inhibitory effect of intracerebroventricularly-administered [D-Arg(2), beta-Ala(4)]-dermorphin (1-4) on gastrointestinal transit.
    Peptides, 2000, Volume: 21, Issue:2

    Topics: Analgesics; Animals; Charcoal; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Female; Gastrointestinal Transit; Injections, Intraventricular; Mice; Mice, Inbred Strains; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides

2000
Daily mirfentanil induces (cross-) tolerance to the rate-decreasing effects of morphine and not mirfentanil.
    Behavioural pharmacology, 1999, Volume: 10, Issue:5

    Topics: Analgesics; Animals; Arousal; Columbidae; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Tolerance; Fentanyl; Ketamine; Morphine; Naltrexone

1999
Naltrexone and morphine alter the discrimination and plasma levels of ethanol.
    Behavioural pharmacology, 1999, Volume: 10, Issue:1

    Topics: Animals; Central Nervous System Depressants; Discrimination, Psychological; Dose-Response Relationship, Drug; Ethanol; Hypnotics and Sedatives; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Pentobarbital; Rats; Rats, Inbred Lew

1999
Acute exposure to saccharin reduces morphine analgesia in the the rat: evidence for involvement of N-methyl-D-aspartate and peripheral opioid receptors.
    Psychopharmacology, 2000, Volume: 149, Issue:1

    Topics: Analgesia; Analgesics, Opioid; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Quaternary Ammonium Compounds; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Saccharin; Sweetening Agents

2000
Effects of differential modulation of mu-, delta- and kappa-opioid systems on bicuculline-induced convulsions in the mouse.
    Brain research, 2000, Apr-17, Volume: 862, Issue:1-2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Bicuculline; Brain Chemistry; Convulsants; Enkephalin, D-Penicillamine (2,5)-; Epilepsy, Tonic-Clonic; Injections, Intraventricular; Injections, Subcutaneous; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Quinolines; Receptors, GABA-A; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Seizures; Synaptic Transmission

2000
Morphine tolerance in mice changes response of heroin from mu to delta opioid receptors.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 2000, Volume: 224, Issue:2

    Topics: Analgesics, Opioid; Animals; Drug Tolerance; Heroin; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Narcotics; Quaternary Ammonium Compounds; Receptors, Opioid, delta; Receptors, Opioid, mu

2000
Naloxone antagonizes GABA(A)/benzodiazepine receptor function in rat corticohippocampal synaptoneurosomes.
    Journal of neural transmission (Vienna, Austria : 1996), 2000, Volume: 107, Issue:3

    Topics: Amobarbital; Animals; Cerebral Cortex; Chlorine; GABA Modulators; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hippocampus; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Neurons; Radioisotopes; Rats; Rats, Sprague-Dawley; Synaptosomes

2000
Role of agonist-dependent receptor internalization in the regulation of mu opioid receptors.
    Neuroscience, 2000, Volume: 98, Issue:2

    Topics: Acetylcholine; Animals; Electric Stimulation; Endocytosis; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enteric Nervous System; Guinea Pigs; Ileum; Morphine; Naltrexone; Narcotic Antagonists; Neurons; Opioid Peptides; Organ Culture Techniques; Receptors, Opioid, mu

2000
Acute dependence on, but not tolerance to, heroin and morphine as measured by respiratory effects in rhesus monkeys.
    European journal of pharmacology, 2000, Jun-09, Volume: 398, Issue:1

    Topics: Analgesics, Opioid; Animals; Carbon Dioxide; Dose-Response Relationship, Drug; Drug Tolerance; Heroin; Heroin Dependence; Macaca mulatta; Morphine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Respiration; Time Factors

2000
The effect of nimodipine on opioid antagonist-induced upregulation and supersensitivity.
    Pharmacology, biochemistry, and behavior, 2000, Volume: 66, Issue:2

    Topics: Animals; Calcium Channel Blockers; Dose-Response Relationship, Drug; Drug Tolerance; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Nimodipine; Receptors, Opioid, mu; Up-Regulation

2000
Opiate withdrawal in the fetal rat: a behavioral profile.
    Pharmacology, biochemistry, and behavior, 2000, Volume: 66, Issue:2

    Topics: Animals; Behavior, Animal; Disease Models, Animal; Female; Fetus; Humans; Maternal-Fetal Exchange; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Pregnancy; Rats; Substance Withdrawal Syndrome

2000
Upregulation of galanin binding sites and GalR1 mRNA levels in the mouse locus coeruleus following chronic morphine treatments and precipitated morphine withdrawal.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2000, Volume: 23, Issue:2

    Topics: Animals; Autoradiography; Behavior, Animal; Drug Administration Schedule; Female; Galanin; In Situ Hybridization; Iodine Radioisotopes; Locus Coeruleus; Mice; Mice, Inbred C57BL; Morphine; Naltrexone; Nucleus Accumbens; Receptors, Galanin; Receptors, Neuropeptide; RNA, Messenger; Substance Withdrawal Syndrome; Up-Regulation; Ventral Tegmental Area

2000
Further characterization of the discriminative stimulus effects of spiradoline.
    Pharmacology, biochemistry, and behavior, 2000, Volume: 66, Issue:3

    Topics: Analgesics, Non-Narcotic; Animals; Benzeneacetamides; Discrimination Learning; Drug Interactions; Male; Morphine; Naltrexone; Narcotic Antagonists; Nicotinic Antagonists; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Tetrahydronaphthalenes

2000
Calmodulin regulation of basal and agonist-stimulated G protein coupling by the mu-opioid receptor (OP(3)) in morphine-pretreated cell.
    Journal of neurochemistry, 2000, Volume: 75, Issue:2

    Topics: Amino Acid Substitution; Animals; Calmodulin; Cell Line; Cell Membrane; Chickens; Egtazic Acid; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Kidney; Kinetics; Morphine; Mutagenesis, Site-Directed; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu; Recombinant Proteins; Transfection

2000
Behavioral activation induced by D(2)-like receptor stimulation during opiate withdrawal.
    The Journal of pharmacology and experimental therapeutics, 2000, Volume: 294, Issue:2

    Topics: Analgesics, Opioid; Animals; Apomorphine; Behavior, Animal; Dopamine Agonists; Dopamine Antagonists; Drug Synergism; Locomotion; Male; Morphine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Stereotyped Behavior; Substance Withdrawal Syndrome

2000
[Regulation of the central opioidergic nervous system on the emotional state of anxiety and its possible mechanisms].
    Sheng li ke xue jin zhan [Progress in physiology], 1997, Volume: 28, Issue:1

    Topics: Animals; Anxiety; Brain; Morphine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Rats; Serotonin; Substance Withdrawal Syndrome

1997
Morphine stimulates mesangial cell TNF-alpha and nitrite production.
    Inflammation, 2000, Volume: 24, Issue:5

    Topics: Animals; Antibodies, Monoclonal; Cell Line, Transformed; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Gene Expression Regulation; Glomerular Mesangium; Glomerulosclerosis, Focal Segmental; Heroin Dependence; HIV Envelope Protein gp120; HIV Infections; Lipopolysaccharides; Macrophages; Mice; Morphine; Muscle, Smooth, Vascular; Naloxone; Naltrexone; Narcotic Antagonists; NG-Nitroarginine Methyl Ester; Nitrites; Tumor Necrosis Factor-alpha

2000
Naltrexone-precipitated morphine withdrawal in infant rat is attenuated by acute administration of NOS inhibitors but not NMDA receptor antagonists.
    Psychopharmacology, 2000, Volume: 150, Issue:3

    Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Animals, Newborn; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Humans; Indazoles; Infant, Newborn; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Neonatal Abstinence Syndrome; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Rats; Rats, Long-Evans; Receptors, N-Methyl-D-Aspartate

2000
beta-Funaltrexamine inactivates ORL1 receptors in BE(2)-C human neuroblastoma cells.
    European journal of pharmacology, 2000, Aug-18, Volume: 402, Issue:1-2

    Topics: Brain Neoplasms; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Humans; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Neuroblastoma; Nociceptin; Nociceptin Receptor; Opioid Peptides; Receptors, Opioid; Receptors, Opioid, mu; Tumor Cells, Cultured

2000
Expression of fos-related antigens in the nucleus accumbens during opiate withdrawal and their attenuation by a D2 dopamine receptor agonist.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2000, Volume: 23, Issue:3

    Topics: Animals; Apomorphine; Behavior, Animal; Dopamine Agonists; Dopamine Antagonists; Immunohistochemistry; Lithium Chloride; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Nucleus Accumbens; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Substance Withdrawal Syndrome

2000
Methocinnamox is a potent, long-lasting, and selective antagonist of morphine-mediated antinociception in the mouse: comparison with clocinnamox, beta-funaltrexamine, and beta-chlornaltrexamine.
    The Journal of pharmacology and experimental therapeutics, 2000, Volume: 294, Issue:3

    Topics: Analgesics, Opioid; Animals; Binding, Competitive; Cerebral Cortex; Cinnamates; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Male; Mice; Morphine; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Pain Measurement; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu

2000
Selectivity of mu-opioid receptor determined by interfacial residues near third extracellular loop.
    European journal of pharmacology, 2000, Sep-01, Volume: 403, Issue:1-2

    Topics: Amino Acid Substitution; Animals; Benzamides; Benzomorphans; Binding Sites; Binding, Competitive; COS Cells; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Fentanyl; Guanosine 5'-O-(3-Thiotriphosphate); Ligands; Morphine; Mutation; Naloxone; Naltrexone; Narcotic Antagonists; Peptides; Piperazines; Protein Conformation; Radioligand Assay; Rats; Receptors, Opioid, mu; Signal Transduction; Sulfur Radioisotopes

2000
Assessment of SNC 80 and naltrindole within a conditioned taste aversion design.
    Pharmacology, biochemistry, and behavior, 2000, Volume: 66, Issue:4

    Topics: Animals; Avoidance Learning; Benzamides; Conditioning, Operant; Dose-Response Relationship, Drug; Female; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Piperazines; Rats; Rats, Long-Evans; Receptors, Opioid, delta; Saccharin; Sweetening Agents; Taste

2000
Morphine discriminative control is mediated by the mu opioid receptor: assessment of delta opioid substitution and antagonism.
    Pharmacology, biochemistry, and behavior, 2000, Volume: 66, Issue:4

    Topics: Animals; Benzamides; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Female; Generalization, Response; Methadone; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Piperazines; Rats; Rats, Long-Evans; Receptors, Opioid, delta; Receptors, Opioid, mu

2000
A pharmacological analysis of the substrates underlying conditioned feeding induced by repeated opioid stimulation of the nucleus accumbens.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2000, Volume: 23, Issue:4

    Topics: Analgesics, Opioid; Animals; Conditioning, Psychological; Dopamine Antagonists; Eating; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Nucleus Accumbens; Rats; Rats, Sprague-Dawley

2000
Inhibitory effects of morphine on some inflammation-related parameters in the goldfish Carassius auratus L.
    Fish & shellfish immunology, 2000, Volume: 10, Issue:6

    Topics: Analgesics, Opioid; Animals; Chemotaxis; Coloring Agents; Evans Blue; Exudates and Transudates; Fish Diseases; Goldfish; Injections, Intraperitoneal; Leukocyte Count; Morphine; Naltrexone; Narcotic Antagonists; Peritonitis; Thioglycolates

2000
Endomorphin-1 induces antinociception without immunomodulatory effects in the rat.
    Psychopharmacology, 2000, Volume: 151, Issue:4

    Topics: Analgesics, Opioid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Immune System; Injections, Intraventricular; Interferon-gamma; Lymphocyte Activation; Male; Morphine; Naltrexone; Oligopeptides; Rats; Rats, Inbred Lew

2000
Morphine enhances interleukin-12 and the production of other pro-inflammatory cytokines in mouse peritoneal macrophages.
    Journal of leukocyte biology, 2000, Volume: 68, Issue:5

    Topics: Adjuvants, Immunologic; Analgesics, Opioid; Animals; Corynebacterium; Delayed-Action Preparations; Female; Inflammation Mediators; Interferon-gamma; Interleukin-10; Interleukin-12; Lipopolysaccharides; Macrophages, Peritoneal; Mice; Mice, Inbred C3H; Morphine; Naltrexone; Narcotic Antagonists; RNA, Messenger; Stimulation, Chemical; Tumor Necrosis Factor-alpha

2000
N-Cyclohexylethyl-N-noroxymorphindole: a mu-opioid preferring analogue of naltrindole.
    Bioorganic & medicinal chemistry letters, 2000, Nov-06, Volume: 10, Issue:21

    Topics: Analgesics; Animals; Mice; Molecular Structure; Morphine; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Pain Measurement; Receptors, Opioid, mu

2000
Spinal kappa-opioid system plays an important role in suppressing morphine withdrawal syndrome in the rat.
    Neuroscience letters, 2000, Dec-01, Volume: 295, Issue:1-2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Male; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid, kappa; Substance Withdrawal Syndrome

2000
Dose- and time-dependent bimodal effects of kappa-opioid agonists on locomotor activity in mice.
    The Journal of pharmacology and experimental therapeutics, 2000, Volume: 295, Issue:3

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetamides; Animals; Benzomorphans; Dose-Response Relationship, Drug; Isothiocyanates; Male; Mice; Morphine; Motor Activity; Naloxone; Naltrexone; Receptors, Opioid, kappa; Time Factors

2000
Inhibition of morphine tolerance development by a substance P-opioid peptide chimera.
    The Journal of pharmacology and experimental therapeutics, 2000, Volume: 295, Issue:3

    Topics: Analgesics, Opioid; Animals; Drug Tolerance; Indoles; Isoindoles; Male; Morphine; Naltrexone; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Structure-Activity Relationship; Substance P

2000
Morphine-6 beta-glucuronide has a higher efficacy than morphine as a mu-opioid receptor agonist in the rat locus coeruleus.
    British journal of pharmacology, 2000, Volume: 131, Issue:7

    Topics: Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Locus Coeruleus; Male; Membrane Potentials; Morphine; Morphine Derivatives; Naltrexone; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu

2000
Morphine inhibits human microglial cell production of, and migration towards, RANTES.
    Journal of psychopharmacology (Oxford, England), 2000, Volume: 14, Issue:3

    Topics: Brain; Calcium; Cells, Cultured; Chemokine CCL5; Chemotaxis; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Fetus; Humans; Interleukin-1; Lipopolysaccharides; Microglia; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Recombinant Proteins

2000
Testosterone is required for corticosteroid-binding globulin upregulation by morphine to be fully manifested.
    Pharmacology, biochemistry, and behavior, 2000, Volume: 67, Issue:1

    Topics: Animals; Male; Morphine; Naltrexone; Orchiectomy; Rats; Rats, Sprague-Dawley; Testosterone; Transcortin; Up-Regulation

2000
The role of opioid receptors in morphine withdrawal in the infant rat.
    Brain research. Developmental brain research, 2000, Nov-30, Volume: 124, Issue:1-2

    Topics: Animals; Animals, Newborn; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Long-Evans; Receptors, Opioid; Receptors, Opioid, mu; Somatostatin; Substance Withdrawal Syndrome

2000
Mapping of c-fos gene expression in the brain during morphine dependence and precipitated withdrawal, and phenotypic identification of the striatal neurons involved.
    The European journal of neuroscience, 2000, Volume: 12, Issue:12

    Topics: Animals; Brain; Corpus Striatum; Drug Implants; Gene Expression Regulation; Genes, fos; Male; Morphine; Morphine Dependence; Naltrexone; Neurons; Organ Specificity; Phenotype; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; RNA, Messenger; Substance Withdrawal Syndrome; Transcription, Genetic

2000
Acute thermal hyperalgesia elicited by low-dose morphine in normal mice is blocked by ultra-low-dose naltrexone, unmasking potent opioid analgesia.
    Brain research, 2001, Jan-05, Volume: 888, Issue:1

    Topics: Acute Disease; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Etorphine; Hot Temperature; Hyperalgesia; Male; Mice; Morphine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Pain Threshold; Receptors, Opioid

2001
Intestinal inflammation enhances the inhibitory effects of opioids on intestinal permeability in mice.
    The Journal of pharmacology and experimental therapeutics, 2001, Volume: 296, Issue:2

    Topics: Analgesics, Opioid; Animals; Croton Oil; Dose-Response Relationship, Drug; Enteritis; Gastrointestinal Motility; Injections, Intraventricular; Intestinal Absorption; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Permeability; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, sigma

2001
Parametric evaluation of the development of sensitization to the effects of morphine on locomotor activity.
    Drug and alcohol dependence, 2001, Mar-01, Volume: 62, Issue:1

    Topics: Animals; Area Under Curve; Dose-Response Relationship, Drug; Drug Tolerance; Male; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Sprague-Dawley

2001
Injections of an opioid antagonist into the locus coeruleus and periaqueductal gray but not the amygdala precipitates morphine withdrawal in the 7-day-old rat.
    Synapse (New York, N.Y.), 2001, Volume: 39, Issue:2

    Topics: Age Factors; Amygdala; Animals; Animals, Newborn; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Locus Coeruleus; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Neural Pathways; Opioid-Related Disorders; Periaqueductal Gray; Quaternary Ammonium Compounds; Rats; Rats, Long-Evans; Substance Withdrawal Syndrome

2001
Place aversion induced by blockade of mu or activation of kappa opioid receptors in the dorsal periaqueductal gray matter.
    Behavioural pharmacology, 2000, Volume: 11, Issue:7-8

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analysis of Variance; Animals; Behavior, Animal; Conditioning, Operant; Dose-Response Relationship, Drug; Male; Morphine; Naltrexone; Periaqueductal Gray; Rats; Rats, Wistar; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin

2000
Activity of mu- and delta-opioid agonists in vas deferens from mice deficient in MOR gene.
    British journal of pharmacology, 2001, Volume: 132, Issue:7

    Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Female; Genotype; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Mutant Strains; Morphine; Muscle Contraction; Naltrexone; Narcotic Antagonists; Oligopeptides; Receptors, Opioid, delta; Receptors, Opioid, mu; Vas Deferens

2001
The novel kappa-opioid receptor agonist TRK-820 suppresses the rewarding and locomotor-enhancing effects of morphine in mice.
    Life sciences, 2001, Mar-02, Volume: 68, Issue:15

    Topics: Animals; Dose-Response Relationship, Drug; Male; Mice; Morphinans; Morphine; Motor Activity; Naltrexone; Narcotics; Receptors, Opioid, kappa; Reward; Spiro Compounds

2001
Involvement of substance P and central opioid receptors in morphine modulation of the CHS response.
    Journal of neuroimmunology, 2001, Apr-02, Volume: 115, Issue:1-2

    Topics: Androstanes; Animals; Benzimidazoles; Dermatitis, Contact; Dinitrofluorobenzene; Disease Models, Animal; Drug Administration Routes; Male; Morphine; Naltrexone; Narcotic Antagonists; Neurokinin-1 Receptor Antagonists; Quaternary Ammonium Compounds; Rats; Rats, Inbred Lew; Receptors, Opioid; Specific Pathogen-Free Organisms; Substance P

2001
Inverse agonist action of Leu-enkephalin at delta(2)-opioid receptors mediates spinal antianalgesia.
    The Journal of pharmacology and experimental therapeutics, 2001, Volume: 297, Issue:2

    Topics: Analgesics, Opioid; Animals; Benzylidene Compounds; Cholecystokinin; Drug Tolerance; Enkephalin, Leucine; Excitatory Amino Acid Agonists; Male; Mice; Morphine; N-Methylaspartate; Naltrexone; Narcotic Antagonists; Pain Measurement; Receptors, Opioid, delta; Spinal Cord

2001
Beta-endorphin-induced feeding: pharmacological characterization using selective opioid antagonists and antisense probes in rats.
    The Journal of pharmacology and experimental therapeutics, 2001, Volume: 297, Issue:2

    Topics: Analgesics, Opioid; Animals; Antisense Elements (Genetics); beta-Endorphin; Cloning, Molecular; Dose-Response Relationship, Drug; Eating; Exons; Feeding Behavior; Male; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta

2001
Inhibition of morphine withdrawal by the NMDA receptor antagonist MK-801 in rat is age-dependent.
    Synapse (New York, N.Y.), 2001, Jun-15, Volume: 40, Issue:4

    Topics: Age Factors; Animals; Body Temperature; Body Weight; Central Nervous System; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Administration Routes; Excitatory Amino Acid Antagonists; Male; Morphine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Long-Evans; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome

2001
TRK-820, a selective kappa-opioid agonist, produces potent antinociception in cynomolgus monkeys.
    Japanese journal of pharmacology, 2001, Volume: 85, Issue:3

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Behavior, Animal; Macaca fascicularis; Morphinans; Morphine; Naloxone; Naltrexone; Pain Measurement; Pentazocine; Pentobarbital; Receptors, Opioid, kappa; Spiro Compounds

2001
Pharmacological characterization of the dermorphin analog [Dmt(1)]DALDA, a highly potent and selective mu-opioid peptide.
    European journal of pharmacology, 2001, May-04, Volume: 419, Issue:1

    Topics: Analgesics; Animals; Drug Tolerance; Humans; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Oligodeoxyribonucleotides, Antisense; Oligopeptides; Opioid Peptides; Pain Measurement; Receptors, Opioid, mu; Time Factors

2001
Acute opioid pretreatment potentiates naltrexone-induced drinking suppression in water-deprived rats.
    The Journal of pharmacology and experimental therapeutics, 2001, Volume: 298, Issue:1

    Topics: Analgesics, Opioid; Animals; Area Under Curve; Discrimination, Psychological; Dose-Response Relationship, Drug; Drinking; Fentanyl; Male; Meperidine; Morphine; Naltrexone; Narcotic Antagonists; Pain Measurement; Rats; Rats, Sprague-Dawley; Water Deprivation

2001
Chronic exposure to mu-opioid agonists produces constitutive activation of mu-opioid receptors in direct proportion to the efficacy of the agonist used for pretreatment.
    Molecular pharmacology, 2001, Volume: 60, Issue:1

    Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Analgesics, Opioid; Animals; Binding Sites; Cells, Cultured; Cyclic AMP; Down-Regulation; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Receptors, Opioid, mu; Sulfur Radioisotopes; Transfection; Virulence Factors, Bordetella

2001
Inverse agonists and neutral antagonists at mu opioid receptor (MOR): possible role of basal receptor signaling in narcotic dependence.
    Journal of neurochemistry, 2001, Volume: 77, Issue:6

    Topics: Analgesics, Opioid; Animals; Benzylidene Compounds; Cell Line; Cell Membrane; Cyclic AMP; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Kidney; Magnesium; Male; Mice; Mice, Inbred ICR; Morphine; Morphine Dependence; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Receptors, Opioid, mu; Signal Transduction; Substance Withdrawal Syndrome; Sulfur Radioisotopes; Transfection; Tritium

2001
Single nucleotide polymorphisms in the human mu opioid receptor gene alter basal G protein coupling and calmodulin binding.
    The Journal of biological chemistry, 2001, Sep-14, Volume: 276, Issue:37

    Topics: Calmodulin; Cells, Cultured; Cyclic AMP; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Magnesium; Morphine; Naltrexone; Polymorphism, Genetic; Receptors, Opioid, mu

2001
SoRI 9409, a non-peptide opioid mu receptor agonist/delta receptor antagonist, fails to stimulate [35S]-GTP-gamma-S binding at cloned opioid receptors.
    Brain research bulletin, 2001, Jul-01, Volume: 55, Issue:4

    Topics: Analgesics; Analgesics, Opioid; Animals; Benzamides; Benzeneacetamides; Binding, Competitive; CHO Cells; Cloning, Molecular; Cricetinae; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Iodine Radioisotopes; Morphine; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Piperazines; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sulfur Radioisotopes; Tritium

2001
Critical role of mast cells in morphine-mediated impairment of zymosan-induced peritonitis in mice.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2001, Volume: 50, Issue:8

    Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents; Bone Marrow Cells; Capillary Permeability; Cell Count; Chemotaxis, Leukocyte; Histamine; Male; Mast Cells; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; Morphine; Naltrexone; Narcotic Antagonists; Peritonitis; Zymosan

2001
Parallel synthesis and biological activity of a new class of high affinity and selective delta-opioid ligand.
    Bioorganic & medicinal chemistry, 2001, Volume: 9, Issue:10

    Topics: Amides; Analgesics, Opioid; Animals; Benzamides; Brain; Catalysis; Combinatorial Chemistry Techniques; Guinea Pigs; Humans; Inhibitory Concentration 50; Isoquinolines; Ligands; Male; Maleimides; Membrane Proteins; Mice; Mice, Inbred ICR; Molecular Structure; Morphine; Naltrexone; Nerve Tissue Proteins; Pain Measurement; Phthalimides; Piperazines; Quinolines; Rats; Rats, Wistar; Receptors, Opioid, delta; Structure-Activity Relationship; Succinimides; Sulfonamides

2001
Kappa-opioid receptors on lymphocytes of a human lymphocytic cell line: morphine-induced up-regulation as evidenced by competitive RT-PCR and indirect immunofluorescence.
    International immunopharmacology, 2001, Volume: 1, Issue:9-10

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Cell Line; Fluorescent Antibody Technique, Indirect; Humans; Lymphocytes; Morphine; Naltrexone; Narcotic Antagonists; Receptors, Opioid, kappa; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Up-Regulation

2001
Opioid system diversity in developing neurons, astroglia, and oligodendroglia in the subventricular zone and striatum: impact on gliogenesis in vivo.
    Glia, 2001, Volume: 36, Issue:1

    Topics: Aging; Amino Acid Transport System X-AG; Animals; Animals, Newborn; Antigens, Differentiation; Antigens, Surface; Astrocytes; Bromodeoxyuridine; Calcium-Binding Proteins; Cell Differentiation; Cell Division; Glial Fibrillary Acidic Protein; Immunohistochemistry; Lateral Ventricles; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Neostriatum; Nerve Growth Factors; Neurons; Oligodendroglia; Opioid Peptides; Receptors, Opioid; S100 Calcium Binding Protein beta Subunit; S100 Proteins

2001
Effectiveness of repeated administration of a new oral naltrexone controlled-release system on morphine analgesia.
    The Journal of pharmacy and pharmacology, 2001, Volume: 53, Issue:9

    Topics: Administration, Oral; Animals; Delayed-Action Preparations; Drug Administration Schedule; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Pain

2001
Administration of mu-, kappa- or delta2-receptor agonists via osmotic minipumps suppresses murine splenic antibody responses.
    International immunopharmacology, 2001, Volume: 1, Issue:11

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Antibody Formation; Depression, Chemical; Dose-Response Relationship, Drug; Female; Immunosuppressive Agents; Infusion Pumps; Mice; Mice, Inbred C3H; Morphine; Naltrexone; Neuroimmunomodulation; Oligopeptides; Osmosis; Peptide Fragments; Peptides; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin; Spleen

2001
Cholera toxin-B subunit blocks excitatory opioid receptor-mediated hyperalgesic effects in mice, thereby unmasking potent opioid analgesia and attenuating opioid tolerance/dependence.
    Brain research, 2001, Nov-16, Volume: 919, Issue:1

    Topics: Adjuvants, Immunologic; Administration, Oral; Analgesics, Opioid; Animals; Cells, Cultured; Cholera Toxin; Drug Administration Schedule; Drug Tolerance; Hot Temperature; Hyperalgesia; Injections, Subcutaneous; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Pain Measurement; Receptors, Opioid; Substance Withdrawal Syndrome

2001
Interaction of morphine and naltrexone on oral ethanol self-administration in rhesus monkeys.
    Behavioural pharmacology, 2001, Volume: 12, Issue:5

    Topics: Alcohol Drinking; Analgesics, Opioid; Animals; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Interactions; Macaca mulatta; Male; Morphine; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu; Reinforcement, Psychology

2001
Effect of opioids on oral Salmonella infection and immune function.
    Advances in experimental medicine and biology, 2001, Volume: 493

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Drug Implants; Female; Immunosuppressive Agents; Infusion Pumps, Implantable; Mice; Mice, Inbred C3H; Morphine; Mouth Diseases; Naltrexone; Narcotic Antagonists; Narcotics; Oligopeptides; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Salmonella Infections, Animal; Salmonella typhimurium

2001
Morphine upregulates kappa-opioid receptors of human lymphocytes.
    Advances in experimental medicine and biology, 2001, Volume: 493

    Topics: Animals; Cell Line; Humans; Hybrid Cells; Immunosuppressive Agents; Lymphocytes; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, kappa; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Up-Regulation

2001
Naltrexone microspheres: in vitro release and effect on morphine analgesia in mice.
    Acta pharmacologica Sinica, 2001, Volume: 22, Issue:6

    Topics: Analgesia; Animals; Delayed-Action Preparations; Female; Lactic Acid; Mice; Microspheres; Morphine; Naltrexone; Narcotic Antagonists; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers

2001
Rapid elevation of plasma interleukin-6 by morphine is dependent on autonomic stimulation of adrenal gland.
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 300, Issue:1

    Topics: Adrenal Glands; Adrenal Medulla; Adrenalectomy; Animals; Autonomic Nervous System; Chlorisondamine; Corticosterone; Dose-Response Relationship, Drug; Ganglionic Blockers; Injections, Intraventricular; Interleukin-6; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Sprague-Dawley; Stimulation, Chemical

2002
Methadone enhances human immunodeficiency virus infection of human immune cells.
    The Journal of infectious diseases, 2002, Jan-01, Volume: 185, Issue:1

    Topics: Adult; Drug Interactions; Fetus; HIV Infections; Humans; Immunosuppressive Agents; Macrophages; Methadone; Microglia; Middle Aged; Monocytes; Morphine; Naltrexone; Narcotics; Receptors, CCR5

2002
Central discriminative effects of morphine in rats: training via intracerebroventricular administration.
    Brain research bulletin, 2001, Volume: 56, Issue:6

    Topics: Animals; Brain; Discrimination Learning; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Interactions; Enzyme Inhibitors; Injections, Intraventricular; Injections, Subcutaneous; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Opioid Peptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid

2001
Comparison of the peripheral and central effects of the opioid agonists loperamide and morphine in the formalin test in rats.
    Neuropharmacology, 2002, Volume: 42, Issue:2

    Topics: Analgesics, Opioid; Animals; Antidiarrheals; Cisterna Magna; Dose-Response Relationship, Drug; Formaldehyde; Injections; Injections, Subcutaneous; Loperamide; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu

2002
Effect of precipitated morphine withdrawal on post-translational processing of prothyrotropin releasing hormone (proTRH) in the ventrolateral column of the midbrain periaqueductal gray.
    Journal of neurochemistry, 2002, Volume: 80, Issue:5

    Topics: Animals; Blotting, Western; Brain Chemistry; Electrophoresis, Polyacrylamide Gel; Hypothalamus; Immunohistochemistry; Male; Median Eminence; Morphine; Naltrexone; Paraventricular Hypothalamic Nucleus; Peptide Fragments; Periaqueductal Gray; Proprotein Convertase 2; Protein Precursors; Protein Processing, Post-Translational; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Subtilisins; Thyrotropin-Releasing Hormone; Up-Regulation

2002
Regional and cellular mapping of cAMP response element-mediated transcription during naltrexone-precipitated morphine withdrawal.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002, May-01, Volume: 22, Issue:9

    Topics: Amygdala; Animals; beta-Galactosidase; Corticotropin-Releasing Hormone; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Female; Genes, Reporter; Locus Coeruleus; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Morphine; Naltrexone; Nucleus Accumbens; Raphe Nuclei; Receptors, Opioid, mu; Response Elements; Substance Withdrawal Syndrome; Transcription, Genetic; Tyrosine 3-Monooxygenase; Up-Regulation; Ventral Tegmental Area

2002
Motivational effects mu- and kappa-opioid agonists following acute and chronic restraint stress: involvement of dopamine D(1) and D(2) receptors.
    Behavioural brain research, 2002, May-14, Volume: 132, Issue:2

    Topics: Acute Disease; Animals; Behavior, Animal; Benzomorphans; Chronic Disease; Conditioning, Operant; Injections, Intraventricular; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stress, Psychological

2002
Delta opioid inhibition of light-induced phase advances in hamster circadian activity rhythms.
    Brain research, 2002, May-24, Volume: 937, Issue:1-2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzamides; Biological Clocks; Circadian Rhythm; Cricetinae; Enkephalins; Light; Male; Mesocricetus; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Nerve Tissue Proteins; Opioid Peptides; Piperazines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Suprachiasmatic Nucleus

2002
Antagonism of the antinociceptive and discriminative stimulus effects of heroin and morphine by 3-methoxynaltrexone and naltrexone in rhesus monkeys.
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 302, Issue:1

    Topics: Analgesics; Analgesics, Opioid; Animals; Cues; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Heroin; Hot Temperature; Kinetics; Macaca mulatta; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain Measurement; Substance-Related Disorders

2002
Differential morphine tolerance development in the modulation of macrophage cytokine production in mice.
    Journal of leukocyte biology, 2002, Volume: 72, Issue:1

    Topics: Analgesics, Opioid; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Drug Tolerance; Interleukin-10; Interleukin-12; Kinetics; Macrophages; Male; Mice; Mice, Inbred BALB C; Morphine; Naltrexone; Narcotic Antagonists

2002
Serum naltrexone and 6-beta-naltrexol levels from naltrexone implants can block very large amounts of heroin: a report of two cases.
    Addiction biology, 2002, Volume: 7, Issue:3

    Topics: Adult; Delayed-Action Preparations; Dose-Response Relationship, Drug; Drug Implants; Half-Life; Heroin; Heroin Dependence; Humans; Male; Morphine; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Patient Dropouts

2002
Possible involvement of mu1-opioid receptors in the fentanyl- or morphine-induced antinociception at supraspinal and spinal sites.
    Life sciences, 2002, Apr-05, Volume: 70, Issue:20

    Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Fentanyl; Injections, Intraventricular; Injections, Spinal; Injections, Subcutaneous; Male; Mice; Mice, Inbred C57BL; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Receptors, Opioid, mu; Spinal Cord

2002
Effects of opioid antagonists on unconditioned and conditioned hyperactivity to morphine.
    Pharmacology, biochemistry, and behavior, 2002, Volume: 73, Issue:3

    Topics: Analgesics, Opioid; Animals; Conditioning, Operant; Dose-Response Relationship, Drug; Hyperkinesis; Male; Morphine; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu

2002
Chronic agonist treatment converts antagonists into inverse agonists at delta-opioid receptors.
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 302, Issue:3

    Topics: Adenylyl Cyclases; Analgesics, Opioid; Animals; Cell Line; Cell Membrane; Drug Tolerance; Enkephalin, D-Penicillamine (2,5)-; Guanosine 5'-O-(3-Thiotriphosphate); Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Receptors, Opioid, delta; Receptors, Opioid, mu

2002
Influence of acute or repeated restraint stress on morphine-induced locomotion: involvement of dopamine, opioid and glutamate receptors.
    Behavioural brain research, 2002, Aug-21, Volume: 134, Issue:1-2

    Topics: Acute Disease; Animals; Benzazepines; Chronic Disease; Dizocilpine Maleate; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Excitatory Amino Acid Antagonists; Male; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Wistar; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Restraint, Physical; Stress, Psychological; Sulpiride

2002
Lack of the nociceptin receptor does not affect acute or chronic nociception in mice.
    Peptides, 2002, Volume: 23, Issue:9

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Female; Male; Mice; Mice, Knockout; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptin; Nociceptin Receptor; Oligopeptides; Opioid Peptides; Pain; Receptors, Opioid; Time Factors; Vas Deferens

2002
Morphine regulates gene expression of alpha- and beta-chemokines and their receptors on astroglial cells via the opioid mu receptor.
    Journal of immunology (Baltimore, Md. : 1950), 2002, Oct-01, Volume: 169, Issue:7

    Topics: Adjuvants, Immunologic; Astrocytes; Astrocytoma; Cells, Cultured; Chemokine CCL4; Chemokines, CC; Chemokines, CXC; Down-Regulation; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Humans; Immunophenotyping; Interleukin-8; Macrophage Inflammatory Proteins; Morphine; Naltrexone; Receptors, CCR3; Receptors, CCR5; Receptors, Chemokine; Receptors, Interleukin-8B; Receptors, Opioid, mu; Tumor Cells, Cultured; Up-Regulation

2002
Pharmacology of opioid inhibition to noxious uterine cervical distension.
    Anesthesiology, 2002, Volume: 97, Issue:4

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Cervix Uteri; Dose-Response Relationship, Drug; Electromyography; Female; Hemodynamics; Morphine; Naltrexone; Narcotic Antagonists; Ovariectomy; Pain Threshold; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Uterus

2002
Kappa opioid antagonist effects of the novel kappa antagonist 5'-guanidinonaltrindole (GNTI) in an assay of schedule-controlled behavior in rhesus monkeys.
    Psychopharmacology, 2002, Volume: 163, Issue:3-4

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Non-Narcotic; Animals; Benzamides; Benzeneacetamides; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Interactions; Female; Guanidines; Macaca mulatta; Male; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Piperazines; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Reinforcement Schedule; Time Factors

2002
Focal kappa-opioid receptor-mediated dependence and withdrawal in the nucleus paragigantocellularis.
    Pharmacology, biochemistry, and behavior, 2002, Volume: 74, Issue:1

    Topics: Animals; Basal Ganglia; Butorphanol; Diffusion; Electric Stimulation; Male; Microinjections; Morphine; Morphine Dependence; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Stereotaxic Techniques; Stereotyped Behavior; Substance Withdrawal Syndrome

2002
GABAergic and glutamatergic afferents in the dorsal raphe nucleus mediate morphine-induced increases in serotonin efflux in the rat central nervous system.
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 303, Issue:2

    Topics: Analgesics, Opioid; Animals; Central Nervous System; Excitatory Amino Acid Agonists; GABA Agonists; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Glutamic Acid; Male; Microdialysis; Microinjections; Morphine; Muscimol; Naltrexone; Narcotic Antagonists; Neurons, Afferent; Nucleus Accumbens; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Serotonin

2002
Morphine enhances HIV infection of human blood mononuclear phagocytes through modulation of beta-chemokines and CCR5 receptor.
    Journal of investigative medicine : the official publication of the American Federation for Clinical Research, 2002, Volume: 50, Issue:6

    Topics: Chemokines, CC; DNA Replication; DNA, Viral; Dose-Response Relationship, Drug; HIV; Humans; Macrophages; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Phagocytosis; Receptors, CCR5; Species Specificity; Up-Regulation; Virus Replication

2002
Potency differences for D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 as an antagonist of peptide and alkaloid micro-agonists in an antinociception assay.
    The Journal of pharmacology and experimental therapeutics, 2003, Volume: 304, Issue:1

    Topics: Alkaloids; Analgesics, Opioid; Animals; Binding, Competitive; Buprenorphine; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Etorphine; Injections, Intraventricular; Injections, Subcutaneous; Male; Morphine; Naltrexone; Narcotic Antagonists; Opioid Peptides; Pain Measurement; Peptide Fragments; Peptides; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid, mu; Somatostatin

2003
Activity of opioid ligands in cells expressing cloned mu opioid receptors.
    BMC pharmacology, 2003, Jan-04, Volume: 3

    Topics: Azocines; beta-Endorphin; Binding, Competitive; Butorphanol; Cell Line; Colforsin; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Etorphine; Fentanyl; Humans; Hydromorphone; Ligands; Morphine; Naltrexone; Phenazocine; Radioligand Assay; Receptors, Opioid, mu; Tritium

2003
Effects of beta-funaltrexamine and naloxonazine on single-trial morphine-conditioned place preference and locomotor activity.
    Pharmacology, biochemistry, and behavior, 2003, Volume: 74, Issue:3

    Topics: Animals; Conditioning, Psychological; Male; Morphine; Motor Activity; Naloxone; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu

2003
Role of kappa-opioid receptor activation in pharmacological preconditioning of swine.
    American journal of physiology. Heart and circulatory physiology, 2003, Volume: 284, Issue:6

    Topics: Animals; Arrhythmias, Cardiac; Coronary Circulation; Enkephalin, Leucine-2-Alanine; Hemodynamics; Ischemic Preconditioning, Myocardial; Morphine; Myocardial Infarction; Myocardial Ischemia; Naltrexone; Narcotic Antagonists; Narcotics; Pentazocine; Receptors, Opioid, kappa; Swine

2003
Discriminative stimulus and antinociceptive effects of dihydroetorphine in rhesus monkeys.
    Psychopharmacology, 2003, Volume: 166, Issue:4

    Topics: Analgesics, Opioid; Animals; Discrimination Learning; Etorphine; Female; Macaca mulatta; Male; Morphine; Naltrexone

2003
Discrimination of a single dose of morphine followed by naltrexone: substitution of other agonists for morphine and other antagonists for naltrexone in a rat model of acute dependence.
    The Journal of pharmacology and experimental therapeutics, 2003, Volume: 304, Issue:3

    Topics: Acute Disease; Analgesics, Opioid; Animals; Disease Models, Animal; Fentanyl; Male; Methadone; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Substance-Related Disorders

2003
Adenosine and opioid receptor-mediated cardioprotection in the rat: evidence for cross-talk between receptors.
    American journal of physiology. Heart and circulatory physiology, 2003, Volume: 285, Issue:1

    Topics: Adenosine; Analgesics, Opioid; Animals; ATP-Binding Cassette Transporters; Benzylidene Compounds; Free Radicals; Heart Diseases; In Vitro Techniques; KATP Channels; Mitochondria, Heart; Morphine; Myocardial Infarction; Myocardial Reperfusion Injury; Naltrexone; Potassium Channels; Potassium Channels, Inwardly Rectifying; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptor Cross-Talk; Receptors, Opioid, delta; Receptors, Purinergic P1

2003
Opioid agonists have different efficacy profiles for G protein activation, rapid desensitization, and endocytosis of mu-opioid receptors.
    The Journal of biological chemistry, 2003, May-23, Volume: 278, Issue:21

    Topics: Animals; Calcium Channel Blockers; Calcium Channels; Electric Conductivity; Endocytosis; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; GTP-Binding Proteins; Methadone; Mice; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Neuroblastoma; Pentazocine; Pituitary Neoplasms; Receptors, Opioid, mu; Transfection; Tumor Cells, Cultured

2003
Discriminative stimulus effects of acute morphine followed by naltrexone in the squirrel monkey.
    Psychopharmacology, 2003, Volume: 167, Issue:2

    Topics: Animals; Benzeneacetamides; Conditioning, Operant; Dextrorphan; Discrimination Learning; Dose-Response Relationship, Drug; Generalization, Psychological; Levorphanol; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pyrrolidines; Receptors, Opioid; Saimiri; Substance Withdrawal Syndrome

2003
Use of irreversible antagonists to determine the relative efficacy of mu-opioids in a pigeon drug discrimination procedure: comparison of beta-funaltrexamine and clocinnamox.
    The Journal of pharmacology and experimental therapeutics, 2003, Volume: 305, Issue:3

    Topics: Animals; Cinnamates; Columbidae; Female; Fentanyl; Methadone; Morphine; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Narcotics; Reaction Time; Receptors, Opioid, mu; Sufentanil

2003
Activation of kappa-opioid receptors inhibits pruritus evoked by subcutaneous or intrathecal administration of morphine in monkeys.
    The Journal of pharmacology and experimental therapeutics, 2003, Volume: 305, Issue:1

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Disease Models, Animal; Drug Interactions; Female; Injections, Spinal; Injections, Subcutaneous; Macaca mulatta; Male; Morphine; Naltrexone; Narcotic Antagonists; Pruritus; Receptors, Opioid, kappa

2003
Regulation of RGS proteins by chronic morphine in rat locus coeruleus.
    The European journal of neuroscience, 2003, Volume: 17, Issue:5

    Topics: Animals; Blotting, Western; Immunohistochemistry; In Situ Hybridization; Locus Coeruleus; Male; Membrane Potentials; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Neurons; Organ Culture Techniques; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; RGS Proteins; RNA, Messenger; Substance Withdrawal Syndrome

2003
Effects of heroin and its metabolites on schedule-controlled responding and thermal nociception in rhesus monkeys: sensitivity to antagonism by quadazocine, naltrindole and beta-funaltrexamine.
    Drug and alcohol dependence, 2003, May-01, Volume: 70, Issue:1

    Topics: Animals; Azocines; Behavior, Animal; Dose-Response Relationship, Drug; Food; Heroin; Hot Temperature; Macaca mulatta; Morphine; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Pain Measurement

2003
Opioids and the apoptotic pathway in human cancer cells.
    Neuropeptides, 2003, Volume: 37, Issue:2

    Topics: Annexin A5; Apoptosis; Cell Adhesion; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Etorphine; Growth Substances; Humans; In Situ Nick-End Labeling; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Necrosis; Neoplasms; Tumor Cells, Cultured

2003
Relative efficacy of buprenorphine, nalbuphine and morphine in opioid-treated rhesus monkeys discriminating naltrexone.
    The Journal of pharmacology and experimental therapeutics, 2003, Volume: 306, Issue:3

    Topics: Animals; Buprenorphine; Conditioning, Operant; Discrimination Learning; Female; Macaca mulatta; Male; Methadyl Acetate; Morphine; Nalbuphine; Naltrexone; Narcotics; Receptors, Opioid, mu

2003
Effects of in vitro and in vivo opioids on the production of IL-12 and IL-10 by murine macrophages.
    Annals of the New York Academy of Sciences, 2003, Volume: 992

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enzyme-Linked Immunosorbent Assay; Interleukin-10; Interleukin-12; Macrophages, Peritoneal; Male; Mice; Mice, Inbred BALB C; Morphine; Naltrexone; Pain

2003
Morphine withdrawal precipitated by specific mu, delta or kappa opioid receptor antagonists: a c-Fos protein study in the rat central nervous system.
    The European journal of neuroscience, 2003, Volume: 17, Issue:11

    Topics: Animals; Behavior, Animal; Cell Count; Central Nervous System; Gene Expression Regulation; Immunohistochemistry; Male; Morphine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Narcotics; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome

2003
Morphine enhances hepatitis C virus (HCV) replicon expression.
    The American journal of pathology, 2003, Volume: 163, Issue:3

    Topics: Antiviral Agents; Enzyme Activation; Gene Expression; Hepacivirus; Humans; Interferon-alpha; Morphine; Naltrexone; Narcotic Antagonists; NF-kappa B; Receptors, Opioid, mu; Replicon; RNA, Messenger; Tumor Cells, Cultured

2003
Expression of EGFP-amino-tagged human mu opioid receptor in Drosophila Schneider 2 cells: a potential expression system for large-scale production of G-protein coupled receptors.
    Protein expression and purification, 2003, Volume: 31, Issue:1

    Topics: Animals; Binding, Competitive; Blotting, Western; Cell Line; Cloning, Molecular; Colforsin; Copper Sulfate; Cyclic AMP; Diprenorphine; DNA, Complementary; Drosophila; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Gene Expression; Genetic Vectors; Green Fluorescent Proteins; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Luminescent Proteins; Metallothionein; Microscopy, Confocal; Morphine; Naloxone; Naltrexone; Oligopeptides; Opioid Peptides; Pertussis Toxin; Polymerase Chain Reaction; Protein Binding; Receptors, G-Protein-Coupled; Receptors, Opioid, mu; Recombinant Fusion Proteins; Spectrometry, Fluorescence; Thermodynamics

2003
Blood morphine levels in naltrexone-exposed compared to non-naltrexone-exposed fatal heroin overdoses.
    Addiction biology, 2003, Volume: 8, Issue:3

    Topics: Adult; Australia; Cohort Studies; Drug Overdose; Female; Heroin; Heroin Dependence; Humans; Male; Morphine; Naltrexone; Narcotic Antagonists; Registries; Retrospective Studies; Time Factors

2003
Involvement of central mu-opioid system in the scratching behavior in mice, and the suppression of it by the activation of kappa-opioid system.
    European journal of pharmacology, 2003, Sep-05, Volume: 477, Issue:1

    Topics: Animals; Antipruritics; Behavior, Animal; Injections, Intraventricular; Injections, Subcutaneous; Ketotifen; Male; Mice; Morphinans; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Pruritus; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spiro Compounds; Substance P

2003
Dynorphinergic mechanism mediating endomorphin-2-induced antianalgesia in the mouse spinal cord.
    The Journal of pharmacology and experimental therapeutics, 2003, Volume: 307, Issue:3

    Topics: Analgesics, Opioid; Animals; Antibodies, Blocking; Dizocilpine Maleate; Dose-Response Relationship, Drug; Dynorphins; Excitatory Amino Acid Antagonists; Injections, Spinal; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain Measurement; Reaction Time; Receptors, Opioid; Spinal Cord

2003
Characterization of scratching responses in rats following centrally administered morphine or bombesin.
    Behavioural pharmacology, 2003, Volume: 14, Issue:7

    Topics: Analgesics, Opioid; Animals; Antipruritics; Bombesin; Brain; Dose-Response Relationship, Drug; Grooming; Injections, Intraventricular; Injections, Spinal; Male; Morphine; Naltrexone; Narcotic Antagonists; Premedication; Rats; Rats, Wistar; Receptors, Opioid, mu; Spinal Cord; Stereotyped Behavior

2003
Methylnaltrexone antagonizes opioid-mediated enhancement of HIV infection of human blood mononuclear phagocytes.
    The Journal of pharmacology and experimental therapeutics, 2003, Volume: 307, Issue:3

    Topics: Cells, Cultured; HIV Infections; HIV Reverse Transcriptase; Humans; Monocytes; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Quaternary Ammonium Compounds; Receptors, CCR5

2003
Cocaine and other indirect-acting monoamine agonists differentially attenuate a naltrexone discriminative stimulus in morphine-treated rhesus monkeys.
    The Journal of pharmacology and experimental therapeutics, 2004, Volume: 308, Issue:1

    Topics: Amphetamine; Animals; Biogenic Monoamines; Cocaine; Discrimination Learning; Disease Models, Animal; Dopamine Agents; Dopamine Uptake Inhibitors; Drug Interactions; Imipramine; Macaca mulatta; Morphine; Morphine Dependence; Naltrexone; Narcotics; Substance Withdrawal Syndrome

2004
Effect of opioid receptor ligands on the mu-S196A knock-in and mu knockout mouse vas deferens.
    European journal of pharmacology, 2003, Oct-08, Volume: 478, Issue:2-3

    Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Enkephalin, Leucine-2-Alanine; In Vitro Techniques; Ligands; Male; Mice; Mice, Knockout; Mice, Transgenic; Morphine; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Receptors, Opioid; Vas Deferens

2003
Basal signaling activity of mu opioid receptor in mouse brain: role in narcotic dependence.
    The Journal of pharmacology and experimental therapeutics, 2004, Volume: 308, Issue:2

    Topics: Adenylyl Cyclases; Animals; Brain; Disease Models, Animal; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice; Mice, Inbred ICR; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Receptors, Opioid, mu; Signal Transduction; Substance Withdrawal Syndrome; Sulfur Radioisotopes

2004
Delta opioid receptors are involved in morphine-induced inhibition of luteinizing hormone releasing hormone in SK-N-SH cells.
    Neuropeptides, 2003, Volume: 37, Issue:5

    Topics: Analgesics, Opioid; Cell Line, Tumor; Dose-Response Relationship, Drug; Gonadotropin-Releasing Hormone; Humans; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Neuroblastoma; Receptors, Opioid, delta; Somatostatin

2003
Characterization and opioid modulation of inflammatory temporomandibular joint pain in the rat.
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 2003, Volume: 61, Issue:11

    Topics: Analgesics, Opioid; Animals; Arthritis, Experimental; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Grooming; Head Movements; Male; Mastication; Morphine; Mustard Plant; Naltrexone; Narcotic Antagonists; Neural Pathways; Nociceptors; Pain; Plant Extracts; Plant Oils; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Temporomandibular Joint Disorders; Trigeminal Caudal Nucleus

2003
[Comparison of the antagonistic effects of 6 beta-naltrexol and naltrexone against morphine analgesia].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2003, Volume: 38, Issue:8

    Topics: Analgesia; Analgesics, Opioid; Animals; Female; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Pain Threshold; Receptors, Opioid, mu

2003
Opioid partial agonist effects of 3-O-methylnaltrexone in rhesus monkeys.
    The Journal of pharmacology and experimental therapeutics, 2004, Volume: 308, Issue:3

    Topics: Adenylyl Cyclases; Animals; Cocaine; Discrimination Learning; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Heroin; Heroin Dependence; Macaca mulatta; Male; Morphine; Morphine Derivatives; Naltrexone; Narcotics; Quaternary Ammonium Compounds; Receptors, Opioid, mu; Self Administration

2004
Opioid modulation of scratching and spinal c-fos expression evoked by intradermal serotonin.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Nov-26, Volume: 23, Issue:34

    Topics: Analgesics, Opioid; Animals; Behavior, Animal; Hindlimb; Injections, Intradermal; Male; Microinjections; Morphine; Naltrexone; Narcotic Antagonists; Neck; Posterior Horn Cells; Proto-Oncogene Proteins c-fos; Pruritus; Rats; Rats, Sprague-Dawley; Serotonin; Spinal Cord

2003
Sex differences in opioid-induced enhancement of contact hypersensitivity.
    The Journal of investigative dermatology, 2003, Volume: 121, Issue:5

    Topics: Animals; Buprenorphine; Castration; Dermatitis, Contact; Etorphine; Female; Gonadal Steroid Hormones; Male; Morphine; Naltrexone; Rats; Rats, Inbred F344; Receptors, Opioid, mu; Sex Characteristics

2003
Effects of morphine and naltrexone on impulsive decision making in rats.
    Psychopharmacology, 2004, Volume: 173, Issue:1-2

    Topics: Analgesics, Opioid; Analysis of Variance; Animals; Behavior, Animal; Decision Making; Dose-Response Relationship, Drug; Drug Interactions; Impulsive Behavior; Male; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley

2004
Nonopioidergic mechanism mediating morphine-induced antianalgesia in the mouse spinal cord.
    The Journal of pharmacology and experimental therapeutics, 2004, Volume: 310, Issue:1

    Topics: Analgesia; Animals; beta-Endorphin; Dizocilpine Maleate; Drug Interactions; Drug Tolerance; Dynorphins; Enkephalins; Male; Mice; Morphine; Naloxone; Naltrexone; Oligopeptides; Pain; Pain Measurement; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord; Substance P

2004
Application of a simple and sensitive GC-MS method for determination of morphine in the hair of opium abusers.
    Analytical and bioanalytical chemistry, 2004, Volume: 379, Issue:1

    Topics: Adult; Gas Chromatography-Mass Spectrometry; Hair; Humans; Iran; Male; Middle Aged; Morphine; Morphine Derivatives; Naltrexone; Opium; Reproducibility of Results; Solvents; Substance Abuse Detection; Time Factors

2004
Methylnaltrexone prevents morphine-induced kaolin intake in the rat.
    Life sciences, 2004, Apr-16, Volume: 74, Issue:22

    Topics: Animals; Antiemetics; Diet; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Injections, Intraperitoneal; Kaolin; Male; Morphine; Naltrexone; Narcotic Antagonists; Ondansetron; Pica; Quaternary Ammonium Compounds; Rats; Rats, Wistar

2004
Supraspinal and spinal cord opioid receptors are responsible for antinociception following intrathecal morphine injections.
    European journal of anaesthesiology, 2004, Volume: 21, Issue:3

    Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Injections, Spinal; Male; Models, Animal; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Pain; Pain Threshold; Random Allocation; Rats; Rats, Wistar; Reaction Time; Receptors, Opioid; Spinal Cord; Tail

2004
Naltrexone antagonism of morphine antinociception in sucrose- and chow-fed rats.
    Nutritional neuroscience, 2004, Volume: 7, Issue:1

    Topics: Analgesics, Opioid; Animal Feed; Animals; Dietary Sucrose; Energy Intake; Male; Morphine; Naltrexone; Pain; Rats; Rats, Long-Evans; Reaction Time

2004
Potentiated startle and hyperalgesia during withdrawal from acute morphine: effects of multiple opiate exposures.
    Psychopharmacology, 2004, Volume: 176, Issue:3-4

    Topics: Acoustic Stimulation; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Hyperalgesia; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain Measurement; Rats; Rats, Sprague-Dawley; Reflex, Startle; Substance Withdrawal Syndrome

2004
The antinociceptive effect of Delta9-tetrahydrocannabinol in the arthritic rat.
    European journal of pharmacology, 2004, Jun-16, Volume: 493, Issue:1-3

    Topics: Animals; Arthritis, Experimental; Cannabinoid Receptor Antagonists; Dose-Response Relationship, Drug; Dronabinol; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Freund's Adjuvant; Injections, Intradermal; Injections, Intraperitoneal; Male; Morphine; Mycobacterium; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Opioid; Rimonabant

2004
Interactions of "ultra-low" doses of naltrexone and morphine in mature and young male and female rats.
    Receptors & channels, 2004, Volume: 10, Issue:2

    Topics: Age Factors; Analgesics, Opioid; Animals; Drug Interactions; Female; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Sex Factors

2004
Direct evidence for the involvement of the mesolimbic kappa-opioid system in the morphine-induced rewarding effect under an inflammatory pain-like state.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2005, Volume: 30, Issue:1

    Topics: Animals; Brain Chemistry; Conditioning, Operant; Dopamine; Dynorphins; Edema; Foot; Formaldehyde; Inflammation; Limbic System; Male; Microdialysis; Microinjections; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reward

2005
The opioid antagonist naltrexone blocks acute endotoxic shock by inhibiting tumor necrosis factor-alpha production.
    Brain, behavior, and immunity, 2004, Volume: 18, Issue:5

    Topics: Analysis of Variance; Animals; Antibodies; Bacterial Toxins; Enterotoxins; fas Receptor; Interleukin-1; Interleukin-6; Lipopolysaccharides; Liver; Macrophages; Male; Mice; Mice, Inbred BALB C; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Shock, Septic; Survival Rate; Tumor Necrosis Factor-alpha

2004
The interaction of cannabinoids and opioids on pentylenetetrazole-induced seizure threshold in mice.
    Neuropharmacology, 2004, Volume: 47, Issue:3

    Topics: Analysis of Variance; Animals; Arachidonic Acids; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cannabinoids; Differential Threshold; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Male; Mice; Mice, Inbred Strains; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Pentylenetetrazole; Piperidines; Pyrazoles; Reaction Time; Receptor, Cannabinoid, CB1; Receptors, Opioid; Seizures; Statistics, Nonparametric; Time Factors

2004
Sex and estrus cycle differences in the modulatory effects of morphine on seizure susceptibility in mice.
    Epilepsia, 2004, Volume: 45, Issue:9

    Topics: Animals; Anticonvulsants; Convulsants; Disease Susceptibility; Dose-Response Relationship, Drug; Estrous Cycle; Female; Gonadal Steroid Hormones; Infusions, Intravenous; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Orchiectomy; Ovariectomy; Pentylenetetrazole; Seizures; Sex Factors

2004
Obstructive cholestasis alters intestinal transit in mice: role of opioid system.
    Life sciences, 2004, Dec-10, Volume: 76, Issue:4

    Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Cholestasis, Extrahepatic; Disease Models, Animal; Drug Therapy, Combination; Gastrointestinal Transit; Injections, Intraperitoneal; Injections, Subcutaneous; Intestine, Small; Male; Mice; Mice, Inbred Strains; Morphine; Naltrexone

2004
Ultra-low dose naltrexone potentiates the anticonvulsant effect of low dose morphine on clonic seizures.
    Neuroscience, 2004, Volume: 129, Issue:3

    Topics: Animals; Differential Threshold; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Pentylenetetrazole; Reaction Time; Seizures

2004
Interactions of galanin and opioids in nociceptive modulation in the arcuate nucleus of hypothalamus in rats.
    Regulatory peptides, 2005, Jan-15, Volume: 124, Issue:1-3

    Topics: Analgesics, Opioid; Animals; Arcuate Nucleus of Hypothalamus; Dose-Response Relationship, Drug; Galanin; Hindlimb; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Pain; Rats; Rats, Wistar; Receptors, Opioid

2005
The development of tolerance to locomotor effects of morphine and the effect of various opioid receptor antagonists in rats chronically treated with morphine.
    Brain research bulletin, 2005, Jan-15, Volume: 64, Issue:5

    Topics: Animals; Behavior, Animal; Drug Interactions; Male; Morphine; Morphine Dependence; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Wistar; Time Factors

2005
Lack of evidence for mu-opioid regulation of a socially mediated separation response.
    Physiology & behavior, 2005, Jan-17, Volume: 83, Issue:5

    Topics: Animals; Dose-Response Relationship, Drug; Female; Male; Maternal Deprivation; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Wistar; Receptors, Opioid, mu; Social Environment; Social Isolation; Ultrasonics; Vocalization, Animal

2005
Characterisation of opioid receptors involved in modulating circular and longitudinal muscle contraction in the rat ileum.
    British journal of pharmacology, 2005, Volume: 144, Issue:5

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enteric Nervous System; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Muscle Contraction; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu

2005
In vivo characterization of 6beta-naltrexol, an opioid ligand with less inverse agonist activity compared with naltrexone and naloxone in opioid-dependent mice.
    The Journal of pharmacology and experimental therapeutics, 2005, Volume: 313, Issue:3

    Topics: Animals; Benzylidene Compounds; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice; Mice, Inbred ICR; Morphine; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders

2005
Sensitization to morphine withdrawal in guinea-pigs.
    European journal of pharmacology, 2005, Feb-21, Volume: 509, Issue:2-3

    Topics: Amygdala; Analgesics, Opioid; Analysis of Variance; Animals; Behavior, Animal; Body Weight; Brain Chemistry; Cerebral Cortex; Guinea Pigs; Hippocampus; Hypothalamus; Immunohistochemistry; Male; Morphine; Motor Activity; Naltrexone; Proto-Oncogene Proteins c-fos; Rats; Substance Withdrawal Syndrome; Telencephalon; Time Factors

2005
Naltrexone treatment of combined alcohol and opioid dependence: deterioration of co-morbid major depression.
    Pharmacopsychiatry, 2005, Volume: 38, Issue:2

    Topics: Alcoholism; Amitriptyline; Depressive Disorder, Major; Ethanol; Humans; Male; Middle Aged; Morphine; Morphine Dependence; Naltrexone; Narcotics; Severity of Illness Index; Substance Withdrawal Syndrome

2005
In vivo activation of a mutant mu-opioid receptor by naltrexone produces a potent analgesic effect but no tolerance: role of mu-receptor activation and delta-receptor blockade in morphine tolerance.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005, Mar-23, Volume: 25, Issue:12

    Topics: Animals; Benzamides; Dose-Response Relationship, Drug; Drug Delivery Systems; Drug Interactions; Drug Tolerance; Mice; Mice, Transgenic; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Pain Measurement; Piperazines; Receptors, Opioid, mu

2005
Discriminative stimulus effects of acute morphine followed by naltrexone in the squirrel monkey: a further characterization.
    The Journal of pharmacology and experimental therapeutics, 2005, Volume: 314, Issue:1

    Topics: Analgesics, Opioid; Animals; Buprenorphine; Diprenorphine; Discrimination, Psychological; Dose-Response Relationship, Drug; Drinking; Drug Interactions; Generalization, Stimulus; Male; Meperidine; Mice; Morphine; Nalbuphine; Nalorphine; Naltrexone; Narcotic Antagonists; Saimiri; Water Deprivation

2005
Naltrexone-induced conditioned place aversion following a single dose of morphine in the rat.
    Pharmacology, biochemistry, and behavior, 2005, Volume: 81, Issue:3

    Topics: Analgesics, Opioid; Animals; Behavior, Animal; Conditioning, Operant; Dose-Response Relationship, Drug; Male; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Time Factors

2005
Opioid antagonists differ according to negative intrinsic efficacy in a mouse model of acute dependence.
    British journal of pharmacology, 2005, Volume: 145, Issue:7

    Topics: Animals; Behavior, Animal; Body Weight; Brain; Diprenorphine; Dose-Response Relationship, Drug; Male; Mice; Morphine; Morphine Dependence; Naloxone; Naltrexone; Narcotic Antagonists; Substance Withdrawal Syndrome; Tremor

2005
The role of central and peripheral mu opioid receptors in inflammatory pain and edema: a study using morphine and DiPOA ([8-(3,3-diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triaza-spiro[4.5]dec-3-yl]-acetic acid).
    The Journal of pharmacology and experimental therapeutics, 2005, Volume: 314, Issue:3

    Topics: Acetates; Animals; Aza Compounds; Brain; Carrageenan; Edema; Injections, Intraventricular; Male; Morphine; Naltrexone; Pain; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Spiro Compounds

2005
Effect of repeated administrations of heroin, naltrexone, methadone, and alcohol on morphine glucuronidation in the rat.
    Psychopharmacology, 2005, Volume: 182, Issue:1

    Topics: Animals; Ethanol; Heroin; Heroin Dependence; Male; Methadone; Microsomes, Liver; Morphine; Morphine Derivatives; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu

2005
Morphine inhibits CD8+ T cell-mediated, noncytolytic, anti-HIV activity in latently infected immune cells.
    Journal of leukocyte biology, 2005, Volume: 78, Issue:3

    Topics: Anti-HIV Agents; CD8-Positive T-Lymphocytes; Cell Line; HIV Infections; HIV-1; Humans; Interferon-gamma; Jurkat Cells; Morphine; Naltrexone; STAT1 Transcription Factor

2005
In vitro electrophysiologic effects of morphine in rabbit ventricular myocytes.
    Anesthesiology, 2005, Volume: 103, Issue:2

    Topics: Action Potentials; Animals; Calcium; Calcium Channels, L-Type; Female; In Vitro Techniques; Male; Morphine; Myocytes, Cardiac; Naltrexone; Potassium Channels; Rabbits

2005
Evidence for an intrinsic mechanism of antinociceptive tolerance within the ventrolateral periaqueductal gray of rats.
    Neuroscience, 2005, Volume: 135, Issue:1

    Topics: Analgesics; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Formaldehyde; GABA Agonists; GABA-A Receptor Agonists; Male; Medulla Oblongata; Morphine; Muscimol; Naltrexone; Narcotic Antagonists; Neurons; Pain Measurement; Periaqueductal Gray; Rats; Rats, Sprague-Dawley

2005
Effects of opioid antagonists and morphine in a hippocampal hypoxia/hypoglycemia model.
    Neuropharmacology, 2005, Volume: 49, Issue:8

    Topics: Analgesics, Opioid; Animals; Brain Chemistry; Evoked Potentials; Hippocampus; Hypoglycemia; Hypoxia, Brain; In Vitro Techniques; Male; Morphine; Naltrexone; Narcotic Antagonists; Neuroprotective Agents; Neurotoxicity Syndromes; Rats; Rats, Wistar; Reperfusion Injury

2005
Barium potentiates the conditioned aversion to, but not the somatic signs of, morphine withdrawal in mice.
    European journal of pharmacology, 2005, Sep-20, Volume: 519, Issue:3

    Topics: Animals; Barium; Behavior, Animal; Cerebral Cortex; Conditioning, Operant; Dopamine; Dose-Response Relationship, Drug; Drug Synergism; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Narcotic Antagonists; Norepinephrine; Prosencephalon; Substance Withdrawal Syndrome

2005
Attenuation of post-ischemia reperfusion injury by thaliporphine and morphine in rat hearts.
    Journal of biomedical science, 2005, Volume: 12, Issue:4

    Topics: Adenosine Triphosphate; Analgesics, Opioid; Animals; Antioxidants; Aporphines; Creatine Kinase; Dose-Response Relationship, Drug; Heart; Male; Mitochondria; Morphine; Myocardial Ischemia; Myocardium; Naloxone; Naltrexone; Narcotic Antagonists; Peroxidase; Plant Extracts; Potassium; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Risk; Time Factors

2005
Habituation to test procedure modulates the involvement of dopamine D2- but not D1-receptors in ethanol-induced locomotor stimulation in mice.
    Psychopharmacology, 2005, Volume: 182, Issue:3

    Topics: Amphetamine; Animals; Benzazepines; beta-Endorphin; Caffeine; Environment; Ethanol; Exploratory Behavior; Habituation, Psychophysiologic; Male; Mice; Morphine; Motor Activity; Naltrexone; Receptors, Dopamine D1; Receptors, Dopamine D2; Sulpiride

2005
Antinociception, tolerance and withdrawal symptoms induced by 7-hydroxymitragynine, an alkaloid from the Thai medicinal herb Mitragyna speciosa.
    Life sciences, 2005, Nov-19, Volume: 78, Issue:1

    Topics: Analgesics; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Injections, Subcutaneous; Male; Mice; Mitragyna; Models, Molecular; Morphinans; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Reaction Time; Secologanin Tryptamine Alkaloids; Substance Withdrawal Syndrome; Thailand

2005
Differential effects of morphine and naltrexone on the in vitro LH secretion from male and female carp pituitary gland.
    Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 2005, Volume: 141, Issue:4

    Topics: Animals; Carps; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Luteinizing Hormone; Male; Morphine; Naltrexone; Narcotic Antagonists; Pituitary Gland

2005
Chronic morphine treatment promotes specific Th2 cytokine production by murine T cells in vitro via a Fas/Fas ligand-dependent mechanism.
    Journal of immunology (Baltimore, Md. : 1950), 2005, Oct-15, Volume: 175, Issue:8

    Topics: Animals; Antibodies; Apoptosis; Apoptosis Regulatory Proteins; Cell Differentiation; Cytokines; Fas Ligand Protein; fas Receptor; Female; Interleukin-13; Interleukin-4; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Morphine; Naltrexone; Narcotics; Receptors, Tumor Necrosis Factor; RNA, Messenger; Th2 Cells; TNF-Related Apoptosis-Inducing Ligand; Tumor Necrosis Factor-alpha; Tumor Necrosis Factors

2005
Antinociceptive effect of oxycodone in diabetic mice.
    European journal of pharmacology, 2005, Nov-07, Volume: 524, Issue:1-3

    Topics: Analgesics, Opioid; Animals; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Narcotic Antagonists; Oxycodone; Pain; Pain Measurement; Time Factors

2005
Attenuation of morphine withdrawal signs by intracerebral administration of 18-methoxycoronaridine.
    European journal of pharmacology, 2005, Nov-21, Volume: 525, Issue:1-3

    Topics: Animals; Brain; Drug Administration Routes; Female; Ibogaine; Locus Coeruleus; Morphine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome

2005
Involvement of cAMP/cAMP-dependent protein kinase signaling pathway in regulation of Na+,K+-ATPase upon activation of opioid receptors by morphine.
    Molecular pharmacology, 2006, Volume: 69, Issue:3

    Topics: Adenylyl Cyclases; Animals; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Down-Regulation; Enzyme Inhibitors; Hippocampus; Isoquinolines; Male; Mice; Mice, Inbred Strains; Molecular Mimicry; Morphine; Naltrexone; Okadaic Acid; Pertussis Toxin; Phosphoprotein Phosphatases; Protein Biosynthesis; Protein Kinase Inhibitors; Receptors, Opioid; Signal Transduction; Sodium-Potassium-Exchanging ATPase; Sulfonamides

2006
Opioid-induced tolerance and dependence in mice is modulated by the distance between pharmacophores in a bivalent ligand series.
    Proceedings of the National Academy of Sciences of the United States of America, 2005, Dec-27, Volume: 102, Issue:52

    Topics: Analgesics; Analgesics, Opioid; Animals; Chemistry, Pharmaceutical; Dose-Response Relationship, Drug; Ligands; Male; Mice; Mice, Inbred ICR; Models, Chemical; Models, Statistical; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Receptors, Opioid, delta; Receptors, Opioid, mu; Time Factors

2005
Elevated mu-opioid receptor expression in the nucleus of the solitary tract accompanies attenuated withdrawal signs after chronic low dose naltrexone in opiate-dependent rats.
    Journal of neuroscience research, 2006, Feb-15, Volume: 83, Issue:3

    Topics: Animals; Behavior, Animal; Blotting, Western; CREB-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Interactions; Gene Expression; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Prosencephalon; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Solitary Nucleus; Substance Withdrawal Syndrome; Time Factors

2006
Morphine hyperalgesia in mice is unrelated to opioid activity, analgesia, or tolerance: evidence for multiple diverse hyperalgesic systems.
    Brain research, 2006, Jan-27, Volume: 1070, Issue:1

    Topics: Analgesia; Analgesics, Opioid; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Tolerance; Excitatory Amino Acid Antagonists; Hyperalgesia; Injections, Subcutaneous; Male; Mice; Mice, Inbred Strains; Morphine; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Nociceptors; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid

2006
Inhibition of morphine tolerance by processed Aconiti tuber is mediated by kappa-opioid receptors.
    Journal of ethnopharmacology, 2006, Jun-30, Volume: 106, Issue:2

    Topics: Aconitum; Analgesics, Opioid; Animals; Cinnamates; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Drugs, Chinese Herbal; Male; Mice; Morphine; Morphine Derivatives; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Pain Threshold; Plant Tubers; Receptors, Opioid, kappa; Time Factors

2006
Involvements of mu- and kappa-opioid receptors in morphine-induced antinociception in the nucleus accumbens of rats.
    Neuroscience letters, 2006, May-15, Volume: 399, Issue:1-2

    Topics: Analgesics, Opioid; Animals; Male; Morphine; Naloxone; Naltrexone; Nucleus Accumbens; Pain; Physical Stimulation; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu

2006
Influence of low doses of naltrexone on morphine antinociception and morphine tolerance in male and female rats of four strains.
    Pain, 2006, Volume: 122, Issue:1-2

    Topics: Analgesics; Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Combinations; Drug Synergism; Drug Tolerance; Female; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain; Pain Threshold; Rats; Rats, Inbred F344; Rats, Long-Evans; Rats, Sprague-Dawley; Sex Factors; Species Specificity

2006
Opioid receptors in the nucleus accumbens regulate attentional learning in the blocking paradigm.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006, Apr-12, Volume: 26, Issue:15

    Topics: Analgesics, Opioid; Animals; Attention; Electroshock; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Learning; Male; Models, Animal; Morphine; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Physical Stimulation; Rats; Rats, Wistar; Receptors, Opioid

2006
Endogenous opioids mediate the hypoalgesia induced by selective inhibitors of cyclo-oxygenase 2 in rat paws treated with carrageenan.
    Neuropharmacology, 2006, Volume: 51, Issue:1

    Topics: Analgesics; Analgesics, Opioid; Animals; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Drug Tolerance; Edema; Endorphins; Foot; Hyperalgesia; Indomethacin; Injections; Injections, Subcutaneous; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Pyrazoles; Rats; Rats, Sprague-Dawley; Rats, Wistar; Signal Transduction; Species Specificity

2006
The involvement of endogenous opioid mechanisms in the antinociceptive effects induced by antidepressant drugs, desipramine and trimipramine.
    Pharmacology, biochemistry, and behavior, 2006, Volume: 83, Issue:4

    Topics: Analgesics; Animals; Antidepressive Agents; Desipramine; Male; Mice; Morphine; Naloxone; Naltrexone; Receptors, Opioid; Receptors, Opioid, delta; Trimipramine

2006
Chronic morphine treatment induces oxidant and apoptotic damage in the mice liver.
    Life sciences, 2006, Aug-01, Volume: 79, Issue:10

    Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Cell Survival; Chronic Disease; Glutathione; Liver; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Oxidative Stress; Pain; Signal Transduction

2006
Food-induced behavioral sensitization, its cross-sensitization to cocaine and morphine, pharmacological blockade, and effect on food intake.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006, Jul-05, Volume: 26, Issue:27

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analgesics, Opioid; Animals; Benzazepines; Benzodiazepines; Cocaine; Conditioning, Psychological; Dopamine Antagonists; Dopamine Uptake Inhibitors; Drug Interactions; Eating; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Feeding Behavior; Male; Mice; Mice, Inbred C57BL; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Receptors, Dopamine D1; Sulpiride

2006
Noradrenaline is necessary for the hedonic properties of addictive drugs.
    Vascular pharmacology, 2006, Volume: 45, Issue:4

    Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Appetitive Behavior; Benzazepines; Biphenyl Compounds; Bupropion; Carbidopa; Cocaine; Dopamine beta-Hydroxylase; Dopamine Uptake Inhibitors; Droxidopa; Female; Genotype; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Knockout; Morphine; Naltrexone; Narcotic Antagonists; Neurokinin-1 Receptor Antagonists; Norepinephrine; Receptors, Adrenergic, alpha-1; Receptors, Dopamine D1; Reward; Substance-Related Disorders

2006
Involvement of mu-opioid receptors in antinociception and inhibition of gastrointestinal transit induced by 7-hydroxymitragynine, isolated from Thai herbal medicine Mitragyna speciosa.
    European journal of pharmacology, 2006, Nov-07, Volume: 549, Issue:1-3

    Topics: Analgesics; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Gastrointestinal Transit; Guinea Pigs; Herbal Medicine; Ileum; Male; Mice; Mitragyna; Molecular Structure; Morphine; Muscle Contraction; Naltrexone; Narcotic Antagonists; Narcotics; Pain; Pain Measurement; Receptors, Opioid, mu; Secologanin Tryptamine Alkaloids; Thailand; Vas Deferens

2006
Morphine upregulates functional expression of neurokinin-1 receptor in neurons.
    Journal of neuroscience research, 2006, Nov-15, Volume: 84, Issue:7

    Topics: Analysis of Variance; Animals; Blotting, Western; Calcium; Cerebral Cortex; Drug Interactions; Embryo, Mammalian; Enzyme Activation; Enzyme Inhibitors; Fluorescent Antibody Technique; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Neurons; p38 Mitogen-Activated Protein Kinases; Peptide Fragments; Peptides; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Opioid, mu; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Somatostatin; Up-Regulation

2006
Expression and localization of delta-, kappa-, and mu-opioid receptors in human spermatozoa and implications for sperm motility.
    The Journal of clinical endocrinology and metabolism, 2006, Volume: 91, Issue:12

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adult; Analgesics, Opioid; Humans; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sperm Motility; Spermatozoa; Tissue Distribution

2006
In vivo pharmacological resultant analysis reveals noncompetitive interactions between opioid antagonists in the rat tail-withdrawal assay.
    British journal of pharmacology, 2006, Volume: 149, Issue:8

    Topics: Algorithms; Animals; Dose-Response Relationship, Drug; Drug Interactions; Injections, Intraventricular; Injections, Subcutaneous; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Pain Measurement; Peptide Fragments; Peptides; Rats; Rats, Sprague-Dawley; Reaction Time; Somatostatin

2006
Different effects of opioid antagonists on mu-, delta-, and kappa-opioid receptors with and without agonist pretreatment.
    The Journal of pharmacology and experimental therapeutics, 2007, Volume: 321, Issue:2

    Topics: Benzylidene Compounds; Cells, Cultured; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Morphine; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Signal Transduction

2007
Local opioids in a model of periodontal disease in rats.
    Archives of oral biology, 2007, Volume: 52, Issue:7

    Topics: Alveolar Bone Loss; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Gingiva; Injections; Injections, Subcutaneous; Leukocyte Count; Male; Morphine; Naltrexone; Narcotic Antagonists; Neutrophils; Periodontal Attachment Loss; Periodontal Diseases; Rats; Rats, Sprague-Dawley; Receptors, Opioid

2007
Inhibition of tolerance to spinal morphine antinociception by low doses of opioid receptor antagonists.
    European journal of pharmacology, 2007, Apr-10, Volume: 560, Issue:2-3

    Topics: Animals; Dose-Response Relationship, Drug; Drug Tolerance; Hyperalgesia; Injections, Spinal; Male; Morphine; Naltrexone; Narcotic Antagonists; Peptide Fragments; Peptides; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Somatostatin; Theophylline

2007
Nucleus accumbens opioid signaling conditions short-term flavor preferences.
    Neuroscience, 2007, Apr-25, Volume: 146, Issue:1

    Topics: Analgesics, Opioid; Analysis of Variance; Animals; Behavior, Animal; Conditioning, Operant; Eating; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Food Preferences; GABA Agonists; Male; Morphine; Muscimol; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Rats; Rats, Long-Evans; Signal Transduction; Taste; Time Factors

2007
History of cocaine self-administration alters morphine reinforcement in the rat.
    European journal of pharmacology, 2007, May-07, Volume: 562, Issue:1-2

    Topics: Analysis of Variance; Animals; Cocaine; Conditioning, Operant; Dose-Response Relationship, Drug; Infusions, Intravenous; Injections, Intraperitoneal; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Self Administration

2007
The in vitro pharmacology of the peripherally restricted opioid receptor antagonists, alvimopan, ADL 08-0011 and methylnaltrexone.
    Naunyn-Schmiedeberg's archives of pharmacology, 2007, Volume: 375, Issue:3

    Topics: Analgesics, Opioid; Animals; Benzeneacetamides; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Morphine; Muscle Contraction; Naltrexone; Narcotic Antagonists; Oligopeptides; Piperidines; Pyrrolidines; Quaternary Ammonium Compounds; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Proteins; Transfection

2007
Lobeline, a potential pharmacotherapy for drug addiction, binds to mu opioid receptors and diminishes the effects of opioid receptor agonists.
    Drug and alcohol dependence, 2007, Jul-10, Volume: 89, Issue:2-3

    Topics: Analgesics, Opioid; Animals; Binding, Competitive; Brain; Dopamine; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Guinea Pigs; In Vitro Techniques; Lobeline; Mecamylamine; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Nicotine; Oocytes; Radioligand Assay; Receptors, Opioid; Receptors, Opioid, mu; Xenopus laevis

2007
Absence of conditioned place preference or reinstatement with bivalent ligands containing mu-opioid receptor agonist and delta-opioid receptor antagonist pharmacophores.
    European journal of pharmacology, 2007, Jul-02, Volume: 566, Issue:1-3

    Topics: Analgesics, Opioid; Animals; Behavior, Animal; Conditioning, Psychological; Ligands; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Narcotic Antagonists; Oxymorphone; Pain; Receptors, Opioid, delta; Receptors, Opioid, mu

2007
Attenuation of vascular permeability by methylnaltrexone: role of mOP-R and S1P3 transactivation.
    American journal of respiratory cell and molecular biology, 2007, Volume: 37, Issue:2

    Topics: Analgesics, Opioid; Animals; Capillary Permeability; Cells, Cultured; Electrophysiology; Endothelial Cells; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Humans; Intracellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Protein Serine-Threonine Kinases; Quaternary Ammonium Compounds; Receptors, Lysosphingolipid; Receptors, Opioid, mu; rho-Associated Kinases; rhoA GTP-Binding Protein; RNA, Small Interfering; Thrombin; Transcriptional Activation

2007
Time-dependent decreases in apparent pA2 values for naltrexone studied in combination with morphine in rhesus monkeys.
    Psychopharmacology, 2007, Volume: 193, Issue:3

    Topics: Animals; Discrimination, Psychological; Dose-Response Relationship, Drug; Female; Macaca mulatta; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Receptors, Opioid, mu; Time Factors

2007
The opioid antagonist, beta-funaltrexamine, inhibits chemokine expression in human astroglial cells.
    Journal of neuroimmunology, 2007, Volume: 186, Issue:1-2

    Topics: Analysis of Variance; Astrocytes; Astrocytoma; Cell Line, Tumor; Cell Survival; Chemokine CXCL10; Chemokines; Chemokines, CXC; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Activation; Enzyme-Linked Immunosorbent Assay; Fentanyl; Humans; Morphine; Naltrexone; Narcotic Antagonists; Narcotics

2007
Sexually dimorphic recruitment of spinal opioid analgesic pathways by the spinal application of morphine.
    The Journal of pharmacology and experimental therapeutics, 2007, Volume: 322, Issue:2

    Topics: Animals; Animals, Newborn; Antibodies; Dose-Response Relationship, Drug; Dynorphins; Female; Injections, Spinal; Male; Morphine; Naltrexone; Narcotic Antagonists; Neural Pathways; Orchiectomy; Ovariectomy; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sex Factors; Spinal Cord; Sufentanil; Virilism

2007
Augmentation of spinal morphine analgesia and inhibition of tolerance by low doses of mu- and delta-opioid receptor antagonists.
    British journal of pharmacology, 2007, Volume: 151, Issue:6

    Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Injections, Spinal; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Peptide Fragments; Peptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Somatostatin

2007
Electron density analyses of opioids: a comparative study.
    The journal of physical chemistry. A, 2007, Jun-28, Volume: 111, Issue:25

    Topics: Analgesics, Opioid; Codeine; Cold Temperature; Dextromethorphan; Diprenorphine; Electrons; Models, Molecular; Morphine; Naltrexone; X-Ray Diffraction

2007
Maternal separation alters ICSS responding in adult male and female rats, but morphine and naltrexone have little affect on that behavior.
    Brain research bulletin, 2007, Jul-12, Volume: 73, Issue:4-6

    Topics: Analgesics, Opioid; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Female; Humans; Male; Maternal Deprivation; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Long-Evans; Self Stimulation; Sex Factors

2007
Effects of loperamide on mechanical allodynia induced by herpes simplex virus type-1 in mice.
    Journal of pharmacological sciences, 2007, Volume: 104, Issue:3

    Topics: Analgesics, Opioid; Animals; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Drug Tolerance; Female; Foot; Herpes Simplex; Herpesvirus 1, Human; Injections; Injections, Subcutaneous; Loperamide; Mice; Mice, Inbred C57BL; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Physical Stimulation

2007
A tarantula peptide against pain via ASIC1a channels and opioid mechanisms.
    Nature neuroscience, 2007, Volume: 10, Issue:8

    Topics: Acid Sensing Ion Channels; Analgesics; Animals; Area Under Curve; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Enkephalins; Membrane Proteins; Mice; Mice, Knockout; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Nerve Tissue Proteins; Neurons; Pain; Pain Measurement; Peptides; Protein Precursors; Reaction Time; Sodium Channels; Spider Venoms; Spinal Cord; Time Factors

2007
Increase in diazepam binding inhibitor expression by sustained morphine exposure is mediated via mu-opioid receptors in primary cultures of mouse cerebral cortical neurons.
    Journal of neuroscience research, 2007, Volume: 85, Issue:13

    Topics: Analysis of Variance; Animals; Cells, Cultured; Cerebral Cortex; Diazepam Binding Inhibitor; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; Enzyme Inhibitors; Gene Expression Regulation; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Neurons; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors

2007
Morphine inhibits intrahepatic interferon- alpha expression and enhances complete hepatitis C virus replication.
    The Journal of infectious diseases, 2007, Sep-01, Volume: 196, Issue:5

    Topics: Cells, Cultured; Dose-Response Relationship, Drug; Down-Regulation; Gene Expression Regulation; Hepacivirus; Hepatocytes; Humans; Interferon Regulatory Factors; Interferon-alpha; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Virus Replication

2007
Naloxone rapidly evokes endogenous kappa opioid receptor-mediated hyperalgesia in naïve mice pretreated briefly with GM1 ganglioside or in chronic morphine-dependent mice.
    Brain research, 2007, Sep-05, Volume: 1167

    Topics: Analgesics, Opioid; Animals; Chronic Disease; Dipeptides; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Synergism; G(M1) Ganglioside; Hyperalgesia; Male; Mice; Morphine; Morphine Dependence; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Opioid Peptides; Receptors, Opioid, kappa; Substance Withdrawal Syndrome

2007
Mu-opioid receptor up-regulation and functional supersensitivity are independent of antagonist efficacy.
    The Journal of pharmacology and experimental therapeutics, 2007, Volume: 323, Issue:2

    Topics: Animals; Dose-Response Relationship, Drug; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu; Substance Withdrawal Syndrome; Up-Regulation

2007
Involvement of kappa opioid receptors in formalin-induced inhibition of analgesic tolerance to morphine in mice.
    The Journal of pharmacy and pharmacology, 2007, Volume: 59, Issue:8

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Chronic Disease; Drug Tolerance; Formaldehyde; Male; Mice; Morphine; Naltrexone; Oligonucleotides, Antisense; Pain; Pain Measurement; Pain Threshold; Receptors, Opioid, delta; Receptors, Opioid, kappa; Tail

2007
Intramuscular administration of morphine reduces mustard-oil-induced craniofacial-muscle pain behavior in lightly anesthetized rats.
    European journal of pain (London, England), 2008, Volume: 12, Issue:3

    Topics: Analgesics; Anesthesia, General; Animals; Inflammation; Injections; Injections, Intramuscular; Male; Masseter Muscle; Morphine; Mustard Plant; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Pain; Plant Oils; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Single-Blind Method; Somatostatin

2008
Comparison of naltrexone, 6alpha-naltrexol, and 6beta-naltrexol in morphine-dependent and in nondependent rhesus monkeys.
    Psychopharmacology, 2008, Volume: 195, Issue:4

    Topics: Animals; Appetitive Behavior; Discrimination Learning; Dose-Response Relationship, Drug; Drug Inverse Agonism; Female; Macaca mulatta; Male; Morphine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu

2008
Use of preproenkephalin knockout mice and selective inhibitors of enkephalinases to investigate the role of enkephalins in various behaviours.
    Psychopharmacology, 2008, Volume: 196, Issue:2

    Topics: Analysis of Variance; Animals; Behavior, Animal; CD13 Antigens; Disulfides; Dose-Response Relationship, Drug; Enkephalins; Enzyme Inhibitors; Injections, Intravenous; Mice; Mice, Inbred DBA; Mice, Knockout; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Neprilysin; Phenylalanine; Protein Precursors; Swimming

2008
Isobolographic analysis of multimodal analgesia in an animal model of visceral acute pain.
    Pharmacology, biochemistry, and behavior, 2008, Volume: 88, Issue:4

    Topics: Acetaminophen; Acute Disease; Adrenergic alpha-Antagonists; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Atropine; Behavior, Animal; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Ketoprofen; Male; Mice; Morphine; Muscarinic Antagonists; Naltrexone; Narcotic Antagonists; Pain; Prazosin

2008
Opioid receptors are involved in the sedative and antinociceptive effects of hesperidin as well as in its potentiation with benzodiazepines.
    European journal of pharmacology, 2008, Feb-12, Volume: 580, Issue:3

    Topics: Acetic Acid; Alprazolam; Analgesics; Animals; Behavior, Animal; Benzodiazepines; Dose-Response Relationship, Drug; Drug Synergism; Flunitrazepam; Hesperidin; Hypnotics and Sedatives; Injections, Intraperitoneal; Male; Mice; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Receptors, Opioid

2008
Intrathecal antinociceptive interaction between the NMDA antagonist ketamine and the opioids, morphine and biphalin.
    European journal of pain (London, England), 2008, Volume: 12, Issue:5

    Topics: Analgesics; Analgesics, Non-Narcotic; Animals; Drug Synergism; Drug Therapy, Combination; Drug Tolerance; Enkephalins; Excitatory Amino Acid Antagonists; Hot Temperature; Injections, Spinal; Ketamine; Male; Morphine; Naltrexone; Narcotics; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Tail

2008
Morphine postconditioning protects against reperfusion injury in the isolated rat hearts.
    The Journal of surgical research, 2008, Volume: 145, Issue:2

    Topics: Analgesics, Opioid; Animals; Anti-Arrhythmia Agents; Cardiotonic Agents; Decanoic Acids; Dose-Response Relationship, Drug; Hydroxy Acids; In Vitro Techniques; Ischemic Preconditioning, Myocardial; Male; Morphine; Myocardial Infarction; Naloxone; Naltrexone; Narcotic Antagonists; Potassium Channels; Rats; Rats, Sprague-Dawley; Reperfusion Injury

2008
Seizure susceptibility alteration following reversible cholestasis in mice: Modulation by opioids and nitric oxide.
    European journal of pharmacology, 2008, Feb-12, Volume: 580, Issue:3

    Topics: 1-Naphthylisothiocyanate; Alkaline Phosphatase; Animals; Bilirubin; Biomarkers; Cholestasis; Corn Oil; Disease Models, Animal; Disease Susceptibility; Dose-Response Relationship, Drug; Infusions, Intravenous; Intubation, Gastrointestinal; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pentylenetetrazole; Receptors, Opioid; Seizures; Time Factors

2008
Blockade of micro-opioid receptors in the medial thalamus inhibits acquisition, but not expression, of morphine-induced conditioned place preference.
    Neuroscience, 2008, Feb-19, Volume: 151, Issue:4

    Topics: Animals; Behavior, Animal; Conditioning, Operant; Drug Administration Routes; Drug Interactions; Male; Microinjections; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Thalamus

2008
Comparison of the opioid receptor antagonist properties of naltrexone and 6 beta-naltrexol in morphine-naïve and morphine-dependent mice.
    European journal of pharmacology, 2008, Mar-31, Volume: 583, Issue:1

    Topics: Animals; Binding, Competitive; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred ICR; Morphinans; Morphine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Narcotics; Pain Measurement; Pyrroles; Receptors, Opioid, mu; Substance Withdrawal Syndrome

2008
The comparison of effects of processed Aconiti tuber, U50488H and MK-801 on the antinociceptive tolerance to morphine.
    Journal of ethnopharmacology, 2008, Apr-17, Volume: 117, Issue:1

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Aconitum; Analgesics, Opioid; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Tolerance; Male; Mice; Morphine; Naltrexone; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa

2008
Dopamine-independent psychostimulant activity of a delta-agonist.
    Behavioural pharmacology, 2008, Volume: 19, Issue:2

    Topics: Animals; Benzamides; Brain; Central Nervous System Stimulants; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Synergism; Haloperidol; Male; Mice; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Piperazines; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Opioid, delta

2008
Overriding the blockade of antinociceptive actions of opioids in rats treated with extended-release naltrexone.
    Pharmacology, biochemistry, and behavior, 2008, Volume: 89, Issue:4

    Topics: Alcoholism; Analgesics, Opioid; Animals; Delayed-Action Preparations; Drug Interactions; Fentanyl; Humans; Hydrocodone; Male; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Plethysmography, Whole Body; Rats; Rats, Sprague-Dawley; Respiration

2008
The mu opioid receptor mediates morphine-induced tumor necrosis factor and interleukin-6 inhibition in toll-like receptor 2-stimulated monocytes.
    Anesthesia and analgesia, 2008, Volume: 106, Issue:4

    Topics: Cell Separation; Cells, Cultured; Cytokines; Humans; Inflammation; Interleukin-6; Monocytes; Morphine; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu; Toll-Like Receptor 2; Tumor Necrosis Factor-alpha

2008
Sex differences in hyperalgesia during morphine infusion: effect of gonadectomy and estrogen treatment.
    Neuropharmacology, 2008, Volume: 54, Issue:8

    Topics: Analgesics, Opioid; Animals; Data Interpretation, Statistical; Dizocilpine Maleate; Dose-Response Relationship, Drug; Estrogens; Excitatory Amino Acid Antagonists; Female; Hyperalgesia; Infusions, Intravenous; Isoquinolines; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Orchiectomy; Ovariectomy; Pain Measurement; Receptors, N-Methyl-D-Aspartate; Sex Characteristics

2008
Morphine-nicotine interaction in conditioned place preference in mice after chronic nicotine exposure.
    European journal of pharmacology, 2008, Jun-10, Volume: 587, Issue:1-3

    Topics: Analgesics, Opioid; Animals; Autoradiography; Conditioning, Operant; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Nicotine; Nicotinic Agonists; Receptors, Opioid, mu

2008
Interactions between Delta(9)-tetrahydrocannabinol and mu opioid receptor agonists in rhesus monkeys: discrimination and antinociception.
    Psychopharmacology, 2008, Volume: 199, Issue:2

    Topics: Analgesics; Analgesics, Opioid; Animals; Data Interpretation, Statistical; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Female; Heroin; Hot Temperature; Hypnotics and Sedatives; Macaca mulatta; Male; Midazolam; Morphine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Pain Measurement; Receptors, Opioid, mu; Substance Withdrawal Syndrome

2008
Mu-opioid receptor in the nucleus submedius: involvement in opioid-induced inhibition of mirror-image allodynia in a rat model of neuropathic pain.
    Neurochemical research, 2008, Volume: 33, Issue:10

    Topics: Animals; Behavior, Animal; Disease Models, Animal; Enkephalin, Leucine-2-Alanine; Hyperalgesia; Ligation; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Neuralgia; Oligopeptides; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Spinal Nerves; Thalamic Nuclei

2008
In vivo characterization of (-)(-)MCL-144 and (+)(-)MCL-193: isomeric, bivalent ligands with mu/kappa agonist properties.
    Neurochemical research, 2008, Volume: 33, Issue:10

    Topics: Alkanes; Analgesics; Animals; Brain; CHO Cells; Cricetinae; Cricetulus; Fumarates; Guanosine 5'-O-(3-Thiotriphosphate); Half-Life; Male; Morphinans; Morphine; Naltrexone; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stereoisomerism

2008
Morphine suppresses intracellular interferon-alpha expression in neuronal cells.
    Journal of neuroimmunology, 2008, Aug-13, Volume: 199, Issue:1-2

    Topics: Blotting, Western; Cell Line; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique; Gene Expression; Humans; Interferon-gamma; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Neurons; Promoter Regions, Genetic; Receptors, Opioid, mu; Reverse Transcriptase Polymerase Chain Reaction; STAT1 Transcription Factor; Transfection

2008
Inhibition of the development of morphine tolerance by a potent dual mu-delta-opioid antagonist, H-Dmt-Tic-Lys-NH-CH2-Ph.
    Pharmacology, biochemistry, and behavior, 2008, Volume: 90, Issue:4

    Topics: Analgesics, Opioid; Animals; Area Under Curve; Dose-Response Relationship, Drug; Drug Tolerance; Injections, Intraventricular; Injections, Subcutaneous; Ligands; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Oligopeptides; Reaction Time; Receptors, Opioid, delta; Receptors, Opioid, mu; Somatostatin

2008
Differential responses to morphine-induced analgesia in the tail-flick test.
    Behavioural brain research, 2008, Dec-12, Volume: 194, Issue:2

    Topics: Analgesia; Analgesics, Opioid; Analysis of Variance; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Gene Expression Regulation; Male; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Pain Measurement; Periaqueductal Gray; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Time Factors

2008
Augmentation of morphine-induced sensitization but reduction in morphine tolerance and reward in delta-opioid receptor knockout mice.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2009, Volume: 34, Issue:4

    Topics: Animals; Conditioning, Psychological; Drug Tolerance; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Reward; Spatial Behavior

2009
Crucial role of peripheral kappa-opioid receptors in a model of periodontal disease in rats.
    Journal of periodontal research, 2008, Volume: 43, Issue:6

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Chronic Periodontitis; Disease Models, Animal; Male; Morphine; Naltrexone; Narcotic Antagonists; Peripheral Nervous System; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa

2008
Hyaluronan-tethered opioid depots: synthetic strategies and release kinetics in vitro and in vivo.
    Bioconjugate chemistry, 2008, Volume: 19, Issue:9

    Topics: Analgesics, Opioid; Animals; Buffers; Drug Delivery Systems; Esterases; Esters; Half-Life; Hyaluronic Acid; Hydrolysis; Kinetics; Male; Mass Spectrometry; Morphine; Naltrexone; Rats; Rats, Sprague-Dawley

2008
Antagonist-precipitated and discontinuation-induced withdrawal in morphine-dependent rhesus monkeys.
    Psychopharmacology, 2008, Volume: 201, Issue:3

    Topics: Animals; Behavior, Animal; Body Temperature; Circadian Rhythm; Conditioning, Operant; Discrimination Learning; Drug Administration Schedule; Female; Heart Rate; Humans; Injections, Subcutaneous; Macaca mulatta; Morphine; Morphine Dependence; Motor Activity; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Sodium Chloride; Stereotyped Behavior; Substance Withdrawal Syndrome; Time Factors

2008
Narp regulates long-term aversive effects of morphine withdrawal.
    Behavioral neuroscience, 2008, Volume: 122, Issue:4

    Topics: Amygdala; Animals; Avoidance Learning; Behavior, Animal; C-Reactive Protein; Conditioning, Operant; Disease Models, Animal; Extinction, Psychological; Female; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Nerve Tissue Proteins; Retention, Psychology; Septal Nuclei; Substance Withdrawal Syndrome

2008
Morphine attenuates the expression of sensitization to ethanol, but opioid antagonists do not.
    Neuroscience, 2008, Oct-28, Volume: 156, Issue:4

    Topics: Analgesics, Opioid; Analysis of Variance; Animals; Autoradiography; Behavior, Animal; Brain; Central Nervous System Depressants; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Ethanol; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Protein Binding; Rats; Rats, Wistar; Tritium

2008
Differential effect of morphine and morphine-6-glucuronide on the control of breathing in the anesthetized cat.
    Anesthesiology, 2008, Volume: 109, Issue:4

    Topics: Analgesics, Opioid; Anesthesia; Animals; Blood-Brain Barrier; Carbon Dioxide; Cats; Female; Male; Morphine; Morphine Derivatives; Naltrexone; Respiration

2008
Antinociceptive action of 4-methyl-5-trifluoromethyl-5-hydroxy-4, 5-dihydro-1H-pyrazole methyl ester in models of inflammatory pain in mice.
    Life sciences, 2008, Nov-21, Volume: 83, Issue:21-22

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Dipyrone; Freund's Adjuvant; Indomethacin; Inflammation; Male; Mice; Morphine; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Pain, Postoperative; Postural Balance; Pyrazoles; Stomach Ulcer

2008
M5 muscarinic receptor knockout mice show reduced morphine-induced locomotion but increased locomotion after cholinergic antagonism in the ventral tegmental area.
    The Journal of pharmacology and experimental therapeutics, 2009, Volume: 328, Issue:1

    Topics: Animals; Atropine; Cholinergic Antagonists; Crosses, Genetic; Homozygote; Locomotion; Mecamylamine; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Knockout; Morphine; Motor Activity; Naltrexone; Receptor, Muscarinic M5; Ventral Tegmental Area

2009
Strain-specific differences in modulatory effects of morphine on peritoneal inflammation in mice.
    Folia biologica, 2005, Volume: 53, Issue:3-4

    Topics: Animals; Dose-Response Relationship, Drug; Leukocytes; Male; Mice; Mice, Inbred Strains; Morphine; Naltrexone; Peritonitis; Zymosan

2005
Open elevated plus maze-induced antinociception in rats: a non-opioid type of pain inhibition?
    Physiology & behavior, 2009, Mar-02, Volume: 96, Issue:3

    Topics: Adaptation, Physiological; Adrenalectomy; Analgesics, Opioid; Analysis of Variance; Animals; Drug Tolerance; Habituation, Psychophysiologic; Inhibition, Psychological; Male; Maze Learning; Morphine; Naltrexone; Narcotic Antagonists; Pain; Pain Threshold; Rats; Stress, Psychological

2009
Tolerance to the anticonvulsant effect of morphine in mice: blockage by ultra-low dose naltrexone.
    Epilepsy research, 2009, Volume: 83, Issue:2-3

    Topics: Analgesics, Opioid; Analysis of Variance; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Tolerance; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Pentylenetetrazole; Seizures

2009
FDA panel debates merits of next-generation opioid formulations.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2009, Jan-01, Volume: 66, Issue:1

    Topics: Analgesics, Opioid; Delayed-Action Preparations; Drug Approval; Humans; Morphine; Naltrexone; Oxycodone; United States; United States Food and Drug Administration

2009
Validation of a novel social investigation task that may dissociate social motivation from exploratory activity.
    Behavioural brain research, 2009, May-16, Volume: 199, Issue:2

    Topics: Amphetamine; Animals; Circadian Rhythm; Exploratory Behavior; Female; Haloperidol; Lighting; Male; Morphine; Motivation; Naltrexone; Psychological Tests; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Social Behavior

2009
Evidence for the involvement of the opioid system in the antidepressant-like effect of folic acid in the mouse forced swimming test.
    Behavioural brain research, 2009, Jun-08, Volume: 200, Issue:1

    Topics: Analgesics, Opioid; Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Disease Models, Animal; Dizocilpine Maleate; Drug Combinations; Excitatory Amino Acid Antagonists; Exploratory Behavior; Folic Acid; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Swimming

2009
The analgesic actions of centrally administered celecoxib are mediated by endogenous opioids.
    Pain, 2009, Volume: 142, Issue:1-2

    Topics: Analgesics, Opioid; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Celecoxib; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Administration Schedule; Drug Interactions; Enzyme Inhibitors; Immunologic Factors; Inflammation; Injections, Intraventricular; Leucine; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Pain Threshold; Pyrazoles; Rats; Reaction Time; Sulfonamides; Time Factors

2009
Neutral antagonist activity of naltrexone and 6beta-naltrexol in naïve and opioid-dependent C6 cells expressing a mu-opioid receptor.
    British journal of pharmacology, 2009, Volume: 156, Issue:7

    Topics: Adenylyl Cyclases; Animals; Binding, Competitive; Cell Line; Cell Line, Tumor; Cyclic AMP; Drug Inverse Agonism; Drug Partial Agonism; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Humans; Morphine; Naloxone; Naltrexone; Peptide Fragments; Piperidines; Radioligand Assay; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Somatostatin

2009
Inhibitory effect of low-dose pentazocine on the development of antinociceptive tolerance to morphine.
    Journal of anesthesia, 2009, Volume: 23, Issue:1

    Topics: Analgesics, Opioid; Animals; Cinnamates; Dose-Response Relationship, Drug; Drug Tolerance; Male; Mice; Mice, Inbred ICR; Morphine; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Pain Measurement; Pentazocine; Pressure; Receptors, Opioid, kappa

2009
Mu-opioid receptor redistribution in the locus coeruleus upon precipitation of withdrawal in opiate-dependent rats.
    Anatomical record (Hoboken, N.J. : 2007), 2009, Volume: 292, Issue:3

    Topics: Analgesics, Opioid; Animals; Fluorescent Antibody Technique; Immunoenzyme Techniques; Locus Coeruleus; Male; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Substance Withdrawal Syndrome

2009
Involvement of exon 11-associated variants of the mu opioid receptor MOR-1 in heroin, but not morphine, actions.
    Proceedings of the National Academy of Sciences of the United States of America, 2009, Mar-24, Volume: 106, Issue:12

    Topics: Alternative Splicing; Analgesia; Animals; Exons; Gastrointestinal Transit; Gene Targeting; Heroin; Heterozygote; Mice; Mice, Knockout; Morphine; Mutation; Naloxone; Naltrexone; Receptors, Opioid, mu

2009
Scratching behavior and Fos expression in superficial dorsal horn elicited by protease-activated receptor agonists and other itch mediators in mice.
    The Journal of pharmacology and experimental therapeutics, 2009, Volume: 329, Issue:3

    Topics: Animals; Behavior, Animal; Capsaicin; Histamine; Injections, Intradermal; Mice; Morphine; Naltrexone; Oligopeptides; Posterior Horn Cells; Proto-Oncogene Proteins c-fos; Pruritus; Receptor, PAR-2; Receptors, Opioid, mu; Receptors, Proteinase-Activated; Serotonin; Spinal Cord; Tachyphylaxis

2009
Shadows across mu-Star? Constitutively active mu-opioid receptors revisited.
    British journal of pharmacology, 2009, Volume: 156, Issue:7

    Topics: Adenylyl Cyclases; Animals; Binding, Competitive; Cell Line; Cell Line, Tumor; Drug Inverse Agonism; Drug Partial Agonism; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Humans; Morphine; Naltrexone; Radioligand Assay; Rats; Receptors, Opioid, mu

2009
Route of administration influences substitution patterns in rats trained to discriminate methadone vs. vehicle.
    Drug and alcohol dependence, 2009, Aug-01, Volume: 103, Issue:3

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Choice Behavior; Conditioning, Operant; Discrimination, Psychological; Heroin; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Methadone; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Pharmaceutical Vehicles; Rats; Rats, Sprague-Dawley; Stereoisomerism

2009
Naltrexone fails to increase pain affect in response to inflammatory pain in a novel escape/avoidance paradigm.
    Physiology & behavior, 2009, Sep-07, Volume: 98, Issue:3

    Topics: Animals; Avoidance Learning; Carrageenan; Dose-Response Relationship, Drug; Drug Interactions; Inflammation; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Pain Threshold; Random Allocation; Rats; Rats, Sprague-Dawley

2009
The unconditioned fear produced by morphine withdrawal is regulated by mu- and kappa-opioid receptors in the midbrain tectum.
    Behavioural brain research, 2009, Dec-01, Volume: 204, Issue:1

    Topics: Analgesics, Opioid; Animals; Catheterization; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Escape Reaction; Fear; Freezing Reaction, Cataleptic; Male; Microinjections; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid, kappa; Receptors, Opioid, mu; Substance Withdrawal Syndrome; Tectum Mesencephali

2009
Withania somnifera prevents morphine withdrawal-induced decrease in spine density in nucleus accumbens shell of rats: a confocal laser scanning microscopy study.
    Neurotoxicity research, 2009, Volume: 16, Issue:4

    Topics: Analysis of Variance; Animals; Behavior, Animal; Chromatography, High Pressure Liquid; Dendritic Spines; Disease Models, Animal; Male; Microscopy, Confocal; Morphine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Neurons; Nucleus Accumbens; Phytotherapy; Plant Extracts; Rats; Rats, Sprague-Dawley; Silver Staining; Substance Withdrawal Syndrome; Time Factors; Withania

2009
The antinociceptive properties of reboxetine in acute pain.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2009, Volume: 19, Issue:10

    Topics: Adrenergic Antagonists; Analgesics; Animals; Antidepressive Agents; Clonidine; Disease Models, Animal; Drug Interactions; Male; Mice; Mice, Inbred ICR; Morphine; Morpholines; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Reboxetine; Receptors, Opioid, mu

2009
Lack of effect of naltrindole on the spinal synergism of morphine and non-steroidal anti-inflammatory drugs (NSAIDS).
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2009, Volume: 60, Issue:2

    Topics: Analgesics, Opioid; Animals; Cyclooxygenase Inhibitors; Drug Synergism; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Morphine; Naltrexone; Pain; Receptors, Opioid, delta; Spinal Cord

2009
Regional Fos expression induced by morphine withdrawal in the 7-day-old rat.
    Developmental psychobiology, 2009, Volume: 51, Issue:7

    Topics: Analysis of Variance; Animals; Animals, Newborn; Cell Count; Female; Immunohistochemistry; Locus Coeruleus; Male; Morphine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Narcotics; Nucleus Accumbens; Periaqueductal Gray; Pregnancy; Proto-Oncogene Proteins c-fos; Rats; Rats, Long-Evans; Spinal Cord; Substance Withdrawal Syndrome

2009
Possible involvement of the hypothalamic pro-opiomelanocortin gene and beta-endorphin expression on acute morphine withdrawal development.
    Brain research bulletin, 2009, Dec-16, Volume: 80, Issue:6

    Topics: Animals; Arcuate Nucleus of Hypothalamus; Baclofen; beta-Endorphin; Dose-Response Relationship, Drug; GABA Agonists; Gene Expression; Hypothalamus; Male; Mice; Mice, Inbred ICR; Morphine; Muscimol; Naltrexone; Narcotic Antagonists; Narcotics; Pro-Opiomelanocortin; Substance Withdrawal Syndrome

2009
Evaluation of the tocolytic effect of morphine in a mouse model of lipopolysaccharide-induced preterm delivery: the role of nitric oxide.
    European journal of obstetrics, gynecology, and reproductive biology, 2009, Volume: 147, Issue:2

    Topics: Animals; Female; Lipopolysaccharides; Male; Mice; Morphine; Naltrexone; NG-Nitroarginine Methyl Ester; Nitric Oxide; Obstetric Labor, Premature; Placenta; Pregnancy; Tocolytic Agents

2009
Novel approach to demonstrate high efficacy of mu opioids in the rat vas deferens: a simple model of predictive value.
    Brain research bulletin, 2010, Jan-15, Volume: 81, Issue:1

    Topics: Analgesics, Opioid; Animals; Brain; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Male; Mice; Mice, Inbred Strains; Models, Biological; Morphine; Morphine Derivatives; Naltrexone; Oxymorphone; Pain; Rats; Rats, Wistar; Receptors, Opioid, mu; Vas Deferens

2010
Characteristics and comparative severity of respiratory response to toxic doses of fentanyl, methadone, morphine, and buprenorphine in rats.
    Toxicology letters, 2009, Dec-15, Volume: 191, Issue:2-3

    Topics: Animals; Blood Gas Analysis; Buprenorphine; Catheterization; Fentanyl; Lactic Acid; Male; Methadone; Morphine; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Narcotics; Plethysmography, Whole Body; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Respiratory Insufficiency; Respiratory Mechanics

2009
Acute methadone treatment reduces myocardial infarct size via the delta-opioid receptor in rats during reperfusion.
    Anesthesia and analgesia, 2009, Volume: 109, Issue:5

    Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Male; Methadone; Morphine; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Time Factors

2009
Long-lasting antinociceptive spinal effects in primates of the novel nociceptin/orphanin FQ receptor agonist UFP-112.
    Pain, 2010, Volume: 148, Issue:1

    Topics: Analgesics; Animals; Benzimidazoles; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hyperalgesia; Injections, Spinal; Macaca mulatta; Male; Morphine; Naltrexone; Nociceptin; Opioid Peptides; Pain Measurement; Pain Threshold; Piperidines

2010
Sex-specific mediation of opioid-induced hyperalgesia by the melanocortin-1 receptor.
    Anesthesiology, 2010, Volume: 112, Issue:1

    Topics: Analgesics, Opioid; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Female; Hyperalgesia; Infusions, Intravenous; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphine; Naltrexone; Narcotic Antagonists; Receptor, Melanocortin, Type 1; Receptors, N-Methyl-D-Aspartate; Sex Characteristics

2010
PRODUCT: Embeda 20mg/0.8mg.
    JAAPA : official journal of the American Academy of Physician Assistants, 2009, Volume: 22, Issue:11

    Topics: Analgesics, Opioid; Contraindications; Delayed-Action Preparations; Humans; Morphine; Naltrexone; Narcotic Antagonists; Osteoarthritis; Pain

2009
Mu-opioid receptors are not necessary for nortriptyline treatment of neuropathic allodynia.
    European journal of pain (London, England), 2010, Volume: 14, Issue:7

    Topics: Adrenergic Uptake Inhibitors; Analysis of Variance; Animals; Male; Mice; Mice, Knockout; Morphine; Naltrexone; Narcotic Antagonists; Neuralgia; Nortriptyline; Pain Measurement; Receptors, Opioid, mu

2010
Effects of kappa opioids in an assay of pain-depressed intracranial self-stimulation in rats.
    Psychopharmacology, 2010, Volume: 210, Issue:2

    Topics: Analgesics; Analgesics, Opioid; Animals; Benzeneacetamides; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Lactic Acid; Male; Medial Forebrain Bundle; Morphine; Naltrexone; Pain; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reinforcement, Psychology; Self Stimulation

2010
In vivo characterization of the opioid antagonist nalmefene in mice.
    Life sciences, 2010, Apr-10, Volume: 86, Issue:15-16

    Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Inhibitory Concentration 50; Male; Mice; Mice, Inbred ICR; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Pain; Substance Withdrawal Syndrome; Time Factors

2010
Severe opioid withdrawal due to misuse of new combined morphine and naltrexone product (Embeda).
    Annals of emergency medicine, 2010, Volume: 55, Issue:3

    Topics: Adult; Drug Combinations; Female; Humans; Morphine; Naltrexone; Patient Education as Topic; Substance Withdrawal Syndrome

2010
The involvement of micro-opioid receptors in the central nervous system in the worsening of allergic airway inflammation by psychological stress in mice.
    International archives of allergy and immunology, 2010, Volume: 152, Issue:4

    Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Central Nervous System; Cytokines; Disease Models, Animal; Female; Humans; Immunoglobulin E; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphine; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu; Stress, Psychological; Th2 Cells

2010
Evidence of central and peripheral sensitization in a rat model of narcotic bowel-like syndrome.
    Gastroenterology, 2010, Volume: 139, Issue:2

    Topics: Abdominal Pain; Animals; CD11b Antigen; Chymases; Colon; Delayed-Action Preparations; Disease Models, Animal; Gastrointestinal Transit; Hyperalgesia; Immunohistochemistry; Intestinal Mucosa; Male; Mast Cells; Microglia; Minocycline; Morphine; Naltrexone; Narcotic Antagonists; p38 Mitogen-Activated Protein Kinases; Pain Measurement; Pain Threshold; Pressure; Rats; Rats, Wistar; Spinal Cord; Syndrome; Thioxanthenes; Time Factors; Ubiquitin Thiolesterase; Xanthones

2010
Pretreatment time with norbinaltorphimine.
    Anesthesia and analgesia, 2010, Apr-01, Volume: 110, Issue:4

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Injections, Intraventricular; Injections, Spinal; Ischemic Preconditioning, Myocardial; Morphine; Naltrexone; Narcotic Antagonists; Rats; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu

2010
Ultra-low dose naltrexone attenuates chronic morphine-induced gliosis in rats.
    Molecular pain, 2010, Apr-16, Volume: 6

    Topics: Animals; Drug Tolerance; Gliosis; Imaging, Three-Dimensional; Immunohistochemistry; Male; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Spinal Cord

2010
New drug formulation treats chronic pain.
    The Nurse practitioner, 2010, Volume: 35, Issue:6

    Topics: Analgesics, Opioid; Chemistry, Pharmaceutical; Chronic Disease; Drug Combinations; Drug Therapy; Humans; Morphine; Naltrexone; Pain; Receptors, Opioid; Severity of Illness Index

2010
Investigation of Beckett-Casy model 2: synthesis of novel 15-16 nornaltrexone derivatives and their pharmacology.
    Bioorganic & medicinal chemistry letters, 2010, Jun-15, Volume: 20, Issue:12

    Topics: Electrons; Ethylenes; Hydrogen Bonding; Morphine; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Structure-Activity Relationship

2010
Disruption of morphine-conditioned place preference by a delta2-opioid receptor antagonist: study of mu-opioid and delta-opioid receptor expression at the synapse.
    The European journal of neuroscience, 2010, Volume: 32, Issue:4

    Topics: Analgesics, Opioid; Animals; Behavior, Animal; Conditioning, Classical; Male; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Subcellular Fractions; Synapses

2010
Spontaneous itch in the absence of hyperalgesia in a mouse hindpaw dry skin model.
    Neuroscience letters, 2010, Oct-22, Volume: 484, Issue:1

    Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Hindlimb; Hyperalgesia; Male; Mice; Morphine; Naltrexone; Pain Measurement; Pruritus; Skin

2010
Tolerance to the antinociceptive effect of morphine in the absence of short-term presynaptic desensitization in rat periaqueductal gray neurons.
    The Journal of pharmacology and experimental therapeutics, 2010, Volume: 335, Issue:3

    Topics: Analgesics; Animals; Drug Tolerance; Electrophysiological Phenomena; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Inhibitory Postsynaptic Potentials; Male; Morphine; Naltrexone; Neurons; Pain Measurement; Patch-Clamp Techniques; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid, mu; Signal Transduction

2010
Activation of phosphatidylinositol 3-kinase/Akt-mammalian target of Rapamycin signaling pathway in the hippocampus is essential for the acquisition of morphine-induced place preference in rats.
    Neuroscience, 2010, Nov-24, Volume: 171, Issue:1

    Topics: Animals; Chromones; Conditioning, Operant; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glial Fibrillary Acidic Protein; Hippocampus; Male; Morphine; Morpholines; Naltrexone; Narcotic Antagonists; Narcotics; Phosphatidylinositol 3-Kinases; Phosphopyruvate Hydratase; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction; Sirolimus; Statistics as Topic

2010
Dorsal hippocampal opioidergic system modulates anxiety-like behaviors in adult male Wistar rats.
    Psychiatry and clinical neurosciences, 2010, Volume: 64, Issue:6

    Topics: Analgesics, Opioid; Animals; Anxiety; CA1 Region, Hippocampal; Disease Models, Animal; Enkephalin, D-Penicillamine (2,5)-; Male; Maze Learning; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu

2010
Differential itch- and pain-related behavioral responses and µ-opoid modulation in mice.
    Acta dermato-venereologica, 2010, Volume: 90, Issue:6

    Topics: Analgesics, Opioid; Animals; Antigens, Plant; Behavior, Animal; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Histamine; Injections, Intradermal; Irritants; Male; Mice; Mice, Inbred ICR; Morphine; Motor Activity; Mucuna; Naltrexone; Narcotic Antagonists; Pain; Pruritus; Receptor, PAR-2; Receptors, Opioid, mu; Receptors, Thrombin; Time Factors

2010
The effect of morphine on orthodontic tooth movement in rats.
    Australian orthodontic journal, 2010, Volume: 26, Issue:2

    Topics: Analgesics, Opioid; Animals; Bone Resorption; Dental Alloys; Male; Maxilla; Molar; Morphine; Naltrexone; Narcotic Antagonists; Nickel; Orthodontic Wires; Osteoclasts; Random Allocation; Rats; Rats, Wistar; Root Resorption; Titanium; Tooth Apex; Tooth Cervix; Tooth Movement Techniques; Tooth Root

2010
Morphine postconditioning attenuates ICAM-1 expression on endothelial cells.
    Journal of Korean medical science, 2011, Volume: 26, Issue:2

    Topics: Animals; Benzophenanthridines; Endothelial Cells; Endothelium, Vascular; Humans; Intercellular Adhesion Molecule-1; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Protein Isoforms; Protein Kinase C; Receptors, Opioid; Reperfusion Injury; Signal Transduction; Umbilical Veins

2011
Morphine sensitization in the pentylenetetrazole-induced clonic seizure threshold in mice: role of nitric oxide and μ receptors.
    Epilepsy & behavior : E&B, 2011, Volume: 20, Issue:4

    Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pentylenetetrazole; Receptors, Opioid, mu; Seizures

2011
Ketanserin potentiates morphine-induced antinociception mediated by kappa-receptor activation.
    Pharmacological research, 2011, Volume: 64, Issue:1

    Topics: Adrenergic alpha-1 Receptor Antagonists; Analgesics; Animals; Dose-Response Relationship, Drug; Drug Synergism; Ketanserin; Male; Mice; Mice, Inbred Strains; Morphine; Naltrexone; Pain; Pain Measurement; Pain Threshold; Prazosin; Pyrrolidines; Receptors, Adrenergic, alpha-1; Receptors, Opioid, kappa; Receptors, Serotonin, 5-HT2; Serotonin Antagonists

2011
Sustained-release morphine sulfate with sequestered naltrexone for moderate to severe pain: a new opioid analgesic formulation and beyond.
    Expert opinion on pharmacotherapy, 2011, Volume: 12, Issue:7

    Topics: Analgesics, Opioid; Delayed-Action Preparations; Dosage Forms; Drug Combinations; Humans; Morphine; Naltrexone; Opioid-Related Disorders; Pain

2011
Dissociable effects of ultralow-dose naltrexone on tolerance to the antinociceptive and cataleptic effects of morphine.
    Behavioural pharmacology, 2011, Volume: 22, Issue:5-6

    Topics: Analgesics, Opioid; Animals; Catalepsy; Dose-Response Relationship, Drug; Drug Tolerance; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain; Rats; Rats, Long-Evans; Time Factors

2011
Involvement of neuropeptide FF receptors in neuroadaptive responses to acute and chronic opiate treatments.
    British journal of pharmacology, 2012, Volume: 165, Issue:2

    Topics: Adamantane; Analgesics, Opioid; Animals; Behavior, Animal; Conditioning, Classical; Dipeptides; Drug Tolerance; Fentanyl; Hot Temperature; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Pain; Receptors, Neuropeptide; Substance Withdrawal Syndrome

2012
Drug discrimination in pigeons trained to discriminate among morphine, U50488, a combination of these drugs, and saline.
    Behavioural pharmacology, 2011, Volume: 22, Issue:5-6

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Butorphanol; Columbidae; Discrimination Learning; Dose-Response Relationship, Drug; Ethylketocyclazocine; Male; Morphine; Naltrexone; Narcotic Antagonists; Pentazocine; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reinforcement Schedule; Sodium Chloride

2011
Neuroprotective potential of biphalin, multireceptor opioid peptide, against excitotoxic injury in hippocampal organotypic culture.
    Neurochemical research, 2011, Volume: 36, Issue:11

    Topics: Animals; Enkephalins; Excitatory Amino Acid Agents; Hippocampus; Morphine; N-Methylaspartate; Naltrexone; Narcotic Antagonists; Neuroprotective Agents; Organ Culture Techniques; Rats; Rats, Wistar; Receptors, Opioid, delta

2011
Opioidergic modulation of ethanol self-administration in the ventral pallidum.
    Alcoholism, clinical and experimental research, 2012, Volume: 36, Issue:2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Alcohol Drinking; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Globus Pallidus; Male; Microinjections; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Self Administration; Somatostatin

2012
Potentiation of brain stimulation reward by morphine: effects of neurokinin-1 receptor antagonism.
    Psychopharmacology, 2012, Volume: 220, Issue:1

    Topics: Analgesics, Opioid; Animals; Brain; Dose-Response Relationship, Drug; Electric Stimulation; Male; Mice; Mice, Inbred C57BL; Morphine; Naltrexone; Narcotic Antagonists; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Reinforcement, Psychology; Reward; Substance P

2012
Adverse events in the removal of naltrexone implants.
    Anaesthesia and intensive care, 2011, Volume: 39, Issue:5

    Topics: Adolescent; Adult; Analgesics, Opioid; Anesthesia Recovery Period; Anesthesia, Spinal; Anesthetics, General; Anesthetics, Local; Device Removal; Female; Humans; Incidence; Infections; Infusion Pumps, Implantable; Length of Stay; Male; Middle Aged; Morphine; Naltrexone; Narcotic Antagonists; Pain, Postoperative; Postoperative Complications; Retrospective Studies; Young Adult

2011
Reversal of morphine-induced urinary retention after methylnaltrexone.
    Archives of disease in childhood. Fetal and neonatal edition, 2012, Volume: 97, Issue:2

    Topics: Analgesics, Opioid; Humans; Infant, Newborn; Male; Morphine; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Ultrasonography; Urinary Retention

2012
Structural basis for μ-opioid receptor binding and activation.
    Structure (London, England : 1993), 2011, Nov-09, Volume: 19, Issue:11

    Topics: Amino Acid Substitution; Animals; Binding Sites; Binding, Competitive; Cattle; Cyclic AMP; Databases, Factual; Decapodiformes; Diprenorphine; Dose-Response Relationship, Drug; HEK293 Cells; Humans; Molecular Dynamics Simulation; Morphine; Mutagenesis, Site-Directed; Naltrexone; Protein Binding; Radioligand Assay; Receptors, Opioid, mu; Small Molecule Libraries

2011
YFa and analogs: investigation of opioid receptors in smooth muscle contraction.
    World journal of gastroenterology, 2011, Oct-28, Volume: 17, Issue:40

    Topics: Acetylcholine; Analgesics, Opioid; Animals; Cholinergic Agonists; Dynorphins; Enkephalin, Methionine; Guinea Pigs; Ileum; Male; Mice; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists; Neurotransmitter Agents; Oligopeptides; Receptors, Opioid; Vas Deferens

2011
Agonist-selective effects of opioid receptor ligands on cytosolic calcium concentration in rat striatal neurons.
    Drug and alcohol dependence, 2012, Jun-01, Volume: 123, Issue:1-3

    Topics: Animals; beta-Endorphin; Buprenorphine; Calcium; Corpus Striatum; Cytosol; Fluorescent Dyes; Fura-2; Ligands; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Opioid

2012
Mu opioid receptor activation modulates Toll like receptor 4 in murine macrophages.
    Brain, behavior, and immunity, 2012, Volume: 26, Issue:3

    Topics: Analgesics, Opioid; Animals; Cells, Cultured; Gene Expression; Immunosuppressive Agents; Macrophages, Peritoneal; Mice; Morphine; Naltrexone; Receptors, Opioid, mu; Toll-Like Receptor 4

2012
Opioid modulation of facial itch- and pain-related responses and grooming behavior in rats.
    Acta dermato-venereologica, 2012, Volume: 92, Issue:5

    Topics: Analgesics, Opioid; Animals; Antipruritics; Disease Models, Animal; Face; Grooming; Injections, Intradermal; Male; Morphine; Mustard Plant; Naltrexone; Narcotic Antagonists; Pain; Plant Oils; Pruritus; Rats; Rats, Sprague-Dawley; Serotonin; Time Factors

2012
The role of mu-opioid receptor signaling in the dorsolateral periaqueductal gray on conditional and unconditional responding to threatening and aversive stimuli.
    Neuroscience, 2012, Aug-02, Volume: 216

    Topics: Animals; Behavior, Animal; Conditioning, Psychological; Fear; Male; Morphine; Naltrexone; Narcotic Antagonists; Periaqueductal Gray; Rats; Rats, Long-Evans; Receptors, Opioid, mu; Signal Transduction

2012
The rewarding action of acute cocaine is reduced in β-endorphin deficient but not in μ opioid receptor knockout mice.
    European journal of pharmacology, 2012, Jul-05, Volume: 686, Issue:1-3

    Topics: Animals; Behavior, Animal; beta-Endorphin; Cocaine; Conditioning, Operant; Male; Mice; Mice, Knockout; Morphine; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu; Reward

2012
Supraspinal antinociceptive effect of apelin-13 in a mouse visceral pain model.
    Peptides, 2012, Volume: 37, Issue:1

    Topics: Acetic Acid; Analgesics; Analgesics, Opioid; Animals; Drug Synergism; Injections, Intraperitoneal; Injections, Intraventricular; Injections, Spinal; Intercellular Signaling Peptides and Proteins; Male; Mice; Morphine; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Nociception; Visceral Pain

2012
Differential development of antinociceptive tolerance to morphine and fentanyl is not linked to efficacy in the ventrolateral periaqueductal gray of the rat.
    The journal of pain, 2012, Volume: 13, Issue:8

    Topics: Analgesics, Opioid; Analysis of Variance; Animals; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Fentanyl; Male; Microinjections; Morphine; Naltrexone; Narcotic Antagonists; Pain Measurement; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Reaction Time

2012
Methylnaltrexone for opioid-induced constipation in a pediatric oncology patient.
    Journal of pain and symptom management, 2012, Volume: 44, Issue:1

    Topics: Analgesics, Opioid; Brain Neoplasms; Child; Constipation; Female; Humans; Morphine; Naltrexone; Narcotic Antagonists; Neuroblastoma; Pain; Quaternary Ammonium Compounds

2012
Characterization of 6α- and 6β-N-heterocyclic substituted naltrexamine derivatives as novel leads to development of mu opioid receptor selective antagonists.
    ACS chemical neuroscience, 2011, Jul-20, Volume: 2, Issue:7

    Topics: Animals; Caco-2 Cells; CHO Cells; Cricetinae; Cricetulus; Drug Implants; Guanosine 5'-O-(3-Thiotriphosphate); Heterocyclic Compounds; Humans; Male; Membranes; Mice; Morphine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Receptors, Opioid, mu; Substance Withdrawal Syndrome; Thalamus

2011
Antinociceptive properties of Micrurus lemniscatus venom.
    Toxicon : official journal of the International Society on Toxinology, 2012, Volume: 60, Issue:6

    Topics: Administration, Oral; Analgesics; Animals; Elapid Venoms; Elapidae; Male; Mice; Morphine; Naltrexone; Pain; Pain Measurement; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu

2012
Role of µ-opioid receptor reserve and µ-agonist efficacy as determinants of the effects of µ-agonists on intracranial self-stimulation in rats.
    Behavioural pharmacology, 2012, Volume: 23, Issue:7

    Topics: Animals; Brain; Drug Tolerance; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Reinforcement Schedule; Self Stimulation

2012
Pain-facilitating medullary neurons contribute to opioid-induced respiratory depression.
    Journal of neurophysiology, 2012, Volume: 108, Issue:9

    Topics: Analgesics, Opioid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Evoked Potentials; Male; Medulla Oblongata; Morphine; Naltrexone; Narcotic Antagonists; Neurons; Nociception; Nociceptive Pain; Rats; Rats, Sprague-Dawley; Respiratory Insufficiency

2012
Morphine induces hyperalgesia without involvement of μ-opioid receptor or morphine-3-glucuronide.
    Molecular medicine (Cambridge, Mass.), 2012, Dec-06, Volume: 18

    Topics: Animals; Hyperalgesia; Male; Mice; Morphine; Morphine Derivatives; Naltrexone; Reaction Time; Receptors, Opioid, mu

2012
Spinal cord stimulation reduces hypersensitivity through activation of opioid receptors in a frequency-dependent manner.
    European journal of pain (London, England), 2013, Volume: 17, Issue:4

    Topics: Analgesics, Opioid; Animals; Hyperalgesia; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Neuralgia; Pain Measurement; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Spinal Cord; Spinal Cord Stimulation

2013
The implications of tamper-resistant formulations for opioid rotation.
    Postgraduate medicine, 2012, Volume: 124, Issue:5

    Topics: Analgesics, Opioid; Chronic Pain; Delayed-Action Preparations; Drug Combinations; Drug Compounding; Drug Tolerance; Humans; Morphine; Naltrexone; Opioid-Related Disorders; Oxycodone; Oxymorphone; Patient Selection

2012
Involvement of peripheral cannabinoid and opioid receptors in β-caryophyllene-induced antinociception.
    European journal of pain (London, England), 2013, Volume: 17, Issue:5

    Topics: Animals; Cannabinoids; Endorphins; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Nociception; Pain; Pain Measurement; Polycyclic Sesquiterpenes; Receptor, Cannabinoid, CB2; Sesquiterpenes

2013
Antinociceptive effects of two deltorphins analogs in the tail-immersion test in rats.
    Peptides, 2013, Volume: 39

    Topics: Analgesics, Opioid; Animals; Drug Synergism; Drug Tolerance; Male; Morphine; Naltrexone; Narcotic Antagonists; Nociception; Oligopeptides; Pain Measurement; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa

2013
A non-rewarding, non-aversive buprenorphine/naltrexone combination attenuates drug-primed reinstatement to cocaine and morphine in rats in a conditioned place preference paradigm.
    Addiction biology, 2014, Volume: 19, Issue:4

    Topics: Animals; Behavior, Animal; Buprenorphine; Cocaine; Conditioning, Psychological; Cues; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Therapy, Combination; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Sprague-Dawley; Reward

2014
Maternally administered sustained-release naltrexone in rats affects offspring neurochemistry and behaviour in adulthood.
    PloS one, 2012, Volume: 7, Issue:12

    Topics: Animals; Behavior, Animal; Brain; Delayed-Action Preparations; Dynorphins; Enkephalins; Female; Gene Expression; Male; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Narcotics; Neostriatum; Pregnancy; Prenatal Exposure Delayed Effects; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Self Administration

2012
Effects of methylnaltrexone on guinea pig gastrointestinal motility.
    Naunyn-Schmiedeberg's archives of pharmacology, 2013, Volume: 386, Issue:4

    Topics: Animals; Gastrointestinal Motility; Gastrointestinal Tract; Guinea Pigs; Male; Morphine; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Receptors, Opioid, mu

2013
Increased agonist affinity at the μ-opioid receptor induced by prolonged agonist exposure.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013, Feb-27, Volume: 33, Issue:9

    Topics: Analgesics, Opioid; Analysis of Variance; Animals; Arrestin; Cell Membrane; Cells, Cultured; Dose-Response Relationship, Drug; Embryo, Mammalian; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Fibroblasts; Gene Expression; Guanosine 5'-O-(3-Thiotriphosphate); HEK293 Cells; Humans; Ligands; Mice; Mice, Knockout; Morphine; Naltrexone; Narcotic Antagonists; Opioid Peptides; Organic Chemicals; Pertussis Toxin; Pharmacological Phenomena; Protein Binding; Protein Conformation; Radioligand Assay; Receptors, Opioid, mu; Substrate Specificity; Time Factors; Transfection; Tritium

2013
Differential control of opioid antinociception to thermal stimuli in a knock-in mouse expressing regulator of G-protein signaling-insensitive Gαo protein.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013, Mar-06, Volume: 33, Issue:10

    Topics: Analgesics, Opioid; Animals; Brain; Diprenorphine; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Excitatory Amino Acid Antagonists; Female; GABA Antagonists; gamma-Aminobutyric Acid; Gene Expression Regulation; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine 5'-O-(3-Thiotriphosphate); Hot Temperature; Humans; Hyperalgesia; Inhibitory Postsynaptic Potentials; Isotopes; Male; Methadone; Mice; Mice, Transgenic; Morphine; Mutation; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Oligopeptides; Pain Measurement; Patch-Clamp Techniques; Pertussis Toxin; Protein Binding; Reaction Time; RGS Proteins; Signal Transduction; Spinal Cord

2013
Rewarding effects of ethanol combined with low doses of morphine through dopamine D1 receptors.
    Journal of Nippon Medical School = Nippon Ika Daigaku zasshi, 2013, Volume: 80, Issue:1

    Topics: Analgesics, Opioid; Animals; Benzazepines; Central Nervous System Depressants; Conditioning, Psychological; Dose-Response Relationship, Drug; Ethanol; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Reward

2013
Co-activation of μ- and δ-opioid receptors elicits tolerance to morphine-induced ventilatory depression via generation of peroxynitrite.
    Respiratory physiology & neurobiology, 2013, May-01, Volume: 186, Issue:3

    Topics: Analysis of Variance; Animals; Antidotes; Drug Tolerance; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Penicillamine; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Respiratory Insufficiency; Time Factors

2013
μ-opioid receptors in the stimulation of mesolimbic dopamine activity by ethanol and morphine in Long-Evans rats: a delayed effect of ethanol.
    Psychopharmacology, 2013, Volume: 228, Issue:3

    Topics: Animals; Dopamine; Dose-Response Relationship, Drug; Ethanol; Injections, Intravenous; Injections, Subcutaneous; Male; Microdialysis; Microinjections; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Long-Evans; Receptors, Opioid, mu; Time Factors; Ventral Tegmental Area

2013
The in vivo pharmacodynamics of the novel opioid receptor antagonist, TD-1211, in models of opioid-induced gastrointestinal and CNS activity.
    Naunyn-Schmiedeberg's archives of pharmacology, 2013, Volume: 386, Issue:6

    Topics: Administration, Oral; Analgesics, Opioid; Animals; Benzamides; Central Nervous System; Dogs; Female; Gastrointestinal Tract; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Pain; Piperidines; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Tropanes

2013
The interaction of adenosine and morphine on pentylenetetrazole-induced seizure threshold in mice.
    Neuropharmacology, 2013, Volume: 72

    Topics: Adenosine; Animals; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Pentylenetetrazole; Seizures; Xanthines

2013
Role of the endogenous opioid system in modulation of urinary bladder activity by spinal nerve stimulation.
    American journal of physiology. Renal physiology, 2013, Jul-01, Volume: 305, Issue:1

    Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Electric Stimulation; Female; Morphine; Muscle Contraction; Naltrexone; Narcotic Antagonists; Neural Inhibition; Opioid Peptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Spinal Nerves; Time Factors; Urinary Bladder; Urination

2013
Synthesis, modeling, and pharmacological evaluation of UMB 425, a mixed μ agonist/δ antagonist opioid analgesic with reduced tolerance liabilities.
    ACS chemical neuroscience, 2013, Sep-18, Volume: 4, Issue:9

    Topics: Analgesics, Opioid; Animals; CHO Cells; Computer Simulation; Cricetulus; Drug Evaluation, Preclinical; Drug Tolerance; Humans; Male; Mice; Models, Chemical; Molecular Structure; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptive Pain; Pain Measurement; Protein Binding; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship; Thebaine; Transfection

2013
Morphine treatment selectively regulates expression of rat pituitary POMC and the prohormone convertases PC1/3 and PC2.
    Peptides, 2013, Volume: 47

    Topics: Animals; Cyclic AMP Response Element-Binding Protein; Gene Expression Regulation; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Pituitary Gland; Pro-Opiomelanocortin; Proprotein Convertase 1; Proprotein Convertase 2; Rats; Rats, Sprague-Dawley; RNA, Messenger

2013
Pain-related depression of the mesolimbic dopamine system in rats: expression, blockade by analgesics, and role of endogenous κ-opioids.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2014, Volume: 39, Issue:3

    Topics: Analgesics, Opioid; Animals; Benzeneacetamides; Depression; Disease Models, Animal; Dopamine; Gene Expression Regulation; Ketoprofen; Lactic Acid; Male; Medial Forebrain Bundle; Morphine; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Pain; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Self Stimulation; Time Factors

2014
Impact of organic solvent additive on the integrity of plasma samples in bioanalysis by LC-MS/MS.
    Bioanalysis, 2013, Volume: 5, Issue:19

    Topics: Chromatography, High Pressure Liquid; Humans; Lipids; Morphine; Morphine Derivatives; Naltrexone; Organic Chemicals; Pharmaceutical Preparations; Quality Control; Reference Standards; Solvents; Tandem Mass Spectrometry

2013
Morphine intake and the effects of naltrexone and buprenorphine on the acquisition of methamphetamine intake.
    Genes, brain, and behavior, 2014, Volume: 13, Issue:2

    Topics: Amphetamine-Related Disorders; Animals; Buprenorphine; Choice Behavior; Female; Inbreeding; Male; Methamphetamine; Mice; Morphine; Naltrexone; Narcotic Antagonists; Selection, Genetic

2014
Antinociceptive activity of a synthetic oxopyrrolidine-based compound, ASH21374, and determination of its possible mechanisms.
    Canadian journal of physiology and pharmacology, 2013, Volume: 91, Issue:12

    Topics: Analgesics; Analgesics, Opioid; Animals; Aspirin; Capsaicin; Cyclic GMP; Glutamic Acid; Male; Mice; Mice, Inbred BALB C; Morphine; Motor Activity; Naloxone; Naltrexone; Nitric Oxide; Pyrrolidines; Rats, Sprague-Dawley; Receptors, Opioid

2013
Opioid analgesics stop the development of clostridial gas gangrene.
    The Journal of infectious diseases, 2014, Aug-01, Volume: 210, Issue:3

    Topics: Analgesics, Opioid; Animals; Buprenorphine; Clostridium perfringens; Female; Gas Gangrene; Mice; Mice, Inbred BALB C; Morphine; Naltrexone

2014
C-Fos activation in the periaqueductal gray following acute morphine-3β-D-glucuronide or morphine administration.
    Physiology & behavior, 2014, May-10, Volume: 130

    Topics: Animals; Central Nervous System Stimulants; Hyperalgesia; Immunohistochemistry; Male; Mice, Inbred Strains; Microscopy, Confocal; Morphine; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Narcotics; Neurons; Pain Threshold; Periaqueductal Gray; Proto-Oncogene Proteins c-fos; Random Allocation

2014
Opioid/NMDA receptors blockade reverses the depressant-like behavior of foot shock stress in the mouse forced swimming test.
    European journal of pharmacology, 2014, Jul-15, Volume: 735

    Topics: Analgesics, Opioid; Animals; Behavior, Animal; Depression; Dizocilpine Maleate; Electroshock; Foot; Male; Mice; Morphine; Motor Activity; N-Methylaspartate; Naltrexone; Narcotic Antagonists; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Stress, Psychological; Swimming

2014
Prolonged morphine treatment alters δ opioid receptor post-internalization trafficking.
    British journal of pharmacology, 2015, Volume: 172, Issue:2

    Topics: Analgesics, Opioid; Animals; Benzamides; Cells, Cultured; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Ganglia, Spinal; Male; Mice, Knockout; Morphine; Naltrexone; Neurons; Oligopeptides; Piperazines; Protein Transport; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu

2015
Effect of naltrexone on neuropathic pain in mice locally transfected with the mutant μ-opioid receptor gene in spinal cord.
    British journal of pharmacology, 2015, Volume: 172, Issue:2

    Topics: Analgesics; Animals; Conditioning, Psychological; Genetic Vectors; HEK293 Cells; Humans; Lentivirus; Male; Mice, Inbred C57BL; Morphine; Mutation; Naltrexone; Narcotic Antagonists; Neuralgia; Receptors, Opioid, mu; Reward; Spinal Cord; Spinal Nerves; Substance Withdrawal Syndrome; Transfection

2015
Operant nociception in nonhuman primates.
    Pain, 2014, Volume: 155, Issue:9

    Topics: Analgesics, Opioid; Animals; Conditioning, Operant; Hot Temperature; Male; Morphine; Naltrexone; Nociception; Pain; Pain Measurement; Pain Threshold; Saimiri

2014
The opioid receptor pharmacology of GSK1521498 compared to other ligands with differential effects on compulsive reward-related behaviours.
    Psychopharmacology, 2015, Volume: 232, Issue:1

    Topics: Analgesics, Opioid; Animals; CHO Cells; Compulsive Behavior; Cricetinae; Cricetulus; Guanosine 5'-O-(3-Thiotriphosphate); HEK293 Cells; Humans; Indans; Ligands; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Protein Binding; Receptors, Opioid, mu; Reward; Treatment Outcome; Triazoles

2015
Epigenetic regulation of spinal cord gene expression controls opioid-induced hyperalgesia.
    Molecular pain, 2014, Sep-12, Volume: 10

    Topics: Analgesics, Opioid; Animals; Antineoplastic Agents; Azepines; Benzamides; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Dynorphins; Epigenesis, Genetic; Gene Expression Regulation; Hydroxamic Acids; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Morphine; Naltrexone; Narcotic Antagonists; Pain Measurement; Spinal Cord; Vorinostat

2014
Sustained pain-related depression of behavior: effects of intraplantar formalin and complete freund's adjuvant on intracranial self-stimulation (ICSS) and endogenous kappa opioid biomarkers in rats.
    Molecular pain, 2014, Sep-23, Volume: 10

    Topics: Analgesics, Opioid; Animals; Body Weight; Conditioning, Operant; Disease Models, Animal; Formaldehyde; Freund's Adjuvant; Hyperalgesia; Inhibition, Psychological; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Self Stimulation

2014
Downregulation of spinal endomorphin-2 correlates with mechanical allodynia in a rat model of tibia cancer.
    Neuroscience, 2015, Feb-12, Volume: 286

    Topics: Analgesics; Animals; Bone Neoplasms; Disease Models, Animal; Down-Regulation; Female; Hyperalgesia; Morphine; Naltrexone; Narcotic Antagonists; Oligopeptides; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Tibia

2015
The kappa-opioid receptor antagonist, nor-binaltorphimine (nor-BNI), decreases morphine withdrawal and the consequent conditioned place aversion in rats.
    Behavioural brain research, 2015, Apr-15, Volume: 283

    Topics: Animals; Conditioning, Psychological; Defecation; Dynorphins; Male; Morphine; Morphine Dependence; Motor Activity; Naltrexone; Narcotic Antagonists; Narcotics; Neurotransmitter Agents; Random Allocation; Rats, Long-Evans; Receptors, Opioid, kappa; Spatial Behavior; Substance Withdrawal Syndrome

2015
Implication of delta opioid receptor subtype 2 but not delta opioid receptor subtype 1 in the development of morphine analgesic tolerance in a rat model of chronic inflammatory pain.
    The European journal of neuroscience, 2015, Volume: 41, Issue:7

    Topics: Analgesics, Opioid; Animals; Benzylidene Compounds; Chronic Pain; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Tolerance; Freund's Adjuvant; Hindlimb; Inflammation; Male; Morphine; Naltrexone; Narcotic Antagonists; Rats, Sprague-Dawley; Receptors, Opioid, delta

2015
Low-dose naltrexone to prevent intolerable morphine adverse events: a forgotten remedy for a neglected, global clinical need.
    Pain medicine (Malden, Mass.), 2015, Volume: 16, Issue:6

    Topics: Analgesics, Opioid; Chronic Pain; Dose-Response Relationship, Drug; Humans; Morphine; Naltrexone; Narcotic Antagonists; Neoplasms

2015
Enkephalin analog, cyclo[N(ε),N(β)-carbonyl-D-Lys(2),Dap(5)] enkephalinamide (cUENK6), inhibits the ethanol withdrawal-induced anxiety-like behavior in rats.
    Alcohol (Fayetteville, N.Y.), 2015, Volume: 49, Issue:3

    Topics: Analgesics, Opioid; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Central Nervous System Depressants; Enkephalin, Leucine; Enkephalins; Ethanol; Morphine; Naltrexone; Narcotic Antagonists; Neurotransmitter Agents; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Substance Withdrawal Syndrome

2015
Chorionic morphine, naltrexone and pentoxifylline effect on hypophyso-gonadal hormones of male rats.
    Bratislavske lekarske listy, 2015, Volume: 116, Issue:4

    Topics: Animals; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Gonadotropins, Pituitary; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Pentoxifylline; Phosphodiesterase Inhibitors; Rats; Rats, Wistar; Reproduction; Substance-Related Disorders; Testosterone

2015
High-dose pentazocine antagonizes the antinociception induced by high-dose morphine.
    Life sciences, 2015, Jun-01, Volume: 130

    Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred C57BL; Morphine; Naltrexone; Pain; Pentazocine; Receptors, Opioid, kappa

2015
Rutin antinociception involves opioidergic mechanism and descending modulation of ventrolateral periaqueductal grey matter in rats.
    European journal of pain (London, England), 2016, Volume: 20, Issue:2

    Topics: Animals; Male; Microinjections; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Nociception; Pain; Pain Measurement; Periaqueductal Gray; Rats; Rats, Wistar; Receptors, Opioid; Rutin; Tramadol

2016
Behavioral and neurochemical analysis of ongoing bone cancer pain in rats.
    Pain, 2015, Volume: 156, Issue:10

    Topics: Adenocarcinoma; Analgesics, Opioid; Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Bone Neoplasms; Cell Line, Tumor; Diclofenac; Disease Models, Animal; Female; Gyrus Cinguli; Lidocaine; Morphine; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Pain; Rats; Rats, Inbred F344

2015
Spinal and supraspinal N-methyl-D-aspartate and melanocortin-1 receptors contribute to a qualitative sex difference in morphine-induced hyperalgesia.
    Physiology & behavior, 2015, Aug-01, Volume: 147

    Topics: Analgesics, Opioid; Animals; Brain Stem; Dose-Response Relationship, Drug; Drug Administration Routes; Female; Hyperalgesia; Male; Mice; Morphine; Naltrexone; Ovariectomy; Pain Measurement; Progesterone; Progestins; Reaction Time; Receptor, Melanocortin, Type 1; Receptors, N-Methyl-D-Aspartate; Sex Characteristics; Spinal Cord

2015
Structure-Activity Relationships of (+)-Naltrexone-Inspired Toll-like Receptor 4 (TLR4) Antagonists.
    Journal of medicinal chemistry, 2015, Jun-25, Volume: 58, Issue:12

    Topics: Analgesics, Opioid; Animals; Cell Line; Drug Synergism; Humans; Lipopolysaccharides; Male; Microglia; Morphinans; Morphine; Naltrexone; Nitric Oxide; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Toll-Like Receptor 4

2015
Mediation of opioid analgesia by a truncated 6-transmembrane GPCR.
    The Journal of clinical investigation, 2015, Jul-01, Volume: 125, Issue:7

    Topics: Alternative Splicing; Analgesics, Opioid; Animals; Exons; Gene Targeting; Methadone; Mice; Mice, Knockout; Morphine; Naltrexone; Pain; Peptide Fragments; Protein Structure, Tertiary; Receptors, Opioid, mu; Recombinant Proteins

2015
Development and validation of a bioanalytical method for the simultaneous determination of heroin, its main metabolites, naloxone and naltrexone by LC-MS/MS in human plasma samples: Application to a clinical trial of oral administration of a heroin/naloxo
    Journal of pharmaceutical and biomedical analysis, 2015, Oct-10, Volume: 114

    Topics: Administration, Oral; Calibration; Chromatography, Liquid; Codeine; Formates; Healthy Volunteers; Heroin; Humans; Hydrogen-Ion Concentration; Limit of Detection; Morphine; Naloxone; Naltrexone; Quality Control; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Substance Abuse Detection; Tandem Mass Spectrometry

2015
Antagonism of κ opioid receptor in the nucleus accumbens prevents the depressive-like behaviors following prolonged morphine abstinence.
    Behavioural brain research, 2015, Sep-15, Volume: 291

    Topics: Animals; Antidepressive Agents; Depressive Disorder; Disease Models, Animal; Dose-Response Relationship, Drug; Enkephalins; Male; Mice, Inbred C57BL; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Narcotics; Nucleus Accumbens; Protein Precursors; Receptors, Opioid, kappa; RNA, Messenger; Substance Withdrawal Syndrome

2015
Morphine Modulates Interleukin-4- or Breast Cancer Cell-induced Pro-metastatic Activation of Macrophages.
    Scientific reports, 2015, Jun-16, Volume: 5

    Topics: Animals; Arginase; Bone Marrow Cells; Cell Differentiation; Cell Line; Cell Line, Tumor; Cell Movement; Coculture Techniques; Female; Gene Expression Regulation, Neoplastic; Humans; Interleukin-4; Macrophage Activation; Macrophages; Mammary Glands, Animal; Matrix Metalloproteinase 9; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Morphine; Naloxone; Naltrexone; Quaternary Ammonium Compounds; Receptors, Cell Surface; Receptors, Immunologic; Signal Transduction

2015
Technology: Barriers to misuse.
    Nature, 2015, Jun-25, Volume: 522, Issue:7557

    Topics: Analgesics, Opioid; Chemistry, Pharmaceutical; Drug Combinations; Drug Overdose; Drug Users; Humans; Morphine; Naltrexone; Opioid-Related Disorders; Oxycodone; Prodrugs

2015
Morphine modulates the effects of histamine H1 and H3 receptors on seizure susceptibility in pentylenetetrazole-induced seizure model of mice.
    European journal of pharmacology, 2015, Dec-15, Volume: 769

    Topics: Animals; Disease Models, Animal; Disease Susceptibility; Dose-Response Relationship, Drug; Histamine Agonists; Histamine Antagonists; Male; Mice; Morphine; Naltrexone; Pentylenetetrazole; Receptors, Histamine H1; Receptors, Histamine H3; Seizures

2015
Differences in the morphine-induced inhibition of small and large intestinal transit: Involvement of central and peripheral μ-opioid receptors in mice.
    European journal of pharmacology, 2016, Jan-15, Volume: 771

    Topics: Analgesics, Opioid; Animals; Central Nervous System; Dose-Response Relationship, Drug; Gastrointestinal Transit; Injections, Intraventricular; Intestine, Large; Intestine, Small; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Peripheral Nervous System; Receptors, Opioid, mu

2016
A stability-indicating HPLC method for simultaneous determination of morphine and naltrexone.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2016, Feb-01, Volume: 1011

    Topics: Chromatography, High Pressure Liquid; Drug Stability; Linear Models; Morphine; Naltrexone; Reproducibility of Results; Sensitivity and Specificity

2016
Cannabidiol disrupts the reconsolidation of contextual drug-associated memories in Wistar rats.
    Addiction biology, 2017, Volume: 22, Issue:3

    Topics: Animals; Cannabidiol; Cocaine; Conditioning, Classical; Cues; Disease Models, Animal; Male; Memory; Mental Recall; Morphine; Naltrexone; Rats; Rats, Wistar; Reward

2017
The interaction between morphine and propranolol in chemical and electrical seizure models of mice.
    Neurological research, 2016, Volume: 38, Issue:2

    Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Administration Schedule; Drug Interactions; Electroshock; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Pentylenetetrazole; Propranolol; Seizures; Time Factors

2016
Methylnaltrexone for the Treatment of Constipation in Critically Ill Children.
    Journal of clinical gastroenterology, 2016, Volume: 50, Issue:4

    Topics: Abdominal Pain; Analgesics, Opioid; Child; Constipation; Critical Illness; Defecation; Humans; Infant; Laxatives; Male; Morphine; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Treatment Outcome

2016
Truncated mu opioid GPCR variant involvement in opioid-dependent and opioid-independent pain modulatory systems within the CNS.
    Proceedings of the National Academy of Sciences of the United States of America, 2016, Mar-29, Volume: 113, Issue:13

    Topics: Alternative Splicing; Analgesia; Analgesics, Opioid; Animals; Female; Humans; Male; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Morphine; Naltrexone; Pain Management; Pain Measurement; Protein Isoforms; Protein Structure, Tertiary; Receptors, Opioid, mu

2016
Preferential Delivery of an Opioid Antagonist to the Fetal Brain in Pregnant Mice.
    The Journal of pharmacology and experimental therapeutics, 2016, Volume: 358, Issue:1

    Topics: Animals; Behavior, Animal; Brain; Dose-Response Relationship, Drug; Female; Mice, Inbred C57BL; Morphine; Naltrexone; Narcotic Antagonists; Placenta; Pregnancy; Substance Withdrawal Syndrome; Tissue Distribution

2016
Enhancement of Cisplatin Nephrotoxicity by Morphine and Its Attenuation by the Opioid Antagonist Naltrexone.
    Acta medica Iranica, 2016, Volume: 54, Issue:7

    Topics: Acute Kidney Injury; Analgesics, Opioid; Animals; Antineoplastic Agents; Blood Urea Nitrogen; Cisplatin; Creatinine; Drug Synergism; Drug Therapy, Combination; Glutathione; Glutathione Peroxidase; Humans; Interleukin-1beta; Kidney; Male; Morphine; Naltrexone; Narcotic Antagonists; Rats; Superoxide Dismutase; Tumor Necrosis Factor-alpha

2016
Study on the molecular mechanism of antinociception induced by ghrelin in acute pain in mice.
    Peptides, 2016, Volume: 83

    Topics: Acute Pain; Analgesics; Animals; Ghrelin; Humans; Male; Mice; Morphine; Naltrexone; Oligopeptides; Receptors, Ghrelin; Receptors, Opioid, delta

2016
Rearing environment differentially modulates cocaine self-administration after opioid pretreatment: A behavioral economic analysis.
    Drug and alcohol dependence, 2016, Oct-01, Volume: 167

    Topics: Analgesics, Opioid; Animals; Behavior, Animal; Cocaine; Economics, Behavioral; Environment; Male; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Self Administration; Substance-Related Disorders; Time Factors

2016
Morphine amplifies mechanical allodynia via TLR4 in a rat model of spinal cord injury.
    Brain, behavior, and immunity, 2016, Volume: 58

    Topics: Analgesics, Opioid; Animals; Hyperalgesia; Male; Morphine; Naltrexone; Neuralgia; Rats, Sprague-Dawley; Spinal Cord Injuries; Toll-Like Receptor 4

2016
Lithium attenuated the behavioral despair induced by acute neurogenic stress through blockade of opioid receptors in mice.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2016, Volume: 83

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Lithium; Male; Mice; Morphine; Naltrexone; Receptors, Opioid; Stress, Psychological; Swimming

2016
The µ-opioid system promotes visual attention to faces and eyes.
    Social cognitive and affective neuroscience, 2016, Volume: 11, Issue:12

    Topics: Adult; Analgesics, Opioid; Attention; Cues; Eye Movements; Face; Humans; Male; Morphine; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu; Reward; Social Behavior; Visual Perception; Young Adult

2016
Sweet taste pleasantness is modulated by morphine and naltrexone.
    Psychopharmacology, 2016, Volume: 233, Issue:21-22

    Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Double-Blind Method; Eating; Emotions; Food Preferences; Humans; Male; Morphine; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu; Sucrose; Sweetening Agents; Taste; Young Adult

2016
Nor-Binaltorphimine Blocks the Adverse Effects of Morphine after Spinal Cord Injury.
    Journal of neurotrauma, 2017, 03-15, Volume: 34, Issue:6

    Topics: Animals; Disease Models, Animal; Drug-Related Side Effects and Adverse Reactions; Male; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Narcotics; Nociception; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Recovery of Function; Spinal Cord Injuries

2017
Pentoxifylline besides naltrexone recovers morphine-induced inflammation in male reproductive system of rats by regulating Toll-like receptor pathway.
    Andrologia, 2017, Volume: 49, Issue:9

    Topics: Animals; Drug Evaluation, Preclinical; Genital Diseases, Male; Genitalia, Male; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Pentoxifylline; Phosphodiesterase Inhibitors; Rats, Wistar; Toll-Like Receptors

2017
Loss of μ opioid receptor signaling in nociceptors, but not microglia, abrogates morphine tolerance without disrupting analgesia.
    Nature medicine, 2017, Volume: 23, Issue:2

    Topics: Analgesia; Analgesics, Opioid; Animals; Chronic Pain; Disease Models, Animal; Drug Tolerance; Gene Deletion; Hyperalgesia; Long-Term Potentiation; Mice; Mice, Knockout; Microglia; Morphine; Naltrexone; Nociception; Nociceptors; Pain, Postoperative; Quaternary Ammonium Compounds; Receptors, Opioid, mu; Signal Transduction; Spinal Cord

2017
New opioid receptor antagonist: Naltrexone-14-O-sulfate synthesis and pharmacology.
    European journal of pharmacology, 2017, Aug-15, Volume: 809

    Topics: Analgesics; Animals; Behavior, Animal; Chemistry Techniques, Synthetic; Colon; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid; Vas Deferens

2017
Opioid system contribution to the antidepressant-like action of m-trifluoromethyl-diphenyl diselenide in mice: A compound devoid of tolerance and withdrawal syndrome.
    Journal of psychopharmacology (Oxford, England), 2017, Volume: 31, Issue:9

    Topics: Analgesics, Opioid; Animals; Antidepressive Agents; Behavior, Animal; Depression; Depressive Disorder; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Organosilicon Compounds; Receptors, Opioid, kappa; Substance Withdrawal Syndrome; Swimming

2017
Maintenance on naltrexone+amphetamine decreases cocaine-vs.-food choice in male rhesus monkeys.
    Drug and alcohol dependence, 2017, 12-01, Volume: 181

    Topics: Administration, Intravenous; Animals; Choice Behavior; Cocaine; Dextroamphetamine; Dose-Response Relationship, Drug; Drug Interactions; Food; Macaca mulatta; Male; Morphine; Naltrexone; Receptors, Opioid, mu; Reinforcement, Psychology; Self Administration

2017
Role of central versus peripheral opioid system in antinociceptive and anti-inflammatory effect of botulinum toxin type A in trigeminal region.
    European journal of pain (London, England), 2018, Volume: 22, Issue:3

    Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents; Botulinum Toxins, Type A; Dura Mater; Male; Migraine Disorders; Morphine; Naltrexone; Narcotic Antagonists; Neurogenic Inflammation; Neuromuscular Agents; Nociception; Pain; Pain Measurement; Quaternary Ammonium Compounds; Rats; Rats, Wistar; Sciatic Nerve; Trigeminal Caudal Nucleus; Trigeminal Nerve

2018
To probe interaction of morphine and IBNtxA with 7TM and 6TM variants of the human μ-opioid receptor using all-atom molecular dynamics simulations with an explicit membrane.
    Physical chemistry chemical physics : PCCP, 2018, Jan-17, Volume: 20, Issue:3

    Topics: Amino Acid Sequence; Animals; Binding Sites; Humans; Ligands; Mice; Molecular Dynamics Simulation; Morphine; Mutagenesis; Naltrexone; Protein Domains; Receptors, Opioid, mu; Sequence Alignment

2018
Lateralized kappa opioid receptor signaling from the amygdala central nucleus promotes stress-induced functional pain.
    Pain, 2018, Volume: 159, Issue:5

    Topics: Analgesics, Opioid; Animals; Capsaicin; Central Amygdaloid Nucleus; Dynorphins; Hypothalamus; Male; Medulla Oblongata; Morphine; Naltrexone; Narcotic Antagonists; Pain; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Stress, Physiological

2018
Morphine induces changes in the gut microbiome and metabolome in a morphine dependence model.
    Scientific reports, 2018, 02-26, Volume: 8, Issue:1

    Topics: Analgesics, Opioid; Analysis of Variance; Animals; Deoxycholic Acid; Disease Models, Animal; Drug Tolerance; Dysbiosis; Enterococcus faecalis; Female; Gastrointestinal Microbiome; Metabolome; Mice; Mice, Inbred C57BL; Morphine; Morphine Dependence; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Phosphatidylethanolamines; Statistics, Nonparametric

2018
Naltrexone maintenance fails to alter amphetamine effects on intracranial self-stimulation in rats.
    Experimental and clinical psychopharmacology, 2018, Volume: 26, Issue:2

    Topics: Amphetamine; Animals; Central Nervous System Stimulants; Cocaine; Deep Brain Stimulation; Dose-Response Relationship, Drug; Male; Medial Forebrain Bundle; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Sprague-Dawley; Self Stimulation; Substance-Related Disorders

2018
Abuse liability and therapeutic potential of the Mitragyna speciosa (kratom) alkaloids mitragynine and 7-hydroxymitragynine.
    Addiction biology, 2019, Volume: 24, Issue:5

    Topics: Analgesics, Opioid; Animals; Behavior, Animal; Mitragyna; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Secologanin Tryptamine Alkaloids; Self Administration

2019
Methylation Products of 6β- N-Heterocyclic Substituted Naltrexamine Derivatives as Potential Peripheral Opioid Receptor Modulators.
    ACS chemical neuroscience, 2018, 12-19, Volume: 9, Issue:12

    Topics: Analgesics, Opioid; Animals; CHO Cells; Constipation; Cricetulus; Diarrhea; Drug Partial Agonism; Gastrointestinal Agents; Gastrointestinal Transit; Imidazoles; Methylation; Mice; Molecular Docking Simulation; Morphine; Naltrexone; Narcotic Antagonists; Nociception; Phenylalanine; Quaternary Ammonium Compounds; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu

2018
Naltrexone and nalmefene attenuate cocaine place preference in male mice.
    Neuropharmacology, 2018, 09-15, Volume: 140

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics, Opioid; Animals; Cocaine; Conditioning, Psychological; Dose-Response Relationship, Drug; Locomotion; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists

2018
Evaluation of samidorphan, a μ-opioid antagonist, in a drug discrimination assay in rats.
    Drug development research, 2018, Volume: 79, Issue:5

    Topics: Animals; Discrimination, Psychological; Dose-Response Relationship, Drug; Humans; Male; Morphine; Naltrexone; Narcotic Antagonists; Rats, Sprague-Dawley; Receptors, Opioid, mu

2018
Pharmacological Characterization of Dezocine, a Potent Analgesic Acting as a κ Partial Agonist and μ Partial Agonist.
    Scientific reports, 2018, 09-20, Volume: 8, Issue:1

    Topics: Analgesics, Opioid; Animals; Bridged Bicyclo Compounds, Heterocyclic; CHO Cells; Cricetulus; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Female; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Nociception; Pain Measurement; Protein Binding; Receptors, Opioid, kappa; Receptors, Opioid, mu; Signal Transduction; Tetrahydronaphthalenes

2018
Short term exposure to oxycodone alters the survival, proliferation and differentiation of rat embryonic neural stem cell in vitro.
    Brain research bulletin, 2018, Volume: 143

    Topics: Analgesics, Opioid; Animals; Apoptosis; Cell Differentiation; Cell Proliferation; Cell Survival; Embryonic Stem Cells; Female; Morphine; Naltrexone; Neural Stem Cells; Oxycodone; Pregnancy; Rats; Rats, Sprague-Dawley

2018
Extended-release morphine sulfate and naltrexone hydrochloride (EMBEDA): naltrexone-associated withdrawal and abuse-related effects in patients with chronic pain and recreational opioid users.
    Current medical research and opinion, 2019, Volume: 35, Issue:3

    Topics: Adult; Chronic Pain; Delayed-Action Preparations; Drug Combinations; Female; Humans; Male; Middle Aged; Morphine; Naltrexone; Opioid-Related Disorders; Substance Withdrawal Syndrome

2019
Pharmacological classification of centrally acting drugs using EEG in freely moving rats: an old tool to identify new atypical dopamine uptake inhibitors.
    Neuropharmacology, 2019, 12-15, Volume: 161

    Topics: Animals; Central Nervous System Agents; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Discovery; Electroencephalography; Heroin; Ketamine; Male; Methylphenidate; Modafinil; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu

2019
Effectiveness comparisons of G-protein biased and unbiased mu opioid receptor ligands in warm water tail-withdrawal and drug discrimination in male and female rats.
    Neuropharmacology, 2019, 05-15, Volume: 150

    Topics: Analgesics, Opioid; Animals; Discrimination Learning; Female; Fentanyl; Male; Morphine; Naltrexone; Narcotic Antagonists; Nociception; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Spiro Compounds; Thiophenes

2019
Real-world misuse, abuse, and dependence of abuse-deterrent versus non-abuse-deterrent extended-release morphine in Medicaid non-cancer patients.
    Postgraduate medicine, 2019, Volume: 131, Issue:3

    Topics: Adolescent; Adult; Analgesics, Opioid; Cohort Studies; Delayed-Action Preparations; Female; Humans; Male; Medicaid; Middle Aged; Morphine; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Patient Acceptance of Health Care; Prescription Drug Misuse; Retrospective Studies; United States; Young Adult

2019
Suppression of Human Natural Killer Cells by Different Classes of Opioids.
    Anesthesia and analgesia, 2019, Volume: 128, Issue:5

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Anesthesia; Buprenorphine; Enkephalin, D-Penicillamine (2,5)-; Fentanyl; Fluoresceins; Humans; Immunosuppression Therapy; K562 Cells; Killer Cells, Natural; Loperamide; Methadone; Morphinans; Morphine; Naloxone; Naltrexone; Succinimides; Toll-Like Receptor 4; Tramadol

2019
Study on structural insight of the analysis of negative effects of opioids analgesics in naltrexone with TLR4 Mutations.
    Pakistan journal of pharmaceutical sciences, 2019, Volume: 32, Issue:1(Suppleme

    Topics: Analgesics, Opioid; Humans; Morphine; Mutation; Naltrexone; Narcotic Antagonists; Toll-Like Receptor 4

2019
μ-Opioid receptor in the CA1 involves in tramadol and morphine cross state-dependent memory.
    Neuroscience letters, 2019, 07-13, Volume: 705

    Topics: Amnesia; Animals; Avoidance Learning; CA1 Region, Hippocampal; Dose-Response Relationship, Drug; Drug Interactions; Male; Memory; Mental Recall; Microinjections; Morphine; Naltrexone; Rats; Receptors, Opioid, mu; Tramadol

2019
A preliminary study of the effect of naldemedine tosylate on opioid-induced nausea and vomiting.
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2020, Volume: 28, Issue:3

    Topics: Aged; Analgesics, Opioid; Antiemetics; Constipation; Female; Humans; Incidence; Male; Middle Aged; Morphine; Naltrexone; Narcotic Antagonists; Nausea; Oxycodone; Receptors, Opioid; Retrospective Studies; Vomiting

2020
Cross-talk between Human Spinal Cord μ-opioid Receptor 1Y Isoform and Gastrin-releasing Peptide Receptor Mediates Opioid-induced Scratching Behavior.
    Anesthesiology, 2019, Volume: 131, Issue:2

    Topics: Aged; Analgesics, Opioid; Animals; Behavior, Animal; Cadaver; Disease Models, Animal; Humans; Male; Mice; Mice, Inbred C57BL; Morphine; Naltrexone; Narcotic Antagonists; Pruritus; Receptors, Bombesin; Receptors, Opioid, mu; Spinal Cord

2019
Methylnaltrexone to Reduce the Inhibitory Effects of Opioids on Drug Absorption.
    JACC. Cardiovascular interventions, 2019, 08-26, Volume: 12, Issue:16

    Topics: Analgesics, Opioid; Coronary Artery Disease; Humans; Morphine; Naltrexone; Quaternary Ammonium Compounds; Ticagrelor; Treatment Outcome

2019
Effectiveness and selectivity of a heroin conjugate vaccine to attenuate heroin, 6-acetylmorphine, and morphine antinociception in rats: Comparison with naltrexone.
    Drug and alcohol dependence, 2019, 11-01, Volume: 204

    Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Administration Routes; Female; Fentanyl; Heroin; Male; Morphine; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Rats; Tetanus Toxoid; Vaccination

2019
Changes in fentanyl demand following naltrexone, morphine, and buprenorphine in male rats.
    Drug and alcohol dependence, 2020, 02-01, Volume: 207

    Topics: Animals; Buprenorphine; Dose-Response Relationship, Drug; Drug Interactions; Fentanyl; Male; Morphine; Naltrexone; Rats; Receptors, Opioid; Receptors, Opioid, mu; Reinforcement Schedule; Self Administration

2020
Morphine induces the differentiation of T helper cells to Th2 effector cells via the PKC-θ-GATA3 pathway.
    International immunopharmacology, 2020, Volume: 80

    Topics: Analgesics, Opioid; Animals; Cell Differentiation; GATA3 Transcription Factor; Interferon-gamma; Interleukin-4; Male; Mice, Inbred C57BL; Morphine; Naltrexone; Narcotic Antagonists; Protein Kinase C-theta; Pyrroles; Quinazolines; T-Lymphocytes, Helper-Inducer

2020
Sigma receptor-induced heavy drinking in rats: Modulation by the opioid receptor system.
    Pharmacology, biochemistry, and behavior, 2020, Volume: 192

    Topics: Animals; Binge Drinking; Central Nervous System Depressants; Dose-Response Relationship, Drug; Ethanol; Guanidines; Male; Morphine; Naltrexone; Narcotic Antagonists; Rats; Receptors, sigma; Self Administration

2020
Antagonism of peripheral opioid receptors by methylnaltrexone does not prevent morphine tolerance in rats.
    Journal of neuroscience research, 2022, Volume: 100, Issue:1

    Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Male; Morphine; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, mu

2022
Single-molecule analysis reveals agonist-specific dimer formation of µ-opioid receptors.
    Nature chemical biology, 2020, Volume: 16, Issue:9

    Topics: Animals; beta-Arrestins; CHO Cells; Cricetulus; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Fluorescence Resonance Energy Transfer; Morphine; Mutation; Naloxone; Naltrexone; Narcotic Antagonists; Phosphorylation; Protein Multimerization; Receptors, Opioid, mu; Single Molecule Imaging

2020
Behavioral effects of benzylideneoxymorphone (BOM), a low efficacy µ opioid receptor agonist and a δ opioid receptor antagonist.
    Psychopharmacology, 2020, Volume: 237, Issue:12

    Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Male; Morphine; Naltrexone; Narcotic Antagonists; Oxymorphone; Pain; Pain Measurement; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Reinforcement, Psychology; Self Administration

2020
The role of opioidergic system in modulating cost/benefit decision-making in alcohol-preferring AA rats and Wistar rats.
    Behavioural pharmacology, 2021, 04-01, Volume: 32, Issue:2&3

    Topics: Alcohol Drinking; Analgesics, Opioid; Animals; Behavior, Animal; Cost-Benefit Analysis; Decision Making; Gambling; Male; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Reward; Sucrose

2021
Methylnaltrexone crosses the blood-brain barrier and attenuates centrally-mediated behavioral effects of morphine and oxycodone in mice.
    Neuropharmacology, 2021, 03-01, Volume: 185

    Topics: Analgesics, Opioid; Animals; Blood-Brain Barrier; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred C57BL; Morphine; Naltrexone; Narcotic Antagonists; Oxycodone; Pain Measurement; Quaternary Ammonium Compounds

2021
Systematic Structure-Based Virtual Screening Approach to Antibody Selection and Design of a Humanized Antibody against Multiple Addictive Opioids without Affecting Treatment Agents Naloxone and Naltrexone.
    ACS chemical neuroscience, 2021, 01-06, Volume: 12, Issue:1

    Topics: Analgesics, Opioid; Heroin; Morphine; Naloxone; Naltrexone

2021
Characterization of a mouse neuropathic pain model caused by the highly active antiviral therapy (HAART) Stavudine.
    Pharmacological reports : PR, 2021, Volume: 73, Issue:5

    Topics: Animals; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Morphine; Naltrexone; Neuralgia; Stavudine

2021
Antinociceptive Efficacy of the µ-Opioid/Nociceptin Peptide-Based Hybrid KGNOP1 in Inflammatory Pain without Rewarding Effects in Mice: An Experimental Assessment and Molecular Docking.
    Molecules (Basel, Switzerland), 2021, 05-28, Volume: 26, Issue:11

    Topics: Acute Pain; Analgesics; Animals; Behavior, Animal; CHO Cells; Cricetinae; Cricetulus; Cycloheptanes; Humans; Hyperalgesia; In Vitro Techniques; Inflammation; Male; Mice; Models, Molecular; Molecular Docking Simulation; Morphine; Movement; Naloxone; Naltrexone; Nociceptin; Oligopeptides; Opioid Peptides; Pain Management; Piperidines; Receptors, Opioid, mu

2021
Morphine attenuates neuroinflammation and blood-brain barrier disruption following traumatic brain injury through the opioidergic system.
    Brain research bulletin, 2021, Volume: 176

    Topics: Analgesics, Opioid; Animals; Blood-Brain Barrier; Brain; Brain Injuries, Traumatic; Disease Models, Animal; Male; Morphine; Naltrexone; Neuroinflammatory Diseases; Neuroprotective Agents; Rats; Rats, Wistar

2021
Opioid Antagonist Nanodrugs Successfully Attenuate the Severity of Ischemic Stroke.
    Molecular pharmaceutics, 2022, 07-04, Volume: 19, Issue:7

    Topics: Analgesics, Opioid; Animals; Ischemic Stroke; Mice; Morphine; Naloxone; Naltrexone; Nanoparticles; Narcotic Antagonists; Opioid-Related Disorders; Oxycodone; Stroke; Tight Junction Proteins

2022
A Journey through Diastereomeric Space: The Design, Synthesis, In Vitro and In Vivo Pharmacological Activity, and Molecular Modeling of Novel Potent Diastereomeric MOR Agonists and Antagonists.
    Molecules (Basel, Switzerland), 2022, Sep-30, Volume: 27, Issue:19

    Topics: Animals; CHO Cells; Colforsin; Cricetinae; Ligands; Mice; Morphine; Naltrexone; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Respiratory Insufficiency

2022
Functional consequences of short-term exposure to opioids versus cannabinoids in nonhuman primates.
    Neuropharmacology, 2023, Feb-01, Volume: 223

    Topics: Analgesics, Opioid; Animals; Cannabinoid Receptor Agonists; Cannabinoids; Dose-Response Relationship, Drug; Dronabinol; Female; Heroin; Male; Morphine; Naltrexone; Rimonabant

2023
Promising biomedical subcutaneous delivery system in opioid disaccustom process: In vitro/in vivo evaluation of naloxone microparticles on antagonist effect of morphine.
    International journal of pharmaceutics, 2023, Mar-25, Volume: 635

    Topics: Analgesics, Opioid; Animals; Guinea Pigs; Humans; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Neuroblastoma

2023
Inhibitory Effects of a Novel μ-Opioid Receptor Nonpeptide Antagonist, UD-030, on Morphine-Induced Conditioned Place Preference.
    International journal of molecular sciences, 2023, Feb-08, Volume: 24, Issue:4

    Topics: Analgesics, Opioid; Animals; Humans; Mice; Mice, Inbred C57BL; Morphine; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Receptors, Opioid, delta; Receptors, Opioid, mu

2023
Fentanyl analog structure-activity relationships demonstrate determinants of diverging potencies for antinociception and respiratory depression.
    Pharmacology, biochemistry, and behavior, 2023, Volume: 226

    Topics: Analgesics, Opioid; Animals; Fentanyl; Hypoventilation; Male; Mice; Morphine; Naltrexone; Receptors, Opioid, mu

2023
A MOR Antagonist with High Potency and Antagonist Efficacy among Diastereomeric C9-Alkyl-Substituted
    Molecules (Basel, Switzerland), 2023, Jul-14, Volume: 28, Issue:14

    Topics: Analgesics, Opioid; Morphinans; Morphine; Naltrexone; Receptors, Opioid, mu; Structure-Activity Relationship

2023
Extinction and reinstatement of methamphetamine-induced conditioned place preference in zebrafish.
    Addiction biology, 2023, Volume: 28, Issue:12

    Topics: Animals; Clonidine; Extinction, Psychological; Methamphetamine; Morphine; Naltrexone; Recurrence; Zebrafish

2023