naltrexone has been researched along with enkephalin, leucine-2-alanine in 144 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 48 (33.33) | 18.7374 |
| 1990's | 60 (41.67) | 18.2507 |
| 2000's | 31 (21.53) | 29.6817 |
| 2010's | 5 (3.47) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bell, GI; Chen, Y; Kong, H; Raynor, K; Reisine, T; Yasuda, K; Yu, L | 1 |
| Adapa, ID; Auh, JS; Berzetei-Gurske, IP; Brandt, SR; Craymer, K; Farrington, L; Haggart, D; Kennedy, JM; O'Brien, A; Polgar, WE; Rodriguez, L; Schwartz, RW; Toll, L; White, A | 1 |
| Bowen, WD; Farmer, SC; Mattia, A; Mosberg, HI; Porreca, F; Portoghese, PS; Sultana, M; Takemori, AE | 1 |
| Kameyama, T; Toyoshi, T; Ukai, M | 1 |
| Kane, K; McIntosh, M; Parratt, J | 1 |
| Portoghese, PS; Sofuoglu, M; Takemori, AE | 1 |
| Malmberg, AB; Yaksh, TL | 1 |
| Barg, J; Belcheva, MM; Chuang, DM; Coscia, CJ; Gao, XM; Gloeckner, C | 1 |
| Bowen, WD; Jiang, Q; Mosberg, HI; Porreca, F; Portoghese, PS; Sultana, M; Takemori, AE | 1 |
| Chang, SC; Lutfy, K; Sierra, V; Yoburn, BC | 1 |
| Bykov, V; de Costa, BR; Holaday, JW; Jacobson, AE; Jiang, Q; Long, JB; Mahboubi, A; Porreca, F; Rice, KC; Rothman, RB | 1 |
| Barg, J; Belcheva, MM; Chuang, DM; Coscia, CJ; Gao, XM; McHale, RJ | 1 |
| Arjune, D; Bodnar, RJ; Bowen, WD | 1 |
| Bykov, V; Holaday, JW; Jacobson, AE; Long, JB; Rice, KC; Rothman, RB | 2 |
| Allen, JT; Brostrom, PA; DeHaven-Hudkins, DL; Ferkany, JW; Kaplita, PV; Lesko, LJ; Mavunkel, BJ; Rzeszotarski, WJ; Steranka, LR | 1 |
| Chalmers, J; Drolet, G; Morilak, DA | 1 |
| LoPresti, D; Porreca, F; Ward, SJ | 1 |
| Chalmers, J; Drolet, G; Morilak, D | 1 |
| Fuentes, JA; Iglesias, T; Jiménez, I | 1 |
| Lutfy, K; Sierra, V; Yoburn, BC | 2 |
| Goodman, RR; Hahn, EF; Nishimura, S; Pasternak, GW | 1 |
| Galetta, S; Hahn, EF; Nishimura, S; Pasternak, GW | 1 |
| Gonzalez, JP; Sewell, RD; Smith, HJ; Williams, PS | 1 |
| McLaughlin, PJ; Zagon, IS | 2 |
| Garzón, J; Sánchez-Blázquez, P | 1 |
| Garzón, J; Sánchez-Blázquez, P; Ulibarri, I | 1 |
| Pasternak, GW; Recht, LD | 1 |
| Smith, CB | 1 |
| Larson, DL; Lipkowski, AW; Nagase, H; Portoghese, PS; Takemori, AE | 1 |
| Bhargava, HN; Rapaka, RS; Renugopalakrishnan, V | 1 |
| Nagase, H; Portoghese, PS; Takemori, AE | 1 |
| Ho, BY; Naeseth, JS; Portoghese, PS; Takemori, AE | 1 |
| Inturrisi, CE; Luke, MC; Pasternak, GW; Yoburn, BC | 1 |
| Costa, T; Herz, A; Klinz, FJ; Vachon, L | 1 |
| Lipkowski, AW; Portoghese, PS; Takemori, AE | 1 |
| Portoghese, PS; Takemori, AE | 3 |
| Cohen, AH; Goodman, RR; Inturrisi, CE; Pasternak, GW; Yoburn, BC | 1 |
| Holaday, JW; Robles, L; Tortella, FC | 1 |
| Jackson, HC; Sewell, RD | 1 |
| Bell, RD; Cicero, TJ | 1 |
| Coscia, CJ; Devane, WA; Howlett, AC; Spain, JW | 1 |
| Holtzman, SG; Locke, KW | 2 |
| Adler, B; Inturrisi, CE; Nunes, FA; Pasternak, GW; Yoburn, BC | 1 |
| Liu-Chen, LY; Tam, SW | 1 |
| Mosberg, HI; Robles, L; Tortella, FC | 1 |
| Carter, A; Smith, CF | 1 |
| Portoghese, PS; Schoenecker, JW; Takemori, AE | 1 |
| Coscia, CJ; Spain, JW | 1 |
| Bruzzone, ME; Marusic, ET | 1 |
| Haddad, GG; Jeng, HJ; Lai, TL | 1 |
| Pert, CB; Rothman, RB; Schumacher, UK | 1 |
| Cicero, TJ; Isenberg, KE | 1 |
| Holaday, JW; Tortella, FC | 1 |
| Bernardini, GL; Clark, WG; Pang, IH | 1 |
| Takemori, AE; Ward, SJ | 2 |
| Chavkin, C; Cox, BM | 1 |
| Herz, A; Schulz, R; Wüster, M | 1 |
| Kosterlitz, HW; Paterson, SJ; Robson, LE | 1 |
| Fitz-Syage, ML; Gardner, EL; Gintzler, AR; Sugarman, JR; Zukin, RS; Zukin, SR | 1 |
| Cowan, A; Holaday, JW; Robles, LE; Tortella, FC | 1 |
| Castellano, C; Csányl, V; Dóka, A; Oliverio, A; Puglisi-Allegra, S | 1 |
| Bodnar, RJ; Cole, JL; Kirkham, TC; Leventhal, L | 1 |
| Kushner, L; Tamir, M | 1 |
| Bodnar, RJ; Glass, MJ; Koch, JE | 1 |
| Coupar, IM; Hancock, DL | 1 |
| Bodnar, RJ; Glass, MJ; Hahn, B; Joseph, A | 1 |
| Ingenito, AJ; Wong, SC | 1 |
| Rafferty, MF; Tam, L | 1 |
| Bowen, WD; Miyamoto, Y; Portoghese, PS; Takemori, AE | 1 |
| Giagnoni, G; Massi, P; Parolaro, D; Patrini, G; Rubino, T; Venier, I | 1 |
| Haaseth, RC; Hruby, VJ; Matsunaga, TO; Mosberg, HI; Porreca, F; Portoghese, PS; Sultana, M; Takemori, AE; Vanderah, T | 1 |
| Brusa, L; D'Amore, A; Lorenzini, P; Massotti, M | 1 |
| Bodnar, RJ; Hahn, B; Koch, JE; Ruegg, H | 1 |
| Hua, M; Larson, DL; Portoghese, PS; Takemori, AE | 1 |
| Bowen, WD; Holtzman, SG; Jones, DN; Portoghese, PS | 1 |
| DeHaven-Hudkins, DL; Komer, KM; Mavunkel, BJ; Peterson, JA; Rzeszotarski, WJ | 1 |
| Bowen, WD; Carlisi, VJ; Hruby, VJ; Mosberg, HI; Porreca, F; Portoghese, PS; Sultana, M; Takemori, AE; Wild, KD | 1 |
| Bodnar, RJ; Koch, JE | 1 |
| Tiseo, PJ; Yaksh, TL | 1 |
| Beczkowska, IW; Bodnar, RJ; Bostock, ME; Koch, JE; Leibowitz, SF | 1 |
| Magyar, A; Medzihradszky, K; Rónai, AZ | 1 |
| Aramaki, T; Inoki, R; Maeda, S; Ohnishi, T; Ooi, Y; Saito, K; Shinno, E | 1 |
| Olianas, MC; Onali, P | 1 |
| Heagy, W; Shahabi, NA; Sharp, BM | 1 |
| Casares, F; Liu, U; Stefano, GB | 1 |
| Bodnar, RJ; Leventhal, L | 1 |
| Rothe, KS; Stevens, CW | 1 |
| Bodnar, RJ; Ragnauth, A; Ruegg, H | 1 |
| Artico, M; Clarke, GD; Dondio, G; Eggleston, DS; Farina, C; Petrillo, P; Petrone, G; Ronzoni, S; Vecchietti, V; Visentin, L | 1 |
| Belcheva, MM; Coscia, CJ; Lissichkova, EG; Tencheva, ZS; Velichkova, AA | 1 |
| Stevens, CW; Willenbring, S | 1 |
| Blake, AD; Bot, G; Li, S; Reisine, T | 1 |
| Kragballe, K; Nissen, JB | 1 |
| Adams, DJ; Trequattrini, C | 1 |
| Elde, R; Kshirsagar, T; Law, PY; Nakano, AH; Portoghese, PS | 1 |
| Andrews, AM; Cadet, JL; Chiueh, CC; Ladenheim, B; Su, TP; Tsao, LI | 1 |
| Belcheva, MM; Bohn, LM; Coscia, CJ; Ignatova, EG; Neuman, MC | 1 |
| Dersch, C; Kubota, H; McCullough, K; Pinto, J; Rice, KC; Rothman, RB | 1 |
| Befort, K; Filliol, D; Kieffer, BL; Yue, S; Zilliox, C | 1 |
| Maslov, LN; Naryzhnaya, NV; Tam, SW | 1 |
| Ananthan, S; Bilsky, EJ; Carter, RL; Davis, P; Dersch, CM; Kezar, HS; Porreca, F; Rice, KC; Rothman, RB; Saini, SK; Wells, JL; Xu, H | 1 |
| Fournel, S; Nano, JL; Rampal, P | 1 |
| Gyires, K; Müllner, K; Rónai, AZ | 1 |
| Ostermeier, AM; Schlösser, B; Schwender, D; Sutor, B | 1 |
| Bilfinger, TV; Magazine, HI; Murga, JD; Qi, F; Saeed, RW; Short, TW; Stefano, GB | 1 |
| Haddad, GG; Xia, Y; Zhang, J | 1 |
| Bolling, SF; Bowden, K; Claycomb, WC; Kenyon, E; Kovach, MA; Neilan, CL; Traynor, JR | 1 |
| Fryer, RM; Gross, GJ; Hsu, AK; Wang, Y | 1 |
| Bahia, DS; Cavalli, A; Hoffmann, M; Massotte, D; Milligan, G; Moon, HE | 1 |
| Dermitzaki, E; Gravanis, A; Margioris, AN; Stournaras, C; Venihaki, M | 1 |
| Li, P; Longhurst, JC; Tjen-A-Looi, S | 1 |
| Bahia, DS; Cavalli, A; Hoffmann, M; Milligan, G; Moon, HE | 1 |
| Deschamps, JR; Flippen-Anderson, JL; George, C; Hruby, VJ; Lipkowski, AW; Misicka, A | 1 |
| Gibney, GT; Xia, Y; Zhang, J; Zhao, P | 1 |
| Auerbach, SB; Tao, R | 1 |
| Coles, JA; Iaizzo, PA; Sigg, DC | 1 |
| McAllen, K; Shahabi, NA; Sharp, BM | 1 |
| Bolling, SF; Claycomb, WC; Kovach, MA; Romano, MA; Seymour, EM; Traynor, JR; Wu, SY | 1 |
| Law, PY; Loh, HH; Portoghese, PS | 1 |
| Bernardi, G; D'Angelo, V; Lavaroni, F; Martella, G; Martorana, A; Spadoni, F; Stefani, A | 1 |
| Esquilin, M; Gibney, GT; Hong, SS; Xia, Y; Yu, J | 1 |
| Bespalova, ZhD; Lasukova, TV; Maslov, LN; Nagase, H; Oldgen, P; Rice, KK | 1 |
| Coupar, IM; Gray, AC; White, PJ | 1 |
| Hong, SS; Qian, H; Xia, Y; Zhang, J; Zhao, P | 1 |
| Bazzy-Asaad, A; Chao, D; Donnelly, DF; Feng, Y; Xia, Y | 1 |
| Su, DS; Wang, XR; Wang, ZH; Zhao, YH; Zheng, YJ | 1 |
| Furuya, H; Inoue, S; Iwata, M; Kawaguchi, M; Konishi, N; Nakamura, M | 1 |
| Su, RJ; Su, YH; Wang, HX; Wong, TM; Yang, J; Zhao, M | 1 |
| Huang, FS; Tang, JS; Wang, JY; Yuan, YK; Zhao, M | 1 |
| Guo, JC; Li, MW; Ou, XM; Tian, XS; Zhu, CQ; Zhu, M | 1 |
| Kolar, F; Krylatov, AV; Lishmanov, YB; Maslov, LN; Naryzhnaya, NV; Ovchinnikov, MV; Stakheev, DL | 1 |
| Dian-san, S; Ke, S; Xiang-rui, W | 1 |
| Freed, WJ; Hayashi, T; Lee, CT; Su, TP; Tsai, SY | 1 |
| Ma, L; Pei, G; Teng, L; Wang, F; Zhao, J | 1 |
| Chai, W; Gao, CJ; Li, JP; Li, YQ; Lü, BC; Niu, L; Wang, W; Wei, YY; Wu, SX; Zhang, T; Zhu, C | 1 |
| Du, J; Liang, R; Tang, B; Wang, H; Wang, L; Yuan, P; Zhang, Y | 1 |
| DU, J; Gao, ZM; Jin, XL; Liang, R; Sun, DG; Tang, B; Wang, LM | 1 |
144 other study(ies) available for naltrexone and enkephalin, leucine-2-alanine
| Article | Year |
|---|---|
Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors.
Topics: Analgesics; Animals; Binding Sites; Cell Line; CHO Cells; Cloning, Molecular; Cricetinae; Ligands; PC12 Cells; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Software | 1994 |
Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications.
Topics: Animals; Aorta, Thoracic; Cocaine; Cyclic AMP; Electric Stimulation; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Mice; Muscle, Smooth; Opioid-Related Disorders; Rats; Receptors, Dopamine; Receptors, Opioid; Receptors, Serotonin; Substance-Related Disorders | 1998 |
Spinal opioid delta antinociception in the mouse: mediation by a 5'-NTII-sensitive delta receptor subtype.
Topics: Affinity Labels; Analgesics; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Isothiocyanates; Male; Mice; Mice, Inbred ICR; Morphinans; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain Measurement; Receptors, Opioid, delta; Spinal Cord; Thiocyanates | 1992 |
Effects of [D-Ala2, D-Leu5]enkephalin and [D-Pen2, L-Pen5]enkephalin on apomorphine-induced motor activity in the mouse.
Topics: Analgesics; Animals; Apomorphine; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Grooming; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Motor Activity; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Stereotyped Behavior | 1992 |
Effects of selective opioid receptor agonists and antagonists during myocardial ischaemia.
Topics: Animals; Arrhythmias, Cardiac; Coronary Disease; Coronary Vessels; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Hemodynamics; Male; Morphinans; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1992 |
delta-Opioid receptor binding in mouse brain: evidence for heterogeneous binding sites.
Topics: Animals; Binding, Competitive; Brain Chemistry; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Membranes; Mice; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta | 1992 |
Isobolographic and dose-response analyses of the interaction between intrathecal mu and delta agonists: effects of naltrindole and its benzofuran analog (NTB).
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Indoles; Injections, Spinal; Male; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu | 1992 |
Antagonist-induced transient down-regulation of delta-opioid receptors in NG108-15 cells.
Topics: Amino Acid Sequence; Binding Sites; Binding, Competitive; Concanavalin A; Down-Regulation; Enkephalin, Leucine-2-Alanine; Glioma; Kinetics; Lysosomes; Molecular Sequence Data; Naloxone; Naltrexone; Narcotic Antagonists; Neuroblastoma; Receptors, Opioid; Receptors, Opioid, delta; Subcellular Fractions; Tritium; Tumor Cells, Cultured | 1992 |
Differential antagonism of opioid delta antinociception by [D-Ala2,Leu5,Cys6]enkephalin and naltrindole 5'-isothiocyanate: evidence for delta receptor subtypes.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Injections, Intraventricular; Isothiocyanates; Male; Mice; Mice, Inbred ICR; Morphinans; Naltrexone; Narcotic Antagonists; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta; Thiocyanates | 1991 |
Dissociation of opioid receptor upregulation and functional supersensitivity.
Topics: Analgesia; Animals; Binding Sites; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Kinetics; Male; Mice; Morphine; Naltrexone; Pertussis Toxin; Receptors, Opioid; Up-Regulation; Virulence Factors, Bordetella | 1991 |
Interaction of beta-funaltrexamine with [3H]cycloFOXY binding in rat brain: further evidence that beta-FNA alkylates the opioid receptor complex.
Topics: Alkylating Agents; Alkylation; Analgesics; Animals; Brain; Enkephalin, Leucine-2-Alanine; Injections, Intraventricular; Kinetics; Ligands; Male; Mice; Mice, Inbred ICR; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Surface Properties | 1991 |
Up-regulation of delta opioid receptors in neuroblastoma hybrid cells: evidence for differences in the mechanisms of action of sodium butyrate and naltrexone.
Topics: Binding Sites; Butyrates; Butyric Acid; Cycloheximide; Diprenorphine; Enkephalin, Leucine-2-Alanine; Hybrid Cells; Naltrexone; Neuroblastoma; Receptors, Opioid; Receptors, Opioid, delta; Tumor Cells, Cultured; Up-Regulation | 1991 |
Ingestive behavior following central [D-Ala2, Leu5, Cys6]-enkephalin (DALCE), a short-acting agonist and long-acting antagonist at the delta opioid receptor.
Topics: Animals; Deoxyglucose; Diet; Dietary Fats; Dose-Response Relationship, Drug; Enkephalin, Leucine-2-Alanine; Feeding Behavior; Food Deprivation; Glucose; Injections, Intraventricular; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid, delta | 1991 |
Pretreatment of rats with the irreversible mu-receptor antagonist, beta-FNA, fails to prevent naltrexone-induced upregulation of mu-opioid receptors.
Topics: Animals; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; In Vitro Techniques; Isothiocyanates; Kinetics; Naltrexone; Narcotic Antagonists; Oxymorphone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Thiocyanates; Up-Regulation | 1990 |
Pharmacologic profile of NPC 168 (naltrexone phenyl oxime), a novel compound with activity at opioid receptors.
Topics: Animals; Binding, Competitive; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Food Deprivation; Guinea Pigs; Injections, Intraventricular; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Reaction Time; Reinforcement Schedule | 1990 |
Tonic opioid inhibition of the pressor region of the rostral ventrolateral medulla of rabbits is mediated by delta receptors.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Glutamates; Glutamic Acid; Hemodynamics; Male; Medulla Oblongata; Microinjections; Naltrexone; Narcotic Antagonists; Pressoreceptors; Rabbits; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1990 |
Opioid agonist affinity in the guinea-pig ileum and mouse vas deferens.
Topics: Animals; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Guinea Pigs; Ileum; Male; Methadone; Mice; Morphine; Morphine Derivatives; Naltrexone; Receptors, Opioid; Vas Deferens | 1990 |
A lack of potency for the delta-opioid antagonist naltrindole after microinjection into the rostral ventrolateral medulla of rabbits.
Topics: Animals; Blood Pressure; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Indoles; Male; Medulla Oblongata; Microinjections; Morphinans; Naltrexone; Narcotic Antagonists; Rabbits; Receptors, Opioid; Receptors, Opioid, delta | 1990 |
Stereoselectivity and subtype of the opiate receptor involved in stress-induced hypertension.
Topics: Animals; Blood Pressure; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Hypertension; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Social Isolation; Stereoisomerism; Stress, Psychological | 1990 |
Simultaneous development of opioid tolerance and opioid antagonist-induced receptor upregulation.
Topics: Analgesia; Animals; Brain; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Kinetics; Male; Mice; Morphine; Naloxone; Naltrexone; Pain; Receptors, Opioid; Reference Values; Up-Regulation | 1990 |
Irreversible opiate agonists and antagonists. II. Evidence against a bivalent mechanism of action for opiate azines and diacylhydrazones.
Topics: Animals; Binding, Competitive; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hydromorphone; In Vitro Techniques; Male; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Oxymorphone; Rats; Rats, Inbred Strains; Receptors, Opioid; Structure-Activity Relationship | 1985 |
Oxymorphone-naltrexonazine, a mixed opiate agonist-antagonist.
Topics: Analgesia; Animals; Binding, Competitive; Brain; Dihydromorphine; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hydromorphone; Male; Mice; Mice, Inbred ICR; Naltrexone; Oxymorphone; Rats; Rats, Inbred Strains; Receptors, Opioid; Sodium | 1987 |
Novel inhibitors of enkephalin-degrading enzymes. I: Inhibitors of enkephalinase by penicillins.
Topics: Analgesics; Animals; Brain; Enkephalin, Leucine-2-Alanine; Isoenzymes; Male; Mice; Mice, Inbred Strains; Naltrexone; Neprilysin; Pain; Penicillins; Thiorphan; Time Factors | 1989 |
Opioid antagonist modulation of murine neuroblastoma: a profile of cell proliferation and opioid peptides and receptors.
Topics: Animals; Cell Division; Cell Line; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Mice; Naltrexone; Neoplasms, Experimental; Neuroblastoma; Receptors, Opioid | 1989 |
Chronic opioid antagonist treatment: assessment of receptor upregulation.
Topics: Animals; Binding, Competitive; Brain Chemistry; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Kinetics; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Up-Regulation | 1989 |
Evaluation of delta receptor mediation of supraspinal opioid analgesia by in vivo protection against the beta-funaltrexamine antagonist effect.
Topics: Analgesics, Opioid; Animals; Brain Chemistry; Dihydromorphine; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; In Vitro Techniques; Injections, Intraventricular; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Pain Measurement; Receptors, Opioid; Receptors, Opioid, delta | 1989 |
Intracerebroventricular N-ethylmaleimide differentially reduces supraspinal opioid analgesia in mice.
Topics: Analgesics; Animals; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylmaleimide; Injections, Intraventricular; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Sulfhydryl Reagents | 1989 |
Effects of beta-funaltrexamine on radiolabeled opioid binding.
Topics: Animals; Binding, Competitive; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; In Vitro Techniques; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu | 1987 |
New approaches to the evaluation of opioid agonists and antagonists upon the isolated, electrically stimulated mouse vas deferens preparation.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Benzomorphans; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Oligopeptides; Pyrrolidines; Receptors, Opioid; Vas Deferens | 1987 |
Binaltorphimine-related bivalent ligands and their kappa opioid receptor antagonist selectivity.
Topics: Animals; Chemical Phenomena; Chemistry; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Male; Mice; Models, Molecular; Morphine; Muscle, Smooth; Naltrexone; Receptors, Opioid; Receptors, Opioid, kappa; Structure-Activity Relationship | 1988 |
Effect of ethanol on the binding of conformationally rigid and labile ligands of opioid receptors to rat brain membranes.
Topics: Animals; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethanol; In Vitro Techniques; Male; Naltrexone; Oligopeptides; Protein Conformation; Rats; Rats, Inbred Strains; Receptors, Opioid | 1988 |
Only one pharmacophore is required for the kappa opioid antagonist selectivity of norbinaltorphimine.
Topics: Animals; Chemical Phenomena; Chemistry; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Ileum; Male; Mice; Morphine; Naltrexone; Receptors, Opioid; Receptors, Opioid, kappa; Stereoisomerism; Structure-Activity Relationship; Vas Deferens | 1988 |
Nor-binaltorphimine, a highly selective kappa-opioid antagonist in analgesic and receptor binding assays.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Guinea Pigs; Male; Mice; Morphine; Naltrexone; Oligopeptides; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa | 1988 |
Upregulation of opioid receptor subtypes correlates with potency changes of morphine and DADLE.
Topics: Animals; Brain; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Mice; Morphine; Naltrexone; Pain; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1988 |
beta-FNA binds irreversibly to the opiate receptor complex: in vivo and in vitro evidence.
Topics: Animals; Binding Sites; Binding, Competitive; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Injections, Intraventricular; Male; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1988 |
Opioid receptors are coupled tightly to G proteins but loosely to adenylate cyclase in NG108-15 cell membranes.
Topics: Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Cyclic AMP; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enzyme Activation; GTP Phosphohydrolases; GTP-Binding Proteins; Naltrexone; Pertussis Toxin; Protein Binding; Receptors, Opioid; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1988 |
Binaltorphimine and nor-binaltorphimine, potent and selective kappa-opioid receptor antagonists.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Chemical Phenomena; Chemistry; Cyclazocine; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Male; Mice; Morphine; Naloxone; Naltrexone; Pyrrolidines; Rabbits; Receptors, Opioid; Receptors, Opioid, kappa | 1987 |
TENA, a selective kappa opioid receptor antagonist.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Azocines; Benzomorphans; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Ileum; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vas Deferens | 1985 |
Increased analgesic potency of morphine and increased brain opioid binding sites in the rat following chronic naltrexone treatment.
Topics: Animals; Binding, Competitive; Brain; Drug Implants; Drug Interactions; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Morphine; Naloxone; Naltrexone; Pain; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Opioid; Time Factors | 1985 |
The anticonvulsant effects of DADLE are primarily mediated by activation of delta opioid receptors: interactions between delta and mu receptor antagonists.
Topics: Animals; Anticonvulsants; Cerebral Ventricles; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Seizures | 1985 |
Receptors for opioid peptides in the guinea-pig ileum.
Topics: Alkylation; Animals; Dose-Response Relationship, Drug; Electric Stimulation; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Ileum; Male; Mice; Naloxone; Naltrexone; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Vas Deferens | 1985 |
Are delta-opioid receptors involved in the regulation of food and water intake?
Topics: Animals; Benzomorphans; Drinking Behavior; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Feeding Behavior; Injections, Intraperitoneal; Injections, Intraventricular; Male; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta | 1985 |
A radiolabeled-ligand-binding technique for the characterization of opioid receptors in the intact mouse vas deferens.
Topics: Animals; Binding, Competitive; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; In Vitro Techniques; Kinetics; Male; Mice; Morphine; Naltrexone; Radioligand Assay; Receptors, Opioid; Vas Deferens | 1985 |
An assessment of the role of opioid receptors in the response to cannabimimetic drugs.
Topics: Adenylyl Cyclase Inhibitors; Animals; Cannabinoids; Cell Line; Dronabinol; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Etorphine; Morphine; Naltrexone; Neuroblastoma; Neurons; Receptors, Opioid; Receptors, Opioid, delta | 1986 |
Behavioral effects of opioid peptides selective for mu or delta receptors. I. Morphine-like discriminative stimulus effects.
Topics: Animals; beta-Endorphin; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Discrimination Learning; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Morphine; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1986 |
Behavioral effects of opioid peptides selective for mu or delta receptors. II. Locomotor activity in nondependent and morphine-dependent rats.
Topics: Animals; beta-Endorphin; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Morphine Dependence; Motor Activity; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1986 |
Pharmacodynamic supersensitivity and opioid receptor upregulation in the mouse.
Topics: Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Lethal Dose 50; Male; Mice; Morphine; Naltrexone; Receptors, Opioid; Time Factors | 1986 |
Reversible and irreversible binding of beta-funaltrexamine to mu, delta and kappa opioid receptors in guinea pig brain membranes.
Topics: Animals; Brain; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Ethylmaleimide; Guinea Pigs; Kinetics; Male; Membranes; Naloxone; Naltrexone; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sodium Chloride | 1986 |
Evidence for mu opioid receptor mediation of enkephalin-induced electroencephalographic seizures.
Topics: Animals; Electroencephalography; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Naloxone; Naltrexone; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Seizures | 1987 |
Delta receptors in the rat vas deferens.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; In Vitro Techniques; Male; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Vas Deferens | 1986 |
Nonequilibrium opioid antagonist activity of 6,14-dideoxynaltrexone derivatives.
Topics: Animals; Cyclazocine; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Mice; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Structure-Activity Relationship | 1987 |
Multiple interconvertible affinity states for the delta opioid agonist-receptor complex.
Topics: Animals; Cattle; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylmaleimide; Guanylyl Imidodiphosphate; Hippocampus; Kinetics; Morphine; Naltrexone; Receptors, Opioid; Receptors, Opioid, delta; Synaptic Membranes | 1987 |
Modulation of human neuroblastoma transplanted into nude mice by endogenous opioid systems.
Topics: Animals; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Naltrexone; Neoplasm Transplantation; Neuroblastoma; Receptors, Opioid; Transplantation, Heterologous | 1987 |
Effects of opioid peptides on aldosterone production: stimulatory effect of leu-enkephalin.
Topics: Adrenal Cortex; Aldosterone; Animals; Cattle; Diprenorphine; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Naloxone; Naltrexone; Perfusion | 1988 |
Effect of endorphins on heart rate and blood pressure in adult dogs.
Topics: Animals; Atropine; Blood Pressure; Consciousness; Dogs; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Heart; Heart Rate; Naloxone; Naltrexone | 1986 |
Effect of beta-FNA on opiate delta receptor binding.
Topics: Animals; Brain; Cell Membrane; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Naloxone; Naltrexone; Oligopeptides; Protein Conformation; Rats; Receptors, Opioid | 1984 |
Possible involvement of opiate receptors in the pharmacological profiles of antidepressant compounds.
Topics: Animals; Antidepressive Agents; Binding, Competitive; Cerebellum; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; In Vitro Techniques; Kinetics; Male; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid | 1984 |
Mu and delta opioid receptor interactions in a rat model of drug induced seizures.
Topics: Animals; Disease Models, Animal; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Seizures | 1984 |
Hyperthermic response of the cat to intraventricular injection of the opioid delta-receptor agonist D-Ala2-D-Leu5-enkephalin.
Topics: Animals; Body Temperature; Body Temperature Regulation; Cats; Drug Tolerance; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Injections, Intraventricular; Morphine; Naloxone; Naltrexone; Receptors, Opioid; Receptors, Opioid, delta | 1984 |
Comparative antagonism by naltrexone and naloxone of mu, kappa, and delta agonists.
Topics: Animals; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vas Deferens | 1984 |
Relative involvement of mu, kappa and delta receptor mechanisms in opiate-mediated antinociception in mice.
Topics: Acetates; Acetic Acid; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Hot Temperature; Male; Mice; Naloxone; Naltrexone; Pain; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1983 |
Comparison of dynorphin-selective Kappa receptors in mouse vas deferens and guinea pig ileum. Spare receptor fraction as a determinant of potency.
Topics: Animals; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Guinea Pigs; Ileum; Male; Mice; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Receptors, Opioid; Receptors, Opioid, kappa; Structure-Activity Relationship; Vas Deferens | 1983 |
Receptor preference of dynorphin A fragments in the mouse vas deferens determined by different techniques.
Topics: Animals; Drug Tolerance; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Fentanyl; Male; Mice; Naloxone; Naltrexone; Peptide Fragments; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vas Deferens | 1984 |
Characterization of the kappa-subtype of the opiate receptor in the guinea-pig brain.
Topics: Animals; Benzomorphans; Binding Sites; Binding, Competitive; Brain; Cyclazocine; Dihydromorphine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Guinea Pigs; Naloxone; Naltrexone; Narcotics; Phenoxybenzamine; Receptors, Opioid | 1981 |
Naltrexone-induced opiate receptor supersensitivity.
Topics: Animals; Brain; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Female; Guanosine Triphosphate; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid | 1982 |
Relative involvement of receptor subtypes in opioid-induced inhibition of gastrointestinal transit in mice.
Topics: Animals; Charcoal; Cyclazocine; Drug Interactions; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Female; Gastrointestinal Motility; Male; Mice; Morphine; Nalorphine; Naltrexone; Receptors, Opioid | 1983 |
ICI 154,129, a delta-opioid receptor antagonist raises seizure threshold in rats.
Topics: Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Seizures | 1984 |
Opioid antagonism of electroshock-induced seizures.
Topics: Animals; beta-Endorphin; Electroshock; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Mice; Mice, Inbred C57BL; Morphine; Naltrexone; Narcotics; Seizures; Time Factors | 1984 |
Selective actions of central mu and kappa opioid antagonists upon sucrose intake in sham-fed rats.
Topics: Animals; Cerebral Ventricles; Eating; Enkephalin, Leucine-2-Alanine; Infusions, Parenteral; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sucrose | 1995 |
Expression of functional delta opioid receptors in Xenopus oocytes.
Topics: Adenylyl Cyclases; Analgesics; Analysis of Variance; Animals; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Female; Glioma; Hybrid Cells; Isoproterenol; Mice; Naltrexone; Neuroblastoma; Oocytes; Poly A; Rats; Receptors, Opioid, delta; RNA; RNA, Messenger; Xenopus laevis | 1993 |
Analysis of central opioid receptor subtype antagonism of hypotonic and hypertonic saline intake in water-deprived rats.
Topics: Animals; Enkephalin, Leucine-2-Alanine; Hypotonic Solutions; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Saline Solution, Hypertonic; Water Deprivation | 1995 |
Evidence for functional delta-opiate receptors in the rat intestine.
Topics: Acetylcholine; Animals; Cricetinae; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; In Vitro Techniques; Jejunum; Male; Mice; Muscle Contraction; Muscle, Smooth; Naltrexone; Rats; Rats, Wistar; Receptors, Opioid, delta | 1994 |
Central opioid receptor subtype mediation of isoproterenol-induced drinking in rats.
Topics: Animals; Drinking; Enkephalin, Leucine-2-Alanine; Injections, Intraventricular; Injections, Subcutaneous; Isoproterenol; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, mu | 1994 |
Influence of hypertension development on rat tail artery responses to opioid peptides.
Topics: Age Factors; Animals; Dose-Response Relationship, Drug; Dynorphins; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Hypertension; In Vitro Techniques; Male; Naltrexone; Narcotic Antagonists; Phenylephrine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; Receptors, Opioid; Tail; Vasoconstriction | 1995 |
Evidence for chemical differentiation of delta opioid receptor subtypes by the sulfhydryl reagent N-ethylmaleimide.
Topics: Affinity Labels; Animals; Brain; Dose-Response Relationship, Drug; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylmaleimide; Isothiocyanates; Male; Mice; Naltrexone; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta | 1994 |
Lack of involvement of delta-1 opioid receptors in the development of physical dependence on morphine in mice.
Topics: Affinity Labels; Animals; Diarrhea; Enkephalin, Leucine-2-Alanine; Injections, Intraventricular; Injections, Spinal; Isothiocyanates; Male; Mice; Morphine; Naloxone; Naltrexone; Receptors, Opioid, delta; Substance-Related Disorders | 1994 |
Effect of chronic exposure to naltrexone and opioid selective agonists on G protein mRNA levels in the rat nervous system.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Brain; Cerebral Ventricles; Drug Administration Schedule; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Gene Expression; GTP-Binding Proteins; In Situ Hybridization; Infusions, Parenteral; Male; Naltrexone; Narcotics; Oligonucleotide Probes; Organ Specificity; Pyrrolidines; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1994 |
Interaction of [D-Pen2,D-Pen5]enkephalin and [D-Ala2,Glu4]deltorphin with delta-opioid receptor subtypes in vivo.
Topics: Amino Acid Sequence; Analgesics; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Injections, Intraventricular; Isothiocyanates; Male; Mice; Mice, Inbred ICR; Molecular Sequence Data; Naltrexone; Oligopeptides; Pain Measurement; Reaction Time; Receptors, Opioid, delta | 1994 |
Area tempestas modulates the behavioural responses to nociceptive stimuli in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Anticonvulsants; Azocines; Bicuculline; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Escape Reaction; Foot; Hot Temperature; Male; Morphine; Naltrexone; Narcotic Antagonists; Olfactory Pathways; Pain; Phenazocine; Pressure; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid; Seizures; Tail | 1993 |
Differential modulation of angiotensin II and hypertonic saline-induced drinking by opioid receptor subtype antagonists in rats.
Topics: Angiotensin II; Animals; Drinking; Enkephalin, Leucine-2-Alanine; Male; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Saline Solution, Hypertonic | 1994 |
Possible contribution of a glutathione conjugate to the long-duration action of beta-funaltrexamine.
Topics: Analgesia; Animals; Enkephalin, Leucine-2-Alanine; Glutathione; Guinea Pigs; Kinetics; Male; Mice; Morphine; Muscles; Naltrexone; Receptors, Opioid, mu; Structure-Activity Relationship; Vas Deferens | 1993 |
Delta-opioid receptor antagonists attenuate motor activity induced by amphetamine but not cocaine.
Topics: Amphetamine; Animals; Cocaine; Dose-Response Relationship, Drug; Enkephalin, Leucine-2-Alanine; Male; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta | 1993 |
Opioid agonist properties of two oxime derivatives of naltrexone, NPC 831 and NPC 836.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetates; Analgesics; Animals; Binding, Competitive; Bombesin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Ligands; Male; Mice; Naltrexone; Oximes; Pain; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid; Receptors, Opioid, kappa | 1993 |
Evidence for a single functional opioid delta receptor subtype in the mouse isolated vas deferens.
Topics: Animals; Benzylidene Compounds; Drug Tolerance; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; In Vitro Techniques; Isothiocyanates; Male; Mice; Mice, Inbred ICR; Morphinans; Naltrexone; Oligopeptides; Receptors, Opioid, delta; Thiocyanates; Vas Deferens | 1993 |
Involvement of mu1 and mu2 opioid receptor subtypes in tail-pinch feeding in rats.
Topics: Animals; Arousal; Enkephalin, Leucine-2-Alanine; Feeding Behavior; Indoles; Male; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 1993 |
Dose-dependent antagonism of spinal opioid receptor agonists by naloxone and naltrindole: additional evidence for delta-opioid receptor subtypes in the rat.
Topics: Analgesics; Animals; Binding, Competitive; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; In Vitro Techniques; Injections, Spinal; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord | 1993 |
Central opioid receptor subtype antagonists differentially reduce intake of saccharin and maltose dextrin solutions in rats.
Topics: Animals; Drinking Behavior; Enkephalin, Leucine-2-Alanine; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Polysaccharides; Rats; Rats, Sprague-Dawley; Saccharin | 1993 |
Kinetic parameters of antagonism by the delta opioid receptor selective peptide antagonist Boc-Tyr-Pro-Gly-Phe-Leu-Thr against selective and non-selective agonists in the mouse vas deferens.
Topics: Analgesics; Animals; Anticonvulsants; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; In Vitro Techniques; Kinetics; Male; Mice; Mice, Inbred Strains; Morphine Derivatives; Naltrexone; Oligopeptides; Pyrroles; Receptors, Opioid, delta; Thiophenes; Vas Deferens | 1993 |
(D-Ala, D-Leu) enkephalin reduces the binding of GTP in hippocampal membranes.
Topics: Affinity Labels; Animals; Autoradiography; Azides; Electrophoresis, Polyacrylamide Gel; Enkephalin, Leucine-2-Alanine; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Hippocampus; In Vitro Techniques; Indoles; Male; Membranes; Morphinans; Naltrexone; Rats; Rats, Sprague-Dawley | 1993 |
Participation of delta opioid receptor subtypes in the stimulation of adenylyl cyclase activity in rat olfactory bulb.
Topics: Adenylyl Cyclases; Amino Acid Sequence; Animals; Corpus Striatum; Enkephalin, Leucine-2-Alanine; Enzyme Activation; In Vitro Techniques; Isothiocyanates; Male; Molecular Sequence Data; Naltrexone; Olfactory Bulb; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta | 1995 |
Beta-endorphin enhances Concanavalin-A-stimulated calcium mobilization by murine splenic T cells.
Topics: Animals; beta-Endorphin; Biological Transport; Calcium; Concanavalin A; Enkephalin, Leucine-2-Alanine; Female; Mice; Mice, Inbred C57BL; Naltrexone; Receptors, Opioid, delta; Spleen; T-Lymphocytes | 1996 |
Naltrindole sensitive delta 2 opioid receptor mediates invertebrate immunocyte activation.
Topics: Animals; Bivalvia; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Humans; Immune System; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta | 1995 |
Different central opioid receptor subtype antagonists modify maltose dextrin and deprivation-induced water intake in sham feeding and sham drinking rats.
Topics: Animals; Dose-Response Relationship, Drug; Drinking; Eating; Enkephalin, Leucine-2-Alanine; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Polysaccharides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Water Deprivation | 1996 |
Supraspinal administration of opioids with selectivity for mu-, delta- and kappa-opioid receptors produces analgesia in amphibians.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Benzofurans; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Female; Fentanyl; Injections, Intraventricular; Male; Morphine; Naltrexone; Narcotics; Pyrrolidines; Rana pipiens; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1997 |
Evaluation of opioid receptor subtype antagonist effects in the ventral tegmental area upon food intake under deprivation, glucoprivic and palatable conditions.
Topics: Deoxyglucose; Eating; Enkephalin, Leucine-2-Alanine; Evaluation Studies as Topic; Food Deprivation; Hyperphagia; Insulin; Naltrexone; Narcotic Antagonists; Sucrose; Ventral Tegmental Area | 1997 |
Discovery of a novel class of substituted pyrrolooctahydroisoquinolines as potent and selective delta opioid agonists, based on an extension of the message-address concept.
Topics: Animals; Benzamides; Brain; Computer Simulation; Dose-Response Relationship, Drug; Drug Design; Enkephalin, Leucine-2-Alanine; Indoles; Isoquinolines; Ligands; Male; Mice; Models, Molecular; Naltrexone; Narcotic Antagonists; Nociceptors; Piperazines; Pyrroles; Quinolines; Receptors, Opioid, delta; Signal Transduction; Stereoisomerism; Vas Deferens | 1997 |
Opioid regulation of AP-1 DNA-binding activity in NG108-15 cells under conditions of opioid-receptor adaptation.
Topics: Animals; Base Sequence; Binding Sites; Cell Nucleus; Consensus Sequence; Down-Regulation; Enkephalin, Leucine-2-Alanine; Glioma; Hybrid Cells; Mice; Naltrexone; Neuroblastoma; Oligodeoxyribonucleotides; Rats; Receptors, Opioid, delta; Transcription Factor AP-1; Tumor Cells, Cultured; Up-Regulation | 1997 |
Spinal mu, delta and kappa opioids alter chemical, mechanical and thermal sensitivities in amphibians.
Topics: Analgesics, Opioid; Animals; Drug Interactions; Enkephalin, Leucine-2-Alanine; Fentanyl; Injections, Spinal; Morphine; Naltrexone; Narcotic Antagonists; Nociceptors; Pain Measurement; Pain Threshold; Rana pipiens; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sensitivity and Specificity; Spinal Cord | 1997 |
Mutagenesis of the mouse delta opioid receptor converts (-)-buprenorphine from a partial agonist to an antagonist.
Topics: Analgesics, Opioid; Animals; Buprenorphine; Cells, Cultured; Cyclic AMP; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Mice; Mutagenesis; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta | 1998 |
Enkephalins modulate differentiation of normal human keratinocytes in vitro.
Topics: beta-Endorphin; Cell Differentiation; Cell Division; Cells, Cultured; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Humans; Keratinocytes; Keratins; Melphalan; Naltrexone; Narcotic Antagonists; Skin; Transglutaminases | 1997 |
Opioid receptor-mediated inhibition of omega-conotoxin GVIA-sensitive calcium channel currents in rat intracardiac neurons.
Topics: Acetylcholine; Animals; Animals, Newborn; Anti-Arrhythmia Agents; Benzomorphans; Calcium; Calcium Channels; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Heart Conduction System; Ion Channel Gating; Ion Transport; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; omega-Conotoxin GVIA; Parasympathetic Nervous System; Patch-Clamp Techniques; Peptides; Pertussis Toxin; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Virulence Factors, Bordetella | 1998 |
NTI4F: a non-peptide fluorescent probe selective for functional delta opioid receptors.
Topics: Animals; Bridged-Ring Compounds; Cell Line; Dogs; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Fluorescent Dyes; Imides; Microscopy, Confocal; Microscopy, Fluorescence; Morphine; Naltrexone; Receptors, Opioid, delta; Transfection | 1998 |
Delta opioid peptide [D-Ala2,D-leu5]enkephalin blocks the long-term loss of dopamine transporters induced by multiple administrations of methamphetamine: involvement of opioid receptors and reactive oxygen species.
Topics: Animals; Antioxidants; Body Temperature; Carrier Proteins; Dopamine Plasma Membrane Transport Proteins; Enkephalin, Leucine-2-Alanine; Glutathione; Male; Membrane Glycoproteins; Membrane Transport Proteins; Methamphetamine; Mice; Naltrexone; Nerve Tissue Proteins; Reactive Oxygen Species; Receptors, Opioid | 1998 |
Requirement of receptor internalization for opioid stimulation of mitogen-activated protein kinase: biochemical and immunofluorescence confocal microscopic evidence.
Topics: Animals; Biological Transport; Calcium-Calmodulin-Dependent Protein Kinases; COS Cells; Dynamins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; GTP Phosphohydrolases; Immunohistochemistry; Microscopy, Confocal; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Signal Transduction; Stimulation, Chemical | 1999 |
Synthesis and biological activity of 3-substituted 3-desoxynaltrindole derivatives.
Topics: Animals; Benzeneacetamides; Binding, Competitive; Brain; Cell Membrane; Drug Design; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Molecular Structure; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rats; Receptors, Opioid, delta; Structure-Activity Relationship | 1998 |
Constitutive activation of the delta opioid receptor by mutations in transmembrane domains III and VII.
Topics: Amino Acid Substitution; Animals; Cell Membrane; COS Cells; Enkephalin, Leucine-2-Alanine; Guanosine 5'-O-(3-Thiotriphosphate); Ligands; Mice; Models, Molecular; Mutagenesis, Site-Directed; Naltrexone; Narcotic Antagonists; Protein Structure, Secondary; Receptors, Opioid, delta; Structure-Activity Relationship | 1999 |
Ligands for opioid and sigma-receptors improve cardiac electrical stability in rat models of post-infarction cardiosclerosis and stress.
Topics: Animals; Anti-Arrhythmia Agents; beta-Endorphin; Disease Models, Animal; Dynorphins; Enkephalin, Leucine-2-Alanine; Heart; Immobilization; Ligands; Morphine; Myocardial Infarction; Myocardium; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Piperidines; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, delta; Stress, Physiological; Ventricular Fibrillation | 1999 |
Synthesis, opioid receptor binding, and biological activities of naltrexone-derived pyrido- and pyrimidomorphinans.
Topics: Analgesics; Animals; Binding, Competitive; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Ileum; Male; Mice; Mice, Inbred Strains; Morphinans; Morphine; Muscle Contraction; Naltrexone; Protein Binding; Rats; Receptors, Opioid; Vas Deferens | 1999 |
Characterization of delta-opioid receptors and effect of enkephalins on IRD 98 rat epithelial intestinal cell line.
Topics: Analgesics, Opioid; Animals; Binding, Competitive; Cell Line; Cholera Toxin; Cyclic AMP; Dextrorphan; Enkephalin, Leucine-2-Alanine; Enkephalins; Epithelial Cells; Excitatory Amino Acid Antagonists; Fetus; Intestinal Secretions; Intestines; Kinetics; Levorphanol; Naltrexone; Narcotic Antagonists; Neprilysin; Protease Inhibitors; Rats; Receptors, Opioid, delta; Stereoisomerism; Thiorphan; Tritium | 2000 |
Functional evidence that gastroprotection can be induced by activation of central alpha(2B)-adrenoceptor subtypes in the rat.
Topics: Adrenergic alpha-Agonists; Animals; Brain; Clonidine; Enkephalin, Leucine-2-Alanine; Gastric Mucosa; Injections, Intraventricular; Male; Naloxone; Naltrexone; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2 | 2000 |
Activation of mu- and delta-opioid receptors causes presynaptic inhibition of glutamatergic excitation in neocortical neurons.
Topics: Action Potentials; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Excitatory Amino Acid Antagonists; Female; GABA-A Receptor Antagonists; GABA-B Receptor Antagonists; Glutamic Acid; Iontophoresis; Male; Naltrexone; Narcotic Antagonists; Neocortex; Neurons; Rats; Rats, Wistar; Receptors, AMPA; Receptors, GABA-A; Receptors, GABA-B; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, delta; Receptors, Opioid, mu; Synapses; Synaptic Transmission | 2000 |
Expression of functional delta opioid receptors in vascular smooth muscle.
Topics: Animals; Aorta; Binding, Competitive; Calcium; Cell Line; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Gene Expression; Humans; In Vitro Techniques; Male; Membrane Potentials; Muscle, Smooth, Vascular; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; RNA, Messenger; Vasoconstriction | 2000 |
delta-, but not mu- and kappa-, opioid receptor activation protects neocortical neurons from glutamate-induced excitotoxic injury.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Cells, Cultured; Cytoprotection; Embryo, Mammalian; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Excitatory Amino Acid Agonists; Female; Glutamic Acid; L-Lactate Dehydrogenase; Naltrexone; Narcotic Antagonists; Neocortex; Neurons; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2000 |
An immortalized myocyte cell line, HL-1, expresses a functional delta -opioid receptor.
Topics: Analgesics; Benzomorphans; Binding, Competitive; Cell Line; Cells, Cultured; Dose-Response Relationship, Drug; Enkephalin, Leucine-2-Alanine; Guanosine 5'-O-(3-Thiotriphosphate); Kinetics; Ligands; Myocardium; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Time Factors; Tumor Cells, Cultured | 2000 |
Essential activation of PKC-delta in opioid-initiated cardioprotection.
Topics: Acetophenones; Alkaloids; Analgesics; Animals; Benzophenanthridines; Benzopyrans; Benzylidene Compounds; Enkephalin, Leucine-2-Alanine; Enzyme Activation; Enzyme Inhibitors; Heart Rate; Indoles; Ischemic Preconditioning, Myocardial; Isoenzymes; Male; Maleimides; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Naltrexone; Narcotic Antagonists; Phenanthridines; Protein Kinase C; Protein Kinase C-delta; Quinolines; Rats; Rats, Wistar; Receptors, Opioid, delta | 2001 |
The human delta opioid receptor activates G(i1)alpha more efficiently than G(o1)alpha.
Topics: Adenylyl Cyclases; Cell Line; Colforsin; Diprenorphine; Enkephalin, Leucine-2-Alanine; GTP Phosphohydrolases; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine Triphosphate; Heterotrimeric GTP-Binding Proteins; Humans; Kinetics; Naltrexone; Polymerase Chain Reaction; Receptors, Opioid, delta; Recombinant Fusion Proteins; Recombinant Proteins; Transfection | 2001 |
Opioids suppress basal and nicotine-induced catecholamine secretion via a stabilizing effect on actin filaments.
Topics: Actins; Animals; Benzeneacetamides; Cytochalasin B; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Humans; Naltrexone; Narcotics; Nicotine; Norepinephrine; PC12 Cells; Pyrrolidines; Rats | 2001 |
Rostral ventrolateral medullary opioid receptor subtypes in the inhibitory effect of electroacupuncture on reflex autonomic response in cats.
Topics: Animals; Autonomic Nervous System; Cats; Electroacupuncture; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Gallbladder; Medulla Oblongata; Microinjections; Naltrexone; Narcotic Antagonists; Neural Inhibition; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reflex; Somatostatin | 2001 |
Control of the efficiency of agonist-induced information transfer and stability of the ternary complex containing the delta opioid receptor and the alpha subunit of G(i1) by mutation of a receptor/G protein contact interface.
Topics: Cell Membrane; Cells, Cultured; Enkephalin, Leucine-2-Alanine; GTP Phosphohydrolases; GTP-Binding Proteins; Heterotrimeric GTP-Binding Proteins; Humans; Kinetics; Naltrexone; Narcotic Antagonists; Oligonucleotides, Antisense; Receptors, sigma; Recombinant Fusion Proteins; Transfection | 2001 |
Crystal structure of biphalin sulfate: a multireceptor opioid peptide.
Topics: Binding Sites; Crystallography, X-Ray; Enkephalin, Leucine-2-Alanine; Enkephalins; Hydrogen Bonding; Naltrexone; Narcotics; Oligopeptides; Pliability; Protein Conformation; Protein Folding; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship; Substrate Specificity; Tetrahydroisoquinolines | 2002 |
Neuroprotective role of delta-opioid receptors in cortical neurons.
Topics: Animals; Cell Count; Cell Differentiation; Cell Hypoxia; Cell Survival; Cells, Cultured; Cerebral Cortex; Enkephalin, Leucine-2-Alanine; Hypoxia, Brain; L-Lactate Dehydrogenase; Naltrexone; Narcotic Antagonists; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Time Factors | 2002 |
Opioid receptor subtypes differentially modulate serotonin efflux in the rat central nervous system.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Central Nervous System; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Male; Microdialysis; Microinjections; Naltrexone; Nucleus Accumbens; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Serotonin | 2002 |
Role of kappa-opioid receptor activation in pharmacological preconditioning of swine.
Topics: Animals; Arrhythmias, Cardiac; Coronary Circulation; Enkephalin, Leucine-2-Alanine; Hemodynamics; Ischemic Preconditioning, Myocardial; Morphine; Myocardial Infarction; Myocardial Ischemia; Naltrexone; Narcotic Antagonists; Narcotics; Pentazocine; Receptors, Opioid, kappa; Swine | 2003 |
Phosphorylation of activating transcription factor in murine splenocytes through delta opioid receptors.
Topics: Activating Transcription Factor 2; Animals; Blotting, Western; Cyclic AMP Response Element-Binding Protein; Enkephalin, Leucine-2-Alanine; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Naltrexone; Narcotic Antagonists; Phosphorylation; Receptors, Opioid, delta; Signal Transduction; Specific Pathogen-Free Organisms; Spleen; Transcription Factors | 2003 |
HL-1 myocytes exhibit PKC and K(ATP) channel-dependent delta opioid preconditioning.
Topics: Alkaloids; Animals; Benzophenanthridines; Cell Line; Enkephalin, Leucine-2-Alanine; Enzyme Inhibitors; Heart; Ischemic Preconditioning, Myocardial; Kinetics; Membrane Proteins; Muscle Cells; Myocardial Reperfusion; Myocardium; Naltrexone; Phenanthridines; Potassium Channels; Protein Kinase C; Receptors, Opioid, delta | 2003 |
Effect of opioid receptor ligands on the mu-S196A knock-in and mu knockout mouse vas deferens.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Enkephalin, Leucine-2-Alanine; In Vitro Techniques; Ligands; Male; Mice; Mice, Knockout; Mice, Transgenic; Morphine; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Receptors, Opioid; Vas Deferens | 2003 |
Opioid-mediated modulation of calcium currents in striatal and pallidal neurons following reserpine treatment: focus on kappa response.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic Uptake Inhibitors; Alkaloids; Analgesics, Non-Narcotic; Analgesics, Opioid; Analysis of Variance; Animals; Benzophenanthridines; Calcium Channel Blockers; Calcium Channels; Cell Size; Cells, Cultured; Corpus Striatum; Dose-Response Relationship, Drug; Drug Interactions; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enzyme Inhibitors; Male; Membrane Potentials; Naltrexone; Narcotic Antagonists; Neural Inhibition; Neurons; omega-Conotoxin GVIA; Patch-Clamp Techniques; Phenanthridines; Rats; Rats, Wistar; Receptors, Opioid, kappa; Reserpine | 2004 |
Effect of protein kinases on lactate dehydrogenase activity in cortical neurons during hypoxia.
Topics: Animals; Cell Hypoxia; Cells, Cultured; Cerebral Cortex; Cyclic AMP; Embryo, Mammalian; Enkephalin, Leucine-2-Alanine; Enzyme Activators; Enzyme Inhibitors; Female; Hypoxia; L-Lactate Dehydrogenase; Naltrexone; Neurons; Pregnancy; Protein Kinases; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Time Factors | 2004 |
Delta-opioid receptor antagonists exhibit properties of partial delta-receptor agonists in isolated perfused heart.
Topics: Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Heart; In Vitro Techniques; Male; Myocardial Contraction; Myocardial Ischemia; Naltrexone; Oligopeptides; Perfusion; Quinolines; Rats; Rats, Wistar; Receptors, Opioid, delta | 2004 |
Characterisation of opioid receptors involved in modulating circular and longitudinal muscle contraction in the rat ileum.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enteric Nervous System; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Muscle Contraction; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu | 2005 |
Rapid hypoxia preconditioning protects cortical neurons from glutamate toxicity through delta-opioid receptor.
Topics: Animals; Cells, Cultured; Cellular Senescence; Cerebral Cortex; Enkephalin, Leucine-2-Alanine; Glutamic Acid; Hypoxia; Ischemic Preconditioning; L-Lactate Dehydrogenase; N-Methylaspartate; Naltrexone; Narcotic Antagonists; Neurons; Rats; Receptors, Opioid, delta; RNA, Messenger; Time Factors; Up-Regulation | 2006 |
Cortical delta-opioid receptors potentiate K+ homeostasis during anoxia and oxygen-glucose deprivation.
Topics: Analgesics, Opioid; Animals; Cerebral Cortex; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enkephalin, Leucine-2-Alanine; Enzyme Inhibitors; Extracellular Space; Glucose; Homeostasis; Hypoxia, Brain; In Vitro Techniques; Indicators and Reagents; Male; Mice; Mice, Inbred C57BL; Naltrexone; Potassium; Protein Kinase C; Receptors, Opioid, delta; Signal Transduction | 2007 |
Dose-dependent neuroprotection of delta opioid peptide [D-Ala2, D-Leu5] enkephalin in neuronal death and retarded behavior induced by forebrain ischemia in rats.
Topics: Animals; Behavior, Animal; Brain Ischemia; Cell Death; Dose-Response Relationship, Drug; Enkephalin, Leucine-2-Alanine; Injections, Intraventricular; Male; Naltrexone; Narcotic Antagonists; Neurons; Neuroprotective Agents; Prosencephalon; Rats; Rats, Sprague-Dawley | 2007 |
Effects of delta-opioid receptor stimulation and inhibition on hippocampal survival in a rat model of forebrain ischaemia.
Topics: Animals; Brain Ischemia; Cell Survival; Drug Evaluation, Preclinical; Enkephalin, Leucine-2-Alanine; Hippocampus; Male; Naltrexone; Narcotic Antagonists; Neurons; Neuroprotective Agents; Prosencephalon; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta | 2007 |
delta-Opioid receptor stimulation enhances the growth of neonatal rat ventricular myocytes via the extracellular signal-regulated kinase pathway.
Topics: Analgesics, Opioid; Animals; Animals, Newborn; Butadienes; Cell Proliferation; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cytoskeleton; Dose-Response Relationship, Drug; Enkephalin, Leucine-2-Alanine; Extracellular Signal-Regulated MAP Kinases; Heart Ventricles; Myocytes, Cardiac; Naltrexone; Narcotic Antagonists; Nitriles; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Signal Transduction; Staurosporine; Thionucleotides; Time Factors | 2008 |
Mu-opioid receptor in the nucleus submedius: involvement in opioid-induced inhibition of mirror-image allodynia in a rat model of neuropathic pain.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Enkephalin, Leucine-2-Alanine; Hyperalgesia; Ligation; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Neuralgia; Oligopeptides; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Spinal Nerves; Thalamic Nuclei | 2008 |
Neuroprotective role of delta-opioid receptors against mitochondrial respiratory chain injury.
Topics: Animals; Blotting, Western; Cells, Cultured; Cerebral Cortex; Electron Transport; Electrophoresis, Polyacrylamide Gel; Enkephalin, Leucine-2-Alanine; Immunoprecipitation; L-Lactate Dehydrogenase; Mitochondria; Naltrexone; Narcotic Antagonists; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Sodium Azide | 2009 |
Myocardial resistance to ischemic and reperfusion injuries under conditions of chronic administration of opioid receptor agonists and antagonists.
Topics: Animals; Azocines; Enkephalin, Leucine-2-Alanine; Heart; Male; Myocardial Reperfusion Injury; Naltrexone; Narcotic Antagonists; Piperazines; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2008 |
Delta opioid agonist [D-Ala2, D-Leu5] enkephalin (DADLE) reduced oxygen-glucose deprivation caused neuronal injury through the MAPK pathway.
Topics: Animals; Brain Injuries; Cell Hypoxia; Cell Survival; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Enkephalin, Leucine-2-Alanine; Extracellular Signal-Regulated MAP Kinases; Glucose; JNK Mitogen-Activated Protein Kinases; L-Lactate Dehydrogenase; MAP Kinase Signaling System; Naltrexone; Narcotic Antagonists; Neurons; Neuroprotective Agents; p38 Mitogen-Activated Protein Kinases; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta | 2009 |
Delta opioid peptide DADLE and naltrexone cause cell cycle arrest and differentiation in a CNS neural progenitor cell line.
Topics: Analysis of Variance; Animals; Apoptosis; Cell Cycle; Cell Differentiation; Cell Line; Cell Proliferation; DNA Fragmentation; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, Leucine-2-Alanine; Flow Cytometry; In Situ Nick-End Labeling; Naltrexone; Neurons; Rats; Stem Cells; Time Factors; Tubulin | 2010 |
A GPCR/secretase complex regulates beta- and gamma-secretase specificity for Abeta production and contributes to AD pathogenesis.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Carbamates; Cells, Cultured; Dipeptides; Enkephalin, Leucine-2-Alanine; Humans; Mice; Mice, Inbred C57BL; Mice, Transgenic; Multiprotein Complexes; Naltrexone; Narcotic Antagonists; Protein Transport; Receptors, G-Protein-Coupled; Receptors, Opioid, delta; Substrate Specificity; Transport Vesicles | 2010 |
Effects of intracerebroventricular application of the delta opioid receptor agonist [D-Ala2, D-Leu5] enkephalin on neurological recovery following asphyxial cardiac arrest in rats.
Topics: Animals; Asphyxia; CA1 Region, Hippocampal; Cell Survival; Enkephalin, Leucine-2-Alanine; Heart Arrest; Injections, Intraventricular; Male; Maze Learning; Naltrexone; Neurons; Neuroprotective Agents; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta | 2010 |
Activation of the δ-opioid receptor inhibits serum deprivation-induced apoptosis of human liver cells via the activation of PKC and the mitochondrial pathway.
Topics: Apoptosis; bcl-2-Associated X Protein; Cytochromes c; Enkephalin, Leucine-2-Alanine; Gene Expression; Hepatocytes; Humans; Liver; Liver Diseases; Membrane Potential, Mitochondrial; Mitochondria; Naltrexone; Protein Kinase C; Proto-Oncogene Proteins c-bcl-2; Receptors, Opioid, delta; Serum; Signal Transduction; Stress, Physiological; Tumor Cells, Cultured | 2011 |
[DADLE suppresses the proliferation of human liver cancer HepG2 cells by activation of PKC pathway and elevates the sensitivity to cis-diammine dichloridoplatium].
Topics: Antineoplastic Agents; Cell Cycle; Cell Proliferation; Cisplatin; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Enkephalin, Leucine-2-Alanine; Hep G2 Cells; Humans; Naltrexone; Phosphorylation; Protein Kinase C; Receptors, Opioid, delta; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate | 2012 |