naltrexone has been researched along with methylnaltrexone in 289 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 41 (14.19) | 18.7374 |
| 1990's | 34 (11.76) | 18.2507 |
| 2000's | 77 (26.64) | 29.6817 |
| 2010's | 117 (40.48) | 24.3611 |
| 2020's | 20 (6.92) | 2.80 |
| Authors | Studies |
|---|---|
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Bidlack, JM; Bu, Y; Cohen, DJ; Denhardt, C; Ganorkar, R; Guo, C; Jin, J; Lou, R; Lu, Q; VanAlstine, MA; Wentland, MP | 1 |
| Akbarali, HI; Akubathini, SK; Beletskaya, IO; Chen, J; Dewey, WL; Elbegdorj, O; Gerk, PM; Scoggins, KL; Selley, DE; Stevens, DL; Yuan, Y; Zhang, F; Zhang, Y; Zhang, Z | 1 |
| Brockmöller, J; Friesacher, HR; Meyer, MJ; Neumann, VE; Tzvetkov, MV; Zdrazil, B | 1 |
| Bersh, PJ; Blustein, JE; Calcagnetti, DJ; Margules, DL; Troisi, JR; Whitehouse, WG | 1 |
| Luecken, LJ; Lysle, DT; Maslonek, KA | 1 |
| Katafuchi, T; Koizumi, K; Nagatomo, I | 1 |
| Cappell, H; Lê, AD; Poulos, CX; Walker, MJ | 1 |
| Banks, WA; Kastin, AJ; Pearson, MA | 1 |
| Fletcher, PJ | 1 |
| Leander, JD; Mayer-Valkanover, K; Nussbaumer, C; Schmidhammer, H; Schmidt, C; Schoepp, DD; Schratz, A; Walla-Kugler, M | 1 |
| Brodish, A; Odio, M | 1 |
| Ghanta, VK; Hiramoto, RN; Solvason, HB | 1 |
| Belluzzi, JD; Stein, L; Trujillo, KA | 1 |
| Calcagnetti, DJ; Fanselow, MS; Jalowiec, JE | 1 |
| Burton, E; Goldberg, LI; Kotake, AN; Kuwahara, SK; McCoy, CE | 1 |
| DiBona, GF; Jones, SY; Kapusta, DR | 1 |
| Mucha, RF | 2 |
| Bechara, A; van der Kooy, D | 1 |
| Linseman, MA | 1 |
| Calcagnetti, DJ; Fanselow, MS; Helmstetter, FJ | 1 |
| Baratti, CM | 1 |
| Bechara, A; van der Kooy, D; Zito, KA | 1 |
| Burks, TF; Fox, DA | 1 |
| Emmanouil, DE; Ishii, MM; Quock, RM | 1 |
| Misra, AL; Pontani, RB; Vadlamani, NL | 1 |
| Bansinath, M; Bhargava, HN | 1 |
| Baratti, CM; Introini, IB; McGaugh, JL | 1 |
| Holtzman, SG; Locke, KW | 1 |
| van der Kooy, D | 1 |
| Blank, MS; Daugherty, DT; Mann, DR; Murphy, JR; Sridiran, R | 1 |
| Franklin, KB; Kelly, SJ | 1 |
| Corrigall, WA; D'Onofrio, RM; Lei, H; Linseman, MA | 1 |
| Corrigall, WA; Vaccarino, FJ | 2 |
| Bechara, A; Martin, GM; van der Kooy, D | 1 |
| Bhargava, HN; Ramarao, P | 1 |
| Adams, JU; France, CP; Woods, JH | 1 |
| Abhold, R; Kalivas, PW | 1 |
| Corrigall, WA | 1 |
| Borrell, J; Fuentes, JA; Naranjo, JR; Urdín, MC | 1 |
| Kanarek, RB; Marks-Kaufman, R; Plager, A | 1 |
| Fries, DS; Kouchich, FJ; Quock, RM; Vaughn, LK | 1 |
| Galbraith, JA; Mickley, GA; Stevens, KE | 1 |
| Borrell, J; Fuentes, JA; Naranjo, JR | 1 |
| Amir, S; Harel, M | 1 |
| Brown, DR; Chang, EB; Field, M; Miller, RJ | 1 |
| Argentieri, TM; McArdle, JJ | 1 |
| Brown, DR; Goldberg, LI; Robertson, MJ | 1 |
| Bloom, FE; Ettenberg, A; Koob, GF; Pettit, HO | 1 |
| Carr, KD; Simon, EJ | 1 |
| Brown, DR; Holtzman, SG | 1 |
| Dickson, PR; Vaccarino, FJ | 1 |
| Foss, JF; Moss, J; Yuan, CS | 1 |
| Kapusta, DR; Obih, JC | 1 |
| Amin, HM; Camporesi, EM; Esposito, BF; Foss, JF; Roizen, MF; Sopchak, AM | 1 |
| Akinbami, MA; Collins, DC; Mann, DR; Taylor, MF | 1 |
| Bass, AS; Foss, JF; Goldberg, LI | 1 |
| Foss, JF; Moss, J; O'Connor, M; Roizen, MF; Toledano, A; Yuan, CS | 1 |
| Camu, F; Franck, P; Moerman, I | 1 |
| Foss, JF; Goldberg, LI; Orelind, E | 1 |
| Kameyama, T; Kobayashi, T; Shan-Wu, X; Ukai, M | 1 |
| Foss, JF; Moss, J; Murphy, M; O'Connor, MF; Roizen, MF; Yuan, CS | 1 |
| Foss, JF; Moss, J; Osinski, J; Roizen, MF; Toledano, A; Yuan, CS | 1 |
| Rosow, CE | 1 |
| Murphy, DB; Murphy, MB; Prescott, LF; Sutton, JA | 1 |
| Andrić, S; Kostić, T; Kovacević, R; Marić, D | 2 |
| Bedingfield, JB; Holloway, FA | 1 |
| Lysle, DT; Schneider, GM | 1 |
| Foss, JF; Goldberg, LI; Roizen, MF; Yuan, CS | 1 |
| Foss, JF; Moss, J; O'Connor, M; Osinski, J; Roizen, MF; Yuan, CS | 1 |
| Murphy, DB; Murphy, MB | 1 |
| How, T; Lysle, DT | 1 |
| Foss, JF; Yuan, CS | 2 |
| Foss, FJ; Moss, J; O'Connor, M; Osinski, J; Roizen, FM; Yuan, SC | 1 |
| Izzo, E; King, M; Koob, GF; Pasternak, GW; Walker, JR | 1 |
| Foss, JF; Karrison, T; Moss, J; O'Connor, M; Osinski, J; Roizen, MF; Yuan, CS | 2 |
| McNally, GP; Westbrook, RF | 1 |
| Fujimoto, JM; Holmes, BB; Portoghese, PS; Rady, JJ | 1 |
| Scholz, M | 1 |
| Lysle, DT; Nelson, CJ; Schneider, GM | 1 |
| Dello Buono, FA; Friedman, JD | 1 |
| Lysle, DT; Nelson, CJ | 1 |
| Chan, VW; El Behiery, H; Foss, JF; Murph, DB | 1 |
| Foss, JF; Karrison, T; O'Connor, M; Osinski, J; Wei, G; Yuan, CS | 1 |
| Pappagallo, M | 1 |
| Foss, JF | 1 |
| Moss, J; Yuan, CS | 1 |
| Stephenson, J | 1 |
| Fujimura, T; Hayashi, T; Kastin, AJ; Murayama, K; Sakurada, C; Sakurada, S; Sakurada, T; Sato, T; Takeshita, M; Yonezawa, A; Yuhki, M; Zadina, JE | 1 |
| De Ponti, F | 1 |
| Foss, JF; Osinski, J; Wang, A; Wu, JA; Yuan, CS | 1 |
| Kurz, A; Sessler, DI | 1 |
| Douglas, SD; Guo, CJ; Ho, WZ; Moss, J; Yuan, CS | 1 |
| Izenwasser, S; Platt, DM; Rowlett, JK; Spealman, RD | 1 |
| Aung, HH; Mehendale, SR; Moss, J; Xie, JT; Yuan, CS | 1 |
| Holzer, P | 3 |
| Charney, MR; Doshan, H; Israel, RJ; Karrison, T; Maleckar, SA; Moss, J; O'connor, M; Yuan, CS | 1 |
| Boscan, PL; van Hoogmoed, LM | 1 |
| Sinatra, RS | 1 |
| Carter, S | 1 |
| Saclarides, TJ | 1 |
| Israel, RJ; Yuan, CS | 1 |
| Boscan, P; Farver, TB; Pypendop, BH; Snyder, JR; Van Hoogmoed, LM | 1 |
| Dehaven-Hudkins, DL; Fukuda, H; Hicks, GA; Mantyh, CR; Pappas, TN; Suenaga, K; Takahashi, T; Tsuchida, D | 1 |
| Thompson, CA | 2 |
| Beattie, DT; Cheruvu, M; Johnson-Rabidoux, S; Kaufman, E; Mai, N; O'Keefe, M; Peterson, C; Vickery, R | 1 |
| Chen, TY; Gomery, P; Israel, R; Rosow, CE; Stambler, N; Stefanovich, P | 1 |
| Garcia, JG; Moreno-Vinasco, L; Moss, J; Sammani, S; Singleton, PA; Wanderling, SL | 1 |
| Yuan, CS | 1 |
| Friedman, D; Jahdi, M; Rim, F; Shaiova, L | 1 |
| Thomas, J | 1 |
| Jackson, KC; Neyens, R | 1 |
| DeHaven, RN; DeHaven-Hudkins, DL; Little, PJ; Techner, LM | 1 |
| Conzen, PF; Reichle, FM | 1 |
| Boyce, D; Carr, DB; McNicol, ED; Schumann, R | 1 |
| Galasso, FL; Israel, RJ; Moehl Boatwright, ML; Portenoy, RK; Stambler, N; Thomas, J; Tran, D; Von Gunten, CF | 1 |
| Traynor, K | 1 |
| Chamberlain, BH; Cooney, GA; Israel, RJ; Karver, S; Kremer, AB; Slatkin, NE; Stambler, N; Thomas, J; Watt, CK | 1 |
| Berde, C; Nurko, S | 1 |
| Lang, L | 1 |
| Garcia, JG; Moss, J; Singleton, PA | 1 |
| Kraft, MD | 1 |
| del Valle Rivero, ML; Sanz Rubiales, A | 1 |
| Chappell, D; Conzen, P; Rehm, M | 1 |
| Meerpohl, JJ; Timmer, A | 1 |
| Moss, J; O'Connor, M; Woo, M; Yuan, CS | 1 |
| Carrillo, F; Johnson, J; Laustsen, G; Smith, C | 1 |
| Becker, G; Blum, HE | 1 |
| Belavic, JM | 1 |
| Kast, RE | 1 |
| Cannom, RR; Mason, RJ | 1 |
| Delaney, CP; Stulberg, JJ; Zeinali, F | 1 |
| Guay, DR | 1 |
| Hussar, DA | 1 |
| Frost, EA | 1 |
| Lux, EA | 1 |
| Beijnen, JH; Hendrikx, JJ; Schellens, JH | 1 |
| Aung, HH; Li, XL; McEntee, E; Sun, S; Tong, R; Wang, CZ; Xie, JT; Yuan, CS | 1 |
| Chappell, D; Conzen, P | 1 |
| Chamberlain, BH; Cross, K; Israel, RJ; Su, C; Thomas, J; Wang, W; Winston, JL | 1 |
| Atayee, R; Diego, L; Helmons, P; von Gunten, CF | 1 |
| Baker, DE | 1 |
| Chandrasekaran, A; DeMaio, W; Erve, JC; Goljer, I; Hultin, T; Li, H; McConnell, O; Rotshteyn, Y; Scatina, J; Talaat, R; Tong, Z | 1 |
| Kyle, G | 1 |
| Earnshaw, SR; Iyer, S; Klok, RM; McDade, C | 1 |
| Ladanyi, A; Moss, J; Temkin, SM | 1 |
| Chandrasekaran, A; Demaio, W; Erve, JC; Hultin, T; Li, H; Rotshteyn, Y; Scatina, J; Talaat, R; Tong, Z | 1 |
| Kapoor, S | 1 |
| Garnock-Jones, KP; McKeage, K | 1 |
| Avigan, M; Green, L; Greene, P; Mackey, AC | 1 |
| Leppert, W | 1 |
| Baumrucker, SJ; Licup, N | 1 |
| Berbari, J; Farah, B; Iskedjian, M; Iyer, S; Librach, SL; Wang, M | 1 |
| Burton, DD; Busciglio, I; Camilleri, M; Manabe, N; McKinzie, S; Rao, AS; Ryks, M; Wong, BS; Zinsmeister, AR | 1 |
| Janssen, P; Pottel, H; Tack, J; Vos, R | 1 |
| Iyer, SS; Manley, AL; Randazzo, BP; Schulman, SL; Tzanis, EL; Wang, W; Zhang, H | 1 |
| Boyd, TA; Rotshteyn, Y; Yuan, CS | 1 |
| Candy, B; Drake, R; Goodman, ML; Jones, L; Tookman, A | 1 |
| Bührer, C; Degenhardt, P; Garten, L | 1 |
| Blonsky, ER; Iyer, S; Manley, A; Michna, E; Randazzo, B; Schulman, S; Tzanis, E; Zhang, H | 1 |
| Carpenito, J; Chun, HK; Randazzo, B; Schulman, S; Stambler, N; Tzanis, E; Yu, CS | 1 |
| Byfieldt, N; Clark, K; Currow, DC; Dawe, M | 1 |
| Cooney, GA; Israel, RJ; Karver, S; Lipman, AG; Stambler, N | 1 |
| Hagemann, TM; Miller, JL | 1 |
| Duerden, M; Manley, A; Michna, E; Randazzo, B; Schulman, S; Tzanis, E; Wang, W; Weil, AJ; Yu, D; Zhang, H | 1 |
| Lee, JM; Mooney, J | 1 |
| Oswald, S; Schumacher, G; Siegmund, W | 1 |
| Hales, TG | 1 |
| Anissian, L; Carpenito, J; Ramakrishna, T; Schwartz, HW; Stambler, N; Vincent, HK; Vincent, K | 1 |
| Bührer, C; Garten, L | 1 |
| Israel, RJ; Lynn, R; Slatkin, NE; Su, C; Wang, W | 1 |
| Cayley, WE | 1 |
| Fleckenstein, J; Napadow, V; Nowak-Machen, M; Pfab, F | 1 |
| Gibson, PR; Morrison, G | 1 |
| Magnuson, B; Thompson, M | 1 |
| Cotton, AL; Danga, A; Moss, J; Patel, PB; Sawh, SB; Selvaraj, IP | 1 |
| Gatti, A; Sabato, AF | 1 |
| Heintz, J; Kissling, KT; Mohassel, LR | 1 |
| Baker, JN; Coleman, JL; Johnson, LM; Spraker, HL | 1 |
| Clark, K; Currow, DC; Robinson, MK; Rowett, DS | 1 |
| Kong, F; Marquez, B; Nguyen, B; Pagano, TG; Pan, W; Tsao, R; Zhu, T | 1 |
| Bloom, A; Gras, B; Lembo, A; Magge, S | 1 |
| Gu, M; Lin, DH; McEntee, E; Qin, LF; Wang, CZ; Wang, JT; Xie, XX; Yuan, CS | 1 |
| Chapman, MJ; Deane, AM; Nguyen, NQ | 1 |
| Anselmi, L; Huynh, J; Sternini, C; Vegezzi, G | 1 |
| Brick, N | 1 |
| Bailey, A; Garg, N; Kumar, N | 1 |
| Clemens, KE; Faust, M; Jaspers, B; Mikus, G | 1 |
| Armstrong, SR; Beattie, DT; Long, DD; Tsuruda, PR; Vickery, RG | 1 |
| Ahlstrand, R; Magnuson, A; Savilampi, J; Wattwil, M | 1 |
| Baker, JN; Laubisch, JE | 1 |
| Brenner, DM; Ford, AC; Schoenfeld, PS | 1 |
| Alexander, S; Dupuis, LL; Lau, E; Mattiussi, A; Rodrigues, A; Wong, C | 1 |
| McCarberg, BH | 1 |
| Fringer, A; Ivanovi, N; Lötscher, C | 1 |
| Wang, CZ; Yuan, CS | 1 |
| Rauck, RL | 1 |
| Stettler, A; Zulian, GB | 1 |
| Müller-Lissner, S | 1 |
| Hellwig, TR; Pottebaum, AA | 1 |
| Barnett, V; Mihalyo, M; Twycross, R; Wilcock, A | 1 |
| Amini, A; Asadi, S; Farbood, A; Zand, F | 1 |
| Clark, K; Currow, DC; Robinson, M; Rowett, D | 1 |
| Chohan, O; Mayer, A; Yeomanson, D | 1 |
| Barrett, AC; Bortey, E; Forbes, WP; Nalamachu, SR; Paterson, C; Pergolizzi, J; Slatkin, NE; Taylor, R; Yu, J | 1 |
| Coalson, DW; Wroblewski, K; Zacny, JP | 1 |
| Jagla, C; Martus, P; Stein, C | 1 |
| Rodriguez, RW | 1 |
| Schairer, J; Thapa, SD | 1 |
| Carvalho, B; Nathan, E; Ng, L; Paech, M; Sia, A; Sng, B | 1 |
| Brokjaer, A; Christrup, LL; Dahan, A; Drewes, AM; Olesen, AE | 1 |
| Aoyagi, K; Ashikawa, M; Chiwaki, F; Fujita, T; Fukagawa, T; Katai, H; Komatsu, M; Kushima, R; Nagase, H; Nakagama, H; Narita, M; Sakamoto, H; Sasaki, H; Sawada, Y; Suzuki, M; Suzuki, T; Uezono, Y; Yanagihara, K; Yoshida, T | 1 |
| Battista, V; Santucci, G | 1 |
| Baker, JN; Flerlage, JE | 1 |
| Candy, B; Jones, L; Larkin, PJ; Stone, P; Tookman, A; Vickerstaff, V | 1 |
| Barrett, AC; Bull, J; Forbes, WP; Israel, RJ; Paterson, C; Wellman, CV | 1 |
| Atkins, JT; Janku, F; Karp, DD; Moss, J; Singleton, PA | 1 |
| Goumon, Y; Khabbazi, S; Parat, MO | 1 |
| Backstedt, D; Jones, R; Prommer, E | 1 |
| Harlos, MS; Hohl, CM; Wong, JK | 1 |
| Kolbow, J; Maritz, MA; Modess, C; Oswald, S; Rey, H; Siegmund, W; Wegner, D; Weitschies, W | 1 |
| Ahmedzai, SH; Boland, JW | 1 |
| Badke, A; Rosielle, DA | 1 |
| Weber, HC | 1 |
| Baqai, A; Diwan, S; Giambrone, GP; Mehta, N; O'Connell, K | 1 |
| Fernández, SN; Fernández-Llamazares, C; González, R; López, J; López-Herce, J; Santiago, MJ; Urbano, J | 1 |
| Anjum, A; Brett, SJ; Cross, M; Gordon, AC; O'Callaghan, D; Patel, PB; Warwick, J | 2 |
| Bridgeman, MB; Chokhavatia, S; Dixit, D; John, ES | 1 |
| Atkins, JT; Janku, F; Johnson, LK; Karp, DD; Moss, J; Singleton, PA | 1 |
| Ades, S; Ashikaga, T; Ji, Y; Kumar, S; Mori, M | 1 |
| Harper, JR; Israel, RJ; Rauck, R; Slatkin, NE; Stambler, N | 1 |
| Barres, BA; Bohlen, CJ; Clark, JD; Corder, G; Dickinson, JR; Low, SA; Scherrer, G; Sotoudeh, C; Sypek, EI; Tawfik, VL; Wang, D | 1 |
| Pauwels, A; Rommel, N; Scarpellini, E; Tack, J; Vos, R | 1 |
| Altshuler, D; Merchan, C; Papadopoulos, J | 1 |
| Brooks, EP; Martin-Flores, M; Mitchell, LM; Singh, B; Taylor, L; Walsh, CA | 1 |
| Wirz, S | 1 |
| Andersson, H; Floettmann, E; Johnson, N; Mitchard, T | 1 |
| Korobov, MV; Lishmanov, YB; Maslov, LN; Naryzhnaya, NV; Tsibul'nikov, SY | 1 |
| Harper, JR; Israel, RJ; Khan, A; Michna, E; Webster, LR | 1 |
| Murphy, JA; Sheridan, EA | 1 |
| Bach-Rojecky, L; Drinovac Vlah, V; Filipović, B; Lacković, Z | 1 |
| Bobrovskaya, L; Senthilkumaran, M | 1 |
| Ahrens, B; Kucherova, Y; Sobolevsky, T | 1 |
| Afshari, K; Daneshpazhooh, M; Dehpour, AR; Foroutan, A; Haddadi, NS; Ostadhadi, S; Shakiba, S | 1 |
| Garcia, JM; Shamliyan, TA | 1 |
| Candy, B; Jones, L; Larkin, PJ; Stone, P; Vickerstaff, V | 2 |
| Abdollahi, M; Mozaffari, S; Nikfar, S | 1 |
| Akbarali, HI; Dewey, WL; Komla, E; Obeng, S; Selley, DE; Stevens, DL; Wang, H; Zhang, Y; Zheng, Y | 1 |
| Blackney, KA; Edwards, DA; Kamdar, NV; Liu, CA | 1 |
| Corsetti, M; Pannemans, J | 1 |
| Moss, J | 1 |
| Beeker, A; Berkhof, J; Neefjes, ECW; Rhodius, CA; Ten Oever, D; van den Berg, HP; van der Vliet, HJ; van der Vorst, MJDL; van der Wijngaart, H; Verheul, HMW | 1 |
| Mendelsohn, RB; Nelson, KK; Schattner, MA | 1 |
| Jilma, B; Schoergenhofer, C | 1 |
| Angiolillo, DJ; Bass, TA; Been, L; Faz, G; Franchi, F; Hu, J; Kureti, M; Park, Y; Pineda, AM; Rivas Rios, J; Rollini, F; Soffer, D; Suryadevara, S; Yaranov, D; Zenni, MM | 1 |
| Chamberlain, BH; Israel, RJ; Rhiner, M; Slatkin, NE; Stambler, N | 1 |
| Chamie, K; Faiena, I; Golla, V; Johnson, DC; Lec, PM; Lee, C; Lenis, AT; Rahman, S | 1 |
| Ahlström, FHG; Blomqvist, KJ; Dudek, KA; Kalso, EA; Laitila, J; Lilius, TO; Mätlik, K; Rauhala, PV; Viisanen, H | 1 |
| Brocklebank, J; Fingas, S; Miller, EJ | 1 |
| Akbarali, HI; Beardsley, PM; Komla, E; Moisa, LT; Mustafa, MA; Poklis, JL; Walentiny, DM | 1 |
| Brenner, DM; Coluzzi, PH; Israel, RJ; Slatkin, NE; Stambler, N | 1 |
| Liao, SS; Slatkin, NE; Stambler, N | 1 |
| Cata, JP; Corrales, G; Gleber-Netto, FO; Gorur, A; Myers, JN; Patiño, M; Pickering, C; Rangel, R; Shi, T; Takahashi, H | 1 |
| Cajander, P; Cock, C; Magnuson, A; Omari, T; Savilampi, J; Scheinin, M | 1 |
| Farhadi, HF; Gifford, CS; McGahan, BG; Minnema, AJ; Miracle, SD; Murphy, CV; Vazquez, DE; Weaver, TE | 2 |
| Israel, RJ; Mehta, N; Slatkin, NE; Stambler, N | 1 |
| Atchison, L; Beavers, J; Dennis, B; Guillamondegui, O; Medvecz, A; Orton, L; Smith, MC | 1 |
| Israel, RJ; Peacock, WF; Slatkin, NE; Stambler, N | 1 |
| Cook, ME; Drewes, AM; Fjelsted, CA; Frøkjær, JB; Hansen, MB; Knoph, CS; Mortensen, MB; Nielsen, LBJ; Novovic, S; Olesen, SS | 1 |
| Argente Navarro, MP; Belltall, A; Diaz-Cambronero, O; Eroles, P; Mazzinari, G | 1 |
| Brenner, D; Israel, RJ; Slatkin, NE; Stambler, N; Webster, LR | 1 |
| DeGrado, JR; Dube, KM; Goodberlet, MZ; Habeeb, EA; Lupi, KE; Tran, LK | 1 |
65 review(s) available for naltrexone and methylnaltrexone
| Article | Year |
|---|---|
Hyperalgesic functions of peripheral opiate receptors.
Topics: Analgesia; Animals; Autoradiography; Blood-Brain Barrier; Capsaicin; Electrophysiology; Etorphine; Ganglia, Spinal; Naltrexone; Narcotics; Neurons, Afferent; Peripheral Nerves; Quaternary Ammonium Compounds; Rats; Receptors, Opioid; Skin; Vagotomy; Vagus Nerve | 1986 |
Opioid antagonists in the treatment of opioid-induced constipation and pruritus.
Topics: Clinical Trials as Topic; Constipation; Humans; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pruritus; Quaternary Ammonium Compounds | 2001 |
Incidence, prevalence, and management of opioid bowel dysfunction.
Topics: Analgesics, Opioid; Cathartics; Colic; Constipation; Data Collection; Gastroesophageal Reflux; Humans; Incidence; Intestines; Naltrexone; Narcotic Antagonists; Prevalence; Quaternary Ammonium Compounds; United States | 2001 |
A review of the potential role of methylnaltrexone in opioid bowel dysfunction.
Topics: Analgesics, Opioid; Animals; Constipation; Dose-Response Relationship, Drug; Gastrointestinal Motility; Gastrointestinal Transit; Humans; Intestines; Morphine; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Receptors, Opioid | 2001 |
Methylnaltrexone Progenics.
Topics: Analgesics, Opioid; Animals; Constipation; Humans; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Randomized Controlled Trials as Topic; Structure-Activity Relationship | 2002 |
Opioid-induced bowel dysfunction: pathophysiology and potential new therapies.
Topics: Constipation; Digestive System; Gastrointestinal Motility; Gastrointestinal Transit; Humans; Intestinal Obstruction; Naltrexone; Narcotic Antagonists; Narcotics; Postoperative Complications; Quaternary Ammonium Compounds; Receptors, Opioid; Water-Electrolyte Balance | 2003 |
Opioids and opioid receptors in the enteric nervous system: from a problem in opioid analgesia to a possible new prokinetic therapy in humans.
Topics: Analgesics, Opioid; Animals; Constipation; Enteric Nervous System; Gastrointestinal Motility; Humans; Naltrexone; Narcotic Antagonists; Piperidines; Quaternary Ammonium Compounds; Receptors, Opioid | 2004 |
Peripherally acting mu-opioid-receptor antagonists and the connection between postoperative ileus and pain management: The anesthesiologist's view and beyond.
Topics: Analgesia; Analgesics, Opioid; Anesthesia; Anesthesiology; Anti-Inflammatory Agents, Non-Steroidal; Attitude of Health Personnel; Blood-Brain Barrier; Clinical Trials, Phase III as Topic; Humans; Ileus; Length of Stay; Naltrexone; Narcotic Antagonists; Nurse's Role; Outcome Assessment, Health Care; Pain, Postoperative; Patient Satisfaction; Piperidines; Postanesthesia Nursing; Postoperative Care; Postoperative Complications; Quaternary Ammonium Compounds; Receptors, Opioid, mu; Risk Factors | 2006 |
The surgical team and outcomes management: focus on postoperative ileus.
Topics: Analgesics, Opioid; Causality; Cost of Illness; Hospital Costs; Humans; Ileus; Incidence; Laparotomy; Length of Stay; Naltrexone; Narcotic Antagonists; Nurse's Role; Outcome Assessment, Health Care; Pain, Postoperative; Patient Care Team; Patient Satisfaction; Piperidines; Postanesthesia Nursing; Postoperative Care; Postoperative Complications; Professional Role; Quaternary Ammonium Compounds; Time Factors; Total Quality Management | 2006 |
Current choices--good or bad--for the proactive management of postoperative ileus: A surgeon's view.
Topics: Analgesia, Epidural; Analgesics, Opioid; Attitude of Health Personnel; Choice Behavior; Enteral Nutrition; Evidence-Based Medicine; General Surgery; Humans; Ileus; Intubation, Gastrointestinal; Laparoscopy; Laparotomy; Length of Stay; Naltrexone; Narcotic Antagonists; Outcome Assessment, Health Care; Patient Care Team; Patient Selection; Piperidines; Postoperative Care; Postoperative Complications; Practice Guidelines as Topic; Quaternary Ammonium Compounds; Risk Factors | 2006 |
Methylnaltrexone, a novel peripheral opioid receptor antagonist for the treatment of opioid side effects.
Topics: Analgesics, Opioid; Animals; Humans; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Receptors, Opioid | 2006 |
Methylnaltrexone: MNTX.
Topics: Clinical Trials as Topic; Colic; Constipation; Flatulence; Humans; Injections, Intravenous; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Treatment Outcome | 2006 |
Methylnaltrexone mechanisms of action and effects on opioid bowel dysfunction and other opioid adverse effects.
Topics: Analgesics, Opioid; Constipation; Humans; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds | 2007 |
A review of methylnaltrexone, a peripheral opioid receptor antagonist, and its role in opioid-induced constipation.
Topics: Analgesics, Opioid; Constipation; Humans; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds | 2007 |
Cancer-related constipation.
Topics: Alprostadil; Constipation; Fatty Acids; Gastrointestinal Agents; Humans; Indoles; Lubiprostone; Naltrexone; Narcotic Antagonists; Neoplasms; Piperidines; Quaternary Ammonium Compounds; Serotonin Receptor Agonists | 2007 |
Novel opioid antagonists for opioid-induced bowel dysfunction and postoperative ileus.
Topics: Analgesics, Opioid; Gastrointestinal Transit; Humans; Ileus; Intestinal Diseases; Naltrexone; Narcotic Antagonists; Piperidines; Postoperative Complications; Quaternary Ammonium Compounds | 2007 |
The involvement of the mu-opioid receptor in gastrointestinal pathophysiology: therapeutic opportunities for antagonism at this receptor.
Topics: Analgesics, Opioid; Animals; Clinical Trials as Topic; Drug Evaluation, Preclinical; Gastrointestinal Diseases; Gastrointestinal Tract; Humans; Naltrexone; Narcotic Antagonists; Piperidines; Quaternary Ammonium Compounds; Receptors, Opioid, mu | 2008 |
Methylnaltrexone, a new peripheral mu-receptor antagonist for the prevention and treatment of opioid-induced extracerebral side effects.
Topics: Analgesics, Opioid; Gastrointestinal Motility; Humans; Ileus; Naltrexone; Postoperative Complications; Postoperative Nausea and Vomiting; Quaternary Ammonium Compounds; Receptors, Opioid, mu; Urinary Retention | 2008 |
Mu-opioid antagonists for opioid-induced bowel dysfunction.
Topics: Constipation; Defecation; Gastrointestinal Agents; Humans; Intestinal Diseases; Nalbuphine; Naloxone; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Piperidines; Quaternary Ammonium Compounds; Receptors, Opioid, mu | 2008 |
[News from the cochrane library: mu opioid antagonists for opioid-induced bowel dysfunction].
Topics: Analgesics, Opioid; Clinical Trials as Topic; Constipation; Gastrointestinal Transit; Humans; Nalbuphine; Naloxone; Naltrexone; Narcotic Antagonists; Piperidines; Quaternary Ammonium Compounds; Receptors, Opioid, mu | 2008 |
Novel opioid antagonists for opioid-induced bowel dysfunction and postoperative ileus.
Topics: Analgesics, Opioid; Blood-Brain Barrier; Drug Approval; Europe; Humans; Ileus; Myocardial Infarction; Naltrexone; Narcotic Antagonists; Patient Selection; Piperidines; Postoperative Complications; Quaternary Ammonium Compounds; Research Design; Safety; United States; United States Food and Drug Administration | 2009 |
Use of FDA approved methamphetamine to allow adjunctive use of methylnaltrexone to mediate core anti-growth factor signaling effects in glioblastoma.
Topics: Brain Neoplasms; Central Nervous System Stimulants; Drug Approval; Drug Synergism; Glioblastoma; Humans; Methamphetamine; Naltrexone; Narcotic Antagonists; Neovascularization, Pathologic; Quaternary Ammonium Compounds; United States; United States Food and Drug Administration; Vascular Endothelial Growth Factor A | 2009 |
Opioid receptors in the gastrointestinal tract.
Topics: Animals; Constipation; Gastrointestinal Tract; Humans; Naloxone; Naltrexone; Narcotic Antagonists; Piperidines; Quaternary Ammonium Compounds; Receptors, Opioid | 2009 |
Methylnaltrexone: the answer to opioid-induced constipation?
Topics: Analgesics, Opioid; Animals; Constipation; Gastrointestinal Transit; Humans; Naltrexone; Quaternary Ammonium Compounds | 2009 |
Pharmacological management of postoperative ileus.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anti-Inflammatory Agents, Non-Steroidal; Bisacodyl; Cathartics; Cisapride; Dihydroergotamine; Humans; Ileus; Inflammation; Naltrexone; Neostigmine; Parasympathomimetics; Piperidines; Postoperative Complications; Propranolol; Quaternary Ammonium Compounds; Receptors, Opioid, mu; Serotonin Receptor Agonists | 2009 |
Methylnaltrexone methobromide: the first peripherally active, centrally inactive opioid receptor-antagonist.
Topics: Animals; Clinical Trials as Topic; Drug Interactions; Humans; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds | 2009 |
Methylnaltrexone.
Topics: Humans; Laxatives; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds | 2009 |
[Methylnaltrexone. A new approach for therapy of opioid-induced obstipation].
Topics: Analgesics, Opioid; Clinical Trials as Topic; Constipation; Critical Care; Humans; Naltrexone; Narcotic Antagonists; Palliative Care; Quaternary Ammonium Compounds | 2009 |
Methylnaltrexone: a novel approach for the management of opioid-induced constipation in patients with advanced illness.
Topics: Analgesics, Opioid; Clinical Trials as Topic; Constipation; Defecation; Drug Approval; Gastrointestinal Motility; Humans; Injections, Intravenous; Injections, Subcutaneous; Laxatives; Naltrexone; Narcotic Antagonists; Palliative Care; Quaternary Ammonium Compounds; Treatment Outcome | 2009 |
Methylnaltrexone bromide: new drug for the treatment of opioid-induced bowel dysfunction.
Topics: Analgesics, Opioid; Clinical Trials as Topic; Constipation; Dose-Response Relationship, Drug; Drug Interactions; Gastrointestinal Transit; Half-Life; Humans; Infusions, Intravenous; Infusions, Subcutaneous; Laxatives; Naltrexone; Narcotic Antagonists; Postoperative Complications; Quaternary Ammonium Compounds | 2009 |
Methylnaltrexone.
Topics: Analgesics, Opioid; Constipation; Humans; Molecular Structure; Naltrexone; Quaternary Ammonium Compounds; Randomized Controlled Trials as Topic; Receptors, Opioid, mu; Treatment Outcome | 2010 |
The role of opioid receptor antagonists in the treatment of opioid-induced constipation: a review.
Topics: Analgesics, Opioid; Clinical Trials as Topic; Constipation; Delayed-Action Preparations; Drug Combinations; Humans; Laxatives; Naloxone; Naltrexone; Narcotic Antagonists; Oxycodone; Quaternary Ammonium Compounds | 2010 |
Methylnaltrexone: treatment for opioid-induced constipation.
Topics: Analgesics, Opioid; Constipation; Defecation; Humans; Naltrexone; Narcotic Antagonists; Pain, Intractable; Palliative Care; Quality of Life; Quaternary Ammonium Compounds | 2011 |
Methylnaltrexone bromide: research update of pharmacokinetics following parenteral administration.
Topics: Clinical Trials as Topic; Constipation; Humans; Injections, Intravenous; Injections, Subcutaneous; Naltrexone; Narcotic Antagonists; Palliative Care; Quaternary Ammonium Compounds | 2011 |
Laxatives or methylnaltrexone for the management of constipation in palliative care patients.
Topics: Analgesics, Opioid; Anthraquinones; Cathartics; Constipation; Humans; Lactulose; Magnesium Hydroxide; Naltrexone; Palliative Care; Paraffin; Quaternary Ammonium Compounds; Randomized Controlled Trials as Topic; Senna Extract | 2011 |
Use of pure opioid antagonists for management of opioid-induced pruritus.
Topics: Adult; Analgesics, Opioid; Child; Humans; Infusions, Intravenous; Naloxone; Naltrexone; Narcotic Antagonists; Pruritus; Quality of Life; Quaternary Ammonium Compounds | 2011 |
Alternatives to prokinetics to move the pylorus and colon.
Topics: Acupuncture Therapy; Animals; Colon; Complementary Therapies; Enema; Gastrointestinal Agents; Gastrointestinal Diseases; Gastrointestinal Motility; Humans; Laxatives; Naltrexone; Narcotic Antagonists; Piperidines; Probiotics; Pylorus; Quaternary Ammonium Compounds | 2012 |
Management of opioid-induced constipation in cancer patients: focus on methylnaltrexone.
Topics: Analgesics, Opioid; Constipation; Humans; Naltrexone; Narcotic Antagonists; Neoplasms; Pain; Palliative Care; Quaternary Ammonium Compounds | 2012 |
Motility disorders of the colon and rectum.
Topics: Constipation; Diet; Dipeptides; Diverticulosis, Colonic; Gastrointestinal Agents; Gastrointestinal Transit; Humans; Naltrexone; Narcotic Antagonists; Peptides; Piperidines; Quaternary Ammonium Compounds; Rectal Diseases; Thiazepines; Tryptophan Hydroxylase | 2013 |
Gastrointestinal dysmotility: evidence and clinical management.
Topics: Cholecystokinin; Critical Illness; Enteral Nutrition; Evidence-Based Medicine; Gastric Emptying; Gastrointestinal Agents; Gastrointestinal Diseases; Ghrelin; Humans; Intestine, Small; Motilin; Naltrexone; Quaternary Ammonium Compounds; Randomized Controlled Trials as Topic | 2013 |
Laxatives or methylnaltrexone for the management of constipation in palliative care patients.
Topics: Aged; Constipation; Evidence-Based Nursing; Humans; Laxatives; Middle Aged; Naltrexone; Palliative Care; Quaternary Ammonium Compounds; Randomized Controlled Trials as Topic | 2013 |
Pharmacological treatment of constipation in palliative care.
Topics: Analgesics, Opioid; Constipation; Humans; Injections, Subcutaneous; Laxatives; Naltrexone; Narcotic Antagonists; Palliative Care; Practice Guidelines as Topic; Quaternary Ammonium Compounds | 2013 |
Efficacy of pharmacological therapies for the treatment of opioid-induced constipation: systematic review and meta-analysis.
Topics: Alprostadil; Analgesics, Opioid; Benzofurans; Constipation; Female; Gastrointestinal Agents; Humans; Lubiprostone; Male; Naloxone; Naltrexone; Narcotic Antagonists; Peptides; Piperidines; Quaternary Ammonium Compounds; Receptors, Opioid, mu | 2013 |
Overview and treatment of opioid-induced constipation.
Topics: Analgesics, Opioid; Combined Modality Therapy; Constipation; Delayed-Action Preparations; Diet Therapy; Humans; Laxatives; Life Style; Naloxone; Naltrexone; Narcotic Antagonists; Piperidines; Quaternary Ammonium Compounds | 2013 |
[Constipation management in palliative care].
Topics: Administration, Oral; Aged; Constipation; Dose-Response Relationship, Drug; Female; Humans; Injections, Subcutaneous; Laxatives; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Palliative Care; Quaternary Ammonium Compounds; Randomized Controlled Trials as Topic | 2013 |
Treatment of opioid-induced constipation: focus on the peripheral μ-opioid receptor antagonist methylnaltrexone.
Topics: Analgesics, Opioid; Clinical Trials as Topic; Constipation; Dietary Fiber; Humans; Laxatives; Naltrexone; Narcotic Antagonists; Pain; Quaternary Ammonium Compounds; Receptors, Opioid, mu | 2013 |
[Opiate induced constipation--mechanisms, relevance and treatment].
Topics: Administration, Cutaneous; Administration, Oral; Analgesics, Opioid; Constipation; Drug Therapy, Combination; Gastrointestinal Motility; Humans; Laxatives; Naltrexone; Narcotic Antagonists; Oxycodone; Quaternary Ammonium Compounds | 2013 |
Opioid antagonists.
Topics: Hospice Care; Humans; Internet; Naloxone; Naltrexone; Narcotic Antagonists; Palliative Care; Quaternary Ammonium Compounds | 2014 |
Laxatives for the management of constipation in people receiving palliative care.
Topics: Analgesics, Opioid; Anthraquinones; Cathartics; Constipation; Humans; Lactulose; Magnesium Hydroxide; Naltrexone; Palliative Care; Paraffin; Quaternary Ammonium Compounds; Randomized Controlled Trials as Topic; Senna Extract | 2015 |
The mu opioid receptor: A new target for cancer therapy?
Topics: Animals; Humans; Mice; Molecular Targeted Therapy; Naltrexone; Narcotic Antagonists; Neoplasms; Quaternary Ammonium Compounds; Receptors, Opioid, mu | 2015 |
Naloxegol: A Novel Therapy in the Management of Opioid-Induced Constipation.
Topics: Analgesics, Opioid; Constipation; Drug Interactions; Humans; Morphinans; Naltrexone; Narcotic Antagonists; Pain; Polyethylene Glycols; Quality of Life; Quaternary Ammonium Compounds; Randomized Controlled Trials as Topic | 2016 |
Constipation: opioid antagonists in people prescribed opioids.
Topics: Analgesics, Opioid; Constipation; Gastrointestinal Agents; Humans; Naloxone; Naltrexone; Narcotic Antagonists; Piperidines; Quaternary Ammonium Compounds; Treatment Outcome | 2015 |
Opioid-induced constipation in chronic noncancer pain.
Topics: Analgesics, Opioid; Chloride Channel Agonists; Chronic Pain; Constipation; Humans; Lubiprostone; Morphinans; Naltrexone; Narcotic Antagonists; Polyethylene Glycols; Quaternary Ammonium Compounds; Receptors, Opioid, mu | 2016 |
Efficacy of methylnaltrexone for the treatment of opiod-induced constipation: a meta-analysis and systematic review.
Topics: Analgesics, Opioid; Chronic Pain; Constipation; Humans; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Receptors, Opioid, mu; Treatment Outcome | 2016 |
Constipation in Elderly Patients with Noncancer Pain: Focus on Opioid-Induced Constipation.
Topics: Aged; Analgesics, Opioid; Constipation; Health Personnel; Humans; Laxatives; Naltrexone; Narcotic Antagonists; Pain; Quaternary Ammonium Compounds; Receptors, Opioid, mu; Treatment Outcome | 2016 |
[Management of adverse effects of opioid therapy].
Topics: Administration, Cutaneous; Administration, Oral; Analgesics, Opioid; Chronic Pain; Constipation; Drug-Related Side Effects and Adverse Reactions; Germany; Humans; Morphinans; Naltrexone; Narcotic Antagonists; Polyethylene Glycols; Quaternary Ammonium Compounds; Treatment Outcome | 2017 |
Evidence Based Review of Pharmacotherapy for Opioid-Induced Constipation in Noncancer Pain.
Topics: Analgesics, Opioid; Chronic Pain; Constipation; Evidence-Based Practice; Humans; Laxatives; Lubiprostone; Morphinans; Naltrexone; Narcotic Antagonists; Piperidines; Polyethylene Glycols; Quaternary Ammonium Compounds; Randomized Controlled Trials as Topic | 2018 |
Management of Opioid-Induced Constipation in Patients with Malignancy.
Topics: Analgesics, Opioid; Cancer Pain; Constipation; Enema; Gastrointestinal Agents; Gastrostomy; Humans; Laxatives; Morphinans; Naltrexone; Piperidines; Polyethylene Glycols; Practice Guidelines as Topic; Quaternary Ammonium Compounds | 2018 |
Mu-opioid antagonists for opioid-induced bowel dysfunction in people with cancer and people receiving palliative care.
Topics: Constipation; Defecation; Female; Gastrointestinal Agents; Humans; Intestinal Diseases; Male; Nalbuphine; Naloxone; Naltrexone; Narcotic Antagonists; Neoplasms; Opioid-Related Disorders; Oxycodone; Palliative Care; Piperidines; Quaternary Ammonium Compounds; Randomized Controlled Trials as Topic; Receptors, Opioid, mu | 2018 |
Methylnaltrexone bromide for the treatment of opioid-induced constipation.
Topics: Analgesics, Opioid; Chronic Pain; Clinical Trials as Topic; Constipation; Government Regulation; Half-Life; Humans; Naltrexone; Quality of Life; Quaternary Ammonium Compounds; Treatment Outcome | 2018 |
Opioid receptors in the GI tract: targets for treatment of both diarrhea and constipation in functional bowel disorders?
Topics: Analgesics, Opioid; Animals; Antidiarrheals; Constipation; Defecation; Diarrhea; Gastrointestinal Motility; Gastrointestinal Tract; Humans; Imidazoles; Inflammatory Bowel Diseases; Laxatives; Morphinans; Naltrexone; Narcotic Antagonists; Phenylalanine; Polyethylene Glycols; Quaternary Ammonium Compounds; Receptors, Opioid, mu; Signal Transduction | 2018 |
First-Dose Efficacy of Methylnaltrexone in Patients with Severe Medical Illness and Opioid-Induced Constipation: A Pooled Analysis.
Topics: Aged; Analgesics, Opioid; Constipation; Humans; Male; Naltrexone; Opioid-Induced Constipation; Quaternary Ammonium Compounds | 2022 |
Antagonists of the Mu-Opioid Receptor in the Cancer Patient: Fact or Fiction?
Topics: Cell Proliferation; Humans; Naltrexone; Narcotic Antagonists; Neoplasms; Quaternary Ammonium Compounds; Receptors, Opioid | 2022 |
Reductions in All-Cause Mortality Associated with the Use of Methylnaltrexone for Opioid-Induced Bowel Disorders: A Pooled Analysis.
Topics: Analgesics, Opioid; Chronic Pain; Constipation; Double-Blind Method; Humans; Naltrexone; Narcotic Antagonists; Randomized Controlled Trials as Topic; Retrospective Studies | 2023 |
Mu-opioid antagonists for opioid-induced bowel dysfunction in people with cancer and people receiving palliative care.
Topics: Adult; Analgesics, Opioid; Child; Humans; Naloxone; Naltrexone; Narcotic Antagonists; Neoplasms; Opioid-Induced Constipation; Oxycodone; Palliative Care; Quaternary Ammonium Compounds; Substance Withdrawal Syndrome | 2022 |
54 trial(s) available for naltrexone and methylnaltrexone
| Article | Year |
|---|---|
Efficacy of methylnaltrexone versus naloxone for reversal of morphine-induced depression of hypoxic ventilatory response.
Topics: Adult; Double-Blind Method; Humans; Hypoxia; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Respiration | 1994 |
Methylnaltrexone prevents morphine-induced delay in oral-cecal transit time without affecting analgesia: a double-blind randomized placebo-controlled trial.
Topics: Adolescent; Adult; Analgesics, Opioid; Breath Tests; Cold Temperature; Double-Blind Method; Female; Gastrointestinal Transit; Humans; Hydrogen; Injections, Intravenous; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain Measurement; Pressure; Quaternary Ammonium Compounds | 1996 |
Evaluation of methylnaltrexone for the reduction of postoperative vomiting and nausea incidences.
Topics: Adult; Antiemetics; Double-Blind Method; Female; Humans; Middle Aged; Naltrexone; Narcotic Antagonists; Nausea; Postoperative Complications; Prospective Studies; Quaternary Ammonium Compounds; Vomiting | 1995 |
Safety and tolerance of methylnaltrexone in healthy humans: a randomized, placebo-controlled, intravenous, ascending-dose, pharmacokinetic study.
Topics: Adult; Drug Tolerance; Humans; Injections, Intravenous; Male; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds | 1997 |
The safety and efficacy of oral methylnaltrexone in preventing morphine-induced delay in oral-cecal transit time.
Topics: Administration, Oral; Adult; Analgesics, Opioid; Breath Tests; Dose-Response Relationship, Drug; Female; Gastrointestinal Transit; Humans; Hydrogen; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Quaternary Ammonium Compounds; Reference Values; Single-Blind Method | 1997 |
Opioid-induced delay in gastric emptying: a peripheral mechanism in humans.
Topics: Acetaminophen; Adult; Cross-Over Studies; Double-Blind Method; Female; Gastric Emptying; Humans; Male; Naltrexone; Narcotic Antagonists; Narcotics; Quaternary Ammonium Compounds | 1997 |
Efficacy of orally administered methylnaltrexone in decreasing subjective effects after intravenous morphine.
Topics: Administration, Oral; Adult; Affect; Arousal; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Infusions, Intravenous; Male; Morphine; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Treatment Outcome | 1998 |
Methylnaltrexone for reversal of constipation due to chronic methadone use: a randomized controlled trial.
Topics: Adult; Analgesics, Opioid; Constipation; Double-Blind Method; Female; Gastrointestinal Transit; Humans; Male; Methadone; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Statistics, Nonparametric; Substance Withdrawal Syndrome | 2000 |
Effects of enteric-coated methylnaltrexone in preventing opioid-induced delay in oral-cecal transit time.
Topics: Administration, Oral; Adult; Breath Tests; Double-Blind Method; Female; Gastrointestinal Agents; Gastrointestinal Transit; Humans; Lactulose; Male; Morphine; Naltrexone; Narcotic Antagonists; Pilot Projects; Quaternary Ammonium Compounds; Tablets, Enteric-Coated; Time Factors | 2000 |
Oral methylnaltrexone for opioid-induced constipation.
Topics: Administration, Oral; Adult; Analgesics, Opioid; Constipation; Humans; Methadone; Naltrexone; Narcotic Antagonists; Narcotics; Quaternary Ammonium Compounds; Single-Blind Method | 2000 |
Effects of subcutaneous methylnaltrexone on morphine-induced peripherally mediated side effects: a double-blind randomized placebo-controlled trial.
Topics: Administration, Oral; Adult; Analgesics, Opioid; Breath Tests; Double-Blind Method; Female; Gastrointestinal Transit; Humans; Injections, Intravenous; Injections, Subcutaneous; Male; Morphine; Naltrexone; Narcotic Antagonists; Peripheral Nervous System; Quaternary Ammonium Compounds | 2002 |
Tolerability, gut effects, and pharmacokinetics of methylnaltrexone following repeated intravenous administration in humans.
Topics: Adult; Area Under Curve; Female; Gastrointestinal Transit; Half-Life; Humans; Injections, Intravenous; Male; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds | 2005 |
Pharmacokinetics of the opioid antagonist N-methylnaltrexone and evaluation of its effects on gastrointestinal tract function in horses treated or not treated with morphine.
Topics: Analgesics, Opioid; Animals; Drug Interactions; Gastrointestinal Tract; Gastrointestinal Transit; Horses; Male; Morphine; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds | 2006 |
Reversal of opioid-induced bladder dysfunction by intravenous naloxone and methylnaltrexone.
Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Double-Blind Method; Humans; Infusions, Intravenous; Male; Middle Aged; Miosis; Muscle Contraction; Naloxone; Naltrexone; Narcotic Antagonists; Piperidines; Quaternary Ammonium Compounds; Remifentanil; Treatment Outcome; Urinary Bladder; Urinary Retention; Urination | 2007 |
Subcutaneous methylnaltrexone for the treatment of opioid-induced constipation in patients with advanced illness: a double-blind, randomized, parallel group, dose-ranging study.
Topics: Acquired Immunodeficiency Syndrome; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Diarrhea; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Injections, Subcutaneous; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Neoplasms; Pain; Pain Measurement; Quaternary Ammonium Compounds; Terminal Care | 2008 |
Methylnaltrexone for opioid-induced constipation in advanced illness.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Constipation; Defecation; Double-Blind Method; Female; Humans; Injections, Subcutaneous; Laxatives; Logistic Models; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Terminally Ill | 2008 |
Methylnaltrexone treatment of opioid-induced constipation in patients with advanced illness.
Topics: Analgesics, Opioid; Constipation; Defecation; Double-Blind Method; Humans; Laxatives; Naltrexone; Narcotic Antagonists; Pain, Intractable; Palliative Care; Quaternary Ammonium Compounds | 2009 |
Metabolism of intravenous methylnaltrexone in mice, rats, dogs, and humans.
Topics: Adult; Animals; Biotransformation; Chromatography, High Pressure Liquid; Dealkylation; Dogs; Glucuronidase; Humans; Injections, Intravenous; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Mice; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley; Species Specificity | 2010 |
The effects of methylnaltrexone alone and in combination with acutely administered codeine on gastrointestinal and colonic transit in health.
Topics: Adolescent; Adult; Analgesics, Opioid; Codeine; Double-Blind Method; Drug Combinations; Female; Gastrointestinal Tract; Gastrointestinal Transit; Humans; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Receptors, Opioid, mu; Young Adult | 2010 |
Effect of subcutaneous methylnaltrexone on patient-reported constipation symptoms.
Topics: Analgesics, Opioid; Back Pain; Chronic Disease; Constipation; Double-Blind Method; Female; Humans; Injections, Subcutaneous; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds | 2011 |
Subcutaneous methylnaltrexone for treatment of opioid-induced constipation in patients with chronic, nonmalignant pain: a randomized controlled study.
Topics: Adult; Aged; Analgesics, Opioid; Chi-Square Distribution; Constipation; Defecation; Double-Blind Method; Female; Humans; Intention to Treat Analysis; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Pain; Quaternary Ammonium Compounds; Surveys and Questionnaires; Treatment Outcome | 2011 |
Safety and efficacy of methylnaltrexone in shortening the duration of postoperative ileus following segmental colectomy: results of two randomized, placebo-controlled phase 3 trials.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Colectomy; Dose-Response Relationship, Drug; Double-Blind Method; Female; Follow-Up Studies; Humans; Ileus; Injections, Intravenous; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Postoperative Complications; Quaternary Ammonium Compounds; Retrospective Studies; Treatment Outcome; Young Adult | 2011 |
Methylnaltrexone for opioid-induced constipation in patients with advanced illness: a 3-month open-label treatment extension study.
Topics: Aged; Aged, 80 and over; Analgesics, Opioid; Constipation; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Injections, Subcutaneous; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Substance Withdrawal Syndrome; Time Factors; Treatment Outcome | 2011 |
Efficacy of subcutaneous methylnaltrexone in the treatment of opioid-induced constipation: a responder post hoc analysis.
Topics: Adult; Analgesics, Opioid; Constipation; Double-Blind Method; Female; Humans; Injections, Subcutaneous; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Placebos; Quaternary Ammonium Compounds; Treatment Outcome | 2011 |
Subcutaneous methylnaltrexone for treatment of acute opioid-induced constipation: phase 2 study in rehabilitation after orthopedic surgery.
Topics: Aged; Analgesics, Opioid; Constipation; Double-Blind Method; Female; Humans; Injections, Subcutaneous; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Orthopedic Procedures; Pilot Projects; Quaternary Ammonium Compounds; Rehabilitation; Treatment Outcome | 2012 |
Characterization of abdominal pain during methylnaltrexone treatment of opioid-induced constipation in advanced illness: a post hoc analysis of two clinical trials.
Topics: Abdominal Pain; Adult; Aged; Analgesics, Opioid; Colic; Constipation; Double-Blind Method; Female; Humans; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Pain Measurement; Quaternary Ammonium Compounds | 2011 |
Effects of remifentanil on the esophagogastric junction and swallowing.
Topics: Adult; Anesthetics, Intravenous; Cross-Over Studies; Data Interpretation, Statistical; Deglutition; Double-Blind Method; Esophagogastric Junction; Female; Humans; Male; Manometry; Naltrexone; Narcotic Antagonists; Piperidines; Quaternary Ammonium Compounds; Receptors, Opioid, mu; Remifentanil; Stomach; Young Adult | 2013 |
Methylnaltrexone for opioid-induced constipation in pediatric oncology patients.
Topics: Adolescent; Analgesics, Opioid; Child; Child, Preschool; Constipation; Female; Humans; Male; Naltrexone; Narcotic Antagonists; Neoplasms; Pain; Quaternary Ammonium Compounds; Retrospective Studies | 2013 |
The effect of methylnaltrexone on the side effects of intrathecal morphine after orthopedic surgery under spinal anesthesia.
Topics: Adult; Analgesics, Opioid; Anesthesia, Spinal; Double-Blind Method; Female; Humans; Male; Middle Aged; Morphine; Naltrexone; Narcotic Antagonists; Orthopedic Procedures; Pain, Postoperative; Postoperative Complications; Quaternary Ammonium Compounds; Young Adult | 2015 |
Efficacy and Tolerability of Subcutaneous Methylnaltrexone in Patients with Advanced Illness and Opioid-Induced Constipation: A Responder Analysis of 2 Randomized, Placebo-Controlled Trials.
Topics: Adult; Aged; Analgesics, Opioid; Constipation; Double-Blind Method; Female; Humans; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Treatment Outcome | 2015 |
Methylnaltrexone: its pharmacological effects alone and effects on morphine in healthy volunteers.
Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Double-Blind Method; Female; Healthy Volunteers; Heart Rate; Humans; Infusions, Intravenous; Male; Morphine; Naltrexone; Narcotic Antagonists; Pupil; Quaternary Ammonium Compounds; Receptors, Opioid, mu; Treatment Outcome; Young Adult | 2015 |
Peripheral opioid receptor blockade increases postoperative morphine demands--a randomized, double-blind, placebo-controlled trial.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesia, Patient-Controlled; Analgesics, Opioid; Arthroplasty, Replacement, Knee; Double-Blind Method; Female; Humans; Male; Middle Aged; Morphine; Naltrexone; Narcotic Antagonists; Pain Measurement; Pain, Postoperative; Quaternary Ammonium Compounds; Young Adult | 2014 |
Methylnaltrexone to prevent intrathecal morphine-induced pruritus after Caesarean delivery: a multicentre, randomized clinical trial.
Topics: Adult; Analgesia, Obstetrical; Analgesics, Opioid; Anesthesia, Spinal; Australia; Cesarean Section; Female; Humans; Middle Aged; Morphine; Naltrexone; Narcotic Antagonists; Postoperative Complications; Pregnancy; Pruritus; Quaternary Ammonium Compounds; Singapore; Treatment Outcome; United States; Young Adult | 2015 |
The effects of morphine and methylnaltrexone on gastrointestinal pain in healthy male participants.
Topics: Administration, Rectal; Adult; Analgesics, Opioid; Cross-Over Studies; Double-Blind Method; Healthy Volunteers; Humans; Injections, Subcutaneous; Male; Middle Aged; Morphine; Muscle, Skeletal; Naltrexone; Narcotic Antagonists; Pupil; Quaternary Ammonium Compounds; Rectum; Skin; Visceral Pain; Young Adult | 2015 |
Fixed-Dose Subcutaneous Methylnaltrexone in Patients with Advanced Illness and Opioid-Induced Constipation: Results of a Randomized, Placebo-Controlled Study and Open-Label Extension.
Topics: Aged; Analgesics, Opioid; Constipation; Double-Blind Method; Female; Humans; Injections, Subcutaneous; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Patient Safety; Placebos; Quaternary Ammonium Compounds; Severity of Illness Index | 2015 |
Extended-release but not immediate-release and subcutaneous methylnaltrexone antagonizes the loperamide-induced delay of whole-gut transit time in healthy subjects.
Topics: Adult; Antidiarrheals; Constipation; Delayed-Action Preparations; Dose-Response Relationship, Drug; Drug Antagonism; Female; Gastrointestinal Motility; Gastrointestinal Transit; Humans; Injections, Subcutaneous; Loperamide; Male; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Young Adult | 2016 |
Protocol for a randomised control trial of methylnaltrexone for the treatment of opioid-induced constipation and gastrointestinal stasis in intensive care patients (MOTION).
Topics: Adult; Analgesics, Opioid; Blood-Brain Barrier; Constipation; Critical Care; Female; Gastrointestinal Motility; Humans; Laxatives; Male; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds | 2016 |
Treatment with methylnaltrexone is associated with increased survival in patients with advanced cancer.
Topics: Adult; Aged; Analgesics, Opioid; Constipation; Disease-Free Survival; Female; Humans; Kaplan-Meier Estimate; Laxatives; Male; Middle Aged; Naltrexone; Neoplasms; Quaternary Ammonium Compounds; Receptors, Opioid, mu | 2016 |
Phase II trial of subcutaneous methylnaltrexone in the treatment of severe opioid-induced constipation (OIC) in cancer patients: an exploratory study.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Constipation; Female; Humans; Injections, Subcutaneous; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Neoplasm Staging; Neoplasms; Prognosis; Quaternary Ammonium Compounds | 2017 |
Randomized, Double-Blind Trial of Oral Methylnaltrexone for the Treatment of Opioid-Induced Constipation in Patients with Chronic Noncancer Pain.
Topics: Administration, Oral; Adult; Aged; Analgesics, Opioid; Chronic Pain; Constipation; Double-Blind Method; Female; Humans; Injections, Subcutaneous; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Receptors, Opioid, mu; Treatment Outcome | 2017 |
Effect of methylnaltrexone and naloxone on esophageal motor function in man.
Topics: Adolescent; Adult; Cross-Over Studies; Esophageal pH Monitoring; Esophageal Sphincter, Lower; Female; Humans; Male; Naloxone; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Receptors, Opioid, mu; Single-Blind Method; Young Adult | 2017 |
Effects of Buprenorphine, Methylnaltrexone, and Their Combination on Gastrointestinal Transit in Healthy New Zealand White Rabbits.
Topics: Analgesics, Opioid; Animals; Body Weight; Buprenorphine; Drug Therapy, Combination; Feces; Gastrointestinal Transit; Laboratory Animal Science; Male; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Rabbits | 2017 |
Long-Term Safety and Efficacy of Subcutaneous Methylnaltrexone in Patients with Opioid-Induced Constipation and Chronic Noncancer Pain: A Phase 3, Open-Label Trial.
Topics: Adult; Aged; Analgesics, Opioid; Chronic Pain; Constipation; Female; Humans; Injections, Subcutaneous; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Time | 2017 |
Identifying and Treating Opioid Side Effects: The Development of Methylnaltrexone.
Topics: Adult; Analgesics, Opioid; Constipation; Double-Blind Method; Female; Humans; Male; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Treatment Outcome | 2019 |
Effects of Methylnaltrexone on Ticagrelor-Induced Antiplatelet Effects in Coronary Artery Disease Patients Treated With Morphine.
Topics: Administration, Intravenous; Administration, Oral; Aged; Analgesics, Opioid; Blood Platelets; Cell Adhesion Molecules; Coronary Artery Disease; Cross-Over Studies; Double-Blind Method; Drug Interactions; Female; Florida; Gastric Emptying; Gastrointestinal Absorption; Humans; Male; Microfilament Proteins; Middle Aged; Morphine; Naltrexone; Narcotic Antagonists; Phosphoproteins; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Quaternary Ammonium Compounds; Ticagrelor; Treatment Outcome | 2019 |
Subcutaneous methylnaltrexone for opioid-induced constipation in advanced-illness patients with or without active cancer.
Topics: Adult; Aged; Cancer Pain; Double-Blind Method; Female; Humans; Injections, Subcutaneous; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Narcotics; Opioid-Induced Constipation; Outcome Assessment, Health Care; Quaternary Ammonium Compounds | 2020 |
Methylnaltrexone for the treatment of opioid-induced constipation and gastrointestinal stasis in intensive care patients. Results from the MOTION trial.
Topics: Adult; Analgesics, Opioid; Constipation; Critical Care; Humans; Naltrexone; Opioid-Induced Constipation; Quaternary Ammonium Compounds | 2020 |
The influence of brain metastases on the central nervous system effects of methylnaltrexone: a post hoc analysis of 3 randomized, double-blind studies.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Brain Neoplasms; Central Nervous System; Constipation; Double-Blind Method; Female; Humans; Male; Middle Aged; Naltrexone; Quaternary Ammonium Compounds | 2021 |
The Influence of Age on Central Effects of Methylnaltrexone in Patients with Opioid-Induced Constipation.
Topics: Age Factors; Aged; Analgesics, Opioid; Constipation; Humans; Naltrexone; Opioid-Induced Constipation; Quaternary Ammonium Compounds; Treatment Outcome | 2021 |
Effects of remifentanil on pharyngeal swallowing and esophageal motility: no impact of different bolus volumes and partial antagonism by methylnaltrexone.
Topics: Adult; Analgesics, Opioid; Deglutition; Drug Antagonism; Esophagus; Female; Healthy Volunteers; Humans; Injections, Intravenous; Male; Muscle Contraction; Muscle Relaxation; Naltrexone; Narcotic Antagonists; Pharynx; Quaternary Ammonium Compounds; Remifentanil | 2021 |
Perioperative subcutaneous methylnaltrexone does not enhance gastrointestinal recovery after posterior short-segment spinal arthrodesis surgery: a randomized controlled trial.
Topics: Analgesics, Opioid; Arthrodesis; Double-Blind Method; Humans; Naltrexone; Narcotic Antagonists; Pain, Postoperative; Quaternary Ammonium Compounds; Treatment Outcome | 2022 |
Attrition of methylnaltrexone treatment-emergent adverse events in patients with chronic noncancer pain and opioid-induced constipation: a post hoc pooled analysis of two clinical trials.
Topics: Adult; Analgesics, Opioid; Chronic Pain; Constipation; Double-Blind Method; Humans; Naltrexone; Opioid-Induced Constipation; Quaternary Ammonium Compounds; Treatment Outcome | 2021 |
Design and feasibility of a double-blind, randomized trial of peri-operative methylnaltrexone for postoperative ileus prevention after adult spinal arthrodesis.
Topics: Adult; Arthrodesis; Feasibility Studies; Humans; Ileus; Male; Naltrexone; Postoperative Complications; Quaternary Ammonium Compounds; Retrospective Studies | 2022 |
Effects of the peripherally acting μ-opioid receptor antagonist methylnaltrexone on acute pancreatitis severity: study protocol for a multicentre double-blind randomised placebo-controlled interventional trial, the PAMORA-AP trial.
Topics: Acute Disease; Humans; Multicenter Studies as Topic; Naltrexone; Narcotic Antagonists; Pancreatitis; Quaternary Ammonium Compounds; Randomized Controlled Trials as Topic; Research Design | 2021 |
170 other study(ies) available for naltrexone and methylnaltrexone
| Article | Year |
|---|---|
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Syntheses of novel high affinity ligands for opioid receptors.
Topics: Analgesics, Opioid; Crystallography, X-Ray; Furans; Humans; Ligands; Naltrexone; Narcotic Antagonists; Protein Binding; Receptors, Opioid | 2009 |
Design, synthesis, and biological evaluation of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4'-pyridyl)carboxamido]morphinan derivatives as peripheral selective μ opioid receptor Agents.
Topics: Analgesics; Animals; Caco-2 Cells; Drug Design; Gastrointestinal Motility; Humans; Male; Mice; Models, Molecular; Molecular Structure; Morphinans; Morphine Derivatives; Narcotic Antagonists; Radioligand Assay; Receptors, Opioid, mu; Structure-Activity Relationship; Tissue Distribution | 2012 |
Opioids as Substrates and Inhibitors of the Genetically Highly Variable Organic Cation Transporter OCT1.
Topics: Analgesics, Opioid; HEK293 Cells; Humans; Inhibitory Concentration 50; Models, Molecular; Organic Cation Transporter 1; Permeability; Protein Conformation | 2019 |
Reduction of learned helplessness by central administration of quaternary naltrexone.
Topics: Animals; Brain; Electroshock; Escape Reaction; Female; Helplessness, Learned; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Rats; Reaction Time; Receptors, Opioid | 1992 |
Modulation of immune status by a conditioned aversive stimulus: evidence for the involvement of endogenous opioids.
Topics: Animals; Avoidance Learning; Blood-Brain Barrier; Central Nervous System; Conditioning, Operant; Electroshock; Endorphins; Immune Tolerance; Killer Cells, Natural; Lymphocyte Activation; Male; Mitogens; Naltrexone; Narcotic Antagonists; Neuroimmunomodulation; Psychoneuroimmunology; Quaternary Ammonium Compounds; Rats; Rats, Inbred Lew; Receptors, Opioid; Stress, Physiological | 1992 |
Effects of the opiates on the paraventricular nucleus in genetically polydipsic mice.
Topics: Animals; Dynorphins; Female; In Vitro Techniques; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Microinjections; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Neurons; Paraventricular Hypothalamic Nucleus; Quaternary Ammonium Compounds; Synapses; Thirst | 1992 |
Role of central versus peripheral opioid receptors in analgesia induced by repeated administration of opioid antagonists.
Topics: Analgesia; Animals; Brain; Injections, Intraventricular; Injections, Subcutaneous; Male; Naltrexone; Narcotic Antagonists; Peripheral Nerves; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Opioid | 1991 |
EEG evidence that morphine and an enkephalin analog cross the blood-brain barrier.
Topics: Amino Acid Sequence; Animals; Blood-Brain Barrier; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Electroencephalography; Male; Molecular Sequence Data; Morphine; MSH Release-Inhibiting Hormone; Naltrexone; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains | 1991 |
Opiate antagonists inhibit feeding induced by 8-OH-DPAT: possible mediation in the nucleus accumbens.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Eating; Injections, Subcutaneous; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Quaternary Ammonium Compounds; Raphe Nuclei; Rats; Rats, Inbred Strains; Tetrahydronaphthalenes | 1991 |
5-Methylated naloxone, naltrexone, oxymorphone, and their 14-O-methyl ethers.
Topics: Animals; Ethers; In Vitro Techniques; Methylation; Naloxone; Naltrexone; Narcotic Antagonists; Oxymorphone; Quaternary Ammonium Compounds; Receptors, Opioid; Structure-Activity Relationship | 1990 |
Central but not peripheral opiate receptor blockade prolonged pituitary-adrenal responses to stress.
Topics: Adrenocorticotropic Hormone; Animals; Corticosterone; Hypothalamo-Hypophyseal System; Male; Naltrexone; Narcotic Antagonists; Pituitary-Adrenal System; Prolactin; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Stress, Physiological | 1990 |
Naltrexone blocks the expression of the conditioned elevation of natural killer cell activity in BALB/c mice.
Topics: Animals; Camphor; Conditioning, Classical; Female; Interferons; Killer Cells, Natural; Mice; Mice, Inbred BALB C; Naltrexone; Odorants; Poly I-C; Quaternary Ammonium Compounds | 1989 |
Effects of opiate antagonists and their quaternary analogues on nucleus accumbens self-stimulation.
Topics: Animals; Brain Mapping; Male; Motivation; Naloxone; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Oxymorphone; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Receptors, Opioid; Self Stimulation; Septal Nuclei | 1989 |
Suppression of juvenile social behavior requires antagonism of central opioid systems.
Topics: Animals; Behavior, Animal; Brain; Dose-Response Relationship, Drug; Endorphins; Female; Injections, Intraventricular; Male; Naltrexone; Play and Playthings; Quaternary Ammonium Compounds; Rats; Social Behavior | 1989 |
Variations in demethylation of N-methylnaltrexone in mice, rats, dogs, and humans.
Topics: Aged; Animals; Dogs; Feces; Female; Humans; Kinetics; Male; Mice; Middle Aged; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Rats; Species Specificity | 1989 |
Opioids in the systemic hemodynamic and renal responses to stress in spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Consciousness; Endorphins; Hemodynamics; Hypertension; Kidney; Male; Naloxone; Naltrexone; Narcotic Antagonists; Natriuresis; Quaternary Ammonium Compounds; Rats; Rats, Inbred SHR; Stress, Physiological | 1989 |
Taste aversion involving central opioid antagonism is potentiated in morphine-dependent rats.
Topics: Animals; Blood-Brain Barrier; Dose-Response Relationship, Drug; Drug Synergism; Infusions, Parenteral; Injections, Subcutaneous; Male; Morphine Dependence; Nalorphine; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Taste | 1989 |
The tegmental pedunculopontine nucleus: a brain-stem output of the limbic system critical for the conditioned place preferences produced by morphine and amphetamine.
Topics: Amphetamine; Animals; Brain Stem; Conditioning, Psychological; Dose-Response Relationship, Drug; Limbic System; Male; Morphine; Naltrexone; Narcotic Antagonists; Periaqueductal Gray; Pons; Psychotropic Drugs; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Retention, Psychology; Tegmentum Mesencephali | 1989 |
Central vs. peripheral mediation of opioid effects on alcohol consumption in free-feeding rats.
Topics: Alcohol Drinking; Animals; Dose-Response Relationship, Drug; Drinking Behavior; Drug Interactions; Loperamide; Male; Morphine; Naltrexone; Narcotic Antagonists; Piperidines; Polysorbates; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Time Factors | 1989 |
Quaternary naltrexone reveals the central mediation of conditional opioid analgesia.
Topics: Animals; Brain; Conditioning, Classical; Female; Injections, Intraventricular; Naltrexone; Pain; Quaternary Ammonium Compounds; Rats; Receptors, Opioid | 1987 |
The impairment of retention induced by pentylenetetrazol in mice may be mediated by a release of opioid peptides in the brain.
Topics: Animals; Avoidance Learning; Benzomorphans; beta-Endorphin; Brain; Dose-Response Relationship, Drug; Male; Memory; Mice; Mice, Inbred Strains; Naltrexone; Narcotic Antagonists; Pentylenetetrazole; Quaternary Ammonium Compounds; Receptors, Opioid; Retention, Psychology; Seizures | 1987 |
Peripheral receptors mediate the aversive conditioning effects of morphine in the rat.
Topics: Amphetamine; Animals; Capsaicin; Chlorides; Conditioning, Classical; Injections, Intraperitoneal; Lithium; Lithium Chloride; Male; Morphine; Naltrexone; Peritoneal Cavity; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Receptors, Opioid; Taste | 1987 |
Roles of central and peripheral mu, delta and kappa opioid receptors in the mediation of gastric acid secretory effects in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Brain; Cyclazocine; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; Gastric Acid; Male; Morphine; Naltrexone; Pyrrolidines; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1988 |
Central pharmacological activity of a quaternary ammonium compound in streptozotocin diabetic mice.
Topics: Animals; Blood-Brain Barrier; Cell Membrane Permeability; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Female; Injections, Subcutaneous; Insulin; Mice; Morphine; Naltrexone; Narcotic Antagonists; Pharmaceutical Vehicles; Quaternary Ammonium Compounds; Streptozocin | 1988 |
Intravenous kinetics and metabolism of [15,16-3H]naltrexonium methiodide in the rat.
Topics: Animals; Brain; Half-Life; Kinetics; Male; Naltrexone; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Stereoisomerism | 1987 |
Evidence for a peripheral action of thyrotropin releasing hormone on gastrointestinal transit in mice.
Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Drug Synergism; Gastrointestinal Transit; Loperamide; Male; Mice; Mice, Inbred Strains; Morphine; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Thiazolidines; Thyrotropin-Releasing Hormone | 1988 |
Pharmacological evidence of a central effect of naltrexone, morphine, and beta-endorphin and a peripheral effect of met- and leu-enkephalin on retention of an inhibitory response in mice.
Topics: Adrenal Medulla; Animals; Avoidance Learning; beta-Endorphin; Brain; Drug Interactions; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Male; Memory; Mice; Morphine; Naltrexone; Quaternary Ammonium Compounds; Retention, Psychology | 1985 |
Characterization of the discriminative stimulus effects of centrally administered morphine in the rat.
Topics: Animals; Discrimination Learning; Injections, Intraventricular; Injections, Subcutaneous; Male; Morphine; Naltrexone; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Receptors, Opioid | 1985 |
Central, stereoselective receptors mediate the acute effects of opiate antagonists on luteinizing hormone secretion.
Topics: Animals; Brain; Injections, Intraventricular; Luteinizing Hormone; Male; Naloxone; Naltrexone; Quaternary Ammonium Compounds; Rats; Receptors, Opioid; Stereoisomerism | 1986 |
Role of peripheral and central opioid activity in analgesia induced by restraint stress.
Topics: Analgesia; Animals; Brain Stem; Endorphins; Male; Naltrexone; Quaternary Ammonium Compounds; Rats; Receptors, Opioid; Restraint, Physical; Stress, Physiological; Tryptophan | 1987 |
An analysis of the paradoxical effect of morphine on runway speed and food consumption.
Topics: Animals; Avoidance Learning; Feeding Behavior; Food Deprivation; Male; Morphine; Motivation; Naltrexone; Nervous System; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Reward; Taste; Tegmentum Mesencephali | 1986 |
Antagonist treatment in nucleus accumbens or periaqueductal grey affects heroin self-administration.
Topics: Animals; Cocaine; Heroin; Male; Microinjections; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Periaqueductal Gray; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Self Administration | 1988 |
Morphine preexposure attenuates the aversive properties of opiates without preexposure to the aversive properties.
Topics: Animals; Conditioning, Psychological; Male; Morphine; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Reference Values; Saccharin; Taste | 1988 |
Evidence for the involvement of central opioidergic systems in L-tyrosine methyl ester-induced analgesia in the rat.
Topics: Analgesia; Animals; Endorphins; Injections, Intraventricular; Injections, Subcutaneous; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Tyrosine | 1988 |
Comparison of naltrexone and quaternary naltrexone after systemic and intracerebroventricular administration in pigeons.
Topics: Animals; Columbidae; Discrimination Learning; Injections, Intramuscular; Injections, Intraventricular; Morphine; Naltrexone; Quaternary Ammonium Compounds; Reinforcement Schedule | 1987 |
Enkephalin release into the ventral tegmental area in response to stress: modulation of mesocorticolimbic dopamine.
Topics: Animals; Dopamine; Electroshock; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Frontal Lobe; Male; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Septal Nuclei; Stress, Physiological; Tegmentum Mesencephali | 1987 |
Heroin self-administration: effects of antagonist treatment in lateral hypothalamus.
Topics: Animals; Catheterization; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Interactions; Heroin; Hypothalamus; Male; Microinjections; Naltrexone; Quaternary Ammonium Compounds; Rats; Self Administration | 1987 |
Is the motivational effect of opiate withdrawal reflected by common somatic indices of precipitated withdrawal? A place conditioning study in the rat.
Topics: Animals; Avoidance Learning; Behavior, Animal; Body Weight; Dose-Response Relationship, Drug; Drug Implants; Male; Morphine; Motivation; Naltrexone; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome | 1987 |
Effects of opiate antagonist treatment into either the periaqueductal grey or nucleus accumbens on heroin-induced locomotor activation.
Topics: Animals; Heroin; Injections; Male; Motor Activity; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Periaqueductal Gray; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Septal Nuclei | 1987 |
Evidence for a central but not adrenal, opioid mediation in hypertension induced by brief isolation in the rat.
Topics: Adrenalectomy; Animals; Blood Pressure; Corticosterone; Endorphins; Gastrointestinal Motility; Male; Morphine; Nalorphine; Naloxone; Naltrexone; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Social Isolation; Stress, Physiological | 1986 |
Central and peripheral contributions of endogenous opioid systems to nutrient selection in rats.
Topics: Animals; Central Nervous System; Dietary Carbohydrates; Dietary Fats; Dietary Proteins; Endorphins; Energy Intake; Feeding Behavior; Food Preferences; Male; Naltrexone; Peripheral Nerves; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains | 1985 |
Narcotic antagonist-induced hypotension in the spontaneously hypertensive rat.
Topics: Animals; Blood Pressure; Dose-Response Relationship, Drug; Heart Rate; Hypertension; Male; Naloxone; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Stereoisomerism | 1985 |
Quaternary naltrexone reverses morphine-induced behaviors.
Topics: Animals; Behavior, Animal; Locomotion; Male; Mice; Mice, Inbred C57BL; Morphine; Naltrexone; Quaternary Ammonium Compounds | 1985 |
Opioid involvement in hypertension induced by short-term isolation.
Topics: Adrenalectomy; Animals; Clonidine; Endorphins; Humans; Hypertension; Male; Naloxone; Naltrexone; Psychophysiologic Disorders; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Social Isolation | 1984 |
Endorphins in endotoxin-induced hyperglycemia in mice.
Topics: Animals; Endorphins; Endotoxins; Hyperglycemia; Male; Mice; Mice, Inbred C3H; Morphine; Naloxone; Naltrexone; Quaternary Ammonium Compounds | 1983 |
An antiabsorptive basis for precipitated withdrawal diarrhea in morphine-dependent rats.
Topics: Animals; Atropine; Biological Transport; Diarrhea; Gastrointestinal Motility; Hexamethonium Compounds; Humans; Intestinal Absorption; Male; Morphine; Morphine Dependence; Naltrexone; Quaternary Ammonium Compounds; Rats; Rats, Inbred Lew; Substance Withdrawal Syndrome; Water-Electrolyte Balance | 1984 |
Interaction of the opiate antagonist, naltrexone methyl bromide, with the acetylcholine receptor system of the motor end-plate.
Topics: Animals; Female; Membrane Potentials; Motor Endplate; Naloxone; Naltrexone; Neuromuscular Junction; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Receptors, Cholinergic | 1983 |
Reversal of morphine-induced catalepsy in the rat by narcotic antagonists and their quaternary derivatives.
Topics: Animals; Catalepsy; Humans; Injections, Intraventricular; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains | 1983 |
Effects of opiate antagonists and their quaternary derivatives on heroin self-administration in the rat.
Topics: Animals; Dose-Response Relationship, Drug; Heroin; Male; Naloxone; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Reinforcement, Psychology; Self Administration; Time Factors | 1984 |
Effects of naloxone and its quarternary analogue on stimulation-induced feeding.
Topics: Animals; Electric Stimulation; Feeding Behavior; Hypothalamus; Male; Naloxone; Naltrexone; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains | 1983 |
Opiate antagonists: central sites of action in suppressing water intake of the rat.
Topics: Animals; Dose-Response Relationship, Drug; Drinking Behavior; Male; Naloxone; Naltrexone; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains | 1981 |
GRF-induced feeding: evidence for protein selectivity and opiate involvement.
Topics: Analysis of Variance; Animals; Brain Mapping; Dietary Carbohydrates; Dietary Proteins; Feeding Behavior; Food Preferences; Growth Hormone-Releasing Hormone; Male; Microinjections; Naltrexone; Narcotic Antagonists; Paraventricular Hypothalamic Nucleus; Preoptic Area; Quaternary Ammonium Compounds; Rats; Rats, Wistar; Time Factors | 1994 |
Effects of methylnaltrexone on morphine-induced inhibition of contraction in isolated guinea-pig ileum and human intestine.
Topics: Adult; Aged; Animals; Gastrointestinal Motility; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Intestine, Small; Middle Aged; Morphine; Muscle Contraction; Naloxone; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds | 1995 |
Role of endogenous central opioid mechanisms in maintenance of body sodium balance.
Topics: Adaptation, Physiological; Animals; Injections, Intraventricular; Kidney; Male; Naltrexone; Narcotic Antagonists; Natriuresis; Opioid Peptides; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley; Sodium; Sodium, Dietary; Water-Electrolyte Balance | 1995 |
Effect of a peripheral and a central acting opioid antagonist on the testicular response to stress in rats.
Topics: Aldehyde-Lyases; Animals; Corticosterone; Cytochrome P-450 Enzyme System; Immobilization; Kinetics; Luteinizing Hormone; Male; Naloxone; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Rats; Rats, Wistar; Steroid 17-alpha-Hydroxylase; Stress, Psychological; Testis; Testosterone | 1994 |
Dose-related antagonism of the emetic effect of morphine by methylnaltrexone in dogs.
Topics: Animals; Dogs; Dose-Response Relationship, Drug; Injections, Intramuscular; Injections, Intravenous; Male; Morphine; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Vomiting | 1993 |
Effects of methylnaltrexone on morphine-induced cough suppression in guinea pigs.
Topics: Analgesia; Animals; Antitussive Agents; Guinea Pigs; Male; Morphine; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds | 1996 |
Systemic administration of dynorphin A-(1-13) markedly improves cycloheximide-induced amnesia in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amnesia; Analgesics; Animals; Avoidance Learning; Cycloheximide; Dynorphins; Injections, Intraventricular; Male; Memory; Mice; Naltrexone; Narcotic Antagonists; Protein Synthesis Inhibitors; Pyrrolidines; Quaternary Ammonium Compounds; Receptors, Opioid, kappa | 1996 |
Cancer pain remedy wins orphan drug status.
Topics: Blood-Brain Barrier; Constipation; Drug Therapy, Combination; Humans; Morphine; Naltrexone; Narcotic Antagonists; Nausea; Neoplasms; Orphan Drug Production; Pain; Quaternary Ammonium Compounds; United States; United States Food and Drug Administration | 1996 |
Methylnaltrexone: reversing the gastrointestinal effects of opioids.
Topics: Gastric Emptying; Humans; Naltrexone; Narcotic Antagonists; Narcotics; Quaternary Ammonium Compounds | 1997 |
The effect of opioid antagonists in local regulation of testicular response to acute stress in adult rats.
Topics: 3-Hydroxysteroid Dehydrogenases; Animals; Injections; Male; Naloxone; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Rats; Rats, Wistar; Restraint, Physical; Stress, Physiological; Testis; Testosterone | 1997 |
Methylnaltrexone attenuates taste aversion conditioned by low-dose ethanol.
Topics: Animals; Chromatography, Gas; Conditioning, Psychological; Ethanol; Kinetics; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley; Taste | 1998 |
The effect of acute stress and opioid antagonist on the activity of NADPH-P450 reductase in rat Leydig cells.
Topics: 17-alpha-Hydroxyprogesterone; Androstenedione; Animals; Cytochrome Reductases; Cytochrome-B(5) Reductase; Leydig Cells; Male; NADH, NADPH Oxidoreductases; NADPH-Ferrihemoprotein Reductase; Naltrexone; Narcotic Antagonists; Progesterone; Quaternary Ammonium Compounds; Rats; Rats, Wistar; Steroid 17-alpha-Hydroxylase; Steroids; Stress, Physiological; Testis; Testosterone | 1998 |
Role of central mu-opioid receptors in the modulation of nitric oxide production by splenocytes.
Topics: Analgesics; Analgesics, Opioid; Animals; Bacterial Toxins; Benzeneacetamides; Cell Division; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Enterotoxins; Enzyme Inhibitors; Injections, Intraventricular; Lymphocytes; Male; Naltrexone; Narcotic Antagonists; Neuroimmunomodulation; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Pyrrolidines; Quaternary Ammonium Compounds; Rats; Rats, Inbred Lew; Receptors, Opioid, mu; Spleen; Superantigens | 1998 |
Prevention of apomorphine- or cisplatin-induced emesis in the dog by a combination of methylnaltrexone and morphine.
Topics: Administration, Oral; Animals; Antiemetics; Antineoplastic Agents; Apomorphine; Cisplatin; Dogs; Drug Interactions; Drug Therapy, Combination; Emetics; Male; Morphine; Naltrexone; Narcotics; Quaternary Ammonium Compounds; Vomiting | 1998 |
Opioid antagonist modulation of ischaemia-induced ventricular arrhythmias: a peripheral mechanism.
Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Cardiovascular System; Coronary Disease; Drug Interactions; Heart Rate; Morphine; Myocardial Reperfusion Injury; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Rabbits | 1999 |
Endogenous opioids regulate the expression of inducible nitric oxide synthase by splenocytes.
Topics: Animals; Blotting, Western; Dose-Response Relationship, Drug; Ethylenediamines; Free Radical Scavengers; Lipopolysaccharides; Male; Naltrexone; Narcotic Antagonists; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Opioid Peptides; Quaternary Ammonium Compounds; Rats; Rats, Inbred Lew; Receptors, Opioid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spleen; Sulfanilamides | 1999 |
Gastric effects of methylnaltrexone on mu, kappa, and delta opioid agonists induced brainstem unitary responses.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Animals, Newborn; Brain Stem; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Morphine; Naltrexone; Narcotic Antagonists; Neurons; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Solitary Nucleus; Stomach; Vagus Nerve | 1999 |
Effects of intravenous methylnaltrexone on opioid-induced gut motility and transit time changes in subjects receiving chronic methadone therapy: a pilot study.
Topics: Adult; Analgesics, Opioid; Constipation; Female; Gastrointestinal Motility; Gastrointestinal Transit; Humans; Male; Methadone; Middle Aged; Naltrexone; Narcotic Antagonists; Pilot Projects; Quaternary Ammonium Compounds | 1999 |
Antagonism of heroin and morphine self-administration in rats by the morphine-6beta-glucuronide antagonist 3-O-methylnaltrexone.
Topics: Animals; Conditioning, Operant; Dose-Response Relationship, Drug; Heroin; Injections, Subcutaneous; Male; Morphine; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Narcotics; Pain Measurement; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley; Rats, Wistar; Self Administration | 1999 |
Acute exposure to saccharin reduces morphine analgesia in the the rat: evidence for involvement of N-methyl-D-aspartate and peripheral opioid receptors.
Topics: Analgesia; Analgesics, Opioid; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Quaternary Ammonium Compounds; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Saccharin; Sweetening Agents | 2000 |
Morphine tolerance in mice changes response of heroin from mu to delta opioid receptors.
Topics: Analgesics, Opioid; Animals; Drug Tolerance; Heroin; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Narcotics; Quaternary Ammonium Compounds; Receptors, Opioid, delta; Receptors, Opioid, mu | 2000 |
Managing constipation that's opioid-induced.
Topics: Administration, Oral; Adult; Analgesics, Opioid; Breast Neoplasms; Chemistry, Pharmaceutical; Constipation; Female; Humans; Methadone; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Quaternary Ammonium Compounds | 2000 |
Involvement of central mu- but not delta- or kappa-opioid receptors in immunomodulation.
Topics: Animals; Brain; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Immune System; Male; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Rats; Rats, Inbred Lew; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2000 |
Involvement of substance P and central opioid receptors in morphine modulation of the CHS response.
Topics: Androstanes; Animals; Benzimidazoles; Dermatitis, Contact; Dinitrofluorobenzene; Disease Models, Animal; Drug Administration Routes; Male; Morphine; Naltrexone; Narcotic Antagonists; Neurokinin-1 Receptor Antagonists; Quaternary Ammonium Compounds; Rats; Rats, Inbred Lew; Receptors, Opioid; Specific Pathogen-Free Organisms; Substance P | 2001 |
Pharmacokinetic profile of epidurally administered methylnaltrexone, a novel peripheral opioid antagonist in a rabbit model.
Topics: Animals; Injections, Epidural; Models, Animal; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Rabbits | 2001 |
Selective postoperative inhibition of gastrointestinal opioid receptors.
Topics: Humans; Intestinal Obstruction; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Postoperative Complications; Postoperative Nausea and Vomiting; Quaternary Ammonium Compounds | 2002 |
Methylnaltrexone reverses opioid-induced constipation.
Topics: Administration, Oral; Analgesics, Opioid; Clinical Trials, Phase II as Topic; Constipation; Humans; Methadone; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds | 2002 |
Differential antagonism of endomorphin-1 and endomorphin-2 supraspinal antinociception by naloxonazine and 3-methylnaltrexone.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Injections, Spinal; Male; Mice; Naloxone; Naltrexone; Oligopeptides; Pain; Pain Measurement; Quaternary Ammonium Compounds; Reflex; Time Factors | 2002 |
Determination of methylnaltrexone in clinical samples by solid-phase extraction and high-performance liquid chromatography for a pharmacokinetics study.
Topics: Calibration; Chromatography, High Pressure Liquid; Humans; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Reproducibility of Results; Sensitivity and Specificity | 2002 |
Methylnaltrexone antagonizes opioid-mediated enhancement of HIV infection of human blood mononuclear phagocytes.
Topics: Cells, Cultured; HIV Infections; HIV Reverse Transcriptase; Humans; Monocytes; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Quaternary Ammonium Compounds; Receptors, CCR5 | 2003 |
Opioid partial agonist effects of 3-O-methylnaltrexone in rhesus monkeys.
Topics: Adenylyl Cyclases; Animals; Cocaine; Discrimination Learning; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Heroin; Heroin Dependence; Macaca mulatta; Male; Morphine; Morphine Derivatives; Naltrexone; Narcotics; Quaternary Ammonium Compounds; Receptors, Opioid, mu; Self Administration | 2004 |
Methylnaltrexone prevents morphine-induced kaolin intake in the rat.
Topics: Animals; Antiemetics; Diet; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Injections, Intraperitoneal; Kaolin; Male; Morphine; Naltrexone; Narcotic Antagonists; Ondansetron; Pica; Quaternary Ammonium Compounds; Rats; Rats, Wistar | 2004 |
In vitro evaluation of the effect of the opioid antagonist N-methylnaltrexone on motility of the equine jejunum and pelvic flexure.
Topics: Analysis of Variance; Animals; Dose-Response Relationship, Drug; Gastrointestinal Motility; Horses; Jejunum; Muscle Contraction; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Pelvis; Quaternary Ammonium Compounds; Tissue Culture Techniques | 2005 |
The selective mu opioid receptor antagonist, alvimopan, improves delayed GI transit of postoperative ileus in rats.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Gastrointestinal Transit; Ileus; Laparotomy; Male; Naltrexone; Narcotic Antagonists; Piperidines; Postoperative Complications; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley | 2006 |
Pain management research goes beyond the obvious.
Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents; Constipation; Humans; Naltrexone; Narcotic Antagonists; Pain; Piperidines; Pyridines; Quaternary Ammonium Compounds; Receptors, Opioid, mu | 2006 |
The in vitro pharmacology of the peripherally restricted opioid receptor antagonists, alvimopan, ADL 08-0011 and methylnaltrexone.
Topics: Analgesics, Opioid; Animals; Benzeneacetamides; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Morphine; Muscle Contraction; Naltrexone; Narcotic Antagonists; Oligopeptides; Piperidines; Pyrrolidines; Quaternary Ammonium Compounds; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Proteins; Transfection | 2007 |
Attenuation of vascular permeability by methylnaltrexone: role of mOP-R and S1P3 transactivation.
Topics: Analgesics, Opioid; Animals; Capillary Permeability; Cells, Cultured; Electrophysiology; Endothelial Cells; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Humans; Intracellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Protein Serine-Threonine Kinases; Quaternary Ammonium Compounds; Receptors, Lysosphingolipid; Receptors, Opioid, mu; rho-Associated Kinases; rhoA GTP-Binding Protein; RNA, Small Interfering; Thrombin; Transcriptional Activation | 2007 |
Relistor approved for opioid-related constipation.
Topics: Analgesics, Opioid; Constipation; Drug Approval; Humans; Injections, Subcutaneous; Naltrexone; Narcotic Antagonists; Palliative Care; Quaternary Ammonium Compounds; Receptors, Opioid, mu; United States; United States Food and Drug Administration | 2008 |
Opioid side effects--mechanism-based therapy.
Topics: Analgesics, Opioid; Constipation; Humans; Laxatives; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds | 2008 |
The Food and Drug Administration approves methylnaltrexone bromide for opioid-induced constipation.
Topics: Analgesics, Opioid; Constipation; Drug Approval; Humans; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; United States; United States Food and Drug Administration | 2008 |
Synergistic effects of methylnaltrexone with 5-fluorouracil and bevacizumab on inhibition of vascular endothelial growth factor-induced angiogenesis.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Bevacizumab; Cell Movement; Cell Proliferation; Cells, Cultured; Drug Synergism; Endothelial Cells; Enzyme Activation; Fluorouracil; Guanine Nucleotide Exchange Factors; Humans; Models, Biological; Naltrexone; Neovascularization, Physiologic; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins pp60(c-src); Quaternary Ammonium Compounds; Receptor-Like Protein Tyrosine Phosphatases, Class 2; Repressor Proteins; rhoA GTP-Binding Protein; Vascular Endothelial Growth Factor A | 2008 |
Managing opioid-induced constipation.
Topics: Analgesics, Opioid; Constipation; Humans; Laxatives; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds | 2008 |
Methylnaltrexone (Relistor) for opioid induced constipation.
Topics: Analgesics, Opioid; Constipation; Drug Interactions; Humans; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Randomized Controlled Trials as Topic; Terminal Care | 2008 |
Methylnaltrexone, a new peripherally acting mu-opioid receptor antagonist being evaluated for the treatment of postoperative ileus.
Topics: Animals; Clinical Trials as Topic; Drug Evaluation; Humans; Ileus; Naltrexone; Postoperative Complications; Quaternary Ammonium Compounds; Receptors, Opioid, mu | 2008 |
Methylnaltrexone for opioid-induced constipation in advanced illness.
Topics: Analgesics, Opioid; Constipation; Drug Tolerance; Humans; Laxatives; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds | 2008 |
Methylnaltrexone for opioid-induced constipation in advanced illness.
Topics: Administration, Oral; Analgesics, Opioid; Constipation; Humans; Injections, Subcutaneous; Laxatives; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds | 2008 |
Reversal of opioid-induced gastric dysfunction in a critically ill burn patient after methylnaltrexone.
Topics: Adult; Analgesics, Opioid; Burns; Critical Illness; Enteral Nutrition; Gastric Emptying; Humans; Male; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds | 2008 |
Drug approvals: '08 in review. Methylnaltrexone (Relistor).
Topics: Analgesics, Opioid; Constipation; Humans; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds | 2009 |
Methylnaltrexone for opioid-induced constipation.
Topics: Analgesics, Opioid; Constipation; Humans; Injections, Subcutaneous; Naltrexone; Narcotic Antagonists; Quality of Life; Quaternary Ammonium Compounds | 2009 |
New drug update: 2008.
Topics: Animals; Anti-Allergic Agents; Antidepressive Agents; Antihypertensive Agents; Benzopyrans; Cyclohexanols; Desvenlafaxine Succinate; Ethanolamines; Humans; Naltrexone; Narcotic Antagonists; Nebivolol; Pregnenediones; Quaternary Ammonium Compounds | 2009 |
Preventing paralytic ileus: can the anesthesiologist help.
Topics: Analgesics, Opioid; Anesthetics; Gastrointestinal Agents; Humans; Intestinal Pseudo-Obstruction; Intubation, Gastrointestinal; Naltrexone; Piperidines; Postoperative Complications; Preoperative Care; Quaternary Ammonium Compounds | 2009 |
[Successful treatment of treatment-resistant opioid-induced constipation in a patient with incomplete paraplegia with methylnaltrexone].
Topics: Aged; Cervical Vertebrae; Constipation; Fecal Impaction; Humans; Injections, Subcutaneous; Male; Naltrexone; Narcotic Antagonists; Narcotics; Paraplegia; Postoperative Complications; Quaternary Ammonium Compounds; Spinal Cord Compression | 2009 |
Methylnaltrexone, a peripherally acting opioid receptor antagonist, enhances tumoricidal effects of 5-Fu on human carcinoma cells.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Proliferation; Colorectal Neoplasms; Cyclin A; Drug Synergism; Drug Therapy, Combination; Flow Cytometry; Fluorescein-5-isothiocyanate; Fluorouracil; Humans; Lung Neoplasms; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Tumor Cells, Cultured | 2009 |
Methylnaltrexone: new drug. Opiate-induced constipation: barely more effective than placebo.
Topics: Analgesics, Opioid; Clinical Trials as Topic; Constipation; Double-Blind Method; Drug Approval; Europe; Humans; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Terminally Ill | 2009 |
Methylnaltrexone: a subcutaneous treatment for opioid-induced constipation in palliative care patients.
Topics: Aged, 80 and over; Algorithms; Analgesics, Opioid; Causality; Constipation; Cost of Illness; Decision Trees; Female; Humans; Injections, Subcutaneous; Laxatives; Naltrexone; Narcotic Antagonists; Nursing Assessment; Palliative Care; Quaternary Ammonium Compounds | 2009 |
Methylnaltrexone bromide for the treatment of opioid-induced constipation in patients with advanced illness--a cost-effectiveness analysis.
Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Constipation; Cost-Benefit Analysis; Humans; Laxatives; Middle Aged; Naltrexone; Narcotic Antagonists; Quality-Adjusted Life Years; Quaternary Ammonium Compounds; Terminally Ill; Young Adult | 2010 |
Subcutaneous methylnaltrexone to restore postoperative bowel function in a long-term opiate user.
Topics: Analgesics, Opioid; Female; Heroin Dependence; Humans; Ileus; Injections, Subcutaneous; Middle Aged; Naltrexone; Narcotic Antagonists; Postoperative Complications; Quaternary Ammonium Compounds | 2010 |
In vitro metabolism and identification of human enzymes involved in the metabolism of methylnaltrexone.
Topics: Alcohol Oxidoreductases; Aldehyde Reductase; Aldo-Keto Reductases; Animals; Biocatalysis; Cytosol; Dogs; Enzyme Inhibitors; Enzymes; Haplorhini; Humans; Kinetics; Liver; Mass Spectrometry; Mice; Molecular Structure; NADP; Naltrexone; Oxidation-Reduction; Oxidoreductases; Quaternary Ammonium Compounds; Rats; Recombinant Proteins; Sulfotransferases; Sulfuric Acid Esters | 2010 |
Emerging new therapeutic options for the management of opioid induced constipation.
Topics: Alprostadil; Analgesics, Opioid; Constipation; Delayed-Action Preparations; Drug Therapy, Combination; Humans; Laxatives; Lubiprostone; Naloxone; Naltrexone; Narcotic Antagonists; Oxycodone; Quaternary Ammonium Compounds | 2010 |
Methylnaltrexone and gastrointestinal perforation.
Topics: Analgesics, Opioid; Humans; Intestinal Perforation; Naltrexone; Narcotic Antagonists; Palliative Care; Quaternary Ammonium Compounds; United States | 2010 |
Methylnaltrexone in the treatment of opioid-induced constipation in cancer patients receiving palliative care: willingness-to-pay and cost-benefit analysis.
Topics: Adolescent; Adult; Age Distribution; Analgesics, Opioid; Constipation; Consumer Behavior; Cost of Illness; Cost-Benefit Analysis; Female; Health Care Costs; Humans; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Neoplasms; Ontario; Pain; Palliative Care; Patient Acceptance of Health Care; Quaternary Ammonium Compounds; Sex Distribution; Socioeconomic Factors; Treatment Outcome; Young Adult | 2011 |
Endogenously released opioids mediate meal-induced gastric relaxation via peripheral mu-opioid receptors.
Topics: Adult; Analgesics, Opioid; Analysis of Variance; Eating; Female; Food; Humans; Male; Naloxone; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Receptors, Opioid, mu; Satiation; Stomach | 2011 |
Resolution of opioid-induced postoperative ileus in a newborn infant after methylnaltrexone.
Topics: Aortic Arch Syndromes; Coronary Disease; Extracorporeal Membrane Oxygenation; Fatal Outcome; Female; Fentanyl; Humans; Infant, Newborn; Intestinal Pseudo-Obstruction; Naltrexone; Narcotic Antagonists; Narcotics; Pain, Postoperative; Postoperative Complications; Quaternary Ammonium Compounds; Remission Induction | 2011 |
Methylnaltrexone: treatment for opioid-induced constipation--not convinced yet.
Topics: Analgesics, Opioid; Constipation; Humans; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds | 2011 |
Treating constipation in palliative care: the impact of other factors aside from opioids.
Topics: Aged; Analgesics, Opioid; Constipation; Female; Humans; Laxatives; Male; Medical Records; Middle Aged; Naltrexone; Narcotic Antagonists; Neoplasms; New South Wales; Outcome Assessment, Health Care; Palliative Care; Quaternary Ammonium Compounds; Risk Factors | 2012 |
Methylnaltrexone in treatment of opioid-induced constipation in a pediatric patient.
Topics: Analgesics, Opioid; Child, Preschool; Chronic Pain; Constipation; Humans; Male; Naltrexone; Narcotic Antagonists; Pediatrics; Quaternary Ammonium Compounds | 2012 |
Quantitative determination of methylnaltrexone in human serum using liquid chromatography-tandem mass spectrometry.
Topics: Chromatography, Liquid; Humans; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Reproducibility of Results; Tandem Mass Spectrometry | 2011 |
Arresting the development of morphine tolerance and dependence.
Topics: Analgesics; Animals; Drug Tolerance; Humans; Ketamine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Ondansetron; Pain; Polypharmacy; Quaternary Ammonium Compounds; Serotonin Antagonists | 2011 |
Reversal of morphine-induced urinary retention after methylnaltrexone.
Topics: Analgesics, Opioid; Humans; Infant, Newborn; Male; Morphine; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Ultrasonography; Urinary Retention | 2012 |
Management of constipation in patients receiving palliative care.
Topics: Analgesics, Opioid; Constipation; Humans; Laxatives; Naltrexone; Narcotic Antagonists; Pain; Palliative Care; Quaternary Ammonium Compounds | 2011 |
Effects of methylnaltrexone in patients with narcotic bowel syndrome: a pilot observational study.
Topics: Abdominal Pain; Adult; Female; Humans; Middle Aged; Naltrexone; Narcotic Antagonists; Narcotics; Pilot Projects; Prospective Studies; Quaternary Ammonium Compounds; Syndrome; Treatment Outcome | 2012 |
Management of postoperative ileus.
Topics: Combined Modality Therapy; Exercise Therapy; Gastrointestinal Agents; Humans; Ileus; Naltrexone; Narcotic Antagonists; Piperidines; Postoperative Complications; Quaternary Ammonium Compounds | 2012 |
Use of methylnaltrexone for the treatment of opioid-induced constipation in critical care patients.
Topics: Aged; Analgesics, Opioid; Constipation; Critical Care; Female; Gastrointestinal Motility; Humans; Laxatives; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Retrospective Studies; Statistics, Nonparametric | 2012 |
Non-analgesic effects of opioids: management of opioid-induced constipation by peripheral opioid receptor antagonists: prevention or withdrawal?
Topics: Age Factors; Analgesics, Opioid; Constipation; Defecation; Drug Combinations; Gastrointestinal Tract; Humans; Laxatives; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Predictive Value of Tests; Prevalence; Quaternary Ammonium Compounds; Receptors, Opioid; Risk Factors | 2012 |
Methylnaltrexone for opioid-induced constipation in a pediatric oncology patient.
Topics: Analgesics, Opioid; Brain Neoplasms; Child; Constipation; Female; Humans; Morphine; Naltrexone; Narcotic Antagonists; Neuroblastoma; Pain; Quaternary Ammonium Compounds | 2012 |
An unusual case of Ogilvie syndrome in a pediatric oncology patient receiving palliative care after failed treatment with neostigmine.
Topics: Adolescent; Cholinesterase Inhibitors; Colonic Pseudo-Obstruction; Colonoscopy; Diagnosis, Differential; Fatal Outcome; Female; Humans; Ileostomy; Naltrexone; Narcotic Antagonists; Neostigmine; Osteosarcoma; Palliative Care; Quaternary Ammonium Compounds; Sarcoma, Small Cell; Treatment Failure | 2012 |
Subsidised use of methylnaltrexone in Australia for palliative care.
Topics: Analgesics, Opioid; Australia; Constipation; Drug Utilization; Humans; Laxatives; Naltrexone; Narcotic Antagonists; Palliative Care; Quaternary Ammonium Compounds | 2012 |
WYE-120318, a ring contraction product of methylnaltrexone, and structure revision of coniothyrione.
Topics: Catalysis; Chromatography, High Pressure Liquid; Chromones; Dimerization; Magnetic Resonance Spectroscopy; Naltrexone; Quaternary Ammonium Compounds; Stereoisomerism | 2012 |
Bioavailability of oral methylnaltrexone increases with a phosphatidylcholine-based formulation.
Topics: Administration, Oral; Animals; Biological Availability; Chemistry, Pharmaceutical; Gastrointestinal Tract; Male; Naltrexone; Narcotic Antagonists; Phosphatidylcholines; Quaternary Ammonium Compounds; Random Allocation; Rats; Rats, Sprague-Dawley; X-Ray Diffraction | 2014 |
Effects of methylnaltrexone on guinea pig gastrointestinal motility.
Topics: Animals; Gastrointestinal Motility; Gastrointestinal Tract; Guinea Pigs; Male; Morphine; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Receptors, Opioid, mu | 2013 |
Opiate receptor antagonists for treatment of severe pruritus associated with advanced cholestatic liver disease.
Topics: Aged, 80 and over; Cholestasis; Comorbidity; Humans; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pruritus; Quality of Life; Quaternary Ammonium Compounds | 2013 |
The in vitro pharmacological profile of TD-1211, a neutral opioid receptor antagonist.
Topics: Animals; Benzamides; CHO Cells; Cricetinae; Cricetulus; Guinea Pigs; Humans; In Vitro Techniques; Male; Mesocricetus; Naltrexone; Narcotic Antagonists; Piperidines; Quaternary Ammonium Compounds; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tropanes | 2013 |
Methylnaltrexone use in a seventeen-month-old female with progressive cancer and rectal prolapse.
Topics: Analgesics, Opioid; Constipation; Female; Humans; Infant; Leukemia, Myeloid, Acute; Naltrexone; Narcotic Antagonists; Palliative Care; Quaternary Ammonium Compounds; Rectal Prolapse | 2013 |
Pharmacologic treatment of opioid-induced constipation.
Topics: Analgesics, Opioid; Clinical Trials, Phase III as Topic; Constipation; Humans; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Receptors, Opioid, mu | 2013 |
Unexpected side effect of methylnaltrexone.
Topics: Aged; Constipation; Female; Humans; Naltrexone; Narcotic Antagonists; Palliative Care; Quaternary Ammonium Compounds; Vomiting | 2013 |
The role of methylnaltrexone in opioid-induced constipation.
Topics: Analgesics, Opioid; Constipation; Humans; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds | 2013 |
Uptake of methylnaltrexone in Australian patients with opioid-induced constipation: a review of the number of prescriptions presented in the first 12 months of subsidisation.
Topics: Analgesics, Opioid; Australia; Constipation; Humans; Naltrexone; Narcotic Antagonists; Needs Assessment; Palliative Care; Prescriptions; Quaternary Ammonium Compounds | 2013 |
Paediatric palliative care: intravenous methylnaltrexone relieves constipation.
Topics: Administration, Intravenous; Analgesics, Opioid; Child, Preschool; Constipation; Heroin; Humans; Male; Naltrexone; Narcotic Antagonists; Palliative Care; Quaternary Ammonium Compounds | 2013 |
GI relief may come sooner than later for patients with chronic noncancer pain.
Topics: Adult; Analgesics, Opioid; Chronic Pain; Constipation; Drug Approval; Humans; Morphinans; Naltrexone; Narcotic Antagonists; Polyethylene Glycols; Quaternary Ammonium Compounds; United States; United States Food and Drug Administration | 2014 |
Off-label uses of alvimopan and methylnaltrexone.
Topics: Analgesics, Opioid; Constipation; Gastrointestinal Agents; Humans; Ileus; Naltrexone; Narcotic Antagonists; Off-Label Use; Piperidines; Postoperative Complications; Quaternary Ammonium Compounds | 2014 |
Narcotic-induced pain.
Topics: Abdominal Pain; Adult; Analgesics, Opioid; Anorexia; Chronic Disease; Diabetes Mellitus, Type 1; Drug Administration Schedule; Endoscopy, Gastrointestinal; Gastroparesis; Humans; Hypertension; Kidney Failure, Chronic; Male; Naltrexone; Narcotic Antagonists; Nausea; Neuralgia; Quaternary Ammonium Compounds; Substance Withdrawal Syndrome; Treatment Outcome; Vomiting | 2015 |
Peripheral opioid antagonist enhances the effect of anti-tumor drug by blocking a cell growth-suppressive pathway in vivo.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Cycle; Cell Proliferation; Docetaxel; Drug Synergism; Growth Inhibitors; Humans; Mice; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Receptors, Opioid; Stomach Neoplasms; Taxoids | 2015 |
Methylnaltrexone for opioid-induced constipation in patients at the end of life.
Topics: Analgesics, Opioid; Constipation; Humans; Naltrexone; Quaternary Ammonium Compounds; Terminal Care | 2015 |
Methylnaltrexone for Opioid-Induced Constipation in Children and Adolescents and Young Adults with Progressive Incurable Cancer at the End of Life.
Topics: Adolescent; Analgesics, Opioid; Child; Child, Preschool; Constipation; Double-Blind Method; Female; Humans; Infant; Male; Medical Audit; Naltrexone; Narcotic Antagonists; Neoplasms; Quaternary Ammonium Compounds; Retrospective Studies; Terminally Ill; Young Adult | 2015 |
Morphine Modulates Interleukin-4- or Breast Cancer Cell-induced Pro-metastatic Activation of Macrophages.
Topics: Animals; Arginase; Bone Marrow Cells; Cell Differentiation; Cell Line; Cell Line, Tumor; Cell Movement; Coculture Techniques; Female; Gene Expression Regulation, Neoplastic; Humans; Interleukin-4; Macrophage Activation; Macrophages; Mammary Glands, Animal; Matrix Metalloproteinase 9; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Morphine; Naloxone; Naltrexone; Quaternary Ammonium Compounds; Receptors, Cell Surface; Receptors, Immunologic; Signal Transduction | 2015 |
Methylnaltrexone to Palliate Pruritus in Terminal Hepatic Disease.
Topics: Aged; Carcinoma, Hepatocellular; Fatal Outcome; Female; Gallbladder Neoplasms; Hepatitis C; Humans; Liver Cirrhosis; Liver Neoplasms; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Pain Measurement; Pruritus; Quaternary Ammonium Compounds; Terminal Care | 2015 |
Opioid-Induced Constipation Part 2: Newer Therapies #295.
Topics: Analgesics, Opioid; Constipation; Humans; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Polyethylene Glycols; Quaternary Ammonium Compounds | 2015 |
Methylnaltrexone for the Treatment of Constipation in Critically Ill Children.
Topics: Abdominal Pain; Analgesics, Opioid; Child; Constipation; Critical Illness; Defecation; Humans; Infant; Laxatives; Male; Morphine; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Treatment Outcome | 2016 |
Loss of μ opioid receptor signaling in nociceptors, but not microglia, abrogates morphine tolerance without disrupting analgesia.
Topics: Analgesia; Analgesics, Opioid; Animals; Chronic Pain; Disease Models, Animal; Drug Tolerance; Gene Deletion; Hyperalgesia; Long-Term Potentiation; Mice; Mice, Knockout; Microglia; Morphine; Naltrexone; Nociception; Nociceptors; Pain, Postoperative; Quaternary Ammonium Compounds; Receptors, Opioid, mu; Signal Transduction; Spinal Cord | 2017 |
Methylnaltrexone Versus Naloxone for Opioid-Induced Constipation in the Medical Intensive Care Unit.
Topics: Adult; Analgesics, Opioid; Constipation; Critical Illness; Electronic Health Records; Female; Fentanyl; Heart Rate; Humans; Intensive Care Units; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Prospective Studies; Quaternary Ammonium Compounds; Retrospective Studies | 2017 |
Naloxegol, an opioid antagonist with reduced CNS penetration: Mode-of-action and human relevance for rat testicular tumours.
Topics: Animals; Biomarkers; Blood-Brain Barrier; Capillary Permeability; Dogs; Female; Humans; Leydig Cell Tumor; Luteinizing Hormone; Male; Mice; Morphinans; Naltrexone; Narcotic Antagonists; Polyethylene Glycols; Quaternary Ammonium Compounds; Rabbits; Rats, Sprague-Dawley; Risk Assessment; Species Specificity; Testicular Neoplasms; Testosterone; Time Factors; Toxicity Tests; Up-Regulation | 2017 |
The Role of Endogenous Opioid System in the Regulation of Heart Tolerance to Stress-Induced Damage.
Topics: Animals; Heart; Male; Naltrexone; Narcotic Antagonists; Opioid Peptides; Quaternary Ammonium Compounds; Rats; Rats, Wistar; Receptors, Opioid; Stress, Physiological | 2017 |
Role of central versus peripheral opioid system in antinociceptive and anti-inflammatory effect of botulinum toxin type A in trigeminal region.
Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents; Botulinum Toxins, Type A; Dura Mater; Male; Migraine Disorders; Morphine; Naltrexone; Narcotic Antagonists; Neurogenic Inflammation; Neuromuscular Agents; Nociception; Pain; Pain Measurement; Quaternary Ammonium Compounds; Rats; Rats, Wistar; Sciatic Nerve; Trigeminal Caudal Nucleus; Trigeminal Nerve | 2018 |
The effects of recurrent hypoglycaemia and opioid antagonists on the adrenal catecholamine synthetic capacity in a rat model of HAAF.
Topics: Animals; Blood Glucose; Disease Models, Animal; Epinephrine; Hypoglycemia; Hypoglycemic Agents; Insulin; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pure Autonomic Failure; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley; Serine; Tyrosine 3-Monooxygenase | 2018 |
Identification of oxymorphone as decomposition product of the permitted drug methylnaltrexone.
Topics: Doping in Sports; Drug Stability; Gas Chromatography-Mass Spectrometry; Humans; Naltrexone; Narcotic Antagonists; Narcotics; Oxymorphone; Quaternary Ammonium Compounds; Substance Abuse Detection | 2018 |
Attenuation of serotonin-induced itch by sumatriptan: possible involvement of endogenous opioids.
Topics: Animals; Disease Models, Animal; Drug Therapy, Combination; Humans; Injections, Intradermal; Male; Mice; Naltrexone; Narcotic Antagonists; Opioid Peptides; Oxadiazoles; Piperazines; Pruritus; Quaternary Ammonium Compounds; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin 5-HT1 Receptor Agonists; Serotonin Antagonists; Sumatriptan | 2018 |
Methylation Products of 6β- N-Heterocyclic Substituted Naltrexamine Derivatives as Potential Peripheral Opioid Receptor Modulators.
Topics: Analgesics, Opioid; Animals; CHO Cells; Constipation; Cricetulus; Diarrhea; Drug Partial Agonism; Gastrointestinal Agents; Gastrointestinal Transit; Imidazoles; Methylation; Mice; Molecular Docking Simulation; Morphine; Naltrexone; Narcotic Antagonists; Nociception; Phenylalanine; Quaternary Ammonium Compounds; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2018 |
Methylnaltrexone-Associated Bowel Perforation in Postoperative Opioid-Induced Constipation and Ogilvie Syndrome: A Case Report.
Topics: Analgesics, Opioid; Colonic Pseudo-Obstruction; Constipation; Decompression, Surgical; Humans; Hydromorphone; Intestinal Perforation; Low Back Pain; Male; Methadone; Middle Aged; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Oxycodone; Postoperative Complications; Quaternary Ammonium Compounds; Spinal Stenosis | 2019 |
Optimal treatment of opioid induced constipation in daily clinical practice - an observational study.
Topics: Aged; Analgesics, Opioid; Constipation; Female; Fentanyl; Humans; Laxatives; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Neoplasms; Oxycodone; Pain Management; Prospective Studies; Quaternary Ammonium Compounds; Retrospective Studies; Surveys and Questionnaires | 2019 |
Methylnaltrexone is safe in cancer patients with peritoneal carcinomatosis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Child; Child, Preschool; Constipation; Female; Humans; Infant; Male; Middle Aged; Naltrexone; Peritoneal Neoplasms; Quaternary Ammonium Compounds; Retrospective Studies; Treatment Outcome; Young Adult | 2019 |
Methylnaltrexone to Reduce the Inhibitory Effects of Opioids on Drug Absorption.
Topics: Analgesics, Opioid; Coronary Artery Disease; Humans; Morphine; Naltrexone; Quaternary Ammonium Compounds; Ticagrelor; Treatment Outcome | 2019 |
The association between N-methylnaltrexone, a peripherally acting mu-opioid receptor antagonist, and clinical outcomes in patients undergoing robotic-assisted radical cystectomy.
Topics: Aged; Cystectomy; Female; Humans; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Postoperative Complications; Postoperative Period; Quaternary Ammonium Compounds; Retrospective Studies; Robotic Surgical Procedures; Treatment Outcome; Urinary Bladder Neoplasms | 2020 |
Antagonism of peripheral opioid receptors by methylnaltrexone does not prevent morphine tolerance in rats.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Male; Morphine; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, mu | 2022 |
Naloxegol rescue with methylnaltrexone highly effective.
Topics: Analgesics, Opioid; Female; Humans; Middle Aged; Morphinans; Naltrexone; Narcotic Antagonists; Opioid-Induced Constipation; Palliative Care; Polyethylene Glycols; Quality of Life; Quaternary Ammonium Compounds | 2020 |
Methylnaltrexone crosses the blood-brain barrier and attenuates centrally-mediated behavioral effects of morphine and oxycodone in mice.
Topics: Analgesics, Opioid; Animals; Blood-Brain Barrier; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred C57BL; Morphine; Naltrexone; Narcotic Antagonists; Oxycodone; Pain Measurement; Quaternary Ammonium Compounds | 2021 |
Low doses of methylnaltrexone inhibits head and neck squamous cell carcinoma growth in vitro and in vivo by acting on the mu-opioid receptor.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Cell Proliferation; Epithelial-Mesenchymal Transition; Head and Neck Neoplasms; Humans; Male; Mice, Inbred C57BL; Mice, Nude; Naltrexone; Narcotic Antagonists; Neoplasm Invasiveness; Quaternary Ammonium Compounds; Receptors, Opioid, mu; Signal Transduction; Squamous Cell Carcinoma of Head and Neck; Tumor Burden; Xenograft Model Antitumor Assays | 2021 |
The Efficacy and Safety of Methylnaltrexone for the Treatment of Postoperative Ileus.
Topics: Female; Humans; Ileus; Intestinal Perforation; Intubation, Gastrointestinal; Length of Stay; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Parenteral Nutrition; Postoperative Complications; Quaternary Ammonium Compounds; Retrospective Studies; Time Factors; Treatment Outcome | 2022 |
Naloxone Versus Methylnaltrexone for Opioid-Induced Constipation in Critically Ill Patients.
Topics: Adult; Analgesics, Opioid; Constipation; Critical Illness; Humans; Naloxone; Naltrexone; Narcotic Antagonists; Opioid-Induced Constipation; Pain; Prospective Studies; Quaternary Ammonium Compounds; Retrospective Studies | 2023 |