naltrexone has been researched along with enkephalin, methionine in 161 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 42 (26.09) | 18.7374 |
| 1990's | 52 (32.30) | 18.2507 |
| 2000's | 44 (27.33) | 29.6817 |
| 2010's | 22 (13.66) | 24.3611 |
| 2020's | 1 (0.62) | 2.80 |
| Authors | Studies |
|---|---|
| Di Giulio, AM; Donadoni, ML; Finco, C; Germani, E; Gorio, A; Malosio, ML; Mantegazza, P; Tenconi, B | 1 |
| McLaughlin, PJ; Zagon, IS | 7 |
| Akami, T; Arakawa, K; Matsumoto, S; Mitsuo, M; Nagase, H; Nakai, I; Nakajima, H; Oka, T; Okamoto, M | 1 |
| Bourgoin, S; Cesselin, F; Collin, E; Ferhat, L; Hamon, M | 1 |
| Bodnar, RJ; Kest, B; Orlowski, M | 1 |
| Bakich, V; Law, S; McIntosh, CH | 1 |
| Ghanta, VK; Hiramoto, RN; Hsueh, CM | 1 |
| Bourgoin, S; Cesselin, F; Collin, E; Hamon, M; Mantelet, S | 1 |
| Isayama, T; McLaughlin, PJ; Zagon, IS | 1 |
| Barnes, MI; Hong, JS; Hudson, PM; Mitchell, CL | 1 |
| Ghanta, VK; Hiramoto, NS; Hiramoto, RN; Hsueh, CM; Rogers, CF; Soong, SJ | 1 |
| Gienapp, IE; Gudehithlu, KP; Hanissian, SH; Malarkey, WB; Tejwani, GA; Whitacre, CC | 1 |
| Cone, EJ; Johnson, RE; Su, TP; Vaupel, DB | 1 |
| Lee, SY; Rhee, HM | 1 |
| Costa, E; Mocchetti, I; Ritter, A | 1 |
| Dousa, MK; Gaumann, DM; Tyce, GM; Yaksh, TL | 1 |
| Heyman, JS; Jiang, Q; Mosberg, HI; Porreca, F; Rothman, RB | 1 |
| Gentle, MJ; Savory, CJ; Yeomans, MR | 1 |
| Dahlin, I; Fredholm, BB; Lagercrantz, H; Moss, IR; Nyberg, F; Runold, M | 1 |
| Carino, MA; Horita, A; Yamawaki, S | 1 |
| Herz, A; Millan, MH; Millan, MJ; Reid, LD | 1 |
| Fitzgerald, RD; Harris, GC | 1 |
| Baratti, CM; Introini, IB; McGaugh, JL | 1 |
| Fries, DS; Larson, DL; Portoghese, PS; Takemori, AE; Ward, SJ | 1 |
| Portoghese, PS; Takemori, AE | 2 |
| Gioannini, T; Hui, KS; Hui, M; Lajtha, A; Simon, EJ | 1 |
| Laubie, M; Schmitt, H | 1 |
| Coscia, CJ; Devane, WA; Howlett, AC; Spain, JW | 1 |
| Zagon, IS | 1 |
| Haddad, GG; Jeng, HJ; Lai, TL | 1 |
| Abhold, R; Kalivas, PW | 1 |
| Elsworth, JD; Redmond, DE; Roth, RH | 1 |
| Frenk, H; Kaufman, EF; Kinscheck, IB; Mayer, DJ; Miller, J; Watkins, LR | 1 |
| Buéno, L; Fargeas, MJ; Fioramonti, J | 1 |
| Asdourian, D; Geula, C | 1 |
| del Río, J; Fernández-Tomé, MP; González, Y; Sánchez-Franco, F | 1 |
| North, RA; Williams, JT | 1 |
| Gardner, EL; Tempel, A; Zukin, RS | 2 |
| Bajusz, S; Berzétei, IP; Rónai, AZ; Székely, JI | 1 |
| Ho, AK; Rossi, N | 1 |
| Herz, A; Millan, MH; Millan, MJ; Przewłocki, R | 1 |
| Bajorek, JG; Lee, RJ; Lomax, P | 1 |
| Carrasco, MA; Dias, RD; Elisabetsky, E; Izquierdo, I; Perry, ML; Souza, DO | 1 |
| Byrne, WL; Codd, EE | 1 |
| Blume, AJ; Fantozzi, R; Mullikin-Kilpatrick, D | 1 |
| Clark, WG | 1 |
| De Souza, EB; Van Loon, GR | 1 |
| Cools, AR; Megens, AA | 1 |
| Blume, AJ; Larsen, NE; Mullikin-Kilpatrick, D | 1 |
| Bohus, B; De Wied, D; Drago, F; Fekete, M; Van Ree, JM; Wiegant, VM | 1 |
| Kameyama, T; Ukai, M | 1 |
| Frenk, H; Mayer, DJ; Miller, J; Watkins, LR | 1 |
| Levine, AS; Morley, JE; Silvis, SE | 1 |
| Kamerling, SG; Martin, WR; Sloan, JW; Su, TP; Wettstein, JG | 1 |
| Collins, KA; Portoghese, PS; Tsai, JH; Tseng, LF | 1 |
| Armstead, WM | 2 |
| Shahabi, NA; Sharp, BM | 1 |
| McLaughlin, PJ; Sassani, JW; Zagon, IS | 3 |
| Angel, F; Baumann, R; Chamouard, P; Meyer, C; Rohr, S | 1 |
| Lee, YS; Wurster, RD | 1 |
| Nishiyama, N; Schwartz, JP; Taniwaki, T; Wilson, D | 1 |
| Benoliel, JJ; Bourgoin, S; Cesselin, F; Collin, E; Hamon, M; Mauborgne, A | 1 |
| Iwamoto, Y; Kamei, J; Kasuya, Y; Misawa, M; Nagase, H | 1 |
| Carr, JA; Saland, LC; Samora, A; Tejeda, D | 1 |
| Kawabata, A; Takagi, H; Umeda, N | 1 |
| Magyar, A; Medzihradszky, K; Rónai, AZ | 1 |
| Ordög, T; Vértes, M; Vértes, Z | 1 |
| McLaughlin, PJ; Wu, Y; Zagon, IS | 4 |
| Bobek, S; Niezgoda, J; Pierzchała-Koziec, K; Przewłocki, R | 1 |
| Casares, F; Liu, U; Stefano, GB | 1 |
| Kolta, MG; Ngong, JM; Pierzchala, K; Rutledge, LP; Van Loon, GR | 1 |
| Goldstein, BD; Zachariou, V | 1 |
| Chen, SF; Ghanta, VK; Hiramoto, RN; Hsueh, CM; Huang, HJ | 1 |
| Kane, ER; McLaughlin, PJ; Sassani, JW; Zagon, IS | 1 |
| Mizoguchi, H; Nagase, H; Narita, M; Tseng, LF | 1 |
| Kragballe, K; Nissen, JB | 1 |
| Adams, DJ; Trequattrini, C | 1 |
| Andoh, T; Ito, H; Kamiya, Y; Oka, K; Watanabe, I | 1 |
| Foxx-Orenstein, AE; Grider, JR; Jin, JG | 1 |
| Fan, XT; Kitamura, K; Oka, T; Taniguchi, T | 1 |
| Benyhe, S; Borsodi, A; Medzihradszky, K; Orosz, G; Rónai, AZ; Sartania, N; Szatmári, I | 1 |
| Chu, XP; Li, P; Wang, JQ; Xu, NS | 1 |
| Allescher, HD; Brechmann, C; Hahn, A; Schusdziarra, V; Storr, M | 1 |
| Bonneau, RH; Lang, CM; McLaughlin, PJ; Zagon, IS; Zalys, R | 1 |
| Lang, CM; McLaughlin, PJ; Wilson, RP; Zagon, IS | 1 |
| Ballet, S; Cesselin, F; Collin, E; Hamon, M; Mauborgne, A | 1 |
| Cheong, YP; Cho, KP; Kim, CJ; Kim, JK; Kim, KW; Kwun, J; Woo, RS | 1 |
| Dimitrijević, M; Kovacević-Jovanović, V; Miletić, T; Radulović, J; Stanojević, S; Vujić-Redzić, V | 1 |
| Levin, RJ; McLaughlin, PJ; Ohlsson-Wilhelm, BM; Roesener, CD; Verderame, MF; Zagon, IS | 1 |
| Bilfinger, TV; Magazine, HI; Murga, JD; Qi, F; Saeed, RW; Short, TW; Stefano, GB | 1 |
| Bhandari, RN; Clarke, RW; Leggett, J | 1 |
| Fujimura, T; Hayashi, T; Kastin, AJ; Murayama, K; Narita, M; Orito, T; Sakurada, C; Sakurada, S; Sakurada, T; Suzuki, T; Tan-no, K; Tseng, LF; Yuhki, M; Zadina, JE | 1 |
| Bourgoin, S; Cesselin, F; Mauborgne, A; Poliénor, H; Roumy, M; Simonnet, G; Zajac, JM | 1 |
| Commons, KG; Kow, LM; Ogawa, S; Pfaff, DW | 1 |
| Dimitrijević, M; Kovacević-Jovanović, V; Radulović, J; Stanojević, S; Vujić, V | 1 |
| Fry, JL; Jenkins, JB; Lang, CM; McLaughlin, PJ; Ruth, TB; Sassani, JW; Wylie, JD; Zagon, IS | 1 |
| Caffrey, JL; Farias, M; Jackson, KE; Yoshishige, D | 1 |
| Davis, BJ; Li, CS; Smith, DV | 1 |
| Qian, X; Soong, Y; Szeto, HH; Wu, D; Zhao, GM | 1 |
| Atnip, RG; Essis, FM; Healy, DA; McLaughlin, PJ; Verderame, MF; Zagon, IS | 1 |
| Bujdosó, E; Farkas, J; Jászberényi, M; Telegdy, G; Tóth, G; Wollemann, M | 1 |
| Cao, Z; Liu, L; Van Winkle, DM | 1 |
| Blisnick, T; Desor, D; Dugave, C; Hermitte, V; Messaoudi, M; Rigault, AG; Rougeon, F; Rougeot, C | 1 |
| Barrington, PL; Ellenberger, EA; Lucas, HL; Mueller, JL; Quock, RM; Russo, JM; Tseng, LF | 1 |
| Eriksson, PS; Jonsdottir, IH; Naylor, AS; Nyberg, F; Persson, AI; Thorlin, T | 1 |
| Berry, JA; Bolling, SF; McNish, RA; Romano, MA; Seymour, EM | 1 |
| Cox, ML; Welch, SP | 1 |
| McLaughlin, PJ; Ruth, TB; Zagon, IS | 1 |
| Hochol, A; Malendowicz, LK; Nussdorfer, GG; Rebuffat, P; Tortorella, C; Ziolkowska, A | 1 |
| Barlow, MA; Caffrey, JL; Deo, S; Johnson, S | 1 |
| Bouvier, M; Breit, A; Devi, LA; Gagnidze, K; Lagacé, M | 1 |
| Barlow, MA; Caffrey, JL; Deo, SH; Johnson-Davis, S; Yoshishige, D | 1 |
| Barlow, M; Caffrey, JL; Davis, S; Deo, SH; Farias, M; Yoshishige, D | 1 |
| Lu, ZH; Wang, Q; Xiong, LZ; Yang, J | 1 |
| McLaughlin, PJ; Rahn, KA; Zagon, IS | 2 |
| Fossum, EN; Ingram, SL; Macey, TA; Morgan, MM | 1 |
| Dolt, KS; Karar, J; Kumar, K; Mohan, A; Nath, M; Pasha, MA; Pasha, S; Vats, ID | 1 |
| Dimitrijević, M; Kovacević-Jovanović, V; Kustrimović, N; Miletić, T; Mitić, K; Stanojević, S; Vujić, V | 1 |
| Devidze, N; Kow, LM; Lee, AW; Pataky, S; Pfaff, DW; Zhang, Q; Zhou, J | 1 |
| Chung, E; Ohgami, Y; Quock, RM; Shirachi, DY; Zelinski, LM | 1 |
| Donahue, RN; McLaughlin, PJ; Zagon, IS | 3 |
| Arttamangkul, S; Birdsong, WT; Virk, MS; Williams, JT | 1 |
| Carroll, MA; McLaughlin, PJ; Sassani, JW; Zagon, IS | 1 |
| Cleary, DR; Fyfe, LW; Ingram, SL; Macey, TA; Morgan, MM | 1 |
| Bonneau, RH; Donahue, RN; McLaughlin, PJ; Zagon, IS | 1 |
| Henriksen, EJ; Ibrahim, MM; Mata, HP; Philip Malan, T; Porreca, F; Stagg, NJ; Vanderah, TW | 1 |
| Bagosi, Z; Csabafi, K; Jászberényi, M; Telegdy, G; Tóth, G; Wollemann, M | 1 |
| Goyal, R; Kumar, K; Mohan, A; Mudgal, A; Pasha, S | 1 |
| Heeman, JH; Quock, RM; Shirachi, DY; Zhang, Y | 1 |
| Jiang, S; Liu, Z; Song, L; Wang, L; Wang, W; Zhang, R; Zhou, Z | 1 |
| Hammer, LA; McLaughlin, PJ; Waldner, H; Zagon, IS | 1 |
| Barlow, MA; Caffrey, JL; Downey, HF; Estrada, JA; Mallet, RT; Williams, AG; Yoshishige, D | 1 |
| Hiramoto, K; Yamate, Y; Yokoyama, S | 1 |
| Aira, Z; Azkue, JJ; Buesa, I; Medrano, MC; Mendiguren, A; Pablos, P; Pineda, J; Santamarta, MT | 1 |
| Ludwig, MD; McLaughlin, PJ; Zagon, IS | 2 |
| Gao, XH; Griffin, N; Jiao, X; Plotnikoff, NP; Qi, RQ; Shan, FP; Wang, DM | 1 |
| Baamonde, A; Cernuda-Cernuda, R; Fernández-García, MT; Folgueras, AR; García-Domínguez, M; Hidalgo, A; Lastra, A; Menéndez, L | 1 |
| Barrouin-Melo, SM; Borges, NF; D'Assis, MJMH; da Costa-Neto, JM; Estrela-Lima, A; Machado, MC; Martins-Filho, OA; Portela, RD; Silva, FL | 1 |
| Hamamura, K; Kondo, H; Tanaka, K; Togari, A | 1 |
| Shan, F; Wang, R; Zhang, Y | 1 |
| McLaughlin, PJ; Purushothaman, I; Sassani, JW; Zagon, IS | 1 |
| Bell, GI; Chen, Y; Kong, H; Raynor, K; Reisine, T; Yasuda, K; Yu, L | 1 |
| Bell, GI; Breder, CD; Kong, H; Raynor, K; Reisine, T; Takeda, J; Yasuda, K | 1 |
4 review(s) available for naltrexone and enkephalin, methionine
| Article | Year |
|---|---|
[Enkephalinergic regulation of cardiovascular centers].
Topics: Animals; Blood Pressure; Brain Mapping; Cardiovascular Physiological Phenomena; Cats; Dextromoramide; Dogs; Enkephalin, Methionine; Enkephalins; Heart Rate; Medulla Oblongata; Naloxone; Naltrexone; Nervous System Physiological Phenomena; Pressoreceptors; Rats; Receptors, Opioid; Reflex; Reticular Formation; Sympathetic Nervous System; Vagus Nerve; Vasomotor System | 1985 |
Opiate receptor upregulation and functional supersensitivity.
Topics: Animals; Autoradiography; Brain Chemistry; Cerebral Cortex; Corpus Striatum; Enkephalin, Methionine; Hypothalamus; Naltrexone; Narcotics; Nucleus Accumbens; Periaqueductal Gray; Rats; Receptors, Opioid; Thalamic Nuclei; Time Factors | 1984 |
The role of opioid peptides in memory and learning.
Topics: Amnesia; Animals; beta-Endorphin; Brain; Dopamine; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Humans; Learning; Memory; Naloxone; Naltrexone; Norepinephrine; Rats | 1980 |
Interaction of opioid growth factor (OGF) and opioid antagonist and their significance in cancer therapy.
Topics: Animals; Enkephalin, Methionine; Humans; Naltrexone; Narcotic Antagonists; Neoplasms | 2019 |
157 other study(ies) available for naltrexone and enkephalin, methionine
| Article | Year |
|---|---|
Perinatal morphine exposure alters peptidergic development in the striatum.
Topics: Animals; Blotting, Northern; Body Weight; Corpus Striatum; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Growth; Immunohistochemistry; In Situ Hybridization; Morphine; Naloxone; Naltrexone; Protein Precursors; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Substance P | 1992 |
An opioid growth factor regulates the replication of microorganisms.
Topics: Enkephalin, Methionine; Growth Substances; Naltrexone; Pseudomonas aeruginosa; Receptors, Opioid; Serratia marcescens; Staphylococcus aureus | 1992 |
Immunosuppressive effect of delta-opioid receptor antagonist on xenogeneic mixed lymphocyte reaction.
Topics: Analgesics; beta-Endorphin; Cell Survival; Cells, Cultured; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Humans; Immunosuppressive Agents; Indoles; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Lymphocytes; Morphinans; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta | 1992 |
Kappa-opioid receptor stimulation abolishes mu- but not delta-mediated inhibitory control of spinal Met-enkephalin release.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Indoles; Injections, Spinal; Male; Morphinans; Naloxone; Naltrexone; Neurons; Oligopeptides; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1992 |
Endopeptidase 24.15 inhibition and opioid antinociception.
Topics: Amino Acid Sequence; Analgesics; Animals; Dynorphins; Enkephalin, Methionine; Male; Metalloendopeptidases; Molecular Sequence Data; Naltrexone; Narcotics; Pain Measurement; Protease Inhibitors; Rats; Rats, Inbred Strains; Reaction Time | 1992 |
Chronic naltrexone treatment of rats: effects on gastrointestinal opioid peptide content.
Topics: Animals; beta-Endorphin; Digestive System; Duodenum; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Jejunum; Male; Naltrexone; Pyloric Antrum; Radioimmunoassay; Radioligand Assay; Rats; Rats, Wistar | 1992 |
The central effect of methionine-enkephalin on NK cell activity.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Enkephalin, Methionine; Female; Injections, Intraperitoneal; Injections, Intravenous; Killer Cells, Natural; Mice; Mice, Inbred BALB C; Microinjections; Naltrexone; Poly I-C | 1992 |
Feedback inhibition of met-enkephalin release from the rat spinal cord in vivo.
Topics: Animals; Calcitonin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Feedback; Indoles; Injections, Spinal; Leucine; Male; Morphinans; Naloxone; Naltrexone; Oligopeptides; Radioimmunoassay; Rats; Rats, Inbred Strains; Spinal Cord; Thiorphan | 1992 |
Endogenous opioids regulate cell proliferation in the retina of developing rat.
Topics: Animals; Animals, Newborn; Autoradiography; Cell Division; DNA Replication; Endorphins; Enkephalin, Methionine; Female; Iodine Radioisotopes; Male; Mitotic Index; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Retina; Retinal Ganglion Cells; Thymidine | 1991 |
Opioid mu and delta receptor antagonists reduce wet dog shaking elicited by perforant path stimulation.
Topics: Animals; Dynorphins; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Methionine; gamma-Aminobutyric Acid; Hippocampus; Male; Naltrexone; Peptide Fragments; Rats; Rats, Inbred F344; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Stereotyped Behavior | 1991 |
In vivo enhancement of NK cell activity with met-enkephalin and glycyl-glutamine: their possible role in the conditioned response.
Topics: Animals; Conditioning, Psychological; Dipeptides; Enkephalin, Methionine; In Vitro Techniques; Killer Cells, Natural; Male; Mice; Mice, Inbred BALB C; Naltrexone; Poly I-C; Spleen; Stimulation, Chemical | 1991 |
Facilitation of dimethylbenz[a]anthracene-induced rat mammary tumorigenesis by restraint stress: role of beta-endorphin, prolactin and naltrexone.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; beta-Endorphin; Eating; Endorphins; Enkephalin, Methionine; Female; Immune System; Lymphocyte Activation; Mammary Neoplasms, Experimental; Naltrexone; Neurosecretory Systems; Prolactin; Rats; Rats, Inbred F344; Stress, Physiological | 1991 |
Kappa opioid partial agonist activity of the enkephalin-like pentapeptide BW942C based on urination and in vitro studies in humans and animals.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adult; Amino Acid Sequence; Animals; Diuresis; Dose-Response Relationship, Drug; Drug Tolerance; Enkephalin, Methionine; Enkephalins; Humans; In Vitro Techniques; Male; Molecular Sequence Data; Morphine; Naltrexone; Oligopeptides; Phenazocine; Pyrrolidines; Rabbits; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Urination; Vas Deferens | 1990 |
Cardiovascular action of methionine enkephalin (met-enkephalin) in conscious and anesthetized rabbits.
Topics: Anesthesia; Animals; Blood Pressure; Cardiovascular Physiological Phenomena; Cardiovascular System; Consciousness; Enkephalin, Methionine; Male; Naltrexone; Rabbits; Receptors, Opioid; Receptors, Opioid, mu | 1990 |
Opioid antagonist (naltrexone) stimulation of cell proliferation in human and animal neuroblastoma and human fibrosarcoma cells in culture.
Topics: Animals; Cell Division; Enkephalin, Methionine; Fibrosarcoma; Humans; Mice; Mitosis; Naltrexone; Neuroblastoma; Tumor Cells, Cultured | 1990 |
Down-regulation of proopiomelanocortin synthesis and beta-endorphin utilization in hypothalamus of morphine-tolerant rats.
Topics: Animals; beta-Endorphin; Corpus Striatum; Drug Tolerance; Enkephalin, Methionine; Enkephalins; Hypothalamus; Male; Morphine; Naltrexone; Pro-Opiomelanocortin; Protein Precursors; Rats; Rats, Inbred Strains; Reference Values; RNA, Messenger; Substance Withdrawal Syndrome | 1989 |
Adrenal vein catecholamines and met-enkephalin during staged hemorrhage and naltrexone administration in cats.
Topics: Adrenal Glands; Animals; Blood Pressure; Body Weight; Catecholamines; Cats; Chromatography, High Pressure Liquid; Enkephalin, Methionine; Epinephrine; Female; Femoral Artery; Femoral Vein; Hemorrhage; Male; Naltrexone; Norepinephrine; Receptors, Opioid | 1989 |
Modulation of mu-mediated antinociception by delta agonists: characterization with antagonists.
Topics: Analgesics; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1989 |
Opioid modulation of feeding and drinking in fowls.
Topics: Animals; Chickens; Drinking; Eating; Enkephalin, Methionine; Female; Injections, Intramuscular; Injections, Intravenous; Injections, Intraventricular; Naloxone; Naltrexone; Time Factors | 1989 |
Respiratory and neuroendocrine responses of piglets to hypoxia during postnatal development.
Topics: Adenosine; Age Factors; Animals; Enkephalin, Methionine; Epinephrine; Hypoxia; Naltrexone; Norepinephrine; Receptors, Opioid; Respiration; Swine | 1987 |
Analeptic effect of opiate receptor agonists in rabbits.
Topics: Animals; Arousal; Brain; Central Nervous System Stimulants; Codeine; Cyclazocine; Dose-Response Relationship, Drug; Enkephalin, Methionine; Ethylketocyclazocine; Etorphine; Male; Meperidine; Methadone; Morphine; Naltrexone; Narcotics; Phenazocine; Rabbits; Receptors, Opioid; Reflex | 1985 |
The role of the mediobasal arcuate hypothalamus in relation to opioid systems in the control of ingestive behaviour in the rat.
Topics: Animals; Arcuate Nucleus of Hypothalamus; Body Weight; Brain Chemistry; Circadian Rhythm; Dexamethasone; Dynorphins; Endorphins; Enkephalin, Methionine; Feeding Behavior; Food Deprivation; Male; Naltrexone; Rats; Rats, Inbred Strains | 1986 |
Impaired learning of classically conditioned bradycardia in rats following fourth ventricle administration of D-Ala2-methionine-enkephalinamide.
Topics: Animals; Bradycardia; Cerebral Ventricles; Conditioning, Classical; Enkephalin, Methionine; Heart Rate; Injections, Intraventricular; Learning; Male; Naltrexone; Rats; Rats, Inbred Strains | 1989 |
Pharmacological evidence of a central effect of naltrexone, morphine, and beta-endorphin and a peripheral effect of met- and leu-enkephalin on retention of an inhibitory response in mice.
Topics: Adrenal Medulla; Animals; Avoidance Learning; beta-Endorphin; Brain; Drug Interactions; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Male; Memory; Mice; Morphine; Naltrexone; Quaternary Ammonium Compounds; Retention, Psychology | 1985 |
Opioid receptor binding characteristics of the non-equilibrium mu antagonist, beta-funaltrexamine (beta-FNA).
Topics: Animals; Brain; Enkephalin, Methionine; In Vitro Techniques; Ligands; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tritium | 1985 |
Receptors for opioid peptides in the guinea-pig ileum.
Topics: Alkylation; Animals; Dose-Response Relationship, Drug; Electric Stimulation; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Ileum; Male; Mice; Naloxone; Naltrexone; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Vas Deferens | 1985 |
An opiate receptor-associated aminopeptidase that degrades enkephalins.
Topics: Aminopeptidases; Animals; Anti-Bacterial Agents; Brain; Chromatography, Affinity; Enkephalin, Methionine; Enkephalins; Hydrogen-Ion Concentration; In Vitro Techniques; Naltrexone; Oligopeptides; Peptides; Rats; Receptors, Opioid | 1985 |
An assessment of the role of opioid receptors in the response to cannabimimetic drugs.
Topics: Adenylyl Cyclase Inhibitors; Animals; Cannabinoids; Cell Line; Dronabinol; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Etorphine; Morphine; Naltrexone; Neuroblastoma; Neurons; Receptors, Opioid; Receptors, Opioid, delta | 1986 |
Endogenous opioid systems and neural cancer: transmission and scanning electron microscopic studies of murine neuroblastoma in tissue culture.
Topics: Enkephalin, Methionine; Male; Microscopy, Electron, Scanning; Naloxone; Naltrexone; Neuroblastoma; Time Factors; Tumor Cells, Cultured | 1988 |
Effect of endorphins on heart rate and blood pressure in adult dogs.
Topics: Animals; Atropine; Blood Pressure; Consciousness; Dogs; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Heart; Heart Rate; Naloxone; Naltrexone | 1986 |
Endogenous opioid systems regulate cell proliferation in the developing rat brain.
Topics: Animals; Animals, Newborn; Autoradiography; Cell Division; Cerebellum; Endorphins; Enkephalin, Methionine; Female; Male; Naltrexone; Rats; Rats, Inbred Strains | 1987 |
Enkephalin release into the ventral tegmental area in response to stress: modulation of mesocorticolimbic dopamine.
Topics: Animals; Dopamine; Electroshock; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Frontal Lobe; Male; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Septal Nuclei; Stress, Physiological; Tegmentum Mesencephali | 1987 |
Effect of morphine treatment and withdrawal on endogenous methionine- and leucine-enkephalin levels in primate brain.
Topics: Animals; Brain Chemistry; Chlorocebus aethiops; Enkephalin, Leucine; Enkephalin, Methionine; Female; Male; Morphine; Naltrexone; Substance Withdrawal Syndrome | 1986 |
Cholecystokinin antagonists selectively potentiate analgesia induced by endogenous opiates.
Topics: Analgesia; Animals; Cholecystokinin; Drug Synergism; Electroshock; Endorphins; Enkephalin, Methionine; Injections, Spinal; Male; Naltrexone; Norepinephrine; Proglumide; Rats; Rats, Inbred Strains; Spinal Cord | 1985 |
Enhancement of colonic motor response to feeding by central endogenous opiates in the dog.
Topics: Animals; Colon; Dogs; Eating; Endorphins; Enkephalin, Methionine; Female; Gastrointestinal Motility; Humans; Mice; Naltrexone; Neprilysin; Protease Inhibitors; Thiorphan; Tiopronin | 1985 |
Asymmetric behavior induced by enkephalinergic agents in the basal ganglia.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Ganglia, Spinal; Male; Naloxone; Naltrexone; Rats; Rats, Inbred Strains | 1985 |
Antagonism of diazepam-induced feeding in rats by antisera to opioid peptides.
Topics: Animals; beta-Endorphin; Dexamethasone; Diazepam; Endorphins; Enkephalin, Methionine; Feeding Behavior; Immune Sera; Male; Naloxone; Naltrexone; Pituitary Gland; Rats; Rats, Inbred Strains; Thyrotropin-Releasing Hormone | 1984 |
Opiate-receptor interactions on single locus coeruleus neurones.
Topics: Action Potentials; Animals; Enkephalin, Methionine; In Vitro Techniques; Locus Coeruleus; Morphine Derivatives; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Neurons; Rats; Receptors, Opioid | 1984 |
The in vitro pharmacology of D-Met2,Pro5-enkephalinamide.
Topics: Animals; Endorphins; Enkephalin, Methionine; Enkephalins; In Vitro Techniques; Kinetics; Male; Muscle Contraction; Muscle, Smooth; Naltrexone; Narcotics; Nictitating Membrane; Rats; Receptors, Opioid; Vas Deferens | 1981 |
Suppression of ethanol consumption by MET-enkephalin in rats.
Topics: Alcohol Drinking; Animals; Depression, Chemical; Endorphins; Enkephalin, Methionine; Enkephalins; Injections, Intraventricular; Male; Naltrexone; Rats | 1982 |
Evidence for a role of the ventro-medial posterior hypothalamus in nociceptive processes in the rat.
Topics: Animals; beta-Endorphin; Dynorphins; Electroshock; Endorphins; Enkephalin, Methionine; Hypothalamus; Hypothalamus, Posterior; Male; Morphine; Naltrexone; Nociceptors; Pain; Protein Precursors; Rats; Rats, Inbred Strains; Stereotaxic Techniques | 1983 |
Opioid peptides and seizures in the spontaneously epileptic Mongolian gerbil.
Topics: Animals; beta-Endorphin; Cerebral Cortex; Dynorphins; Endorphins; Enkephalin, Methionine; Epilepsy; Gerbillinae; Morphine; Naltrexone; Narcotics; Seizures | 1983 |
Seasonal variation in the apparent number of binding sites for 3H-opioid agonists and antagonists.
Topics: Animals; Binding Sites; Brain; Dihydromorphine; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Kinetics; Male; Mice; Morphinans; Morphine; Naloxone; Naltrexone; Receptors, Opioid; Seasons | 1981 |
Irreversible inactivation of the opiate receptors in the neuroblastoma x glioma hybrid NG108-15 by chlornaltrexamine.
Topics: Animals; Cyclic AMP; Enkephalin, Methionine; Enkephalins; Glioma; Hybrid Cells; Mice; Naloxone; Naltrexone; Neoplasms, Experimental; Neuroblastoma; Nitrogen Mustard Compounds; Prostaglandins E, Synthetic; Rats; Receptors, Opioid | 1981 |
Effects of opioid peptides on thermoregulation.
Topics: Animals; beta-Endorphin; Body Temperature Regulation; Cats; Cattle; Endorphins; Enkephalin, Methionine; Enkephalins; Mice; Naloxone; Naltrexone; Narcotics; Rats; Structure-Activity Relationship | 1981 |
D-Ala2-Met-enkephalinamide, a potent opioid peptide, alters pituitary-adrenocortical secretion in rats.
Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Animals; Corticosterone; Dexamethasone; Enkephalin, Methionine; Hypophysectomy; Kinetics; Male; Naltrexone; Pituitary Gland; Rats; Rats, Inbred Strains | 1982 |
Intraseptally injected opiate agents: effects on morphine-induced behaviour of cats.
Topics: Animals; Behavior, Animal; beta-Endorphin; Cats; Endorphins; Enkephalin, Methionine; Fentanyl; Morphine; Naloxone; Naltrexone; Narcotics; Receptors, Opioid; Septal Nuclei; Septum Pellucidum | 1982 |
Protection of opiate receptors in NG108-15 against modification by N-ethylmaleimide.
Topics: Animals; Cell Line; Dithiothreitol; Enkephalin, Methionine; Ethylmaleimide; Glioma; Hybrid Cells; Kinetics; Mice; Naloxone; Naltrexone; Neuroblastoma; Rats; Receptors, Opioid; Sulfhydryl Reagents | 1983 |
Naltrexone-sensitive behavioral actions of the ACTH 4-9 analog (Org 2766).
Topics: Adrenocorticotropic Hormone; Animals; Avoidance Learning; Behavior, Animal; beta-Endorphin; Electric Stimulation; Endorphins; Enkephalin, Methionine; Grooming; Male; Naloxone; Naltrexone; Oligopeptides; Peptide Fragments; Rats; Rats, Inbred Strains; Self Stimulation | 1983 |
Multi-dimensional analyses of behavior in mice treated with morphine, endorphins and [des-tyrosine1]-gamma-endorphin.
Topics: Animals; Behavior, Animal; beta-Endorphin; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Injections, Intraventricular; Male; Mice; Morphine; Naltrexone; Peptide Fragments | 1983 |
Nonspecific convulsions are induced by morphine but not D-Ala2-methionine-enkephalinamide at cortical sites.
Topics: Animals; Cerebral Cortex; Drug Tolerance; Electroencephalography; Enkephalin, Methionine; Evoked Potentials; Injections, Intraventricular; Male; Methadone; Morphine; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Seizures | 1984 |
Visualization of opiate receptor upregulation by light microscopy autoradiography.
Topics: Animals; Autoradiography; Brain; Brain Chemistry; Brain Mapping; Enkephalin, Methionine; Male; Naloxone; Naltrexone; Rats; Receptors, Opioid | 1984 |
Endogenous opiates and stress ulceration.
Topics: Animals; Endorphins; Enkephalin, Methionine; Gastric Acid; Male; Naltrexone; Peptic Ulcer; Rats; Stress, Physiological | 1982 |
Interaction between nicotine and endogenous opioid mechanisms in the unanesthetized dog.
Topics: Animals; Body Temperature; Brain; Dogs; Endorphins; Enkephalin, Methionine; Female; Heart Rate; Injections, Intraventricular; Naltrexone; Nicotine; Pupil; Reflex; Respiration; Skin Physiological Phenomena | 1982 |
Spinal delta 2-, but not delta 1-, mu-, or kappa-opioid receptors are involved in the tail-flick inhibition induced by beta-endorphin from nucleus raphe obscurus in the pentobarbital-anesthetized rat.
Topics: Amino Acid Sequence; Analgesia; Animals; Benzylidene Compounds; beta-Endorphin; Dose-Response Relationship, Drug; Enkephalin, Methionine; Injections, Intraventricular; Injections, Spinal; Male; Molecular Sequence Data; Naltrexone; Narcotic Antagonists; Pentobarbital; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin; Spinal Cord; Tail | 1995 |
Opioids and nitric oxide contribute to hypoxia-induced pial arterial vasodilation in newborn pigs.
Topics: Amino Acid Oxidoreductases; Analysis of Variance; Animals; Animals, Newborn; Arginine; Arterioles; Cerebral Arteries; Cyclic GMP; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Female; Hypoxia; Male; Muscle, Smooth, Vascular; Naltrexone; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Nitroprusside; Receptors, Opioid, kappa; Receptors, Opioid, mu; Swine; Vasodilation | 1995 |
Delta opioid agonists inhibit proliferation of highlypurified murine CD4+ and CD8+ T-cells.
Topics: Analgesics; Animals; CD4 Antigens; CD8 Antigens; Cell Division; Cells, Cultured; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Female; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; T-Lymphocytes | 1995 |
Opioid growth factor modulates corneal epithelial outgrowth in tissue culture.
Topics: Animals; Cell Division; Cornea; Culture Media, Serum-Free; Culture Techniques; Endorphins; Enkephalin, Methionine; Epithelial Cells; Epithelium; Growth Substances; Male; Naltrexone; Rabbits; Receptors, Opioid; Tissue Distribution | 1995 |
Delta-opioid receptor agonists inhibit neuromuscular transmission in human colon.
Topics: Analgesics; Analgesics, Opioid; Colon; Dynorphins; Electric Stimulation; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Gastrointestinal Motility; Humans; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Neuromuscular Junction; Peptide Fragments; Receptors, Opioid, delta; Synaptic Transmission | 1994 |
Differential effects of methionine enkephalin on the growth of brain tumor cells.
Topics: Astrocytoma; Brain Neoplasms; Cell Division; Enkephalin, Methionine; Humans; Naltrexone; Neuroblastoma; Signal Transduction; Tumor Cells, Cultured | 1994 |
Receptor-mediated regulation of neuropeptide gene expression in astrocytes.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Astrocytes; Benzomorphans; Brain; Enkephalin, Methionine; Etorphine; Gene Expression Regulation; Morphine; Naltrexone; Nerve Tissue Proteins; Neuropeptides; Organ Specificity; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; Receptors, Opioid | 1994 |
Morphine reduces the release of met-enkephalin-like material from the rat spinal cord in vivo by acting at delta opioid receptors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Injections, Spinal; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pyrrolidines; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Spinal Cord | 1994 |
Antitussive effect of [Met5]enkephalin-Arg6-Phe7 in mice.
Topics: Animals; Antitussive Agents; Capsaicin; Cough; Dose-Response Relationship, Drug; Enkephalin, Methionine; Injections, Intraventricular; Male; Mice; Naltrexone; Narcotic Antagonists; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1994 |
Effects of the enkephalin analog (D-Met2,Pro5)-enkephalinamide on alpha-melanocyte-stimulating hormone secretion.
Topics: alpha-MSH; Animals; Dose-Response Relationship, Drug; Enkephalin, Methionine; Male; Naltrexone; Pituitary Gland; Rats; Rats, Sprague-Dawley; Time Factors | 1993 |
Enkephalin antinociception in mice is mediated by delta 1- and delta 2-opioid receptors in the brain and spinal cord, respectively.
Topics: Animals; Benzylidene Compounds; beta-Endorphin; Brain; Enkephalin, Leucine; Enkephalin, Methionine; Injections, Intraventricular; Injections, Spinal; Male; Mice; Naltrexone; Pain; Receptors, Opioid, delta; Spinal Cord | 1993 |
L-arginine exerts a dual role in nociceptive processing in the brain: involvement of the kyotorphin-Met-enkephalin pathway and NO-cyclic GMP pathway.
Topics: Analgesics; Animals; Arginine; Brain; Cyclic GMP; Endorphins; Enkephalin, Methionine; Injections, Intraventricular; Male; Methylene Blue; Mice; Mice, Inbred Strains; Naloxone; Naltrexone; Narcotic Antagonists; Neural Pathways; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nociceptors; Pain Measurement; Spinal Cord | 1993 |
Kinetic parameters of antagonism by the delta opioid receptor selective peptide antagonist Boc-Tyr-Pro-Gly-Phe-Leu-Thr against selective and non-selective agonists in the mouse vas deferens.
Topics: Analgesics; Animals; Anticonvulsants; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; In Vitro Techniques; Kinetics; Male; Mice; Mice, Inbred Strains; Morphine Derivatives; Naltrexone; Oligopeptides; Pyrroles; Receptors, Opioid, delta; Thiophenes; Vas Deferens | 1993 |
Role of endogenous opioids in progesterone antagonism on oestradiol-induced DNA synthesis in the rat uterus.
Topics: Animals; Cell Division; DNA; Endorphins; Enkephalin, Methionine; Estradiol; Female; Immunization, Passive; Naltrexone; Ovariectomy; Progesterone; Rats; Uterus | 1993 |
The opioid growth factor, [Met5]-enkephalin, and the zeta opioid receptor are present in human and mouse skin and tonically act to inhibit DNA synthesis in the epidermis.
Topics: Animals; Circadian Rhythm; Culture Techniques; DNA; Enkephalin, Methionine; Epidermis; Growth Substances; Humans; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Naltrexone; Narcotic Antagonists; Oligopeptides; Opioid Peptides; Receptors, Opioid; Skin | 1996 |
Endogenous opioids may modulate the activity of the hypothalamus-pituitary-adrenocortical axis in domestic fowl.
Topics: Animals; Catecholamines; Chickens; Corticosterone; Endorphins; Enkephalin, Methionine; Female; Glucocorticoids; Hypothalamo-Hypophyseal System; Naltrexone; Narcotic Antagonists; Opioid Peptides; Pituitary-Adrenal System; Protein Precursors; Stress, Physiological | 1996 |
Opioid growth factor-dependent DNA synthesis in the neonatal rat aorta.
Topics: Animals; Animals, Newborn; Aorta; DNA; Endorphins; Enkephalin, Methionine; Female; Fibroblasts; Growth Substances; Immunohistochemistry; Male; Muscle, Smooth, Vascular; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid | 1996 |
Gene-peptide relationships in the developing rat brain: the response of preproenkephalin mRNA and [Met5]-enkephalin to acute opioid antagonist (naltrexone) exposure.
Topics: Animals; Caudate Nucleus; Cerebellum; Enkephalin, Methionine; Enkephalins; Female; Male; Naltrexone; Narcotic Antagonists; Protein Precursors; Putamen; Random Allocation; Rats; Rats, Sprague-Dawley; RNA, Messenger; Time Factors | 1995 |
Naltrindole sensitive delta 2 opioid receptor mediates invertebrate immunocyte activation.
Topics: Animals; Bivalvia; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Humans; Immune System; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta | 1995 |
Endogenous opioid peptide mediation of hypoalgesic response in long-term diabetic rats.
Topics: Analysis of Variance; Animals; Blood Glucose; Body Weight; Chronic Disease; Diabetes Mellitus, Experimental; Endorphins; Enkephalin, Methionine; Half-Life; Hypoglycemic Agents; Insulin; Male; Naltrexone; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley | 1996 |
Delta-Opioid receptor modulation of the release of substance P-like immunoreactivity in the dorsal horn of the rat following mechanical or thermal noxious stimulation.
Topics: Animals; Decerebrate State; Enkephalin, Methionine; Functional Laterality; Hindlimb; Hot Temperature; Male; Naltrexone; Narcotic Antagonists; Pain; Physical Stimulation; Rats; Rats, Wistar; Receptors, Opioid, delta; Spinal Cord; Substance P; Time Factors | 1996 |
Activation of mu-opioid receptors are required for the conditioned enhancement of NK cell activity.
Topics: Animals; beta-Endorphin; Enkephalin, Leucine; Enkephalin, Methionine; Injections, Spinal; Killer Cells, Natural; Mice; Mice, Inbred BALB C; Morphinans; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu | 1996 |
Opioid growth factor is present in human and mouse gastrointestinal tract and inhibits DNA synthesis.
Topics: Animals; Cells, Cultured; Circadian Rhythm; DNA; DNA Replication; Enkephalin, Methionine; Esophagus; Gastric Mucosa; Growth Substances; Homeostasis; Humans; Intestinal Mucosa; Intestine, Large; Intestine, Small; Kinetics; Male; Mice; Mice, Inbred C57BL; Mitotic Index; Mucous Membrane; Naloxone; Naltrexone; Receptors, Opioid; Thymidine; Time Factors | 1997 |
Homeostasis of ocular surface epithelium in the rat is regulated by opioid growth factor.
Topics: Animals; Circadian Rhythm; Culture Techniques; DNA; Enkephalin, Methionine; Epithelial Cells; Epithelium; Eye; Growth Substances; Homeostasis; Immunohistochemistry; Male; Naltrexone; Narcotic Antagonists; Ocular Physiological Phenomena; Opioid Peptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Tissue Distribution | 1997 |
Use of antisense oligodeoxynucleotide to delta-opioid receptor mRNA in the study of turnover of delta-opioid receptors in the spinal cord of the mouse.
Topics: Animals; Enkephalin, Methionine; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Oligonucleotides, Antisense; Oligopeptides; Pain Measurement; Protease Inhibitors; Receptors, Opioid, delta; RNA, Messenger; Spinal Cord; Thiorphan | 1997 |
Enkephalins modulate differentiation of normal human keratinocytes in vitro.
Topics: beta-Endorphin; Cell Differentiation; Cell Division; Cells, Cultured; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Humans; Keratinocytes; Keratins; Melphalan; Naltrexone; Narcotic Antagonists; Skin; Transglutaminases | 1997 |
Opioid receptor-mediated inhibition of omega-conotoxin GVIA-sensitive calcium channel currents in rat intracardiac neurons.
Topics: Acetylcholine; Animals; Animals, Newborn; Anti-Arrhythmia Agents; Benzomorphans; Calcium; Calcium Channels; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Heart Conduction System; Ion Channel Gating; Ion Transport; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; omega-Conotoxin GVIA; Parasympathetic Nervous System; Patch-Clamp Techniques; Peptides; Pertussis Toxin; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Virulence Factors, Bordetella | 1998 |
Role of opioids in hypoxic pial artery dilation is stimulus duration dependent.
Topics: Animals; Arteries; Dynorphins; Enkephalin, Methionine; Female; Hypoxia, Brain; Male; Naltrexone; Narcotic Antagonists; Opioid Peptides; Pia Mater; Swine; Vasodilation | 1998 |
Re-epithelialization of the rabbit cornea is regulated by opioid growth factor.
Topics: Animals; Enkephalin, Methionine; Epithelium, Corneal; Fluorescein; Immunohistochemistry; In Vitro Techniques; Naltrexone; Rabbits; Receptors, Opioid; Time Factors; Wound Healing | 1998 |
Inhibition of the neuronal nicotinic receptor-mediated current by kappa opioid receptor agonists in PC12 cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Dynorphins; Electric Conductivity; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Naltrexone; Narcotic Antagonists; Neurons; Nicotinic Antagonists; PC12 Cells; Rats; Receptors, Nicotinic; Receptors, Opioid, kappa | 1998 |
5-HT4 receptor agonists and delta-opioid receptor antagonists act synergistically to stimulate colonic propulsion.
Topics: Animals; Benzeneacetamides; Colon; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Guinea Pigs; In Vitro Techniques; Male; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Peptide Fragments; Peristalsis; Pyrrolidines; Receptors, Opioid, delta; Receptors, Serotonin; Receptors, Serotonin, 5-HT4; Serotonin Receptor Agonists; Somatostatin | 1998 |
Effects of peptidase inhibitors on the enkephalin-induced anti-nociception in rats.
Topics: Animals; Anti-Bacterial Agents; Area Under Curve; Captopril; Dose-Response Relationship, Drug; Drug Therapy, Combination; Enkephalin, Methionine; Glycopeptides; Injections, Intraventricular; Injections, Subcutaneous; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Pain; Pain Measurement; Peptides; Protease Inhibitors; Rats; Rats, Wistar | 1998 |
Irreversible labelling of the opioid receptors by a melphalan-substituted [Met5]enkephalin-Arg-Phe derivative.
Topics: Affinity Labels; Amino Acid Sequence; Amino Acid Substitution; Animals; Binding Sites; Binding, Competitive; Brain; Enkephalin, Methionine; Female; Guinea Pigs; Male; Melphalan; Membranes; Naloxone; Naltrexone; Narcotic Antagonists; Radioligand Assay; Rats; Receptors, Opioid | 1999 |
Endomorphin-1 and endomorphin-2, endogenous ligands for the mu-opioid receptor, inhibit electrical activity of rat rostral ventrolateral medulla neurons in vitro.
Topics: Animals; Electrophysiology; Enkephalin, Methionine; In Vitro Techniques; Ligands; Male; Medulla Oblongata; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Nociceptin; Oligopeptides; Opioid Peptides; Perfusion; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 1999 |
Opioid growth factor and organ development in rat and human embryos.
Topics: Animals; Brain; Brain Chemistry; DNA; Ectoderm; Embryonic and Fetal Development; Endoderm; Enkephalin, Methionine; Enkephalins; Female; Fetus; Gene Expression Regulation, Developmental; Heart; Humans; Immunohistochemistry; In Situ Hybridization; Intestines; Male; Mesoderm; Muscles; Myocardium; Naltrexone; Narcotic Antagonists; Pregnancy; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Ribs; RNA, Messenger; Skin; Tongue | 1999 |
Reepithelialization of the human cornea is regulated by endogenous opioids.
Topics: DNA; DNA Replication; Enkephalin, Methionine; Epithelium, Corneal; Fluorescent Antibody Technique, Indirect; Fluorophotometry; Humans; Naltrexone; Narcotic Antagonists; Organ Culture Techniques; Receptors, Opioid; Wound Healing | 2000 |
Modulatory effect of endogenous and exogenous opioids on the excitatory reflex pathway of the rat ileum.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Ileum; In Vitro Techniques; Male; Morphine; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Narcotics; Peristalsis; Rats; Rats, Wistar; Receptors, Opioid; Somatostatin | 2000 |
In vivo effects of chronic treatment with [MET5]-enkephalin on hematological values and natural killer cell activity in athymic mice.
Topics: Animals; Blood Cell Count; Body Weight; Enkephalin, Methionine; Killer Cells, Natural; Leukocyte Count; Male; Mice; Mice, Nude; Naltrexone; Narcotic Antagonists; Organ Size; Spleen | 2000 |
The opioid growth factor, [Met5]-enkephalin, inhibits DNA synthesis during recornification of mouse tail skin.
Topics: Animals; Cell Division; DNA; Enkephalin, Methionine; Epidermal Cells; Epidermis; Growth Substances; Keratinocytes; Male; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Specific Pathogen-Free Organisms; Tail; Thymidine; Tritium; Wound Healing | 2000 |
Altered opioid-mediated control of the spinal release of dynorphin and met-enkephalin in polyarthritic rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia; Animals; Arthritis; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Iodine Radioisotopes; Ligands; Male; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 2000 |
Receptor selectivity of Met-enkephalin-Arg6-Phe7, an endogenous opioid peptide, in cerebral cortex of human and rat.
Topics: Adult; Animals; Benzeneacetamides; Benzomorphans; Binding Sites; Cerebral Cortex; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Ethylketocyclazocine; Female; Humans; Male; Naloxone; Naltrexone; Norepinephrine; Oligopeptides; Peptide Fragments; Peptides; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Somatostatin | 2000 |
Modulation of humoral immune responses in the rat by centrally applied Met-Enk and opioid receptor antagonists: functional interactions of brain OP1, OP2 and OP3 receptors.
Topics: Adjuvants, Immunologic; Animals; Cells, Cultured; Enkephalin, Leucine; Enkephalin, Methionine; Hemolytic Plaque Technique; Immunoglobulins; Immunosuppressive Agents; Injections, Intraventricular; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2000 |
Opioid growth factor regulates the cell cycle of human neoplasias.
Topics: Adenocarcinoma; Carcinoma, Squamous Cell; Cell Cycle; Cell Division; Colonic Neoplasms; DNA Replication; Enkephalin, Methionine; Head and Neck Neoplasms; Humans; Naltrexone; Narcotic Antagonists; Neoplasm Proteins; Neoplasms; Pancreatic Neoplasms; Receptors, Opioid; Resting Phase, Cell Cycle; Tumor Cells, Cultured; Tumor Stem Cell Assay | 2000 |
Expression of functional delta opioid receptors in vascular smooth muscle.
Topics: Animals; Aorta; Binding, Competitive; Calcium; Cell Line; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Gene Expression; Humans; In Vitro Techniques; Male; Membrane Potentials; Muscle, Smooth, Vascular; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; RNA, Messenger; Vasoconstriction | 2000 |
Opioid and GABA receptors involved in mediation and modulation of tonic and stimulus-evoked inhibition of a spinal reflex in the decerebrated and spinalized rabbit.
Topics: Animals; Bicuculline; Conditioning, Classical; Decerebrate State; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Methionine; Female; GABA Antagonists; Male; Muscle Tonus; Naloxone; Naltrexone; Narcotic Antagonists; Organophosphorus Compounds; Rabbits; Receptors, GABA; Receptors, Opioid; Receptors, Opioid, mu; Receptors, sigma; Reflex | 2001 |
Differential antinociceptive effects induced by intrathecally administered endomorphin-1 and endomorphin-2 in the mouse.
Topics: Analgesics; Animals; Benzylidene Compounds; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Methionine; Immune Sera; Injections, Spinal; Injections, Subcutaneous; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain; Pain Measurement; Pain Threshold; Peptide Fragments; Time Factors | 2001 |
The neuropeptide FF analogue, 1DMe, acts as a functional opioid autoreceptor antagonist in the rat spinal cord.
Topics: Animals; Autoreceptors; Dose-Response Relationship, Drug; Enkephalin, Methionine; In Vitro Techniques; Leucine; Male; Naltrexone; Narcotic Antagonists; Oligopeptides; Potassium; Rats; Rats, Sprague-Dawley; Spinal Cord; Thiorphan | 2001 |
Potentiation of the excitatory action of NMDA in ventrolateral periaqueductal gray by the mu-opioid receptor agonist, DAMGO.
Topics: Action Potentials; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enzyme Inhibitors; Ethylmaleimide; Female; Male; N-Methylaspartate; Naltrexone; Narcotic Antagonists; Neural Inhibition; Neural Pathways; Neurons; Organ Culture Techniques; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, mu; Synaptic Transmission | 2002 |
Different effects of methionine-enkephalin on paw edema in two inbred rat strains.
Topics: Animals; Dexamethasone; Dose-Response Relationship, Drug; Edema; Enkephalin, Methionine; Glucocorticoids; Inflammation; Kinetics; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Species Specificity; Time Factors | 2002 |
Naltrexone, an opioid antagonist, facilitates reepithelialization of the cornea in diabetic rat.
Topics: Animals; Corneal Ulcer; Diabetes Mellitus, Experimental; DNA; Enkephalin, Methionine; Epithelial Cells; Epithelium, Corneal; Male; Microscopy, Electron; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Wound Healing | 2002 |
Cardiac enkephalins interrupt vagal bradycardia via delta 2-opioid receptors in sinoatrial node.
Topics: Analgesics; Analgesics, Opioid; Animals; Benzylidene Compounds; Bradycardia; Dogs; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Naltrexone; Narcotic Antagonists; Oligopeptides; Opioid Peptides; Quinolines; Receptors, Opioid, delta; Sinoatrial Node; Vagus Nerve | 2003 |
Opioid modulation of taste responses in the nucleus of the solitary tract.
Topics: Action Potentials; Animals; Cricetinae; Enkephalin, Methionine; Male; Mesocricetus; Naltrexone; Narcotics; Neurons; Receptors, Opioid, delta; Receptors, Opioid, mu; Solitary Nucleus; Taste | 2003 |
Endogenous opioid peptides contribute to antinociceptive potency of intrathecal [Dmt1]DALDA.
Topics: Analgesics, Opioid; Animals; Antibodies, Blocking; Cloning, Molecular; Dynorphins; Endorphins; Enkephalin, Methionine; Guanosine 5'-O-(3-Thiotriphosphate); Hot Temperature; Injections, Intraventricular; Injections, Spinal; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain Measurement; Radioligand Assay; Reaction Time; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2003 |
Opioid growth factor inhibits intimal hyperplasia in balloon-injured rat carotid artery.
Topics: Animals; Carotid Arteries; Carotid Artery Injuries; Catheterization; Cell Division; DNA; Enkephalin, Methionine; Hyperplasia; Immunohistochemistry; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Tunica Intima | 2003 |
Behavioral and neuroendocrine actions of the Met-enkephalin-related peptide MERF.
Topics: Analysis of Variance; Animals; Behavior, Animal; Corticotropin-Releasing Hormone; Dopamine; Enkephalin, Methionine; Exploratory Behavior; Haloperidol; Hormone Antagonists; Hypothalamo-Hypophyseal System; Male; Mice; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Neostriatum; Organ Culture Techniques; Peptide Fragments; Pituitary-Adrenal System | 2003 |
Activation of delta- and kappa-opioid receptors by opioid peptides protects cardiomyocytes via KATP channels.
Topics: Adenosine Triphosphate; Animals; Benzamides; Cardiotonic Agents; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, Methionine; Guanidines; Ischemic Preconditioning, Myocardial; Male; Mitochondria; Morphinans; Myocardial Ischemia; Myocytes, Cardiac; Naltrexone; Narcotic Antagonists; Potassium Channels; Rabbits; Receptors, Opioid, delta; Receptors, Opioid, kappa; Sarcolemma | 2003 |
Sialorphin, a natural inhibitor of rat membrane-bound neutral endopeptidase that displays analgesic activity.
Topics: Amino Acid Sequence; Analgesics; Animals; Enkephalin, Methionine; Formaldehyde; Glycopeptides; Kidney; Leucine; Male; Membrane Proteins; Molecular Sequence Data; Naltrexone; Neprilysin; Pain; Pain Measurement; Prostate; Protease Inhibitors; Protein Precursors; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Salivary Proteins and Peptides; Spinal Cord; Submandibular Gland; Substance P; Thiorphan; Wounds and Injuries | 2003 |
An opioid basis for early-phase isoflurane-induced hypotension in rats.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Antibodies, Blocking; beta-Endorphin; Blood Pressure; Endorphins; Enkephalin, Methionine; Hot Temperature; Hypotension; Injections, Intraventricular; Isoflurane; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid; Urethane | 2003 |
Differential regulation of hippocampal progenitor proliferation by opioid receptor antagonists in running and non-running spontaneously hypertensive rats.
Topics: Adrenocorticotropic Hormone; Animals; Behavior, Animal; beta-Endorphin; Bromodeoxyuridine; Cell Division; Corticosterone; Enkephalin, Methionine; Female; Hippocampus; Motor Activity; Naltrexone; Narcotic Antagonists; Narcotics; Physical Conditioning, Animal; Radioimmunoassay; Random Allocation; Rats; Rats, Inbred SHR; Receptors, Opioid; Running | 2004 |
Relative contribution of endogenous opioids to myocardial ischemic tolerance.
Topics: Animals; Dynorphins; Endorphins; Enkephalin, Methionine; In Vitro Techniques; Ischemic Preconditioning, Myocardial; Naltrexone; Narcotic Antagonists; Rabbits; Receptors, Opioid, delta; Receptors, Opioid, kappa; Recovery of Function; Ventricular Function, Left | 2004 |
Opioid growth factor (OGF) inhibits anchorage-independent growth in human cancer cells.
Topics: Adenocarcinoma; Carcinoma, Squamous Cell; Cell Adhesion; Cell Division; Colonic Neoplasms; Colony-Forming Units Assay; Enkephalin, Methionine; Head and Neck Neoplasms; Humans; Naloxone; Naltrexone; Narcotic Antagonists; Pancreatic Neoplasms; Receptors, Opioid; Transplantation, Heterologous; Tumor Cells, Cultured | 2004 |
The antinociceptive effect of Delta9-tetrahydrocannabinol in the arthritic rat.
Topics: Animals; Arthritis, Experimental; Cannabinoid Receptor Antagonists; Dose-Response Relationship, Drug; Dronabinol; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Freund's Adjuvant; Injections, Intradermal; Injections, Intraperitoneal; Male; Morphine; Mycobacterium; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Opioid; Rimonabant | 2004 |
Nucleocytoplasmic distribution of opioid growth factor and its receptor in tongue epithelium.
Topics: Animals; beta Karyopherins; Cell Nucleus; Cell Proliferation; Cytoplasm; Enkephalin, Methionine; Fluorescent Antibody Technique, Indirect; Keratinocytes; Microscopy, Confocal; Microscopy, Immunoelectron; Naltrexone; Narcotic Antagonists; Nuclear Localization Signals; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Tongue | 2005 |
Effects of met-enkephalin on cell proliferation in different models of adrenocortical-cell growth.
Topics: Adrenal Cortex; Animals; Cell Proliferation; Cells, Cultured; Enkephalin, Methionine; Female; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid; Regeneration; Vincristine | 2005 |
Opioids and differentiation in human cancer cells.
Topics: Actins; Cell Differentiation; Cell Line, Tumor; Cell Nucleus; Cell Shape; Cytoskeletal Proteins; Enkephalin, Methionine; Humans; Naltrexone; Narcotic Antagonists; Protein Precursors; Tubulin | 2005 |
Vagotonic effects of enkephalin are not mediated by sympatholytic mechanisms.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Dogs; Enkephalin, Methionine; Female; Heart Rate; Male; Naltrexone; Receptors, Opioid, kappa; Sympatholytics; Vagus Nerve | 2006 |
Simultaneous activation of the delta opioid receptor (deltaOR)/sensory neuron-specific receptor-4 (SNSR-4) hetero-oligomer by the mixed bivalent agonist bovine adrenal medulla peptide 22 activates SNSR-4 but inhibits deltaOR signaling.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Cells, Cultured; Endocytosis; Enkephalin, Methionine; Ganglia, Spinal; Humans; Naltrexone; Neurons, Afferent; Protein Kinase C; Protein Precursors; Rats; Rats, Long-Evans; Receptors, G-Protein-Coupled; Receptors, Opioid, delta; Signal Transduction | 2006 |
Repeated delta1-opioid receptor stimulation reduces delta2-opioid receptor responses in the SA node.
Topics: Analgesics; Analgesics, Opioid; Animals; Benzylidene Compounds; Bradycardia; Dogs; Dose-Response Relationship, Drug; Enkephalin, Methionine; Female; Male; Microdialysis; Naltrexone; Narcotic Antagonists; Oligopeptides; Quinolines; Receptors, Opioid, delta; Sinoatrial Node; Stimulation, Chemical; Vagus Nerve | 2006 |
The monosialosyl ganglioside GM-1 reduces the vagolytic efficacy of delta2-opioid receptor stimulation.
Topics: Analgesics, Opioid; Animals; Benzylidene Compounds; Bradycardia; Dogs; Dose-Response Relationship, Drug; Enkephalin, Methionine; Female; G(M1) Ganglioside; Male; Naltrexone; Narcotic Antagonists; Oligopeptides; Receptors, Opioid, delta; Sinoatrial Node; Stimulation, Chemical; Vagus Nerve | 2006 |
Involvement of delta-and mu-opioid receptors in the delayed cerebral ischemic tolerance induced by repeated electroacupuncture preconditioning in rats.
Topics: Animals; Brain Ischemia; Electroacupuncture; Enkephalin, Methionine; Immunohistochemistry; Ischemic Preconditioning; Male; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Somatostatin | 2007 |
Opioids and migration, chemotaxis, invasion, and adhesion of human cancer cells.
Topics: Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Physiological Phenomena; Chemotaxis; Dose-Response Relationship, Drug; Enkephalin, Methionine; Humans; Membrane Glycoproteins; Naltrexone; Narcotic Antagonists; Neoplasm Invasiveness; Neoplasms; Opioid Peptides | 2007 |
Tolerance to repeated morphine administration is associated with increased potency of opioid agonists.
Topics: Analgesics, Opioid; Animals; Brain Chemistry; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Tolerance; Enkephalin, Methionine; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Male; Morphine Dependence; Naltrexone; Narcotic Antagonists; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, mu | 2008 |
YFa, a chimeric opioid peptide, induces kappa-specific antinociception with no tolerance development during 6 days of chronic treatment.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, Methionine; FMRFamide; Gene Expression Regulation; Male; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain Measurement; Rats; Rats, Wistar; Reaction Time; Receptors, Opioid, kappa; Receptors, Opioid, mu; Time Factors | 2008 |
Methionine-enkephalin modulation of hydrogen peroxide (H2O2) release by rat peritoneal macrophages involves different types of opioid receptors.
Topics: Animals; Benzylidene Compounds; Carcinogens; Dose-Response Relationship, Drug; Enkephalin, Methionine; Hydrogen Peroxide; Macrophages, Peritoneal; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tetradecanoylphorbol Acetate | 2008 |
Presynaptic actions of opioid receptor agonists in ventromedial hypothalamic neurons in estrogen- and oil-treated female mice.
Topics: Analgesics, Opioid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Estradiol; Estrogens; Excitatory Postsynaptic Potentials; Female; In Vitro Techniques; Mice; Naltrexone; Narcotic Antagonists; Neural Inhibition; Neurons; Oils; Ovariectomy; Patch-Clamp Techniques; Presynaptic Terminals; Ventromedial Hypothalamic Nucleus | 2008 |
A prolonged nitric oxide-dependent, opioid-mediated antinociceptive effect of hyperbaric oxygen in mice.
Topics: Acetic Acid; Analgesia; Analysis of Variance; Animals; beta-Endorphin; Citrulline; Dynorphins; Enkephalin, Methionine; Enzyme Inhibitors; Hyperbaric Oxygenation; Injections, Intraperitoneal; Male; Mice; Microinjections; Naltrexone; Narcotic Antagonists; Neurotransmitter Agents; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pain; Pain Measurement; Thiourea | 2009 |
Cell proliferation of human ovarian cancer is regulated by the opioid growth factor-opioid growth factor receptor axis.
Topics: Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinase Inhibitor p21; DNA Replication; Down-Regulation; Enkephalin, Methionine; Female; Humans; Naltrexone; Narcotic Antagonists; Ovarian Neoplasms; Receptors, Opioid; RNA Interference; RNA, Small Interfering; Signal Transduction; Time Factors | 2009 |
Buprenorphine is a weak partial agonist that inhibits opioid receptor desensitization.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Biophysics; Brain; Brimonidine Tartrate; Buprenorphine; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Methionine; In Vitro Techniques; Male; Membrane Potentials; Mice; Mice, Transgenic; Naltrexone; Narcotic Antagonists; Narcotics; Neural Inhibition; Neurons; Patch-Clamp Techniques; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Yohimbine | 2009 |
Opioid growth factor-opioid growth factor receptor axis is a physiological determinant of cell proliferation in diverse human cancers.
Topics: Cell Line, Tumor; Cell Proliferation; Enkephalin, Methionine; Gene Expression Regulation, Neoplastic; Humans; Naltrexone; Narcotic Antagonists; Neoplasms; Receptors, Opioid; RNA Interference; RNA, Messenger; Signal Transduction | 2009 |
Topical application of naltrexone facilitates reepithelialization of the cornea in diabetic rabbits.
Topics: Analysis of Variance; Animals; Blood Glucose; Body Weight; Corneal Diseases; Diabetes Complications; Disease Models, Animal; Enkephalin, Methionine; Epithelium, Corneal; Intraocular Pressure; Male; Naltrexone; Narcotic Antagonists; Rabbits; Regeneration; Time Factors | 2010 |
Tolerance to the antinociceptive effect of morphine in the absence of short-term presynaptic desensitization in rat periaqueductal gray neurons.
Topics: Analgesics; Animals; Drug Tolerance; Electrophysiological Phenomena; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Inhibitory Postsynaptic Potentials; Male; Morphine; Naltrexone; Neurons; Pain Measurement; Patch-Clamp Techniques; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid, mu; Signal Transduction | 2010 |
T lymphocyte proliferation is suppressed by the opioid growth factor ([Met(5)]-enkephalin)-opioid growth factor receptor axis: implication for the treatment of autoimmune diseases.
Topics: Animals; Autoimmune Diseases; Cell Proliferation; Cells, Cultured; Enkephalin, Methionine; Immunosuppression Therapy; Male; Mice; Mice, Inbred C57BL; Naltrexone; Receptors, Opioid; RNA, Small Interfering; T-Lymphocytes | 2011 |
Prevention and diminished expression of experimental autoimmune encephalomyelitis by low dose naltrexone (LDN) or opioid growth factor (OGF) for an extended period: Therapeutic implications for multiple sclerosis.
Topics: Analysis of Variance; Animals; Astrocytes; Chi-Square Distribution; Encephalomyelitis, Autoimmune, Experimental; Enkephalin, Methionine; Female; Mice; Mice, Inbred C57BL; Myelin Proteins; Myelin Sheath; Myelin-Associated Glycoprotein; Myelin-Oligodendrocyte Glycoprotein; Naltrexone; Neurons | 2011 |
Regular exercise reverses sensory hypersensitivity in a rat neuropathic pain model: role of endogenous opioids.
Topics: Animals; beta-Endorphin; Brain Stem; Disease Models, Animal; Enkephalin, Methionine; Male; Naltrexone; Narcotic Antagonists; Neuralgia; Pain Threshold; Physical Conditioning, Animal; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Opioid | 2011 |
The opioid growth factor (OGF) and low dose naltrexone (LDN) suppress human ovarian cancer progression in mice.
Topics: Animals; Apoptosis; Cell Line, Tumor; Disease Progression; DNA; Enkephalin, Methionine; Female; Humans; Mice; Mice, Nude; Naltrexone; Narcotic Antagonists; Neovascularization, Pathologic; Ovarian Neoplasms; Receptors, Opioid; Xenograft Model Antitumor Assays | 2011 |
The action of a synthetic derivative of Met5-enkephalin-Arg6-Phe7 on behavioral and endocrine responses.
Topics: Animals; Behavior, Animal; Enkephalin, Methionine; Enkephalins; Hypothalamo-Hypophyseal System; Male; Mice; Mice, Inbred Strains; Naloxone; Naltrexone; Oligopeptides; Pituitary-Adrenal System | 2011 |
YFa and analogs: investigation of opioid receptors in smooth muscle contraction.
Topics: Acetylcholine; Analgesics, Opioid; Animals; Cholinergic Agonists; Dynorphins; Enkephalin, Methionine; Guinea Pigs; Ileum; Male; Mice; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists; Neurotransmitter Agents; Oligopeptides; Receptors, Opioid; Vas Deferens | 2011 |
The opioid growth factor-opioid growth factor receptor axis: homeostatic regulator of cell proliferation and its implications for health and disease.
Topics: Animals; Antineoplastic Agents; Autoimmune Diseases; Cell Cycle; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinase Inhibitor p21; Diabetes Complications; Enkephalin, Methionine; Epithelium; Homeostasis; Humans; Lymphocytes; Naltrexone; Narcotic Antagonists; Neoplasms; Receptors, Opioid; Wound Healing | 2012 |
Involvement of spinal cord opioid mechanisms in the acute antinociceptive effect of hyperbaric oxygen in mice.
Topics: Acetic Acid; Analgesia; Animals; beta-Endorphin; Dynorphins; Enkephalin, Methionine; Hyperbaric Oxygenation; Injections, Spinal; Male; Mice; Naltrexone; Narcotic Antagonists; Spinal Cord | 2013 |
The immunomodulation mediated by a delta-opioid receptor for [Met(5)]-enkephalin in oyster Crassostrea gigas.
Topics: Amino Acid Sequence; Animals; Benzylidene Compounds; Calcium; Cell Line; Cloning, Molecular; Crassostrea; Cyclic AMP; DNA, Complementary; Enkephalin, Methionine; HEK293 Cells; Hepatopancreas; Humans; Lipopolysaccharides; Molecular Sequence Data; Naltrexone; Phagocytosis; Receptors, Opioid, delta; RNA, Messenger; Sequence Alignment; Signal Transduction; Vibrio | 2015 |
Opioid growth factor and low-dose naltrexone impair central nervous system infiltration by CD4 + T lymphocytes in established experimental autoimmune encephalomyelitis, a model of multiple sclerosis.
Topics: Animals; CD4-Positive T-Lymphocytes; Central Nervous System; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Enkephalin, Methionine; Female; Mice; Multiple Sclerosis; Naltrexone; Narcotic Antagonists | 2016 |
δ-Opioid receptors: Pivotal role in intermittent hypoxia-augmentation of cardiac parasympathetic control and plasticity.
Topics: Animals; Dogs; Enkephalin, Methionine; Heart Atria; Hypoxia; Microdialysis; Naltrexone; Narcotic Antagonists; Neuronal Plasticity; Norepinephrine; Receptors, Opioid, delta; Sinoatrial Node; Vagus Nerve | 2016 |
Ultraviolet A eye irradiation ameliorates colon carcinoma induced by azoxymethane and dextran sodium sulfate through β-endorphin and methionine-enkephalin.
Topics: Aminoquinolines; Animals; Azoxymethane; Benzamides; beta-Endorphin; Colon; Colonic Neoplasms; Dextran Sulfate; Enkephalin, Methionine; Eye; Female; Interleukin-6; Ki-67 Antigen; Mice, Inbred ICR; Naltrexone; Receptors, Opioid; Receptors, Opioid, mu; Tumor Necrosis Factor-alpha; Ultraviolet Rays | 2017 |
Characterization of functional μ opioid receptor turnover in rat locus coeruleus: an electrophysiological and immunocytochemical study.
Topics: Analgesics, Opioid; Animals; Electrophysiological Phenomena; Enkephalin, Methionine; Locus Coeruleus; Male; Naltrexone; Narcotic Antagonists; Neurons; Rats, Sprague-Dawley; Receptors, Opioid, mu | 2017 |
Featured Article: Serum [Met
Topics: Adult; Aged; Aged, 80 and over; Animals; Biomarkers; Encephalomyelitis, Autoimmune, Experimental; Enkephalin, Methionine; Female; Humans; Male; Mice, Inbred C57BL; Middle Aged; Multiple Sclerosis; Naltrexone; Neuroprotective Agents; Serum; Treatment Outcome; Volunteers; Young Adult | 2017 |
Killing effect of methionine enkephalin on melanoma in vivo and in vitro.
Topics: Animals; Cell Cycle Checkpoints; Cell Proliferation; Dendritic Cells; Enkephalin, Methionine; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; Interferon-gamma; Interleukin-2; Melanoma, Experimental; Mice; Naltrexone; Tumor Burden; Tumor Necrosis Factor-alpha | 2017 |
Featured Article: Modulation of the OGF-OGFr pathway alters cytokine profiles in experimental autoimmune encephalomyelitis and multiple sclerosis.
Topics: Adult; Aged; Aged, 80 and over; Animals; Cytokines; Encephalomyelitis, Autoimmune, Experimental; Enkephalin, Methionine; Female; Glatiramer Acetate; Humans; Immunosuppressive Agents; Male; Mice, Inbred C57BL; Middle Aged; Multiple Sclerosis; Naltrexone; Receptors, Opioid | 2018 |
The Chemokine CCL4 (MIP-1β) Evokes Antinociceptive Effects in Mice: a Role for CD4
Topics: Analgesics; Animals; CD4-Positive T-Lymphocytes; Chemokine CCL4; Enkephalin, Methionine; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Nociception; Pain; Pain Measurement | 2019 |
The effect of naltrexone as a carboplatin chemotherapy-associated drug on the immune response, quality of life and survival of dogs with mammary carcinoma.
Topics: Animals; beta-Endorphin; Carboplatin; Dogs; Drug Synergism; Enkephalin, Methionine; Female; Immunophenotyping; Lymphocytes; Mammary Neoplasms, Animal; Mastectomy; Naltrexone; Neoplasm Metastasis; Quality of Life; Survival Analysis; Treatment Outcome | 2018 |
Systemic administration of low-dose naltrexone increases bone mass due to blockade of opioid growth factor receptor signaling in mice osteoblasts.
Topics: Animals; Bone Density; Cell Proliferation; Cells, Cultured; Enkephalin, Methionine; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Neurotransmitter Agents; Osteoblasts; Receptors, Opioid | 2019 |
Blockade of OGFr delays the onset and reduces the severity of diabetic ocular surface complications.
Topics: Animals; Blood Glucose; Body Weight; Cornea; Diabetes Complications; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Enkephalin, Methionine; Eye; Male; Naltrexone; Rats, Sprague-Dawley; Receptors, Opioid; Severity of Illness Index; Time Factors | 2021 |
Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors.
Topics: Analgesics; Animals; Binding Sites; Cell Line; CHO Cells; Cloning, Molecular; Cricetinae; Ligands; PC12 Cells; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Software | 1994 |
Cloning and functional comparison of kappa and delta opioid receptors from mouse brain.
Topics: Amino Acid Sequence; Animals; Base Sequence; Brain Chemistry; Cloning, Molecular; In Situ Hybridization; Mice; Molecular Sequence Data; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Somatostatin; RNA, Messenger; Sequence Homology, Amino Acid; Substrate Specificity; Tissue Distribution | 1993 |