naltrexone and heroin

naltrexone has been researched along with heroin in 122 studies

Research

Studies (122)

Timeframe	Studies, this research(%)	All Research%
pre-1990	27 (22.13)	18.7374
1990's	25 (20.49)	18.2507
2000's	40 (32.79)	29.6817
2010's	22 (18.03)	24.3611
2020's	8 (6.56)	2.80

Authors

Authors	Studies
Callahan, EJ; Glazer, M; Liberman, RP; Rawson, RA	1
Ellingboe, J; Kuehnle, J; Mello, NK; Mendelson, JH	1
Altman, JL; Meyer, RE; Mirin, SM	1
Barrington, C; Greenberg, I; Meyer, R; Mirin, S; Randall, R	1
Julius, D	1
Cho, D; James, B; Mallya, A; Pevnick, J; Reker, D; Volavka, J	1
Mulé, SJ; Resnick, RB; Verebey, K; Volavka, J	1
McNamee, HB; Meyer, RE; Mirin, SM	1
Drummond, DC; Turkington, D	1
Cammera, P; Griffiths, W; Swift, RM	1
Brogden, RN; Gonzalez, JP	1
Coen, KM; Corrigall, WA; Herling, S	1
Peachey, JE	1
Brewer, C	3
Nawiesniak, E; Schenk, S	1
Corrigall, WA; Vaccarino, FJ	2
Kleber, HD; Kosten, TR; Vining, E	1
Corrigall, WA	1
Gaspari, J; Kleber, HD; Kosten, T; Riordan, CE; Topazian, M	1
Moerschbaecher, JM; Thompson, DM; Winsauer, PJ	1
Bloom, FE; Ettenberg, A; Koob, GF; Pettit, HO	2
Angel, L; Inturrisi, CE; Schultz, M; Shin, S; Simon, EJ; Umans, JG	1
Ellingboe, J; Kuehnle, JC; Mendelson, JH	1
Bennett, SA; Roberts, DC	1
Dworkin, SI; Martin, TJ; Smith, JE	2
Jamaludin, A; Mansor, SM; Mohamed, M; Navaratnam, V; Raman, N	1
Fujimoto, JM; Portoghese, PS; Rady, JJ; Takemori, AE	1
Baldelli, C; Benincasa, E; De Luca, A; Domenici, B; Galante, A; Pietroiusti, A; Tiratterra, F; Valenzi, C	1
Henriksen, SJ; Koob, GF; Mattox, A; Negus, SS; Pasternak, GW; Portoghese, PS; Takemori, AE; Weinger, MB	1
Galloway, G	1
Dworkin, SI; Hemby, SE; Smith, JE	1
Dworkin, SI; Martin, TJ; Sizemore, GM; Smith, JE; Walker, LE	1
Shaham, Y; Stewart, J	1
Hajak, G; Poser, W; Rodenbeck, A; Rüther, E; Staedt, J; Stoppe, G; Wassmuth, F	1
Capodano, RJ; Gaeta, TJ; Spevack, TA	1
Brown, GP; Chang, A; King, MA; Leventhal, L; Pasternak, GW; Rossi, GC; Yang, K	1
Carroll, KM; Kosten, TR; O'Connor, PG; Rounsaville, BJ; Schottenfeld, RS; Shi, JM	1
Hoehn-Saric, R; Legl, T; Lehofer, M; Liebmann, PM; Moser, M; Pernhaupt, G; Schauenstein, K	1
Caplehorn, JR	1
Hall, W; Mattick, RP	1
Byrne, A	1
Rowlett, JK; Wilcox, KM; Woolverton, WL	1
DeMontis, MG; Dworkin, SI; Kim, SA; Martin, TJ; Sizemore, GM; Smith, JE	1
Fujimoto, JM; Gorny, JM; Rady, JJ	1
Bammer, G; Bell, JR; Masterman, SC; Mattick, RP; Morris, A; Young, MR	1
Chiang, CT; Demuth, KL; Hoover, DR; Montoya, ID; Preston, KL; Umbricht, A	1
Izzo, E; King, M; Koob, GF; Pasternak, GW; Walker, JR	1
How, T; Lysle, DT	1
Fecho, K; Lysle, DT; Nelson, CJ	1
Fujimoto, JM; Holmes, BB; Portoghese, PS; Rady, JJ	1
Kishioka, S; Paronis, CA; Woods, JH	1
Fecho, K; Lysle, DT	1
Platt, DM; Rowlett, JK; Spealman, RD	2
Bian, D; Cannon, DG; Kim, SA; Martin, TJ; Porreca, F; Sizemore, GM; Smith, JE	1
Fujimura, T; Hayashi, T; Kastin, AJ; Murayama, K; Sakurada, C; Sakurada, S; Sakurada, T; Takeshita, M; Yonezawa, A; Yuhki, M; Zadina, JE	1
Boto, I; Gomes, PC; Henriques, V; Macedo, TR; Morgadinho, MT; Nunes, SV; Pacheco, F; Pinto, CM; Ramalheira, C; Relvas, J; Ruis, GR; Vale, LL; Ventura, M	1
Bristow, K; Clark, N; Meek, R	1
Collins, ED; Comer, SD; Fischman, MW; Kerrigan, JH; Kleber, HD; Nuwayser, ES	1
Brandt, MR; France, CP; Galici, R	1
Kim, SA; Lyupina, Y; Martin, TJ; Smith, JE	1
Bowen, CA; Fischer, BD; Mello, NK; Negus, SS	1
Blahoutová, V; Holán, V; Krulova, M; Wilczek, H; Zajícová, A	1
Brandt, MR; Gatch, MB; Mello, NK; Negus, SS	1
Brewer, C; Foster, J; Steele, T	1
Arnold-Reed, DE; Basso, MR; Hansson, RC; Holman, CD; Hulse, GK; Murray, SD; O'Neil, G	1
Izenwasser, S; Platt, DM; Rowlett, JK; Spealman, RD	1
Ali, R; Athanasos, P; Danz, C; Gowing, L; McGregor, C; Stegink, A; Thomas, P; White, J	1
Castellano, M; Cervera, G; Martínez-Raga, J; Perez-Galvez, B; Sabater, A	1
Beaini, AY; Carr, MP; Firth, AY; Pulling, S	1
Beer, A; Huleihel, R; Izrael, M; Katz, S; Levi, Y; Rozenboim, I; Slotkin, TA; Yanai, J; Yaniv, SP	1
Goldberg, SR; Solinas, M	1
Antonilli, L; Badiani, A; Caprioli, D; Nencini, P; Petecchia, E	1
Dickinson, A; Everitt, BJ; Hellemans, KG	1
Comer, SD; Sullivan, MA; Vosburg, SK	1
Bespalov, AY; Burakov, AM; Didenko, TY; Egorova, VY; Grinenko, AY; Ivanova, EB; Krupitsky, EM; Masalov, DV; Neznanov, NG; O'Brien, CP; Romanova, TN; Tsoy, MV; Verbitskaya, EV; Woody, GE; Zvartau, EE	1
Bluschke, SM; De Jong, CA; Dijkstra, BA; Krabbe, PF; van der Staak, CP	1
Co, C; Coller, M; Martin, TJ; Smith, JE	1
Hulse, GK; Tait, RJ	1
Becker, GL; France, CP; Gerak, LR; Li, JX; McMahon, LR	1
Antonilli, L; Badiani, A; Brusadin, V; Graziani, M; Nencini, P; Togna, AR; Togna, G; Viola, S	1
Antonilli, L; Badiani, A; Brusadin, V; Milella, MS; Nencini, P; Sobrero, F	1
Kalivas, PW; Lai, M; Liu, H; Tang, S; Zhang, F; Zhou, W; Zhu, H	1
Achat-Mendes, C; Platt, DM; Rowlett, JK; Spealman, RD; Valdez, GR	1
Matulonis, JE; Pan, YX; Pasternak, GW; Rossi, GC; Xu, J; Xu, M	1
Philibin, SD; Porter, JH; Vann, RE; Varvel, SA; Walentiny, DM; Wise, LE	1
Amar, R; Casarella, J; Drexler, K; Fareed, A; Vayalapalli, S	1
Buechler, NL; Childers, SR; Ewan, EE; Kim, SA; Martin, TJ; Xiao, R	1
Comer, SD; Eaton, TA; Katz, NP; Revicki, DA; Stauffer, JW; Trudeau, JJ; van Inwegen, RG	1
Baumann, MH; Bossert, JM; Hutchinson, MR; Kambhampati, S; Li, X; Pickens, CL; Rice, KC; Shaham, Y; St Laurent, R; Theberge, FR; Watkins, LR	1
Duffy, S; Glanville, JM; Godfrey, C; Hewitt, C; Martyn-St James, M; McCool, R; Neilson, M; Perry, AE	1
Chohan, O; Mayer, A; Yeomanson, D	1
Andersen, JM; Boix, F; Eriksen, GS; Mørland, J	1
Courchesne, S; Eigenmann, K; Gelinas, J; Schouela, N; Sedki, F; Shalev, U	1
Bawor, M; Bonner, A; Daiter, J; Dennis, BB; Desai, D; Marsh, DC; Naji, L; Pare, G; Plater, C; Samaan, Z; Thabane, L; Varenbut, M; Worster, A	1
Fürst, Z; Hosztafi, S	1
Glanville, JM; Godfrey, C; Hewitt, C; Martyn-St James, M; Neilson, M; Perry, AE; Woodhouse, R	1
Farré-Albaladejo, M; Fernández-Nieva, Z; Gascón-Crespí, I; Hernández, RM; Igartua, M; Moreno-Vicente, R; Navarro, A; Pedraz, JL	1
Cucciare, MA; Garrison-Diehn, C; Schultz, NR; Timko, C; Vittorio, L	1
Daniels, S; Leri, F; Marshall, P	1
Ayranci, G; Befort, K; Filliol, D; Gavériaux-Ruff, C; Kieffer, BL; Lalanne, L; Lutz, PE	1
Booij, J; Goudriaan, AE; Koeter, MW; van den Brink, W; Zaaijer, ER	1
Berry, MS; Bigelow, GE; Fingerhood, M; Holtyn, AF; Jarvis, BP; Silverman, K; Subramaniam, S; Umbricht, A	1
Bal, C; Posch, C; Rappersberger, K	1
Giancola, JB; Keighron, JD; Lin, SC; Newman, AH; Scaglione, A; Tanda, G; Zanettini, C	1
Dean, RL; Heal, DJ; Smith, SL; Todtenkopf, MS	1
Katz, JL; Tanda, G; Yue, K; Zanettini, C	1
Bigelow, GE; DeFulio, A; Fingerhood, M; Holtyn, AF; Jarvis, BP; Koffarnus, MN; Leoutsakos, JS; Silverman, K; Umbricht, A	1
Banks, ML; Blake, S; Bremer, PT; Negus, SS; Poklis, JL; Schwienteck, KL; Townsend, EA	1
Baidoo, N; Huff, AE; Jardine, KH; Leri, F; Pulles, Z; Winters, BD; Wolter, M	1
Banks, ML; Bremer, PT; Faunce, KE; Janda, KD; Jaster, AM; Negus, SS; Robinson, HL; Townsend, EA	1
Jin, Z; Kim, K; Zhan, CG; Zhang, CH; Zheng, F	1
Flynn, SM; France, CP	1
Beas, I; Bromley, E; Hunter, SB; Hurley, B; Leamon, I; Martinez, J; McCreary, M; McCullough, CM; Montero, A; Ober, AJ; Sheehe, J; Tarn, DM; Watkins, KE	1
Akerman, SC; Barbieri, V; Bisaga, A; Fratantonio, J; Hu, MC; Nunes, EV; Shulman, M; Sullivan, MA	1
Ding, H; Kiguchi, N; Kishioka, S; Ko, MC; Mabry, KM	1

Reviews

8 review(s) available for naltrexone and heroin

Article	Year
NIDA's naltrexone research program. NIDA research monograph, 1976, Issue:9 Topics: Clinical Trials as Topic; Conditioning, Psychological; Cyclazocine; Drug Evaluation; Euphoria; Heroin; Heroin Dependence; Humans; Naloxone; Naltrexone; Narcotic Antagonists; Research; Research Support as Topic; United States; United States Substance Abuse and Mental Health Services Administration	1976
Naltrexone. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy in the management of opioid dependence. Drugs, 1988, Volume: 35, Issue:3 Topics: Animals; Heroin; Heroin Dependence; Humans; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Receptors, Opioid	1988
Heroin anticraving medications: a systematic review. The American journal of drug and alcohol abuse, 2010, Volume: 36, Issue:6 Topics: Buprenorphine; Heroin; Heroin Dependence; Humans; Methadone; Naltrexone; Narcotic Antagonists; Narcotics; Opiate Substitution Treatment; Opioid-Related Disorders; Randomized Controlled Trials as Topic; Substance Withdrawal Syndrome	2010
Pharmacological interventions for drug-using offenders. The Cochrane database of systematic reviews, 2013, Dec-19, Issue:12 Topics: Adult; Buprenorphine; Criminals; Female; Heroin; Humans; Male; Methadone; Naltrexone; Narcotics; Randomized Controlled Trials as Topic; Substance-Related Disorders	2013
[Therapy in heroin addiction]. Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology, 2014, Volume: 16, Issue:3 Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Buprenorphine; Euphoria; Heroin; Heroin Dependence; Humans; Methadone; Naltrexone; Narcotic Antagonists; Narcotics; Opiate Substitution Treatment	2014
Pharmacological interventions for drug-using offenders. The Cochrane database of systematic reviews, 2015, Jun-02, Issue:6 Topics: Adult; Buprenorphine; Crime; Criminals; Female; Heroin; Humans; Male; Methadone; Naltrexone; Narcotics; Opiate Substitution Treatment; Randomized Controlled Trials as Topic; Substance-Related Disorders	2015
Retention in medication-assisted treatment for opiate dependence: A systematic review. Journal of addictive diseases, 2016, Volume: 35, Issue:1 Topics: Behavior Therapy; Buprenorphine; Heroin; Humans; Methadone; Naltrexone; Narcotic Antagonists; Narcotics; Opiate Substitution Treatment; Opioid-Related Disorders; Randomized Controlled Trials as Topic; Treatment Outcome	2016
Adverse effects of subcutaneous, drug-releasing implants for the treatment of opioid drug addiction. Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 2017, Volume: 15, Issue:12 Topics: Adult; Device Removal; Drug Eruptions; Drug Implants; Heroin; Heroin Dependence; Humans; Male; Naltrexone; Prostheses and Implants	2017

Trials

16 trial(s) available for naltrexone and heroin

Article	Year
Limitations of an extinction approach to narcotic antagonist treatment. NIDA research monograph, 1976, Issue:9 Topics: Aftercare; Age Factors; Clinical Trials as Topic; Conditioning, Psychological; Drug Administration Schedule; Extinction, Psychological; Follow-Up Studies; Heroin; Heroin Dependence; Humans; Naltrexone; Narcotic Antagonists; Research Design; Self Administration; Time Factors	1976
NIDA's naltrexone research program. NIDA research monograph, 1976, Issue:9 Topics: Clinical Trials as Topic; Conditioning, Psychological; Cyclazocine; Drug Evaluation; Euphoria; Heroin; Heroin Dependence; Humans; Naloxone; Naltrexone; Narcotic Antagonists; Research; Research Support as Topic; United States; United States Substance Abuse and Mental Health Services Administration	1976
Clinical evaluation of naltrexone treatment of opiate-dependent individuals. Report of the National Research Council Committee on Clinical Evaluation of Narcotic Antagonists. Archives of general psychiatry, 1978, Volume: 35, Issue:3 Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; Heroin; Heroin Dependence; Humans; Male; Methadone; Motivation; Naloxone; Naltrexone; Patient Compliance; Placebos; Research Design; Social Adjustment	1978
EEG and other effects of naltrexone and heroin in man. Pharmakopsychiatrie, Neuro-Psychopharmakologie, 1979, Volume: 12, Issue:1 Topics: Auditory Threshold; Circadian Rhythm; Electroencephalography; Electrooculography; Heroin; Heroin Dependence; Humans; Male; Naloxone; Naltrexone; Time Factors	1979
Determination of naltrexone dosage for narcotic agonist blockade in detoxified Asian addicts. Drug and alcohol dependence, 1994, Volume: 34, Issue:3 Topics: Adult; Arousal; Cross-Cultural Comparison; Dose-Response Relationship, Drug; Double-Blind Method; Heroin; Heroin Dependence; Humans; Malaysia; Male; Naltrexone; Neurologic Examination; Receptors, Opioid; Substance Abuse, Intravenous	1994
Three methods of opioid detoxification in a primary care setting. A randomized trial. Annals of internal medicine, 1997, Oct-01, Volume: 127, Issue:7 Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Buprenorphine; Clonidine; Double-Blind Method; Drug Therapy, Combination; Female; Heroin; Heroin Dependence; Humans; Inactivation, Metabolic; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Primary Health Care; Substance Withdrawal Syndrome	1997
A pilot study of naltrexone-accelerated detoxification in opioid dependence. The Medical journal of Australia, 1999, Jul-05, Volume: 171, Issue:1 Topics: Adolescent; Adult; Analgesics; Anti-Anxiety Agents; Clonidine; Conscious Sedation; Female; Flunitrazepam; Heroin; Heroin Dependence; Hormones; Humans; Male; Methadone; Middle Aged; Naltrexone; Narcotic Antagonists; Narcotics; Octreotide; Pilot Projects; Substance Withdrawal Syndrome; Time Factors	1999
Naltrexone shortened opioid detoxification with buprenorphine. Drug and alcohol dependence, 1999, Oct-01, Volume: 56, Issue:3 Topics: Adult; Analgesics; Area Under Curve; Buprenorphine; Clonidine; Double-Blind Method; Drug Interactions; Drug Therapy, Combination; Female; Heroin; Heroin Dependence; Humans; Male; Naltrexone; Narcotic Antagonists; Substance Withdrawal Syndrome	1999
Plasma catecholamines during an ultrarapid heroin detoxification. Annals of the New York Academy of Sciences, 2000, Volume: 914 Topics: Adult; Analysis of Variance; Catecholamines; Drug Administration Routes; Drug Therapy, Combination; Female; Heroin; Heroin Dependence; Humans; Inactivation, Metabolic; Male; Naloxone; Naltrexone; Narcotic Antagonists; Substance Withdrawal Syndrome; Systole; Treatment Outcome	2000
Depot naltrexone: long-lasting antagonism of the effects of heroin in humans. Psychopharmacology, 2002, Volume: 159, Issue:4 Topics: Adult; Affect; Analysis of Variance; Chemistry, Pharmaceutical; Delayed-Action Preparations; Dose-Response Relationship, Drug; Heroin; Heroin Dependence; Humans; Injections, Intravenous; Male; Naltrexone; Narcotic Antagonists; Narcotics; Pupil	2002
Antagonist-precipitated heroin withdrawal under anaesthetic prior to maintenance naltrexone treatment: determinants of withdrawal severity. Drug and alcohol review, 2003, Volume: 22, Issue:4 Topics: Adolescent; Adult; Female; Heroin; Heroin Dependence; Humans; Male; Naltrexone; Narcotic Antagonists; Severity of Illness Index; Substance Withdrawal Syndrome; Surveys and Questionnaires	2003
Add-on gabapentin in the treatment of opiate withdrawal. Progress in neuro-psychopharmacology & biological psychiatry, 2004, Volume: 28, Issue:3 Topics: Acetates; Adult; Amines; Cyclohexanecarboxylic Acids; Excitatory Amino Acid Antagonists; Female; Gabapentin; gamma-Aminobutyric Acid; Heroin; Heroin Dependence; Humans; Male; Naltrexone; Narcotic Antagonists; Narcotics; Recurrence; Substance Withdrawal Syndrome	2004
Depot naltrexone: antagonism of the reinforcing, subjective, and physiological effects of heroin. Psychopharmacology, 2006, Volume: 189, Issue:1 Topics: Adult; Affect; Cardiovascular System; Choice Behavior; Delayed-Action Preparations; Dose-Response Relationship, Drug; Female; Heroin; Heroin Dependence; Humans; Liver; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Narcotics; Pupil; Self Administration; Time Factors; Token Economy	2006
Naltrexone with or without fluoxetine for preventing relapse to heroin addiction in St. Petersburg, Russia. Journal of substance abuse treatment, 2006, Volume: 31, Issue:4 Topics: Adult; Antidepressive Agents, Second-Generation; Combined Modality Therapy; Double-Blind Method; Drug Therapy, Combination; Female; Fluoxetine; Heroin; Heroin Dependence; HIV Infections; Humans; Male; Naltrexone; Narcotic Antagonists; Psychotherapy; Russia; Secondary Prevention; Substance Abuse, Intravenous; Substance Withdrawal Syndrome	2006
Predictors of induction onto extended-release naltrexone among unemployed heroin-dependent adults. Journal of substance abuse treatment, 2018, Volume: 85 Topics: Adult; Delayed-Action Preparations; Female; Heroin; Humans; Injections, Intramuscular; Male; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Substance Abuse Detection; Substance Abuse, Intravenous; Unemployment	2018
The effects of extended-release injectable naltrexone and incentives for opiate abstinence in heroin-dependent adults in a model therapeutic workplace: A randomized trial. Drug and alcohol dependence, 2019, 04-01, Volume: 197 Topics: Adult; Black or African American; Cocaine; Delayed-Action Preparations; Female; Heroin; Humans; Injections; Male; Middle Aged; Motivation; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Substance Abuse Detection; Workplace	2019

Other Studies

99 other study(ies) available for naltrexone and heroin

Article	Year
Naltrexone and behavior therapy for heroin addiction. NIDA research monograph, 1979, Issue:25 Topics: Adult; Behavior Therapy; California; Dose-Response Relationship, Drug; Ethnicity; Follow-Up Studies; Heroin; Heroin Dependence; Humans; Naloxone; Naltrexone	1979
Heroin and naltrexone effects on pituitary-gonadal hormones in man: tolerance and supersensitivity. NIDA research monograph, 1979, Volume: 27 Topics: Adult; Heroin; Heroin Dependence; Humans; Luteinizing Hormone; Male; Naloxone; Naltrexone; Prolactin; Testosterone	1979
The clinical usefulness of narcotic antagonists: implications of behavioral research. The American journal of drug and alcohol abuse, 1975, Volume: 2, Issue:3-4 Topics: Aftercare; Behavior Therapy; Conditioning, Operant; Cyclazocine; Extinction, Psychological; Heroin; Heroin Dependence; Hospitalization; Humans; Methadone; Naloxone; Naltrexone; Narcotic Antagonists; Patient Dropouts; Reinforcement, Psychology; Research Design; Self-Assessment	1975
Naltrexone: disposition, metabolism, and effects after acute and chronic dosing. Clinical pharmacology and therapeutics, 1976, Volume: 20, Issue:3 Topics: Adult; Drug Administration Schedule; Half-Life; Heroin; Humans; Kinetics; Male; Naloxone; Naltrexone; Pupil; Respiration; Time Factors	1976
Psychopathology and mood during heroin use: acute vs chronic effects. Archives of general psychiatry, 1976, Volume: 33, Issue:12 Topics: Acute Disease; Adult; Chronic Disease; Dose-Response Relationship, Drug; Drug Therapy, Combination; Emotions; Euphoria; Heroin; Heroin Dependence; Humans; Male; Methadone; Morphine; Motor Activity; Naloxone; Naltrexone; Psychopathology	1976
Naltrexone and clonidine in heroin withdrawal treatment. The British journal of psychiatry : the journal of mental science, 1989, Volume: 154 Topics: Clonidine; Heroin; Humans; Naltrexone; Substance Withdrawal Syndrome	1989
False positive urine drug screens from quinine in tonic water. Addictive behaviors, 1989, Volume: 14, Issue:2 Topics: Adult; Alcoholism; Heroin; Heroin Dependence; Humans; Male; Middle Aged; Mineral Waters; Naltrexone; Patient Compliance; Quinine	1989
Evidence for opioid mechanisms in the behavioral effects of nicotine. Psychopharmacology, 1988, Volume: 96, Issue:1 Topics: Animals; Behavior, Animal; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Interactions; Heroin; Male; Mecamylamine; Naltrexone; Nicotine; Rats; Rats, Inbred Strains; Receptors, Opioid	1988
The role of drugs in the treatment of opioid addicts. The Medical journal of Australia, 1986, Oct-20, Volume: 145, Issue:8 Topics: Alcoholism; Anxiety; Clonidine; Dextropropoxyphene; Heroin; Humans; Inactivation, Metabolic; Kinetics; Methadone; Mood Disorders; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders	1986
Blood pressure monitoring at home for rapid opioid withdrawal with clonidine and naltrexone. Lancet (London, England), 1987, Mar-14, Volume: 1, Issue:8533 Topics: Administration, Oral; Adult; Blood Pressure Determination; Clonidine; Drug Therapy, Combination; Female; Heroin; Home Nursing; Humans; Monitoring, Physiologic; Naltrexone; Substance Withdrawal Syndrome; Telephone	1987
Chronic naltrexone treatment increases the heroin-produced facilitation of self-stimulation. Pharmacology, biochemistry, and behavior, 1985, Volume: 22, Issue:2 Topics: Animals; Drug Synergism; Heroin; Male; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Self Stimulation; Time Factors	1985
Opiate withdrawal: inpatient versus outpatient programmes. British medical journal (Clinical research ed.), 1986, Aug-09, Volume: 293, Issue:6543 Topics: Clonidine; Heroin; Hospitalization; Humans; Naltrexone; Substance Withdrawal Syndrome	1986
Antagonist treatment in nucleus accumbens or periaqueductal grey affects heroin self-administration. Pharmacology, biochemistry, and behavior, 1988, Volume: 30, Issue:2 Topics: Animals; Cocaine; Heroin; Male; Microinjections; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Periaqueductal Gray; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Self Administration	1988
Clinical utility of rapid clonidine-naltrexone detoxification for opioid abusers. British journal of addiction, 1988, Volume: 83, Issue:5 Topics: Adult; Clinical Protocols; Clonidine; Drug Therapy, Combination; Female; Heroin; Humans; Male; Naltrexone; Substance-Related Disorders	1988
Heroin self-administration: effects of antagonist treatment in lateral hypothalamus. Pharmacology, biochemistry, and behavior, 1987, Volume: 27, Issue:4 Topics: Animals; Catheterization; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Interactions; Heroin; Hypothalamus; Male; Microinjections; Naltrexone; Quaternary Ammonium Compounds; Rats; Self Administration	1987
Clonidine and naltrexone in the outpatient treatment of heroin withdrawal. The American journal of drug and alcohol abuse, 1987, Volume: 13, Issue:1-2 Topics: Adult; Ambulatory Care; Clonidine; Drug Therapy, Combination; Female; Heroin; Humans; Male; Naltrexone; Substance Withdrawal Syndrome	1987
Effects of opiate antagonist treatment into either the periaqueductal grey or nucleus accumbens on heroin-induced locomotor activation. Brain research bulletin, 1987, Volume: 19, Issue:5 Topics: Animals; Heroin; Injections; Male; Motor Activity; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Periaqueductal Gray; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Septal Nuclei	1987
Effects of opioids and phencyclidine in combination with naltrexone on the acquisition and performance of response sequences in monkeys. Pharmacology, biochemistry, and behavior, 1985, Volume: 22, Issue:6 Topics: Animals; Cyclazocine; Dose-Response Relationship, Drug; Erythrocebus patas; Female; Heroin; Methadone; Naloxone; Naltrexone; Narcotics; Phencyclidine; Reinforcement Schedule; Serial Learning	1985
Heroin and cocaine intravenous self-administration in rats: mediation by separate neural systems. Psychopharmacology, 1982, Volume: 78, Issue:3 Topics: Animals; Cocaine; Conditioning, Operant; Dose-Response Relationship, Drug; Flupenthixol; Heroin; Infusions, Parenteral; Male; Motor Activity; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Opioid; Self Administration	1982
Evidence from opiate binding studies that heroin acts through its metabolites. Life sciences, 1983, Volume: 33 Suppl 1 Topics: Animals; Brain; Cell Membrane; Heroin; Male; Morphine; Morphine Derivatives; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Structure-Activity Relationship	1983
Effects of opiate antagonists and their quaternary derivatives on heroin self-administration in the rat. The Journal of pharmacology and experimental therapeutics, 1984, Volume: 229, Issue:2 Topics: Animals; Dose-Response Relationship, Drug; Heroin; Male; Naloxone; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Reinforcement, Psychology; Self Administration; Time Factors	1984
Effects of heroin and naltrexone on plasma prolactin levels in man. Pharmacology, biochemistry, and behavior, 1980, Volume: 12, Issue:1 Topics: Adult; Heroin; Heroin Dependence; Humans; Male; Naloxone; Naltrexone; Prolactin	1980
Heroin self-administration in rats under a progressive ratio schedule of reinforcement. Psychopharmacology, 1993, Volume: 111, Issue:2 Topics: Animals; Conditioning, Operant; Dose-Response Relationship, Drug; Food; Heroin; Male; Naltrexone; Rats; Rats, Wistar; Reinforcement Schedule; Self Administration	1993
Alkylation of mu opioid receptors by beta-funaltrexamine in vivo: comparison of the effects on in situ binding and heroin self-administration in rats. The Journal of pharmacology and experimental therapeutics, 1995, Volume: 272, Issue:3 Topics: Alkylation; Animals; Behavior, Animal; Binding, Competitive; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Heroin; In Vitro Techniques; Injections, Intraventricular; Naltrexone; Rats; Rats, Inbred F344; Receptors, Opioid, mu; Self Administration	1995
Supraspinal delta receptor subtype activity of heroin and 6-monoacetylmorphine in Swiss Webster mice. Life sciences, 1994, Volume: 55, Issue:8 Topics: Animals; Benzylidene Compounds; Heroin; Male; Mice; Morphine Derivatives; Naltrexone; Pain; Receptors, Opioid, delta	1994
Effects of opiates on blood rheology. Journal of toxicology. Clinical toxicology, 1994, Volume: 32, Issue:4 Topics: Adult; Cell Aggregation; Female; Fibrinogen; Hemorheology; Heroin; Heroin Dependence; Humans; Leukocytes; Male; Naltrexone; Prothrombin Time	1994
Effect of antagonists selective for mu, delta and kappa opioid receptors on the reinforcing effects of heroin in rats. The Journal of pharmacology and experimental therapeutics, 1993, Volume: 265, Issue:3 Topics: Animals; Heroin; Male; Naloxone; Naltrexone; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Self Administration	1993
Heroin withdrawal precipitated by nonmedical use of naltrexone. The American journal of psychiatry, 1993, Volume: 150, Issue:2 Topics: Adult; Heroin; Heroin Dependence; Humans; Male; Naltrexone; Self Medication; Substance Withdrawal Syndrome	1993
The effects of eticlopride and naltrexone on responding maintained by food, cocaine, heroin and cocaine/heroin combinations in rats. The Journal of pharmacology and experimental therapeutics, 1996, Volume: 277, Issue:3 Topics: Analysis of Variance; Animals; Cocaine; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Combinations; Eating; Heroin; Male; Naltrexone; Rats; Rats, Inbred F344; Receptors, Opioid; Salicylamides	1996
Within-session determination of dose-response curves for heroin self-administration in rats: Comparison with between-session determination and effects of naltrexone. Drug and alcohol dependence, 1996, Volume: 41, Issue:2 Topics: Animals; Dose-Response Relationship, Drug; Drug Administration Schedule; Heroin; Heroin Dependence; Male; Motivation; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred F344; Reinforcement Schedule; Self Administration	1996
Effects of opioid and dopamine receptor antagonists on relapse induced by stress and re-exposure to heroin in rats. Psychopharmacology, 1996, Volume: 125, Issue:4 Topics: Animals; Behavior, Animal; Dopamine; Dopamine Antagonists; Heroin; Male; Microdialysis; Motor Activity; Naltrexone; Narcotic Antagonists; Narcotics; Nucleus Accumbens; Raclopride; Rats; Salicylamides; Self Administration; Stress, Physiological	1996
Effects of chronic treatment with methadone and naltrexone on sleep in addicts. European archives of psychiatry and clinical neuroscience, 1996, Volume: 246, Issue:6 Topics: Adult; Analgesics, Opioid; Female; Heroin; Humans; Male; Methadone; Naltrexone; Narcotic Antagonists; Sleep; Substance-Related Disorders	1996
Potential danger of nalmefene use in the emergency department. Annals of emergency medicine, 1997, Volume: 29, Issue:1 Topics: Emergency Service, Hospital; Heroin; Humans; Naltrexone; Narcotic Antagonists; Patient Discharge; Substance Withdrawal Syndrome	1997
3-Methoxynaltrexone, a selective heroin/morphine-6beta-glucuronide antagonist. FEBS letters, 1997, Jul-21, Volume: 412, Issue:1 Topics: Analgesia; Animals; Binding Sites; Binding, Competitive; CHO Cells; Cricetinae; Heroin; Male; Mice; Morphine; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu; Transfection; Tritium	1997
Persistent analgesia in former opiate addicts is resistant to blockade of endogenous opioids. Biological psychiatry, 1997, Nov-15, Volume: 42, Issue:10 Topics: Adult; Analgesia; Drug Tolerance; Female; Heroin; Humans; Inactivation, Metabolic; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Pain Threshold; Perceptual Disorders; Receptors, Opioid; Substance-Related Disorders	1997
Ultrarapid opiate detoxification. What's all the fuss about? The Medical journal of Australia, 1997, Oct-06, Volume: 167, Issue:7 Topics: Heroin; Heroin Dependence; Humans; Inactivation, Metabolic; Naltrexone; Narcotic Antagonists	1997
Ultrarapid opiate detoxification. The Medical journal of Australia, 1997, Oct-06, Volume: 167, Issue:7 Topics: Heroin; Heroin Dependence; Humans; Inactivation, Metabolic; Naltrexone; Narcotic Antagonists	1997
Heroin addiction and naltrexone. Australian family physician, 1998, Volume: 27, Issue:5 Topics: Australia; Heroin; Humans; Naltrexone; Narcotic Antagonists; Patient Education as Topic; Substance Abuse, Intravenous; Treatment Outcome	1998
Training dose and session time as contextual determinants of heroin self-administration in rats. Pharmacology, biochemistry, and behavior, 1998, Volume: 60, Issue:2 Topics: Animals; Dose-Response Relationship, Drug; Heroin; Male; Naltrexone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Rats; Rats, Inbred F344; Self Administration; Time Factors	1998
Self-administration of cocaine-heroin combinations by rhesus monkeys: antagonism by naltrexone. The Journal of pharmacology and experimental therapeutics, 1998, Volume: 286, Issue:1 Topics: Animals; Cocaine; Dose-Response Relationship, Drug; Drug Combinations; Female; Heroin; Macaca mulatta; Male; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Receptors, Opioid, mu; Self Administration	1998
Effects of beta-funaltrexamine on dose-effect curves for heroin self-administration in rats: comparison with alteration of [3H]DAMGO binding to rat brain sections. Drug and alcohol dependence, 1998, Oct-01, Volume: 52, Issue:2 Topics: Analgesics, Opioid; Animals; Brain; Caudate Nucleus; Cocaine; Culture Techniques; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Heroin; Heroin Dependence; Motivation; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Radioligand Assay; Rats; Receptors, Opioid, mu; Self Administration	1998
Heroin antinociception changed from mu to delta receptor in streptozotocin-treated mice. Japanese journal of pharmacology, 1998, Volume: 78, Issue:4 Topics: Analgesics, Opioid; Animals; Anti-Bacterial Agents; Benzylidene Compounds; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Heroin; Injections, Intraventricular; Male; Mice; Morphine; Morphine Derivatives; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Pain; Receptors, Opioid, delta; Receptors, Opioid, mu; Streptozocin; Time Factors	1998
Antagonism of heroin and morphine self-administration in rats by the morphine-6beta-glucuronide antagonist 3-O-methylnaltrexone. European journal of pharmacology, 1999, Oct-27, Volume: 383, Issue:2 Topics: Animals; Conditioning, Operant; Dose-Response Relationship, Drug; Heroin; Injections, Subcutaneous; Male; Morphine; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Narcotics; Pain Measurement; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley; Rats, Wistar; Self Administration	1999
Heroin modulates the expression of inducible nitric oxide synthase. Immunopharmacology, 2000, Volume: 46, Issue:3 Topics: Animals; Gene Expression Regulation; Heroin; Lipopolysaccharides; Male; Naltrexone; Narcotics; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Rats; Rats, Inbred Lew	2000
Phenotypic and functional assessments of immune status in the rat spleen following acute heroin treatment. Immunopharmacology, 2000, Volume: 46, Issue:3 Topics: Animals; Concanavalin A; Dose-Response Relationship, Drug; Heroin; Immune System; Immunophenotyping; Interferon-gamma; Killer Cells, Natural; Lipopolysaccharides; Lymphocyte Activation; Male; Naltrexone; Narcotics; Rats; Rats, Inbred Lew; Spleen	2000
Morphine tolerance in mice changes response of heroin from mu to delta opioid receptors. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 2000, Volume: 224, Issue:2 Topics: Analgesics, Opioid; Animals; Drug Tolerance; Heroin; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Narcotics; Quaternary Ammonium Compounds; Receptors, Opioid, delta; Receptors, Opioid, mu	2000
Acute dependence on, but not tolerance to, heroin and morphine as measured by respiratory effects in rhesus monkeys. European journal of pharmacology, 2000, Jun-09, Volume: 398, Issue:1 Topics: Analgesics, Opioid; Animals; Carbon Dioxide; Dose-Response Relationship, Drug; Drug Tolerance; Heroin; Heroin Dependence; Macaca mulatta; Morphine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Respiration; Time Factors	2000
Heroin-induced alterations in leukocyte numbers and apoptosis in the rat spleen. Cellular immunology, 2000, Jun-15, Volume: 202, Issue:2 Topics: Animals; Annexin A5; Apoptosis; Cells, Cultured; DNA Fragmentation; Heroin; L-Lactate Dehydrogenase; Leukocyte Count; Leukocytes, Mononuclear; Male; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Inbred Lew; Spleen	2000
Cocaine-like discriminative stimulus effects of heroin in squirrel monkeys: role of active metabolites and opioid receptor mechanisms. Psychopharmacology, 2000, Volume: 150, Issue:2 Topics: Analgesics, Opioid; Animals; Cocaine; Discrimination Learning; Dopamine Uptake Inhibitors; Heroin; Male; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Saimiri	2000
Antagonism of delta(2)-opioid receptors by naltrindole-5'-isothiocyanate attenuates heroin self-administration but not antinociception in rats. The Journal of pharmacology and experimental therapeutics, 2000, Volume: 294, Issue:3 Topics: Analgesics, Opioid; Animals; Cocaine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Heroin; Injections, Intraventricular; Isothiocyanates; Male; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain Measurement; Rats; Rats, Inbred F344; Receptors, Opioid, delta; Reinforcement, Psychology; Self Administration	2000
Differential antagonism of endomorphin-1 and endomorphin-2 spinal antinociception by naloxonazine and 3-methoxynaltrexone. Brain research, 2000, Oct-20, Volume: 881, Issue:1 Topics: Analgesics, Opioid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Heroin; Injections, Spinal; Male; Mice; Naloxone; Naltrexone; Oligopeptides; Pain Measurement; Receptors, Opioid, mu	2000
Acute opioid withdrawal in the emergency department: inadvertent naltrexone abuse? Emergency medicine (Fremantle, W.A.), 2001, Volume: 13, Issue:3 Topics: Acute Disease; Adult; Colic; Emergency Medical Services; Female; Heroin; Heroin Dependence; Humans; Injections, Intravenous; Naltrexone; Narcotics; Substance Withdrawal Syndrome; Vomiting	2001
Discriminative stimulus effects of intravenous heroin and its metabolites in rhesus monkeys: opioid and dopaminergic mechanisms. The Journal of pharmacology and experimental therapeutics, 2001, Volume: 299, Issue:2 Topics: Animals; Discrimination, Psychological; Dopamine; Dopamine Agonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Generalization, Psychological; Heroin; Injections, Intravenous; Macaca mulatta; Male; Naltrexone; Narcotic Antagonists; Narcotics; Receptors, Dopamine; Receptors, Opioid	2001
Characterization of the discriminative stimulus effects of buprenorphine in pigeons. Psychopharmacology, 2002, Volume: 160, Issue:2 Topics: Animals; Buprenorphine; Columbidae; Discrimination, Psychological; Dose-Response Relationship, Drug; Drug Tolerance; Heroin; Injections; Naltrexone; Narcotic Antagonists; Narcotics; Time Factors	2002
Differential involvement of mu-opioid receptors in the rostral versus caudal nucleus accumbens in the reinforcing effects of heroin in rats: evidence from focal injections of beta-funaltrexamine. Psychopharmacology, 2002, Volume: 161, Issue:2 Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Heroin; Injections, Intraventricular; Male; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Rats; Rats, Inbred F344; Receptors, Opioid, mu; Reinforcement, Psychology; Self Administration	2002
Antagonism of the antinociceptive and discriminative stimulus effects of heroin and morphine by 3-methoxynaltrexone and naltrexone in rhesus monkeys. The Journal of pharmacology and experimental therapeutics, 2002, Volume: 302, Issue:1 Topics: Analgesics; Analgesics, Opioid; Animals; Cues; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Heroin; Hot Temperature; Kinetics; Macaca mulatta; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain Measurement; Substance-Related Disorders	2002
Serum naltrexone and 6-beta-naltrexol levels from naltrexone implants can block very large amounts of heroin: a report of two cases. Addiction biology, 2002, Volume: 7, Issue:3 Topics: Adult; Delayed-Action Preparations; Dose-Response Relationship, Drug; Drug Implants; Half-Life; Heroin; Heroin Dependence; Humans; Male; Morphine; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Patient Dropouts	2002
Augmented production of proinflammatory cytokines and accelerated allotransplantation reactions in heroin-treated mice. Clinical and experimental immunology, 2003, Volume: 132, Issue:1 Topics: Animals; Cells, Cultured; Cytokines; Female; Fibrosarcoma; Heroin; Interferon-gamma; Interleukin-1; Interleukin-10; Interleukin-12; Interleukin-2; Interleukin-4; Macrophages, Peritoneal; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Naltrexone; Narcotic Antagonists; Narcotics; Neoplasms, Experimental; Nitric Oxide; Skin Transplantation; Spleen; Transplantation Immunology; Transplantation, Homologous	2003
Effects of heroin and its metabolites on schedule-controlled responding and thermal nociception in rhesus monkeys: sensitivity to antagonism by quadazocine, naltrindole and beta-funaltrexamine. Drug and alcohol dependence, 2003, May-01, Volume: 70, Issue:1 Topics: Animals; Azocines; Behavior, Animal; Dose-Response Relationship, Drug; Food; Heroin; Hot Temperature; Macaca mulatta; Morphine; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Pain Measurement	2003
Naltrexone implants can completely prevent early (1-month) relapse after opiate detoxification: a pilot study of two cohorts totalling 101 patients with a note on naltrexone blood levels. Addiction biology, 2003, Volume: 8, Issue:2 Topics: Adult; Cohort Studies; Drug Administration Routes; Female; Follow-Up Studies; Heroin; Heroin Dependence; Humans; Inactivation, Metabolic; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Pilot Projects; Prevalence; Prostheses and Implants; Recurrence	2003
Blood morphine levels in naltrexone-exposed compared to non-naltrexone-exposed fatal heroin overdoses. Addiction biology, 2003, Volume: 8, Issue:3 Topics: Adult; Australia; Cohort Studies; Drug Overdose; Female; Heroin; Heroin Dependence; Humans; Male; Morphine; Naltrexone; Narcotic Antagonists; Registries; Retrospective Studies; Time Factors	2003
Opioid partial agonist effects of 3-O-methylnaltrexone in rhesus monkeys. The Journal of pharmacology and experimental therapeutics, 2004, Volume: 308, Issue:3 Topics: Adenylyl Cyclases; Animals; Cocaine; Discrimination Learning; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Heroin; Heroin Dependence; Macaca mulatta; Male; Morphine; Morphine Derivatives; Naltrexone; Narcotics; Quaternary Ammonium Compounds; Receptors, Opioid, mu; Self Administration	2004
Orthoptic status before and immediately after heroin detoxification. The British journal of ophthalmology, 2004, Volume: 88, Issue:9 Topics: Accommodation, Ocular; Adolescent; Adult; Convergence, Ocular; Diplopia; Eye Movements; Heroin; Heroin Dependence; Humans; Methadone; Naltrexone; Narcotics; Refractive Errors; Vision, Binocular; Visual Acuity	2004
Convergent effects on cell signaling mechanisms mediate the actions of different neurobehavioral teratogens: alterations in cholinergic regulation of protein kinase C in chick and avian models. Annals of the New York Academy of Sciences, 2004, Volume: 1025 Topics: Animals; Cholinergic Fibers; Ducks; Female; Heroin; Imprinting, Psychological; Mice; Naltrexone; Pregnancy; Prenatal Exposure Delayed Effects; Signal Transduction; Teratogens	2004
Involvement of mu-, delta- and kappa-opioid receptor subtypes in the discriminative-stimulus effects of delta-9-tetrahydrocannabinol (THC) in rats. Psychopharmacology, 2005, Volume: 179, Issue:4 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Benzamides; Conditioning, Operant; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Food; Hallucinogens; Heroin; Male; Naltrexone; Narcotic Antagonists; Narcotics; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reinforcement, Psychology	2005
Effect of repeated administrations of heroin, naltrexone, methadone, and alcohol on morphine glucuronidation in the rat. Psychopharmacology, 2005, Volume: 182, Issue:1 Topics: Animals; Ethanol; Heroin; Heroin Dependence; Male; Methadone; Microsomes, Liver; Morphine; Morphine Derivatives; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu	2005
Motivational control of heroin seeking by conditioned stimuli associated with withdrawal and heroin taking by rats. Behavioral neuroscience, 2006, Volume: 120, Issue:1 Topics: Animals; Conditioning, Psychological; Food Preferences; Heroin; Male; Motivation; Naltrexone; Narcotic Antagonists; Rats; Substance Withdrawal Syndrome; Sucrose; Time Factors	2006
Does naltrexone affect craving in abstinent opioid-dependent patients? Addiction biology, 2007, Volume: 12, Issue:2 Topics: Adult; Female; Heroin; Heroin Dependence; Humans; Longitudinal Studies; Male; Methadone; Middle Aged; Motivation; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Secondary Prevention; Substance Abuse Detection; Substance Withdrawal Syndrome; Surveys and Questionnaires	2007
Micro-opioid receptor alkylation in the ventral pallidum and ventral tegmental area, but not in the nucleus accumbens, attenuates the effects of heroin on cocaine self-administration in rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2008, Volume: 33, Issue:5 Topics: Alkylating Agents; Alkylation; Analysis of Variance; Animals; Behavior, Animal; Cocaine; Conditioning, Operant; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Synergism; Globus Pallidus; Heroin; Male; Naltrexone; Narcotics; Nucleus Accumbens; Rats; Rats, Inbred F344; Receptors, Opioid, mu; Self Administration; Ventral Tegmental Area	2008
Opioid overdose deaths can occur in patients with naltrexone implants. The Medical journal of Australia, 2007, Jul-02, Volume: 187, Issue:1 Topics: Analgesics, Opioid; Drug Implants; Drug Overdose; Heroin; Humans; Naltrexone; Narcotic Antagonists; Substance-Related Disorders	2007
Interactions between Delta(9)-tetrahydrocannabinol and mu opioid receptor agonists in rhesus monkeys: discrimination and antinociception. Psychopharmacology, 2008, Volume: 199, Issue:2 Topics: Analgesics; Analgesics, Opioid; Animals; Data Interpretation, Statistical; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Female; Heroin; Hot Temperature; Hypnotics and Sedatives; Macaca mulatta; Male; Midazolam; Morphine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Pain Measurement; Receptors, Opioid, mu; Substance Withdrawal Syndrome	2008
Non-opioid induction of morphine-6-glucuronide synthesis is elicited by prolonged exposure of rat hepatocytes to heroin. Drug and alcohol dependence, 2008, Dec-01, Volume: 98, Issue:3 Topics: Analgesics, Opioid; Animals; Cell Separation; Cells, Cultured; Chromatography, High Pressure Liquid; Half-Life; Hepatocytes; Heroin; In Vitro Techniques; Male; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley	2008
In vivo chronic exposure to heroin or naltrexone selectively inhibits liver microsome formation of estradiol-3-glucuronide in the rat. Biochemical pharmacology, 2008, Sep-01, Volume: 76, Issue:5 Topics: Animals; Chromatography, High Pressure Liquid; Estradiol; Glucuronosyltransferase; Heroin; Male; Microsomes, Liver; Naltrexone; Narcotic Antagonists; Narcotics; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; Spectrometry, Fluorescence	2008
Effects of training and withdrawal periods on heroin seeking induced by conditioned cue in an animal of model of relapse. Psychopharmacology, 2009, Volume: 203, Issue:4 Topics: Animals; Behavior, Addictive; Behavior, Animal; Conditioning, Operant; Cues; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Exploratory Behavior; Heroin; Heroin Dependence; Male; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Secondary Prevention; Self Administration; Substance Withdrawal Syndrome	2009
Intravenous self-administration of etonitazene alone and combined with cocaine in rhesus monkeys: comparison with heroin and antagonism by naltrexone and naloxonazine. Psychopharmacology, 2009, Volume: 204, Issue:3 Topics: Animals; Benzimidazoles; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Drug Interactions; Female; Heroin; Injections, Intravenous; Macaca mulatta; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Receptors, Opioid, mu; Reinforcement, Psychology; Self Administration; Substance Abuse, Intravenous	2009
Involvement of exon 11-associated variants of the mu opioid receptor MOR-1 in heroin, but not morphine, actions. Proceedings of the National Academy of Sciences of the United States of America, 2009, Mar-24, Volume: 106, Issue:12 Topics: Alternative Splicing; Analgesia; Animals; Exons; Gastrointestinal Transit; Gene Targeting; Heroin; Heterozygote; Mice; Mice, Knockout; Morphine; Mutation; Naloxone; Naltrexone; Receptors, Opioid, mu	2009
Route of administration influences substitution patterns in rats trained to discriminate methadone vs. vehicle. Drug and alcohol dependence, 2009, Aug-01, Volume: 103, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Choice Behavior; Conditioning, Operant; Discrimination, Psychological; Heroin; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Methadone; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Pharmaceutical Vehicles; Rats; Rats, Sprague-Dawley; Stereoisomerism	2009
Involvement of the lateral amygdala in the antiallodynic and reinforcing effects of heroin in rats after peripheral nerve injury. Anesthesiology, 2011, Volume: 114, Issue:3 Topics: Amygdala; Analgesics, Opioid; Animals; Behavior, Animal; Brain; Conditioning, Operant; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Guanosine 5'-O-(3-Thiotriphosphate); Heroin; Hyperalgesia; Infusions, Intravenous; Male; Naltrexone; Narcotic Antagonists; Peripheral Nerve Injuries; Rats; Rats, Inbred F344; Reinforcement, Psychology; Self Administration; Spinal Nerves	2011
Determining the clinically important difference in visual analog scale scores in abuse liability studies evaluating novel opioid formulations. Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2012, Volume: 21, Issue:6 Topics: Analgesics, Opioid; Heroin; Humans; Naltrexone; Opioid-Related Disorders	2012
Effect of chronic delivery of the Toll-like receptor 4 antagonist (+)-naltrexone on incubation of heroin craving. Biological psychiatry, 2013, Apr-15, Volume: 73, Issue:8 Topics: Animals; Behavior, Addictive; Conditioning, Operant; Cues; Dose-Response Relationship, Drug; Drug Administration Schedule; Extinction, Psychological; Heroin; Infusion Pumps, Implantable; Methamphetamine; Naltrexone; Narcotic Antagonists; Rats; Self Administration; Stereoisomerism; Time Factors; Toll-Like Receptor 4	2013
Paediatric palliative care: intravenous methylnaltrexone relieves constipation. BMJ supportive & palliative care, 2013, Volume: 3, Issue:1 Topics: Administration, Intravenous; Analgesics, Opioid; Child, Preschool; Constipation; Heroin; Humans; Male; Naltrexone; Narcotic Antagonists; Palliative Care; Quaternary Ammonium Compounds	2013
3-Methoxynaltrexone is not a selective antagonist for the acute psychomotor stimulating effects of heroin and 6-monoacetylmorphine in mice. Pharmacology, biochemistry, and behavior, 2014, Volume: 122 Topics: Animals; Dose-Response Relationship, Drug; Heroin; Male; Mice; Mice, Inbred C57BL; Morphine Derivatives; Motor Activity; Naltrexone; Narcotic Antagonists; Psychomotor Performance; Time Factors	2014
A role for kappa-, but not mu-opioid, receptor activation in acute food deprivation-induced reinstatement of heroin seeking in rats. Addiction biology, 2015, Volume: 20, Issue:3 Topics: Animals; Conditioning, Operant; Drug-Seeking Behavior; Extinction, Psychological; Food Deprivation; Heroin; Male; Naltrexone; Narcotic Antagonists; Narcotics; Rats, Long-Evans; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recurrence; Self Administration; Stress, Psychological	2015
The effectiveness of opioid substitution treatments for patients with opioid dependence: a systematic review and multiple treatment comparison protocol. Systematic reviews, 2014, Sep-19, Volume: 3 Topics: Buprenorphine; Buprenorphine, Naloxone Drug Combination; Heroin; Humans; Methadone; Naloxone; Naltrexone; Narcotics; Opiate Substitution Treatment; Opioid-Related Disorders; Research Design; Systematic Reviews as Topic	2014
Development and validation of a bioanalytical method for the simultaneous determination of heroin, its main metabolites, naloxone and naltrexone by LC-MS/MS in human plasma samples: Application to a clinical trial of oral administration of a heroin/naloxo Journal of pharmaceutical and biomedical analysis, 2015, Oct-10, Volume: 114 Topics: Administration, Oral; Calibration; Chromatography, Liquid; Codeine; Formates; Healthy Volunteers; Heroin; Humans; Hydrogen-Ion Concentration; Limit of Detection; Morphine; Naloxone; Naltrexone; Quality Control; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Substance Abuse Detection; Tandem Mass Spectrometry	2015
Alterations of naltrexone-induced conditioned place avoidance by pre-exposure to high fructose corn syrup or heroin in Sprague-Dawley rats. Psychopharmacology, 2016, Volume: 233, Issue:3 Topics: Animals; Avoidance Learning; Conditioning, Operant; Dose-Response Relationship, Drug; Food Deprivation; Heroin; High Fructose Corn Syrup; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome	2016
Kappa opioid receptor antagonism and chronic antidepressant treatment have beneficial activities on social interactions and grooming deficits during heroin abstinence. Addiction biology, 2017, Volume: 22, Issue:4 Topics: Animals; Antidepressive Agents, Second-Generation; Behavior, Animal; Disease Models, Animal; Fluoxetine; Grooming; Heroin; Heroin Dependence; Male; Mice; Mice, Inbred C57BL; Naltrexone; Narcotic Antagonists; Receptors, Opioid, kappa; Social Behavior; Time; Treatment Outcome	2017
Acceptability of Extended-Release Naltrexone by Heroin-Dependent Patients and Addiction Treatment Providers in the Netherlands. Substance use & misuse, 2016, 12-05, Volume: 51, Issue:14 Topics: Heroin; Heroin Dependence; Humans; Naltrexone; Netherlands	2016
Pharmacological classification of centrally acting drugs using EEG in freely moving rats: an old tool to identify new atypical dopamine uptake inhibitors. Neuropharmacology, 2019, 12-15, Volume: 161 Topics: Animals; Central Nervous System Agents; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Discovery; Electroencephalography; Heroin; Ketamine; Male; Methylphenidate; Modafinil; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu	2019
Investigation of the reinforcing potential of samidorphan and naltrexone by fixed and progressive ratio intravenous self-administration testing in heroin-maintained rats. Journal of psychopharmacology (Oxford, England), 2019, Volume: 33, Issue:3 Topics: Administration, Intravenous; Animals; Dose-Response Relationship, Drug; Heroin; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Reinforcement Schedule; Reinforcement, Psychology; Self Administration	2019
A further assessment of a role for Toll-like receptor 4 in the reinforcing and reinstating effects of opioids. Behavioural pharmacology, 2020, Volume: 31, Issue:2&3 Topics: Analgesics, Opioid; Animals; Conditioning, Operant; Heroin; Male; Naloxone; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Self Administration; Toll-Like Receptor 4	2020
Effectiveness and selectivity of a heroin conjugate vaccine to attenuate heroin, 6-acetylmorphine, and morphine antinociception in rats: Comparison with naltrexone. Drug and alcohol dependence, 2019, 11-01, Volume: 204 Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Administration Routes; Female; Fentanyl; Heroin; Male; Morphine; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Rats; Tetanus Toxoid; Vaccination	2019
Modulation of object memory consolidation by heroin and heroin-conditioned stimuli: Role of opioid and noradrenergic systems. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2020, Volume: 33 Topics: Adrenergic beta-Antagonists; Animals; Conditioning, Operant; Heroin; Male; Memory Consolidation; Naltrexone; Narcotic Antagonists; Narcotics; Norepinephrine; Pain Measurement; Propranolol; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic; Receptors, Opioid; Recognition, Psychology	2020
Evaluation of a Dual Fentanyl/Heroin Vaccine on the Antinociceptive and Reinforcing Effects of a Fentanyl/Heroin Mixture in Male and Female Rats. ACS chemical neuroscience, 2020, 05-06, Volume: 11, Issue:9 Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Female; Fentanyl; Heroin; Male; Naltrexone; Rats; Vaccines	2020
Systematic Structure-Based Virtual Screening Approach to Antibody Selection and Design of a Humanized Antibody against Multiple Addictive Opioids without Affecting Treatment Agents Naloxone and Naltrexone. ACS chemical neuroscience, 2021, 01-06, Volume: 12, Issue:1 Topics: Analgesics, Opioid; Heroin; Morphine; Naloxone; Naltrexone	2021
Discriminative stimulus effects of carfentanil in rats discriminating fentanyl: Differential antagonism by naltrexone. Drug and alcohol dependence, 2021, 04-01, Volume: 221 Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Fentanyl; Heroin; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu	2021
Opioid Use Disorder Among Clients of Community Mental Health Clinics: Prevalence, Characteristics, and Treatment Willingness. Psychiatric services (Washington, D.C.), 2022, Mar-01, Volume: 73, Issue:3 Topics: Adult; Analgesics, Opioid; Buprenorphine; Female; Heroin; Humans; Male; Mental Health; Naltrexone; Opioid-Related Disorders; Prevalence	2022
Patient characteristics associated with initiation of XR-naltrexone for opioid use disorder in clinical trials. Drug and alcohol dependence, 2022, 04-01, Volume: 233 Topics: Analgesics, Opioid; Delayed-Action Preparations; Heroin; Humans; Injections, Intramuscular; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Substance Withdrawal Syndrome	2022
Functional consequences of short-term exposure to opioids versus cannabinoids in nonhuman primates. Neuropharmacology, 2023, Feb-01, Volume: 223 Topics: Analgesics, Opioid; Animals; Cannabinoid Receptor Agonists; Cannabinoids; Dose-Response Relationship, Drug; Dronabinol; Female; Heroin; Male; Morphine; Naltrexone; Rimonabant	2023