naltrexone has been researched along with morphinans in 238 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 38 (15.97) | 18.7374 |
| 1990's | 103 (43.28) | 18.2507 |
| 2000's | 33 (13.87) | 29.6817 |
| 2010's | 54 (22.69) | 24.3611 |
| 2020's | 10 (4.20) | 2.80 |
| Authors | Studies |
|---|---|
| Archer, S; Michne, WF | 1 |
| Colombel, MC; Jacob, J; Tremblay, E | 1 |
| Eades, CG; Gilbert, PE; Huppler, RE; Martin, WR; Thompson, JA | 1 |
| Berggren, A; Rubenson, A; Sillén, U | 1 |
| Bowen, WD; Farmer, SC; Mattia, A; Mosberg, HI; Porreca, F; Portoghese, PS; Sultana, M; Takemori, AE | 1 |
| Horvath, R; Hruby, VJ; Knapp, RJ; Malatynska, E; Otvos, F; Porreca, F; Toth, G; Yamamura, HI; Yamamura, MS | 1 |
| Akami, T; Arakawa, K; Matsumoto, S; Nagase, H; Oka, T; Okamoto, M | 1 |
| Akami, T; Arakawa, K; Matsumoto, S; Mitsuo, M; Nagase, H; Nakai, I; Nakajima, H; Oka, T; Okamoto, M | 1 |
| Nagase, H; Portoghese, PS; Sultana, M; Takemori, AE | 1 |
| Bourgoin, S; Cesselin, F; Collin, E; Ferhat, L; Hamon, M | 1 |
| Kane, K; McIntosh, M; Parratt, J | 2 |
| Broccardo, M; Improta, G | 1 |
| Kamei, J; Kasuya, Y; Kawashima, N | 1 |
| Giles, A; Landymore, KM; Wilkinson, M | 1 |
| Kamei, J; Kasuya, Y; Tanihara, H | 2 |
| Maier, SF; Watkins, LR; Wiertelak, EP | 2 |
| Holtzman, SG; Jones, DN | 1 |
| Hammond, DL; Rafferty, MF; Stapelfeld, A | 1 |
| Dickenson, AH; Kalso, EA; McQuay, HJ; Sullivan, AF | 1 |
| Cheng, PY; Cheng, Y; Decena, J; McCabe, S; Szeto, HH; Wu, DL | 1 |
| Dewey, WL; Smith, FL | 1 |
| De Vries, TJ; Hogenboom, F; Hruby, VJ; Mulder, AH; Portoghese, PS; Schoffelmeer, AN | 1 |
| Malmberg, AB; Yaksh, TL | 1 |
| Crook, TJ; Hill, RG; Kitchen, I | 1 |
| Freye, E; Latasch, L; Portoghese, PS | 1 |
| Klein, P; Nelson, WL; Portoghese, PS; Sultana, M; Takemori, AE | 1 |
| Larson, DL; Portoghese, PS; Sultana, M; Takemori, AE | 1 |
| Klein, P; Nelson, WL | 1 |
| Le, AD; Poulos, CX; Walker, MJ | 1 |
| Bertalmio, AJ; Woods, JH | 1 |
| Kameyama, T; Toyoshi, T; Ukai, M | 1 |
| Griffin, IJ; Jackson, HC; Nutt, DJ | 1 |
| Derrick, BE; Lieberman, DN; Martinez, JL; Rodriguez, SB | 1 |
| Adler, MW; Geller, EB; Handler, CM | 1 |
| Larson, AA; Mousseau, DD; Sun, X | 1 |
| Bilsky, EJ; Menkens, K; Porreca, F; Portoghese, PS; Reid, LD; Wild, KD | 1 |
| Kawabata, A; Nishimura, Y; Takagi, H | 1 |
| Fournié-Zaluski, MC; Noble, F; Roques, BP; Turcaud, S | 1 |
| Stamidis, H; Young, GA | 1 |
| Bourgoin, S; Cesselin, F; Collin, E; Hamon, M; Mantelet, S | 1 |
| Blalock, JE; Carr, DJ; DeCosta, BR; Radulescu, RT; Rice, KC | 2 |
| Misawa, M; Nagase, H; Narita, M; Suzuki, T | 2 |
| Carboni, E; Di Chiara, G; Garau, L; Longoni, R; Melchiorri, P; Mulas, A; Spina, L | 1 |
| Bowen, WD; Jiang, Q; Mosberg, HI; Porreca, F; Portoghese, PS; Sultana, M; Takemori, AE | 1 |
| Jackson, HC; Nutt, DJ | 2 |
| Portoghese, PS | 1 |
| Calenco-Choukroun, G; Daugé, V; Féger, J; Gacel, G; Roques, BP | 1 |
| Abdelhamid, EE; Portoghese, PS; Sultana, M; Takemori, AE | 1 |
| Kaneto, H; Kawasaki, K; Kobayashi, Y; Maeda, M; Shimokawa, K; Taguchi, T; Takahashi, M; Tokuyama, S; Watanabe, J; Yamamoto, Y | 1 |
| de Costa, BR; Drower, EJ; Hammond, DL; Rafferty, MF; Rice, KC; Stapelfeld, A | 1 |
| Angelucci, F; Negri, L; Noviello, V | 1 |
| Song, ZH; Takemori, AE | 1 |
| Bourgoin, S; Cesselin, F; Chantrel, D; Collin, E; Hamon, M; Mauborgne, A | 1 |
| Burks, TF; Davis, TP; Greene, DL; Hersh, LB; Hruby, VJ; Kramer, TH; Sharma, SD; Weber, SJ; Yamamura, HI | 1 |
| Ayres, EA; Burks, TF; Fang, S; Hruby, VJ; Kramer, TH; Parkhurst, DN | 1 |
| Giordano, J; Hughes, RA; Sufka, KJ | 1 |
| Portoghese, PS; Sofuoglu, M; Takemori, AE | 1 |
| Baamonde, A; Daugé, V; Gacel, G; Roques, BP | 1 |
| Lin, CE; MaloneyHuss, KE; Nagase, H; Portoghese, PS; Takemori, AE | 1 |
| Lawrence, AJ; Traynor, JR | 1 |
| Birch, PJ; Hayes, AG; Lawrence, AJ; Rogers, H; Traynor, JR | 1 |
| Calcagnetti, DJ; Holtzman, SG | 1 |
| Froimowitz, M | 1 |
| Fukagawa, Y; Misawa, M; Nagase, H; Suzuki, T | 2 |
| de Costa, BR; France, CP; Jacobson, AE; Rice, KC; Woods, JH | 1 |
| Portoghese, PS; Sultana, M; Takemori, AE | 3 |
| Dykstra, LA | 2 |
| Chalmers, J; Drolet, G; Morilak, D | 1 |
| Kitchen, I; Pinker, SR | 1 |
| Kaneto, H; Senda, T; Takahashi, M; Tokuyama, S | 1 |
| Ayres, EA; Burks, TF; Davis, P | 1 |
| Calcagnetti, DJ; Calcagnetti, RL; Fanselow, MS | 1 |
| Bergman, J; Warren, PH | 1 |
| Dougall, IG; Leff, P | 2 |
| Calcagnetti, DJ; Fanselow, MS; Helmstetter, FJ | 1 |
| Gurll, NJ; Holaday, JW; Lechner, RB; Reynolds, DG | 1 |
| Jackson, HC; Nutt, DJ; Ripley, TL | 1 |
| Comer, S; DeCosta, B; France, CP; Jacobson, AE; Medzihradsky, F; Rice, KC; Smith, CB; Winger, G; Woods, JH | 1 |
| Cooper, SJ; Kirkham, TC | 1 |
| Bhargava, HN; Gulati, A | 1 |
| Corbett, AD; Kosterlitz, HW | 1 |
| Corbett, AD; Kosterlitz, HW; Traynor, JR | 1 |
| Calcagnetti, DJ; Cramer, CP; Fanselow, MS; Helmstetter, FJ | 1 |
| Birch, PJ; Hayes, AG | 1 |
| Erking, W; Lücker, PW; Wetzelsberger, N | 1 |
| Kreeger, TJ; Plotka, ED; Seal, US | 1 |
| Mello, NK; Mendelson, JH | 1 |
| France, CP; Woods, JH | 1 |
| Baskin, DS; Grevel, JC; Hosobuchi, Y | 1 |
| Aliyu, SU; Badawy, AA | 1 |
| Jacobson, AE; Rice, KC; Sadée, W; Yu, VC | 1 |
| Freye, E; Hartung, E; Kaliebe, S | 1 |
| Freye, E; Hartung, E; Schenk, GK | 1 |
| France, CP; Jacobson, AE; Woods, JH | 2 |
| Fries, DS; Larson, DL; Portoghese, PS; Sayre, LM; Takemori, AE | 1 |
| Byrne, WL; Codd, EE | 1 |
| Dum, JE; Herz, A | 1 |
| Herman, BH; Holtzman, SG | 1 |
| Katz, RJ; Manik, CP | 1 |
| Cooper, SJ; Holtzman, SG | 1 |
| Herling, S; Solomon, RE; Woods, JH | 1 |
| Dixon, R; Hsiao, J | 1 |
| Jasinski, DR | 1 |
| Cosentino, M; De Ponti, F; Frigo, G; Giaroni, C; Lecchini, S; Leoni, O; Marino, F; Somaini, L | 1 |
| Randich, A; Robertson, JD; Willingham, T | 1 |
| Olmsted, SL; Portoghese, PS; Takemori, AE | 1 |
| Acquas, E; Di Chiara, G; Meloni, M | 1 |
| Cheng, PY; Decena, J; McCabe, S; Soong, Y; Szeto, HH; Wu, D | 1 |
| Lanthorn, TH; Watson, GB | 1 |
| Bowen, WD; Carlisi, VJ; Hruby, VJ; Mosberg, HI; Porreca, F; Portoghese, PS; Sultana, M; Takemori, AE; Wild, KD | 1 |
| Bilsky, EJ; Glaccum, MB; Hubbell, CL; Porreca, F; Portoghese, PS; Reid, LD | 1 |
| Akami, T; Akioka, K; Arakawa, K; Nagase, H; Nakai, I; Oka, T; Okamoto, M | 1 |
| Kameyama, T; Mori, E; Ukai, M | 1 |
| Contreras, PC; Dorn, CR; Drower, EJ; Markos, CS; Rafferty, MF; Unnerstall, JR | 1 |
| Miyamoto, Y; Portoghese, PS; Takemori, AE | 1 |
| Ho, IK; Hoskins, B; Jaw, SP | 1 |
| Bodnar, RJ; Koch, JE | 1 |
| Contreras, PC; Drower, E; Rafferty, MF; Tam, L | 1 |
| Aramaki, T; Inoki, R; Maeda, S; Ohnishi, T; Ooi, Y; Saito, K; Shinno, E | 1 |
| Spanagel, R | 1 |
| Chen, SF; Ghanta, VK; Hiramoto, RN; Hsueh, CM; Huang, HJ | 1 |
| Józefowski, S; Płytycz, B | 1 |
| Ananthan, S; Carter, RL; Clayton, SD; Davis, P; Johnson, CA; Porreca, F; Rice, KC; Rothman, RB; Xu, H | 1 |
| Gao, P; Larson, DL; Portoghese, PS | 1 |
| Hata, F; Nishio, H; Nishiwaki, H; Saitoh, N; Takeuchi, T | 1 |
| Hjorth, SA; Jones, RM; Portoghese, PS; Schwartz, TW | 1 |
| Amico, MC; Mattioli, F; Morrone, LA; Romanelli, L; Valeri, P | 1 |
| Ananthan, S; Bilsky, EJ; Carter, RL; Davis, P; Dersch, CM; Kezar, HS; Porreca, F; Rice, KC; Rothman, RB; Saini, SK; Wells, JL; Xu, H | 1 |
| Borsodi, A; Garzon, J; Hutcheson, DM; Maldonado, R; Rodriguez-Diaz, M; Roques, BP; Sánchez-Blazquez, P; Schmidhammer, H | 1 |
| Jones, RM; Portoghese, PS | 1 |
| Ferguson, DM; Jones, RM; Metzger, TG; Portoghese, PS; Stevens, WC; Subramanian, G | 1 |
| Ochoa , E | 1 |
| Matsumiya, T; Nagase, H; Narita, M; Suzuki, T; Takeda, H; Tsuji, M | 1 |
| Endoh, T; Izumimoto, N; Kamei, J; Mizoguchi, H; Nagase, H; Narita, M; Saitoh, A; Suzuki, T; Tajima, A; Tseng, LF | 1 |
| Billington, CJ; Grace, MK; Jewett, DC; Jones, RM; Levine, AS; Portoghese, PS | 1 |
| Brotchie, JM; Crossman, AR; Fox, SH; Henry, B | 1 |
| Dannals, RF; Mathews, WB; Musachio, JL; Ravert, HT; Scheffel, U | 1 |
| Ando, N; Endoh, T; Honda, T; Kamei, J; Kawamura, K; Nagase, H; Okano, K; Tanaka, T; Togashi, Y; Umeuchi, H; Utsumi, J; Yoshizawa, Y | 1 |
| Jones, RM; Linsenmayer, DC; Mello, NK; Negus, SS; Portoghese, PS | 1 |
| Ananthan, S; Davis, P; Dersch, CM; Kezar, HS; Khare, NK; Porreca, F; Rothman, RB; Saini, SK | 1 |
| Hung, KC; Leitermann, R; Mizoguchi, H; Nagase, H; Narita, M; Suzuki, T; Tseng, LF | 1 |
| Cao, Z; Liu, L; Van Winkle, DM | 1 |
| Honda, T; Nagase, H; Nakao, K; Okano, K; Tanaka, T; Togashi, Y; Umeuchi, H | 1 |
| Leitermann, RJ; Mizoguchi, H; Nagase, H; Narita, M; Suzuki, T; Tseng, LF | 1 |
| Aceto, MD; Husbands, SM; Lewis, JW; Miller, CN; Shefali, S; Srivastava, SK; Traynor, JR | 1 |
| Aoki, CA; Gershwin, ME; Itoh, M; Kato, T; Kawashima, Y; Kikuchi, K; Kurokawa, T; Miyakawa, H; Nakao, K; Okano, K; Umeuchi, H | 1 |
| Aimi, N; Horie, S; Ishikawa, H; Matsumoto, K; Murayama, T; Ponglux, D; Takayama, H; Watanabe, K | 1 |
| Li, W; Qiu, ZB; Tang, Y; Zheng, YL | 1 |
| Baamonde, A; García, V; Hidalgo, A; Juárez, L; Lastra, A; Menéndez, L | 1 |
| Herzog, H; Loacker, S; Sayyah, M; Schwarzer, C; Wittmann, W | 1 |
| Bidlack, JM; Knapp, BI; Neumeyer, JL; Peng, X | 1 |
| Divin, MF; Holden Ko, MC; Traynor, JR | 1 |
| Azar, MR; Berzetei-Gurske, I; Cashman, JR; Ghirmai, S; Polgar, WE | 1 |
| Bidlack, JM; Fulton, BS; Mathews, JL; Negus, SS; Neumeyer, JL | 1 |
| An, TH; Huang, LJ; Kim, WM; Kim, YO; Lee, HG; Yoon, MH | 1 |
| Fujii, H; Hanamura, S; Hasebe, K; Ishihara, M; Mochizuki, H; Nagase, H; Nakajima, M; Nemoto, T; Osa, Y | 1 |
| Gaburro, S; Herzog, H; Rosskothen, I; Schunk, E; Schwarzer, C; Singewald, N; Wittmann, W | 1 |
| Aschenbach, LC; Cassidy, MP; Chen, J; Dewey, WL; Gabra, BH; Li, G; Selley, DE; Stevens, DL; Westkaemper, RB; Zhang, Y | 1 |
| Fujii, H; Gouda, H; Hirono, S; Imai, M; Kanemasa, T; Kato, A; Nagase, H; Nakamura, T; Nemoto, T; Osa, Y | 1 |
| Hareyama, N; Ichinose, H; Ikeda, K; Kurokawa, T; Mochizuki, H; Nakajima, M; Nakao, K; Yoshikawa, S | 1 |
| Cowan, A; Dun, NJ; Inan, S | 3 |
| Filipek, S; Kolinski, M | 1 |
| Balleine, BW; Cely, IC; Maidment, NT; Wassum, KM | 1 |
| Clemens, MG; Day, SA; Lakner, AM; Moore, CC; Schrum, LW; Wu, ES; Yen, MH | 1 |
| Fujii, H; Nagase, H; Nemoto, T; Oka, J; Saitoh, A; Sugiyama, A; Wada, K; Yamada, M | 1 |
| Fujii, H; Nagase, H | 2 |
| Fujii, H; Hasebe, K; Mochizuki, H; Nagase, H; Nakajima, M; Nemoto, T; Watanabe, A | 1 |
| Gerk, PM; Mitra, P; Venitz, J; Yuan, Y; Zhang, Y | 1 |
| Assreuy, AM; Benevides, RG; Cavada, BS; Celedônio, NR; Coelho-de-Souza, AN; de Freitas Pires, A; Leal-Cardoso, JH; Lopes, ÉA; Nagano, CS; Rodrigues, NV; Santos, CF; Soares, CE; Sousa, PL | 1 |
| Acevedo, MB; Nizhnikov, ME; Pautassi, RM; Spear, NE | 1 |
| Carroll, FI; Cherezov, V; Han, GW; Huang, XP; Katritch, V; Liu, W; Mascarella, SW; Mileni, M; Mosier, PD; Roth, BL; Stevens, RC; Thompson, AA; Vardy, E; Wacker, D; Westkaemper, RB; Wu, H | 1 |
| Devi, LA; Filizola, M | 1 |
| Béguin, C; Berry, LM; Carlezon, WA; Carroll, FI; Cohen, BM; Munro, TA; Van't Veer, A; Zhao, Z | 1 |
| Dong, S; Li, M; Ma, G; Zhou, L | 1 |
| Cao, S; Dong, S; Li, M; Ma, G; Zhou, L | 1 |
| Dobek, E; Górski, K; Misztal, T; Romanowicz, K | 1 |
| Béguin, C; Carlezon, WA; Carroll, FI; Cohen, BM; Colabufo, NA; Huang, XP; Inglese, C; Munro, TA; Perrone, MG; Roth, BL; Van't Veer, A | 1 |
| Nagase, H; Oka, J; Saitoh, A; Sugiyama, A; Yamada, M | 1 |
| Kremer, AE; Mettang, T | 1 |
| Bailey, SJ; Casal-Dominguez, JJ; Clark, MJ; Furkert, D; Husbands, SM; Ostovar, M; Teintang, L; Traynor, JR | 1 |
| Ginsburg, BC; Lamb, RJ | 1 |
| Azar, MR; Cashman, JR | 1 |
| Thompson, CA | 1 |
| DiPetrillo, L; Ehrich, E; Silverman, B; Turncliff, R | 1 |
| Cowan, A; Inan, S; Kehner, GB | 1 |
| Grace, PM; Jacobson, AE; Rice, KC; Selfridge, BR; Wang, X; Watkins, LR; Yin, H; Zhang, Y | 1 |
| Backstedt, D; Jones, R; Prommer, E | 1 |
| Aubé, J; Bohn, LM; Frankowski, KJ; Morgenweck, J; Prisinzano, TE | 1 |
| Eans, SO; Ganno, ML; Hunkele, A; Le Rouzic, V; Majumdar, S; Marrone, GF; McLaughlin, JP; Pasternak, GW; Subrath, JJ; Váradi, A | 1 |
| de Groat, WC; Ferroni, MC; Kadow, BT; Kang, A; Lyon, TD; Roppolo, JR; Shen, B; Slater, RC; Tai, C; Wang, J; Xiao, Z; Zhang, Z | 1 |
| Higashi, Y; Nakamura, K; Saito, M; Shimizu, S; Shimizu, T; Taniuchi, K; Ueba, T; Yawata, T | 1 |
| Badke, A; Rosielle, DA | 1 |
| Weber, HC | 1 |
| Cheng, J; Li, W; Liu, G; Sun, X; Tang, Y; Tu, Y | 1 |
| Fujii, H; Hirayama, S; Ishikawa, K; Itoh, K; Mochizuki, Y; Nagai, K; Nemoto, T | 1 |
| Hang, A; Liu, JG; Long, Y; Shu, XH; Wang, Q; Wang, YJ; Zan, GY | 1 |
| Browne, CA; Erickson, RL; Lucki, I; Robinson, SA | 1 |
| Wirz, S | 1 |
| Andersson, H; Floettmann, E; Johnson, N; Mitchard, T | 1 |
| Abraham, AD; Andrews, MM; Baird, MA; Chavkin, C; Fontaine, HM; Kieffer, BL; Land, BB; Song, AJ | 1 |
| Chan, YH; Wang, YT | 1 |
| Murphy, JA; Sheridan, EA | 1 |
| Garcia, JM; Shamliyan, TA | 1 |
| Nagase, H; Oka, JI; Saitoh, A; Sugiyama, A; Yamada, M | 1 |
| Corsetti, M; Pannemans, J | 1 |
| Kayashima, S; Nagase, H; Oka, JI; Saitoh, A; Soda, A; Yamada, M; Yoshizawa, K | 1 |
| Jastrzebska, K; Przewlocki, R; Rodriguez Parkitna, J; Sikora, M; Skupio, U | 1 |
| Katsuyama, S; Komatsu, T; Kubota, A; Morinaga, O; Ogawa, K; Okamura, T; Sakurada, C; Sakurada, T; Tabata, K; Takano, F; Tsuzuki, M | 1 |
| Heller, NM; Maher, DP; Walia, D | 1 |
| Kreek, MJ; Zhou, Y | 2 |
| Nagase, H; Oka, JI; Saitoh, A; Yamada, D; Yanagisawa, S; Yanagita, S; Yoshizawa, K | 1 |
| Davis, AM; Micic, D; Rao, VL | 1 |
| Freeman, KB; Huskinson, SL; Naylor, JE; Prisinzano, TE; Townsend, EA; Zamarripa, CA | 1 |
| Hokari, R; Ishiyama, A; Iwatsuki, M; Koyama, Y; Kutsumura, N; Miyata, Y; Nagase, H; Nagumo, Y; Ōmura, S; Otoguro, K; Saitoh, T; Yamamoto, N | 1 |
| Brocklebank, J; Fingas, S; Miller, EJ | 1 |
| D'Ângelo, MQ; Ferreira, AJ; Maltos, KLM; Pacheco, CMDF; Queiroz-Junior, CM; Soares, RV | 1 |
| Baamonde, A; González-Rodríguez, S; Lastra, A; Machelska, H; Menéndez, L; Seitz, V; Stein, C | 1 |
| Townsend, EA | 1 |
| Iio, K; Nagase, H; Nishida, M; Saitoh, A; Sakamoto, K; Yamada, D; Yamanaka, N | 1 |
| Cao, D; Gillespie, JC; Liu-Chen, LY; Mendez, RE; Selley, DE; Wang, H; Zhang, Y | 1 |
| Ishizuka, Y; Kanbayashi, Y; Sawa, S; Shimizu, M; Uchida, M; Yabe, K | 1 |
| Chambers, DR; Jacobson, AE; Luo, D; Prisinzano, TE; Rice, KC; Sulima, A | 1 |
13 review(s) available for naltrexone and morphinans
| Article | Year |
|---|---|
Recent progress in research on narcotic antagonists.
Topics: Animals; Benzomorphans; Chemical Phenomena; Chemistry; Cyclazocine; Humans; In Vitro Techniques; Models, Biological; Morphinans; Morphine Derivatives; Nalbuphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pentazocine; Receptors, Opioid; Structure-Activity Relationship; Substance-Related Disorders; Thebaine | 1976 |
Behavioral pharmacology of buprenorphine.
Topics: Adult; Animals; Buprenorphine; Conditioning, Operant; Eating; Heroin Dependence; Humans; Macaca; Male; Methadone; Morphinans; Naltrexone; Opioid-Related Disorders; Reinforcement, Psychology; Self Administration | 1985 |
[Naltrexone in the treatment of alcohol addiction].
Topics: Alcoholism; Humans; Morphinans; Naltrexone | 2000 |
Synthesis of novel basic skeletons derived from naltrexone.
Topics: Animals; Humans; Morphinans; Naltrexone; Structure-Activity Relationship | 2011 |
Opioids in preclinical and clinical trials.
Topics: Amino Acid Sequence; Animals; Antitussive Agents; Clinical Trials as Topic; Drug Discovery; Humans; Molecular Sequence Data; Morphinans; Naltrexone; Receptors, Opioid, delta; Receptors, Opioid, kappa; Spiro Compounds; Structure-Activity Relationship | 2011 |
Uremic pruritus.
Topics: Acupuncture Therapy; Amines; Anti-Inflammatory Agents; Calcium Channel Blockers; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; gamma-Linolenic Acid; Humans; Morphinans; Naltrexone; Narcotic Antagonists; Pentoxifylline; Phototherapy; Pregabalin; Pruritus; Receptors, Opioid, kappa; Renal Insufficiency, Chronic; Spiro Compounds; Tacrolimus; Thalidomide; Uremia | 2015 |
Targeting Itch with Ligands Selective for κ Opioid Receptors.
Topics: Animals; Dynorphins; Guanidines; Humans; Ligands; Mice; Morphinans; Naltrexone; p-Methoxy-N-methylphenethylamine; Peptide Fragments; Pruritus; Receptors, Opioid, kappa; Spiro Compounds | 2015 |
Naloxegol: A Novel Therapy in the Management of Opioid-Induced Constipation.
Topics: Analgesics, Opioid; Constipation; Drug Interactions; Humans; Morphinans; Naltrexone; Narcotic Antagonists; Pain; Polyethylene Glycols; Quality of Life; Quaternary Ammonium Compounds; Randomized Controlled Trials as Topic | 2016 |
Opioid-induced constipation in chronic noncancer pain.
Topics: Analgesics, Opioid; Chloride Channel Agonists; Chronic Pain; Constipation; Humans; Lubiprostone; Morphinans; Naltrexone; Narcotic Antagonists; Polyethylene Glycols; Quaternary Ammonium Compounds; Receptors, Opioid, mu | 2016 |
[Management of adverse effects of opioid therapy].
Topics: Administration, Cutaneous; Administration, Oral; Analgesics, Opioid; Chronic Pain; Constipation; Drug-Related Side Effects and Adverse Reactions; Germany; Humans; Morphinans; Naltrexone; Narcotic Antagonists; Polyethylene Glycols; Quaternary Ammonium Compounds; Treatment Outcome | 2017 |
Evidence Based Review of Pharmacotherapy for Opioid-Induced Constipation in Noncancer Pain.
Topics: Analgesics, Opioid; Chronic Pain; Constipation; Evidence-Based Practice; Humans; Laxatives; Lubiprostone; Morphinans; Naltrexone; Narcotic Antagonists; Piperidines; Polyethylene Glycols; Quaternary Ammonium Compounds; Randomized Controlled Trials as Topic | 2018 |
Management of Opioid-Induced Constipation in Patients with Malignancy.
Topics: Analgesics, Opioid; Cancer Pain; Constipation; Enema; Gastrointestinal Agents; Gastrostomy; Humans; Laxatives; Morphinans; Naltrexone; Piperidines; Polyethylene Glycols; Practice Guidelines as Topic; Quaternary Ammonium Compounds | 2018 |
Opioid receptors in the GI tract: targets for treatment of both diarrhea and constipation in functional bowel disorders?
Topics: Analgesics, Opioid; Animals; Antidiarrheals; Constipation; Defecation; Diarrhea; Gastrointestinal Motility; Gastrointestinal Tract; Humans; Imidazoles; Inflammatory Bowel Diseases; Laxatives; Morphinans; Naltrexone; Narcotic Antagonists; Phenylalanine; Polyethylene Glycols; Quaternary Ammonium Compounds; Receptors, Opioid, mu; Signal Transduction | 2018 |
1 trial(s) available for naltrexone and morphinans
| Article | Year |
|---|---|
Single- and multiple-dose pharmacokinetics of samidorphan, a novel opioid antagonist, in healthy volunteers.
Topics: Administration, Oral; Adult; Area Under Curve; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Dyssomnias; Female; Half-Life; Healthy Volunteers; Humans; Male; Middle Aged; Morphinans; Naltrexone; Narcotic Antagonists | 2015 |
224 other study(ies) available for naltrexone and morphinans
| Article | Year |
|---|---|
[Precipitation and prevention of abstinence in acutely morphinized rats and mice: comparisons between naloxone, naltrexone, and diprenorphine (author's transl)].
Topics: Animals; Diprenorphine; Humans; Male; Mice; Morphinans; Morphine; Morphine Dependence; Naloxone; Naltrexone; Rats; Substance Withdrawal Syndrome; Time Factors | 1976 |
The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog.
Topics: Animals; Apomorphine; Cyclazocine; Cyclopropanes; Dextropropoxyphene; Dogs; Ethylketocyclazocine; Humans; Morphinans; Morphine; Morphine Dependence; Nalorphine; Naltrexone; Phenazocine; Spinal Cord | 1976 |
Involvement of opioid mechanisms in peripheral motor control of detrusor muscle.
Topics: Animals; Electric Stimulation; Enkephalins; Ganglionic Blockers; Hexamethonium; Hexamethonium Compounds; Humans; Indoles; Male; Morphinans; Morphine; Muscle Contraction; Muscles; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Substance P; Sympatholytics | 1992 |
Spinal opioid delta antinociception in the mouse: mediation by a 5'-NTII-sensitive delta receptor subtype.
Topics: Affinity Labels; Analgesics; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Isothiocyanates; Male; Mice; Mice, Inbred ICR; Morphinans; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain Measurement; Receptors, Opioid, delta; Spinal Cord; Thiocyanates | 1992 |
Characterization of [3H]naltrindole binding to delta opioid receptors in rat brain.
Topics: Animals; Binding, Competitive; Brain; Indoles; Male; Membranes; Morphinans; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta | 1992 |
The immunosuppressive effect of delta-opioid receptor antagonist on rat renal allograft survival.
Topics: Animals; Graft Survival; Immunosuppressive Agents; Indoles; Kidney Transplantation; Male; Morphinans; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Transplantation, Homologous | 1992 |
Immunosuppressive effect of delta-opioid receptor antagonist on xenogeneic mixed lymphocyte reaction.
Topics: Analgesics; beta-Endorphin; Cell Survival; Cells, Cultured; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Humans; Immunosuppressive Agents; Indoles; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Lymphocytes; Morphinans; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta | 1992 |
Agonist and antagonist activities of ligands derived from naltrexone and oxymorphone.
Topics: Animals; Indoles; Ligands; Male; Mice; Morphinans; Morpholines; Naltrexone; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa | 1992 |
Kappa-opioid receptor stimulation abolishes mu- but not delta-mediated inhibitory control of spinal Met-enkephalin release.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Indoles; Injections, Spinal; Male; Morphinans; Naloxone; Naltrexone; Neurons; Oligopeptides; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1992 |
Effects of selective opioid receptor agonists and antagonists during myocardial ischaemia.
Topics: Animals; Arrhythmias, Cardiac; Coronary Disease; Coronary Vessels; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Hemodynamics; Male; Morphinans; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1992 |
The electrophysiological effects of opioid receptor-selective antagonists on sheep Purkinje fibres.
Topics: Acidosis; Action Potentials; Animals; Coronary Disease; Hyperkalemia; Hypoxia; Morphinans; Naltrexone; Narcotic Antagonists; Purkinje Fibers; Sheep | 1992 |
Hypothermic effect of D-Ala-deltorphin II, a selective delta opioid receptor agonist.
Topics: Animals; Body Temperature; Indoles; Injections, Intraventricular; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta | 1992 |
Naloxone-induced analgesia in diabetic mice.
Topics: Analgesia; Animals; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Drug Interactions; Indoles; Injections, Subcutaneous; Male; Mice; Mice, Inbred ICR; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid | 1992 |
Ex vivo determination of opiate antagonist binding at mu-opioid ([3H]-DAGO) receptors in hypothalamic micropunches from maturing female rats: comparison between SDZ 210-096 and nalmefene.
Topics: Age Factors; Animals; Animals, Newborn; Binding, Competitive; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Hypothalamus; Morphinans; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Sexual Maturation; Vagina | 1992 |
Modulation of kappa-mediated antitussive activity in rats by a delta-agonist.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Antitussive Agents; Cough; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Indoles; Male; Morphinans; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Reflex | 1992 |
Delta opiate receptors mediate tail-shock induced antinociception at supraspinal levels.
Topics: Analysis of Variance; Animals; Cerebral Ventricles; Dose-Response Relationship, Drug; Electroshock; Indoles; Injections, Intraventricular; Injections, Spinal; Male; Morphinans; Naltrexone; Narcotic Antagonists; Pain; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Spinal Cord | 1992 |
Interaction between opioid antagonists and amphetamine: evidence for mediation by central delta opioid receptors.
Topics: Amphetamine; Analgesia; Animals; Brain; Indoles; Male; Morphinans; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta | 1992 |
Antinociception after intracerebroventricular administration of naltrindole in the mouse.
Topics: Animals; Dose-Response Relationship, Drug; Indoles; Injections, Intraventricular; Male; Mice; Morphinans; Naltrexone; Narcotic Antagonists; Nociceptors; Receptors, Opioid; Receptors, Opioid, delta | 1992 |
Spinal antinociception by Tyr-D-Ser(otbu)-Gly-Phe-Leu-Thr, a selective delta-opioid receptor agonist.
Topics: Amino Acid Sequence; Analgesics; Animals; Dose-Response Relationship, Drug; Indoles; Injections, Spinal; Male; Molecular Sequence Data; Morphinans; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta | 1992 |
Central opioid modulation of breathing dynamics in the fetal lamb: effects of [D-Pen2,D-Pen5]-enkephalin and partial antagonism by naltrindole.
Topics: Analgesics; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fetus; Indoles; Morphinans; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, mu; Respiration; Sheep | 1992 |
Evidence that endogenous opioids mediate the antinociceptive effects of intrathecally administered calcium in mice.
Topics: Analgesia; Animals; Calcium; Drug Interactions; Endorphins; Indoles; Injections, Spinal; Male; Mice; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid | 1992 |
Opioid receptor antagonists discriminate between presynaptic mu and delta receptors and the adenylate cyclase-coupled opioid receptor complex in the brain.
Topics: Acetylcholine; Adenylyl Cyclases; Animals; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Indoles; Male; Morphinans; Naltrexone; Narcotic Antagonists; Norepinephrine; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu | 1992 |
Isobolographic and dose-response analyses of the interaction between intrathecal mu and delta agonists: effects of naltrindole and its benzofuran analog (NTB).
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Indoles; Injections, Spinal; Male; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu | 1992 |
Effects of the delta-opioid receptor antagonist naltrindole on antinociceptive responses to selective delta-agonists in post-weanling rats.
Topics: Analgesics; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Indoles; Male; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain Measurement; Rats; Rats, Wistar; Receptors, Opioid, delta | 1992 |
The delta receptor is involved in sufentanil-induced respiratory depression--opioid subreceptors mediate different effects.
Topics: Animals; Carbon Dioxide; Dogs; Dose-Response Relationship, Drug; Evoked Potentials, Somatosensory; Indoles; Morphinans; Naltrexone; Narcotic Antagonists; Neurons, Afferent; Nociceptors; Oxygen; Receptors, Opioid; Receptors, Opioid, delta; Respiration; Sufentanil | 1992 |
Delta opioid antagonist activity and binding studies of regioisomeric isothiocyanate derivatives of naltrindole: evidence for delta receptor subtypes.
Topics: Animals; Binding, Competitive; Brain; Guinea Pigs; In Vitro Techniques; Isomerism; Isothiocyanates; Male; Mice; Morphinans; Muscle Contraction; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Structure-Activity Relationship; Thiocyanates | 1992 |
Opioid agonist and antagonist activities of morphindoles related to naltrindole.
Topics: Analgesia; Animals; Guinea Pigs; Indoles; Male; Mice; Morphinans; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Structure-Activity Relationship | 1992 |
O3-(2-carbomethoxyallyl) ethers of opioid ligands derived from oxymorphone, naltrexone, etorphine, diprenorphine, norbinaltorphimine, and naltrindole. Unexpected O3-dealkylation in the opioid radioligand displacement assay.
Topics: Alkylation; Animals; Brain; Diprenorphine; Drug Stability; Ethers; Etorphine; Guinea Pigs; Indoles; Methacrylates; Molecular Structure; Morphinans; Naltrexone; Narcotic Antagonists; Narcotics; Oxymorphone; Phenols; Radioligand Assay; Receptors, Opioid; Tritium | 1992 |
Effects of naltrindole and nor-binaltorphimine treatment on antinociception induced by sub-acute selective mu opioid receptor blockade.
Topics: Animals; Indoles; Male; Morphinans; Naltrexone; Pain; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sensitivity and Specificity | 1992 |
Discriminative stimulus effects of cyclorphan: selective antagonism with naltrexone.
Topics: Animals; Columbidae; Dextrorphan; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Generalization, Psychological; Levorphanol; Morphinans; Morphine; Naltrexone; Receptors, Opioid; Receptors, Opioid, mu; Stereoisomerism | 1992 |
Kappa opiate receptors mediate tail-shock induced antinociception at spinal levels.
Topics: Analysis of Variance; Animals; Dose-Response Relationship, Drug; Electroshock; Indoles; Injections, Spinal; Male; Morphinans; Naltrexone; Narcotic Antagonists; Pain; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Somatostatin; Spinal Cord | 1992 |
Combination of a delta opioid receptor agonist but not a mu opioid receptor agonist with the D1-selective dopamine receptor agonist SKF 38393 markedly potentiates different behaviors in mice.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Analysis of Variance; Animals; Behavior, Animal; Benzazepines; Dopamine Agents; Dopamine Antagonists; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Grooming; Indoles; Injections, Intraventricular; Male; Mice; Morphinans; Motor Activity; Naltrexone; Sulpiride | 1992 |
Endogenous opioids may be involved in idazoxan-induced food intake.
Topics: Adrenergic alpha-Antagonists; Animals; Dioxanes; Dose-Response Relationship, Drug; Eating; Endorphins; Idazoxan; Indoles; Male; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains | 1992 |
Mu opioid receptors are associated with the induction of hippocampal mossy fiber long-term potentiation.
Topics: Animals; Evoked Potentials; Hippocampus; Indoles; Male; Morphinans; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Somatostatin; Synapses; Time Factors | 1992 |
Effect of mu-, kappa-, and delta-selective opioid agonists on thermoregulation in the rat.
Topics: Amino Acid Sequence; Animals; Body Temperature; Body Temperature Regulation; Brain; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Indoles; Injections, Intraventricular; Male; Molecular Sequence Data; Morphinans; Naltrexone; Narcotic Antagonists; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1992 |
Identification of a novel receptor mediating substance P-induced behavior in the mouse.
Topics: Analysis of Variance; Animals; Behavior, Animal; Binding Sites; Indoles; Injections, Spinal; Male; Mice; Morphinans; Naloxone; Naltrexone; Peptide Fragments; Substance P | 1992 |
Cocaine place preference is blocked by the delta-opioid receptor antagonist, naltrindole.
Topics: Animals; Cocaine; Conditioning, Operant; Indoles; Male; Morphinans; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Lew | 1992 |
L-leucyl-L-arginine, naltrindole and D-arginine block antinociception elicited by L-arginine in mice with carrageenin-induced hyperalgesia.
Topics: Analgesics; Animals; Arginine; Brain; Carrageenan; Dipeptides; Endorphins; Hyperalgesia; Indoles; Injections, Subcutaneous; Male; Mice; Morphinans; Naltrexone; Narcotic Antagonists; Pain Measurement; Stereoisomerism | 1992 |
Repeated systemic administration of the mixed inhibitor of enkephalin-degrading enzymes, RB101, does not induce either antinociceptive tolerance or cross-tolerance with morphine.
Topics: Analgesics; Animals; Disulfides; Dose-Response Relationship, Drug; Drug Tolerance; Indoles; Male; Mice; Morphinans; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Phenylalanine; Prodrugs; Reaction Time | 1992 |
Naltrindole retards tolerance development to morphine-induced effects on EEG and EEG power spectra.
Topics: Animals; Brain; Drug Tolerance; Electroencephalography; Female; Indoles; Injections, Intraventricular; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains | 1992 |
Feedback inhibition of met-enkephalin release from the rat spinal cord in vivo.
Topics: Animals; Calcitonin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Feedback; Indoles; Injections, Spinal; Leucine; Male; Morphinans; Naloxone; Naltrexone; Oligopeptides; Radioimmunoassay; Rats; Rats, Inbred Strains; Spinal Cord; Thiorphan | 1992 |
Opioid modulation of immunoglobulin production by lymphocytes isolated from Peyer's patches and spleen.
Topics: Animals; Antibody Formation; Cells, Cultured; Concanavalin A; In Vitro Techniques; Indoles; Lipopolysaccharides; Lymphocytes; Morphinans; Morpholines; Naltrexone; Peyer's Patches; Spleen | 1992 |
Pentazocine-induced biphasic analgesia in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics; Animals; Drug Administration Schedule; Drug Interactions; Drug Tolerance; Indoles; Injections, Intraventricular; Male; Mice; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Pentazocine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Time Factors | 1991 |
(D-Ala2)deltorphin II: D1-dependent stereotypies and stimulation of dopamine release in the nucleus accumbens.
Topics: Animals; Brain; Caudate Nucleus; Cerebral Ventricles; Dopamine; Endorphins; Functional Laterality; Indoles; Infusions, Parenteral; Injections, Intraventricular; Male; Morphinans; Motor Activity; Naloxone; Naltrexone; Nucleus Accumbens; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Stereotyped Behavior | 1991 |
Differential antagonism of opioid delta antinociception by [D-Ala2,Leu5,Cys6]enkephalin and naltrindole 5'-isothiocyanate: evidence for delta receptor subtypes.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Injections, Intraventricular; Isothiocyanates; Male; Mice; Mice, Inbred ICR; Morphinans; Naltrexone; Narcotic Antagonists; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta; Thiocyanates | 1991 |
Differential effects of selective mu-, kappa- and delta-opioid antagonists on electroshock seizure threshold in mice.
Topics: Animals; Anticonvulsants; Bicuculline; Dose-Response Relationship, Drug; Electroshock; gamma-Aminobutyric Acid; Indoles; Male; Mice; Mice, Inbred Strains; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Phenytoin; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1991 |
An approach to the design of receptor-type-selective non-peptide antagonists of peptidergic receptors: delta opioid antagonists.
Topics: Amino Acid Sequence; Drug Design; Enkephalins; Indoles; Molecular Sequence Data; Morphinans; Naltrexone; Protein Conformation; Receptors, Opioid; Receptors, Opioid, delta; Structure-Activity Relationship | 1991 |
Opioid delta agonists and endogenous enkephalins induce different emotional reactivity than mu agonists after injection in the rat ventral tegmental area.
Topics: Animals; Anxiety; Emotions; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Exploratory Behavior; Indoles; Injections; Male; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Tegmentum Mesencephali | 1991 |
Selective blockage of delta opioid receptors prevents the development of morphine tolerance and dependence in mice.
Topics: Animals; Drug Implants; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Indoles; Isothiocyanates; Male; Mice; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Nociceptors; Receptors, Opioid; Receptors, Opioid, delta; Substance-Related Disorders; Thiocyanates | 1991 |
The opioid activity and receptor selectivity of fluorinated Leu5 enkephalin analogues in vitro and in vivo.
Topics: Analgesics; Animals; Enkephalin, Leucine; Guinea Pigs; Ileum; In Vitro Techniques; Indoles; Male; Mice; Mice, Inbred Strains; Morphinans; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid | 1991 |
Selective antagonism by naltrindole of the antinociceptive effects of the delta opioid agonist cyclic[D-penicillamine2-D-penicillamine5]enkephalin in the rat.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Indoles; Injections, Spinal; Injections, Subcutaneous; Male; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Nociceptors; Pain Measurement; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord | 1991 |
Modulation of mu-mediated antitussive activity in rats by a delta agonist.
Topics: Aerosols; Animals; Antitussive Agents; Capsaicin; Cisterna Magna; Cough; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Indoles; Injections; Male; Morphinans; Morphine; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1991 |
Behavioural effects of deltorphins in rats.
Topics: Analgesics; Animals; Behavior, Animal; Indoles; Injections, Intraventricular; Male; Morphinans; Motor Activity; Naloxone; Naltrexone; Oligopeptides; Pain Measurement; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Social Behavior; Stereotyped Behavior | 1991 |
Involvement of spinal kappa opioid receptors in the antagonistic effect of dynorphins on morphine antinociception.
Topics: Animals; Dynorphins; Indoles; Male; Mice; Morphinans; Morphine; Naltrexone; Pain; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Spine; Stereoisomerism | 1991 |
Investigation of the different types of opioid receptor involved in electroconvulsive shock-induced antinociception and catalepsy in the rat.
Topics: Analgesia; Animals; Catalepsy; Electroshock; Indoles; Injections, Intraperitoneal; Male; Morphinans; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid | 1991 |
In vivo tonic inhibition of spinal substance P (-like material) release by endogenous opioid(s) acting at delta receptors.
Topics: Amino Acid Sequence; Animals; Depression, Chemical; Indoles; Injections, Spinal; Male; Molecular Sequence Data; Morphinans; Naloxone; Naltrexone; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Secretory Rate; Spinal Cord; Substance P | 1991 |
Distribution and analgesia of [3H][D-Pen2, D-Pen5]enkephalin and two halogenated analogs after intravenous administration.
Topics: Analgesics; Animals; Binding, Competitive; Drug Stability; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Indoles; Injections, Intravenous; Male; Mice; Mice, Inbred Strains; Morphinans; Naloxone; Naltrexone; Neprilysin; Tissue Distribution; Tritium | 1991 |
Antinociceptive and gastrointestinal transit effects of cholecystokinin (CCK-8) and related analogs of CCK-8 in the mouse.
Topics: Amino Acid Sequence; Analgesics; Animals; Benzodiazepinones; Cholecystokinin; Devazepide; Gastric Emptying; Gastrointestinal Transit; Indoles; Male; Mice; Mice, Inbred ICR; Molecular Sequence Data; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Peptide Fragments; Peptides; Phenylurea Compounds; Reaction Time; Receptors, Cholecystokinin; Sincalide | 1991 |
Effects of selective opiate antagonists on morphine-induced hyperalgesia in domestic fowl.
Topics: Analgesia; Animals; Chickens; Dose-Response Relationship, Drug; Hot Temperature; Indoles; Injections, Intraventricular; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Respiration | 1991 |
Differential antagonism of delta opioid agonists by naltrindole and its benzofuran analog (NTB) in mice: evidence for delta opioid receptor subtypes.
Topics: Analgesia; Animals; Indoles; Male; Mice; Morphinans; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta | 1991 |
Systemic administration of (Tyr-D-Ser(O-tert-butyl)-Gly-Phe-Leu-Thr(O-tert-butyl), a highly selective delta opioid agonist, induces mu receptor-mediated analgesia in mice.
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Indoles; Injections, Intravenous; Male; Mice; Morphinans; Naltrexone; Narcotic Antagonists; Oligopeptides; Receptors, Opioid; Receptors, Opioid, mu | 1991 |
Role of spacer and address components in peptidomimetic delta opioid receptor antagonists related to naltrindole.
Topics: Animals; Chemical Phenomena; Chemistry; Guinea Pigs; Indoles; Male; Mice; Morphinans; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Structure-Activity Relationship | 1991 |
Characterisation of opioid binding sites using selective antagonists.
Topics: Animals; Binding, Competitive; Brain; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; In Vitro Techniques; Indoles; Morphinans; Naltrexone; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Somatostatin | 1990 |
The selectivity of the opioid antagonist, naltrindole, for delta-opioid receptors.
Topics: Animals; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guanylyl Imidodiphosphate; Guinea Pigs; In Vitro Techniques; Indoles; Male; Mice; Mice, Inbred Strains; Morphinans; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sodium; Vas Deferens | 1990 |
Delta opioid antagonist, naltrindole, selectively blocks analgesia induced by DPDPE but not DAGO or morphine.
Topics: Analgesia; Analgesics; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Indoles; Injections, Intraventricular; Male; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Reaction Time; Restraint, Physical; Stress, Psychological | 1991 |
Conformational search in enkephalin analogues containing a disulfide bond.
Topics: Amino Acid Sequence; Disulfides; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Indoles; Models, Molecular; Molecular Sequence Data; Morphinans; Naltrexone; Protein Conformation; Thermodynamics | 1990 |
Supraspinal analgesic action of pentazocine in mice.
Topics: Analgesics; Animals; Drug Tolerance; Indoles; Injections, Intraventricular; Male; Mice; Morphinans; Naltrexone; Pain Measurement; Pentazocine; Receptors, Opioid; Time Factors | 1990 |
Effects of chronic treatment with specific antagonists on analgesia and physical dependence on morphine in rats.
Topics: Analgesics; Animals; Indoles; Male; Morphinans; Morphine Dependence; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Weight Loss | 1990 |
Apparent affinity of opioid antagonists in morphine-treated rhesus monkeys discriminating between saline and naltrexone.
Topics: Animals; Discrimination Learning; Dose-Response Relationship, Drug; Female; Indoles; Macaca mulatta; Morphinans; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, mu | 1990 |
Naltrindole 5'-isothiocyanate: a nonequilibrium, highly selective delta opioid receptor antagonist.
Topics: Affinity Labels; Animals; Chemical Phenomena; Chemistry; Isothiocyanates; Male; Mice; Morphinans; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Thiocyanates | 1990 |
Design of peptidomimetic delta opioid receptor antagonists using the message-address concept.
Topics: Animals; Computer Simulation; Drug Design; Guinea Pigs; In Vitro Techniques; Indoles; Mice; Morphinans; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Structure-Activity Relationship | 1990 |
Butorphanol, levallorphan, nalbuphine and nalorphine as antagonists in the squirrel monkey.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Butorphanol; Dose-Response Relationship, Drug; Levallorphan; Male; Methadone; Morphinans; Nalbuphine; Nalorphine; Naltrexone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Saimiri | 1990 |
A lack of potency for the delta-opioid antagonist naltrindole after microinjection into the rostral ventrolateral medulla of rabbits.
Topics: Animals; Blood Pressure; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Indoles; Male; Medulla Oblongata; Microinjections; Morphinans; Naltrexone; Narcotic Antagonists; Rabbits; Receptors, Opioid; Receptors, Opioid, delta | 1990 |
"Paradoxical" analgesia and aggravated morphine dependence induced by opioid antagonists.
Topics: Animals; Body Weight; Indoles; Male; Morphinans; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome; Substance-Related Disorders | 1990 |
Antagonism of swim-stress-induced antinociception by the delta-opioid receptor antagonist naltrindole in adult and young rats.
Topics: Aging; Animals; Animals, Newborn; Corticosterone; Indoles; Male; Morphinans; Naltrexone; Narcotic Antagonists; Nociceptors; Physical Exertion; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Stress, Psychological | 1990 |
Further evidence for the implication of a kappa-opioid receptor mechanism in the production of psychological stress-induced analgesia.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics; Animals; Benzomorphans; Drug Tolerance; Electroshock; Indoles; Male; Mice; Mice, Inbred Strains; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Stress, Psychological; Swimming | 1990 |
Differential effect of opioids on immunoglobulin production by lymphocytes isolated from Peyer's patches and spleen.
Topics: Adrenocorticotropic Hormone; Animals; Cells, Cultured; Concanavalin A; Endorphins; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Immunoglobulins; Indoles; Lymphocytes; Male; Mice; Mice, Inbred C57BL; Morphinans; Naltrexone; Narcotic Antagonists; Peyer's Patches; Receptors, Interleukin-2; Spleen; T-Lymphocytes | 1990 |
In vivo and in vitro investigation of naltrindole, a delta-opioid antagonist.
Topics: Animals; Dose-Response Relationship, Drug; Electric Stimulation; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Indoles; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphinans; Morphine; Muscle Contraction; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Reaction Time; Receptors, Opioid; Receptors, Opioid, delta; Vas Deferens | 1990 |
Centrally administered opioid antagonists, nor-binaltorphimine, 16-methyl cyprenorphine and MR2266, suppress intake of a sweet solution.
Topics: Animals; Benzomorphans; Drinking Behavior; Female; Glucose; Injections, Intraventricular; Morphinans; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Saccharin | 1990 |
Effects of kappa opioids on schedule-controlled behavior of squirrel monkeys.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzomorphans; Conditioning, Psychological; Dose-Response Relationship, Drug; Electroshock; Male; Morphinans; Morphine; Naltrexone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Saimiri | 1989 |
Estimation of affinities and efficacies for kappa-receptor agonists in guinea-pig ileum.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Binding, Competitive; Cyclazocine; Electric Stimulation; Ethylketocyclazocine; Guinea Pigs; In Vitro Techniques; Male; Models, Biological; Morphinans; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa | 1989 |
Modulation of appetitively and aversively motivated behavior by the kappa opioid antagonist MR2266.
Topics: Animals; Appetitive Behavior; Arousal; Avoidance Learning; Benzomorphans; Brain; Conditioning, Classical; Dose-Response Relationship, Drug; Drinking; Fear; Female; Injections, Intraventricular; Morphinans; Motivation; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1989 |
The therapeutic efficacy of opiate antagonists in hemorrhagic shock.
Topics: Animals; Dogs; Endorphins; Hemodynamics; Morphinans; Nalbuphine; Naloxone; Naltrexone; Shock, Hemorrhagic | 1989 |
Exploring delta-receptor function using the selective opioid antagonist naltrindole.
Topics: Animals; Behavior, Animal; Indoles; Male; Morphinans; Naltrexone; Narcotic Antagonists; Pain; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Stress, Psychological | 1989 |
Delta opioid receptor selective alkaloid agonists and antagonists.
Topics: Animals; Binding, Competitive; Guinea Pigs; Indoles; Mice; Morphinans; Naltrexone; Narcotic Antagonists; Narcotics; Nociceptors; Receptors, Opioid; Receptors, Opioid, delta; Structure-Activity Relationship | 1989 |
Adrenalectomy and the anorectic effects of benzodiazepine inverse agonists and opiate antagonists in rats fed a palatable diet.
Topics: Adrenal Glands; Adrenalectomy; Animals; Appetite; Appetite Depressants; Carbolines; Clonazepam; Diprenorphine; Eating; Hunger; Male; Morphinans; Naltrexone; Pyrazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A; Taste | 1987 |
Naltrindole, a highly selective and potent non-peptide delta opioid receptor antagonist.
Topics: Animals; Guinea Pigs; Ileum; In Vitro Techniques; Indoles; Male; Mice; Morphinans; Muscle Contraction; Muscle, Smooth, Vascular; Naltrexone; Narcotic Antagonists; Rats; Receptors, Opioid; Receptors, Opioid, delta; Vas Deferens | 1988 |
Estimation of opioid receptor agonist dissociation constants with beta-chlornaltrexamine, an irreversible ligand which also displays agonism.
Topics: Animals; Cyclazocine; Drug Interactions; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Ethylketocyclazocine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphinans; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1988 |
Cardiovascular responses to kappa opioid agonists in intact and adrenal demedullated rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenal Medulla; Animals; Benzomorphans; Blood Pressure; Cardiovascular System; Dose-Response Relationship, Drug; Heart Rate; Male; Morphinans; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rats; Rats, Inbred Strains; Tape Recording | 1988 |
Bremazocine is an agonist at kappa-opioid receptors and an antagonist at mu-opioid receptors in the guinea-pig myenteric plexus.
Topics: Animals; Benzomorphans; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Morphinans; Myenteric Plexus; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1986 |
Diprenorphine has agonist activity at opioid kappa-receptors in the myenteric plexus of the guinea-pig ileum.
Topics: Animals; Cricetinae; Diprenorphine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphinans; Muscle Contraction; Myenteric Plexus; Naltrexone; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vas Deferens | 1987 |
Ethylketocyclazocine and bremazocine analgesia in neonatal rats.
Topics: Analgesia; Analgesics; Animals; Animals, Newborn; Benzomorphans; Cyclazocine; Ethylketocyclazocine; Female; Male; Morphinans; Naltrexone; Narcotic Antagonists; Rats | 1988 |
Reversal by beta-funaltrexamine and 16-methyl cyprenorphine of the antinociceptive effects of opioid agonists in the mouse and guinea-pig.
Topics: Abdomen; Animals; Guinea Pigs; Male; Mice; Morphinans; Muscle Contraction; Naltrexone; Narcotic Antagonists; Narcotics; Nociceptors; Pain | 1988 |
Internally standardized method for the determination of nalbuphine in human plasma by means of high performance liquid chromatography with electrochemical coulometric detection.
Topics: Chromatography, High Pressure Liquid; Electrochemistry; Humans; Indicators and Reagents; Morphinans; Nalbuphine; Naltrexone; Quality Control; Reference Standards | 1988 |
Immobilization of white-tailed deer by etorphine and xylazine and its antagonism by nalmefene and yohimbine.
Topics: Anesthesia, General; Anesthesia, Intravenous; Animals; Deer; Etorphine; Female; Immobilization; Injections, Intramuscular; Male; Morphinans; Naltrexone; Thiazines; Xylazine; Yohimbine | 1987 |
Effects of morphine, naltrexone, and dextrorphan in untreated and morphine-treated pigeons.
Topics: Animals; Behavior, Animal; Body Weight; Columbidae; Conditioning, Operant; Dextrorphan; Dose-Response Relationship, Drug; Drug Tolerance; Morphinans; Morphine; Naloxone; Naltrexone; Stereoisomerism | 1985 |
Treatment of experimental stroke with opiate antagonists. Effects on neurological function, infarct size, and survival.
Topics: Animals; Brain Ischemia; Cats; Cerebrovascular Disorders; Consciousness; Diprenorphine; Disease Models, Animal; Male; Morphinans; Movement; Naloxone; Naltrexone; Pupil; Sensation | 1986 |
Effects of naloxone and other opiate antagonists on blood-ethanol concentration in acutely-ethanol-intoxicated rats.
Topics: Alcoholic Intoxication; Animals; Benzomorphans; Ethanol; Humans; Male; Morphinans; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Time Factors | 1985 |
Effects of buprenorphine on shock titration in squirrel monkeys.
Topics: Animals; Buprenorphine; Conditioning, Operant; Diprenorphine; Dose-Response Relationship, Drug; Drug Interactions; Electroshock; Male; Morphinans; Morphine; Naloxone; Naltrexone; Saimiri | 1985 |
Stereospecificity of 4,5-epoxymorphinan binding to the lambda site in rat brain.
Topics: Animals; Binding, Competitive; Brain; In Vitro Techniques; Male; Morphinans; Morphine; Naloxone; Naltrexone; Narcotics; Oxymorphone; Rats; Rats, Inbred Strains; Receptors, Opioid; Stereoisomerism | 1984 |
Prevention of late fentanyl-induced respiratory depression after the injection of opiate antagonists naltrexone and S-20682: comparison with naloxone.
Topics: Animals; Carbon Dioxide; Depression, Chemical; Dogs; Electroencephalography; Fentanyl; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Oxygen; Partial Pressure; Respiration; Time Factors | 1983 |
Effects of three narcotic antagonists (naltrexone, diprenorphine, and S-20682) on blood pressure, heart rate and electrical cortical activity.
Topics: Animals; Blood Pressure; Carbon Dioxide; Cerebral Cortex; Diprenorphine; Dogs; Electroencephalography; Electrophysiology; Heart Rate; Morphinans; Naltrexone; Narcotic Antagonists; Respiration | 1983 |
Discriminative stimulus effects of reversible and irreversible opiate agonists: morphine, oxymorphazone and buprenorphine.
Topics: Animals; Buprenorphine; Columbidae; Discrimination Learning; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Hydromorphone; Morphinans; Morphine; Naltrexone; Oxymorphone; Time Factors | 1984 |
Irreversible and reversible narcotic agonists: discriminative and analgesic effects of buprenorphine, oxymorphazone, and morphine.
Topics: Animals; Buprenorphine; Columbidae; Discrimination Learning; Dose-Response Relationship, Drug; Hydromorphone; Mice; Morphinans; Morphine; Naltrexone; Nociceptors; Oxymorphone | 1984 |
A novel opioid receptor site directed alkylating agent with irreversible narcotic antagonistic and reversible agonistic activities.
Topics: Alkylating Agents; Animals; Guinea Pigs; In Vitro Techniques; Morphinans; Muscle Contraction; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Narcotics; Oxymorphone; Receptors, Opioid | 1980 |
Seasonal variation in the apparent number of binding sites for 3H-opioid agonists and antagonists.
Topics: Animals; Binding Sites; Brain; Dihydromorphine; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Kinetics; Male; Mice; Morphinans; Morphine; Naloxone; Naltrexone; Receptors, Opioid; Seasons | 1981 |
In vivo receptor binding of the opiate partial agonist, buprenorphine, correlated with its agonistic and antagonistic actions.
Topics: Analgesia; Animals; Brain; Buprenorphine; Dose-Response Relationship, Drug; Male; Morphinans; Morphine; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid | 1981 |
Repeated administration of naltrexone and diprenorphine decreases food intake and body weight in squirrel monkeys.
Topics: Animals; Body Weight; Diprenorphine; Dose-Response Relationship, Drug; Drinking; Eating; Female; Humans; Male; Morphinans; Naloxone; Naltrexone; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Saimiri; Salivation | 1984 |
Endogenous opiates and stress. Behavioral activation elicited in the rat and effects of naltrexone, diprenorphine and morphine.
Topics: Animals; Behavior, Animal; Diprenorphine; Endorphins; Humans; Male; Morphinans; Morphine; Naloxone; Naltrexone; Noise; Rats; Rats, Inbred Strains; Receptors, Drug; Stress, Psychological; Time Factors | 1984 |
Patterns of drinking in the rat following the administration of opiate antagonists.
Topics: Animals; Depression, Chemical; Diprenorphine; Drinking Behavior; Male; Morphinans; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Water Deprivation | 1983 |
Discriminative stimulus effects of dextrorphan in pigeons.
Topics: Animals; Bemegride; Binding Sites; Columbidae; Dextrorphan; Dioxolanes; Discrimination Learning; Dose-Response Relationship, Drug; Drug Interactions; Generalization, Stimulus; Morphinans; Naltrexone; Pentobarbital; Piperidines; Stereoisomerism; Structure-Activity Relationship | 1983 |
Nalmefene: quantitation of a new narcotic antagonist in human plasma using high performance-liquid chromatography with electrochemical detection.
Topics: Chromatography, High Pressure Liquid; Electrochemistry; Humans; Kinetics; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Time Factors | 1983 |
Clinical pharmacology of mixed agonist-antagonist drugs [proceedings].
Topics: Buprenorphine; Cyclazocine; Humans; Methadone; Morphinans; Morphine Dependence; Naltrexone | 1981 |
Tonic modulation of neurotransmitter release in the guinea-pig myenteric plexus: effect of mu and kappa opioid receptor blockade and of chronic sympathetic denervation.
Topics: Acetylcholine; Animals; Colon; Dose-Response Relationship, Drug; Guinea Pigs; Morphinans; Myenteric Plexus; Naltrexone; Narcotic Antagonists; Neurotransmitter Agents; Norepinephrine; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sympathetic Nervous System | 1995 |
The use of specific opioid agonists and antagonists to delineate the vagally mediated antinociceptive and cardiovascular effects of intravenous morphine.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analysis of Variance; Animals; Blood Pressure; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Heart Rate; Hexamethonium; Hexamethonium Compounds; Indoles; Injections, Intravenous; Male; Morphinans; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pain; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reference Values; Time Factors; Vagotomy; Vagus Nerve | 1993 |
A remarkable change of opioid receptor selectivity on the attachment of a peptidomimetic kappa address element to the delta antagonist, natrindole: 5'-[N2-alkylamidino)methyl]naltrindole derivatives as a novel class of kappa opioid receptor antagonists.
Topics: Animals; Guinea Pigs; Indoles; Morphinans; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Receptors, Opioid, kappa; Structure-Activity Relationship | 1993 |
Blockade of delta-opioid receptors in the nucleus accumbens prevents ethanol-induced stimulation of dopamine release.
Topics: Animals; Cocaine; Dopamine; Ethanol; Indoles; Male; Morphinans; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta | 1993 |
Opioid-induced stimulation of fetal respiratory activity by [D-Ala2]deltorphin I.
Topics: Animals; Dose-Response Relationship, Drug; Electromyography; Female; Fetus; Indoles; Injections, Intraventricular; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pregnancy; Receptors, Opioid, delta; Respiration; Sheep | 1993 |
Electrophysiological actions of delta opioids in CA1 of the rat hippocampal slice are mediated by one delta receptor subtype.
Topics: Analgesics; Animals; Electric Stimulation; Electrophysiology; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Evoked Potentials; Hippocampus; In Vitro Techniques; Indoles; Ligands; Male; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Pyramidal Tracts; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu | 1993 |
Evidence for a single functional opioid delta receptor subtype in the mouse isolated vas deferens.
Topics: Animals; Benzylidene Compounds; Drug Tolerance; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; In Vitro Techniques; Isothiocyanates; Male; Mice; Mice, Inbred ICR; Morphinans; Naltrexone; Oligopeptides; Receptors, Opioid, delta; Thiocyanates; Vas Deferens | 1993 |
Naltrindole, an opioid delta receptor antagonist, blocks cocaine-induced facilitation of responding for rewarding brain stimulation.
Topics: Analysis of Variance; Animals; Brain; Cocaine; Electric Stimulation; Indoles; Male; Morphinans; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Reinforcement, Psychology; Self Stimulation | 1993 |
Immunosuppression by delta opioid receptor antagonist.
Topics: Animals; Fluorescent Antibody Technique; Graft Survival; Immunosuppressive Agents; Indoles; Kidney Transplantation; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Lymphocytes; Morphinans; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred BN; Rats, Inbred Lew; Receptors, Opioid, delta; Spleen; Time Factors; Transplantation, Homologous | 1993 |
Cocaine-like discriminative stimulus properties of the delta-selective opioid receptor agonist, [D-Pen2,L-Pen5]enkephalin, in the rat.
Topics: Animals; Cocaine; Discrimination Learning; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Generalization, Stimulus; Indoles; Morphinans; Naltrexone; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu | 1993 |
Quantitative light microscopic localization of [3H]naltrindole binding sites in the rat brain.
Topics: Animals; Autoradiography; Binding Sites; Brain Chemistry; In Vitro Techniques; Indoles; Male; Microscopy; Morphinans; Naltrexone; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Tritium | 1993 |
Involvement of delta 2 opioid receptors in the development of morphine dependence in mice.
Topics: Animals; Enkephalin, Leucine; Isothiocyanates; Male; Mice; Morphinans; Morphine Dependence; Naloxone; Naltrexone; Receptors, Opioid, delta; Substance Withdrawal Syndrome; Thiocyanates | 1993 |
Opioid antagonists and butorphanol dependence.
Topics: Animals; Behavior, Animal; Butorphanol; Indoles; Injections, Intraventricular; Male; Morphinans; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Substance Withdrawal Syndrome | 1993 |
Involvement of mu1 and mu2 opioid receptor subtypes in tail-pinch feeding in rats.
Topics: Animals; Arousal; Enkephalin, Leucine-2-Alanine; Feeding Behavior; Indoles; Male; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 1993 |
[3H]naltrindole: a potent and selective ligand for labeling delta-opioid receptors.
Topics: Animals; Binding, Competitive; Brain; Indoles; Kinetics; Male; Morphinans; Naltrexone; Narcotic Antagonists; Narcotics; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Thermodynamics; Tritium | 1993 |
(D-Ala, D-Leu) enkephalin reduces the binding of GTP in hippocampal membranes.
Topics: Affinity Labels; Animals; Autoradiography; Azides; Electrophoresis, Polyacrylamide Gel; Enkephalin, Leucine-2-Alanine; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Hippocampus; In Vitro Techniques; Indoles; Male; Membranes; Morphinans; Naltrexone; Rats; Rats, Sprague-Dawley | 1993 |
The influence of opioid antagonists on the discriminative stimulus effects of ethanol.
Topics: Animals; Discrimination, Psychological; Dose-Response Relationship, Drug; Ethanol; Male; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar | 1996 |
Activation of mu-opioid receptors are required for the conditioned enhancement of NK cell activity.
Topics: Animals; beta-Endorphin; Enkephalin, Leucine; Enkephalin, Methionine; Injections, Spinal; Killer Cells, Natural; Mice; Mice, Inbred BALB C; Morphinans; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu | 1996 |
Characterization of opiate binding sites on the goldfish (Carassius auratus L.) pronephric leukocytes.
Topics: Animals; Binding Sites; Goldfish; Leukocytes; Morphinans; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Receptors, Opioid, mu | 1997 |
Synthesis, opioid receptor binding, and bioassay of naltrindole analogues substituted in the indolic benzene moiety.
Topics: Animals; Brain; Guinea Pigs; Ileum; Indoles; Ligands; Male; Mice; Morphinans; Muscle Contraction; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship; Vas Deferens | 1998 |
Synthesis of 7-arylmorphinans. Probing the "address" requirements for selectivity at opioid delta receptors.
Topics: Animals; Electric Stimulation; Guinea Pigs; Ileum; In Vitro Techniques; Ligands; Male; Mice; Models, Molecular; Molecular Conformation; Morphinans; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Oxymorphone; Pain Measurement; Receptors, Opioid, delta; Spiro Compounds; Vas Deferens | 1998 |
Relationship between inhibitory effect of endogenous opioid via mu-receptors and muscarinic autoinhibition in acetylcholine release from myenteric plexus of guinea pig ileum.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetylcholine; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Atropine; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphinans; Muscarine; Muscarinic Agonists; Muscarinic Antagonists; Muscle, Smooth; Myenteric Plexus; Naltrexone; Narcotic Antagonists; Opioid Peptides; Receptors, Muscarinic; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1998 |
Mutational evidence for a common kappa antagonist binding pocket in the wild-type kappa and mutant mu[K303E] opioid receptors.
Topics: Amino Acid Sequence; Animals; Binding, Competitive; COS Cells; Guanidines; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Models, Molecular; Molecular Conformation; Molecular Sequence Data; Morphinans; Muscle, Smooth; Mutation; Naltrexone; Narcotic Antagonists; Rats; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vas Deferens | 1998 |
Interactions between cholecystokinin and opioids in the isolated guinea-pig ileum.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphinans; Muscle Contraction; Naloxone; Naltrexone; Oligopeptides; Opioid Peptides; Receptor, Cholecystokinin A; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Receptors, Opioid; Sincalide; Substance Withdrawal Syndrome | 1999 |
Synthesis, opioid receptor binding, and biological activities of naltrexone-derived pyrido- and pyrimidomorphinans.
Topics: Analgesics; Animals; Binding, Competitive; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Ileum; Male; Mice; Mice, Inbred Strains; Morphinans; Morphine; Muscle Contraction; Naltrexone; Protein Binding; Rats; Receptors, Opioid; Vas Deferens | 1999 |
Use of selective antagonists and antisense oligonucleotides to evaluate the mechanisms of BUBU antinociception.
Topics: Analgesics; Animals; Male; Mice; Morphinans; Naltrexone; Narcotic Antagonists; Oligonucleotides, Antisense; Oligopeptides; Pain Measurement; Receptors, Opioid, delta; Receptors, Opioid, mu | 1999 |
5'-Guanidinonaltrindole, a highly selective and potent kappa-opioid receptor antagonist.
Topics: Animals; CHO Cells; Cricetinae; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Guanidines; Guinea Pigs; Humans; In Vitro Techniques; Ligands; Male; Membranes; Mice; Mice, Inbred ICR; Morphinans; Muscle, Smooth; Naltrexone; Receptors, Opioid, kappa | 2000 |
Potent and selective indolomorphinan antagonists of the kappa-opioid receptor.
Topics: Cell Line; Guanidines; Humans; Indoles; Models, Molecular; Morphinans; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Receptors, Opioid, kappa; Structure-Activity Relationship; Transfection | 2000 |
The novel kappa-opioid receptor agonist TRK-820 suppresses the rewarding and locomotor-enhancing effects of morphine in mice.
Topics: Animals; Dose-Response Relationship, Drug; Male; Mice; Morphinans; Morphine; Motor Activity; Naltrexone; Narcotics; Receptors, Opioid, kappa; Reward; Spiro Compounds | 2001 |
TRK-820, a selective kappa-opioid agonist, produces potent antinociception in cynomolgus monkeys.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Behavior, Animal; Macaca fascicularis; Morphinans; Morphine; Naloxone; Naltrexone; Pain Measurement; Pentazocine; Pentobarbital; Receptors, Opioid, kappa; Spiro Compounds | 2001 |
The kappa-opioid antagonist GNTI reduces U50,488-, DAMGO-, and deprivation-induced feeding, but not butorphanol- and neuropeptide Y-induced feeding in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Brain; Butorphanol; Drug Interactions; Eating; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Food Deprivation; Guanidines; Male; Morphinans; Naltrexone; Narcotic Antagonists; Narcotics; Neuropeptide Y; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa | 2001 |
Mu- and delta-opioid receptor antagonists reduce levodopa-induced dyskinesia in the MPTP-lesioned primate model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Callithrix; Disease Models, Animal; Drug Therapy, Combination; Dyskinesias; Female; Hypokinesia; Levodopa; Male; Morphinans; Motor Activity; Naltrexone; Narcotic Antagonists; Parkinsonian Disorders; Posture; Receptors, Opioid, delta; Receptors, Opioid, mu | 2001 |
[(11)C]-GR89696, a potent kappa opiate receptor radioligand; in vivo binding of the R and S enantiomers.
Topics: Adrenergic alpha-Agonists; Animals; Brain; Mice; Morphinans; Naltrexone; Narcotic Antagonists; Piperazines; Pyrrolidines; Receptors, Opioid, kappa; Stereoisomerism; Tissue Distribution | 2002 |
Antipruritic activity of the kappa-opioid receptor agonist, TRK-820.
Topics: Animals; Antipruritics; Chlorpheniramine; Disease Models, Animal; Histamine; Histamine H1 Antagonists; Ketotifen; Male; Mice; Mice, Inbred ICR; Morphinans; Motor Activity; Naltrexone; Pruritus; Receptors, Opioid, kappa; Spiro Compounds; Substance P | 2002 |
Kappa opioid antagonist effects of the novel kappa antagonist 5'-guanidinonaltrindole (GNTI) in an assay of schedule-controlled behavior in rhesus monkeys.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Non-Narcotic; Animals; Benzamides; Benzeneacetamides; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Interactions; Female; Guanidines; Macaca mulatta; Male; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Piperazines; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Reinforcement Schedule; Time Factors | 2002 |
Synthesis, opioid receptor binding, and functional activity of 5'-substituted 17-cyclopropylmethylpyrido[2',3':6,7]morphinans.
Topics: Animals; Brain Chemistry; Guanidines; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Ileum; In Vitro Techniques; Indicators and Reagents; Male; Morphinans; Muscle Contraction; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Pyridines; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship; Vas Deferens | 2003 |
Blockade of mu-opioid receptor-mediated G-protein activation and antinociception by TRK-820 in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; GTP-Binding Proteins; In Vitro Techniques; Injections, Intraventricular; Medulla Oblongata; Mice; Morphinans; Naltrexone; Narcotic Antagonists; Pain Measurement; Pons; Radioligand Assay; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spiro Compounds | 2003 |
Activation of delta- and kappa-opioid receptors by opioid peptides protects cardiomyocytes via KATP channels.
Topics: Adenosine Triphosphate; Animals; Benzamides; Cardiotonic Agents; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, Methionine; Guanidines; Ischemic Preconditioning, Myocardial; Male; Mitochondria; Morphinans; Myocardial Ischemia; Myocytes, Cardiac; Naltrexone; Narcotic Antagonists; Potassium Channels; Rabbits; Receptors, Opioid, delta; Receptors, Opioid, kappa; Sarcolemma | 2003 |
Involvement of central mu-opioid system in the scratching behavior in mice, and the suppression of it by the activation of kappa-opioid system.
Topics: Animals; Antipruritics; Behavior, Animal; Injections, Intraventricular; Injections, Subcutaneous; Ketotifen; Male; Mice; Morphinans; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Pruritus; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spiro Compounds; Substance P | 2003 |
Region-dependent G-protein activation by kappa-opioid receptor agonists in the mouse brain.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzeneacetamides; Brain; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice; Morphinans; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid, kappa; Spiro Compounds | 2004 |
Effects of substitution on the pyrrole N atom in derivatives of tetrahydronaltrindole, tetrahydrooxymorphindole, and a related 4,5-epoxyphenylpyrrolomorphinan.
Topics: Analgesics; Animals; Binding, Competitive; CHO Cells; Cricetinae; Cricetulus; Humans; Indoles; Ligands; Morphinans; Naltrexone; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship | 2004 |
Spontaneous scratching behavior in MRL/lpr mice, a possible model for pruritus in autoimmune diseases, and antipruritic activity of a novel kappa-opioid receptor agonist nalfurafine hydrochloride.
Topics: Age Factors; Animals; Antipruritics; Autoimmune Diseases; Behavior, Animal; Chlorpheniramine; Dermis; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Immunoglobulin E; Immunoglobulin G; Male; Mice; Mice, Inbred ICR; Mice, Inbred MRL lpr; Mice, Inbred Strains; Morphinans; Naltrexone; Pruritus; Receptors, Opioid, kappa; Sex Factors; Spiro Compounds | 2005 |
Antinociception, tolerance and withdrawal symptoms induced by 7-hydroxymitragynine, an alkaloid from the Thai medicinal herb Mitragyna speciosa.
Topics: Analgesics; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Injections, Subcutaneous; Male; Mice; Mitragyna; Models, Molecular; Morphinans; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Reaction Time; Secologanin Tryptamine Alkaloids; Substance Withdrawal Syndrome; Thailand | 2005 |
Molecular modeling and 3D-QSAR studies of indolomorphinan derivatives as kappa opioid antagonists.
Topics: Amino Acid Sequence; Animals; Cattle; Conserved Sequence; Guanidine; Guanidines; Humans; In Vitro Techniques; Indoles; Models, Molecular; Molecular Sequence Data; Morphinans; Naltrexone; Protein Conformation; Quantitative Structure-Activity Relationship; Receptors, Opioid, kappa; Rhodopsin; Sequence Homology, Amino Acid | 2006 |
Effects of the local administration of selective mu-, delta-and kappa-opioid receptor agonists on osteosarcoma-induced hyperalgesia.
Topics: Analgesics, Opioid; Animals; Bone Neoplasms; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Hyperalgesia; Mice; Morphinans; Naltrexone; Narcotic Antagonists; Osteosarcoma; Receptors, Opioid | 2005 |
Endogenous dynorphin in epileptogenesis and epilepsy: anticonvulsant net effect via kappa opioid receptors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzamides; Cell Count; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Epilepsy, Temporal Lobe; Guanidines; Hippocampus; Kindling, Neurologic; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphinans; Naltrexone; Nerve Degeneration; Piperazines; Protein Precursors; Receptors, Opioid, kappa; Synaptic Transmission; Time Factors | 2007 |
Pharmacological properties of bivalent ligands containing butorphan linked to nalbuphine, naltrexone, and naloxone at mu, delta, and kappa opioid receptors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; CHO Cells; Cricetinae; Cricetulus; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Ligands; Morphinans; Nalbuphine; Naloxone; Naltrexone; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship | 2007 |
Comparison of the opioid receptor antagonist properties of naltrexone and 6 beta-naltrexol in morphine-naïve and morphine-dependent mice.
Topics: Animals; Binding, Competitive; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred ICR; Morphinans; Morphine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Narcotics; Pain Measurement; Pyrroles; Receptors, Opioid, mu; Substance Withdrawal Syndrome | 2008 |
Synthesis and biological evaluation of alpha- and beta-6-amido derivatives of 17-cyclopropylmethyl-3, 14beta-dihydroxy-4, 5alpha-epoxymorphinan: potential alcohol-cessation agents.
Topics: Alcohol Drinking; Alcoholism; Amides; Animals; Binding, Competitive; Drug Evaluation, Preclinical; Ethanol; Humans; Hydrogen Bonding; Liver; Mice; Microsomes, Liver; Molecular Structure; Morphinans; Naltrexone; Rats; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stereoisomerism; Structure-Activity Relationship | 2008 |
In vivo characterization of (-)(-)MCL-144 and (+)(-)MCL-193: isomeric, bivalent ligands with mu/kappa agonist properties.
Topics: Alkanes; Analgesics; Animals; Brain; CHO Cells; Cricetinae; Cricetulus; Fumarates; Guanosine 5'-O-(3-Thiotriphosphate); Half-Life; Male; Morphinans; Morphine; Naltrexone; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stereoisomerism | 2008 |
Roles of opioid receptor subtypes on the antinociceptive effect of intrathecal sildenafil in the formalin test of rats.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Interactions; Guanidines; Male; Morphinans; Naltrexone; Narcotic Antagonists; Pain Measurement; Pain Threshold; Phosphodiesterase Inhibitors; Piperazines; Purines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Sildenafil Citrate; Somatostatin; Sulfones; Time Factors | 2008 |
Synthesis of N-isobutylnoroxymorphone from naltrexone by a selective cyclopropane ring opening reaction.
Topics: Acetic Acid; Analgesics, Opioid; Animals; Cyclopropanes; Dose-Response Relationship, Drug; Mice; Molecular Structure; Morphinans; Naltrexone; Receptors, Opioid | 2008 |
Prodynorphin-derived peptides are critical modulators of anxiety and regulate neurochemistry and corticosterone.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amygdala; Animals; Anxiety; Brain Stem; Corticosterone; Corticotropin-Releasing Hormone; Dynorphins; Enkephalins; Exploratory Behavior; Female; Guanidines; Hypothalamus; Male; Maze Learning; Mesencephalon; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphinans; Naltrexone; Neuropeptide Y; Neuropeptides; Protein Precursors; Raphe Nuclei; Receptors, Opioid, kappa; Stress, Psychological | 2009 |
Design, synthesis, and biological evaluation of 6alpha- and 6beta-N-heterocyclic substituted naltrexamine derivatives as mu opioid receptor selective antagonists.
Topics: Amino Acid Sequence; Analgesics; Analgesics, Opioid; Animals; Binding Sites; Binding, Competitive; CHO Cells; Cricetinae; Cricetulus; Drug Design; Ligands; Models, Molecular; Molecular Sequence Data; Morphinans; Morphine; Naltrexone; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sequence Alignment; Structure-Activity Relationship | 2009 |
Design and synthesis of novel delta opioid receptor agonists and their pharmacologies.
Topics: Drug Design; Morphinans; Naltrexone; Receptors, Opioid, delta | 2009 |
Effects of TRK-820, a selective kappa opioid receptor agonist, on rat schizophrenia models.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Dopamine; Extracellular Space; Hyperkinesis; Male; Morphinans; Naltrexone; Phencyclidine; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Schizophrenia; Serotonin; Spiro Compounds | 2009 |
Nalfurafine prevents 5'-guanidinonaltrindole- and compound 48/80-induced spinal c-fos expression and attenuates 5'-guanidinonaltrindole-elicited scratching behavior in mice.
Topics: Afferent Pathways; Analgesics, Opioid; Animals; Antipruritics; Biomarkers; Disease Models, Animal; Guanidines; Male; Mice; Morphinans; Naltrexone; Narcotic Antagonists; Nociceptors; p-Methoxy-N-methylphenethylamine; Pain Measurement; Posterior Horn Cells; Proto-Oncogene Proteins c-fos; Pruritus; Receptors, Opioid, kappa; Sensory Receptor Cells; Spinal Cord; Spiro Compounds; Treatment Outcome | 2009 |
Inhibitory effect of lidocaine on pain and itch using formalin-induced nociception and 5'-guanidinonaltrindole-induced scratching models in mice: behavioral and neuroanatomical evidence.
Topics: Animals; Behavior, Animal; Formaldehyde; Gene Expression Regulation; Guanidines; Lidocaine; Male; Mice; Morphinans; Naltrexone; Neurons; Pain; Proto-Oncogene Proteins c-fos; Pruritus; Receptors, Opioid, kappa | 2009 |
Study of a structurally similar kappa opioid receptor agonist and antagonist pair by molecular dynamics simulations.
Topics: Binding Sites; Guanidines; Ligands; Models, Molecular; Molecular Dynamics Simulation; Morphinans; Naltrexone; Protein Structure, Tertiary; Receptors, Opioid, kappa | 2010 |
Investigation of gastrin-releasing peptide as a mediator for 5'-guanidinonaltrindole-induced compulsive scratching in mice.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Bombesin; Compulsive Behavior; Ganglia, Spinal; Gastrin-Releasing Peptide; Grooming; Guanidines; Locomotion; Male; Mice; Morphinans; Naltrexone; Nerve Fibers; Peptide Fragments; Pirenzepine; Pruritus; Receptor, Muscarinic M1; Receptors, Bombesin; Receptors, Opioid, kappa; Skin; Spinal Cord; Spiro Compounds | 2011 |
Micro-opioid receptor activation in the basolateral amygdala mediates the learning of increases but not decreases in the incentive value of a food reward.
Topics: Amygdala; Animals; Conditioning, Operant; Drive; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Food; Guanidines; Male; Microinjections; Morphinans; Naltrexone; Narcotic Antagonists; Neuropsychological Tests; Rats; Rats, Long-Evans; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reward; Somatostatin; Sucrose | 2011 |
Opioid-like compound exerts anti-fibrotic activity via decreased hepatic stellate cell activation and inflammation.
Topics: Actins; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Proliferation; Cell Survival; Cells, Cultured; Chemical and Drug Induced Liver Injury; Collagen; Disease Models, Animal; Hepatic Stellate Cells; Immunoblotting; Liver Cirrhosis; Male; Matrix Metalloproteinase 13; Matrix Metalloproteinase 2; Morphinans; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred WKY; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction | 2011 |
The novel δ opioid receptor agonist KNT-127 produces antidepressant-like and antinociceptive effects in mice without producing convulsions.
Topics: Analgesics; Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Behavior, Animal; Benzamides; Depression; Dopamine Antagonists; Imipramine; Male; Mice; Mice, Inbred ICR; Morphinans; Motor Activity; Naltrexone; Narcotic Antagonists; Pain Measurement; Piperazines; Receptors, Opioid, delta; Seizures; Swimming | 2011 |
Synthesis of novel triplet drugs with 1,3,5-trioxazatriquinane skeletons and their pharmacologies. 1: Synthesis of triplet drugs with morphinan skeletons.
Topics: Analgesics; Bridged-Ring Compounds; Dose-Response Relationship, Drug; Molecular Structure; Morphinans; Naltrexone; Receptors, Opioid, mu | 2011 |
Preclinical disposition (in vitro) of novel μ-opioid receptor selective antagonists.
Topics: Absorption; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood-Brain Barrier; Caco-2 Cells; Cell Line, Tumor; Glucuronides; Humans; Intestinal Absorption; Metabolic Detoxication, Phase I; Microsomes, Liver; Morphinans; Naltrexone; Narcotic Antagonists; Protein Binding; Receptors, Opioid, mu | 2011 |
Opioid-like antinociceptive effects of oral administration of a lectin purified from the seeds of Canavalia brasiliensis.
Topics: Administration, Oral; Analgesics; Analgesics, Opioid; Animals; Canavalia; Mice; Morphinans; Naloxone; Naltrexone; Nociception; Pain Measurement; Plant Lectins; Receptors, Opioid, delta; Receptors, Opioid, kappa; Seeds | 2013 |
Early role of the κ opioid receptor in ethanol-induced reinforcement.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Central Nervous System Depressants; Conditioning, Classical; Dose-Response Relationship, Drug; Ethanol; Female; Guanidines; Male; Morphinans; Motor Activity; Naltrexone; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reinforcement, Psychology | 2012 |
Structure of the human κ-opioid receptor in complex with JDTic.
Topics: Binding Sites; Crystallography, X-Ray; Diterpenes, Clerodane; Guanidines; Humans; Models, Molecular; Morphinans; Mutagenesis, Site-Directed; Naltrexone; Piperidines; Protein Conformation; Receptors, Adrenergic, beta-2; Receptors, CXCR4; Receptors, Opioid, kappa; Structure-Activity Relationship; Tetrahydroisoquinolines | 2012 |
Structural biology: How opioid drugs bind to receptors.
Topics: Animals; Biomimetic Materials; Humans; Morphinans; Naltrexone; Nociceptin Receptor; Opioid Peptides; Piperidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spiro Compounds; Tetrahydroisoquinolines | 2012 |
Long-acting κ opioid antagonists nor-BNI, GNTI and JDTic: pharmacokinetics in mice and lipophilicity.
Topics: Animals; Biological Transport; Brain; Guanidines; Hydrophobic and Hydrophilic Interactions; Injections, Intraperitoneal; LLC-PK1 Cells; Male; Mice; Morphinans; Naltrexone; Narcotic Antagonists; Permeability; Piperidines; Receptors, Opioid, kappa; Swine; Tetrahydroisoquinolines | 2012 |
Analgesic properties of chimeric peptide based on morphiceptin and PFRTic-amide.
Topics: Analgesia; Analgesics, Opioid; Animals; Arginine; Dose-Response Relationship, Drug; Endorphins; Guinea Pigs; Male; Mice; Morphinans; Naloxone; Naltrexone; Neuropeptides; Opioid Peptides; Proline; Receptors, Neuropeptide; Tetrahydroisoquinolines; Time Factors | 2012 |
The cardiovascular effects of a chimeric opioid peptide based on morphiceptin and PFRTic-NH2.
Topics: Analgesics, Opioid; Animals; Blood Pressure; Bradycardia; Endorphins; Heart Rate; Hypotension; Injections, Intravenous; Injections, Intraventricular; Male; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; NG-Nitroarginine Methyl Ester; Rats; Rats, Wistar | 2013 |
Different types of opioid receptors involved in the suppression of LH secretion in lactating sheep.
Topics: Animals; Female; Gene Expression Regulation; Guanidines; Lactation; Luteinizing Hormone; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Sheep | 2013 |
Selective κ opioid antagonists nor-BNI, GNTI and JDTic have low affinities for non-opioid receptors and transporters.
Topics: Allosteric Regulation; Biological Transport; Caco-2 Cells; Calcium; Guanidines; Humans; Kinetics; Morphinans; Naltrexone; Narcotic Antagonists; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Piperidines; Protein Binding; Receptors, Adrenergic, alpha; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tetrahydroisoquinolines | 2013 |
DOR(2)-selective but not DOR(1)-selective antagonist abolishes anxiolytic-like effects of the δ opioid receptor agonist KNT-127.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Benzylidene Compounds; Exploratory Behavior; Formaldehyde; Male; Maze Learning; Morphinans; Naltrexone; Narcotic Antagonists; Neuropsychological Tests; Nociception; Rats; Rats, Wistar; Receptors, Opioid, delta | 2014 |
Characterization of BU09059: a novel potent selective κ-receptor antagonist.
Topics: Animals; Cell Line, Tumor; CHO Cells; Cricetulus; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Guanidines; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Isoquinolines; Male; Mice; Mice, Inbred Strains; Molecular Structure; Morphinans; Naltrexone; Narcotic Antagonists; Nociception; Piperidines; Rats; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tetrahydroisoquinolines; Vas Deferens | 2014 |
Drug effects on multiple and concurrent schedules of ethanol- and food-maintained behaviour: context-dependent selectivity.
Topics: Alcoholism; Amphetamines; Animals; Chlordiazepoxide; Dextroamphetamine; Dose-Response Relationship, Drug; Drug Administration Schedule; Eating; Ethanol; Food; Male; Morphinans; Naltrexone; Piperazines; Rats; Rats, Inbred Lew | 2014 |
Potent inhibition of alcohol self-administration in alcohol-preferring rats by a κ-opioid receptor antagonist.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Conditioning, Operant; Ethanol; Male; Morphinans; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Self Administration; Thioamides | 2014 |
GI relief may come sooner than later for patients with chronic noncancer pain.
Topics: Adult; Analgesics, Opioid; Chronic Pain; Constipation; Drug Approval; Humans; Morphinans; Naltrexone; Narcotic Antagonists; Polyethylene Glycols; Quaternary Ammonium Compounds; United States; United States Food and Drug Administration | 2014 |
Structure-Activity Relationships of (+)-Naltrexone-Inspired Toll-like Receptor 4 (TLR4) Antagonists.
Topics: Analgesics, Opioid; Animals; Cell Line; Drug Synergism; Humans; Lipopolysaccharides; Male; Microglia; Morphinans; Morphine; Naltrexone; Nitric Oxide; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Toll-Like Receptor 4 | 2015 |
Investigation of the role of βarrestin2 in kappa opioid receptor modulation in a mouse model of pruritus.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Arrestins; beta-Arrestins; Chloroquine; Disease Models, Animal; Dose-Response Relationship, Drug; Guanidines; Isoquinolines; Male; Mice, Inbred C57BL; Mice, Knockout; Morphinans; Motor Activity; Naltrexone; Pruritus; Receptors, Opioid, kappa | 2015 |
Synthesis and characterization of a dual kappa-delta opioid receptor agonist analgesic blocking cocaine reward behavior.
Topics: Analgesics, Opioid; Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Psychological; Dopamine Uptake Inhibitors; Drug Evaluation, Preclinical; Male; Mice, Inbred C57BL; Mice, Knockout; Molecular Structure; Morphinans; Naltrexone; Nociception; Nuclear Receptor Subfamily 1, Group F, Member 1; Random Allocation; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reward; Spatial Behavior | 2015 |
Role of µ, κ, and δ opioid receptors in tibial inhibition of bladder overactivity in cats.
Topics: Acetic Acid; Animals; Cats; Female; Male; Morphinans; Naloxone; Naltrexone; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tibial Nerve; Transcutaneous Electric Nerve Stimulation; Urinary Bladder, Overactive | 2015 |
Brain opioid and nociceptin receptors are involved in regulation of bombesin-induced activation of central sympatho-adrenomedullary outflow in the rat.
Topics: Adrenal Medulla; Animals; Bombesin; Brain; Catecholamines; Morphinans; Naloxone; Naltrexone; Nociceptin Receptor; Rats; Receptors, Opioid; Sympathetic Nervous System | 2016 |
Opioid-Induced Constipation Part 2: Newer Therapies #295.
Topics: Analgesics, Opioid; Constipation; Humans; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Polyethylene Glycols; Quaternary Ammonium Compounds | 2015 |
Molecular switches of the κ opioid receptor triggered by 6'-GNTI and 5'-GNTI.
Topics: Allosteric Regulation; Amino Acid Motifs; Analgesics, Opioid; Cations, Monovalent; Gene Expression; Guanidines; Humans; Hydrogen Bonding; Ligands; Molecular Docking Simulation; Molecular Dynamics Simulation; Morphinans; Mutation; Naltrexone; Narcotic Antagonists; Protein Interaction Domains and Motifs; Protein Structure, Secondary; Receptors, Opioid, kappa; Recombinant Proteins; Sodium | 2016 |
Synthesis and evaluation of novel opioid ligands with a C-homomorphinan skeleton.
Topics: Analgesics, Opioid; Animals; Benzylidene Compounds; CHO Cells; Cricetulus; Humans; Ligands; Models, Molecular; Morphinans; Naltrexone; Narcotic Antagonists; Quinolines; Receptors, Opioid; Receptors, Opioid, delta; Structure-Activity Relationship | 2016 |
The anxiolytic- and antidepressant-like effects of ATPM-ET, a novel κ agonist and μ partial agonist, in mice.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Avoidance Learning; Emotions; Exploratory Behavior; Hindlimb Suspension; Locomotion; Mice; Morphinans; Naltrexone; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2016 |
A role for the mu opioid receptor in the antidepressant effects of buprenorphine.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Buprenorphine; Feeding and Eating Disorders; Feeding Behavior; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphinans; Naltrexone; Narcotic Antagonists; Pain Measurement; Reaction Time; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2017 |
Naloxegol, an opioid antagonist with reduced CNS penetration: Mode-of-action and human relevance for rat testicular tumours.
Topics: Animals; Biomarkers; Blood-Brain Barrier; Capillary Permeability; Dogs; Female; Humans; Leydig Cell Tumor; Luteinizing Hormone; Male; Mice; Morphinans; Naltrexone; Narcotic Antagonists; Polyethylene Glycols; Quaternary Ammonium Compounds; Rabbits; Rats, Sprague-Dawley; Risk Assessment; Species Specificity; Testicular Neoplasms; Testosterone; Time Factors; Toxicity Tests; Up-Regulation | 2017 |
κ-Opioid Receptor Activation in Dopamine Neurons Disrupts Behavioral Inhibition.
Topics: Animals; Behavior, Animal; Compulsive Behavior; Disease Models, Animal; Dopaminergic Neurons; Dorsal Raphe Nucleus; Female; Inhibition, Psychological; Male; Mice; Mice, Inbred C57BL; Morphinans; Naltrexone; Narcotic Antagonists; Prefrontal Cortex; Receptors, Opioid, kappa; Reinforcement, Psychology; Spiro Compounds; Stress, Psychological; Ventral Tegmental Area | 2018 |
Understanding the molecular basis of agonist/antagonist mechanism of human mu opioid receptor through gaussian accelerated molecular dynamics method.
Topics: Amino Acid Motifs; Catalytic Domain; Humans; Models, Molecular; Molecular Dynamics Simulation; Morphinans; Naltrexone; Normal Distribution; Protein Binding; Protein Conformation; Pyrroles; Receptors, Opioid, mu | 2017 |
Administration of a delta opioid receptor agonist KNT-127 to the basolateral amygdala has robust anxiolytic-like effects in rats.
Topics: Amygdala; Animals; Anti-Anxiety Agents; Anxiety; Anxiety Disorders; Basolateral Nuclear Complex; Fear; Learning; Male; Morphinans; Muscimol; Naltrexone; Rats; Rats, Wistar; Receptors, Opioid, delta | 2018 |
A delta opioid receptor agonist, KNT-127, in the prelimbic medial prefrontal cortex attenuates glial glutamate transporter blocker-induced anxiety-like behavior in mice.
Topics: Amino Acid Transport System X-AG; Animals; Anti-Anxiety Agents; Anxiety; Aspartic Acid; Drug Interactions; gamma-Aminobutyric Acid; Glutamic Acid; Male; Mice; Microinjections; Morphinans; Naltrexone; Prefrontal Cortex; Receptors, Opioid, delta | 2018 |
Antagonism of μ-opioid receptors reduces sensation seeking-like behavior in mice.
Topics: Animals; Appetitive Behavior; Brain; Conditioning, Operant; Dose-Response Relationship, Drug; Exploratory Behavior; Male; Mice, Inbred C57BL; Morphinans; Motivation; Motor Activity; Naltrexone; Narcotic Antagonists; Random Allocation; Receptors, Opioid; Receptors, Opioid, mu; Reward | 2019 |
Possible involvement of the μ opioid receptor in the antinociception induced by sinomenine on formalin-induced nociceptive behavior in mice.
Topics: Administration, Oral; Analgesics; Animals; Dose-Response Relationship, Drug; Formaldehyde; Male; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morphinans; Naloxone; Naltrexone; Nociception; Receptors, Opioid, mu; Spinal Cord | 2019 |
Suppression of Human Natural Killer Cells by Different Classes of Opioids.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Anesthesia; Buprenorphine; Enkephalin, D-Penicillamine (2,5)-; Fentanyl; Fluoresceins; Humans; Immunosuppression Therapy; K562 Cells; Killer Cells, Natural; Loperamide; Methadone; Morphinans; Morphine; Naloxone; Naltrexone; Succinimides; Toll-Like Receptor 4; Tramadol | 2019 |
Combination of Clinically Utilized Kappa-Opioid Receptor Agonist Nalfurafine With Low-Dose Naltrexone Reduces Excessive Alcohol Drinking in Male and Female Mice.
Topics: Alcohol Deterrents; Alcohol Drinking; Alcohol-Related Disorders; Animals; Drug Evaluation, Preclinical; Drug Tolerance; Female; Male; Mice, Inbred C57BL; Morphinans; Naltrexone; Receptors, Opioid, kappa; Saccharin; Spiro Compounds; Sucrose | 2019 |
Clinically utilized kappa-opioid receptor agonist nalfurafine combined with low-dose naltrexone prevents alcohol relapse-like drinking in male and female mice.
Topics: Alcohol Drinking; Alcoholism; Analgesics, Opioid; Animals; Drinking; Ethanol; Female; Male; Mice; Mice, Inbred C57BL; Morphinans; Naltrexone; Narcotic Antagonists; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recurrence; Secondary Prevention; Spiro Compounds | 2019 |
Selective agonists of the δ-opioid receptor, KNT-127 and SNC80, act differentially on extinction learning of contextual fear memory in mice.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Benzamides; Conditioning, Psychological; Extinction, Psychological; Fear; Learning; Male; Memory; Mice; Morphinans; Motor Activity; Naltrexone; Piperazines; Receptors, Opioid, delta | 2019 |
Medical Management of Opioid-Induced Constipation.
Topics: Analgesics, Opioid; Humans; Laxatives; Lubricants; Morphinans; Naltrexone; Narcotic Antagonists; Opioid-Induced Constipation; Polyethylene Glycols | 2019 |
Kappa opioid agonists reduce oxycodone self-administration in male rhesus monkeys.
Topics: Analgesics, Opioid; Animals; Behavior, Addictive; Cocaine; Diterpenes, Clerodane; Dose-Response Relationship, Drug; Macaca mulatta; Male; Morphinans; Naltrexone; Narcotic Antagonists; Oxycodone; Receptors, Opioid, kappa; Reinforcement, Psychology; Self Administration; Spiro Compounds | 2020 |
Structure-Activity Relationship between Thiol Group-Trapping Ability of Morphinan Compounds with a Michael Acceptor and Anti-
Topics: Antimalarials; Benzylidene Compounds; Humans; Morphinans; Naltrexone; Nuclear Magnetic Resonance, Biomolecular; Plasmodium falciparum; Structure-Activity Relationship | 2020 |
Naloxegol rescue with methylnaltrexone highly effective.
Topics: Analgesics, Opioid; Female; Humans; Middle Aged; Morphinans; Naltrexone; Narcotic Antagonists; Opioid-Induced Constipation; Palliative Care; Polyethylene Glycols; Quality of Life; Quaternary Ammonium Compounds | 2020 |
The blockade of kappa opioid receptors exacerbates alveolar bone resorption in rats.
Topics: Alveolar Bone Loss; Animals; Bone Resorption; Cytokines; Disease Models, Animal; Male; Morphinans; Naltrexone; Narcotic Antagonists; Osteoblasts; Osteoclasts; Periodontitis; Rats; Rats, Wistar; Receptors, Opioid | 2020 |
A low pKa ligand inhibits cancer-associated pain in mice by activating peripheral mu-opioid receptors.
Topics: Analgesics, Opioid; Animals; Bone Neoplasms; Cancer Pain; Cell Line, Tumor; Fentanyl; Hydrogen-Ion Concentration; Hyperalgesia; Ligands; Male; Melanoma, Experimental; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Piperidines; Receptors, Opioid, mu | 2020 |
Effects of kappa opioid receptor agonists on fentanyl vs. food choice in male and female rats: contingent vs. non-contingent administration.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Female; Fentanyl; Male; Morphinans; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reinforcement, Psychology; Spiro Compounds | 2021 |
A selective delta opioid receptor agonist SNC80, but not KNT-127, induced tremor-like behaviors via hippocampal glutamatergic system in mice.
Topics: Analgesics, Opioid; Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Behavior, Animal; Benzamides; Hippocampus; Insular Cortex; Mice; Morphinans; Motor Activity; Naltrexone; Piperazines; Receptors, Opioid, delta | 2021 |
Exploring the putative mechanism of allosteric modulations by mixed-action kappa/mu opioid receptor bitopic modulators.
Topics: Allosteric Regulation; Allosteric Site; Binding Sites; Humans; Ligands; Molecular Docking Simulation; Morphinans; Naltrexone; Protein Binding; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spiro Compounds; Thermodynamics | 2021 |
Factors associated with non-response to naldemedine for opioid-induced constipation in cancer patients: A subgroup analysis.
Topics: Analgesics, Opioid; Constipation; Gastrointestinal Agents; Humans; Morphinans; Naltrexone; Narcotic Antagonists; Neoplasms; Opioid-Induced Constipation; Quality of Life; Retrospective Studies | 2022 |
A MOR Antagonist with High Potency and Antagonist Efficacy among Diastereomeric C9-Alkyl-Substituted
Topics: Analgesics, Opioid; Morphinans; Morphine; Naltrexone; Receptors, Opioid, mu; Structure-Activity Relationship | 2023 |