naltrexone has been researched along with enkephalin, ala(2)-mephe(4)-gly(5)- in 359 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 28 (7.80) | 18.7374 |
| 1990's | 183 (50.97) | 18.2507 |
| 2000's | 110 (30.64) | 29.6817 |
| 2010's | 37 (10.31) | 24.3611 |
| 2020's | 1 (0.28) | 2.80 |
| Authors | Studies |
|---|---|
| Bell, GI; Chen, Y; Kong, H; Raynor, K; Reisine, T; Yasuda, K; Yu, L | 1 |
| Adapa, ID; Auh, JS; Berzetei-Gurske, IP; Brandt, SR; Craymer, K; Farrington, L; Haggart, D; Kennedy, JM; O'Brien, A; Polgar, WE; Rodriguez, L; Schwartz, RW; Toll, L; White, A | 1 |
| Grundt, P; Husbands, SM; Jales, AR; Lewis, JW; Traynor, JR | 1 |
| Ananthan, S; Bartlett, JL; Bilsky, EJ; Davis, P; Dersch, CM; Khare, NK; Porreca, F; Rothman, RB; Saini, SK; Seitz, LE | 1 |
| Bidlack, JM; Knapp, BI; Neumeyer, JL; Peng, X | 1 |
| Al-Khrasani, M; Ballet, S; Benyhe, S; Borics, A; Feytens, D; Fürst, Z; Kövér, KE; Lovas, S; Tömböly, C; Tóth, G; Tourwé, D | 1 |
| Bidlack, JM; Bu, Y; Cohen, DJ; Lou, R; Lu, Q; VanAlstine, MA; Wentland, MP | 1 |
| Aschenbach, LC; Cassidy, MP; Chen, J; Dewey, WL; Gabra, BH; Li, G; Selley, DE; Stevens, DL; Westkaemper, RB; Zhang, Y | 1 |
| Aschenbach, LC; He, H; Li, G; Selley, DE; Zhang, Y | 1 |
| Bidlack, JM; Bu, Y; Cohen, DJ; Denhardt, C; Ganorkar, R; Guo, C; Jin, J; Lou, R; Lu, Q; VanAlstine, MA; Wentland, MP | 1 |
| Azar, MR; Cashman, JR; Ghirmai, S | 1 |
| Burgman, M; Grinnell, S; Haselton, N; Majumdar, S; Ocampo, J; Pasternak, AR; Pasternak, GW | 1 |
| Dewey, WL; Kellogg, GE; Mosier, PD; Scoggins, KL; Selley, DE; Stevens, DL; Yuan, Y; Zaidi, SA; Zhang, Y | 1 |
| Briddon, SJ; Canals, M; Graham, B; Kellam, B; Scammells, PJ; Schembri, LS; Stoddart, LA | 1 |
| Bourgoin, S; Cesselin, F; Collin, E; Ferhat, L; Hamon, M; Mantelet, S; Mauborgne, A | 1 |
| Pinnock, RD | 2 |
| Bourgoin, S; Cesselin, F; Collin, E; Ferhat, L; Hamon, M | 1 |
| Kane, K; McIntosh, M; Parratt, J | 1 |
| Giles, A; Landymore, KM; Wilkinson, M | 1 |
| De Vries, TJ; Hogenboom, F; Hruby, VJ; Mulder, AH; Portoghese, PS; Schoffelmeer, AN | 1 |
| Malmberg, AB; Yaksh, TL | 1 |
| Billings, B; Candido, J; Duttaroy, A; Yoburn, BC | 1 |
| Herz, A; Shippenberg, TS; Spanagel, R | 1 |
| Kameyama, T; Toyoshi, T; Ukai, M | 5 |
| Cometta-Morini, C; Kamal, J; Loew, G; Maguire, P; Tsai, N; Upton, C | 1 |
| Kastin, AJ; Kersh, D; Wyatt, A; Zadina, JE | 1 |
| Franklin, TG; Traynor, JR | 1 |
| Bourgoin, S; Cesselin, F; Collin, E; Hamon, M; Mantelet, S | 1 |
| Lewis, ME; Li, SX; Liu-Chen, LY | 1 |
| Calenco-Choukroun, G; Daugé, V; Féger, J; Gacel, G; Roques, BP | 1 |
| Abdelhamid, EE; Portoghese, PS; Sultana, M; Takemori, AE | 1 |
| Mjanger, E; Yaksh, TL | 1 |
| Chang, SC; Lutfy, K; Sierra, V; Yoburn, BC | 1 |
| Hoffman, DC; West, TE; Wise, RA | 1 |
| Collins, JG; Kitahata, LM; Nakatani, K; Omote, K | 1 |
| de Costa, BR; Drower, EJ; Hammond, DL; Rafferty, MF; Rice, KC; Stapelfeld, A | 1 |
| Portoghese, PS; Sofuoglu, M; Takemori, AE | 2 |
| Billington, CJ; Grace, M; Levine, AS | 1 |
| Kamei, J; Kasuya, Y; Tanihara, H | 1 |
| Cowan, A; Li, SX; Liu-Chen, LY; Wheeler-Aceto, H | 1 |
| Adams, JU; Holtzman, SG | 1 |
| Butler, B; Gunion, MW; Miller, S; Moore, RD; Morley, JE; Rosenthal, MJ; Zib, B | 1 |
| Duckles, SP; Li, YJ | 1 |
| Kromer, W | 1 |
| Fischbach, PS; McCleskey, EW; Schroeder, JE; Zheng, D | 1 |
| Baamonde, A; Daugé, V; Gacel, G; Roques, BP | 1 |
| Pasternak, GW; Paul, D; Pick, CG | 1 |
| Jin, CB; Rockhold, RW | 1 |
| Bykov, V; Holaday, JW; Jacobson, AE; Long, JB; Rice, KC; Rothman, RB | 2 |
| Billington, CJ; Grace, M; Levine, AS; Portoghese, PS | 1 |
| Allen, JT; Brostrom, PA; DeHaven-Hudkins, DL; Ferkany, JW; Kaplita, PV; Lesko, LJ; Mavunkel, BJ; Rzeszotarski, WJ; Steranka, LR | 1 |
| Lawrence, AJ; Traynor, JR | 1 |
| Chalmers, J; Drolet, G; Morilak, DA | 1 |
| Birch, PJ; Hayes, AG; Lawrence, AJ; Rogers, H; Traynor, JR | 1 |
| Calcagnetti, DJ; Holtzman, SG | 1 |
| Klein, P; Nelson, WL; Olsen, LD; Simon, EJ; Yao, YH | 1 |
| Lewis, ME; Li, SX; Liu-Chen, LY; Rohrbach, KW | 1 |
| Heijna, MH; Hogenboom, F; Mulder, AH; Padt, M; Portoghese, PS; Schoffelmeer, AN | 1 |
| Fuentes, JA; Iglesias, T; Jiménez, I | 1 |
| Medzihradsky, F; Nordby, GL; Remmers, AE | 1 |
| Lutfy, K; Sierra, V; Yoburn, BC | 1 |
| Echevarria, E; Holaday, JW; Lipkowski, AW; Portoghese, PS; Takemori, AE; Tortella, FC | 1 |
| McLaughlin, PJ; Zagon, IS | 2 |
| Brady, LS; Bykov, V; Holaday, JW; Jacobson, AE; Long, JB; Rice, KC; Rothman, RB | 1 |
| Bardo, MT; Neisewander, JL; Nonneman, AJ; Rowlett, JK | 1 |
| Coscia, CJ; Laskowski, MB; Moudy, AM | 1 |
| Evans, RG; Ludbrook, J; Van Leeuwen, AF | 1 |
| Gioannini, TL; Hiller, JM; Liu, YF; Park, YH; Simon, EJ | 1 |
| Garzón, J; Sánchez-Blázquez, P; Ulibarri, I | 1 |
| Heyman, JS; Mosberg, HI; Mulvaney, SA; Porreca, F | 1 |
| Christie, MJ; North, RA; Williams, JT | 1 |
| Burks, TF; Fox, DA | 1 |
| Bhargava, HN; Rapaka, RS; Renugopalakrishnan, V | 1 |
| Ho, BY; Naeseth, JS; Portoghese, PS; Takemori, AE | 1 |
| Cox, BM; Frattali, A; Portoghese, PS; Takemori, AE; Werling, LL | 1 |
| Dougall, IG; Leff, P | 1 |
| Landymore, KM; Wilkinson, M | 1 |
| Hayes, AG; Sheehan, MJ; Tyers, MB | 2 |
| Gosnell, BA; Grace, M; Levine, AS | 1 |
| McLean, S; Rothman, RB | 1 |
| Holtzman, SG; Locke, KW | 2 |
| Adler, B; Inturrisi, CE; Nunes, FA; Pasternak, GW; Yoburn, BC | 1 |
| Liu-Chen, LY; Tam, SW | 1 |
| Mosberg, HI; Robles, L; Tortella, FC | 1 |
| Carter, A; Smith, CF | 1 |
| Abhold, R; Kalivas, PW | 1 |
| Medzihradsky, F; Yabaluri, N | 2 |
| Laorden, ML; Llobell, F | 1 |
| Fukuda, K; Fukushima, N; Misu, Y; Miyamae, T; Sasaki, Y; Takeshima, H; Ueda, H | 1 |
| Fukushima, N; Hayashi, C; Katayama, T; Misu, Y; Miyamae, T; Ueda, H | 1 |
| Armstead, WM | 1 |
| Imai, Y; Schäfer, M; Stein, C; Uhl, GR | 1 |
| Hammond, DL; Littell, L; Stewart, PE | 1 |
| Gong, QZ; Hamm, RJ; Jiang, JY; Lyeth, BG; Young, HF | 1 |
| Maggi, R; Martini, L; Pimpinelli, F; Piva, F | 1 |
| Alsasua, A; Martín, MI; Parra, L; Pérez-Vizcaíno, F; Tamargo, J | 1 |
| Iwamoto, Y; Kamei, J; Kasuya, Y; Misawa, M; Nagase, H; Ohsawa, M; Saitoh, A; Suzuki, T | 1 |
| Bélisle, S; Bellabarba, D; Gallo-Payet, N; Lehoux, JG; Petit, A | 1 |
| Kushner, L; Tamir, M | 1 |
| Devine, DP; Leone, P; Pocock, D; Wise, RA | 1 |
| Randić, M; Wang, RA | 1 |
| Kradel, BK; Monroe, PJ; Smith, DJ; Smith, DL | 1 |
| Crisp, T; Keck, BJ; Stafinsky, JL; Uram, M | 1 |
| Kuznetsov, A; Ma, GH; Miller, RJ; Philipson, LH | 1 |
| Coenen, A; Lasoń, W; Machelska, H; Przewłocka, B; Przewłocki, R; van Luijtelaar, G | 1 |
| Adams, JU; Li, S; Liu-Chen, LY; Yang, HH | 1 |
| Elliott, J; Lambert, DG; Smart, D; Traynor, JR | 2 |
| Almeida, OF; Shippenberg, TS; Spanagel, R | 1 |
| Iwamoto, Y; Kamei, J; Kasuya, Y; Kawashima, N; Misawa, M; Nagase, H; Suzuki, T | 1 |
| Gewiss, M; Goldberg, SR; Marley, RJ; Schindler, CW; Shimosato, K; Thorndike, E | 1 |
| Dworkin, SI; Martin, TJ; Smith, JE | 2 |
| Ingenito, AJ; Wong, SC | 1 |
| Búzás, B; Cox, BM; Izenwasser, S | 1 |
| Guirimand, F; Le Bars, D; Strimbu-Gozariu, M; Willer, JC | 1 |
| Sheiner, LB; Troconiz, IF; Verotta, D | 1 |
| Buéno, L; Gué, M; Junien, JL | 1 |
| Kameyama, T; Mizutani, M; Ukai, M | 1 |
| Kameyama, T; Mizutani, M; Sasaki, Y; Toyoshi, T; Ukai, M | 1 |
| Burke, TF; Lewis, JW; Medzihradsky, F; Woods, JH | 1 |
| Benoliel, JJ; Bourgoin, S; Cesselin, F; Collin, E; Hamon, M; Mauborgne, A | 1 |
| Kwok, YN; McIntosh, C; Yago, V | 1 |
| Kim, YH; Lim, JS; Song, DK; Suh, HW; Tseng, LF | 1 |
| Noble, F; Roques, BP; Smadja, C | 1 |
| Bhargava, HN; Matwyshyn, GA; Reddy, PL; Thorat, SN | 1 |
| Eisenberg, RM | 2 |
| Giagnoni, G; Massi, P; Parolaro, D; Patrini, G; Rubino, T; Venier, I | 1 |
| Randich, A; Robertson, JD; Willingham, T | 1 |
| Bhargava, HN; Matwyshyn, GA; Reddy, PL | 1 |
| D'Alecy, LG; Mayfield, KP | 1 |
| Hammond, DL; Stewart, PE | 2 |
| Ahmed, MS; Cemerikic, B; Zamah, R | 1 |
| Maier, SF; Mooney-Heiberger, K; Watkins, LR; Wiertelak, EP; Yang, HY | 1 |
| Martin, BR; Smith, PB; Welch, SP | 1 |
| Brusa, L; D'Amore, A; Lorenzini, P; Massotti, M | 1 |
| Fukushima, N; Misu, Y; Miyamae, T; Ueda, H | 1 |
| Mulder, AH; Ronken, E; Schoffelmeer, AN | 1 |
| Côté, TE; Izenwasser, S; Weems, HB | 1 |
| Mokhtari, M; Tafani, JA; Zajac, JM | 1 |
| Davis, T; Duttaroy, A; Shah, S; Yoburn, BC | 1 |
| Funada, M; Misawa, M; Nagase, H; Narita, M; Suzuki, T | 1 |
| Hitosugi, H; Kamei, J; Kasuya, Y; Kawashima, N; Misawa, M; Nagase, H | 1 |
| DeHaven-Hudkins, DL; Komer, KM; Mavunkel, BJ; Peterson, JA; Rzeszotarski, WJ | 1 |
| Lanthorn, TH; Watson, GB | 1 |
| Dosaka-Akita, K; Holaday, JW; Long, JB; Tortella, FC | 1 |
| Kameyama, T; Mori, E; Ukai, M | 1 |
| Carter, BD; Medzihradsky, F | 1 |
| Iwamoto, Y; Kamei, J; Kasuya, Y; Misawa, M; Nagase, H; Suzuki, T | 1 |
| Collins, KA; Portoghese, PS; Tseng, LF | 1 |
| De Vries, TJ; Mulder, AH; Schoffelmeer, AN; Tjon Tien Ril, GH; Van der Laan, JW | 1 |
| Bourgoin, S; Cesselin, F; Collin, E; Frechilla, D; Hamon, M; Le Bars, D; Pohl, M | 1 |
| Tiseo, PJ; Yaksh, TL | 1 |
| Desmeules, JA; Guilbaud, G; Kayser, V | 1 |
| Baumhaker, Y; Gafni, M; Keren, O; Sarne, Y | 1 |
| Lazar, DF; Medzihradsky, F | 1 |
| Magyar, A; Medzihradszky, K; Rónai, AZ | 1 |
| Cowan, A; Hunter, JC; Kovelowski, CJ; Lai, J; Malan, TP; Ossipov, MH; Porreca, F; Wheeler-Aceto, H | 1 |
| Howard, BA; Wilson, JR | 1 |
| Imai, Y; Kreek, MJ; Rubenfeld, JM; Uhl, GR; Unterwald, EM; Wang, JB | 1 |
| Davenport, KE; Houdi, AA; Marson, L; Van Loon, GR | 1 |
| Endoh, T; Misawa, M; Mori, T; Nagase, H; Suzuki, T; Tsuji, M | 1 |
| Bot, G; Chahl, LA | 1 |
| George, SR; Kouvelas, A; O'Dowd, BF; Pak, Y; Rasmussen, J; Scheideler, MA | 1 |
| Feuerstein, TJ; Gleichauf, O; Jackisch, R; Landwehrmeyer, GB; Peckys, D; Scheremet, R | 1 |
| Kübler, W; Mura, RA; Niroomand, F; Piacentini, L | 1 |
| Mokha, SS; Wang, XM; Yan, JQ; Zhang, KM | 1 |
| Yuan, CS | 1 |
| Nelson, WL; Palmer, RB; Upthagrove, AL | 1 |
| Breivogel, CS; Childers, SR; Selley, DE | 1 |
| Castelli, MP; Diaz, G; Fadda, P; Gessa, GL; Mameli, M; Melis, M | 1 |
| Bombelli, R; Cosentino, M; Ferrari, M; Frigo, G; Giaroni, C; Lecchini, S; Marino, F; Rasini, E | 1 |
| Chao, CC; Gekker, G; Hu, S; Lipovsky, MM; Molitor, TW; Peterson, PK; Sowa, G | 1 |
| Billington, CJ; Kotz, CM; Levine, AS | 1 |
| Lishmanov, IuB; Maslov, LN; Naryzhnaia, NV | 1 |
| Bodnar, RJ; Leventhal, L; Pasternak, GW; Rossi, GC; Stevens, LB | 1 |
| Childers, SR; deMontis, MG; Martin, TJ; Selley, DE; Sim, LJ | 1 |
| Childers, SR; Sim, LJ | 1 |
| Adams, DJ; Trequattrini, C | 1 |
| Billington, CJ; Giraudo, SQ; Levine, AS | 1 |
| Gross, GJ; Hsu, AK; Schultz, JE | 1 |
| Eckersell, CB; Micevych, PE; Popper, P | 1 |
| Desprat, C; Zajac, JM | 1 |
| Butelman, ER; Ko, MC; Traynor, JR; Woods, JH | 1 |
| Gosnell, BA; Kelley, AE; Zhang, M | 1 |
| Crisp, T; Gordon, TL; Hoskins, DL | 1 |
| Bayer, BM; Mellon, RD | 1 |
| Anton, B; Evans, CJ; Lam, H; To, T; Unterwald, EM | 1 |
| Butelman, ER; Ko, MC; Woods, JH | 1 |
| Borsodi, A; Hosztafi, S; Nevin, ST; Rónai, AZ; Spetea, M; Tóth, G | 1 |
| Lysle, DT; Schneider, GM | 1 |
| Billington, CJ; Giraudo, SQ; Kotz, CM; Levine, AS | 1 |
| Hata, F; Nishio, H; Nishiwaki, H; Saitoh, N; Takeuchi, T | 1 |
| Cheung, P; Li, JG; Liu-Chen, LY; Raffa, RB; Tzeng, TB | 1 |
| Andoh, T; Ito, H; Kamiya, Y; Oka, K; Watanabe, I | 1 |
| DeMontis, MG; Dworkin, SI; Kim, SA; Martin, TJ; Sizemore, GM; Smith, JE | 1 |
| Becker, A; Grecksch, G; Hoellt, V; Schroeder, H; Schroeder, U | 1 |
| Foxx-Orenstein, AE; Grider, JR; Jin, JG | 1 |
| Dersch, C; Kubota, H; McCullough, K; Pinto, J; Rice, KC; Rothman, RB | 1 |
| Liu, H; Mazarati, A; Wasterlain, C | 1 |
| Kowalski, J | 1 |
| Hallermann, S; Müller, W; Swandulla, D | 1 |
| Azmitia, EC; Miller, JH | 1 |
| Foss, JF; Yuan, CS | 1 |
| Fujimura, T; Kastin, AJ; Katsuyama, S; Murayama, K; Sakurada, S; Sakurada, T; Ueda, H; Yuki, M; Zadina, JE | 1 |
| Clark, MJ; Emmerson, PJ; Medzihradsky, F; Remmers, AE | 1 |
| Baamonde, A; Gutiérrez, M; Hidalgo, A; Menéndez, L; SanMartín, S | 1 |
| Ananthan, S; Bilsky, EJ; Carter, RL; Davis, P; Dersch, CM; Kezar, HS; Porreca, F; Rice, KC; Rothman, RB; Saini, SK; Wells, JL; Xu, H | 1 |
| Heyliger, SO; Jackson, C; Rice, KC; Rothman, RB | 1 |
| Fields, HL; Hirakawa, N; Tershner, SA | 1 |
| Dun, NJ; Hwang, BH; Mizoguchi, H; Nagase, H; Narita, M; Oji, DE; Tseng, LF | 1 |
| Dubner, R; Qiu, C; Ren, K; Sora, I; Uhl, G | 1 |
| Goto, K; Ishige, A; Komatsu, Y; Omiya, Y | 1 |
| Bidlack, JM; Cioffi, CL; Cohen, DJ; Colasurdo, AM; Duan, W; Wentland, MP; Xu, G; Ye, Y | 1 |
| Esashi, A; Kisara, K; Nakagawasai, O; Niijima, F; Sakurada, S; Tadano, T; Takahashi, N; Tan-No, K; Yonezawa, A | 1 |
| Hayashi, T; Kisara, K; Kutsuwa, M; Sakurada, C; Sakurada, S; Sakurada, T; Sato, T; Takeda, S; Tan-No, K; Yuki, M | 1 |
| Helmstetter, FJ; Tershner, SA | 1 |
| Jones, RM; Portoghese, PS | 1 |
| Balestra, B; Brecha, NC; D'Agostino, G; Fiori, E; Minnis, J; Sternini, C; Tonini, M | 1 |
| Ballet, S; Cesselin, F; Collin, E; Hamon, M; Mauborgne, A | 1 |
| Cheong, YP; Cho, KP; Kim, CJ; Kim, JK; Kim, KW; Kwun, J; Woo, RS | 1 |
| Altememi, GF; Mandyam, CD; Standifer, KM | 1 |
| Bian, D; Cannon, DG; Kim, SA; Martin, TJ; Porreca, F; Sizemore, GM; Smith, JE | 1 |
| Akil, H; Bonner, G; Meng, F | 1 |
| Lysle, DT; Nelson, CJ; Schneider, GM | 1 |
| Balboni, G; Bryant, SD; Butterworth, J; Guerrini, R; Labarre, M; Lazarus, LH; Payza, K; Salvadori, S; Schmidhammer, H; St-Onge, S | 1 |
| Ostermeier, AM; Schlösser, B; Schwender, D; Sutor, B | 1 |
| Carrigan, KA; Lysle, DT; Nelson, CJ | 1 |
| Fujimura, T; Hayashi, T; Kastin, AJ; Murayama, K; Sakurada, C; Sakurada, S; Sakurada, T; Takeshita, M; Yonezawa, A; Yuhki, M; Zadina, JE | 1 |
| Husbands, SM; Jales, AR; Lewis, JW | 1 |
| Chieng, B; Christie, MJ; Osborne, PB | 1 |
| Haddad, GG; Xia, Y; Zhang, J | 1 |
| Chao, CC; Hegg, CC; Hu, S; Peterson, PK; Thayer, S | 1 |
| Cho, KP; Kim, KW; Shin, BS; Son, Y | 1 |
| Kieffer, BL; Maldonado, R; Matthes, HW; Melchiorri, P; Negri, L; Severini, C | 1 |
| Hammond, DL; Hurley, RW | 1 |
| Dermitzaki, E; Gravanis, A; Margioris, AN; Stournaras, C; Venihaki, M | 1 |
| Boudinot, E; Champagnat, J; Denavit-Saubié, M; Dubois, C; Foutz, AS; Kieffer, BL; Matthes, HW; Morin-Surun, MP | 1 |
| Alt, A; Fan, CD; McFadyen, IJ; Traynor, JR; Woods, JH | 1 |
| Kalra, A; Sluka, KA; Urban, MO | 1 |
| Liu, JG; Prather, PL | 1 |
| Bodnar, RJ; Christian, G; Echo, JA; Lamonte, N; Ragnauth, A; Znamensky, V | 1 |
| Micevych, PE; Sinchak, K | 1 |
| Billington, CJ; Grace, MK; Jewett, DC; Jones, RM; Levine, AS; Portoghese, PS | 1 |
| Liu, JG; Prather, PL; Ruckle, MB | 1 |
| Ananthan, S; Lu, YF; Rice, KC; Rothman, RB; Xu, H | 1 |
| Fujimura, T; Hayashi, T; Kastin, AJ; Murayama, K; Narita, M; Orito, T; Sakurada, C; Sakurada, S; Sakurada, T; Suzuki, T; Tan-no, K; Tseng, LF; Yuhki, M; Zadina, JE | 1 |
| Ackerman, TF; Bodnar, RJ; Christian, G; Echo, JA; Lamonte, N; Znamensky, V | 1 |
| Ackerman, TF; Bodnar, RJ; Christian, G; Echo, JA; Lamonte, N | 1 |
| Brown, DR; Townsend, D | 1 |
| Commons, KG; Kow, LM; Ogawa, S; Pfaff, DW | 1 |
| Ackerman, TF; Bodnar, RJ; Echo, JA; Lamonte, N | 1 |
| Bastia, E; Bertorelli, R; Citterio, F; Corradini, L; Forlani, A; Ongini, E | 1 |
| González-Maeso, J; Meana, JJ; Rodríguez-Puertas, R | 1 |
| Auerbach, SB; Tao, R | 1 |
| Hall, FS; Mizoguchi, H; Nagase, H; Narita, M; Sora, I; Tseng, LF; Uhl, GR; Wu, HE | 1 |
| Sterious, SN; Walker, EA | 1 |
| David Clark, J; Demirci, H; Gharagozlou, P; Lameh, J | 1 |
| Hung, KC; Leitermann, R; Mizoguchi, H; Nagase, H; Narita, M; Suzuki, T; Tseng, LF | 1 |
| Borgland, SL; Christie, MJ; Connor, M; Furness, JB; Osborne, PB | 1 |
| Lunzer, MM; Portoghese, PS | 1 |
| Leitermann, R; Mizoguchi, H; Nagase, H; Spaulding, A; Tseng, LF; Wu, HE | 1 |
| Sacerdote, P | 1 |
| Billington, CJ; Levine, AS; MacDonald, AF | 1 |
| Bartus, RT; Basile, AS; Blaustein, M; Dean, RL; Emerich, DF; Hotz, J; Perdomo, B | 1 |
| Brillet, K; Bucher, B; Lecat, S; Pattus, F; Perret, BG; Rabut, G; Wagner, R | 1 |
| Brailoiu, GC; Dun, NJ; Ohtubo, Y; Wu, SY | 1 |
| Brown, DR; Townsend, DW | 1 |
| Kim, EM; Levine, AS; O'Hare, E; Quinn, JG | 2 |
| Bonci, A; Fields, HL; Hjelmstad, GO; Margolis, EB | 1 |
| Izenwasser, S; Platt, DM; Rowlett, JK; Spealman, RD | 1 |
| Bernardi, G; D'Angelo, V; Lavaroni, F; Martella, G; Martorana, A; Spadoni, F; Stefani, A | 1 |
| Kabuto, C; Sakurada, S; Takeshita, M; Uchiyama, H; Uwai, K | 1 |
| Emmerson, PJ; McKinzie, JH; Mitch, CH; Statnick, MA; Surface, PL; Suter, TM | 1 |
| Fujimura, T; Ito, K; Kawamura, S; Mizoguchi, H; Murayama, K; Nakayama, D; Sakurada, C; Sakurada, S; Sakurada, T; Sato, T; Watanabe, C; Watanabe, H | 1 |
| Glatzer, NR; Smith, BN | 1 |
| Coupar, IM; Gray, AC; White, PJ | 1 |
| Fong, J; Jones, RM; Kostenis, E; Lunzer, MM; Portoghese, PS; Sharma, SK; Waldhoer, M; Whistler, JL | 1 |
| Bart, G; Bidlack, JM; Borg, L; Ho, A; Kreek, MJ; Schluger, JH | 1 |
| Bourgoin, S; Glowinski, J; Godeheu, G; Jabourian, M; Kemel, ML; Ozon, S; Pérez, S; Venance, L | 1 |
| Cools, AR; Hirose, N; Koshikawa, N; Murakawa, K; Nagase, H; Oi, Y; Suzuki, T; Takada, K | 1 |
| Kaneko, C; Kuzumaki, N; Matsuzawa, K; Miyoshi, K; Nagumo, Y; Nakajima, M; Nanjo, K; Narita, M; Suzuki, T; Yamazaki, M | 1 |
| Baamonde, A; García, V; Hidalgo, A; Juárez, L; Lastra, A; Menéndez, L | 1 |
| Flau, K; Kathmann, M; Redmer, A; Schlicker, E; Tränkle, C | 1 |
| Aloyo, VJ; Nicklous, DM; Simansky, KJ; Ward, HG | 1 |
| Iordanova, MD; McNally, GP; Westbrook, RF | 1 |
| Bidlack, JM; Parkhill, AL | 1 |
| Simansky, KJ; Ward, HG | 1 |
| Martin, TJ; McIntosh, S; Smith, JE | 1 |
| Fields, HL; Lee, BS; Woolley, JD | 1 |
| Manzanares, J; Oliva, JM | 1 |
| Sadee, W; Sun, X; Wang, D | 1 |
| Fields, HL; Lee, BS; Taha, SA; Woolley, JD | 1 |
| Beattie, DT; Cheruvu, M; Johnson-Rabidoux, S; Kaufman, E; Mai, N; O'Keefe, M; Peterson, C; Vickery, R | 1 |
| Herzog, H; Loacker, S; Sayyah, M; Schwarzer, C; Wittmann, W | 1 |
| Baskett, JA; Kracke, GR; Lever, JR; Miller, DK; Rodvelt, KR; Will, MJ | 1 |
| Garcia, JG; Moreno-Vinasco, L; Moss, J; Sammani, S; Singleton, PA; Wanderling, SL | 1 |
| Billington, CJ; Chimukangara, M; Grace, MK; Levine, AS; Naleid, AM | 1 |
| Devidze, N; Kow, LM; Lee, AW; Pataky, S; Pfaff, DW; Zhang, Q; Zhou, J | 1 |
| Ahtee, L; Korpi, ER; Piltonen, M; Tuominen, RK; Vihavainen, T | 1 |
| Ko, MC; Traynor, JR; Woods, JH; Xie, H | 1 |
| Komatsu, T; Mizoguchi, H; Morimoto, M; Sakurada, S; Sakurada, T; Sato, T; Sawai, T; Watanabe, C; Watanabe, H; Yonezawa, A | 1 |
| Ballard, ME; Harmon, AC; Holtzman, SG; White, DA | 1 |
| Abrahao, KP; Quadros, IM; Souza-Formigoni, ML | 1 |
| Gyires, K; Zádori, Z | 1 |
| Beckman, TR; Billington, CJ; Levine, AS; Shi, Q | 1 |
| Bradbury, FA; Carroll, FI; Divin, MF; Traynor, JR | 1 |
| Connor, M | 1 |
| Avila, MA; Brandão, ML; Castilho, VM; De Ross, J; Nobre, MJ; Ruggiero, RN | 1 |
| Kim, EM; O'Hare, E; Quinn, JG; Spanswick, D | 1 |
| Al-Khrasani, M; Asim, MF; Friedmann, T; Furst, S; Király, KP; Riba, P; Schmidhammer, H; Sobor, M; Spetea, M | 1 |
| McGuirk, SR; Pardee, AL; Pritchett, CE; Will, MJ | 1 |
| Belcheva, MM; Coscia, CJ; Ezerskiy, LA; Hahn, JW; He, J; Jagwani, S; Kim, E; Rendell, VR; Wesselschmidt, R | 1 |
| Acton, PD; Brandt, MR; Cai, C; Chevalier, KM; Codd, EE; Colburn, RW; Flores, CM; Ma, J; Peng, S; Stone, DJ; Zhang, SP; Zhu, Y | 1 |
| Alayan, A; Bayer, B; Dretchen, KL; Gillis, RA; Herman, MA; Sahibzada, N; Verbalis, J | 1 |
| Beinborn, M; Ci, L; Fortin, JP; Goldstein, C; Huggins, GS; Kopin, AS; Montefusco, MC; Peter, I; Reis, SE; Schroeder, J | 1 |
| Cleary, DR; Fyfe, LW; Ingram, SL; Macey, TA; Morgan, MM | 1 |
| McCall, JG; Parker, KE; Will, MJ | 1 |
| den Hollander, BR; Pattij, T; Schetters, D; Schoffelmeer, AN; van Es, IE; van Mourik, Y; Wiskerke, J | 1 |
| Hentges, ST; Pennock, RL | 1 |
| Balleine, BW; Cely, IC; Maidment, NT; Wassum, KM | 1 |
| Buechler, NL; Childers, SR; Ewan, EE; Kim, SA; Martin, TJ; Xiao, R | 1 |
| Gear, RW; Levine, JD | 1 |
| Kemppainen, H; Kiianmaa, K; Raivio, N; Suo-Yrjo, V | 1 |
| Arttamangkul, S; Cleary, DR; Heinricher, MM; Hough, LB; Nalwalk, JW; Phillips, RS | 1 |
| Baroffio, M; Brusasco, V; Crimi, E; Rehder, K | 1 |
| Arttamangkul, S; Birdsong, WT; Cheng, K; Clark, MJ; Rice, KC; Traynor, JR; Williams, JT | 1 |
| Ingram, SL; Lamberts, JT; Li, MH; Neubig, RR; Smith, CE; Traynor, JR | 1 |
| Higgs, J; Loscalzo, LM; Marder, M; Wasowski, C | 1 |
| Becker, A; Grecksch, G; Havemann-Reinecke, U; Höllt, V; Maurer, HH; Meyer, MR; Neurath, H; Schröder, H; Stolt, AC; Ziebolz, N | 1 |
| Floros, TG; Johns, HW; Parker, KE; Will, MJ | 1 |
| Bailey, SJ; Casal-Dominguez, JJ; Clark, MJ; Furkert, D; Husbands, SM; Ostovar, M; Teintang, L; Traynor, JR | 1 |
| Cahill, CM; Olmstead, MC; Ong, EW; Xue, L | 1 |
| Chang, XM; Fang, Q; Han, ZL; Li, N; Li, XH; Pan, JX; Tang, HH; Wang, P; Wang, R; Wang, ZL; Zheng, T | 1 |
| Clissold, KA; Pratt, WE | 1 |
| Cetas, JS; Kronfeld, K; Liu, JJ; McFarlane, R; Raskin, JS; Smitasin, P | 1 |
| Booth, FW; Ruegsegger, GN; Toedebusch, RG; Will, MJ | 1 |
| Bullmore, ET; Maltby, K; Miller, SR; Mugnaini, M; Nathan, P; Ripley, TL; Sanchez-Roige, S; Stephens, DN; Wille, DR | 1 |
| Sirohi, S; Walker, BM | 1 |
| Booth, FW; Brown, JD; Kovarik, MC; Miller, DK; Ruegsegger, GN | 1 |
| Dziedowiec, E; Gruver, KS; Jennings, T; Nayak, SU; Rawls, SM; Tallarida, CS | 1 |
| Chai, JR; Dong, H; Huang, X; Liu, GY; Long, JD; Ma, Y; Wang, YH; Wang, YJ; Xiao, ZC; Xu, XJ; Ye, RF; Zan, GY | 1 |
| Lishmanov, YB; Madias, JE; Maslov, LN; Naryzhnaya, NV; Oeltgen, PR; Prokudina, ES; Tsibulnikov, SY | 1 |
| Araque, A; Corkrum, M; Kofuji, P; Rothwell, PE; Thomas, MJ | 1 |
| Annibale, P; Bock, A; Grushevskyi, EO; Heilemann, M; Isbilir, A; Karathanasis, C; Lohse, MJ; Möller, J; Osberg, B; Schütte, C; Sungkaworn, T; Sunkara, V | 1 |
359 other study(ies) available for naltrexone and enkephalin, ala(2)-mephe(4)-gly(5)-
| Article | Year |
|---|---|
Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors.
Topics: Analgesics; Animals; Binding Sites; Cell Line; CHO Cells; Cloning, Molecular; Cricetinae; Ligands; PC12 Cells; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Software | 1994 |
Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications.
Topics: Animals; Aorta, Thoracic; Cocaine; Cyclic AMP; Electric Stimulation; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Mice; Muscle, Smooth; Opioid-Related Disorders; Rats; Receptors, Dopamine; Receptors, Opioid; Receptors, Serotonin; Substance-Related Disorders | 1998 |
14-amino, 14-alkylamino, and 14-acylamino analogs of oxymorphindole. Differential effects on opioid receptor binding and functional profiles.
Topics: Analgesics, Opioid; Animals; Binding, Competitive; CHO Cells; Cricetinae; Morpholines; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, mu; Structure-Activity Relationship | 2003 |
Identification of opioid ligands possessing mixed micro agonist/delta antagonist activity among pyridomorphinans derived from naloxone, oxymorphone, and hydromorphone [correction of hydropmorphone].
Topics: Analgesics; Animals; Binding Sites; Brain; Drug Tolerance; Electric Stimulation; Guinea Pigs; Hydromorphone; Ileum; In Vitro Techniques; Ligands; Male; Mice; Mice, Inbred ICR; Morphinans; Muscle Contraction; Muscle, Smooth; Naloxone; Oxymorphone; Pyridines; Radioligand Assay; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Vas Deferens | 2004 |
Pharmacological properties of bivalent ligands containing butorphan linked to nalbuphine, naltrexone, and naloxone at mu, delta, and kappa opioid receptors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; CHO Cells; Cricetinae; Cricetulus; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Ligands; Morphinans; Nalbuphine; Naloxone; Naltrexone; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship | 2007 |
Endomorphin-2 with a beta-turn backbone constraint retains the potent micro-opioid receptor agonist properties.
Topics: Magnetic Resonance Spectroscopy; Models, Molecular; Oligopeptides; Protein Structure, Secondary; Receptors, Opioid, mu; Solutions; Stereoisomerism; Structure-Activity Relationship | 2008 |
Syntheses and opioid receptor binding properties of carboxamido-substituted opioids.
Topics: Amides; Analgesics, Opioid; Humans; Protein Binding; Receptors, Opioid; Structure-Activity Relationship; Tramadol | 2009 |
Design, synthesis, and biological evaluation of 6alpha- and 6beta-N-heterocyclic substituted naltrexamine derivatives as mu opioid receptor selective antagonists.
Topics: Amino Acid Sequence; Analgesics; Analgesics, Opioid; Animals; Binding Sites; Binding, Competitive; CHO Cells; Cricetinae; Cricetulus; Drug Design; Ligands; Models, Molecular; Molecular Sequence Data; Morphinans; Morphine; Naltrexone; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sequence Alignment; Structure-Activity Relationship | 2009 |
14-O-Heterocyclic-substituted naltrexone derivatives as non-peptide mu opioid receptor selective antagonists: design, synthesis, and biological studies.
Topics: Binding, Competitive; Chemistry, Pharmaceutical; Drug Design; Humans; Kinetics; Ligands; Molecular Conformation; Molecular Structure; Naltrexone; Narcotic Antagonists; Nitrogen; Peptides; Protein Structure, Tertiary; Receptors, Opioid, mu | 2009 |
Syntheses of novel high affinity ligands for opioid receptors.
Topics: Analgesics, Opioid; Crystallography, X-Ray; Furans; Humans; Ligands; Naltrexone; Narcotic Antagonists; Protein Binding; Receptors, Opioid | 2009 |
Synthesis and pharmacological evaluation of 6-naltrexamine analogs for alcohol cessation.
Topics: Alcohol Deterrents; Alcoholism; Animals; Humans; Liver; Male; Mice; Naltrexone; Nociceptin Receptor; Protein Binding; Rats; Rats, Wistar; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship | 2009 |
Generation of novel radiolabeled opiates through site-selective iodination.
Topics: Animals; Binding Sites; Binding, Competitive; CHO Cells; Cricetinae; Cricetulus; Humans; Iodine Radioisotopes; Molecular Structure; Neurotransmitter Agents; Oxymorphone; Radioligand Assay; Receptors, Opioid | 2011 |
Design, syntheses, and pharmacological characterization of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(isoquinoline-3'-carboxamido)morphinan analogues as opioid receptor ligands.
Topics: Animals; CHO Cells; Cricetulus; Drug Design; Humans; Isoquinolines; Ligands; Mice; Molecular Dynamics Simulation; Morphinans; Morphine Dependence; Narcotic Antagonists; Receptors, Opioid, mu; Structure-Activity Relationship | 2015 |
Synthesis, Biological Evaluation, and Utility of Fluorescent Ligands Targeting the μ-Opioid Receptor.
Topics: Animals; Binding, Competitive; Buprenorphine; CHO Cells; Cricetulus; Fluorescent Dyes; HEK293 Cells; Humans; Ligands; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Radioligand Assay; Receptors, Opioid, mu; Stereoisomerism; Structure-Activity Relationship | 2015 |
Kappa-/mu-receptor interactions in the opioid control of the in vivo release of substance P-like material from the rat spinal cord.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Kinetics; Male; Models, Neurological; Naloxone; Naltrexone; Pyrrolidines; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord; Substance P | 1992 |
A highly selective kappa-opioid receptor agonist, CI-977, reduces excitatory synaptic potentials in the rat locus coeruleus in vitro.
Topics: Amino Acids; Analgesics; Animals; Benzofurans; Benzomorphans; Bicuculline; Depression, Chemical; Electric Stimulation; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; In Vitro Techniques; Ligands; Locus Coeruleus; Membrane Potentials; Naloxone; Naltrexone; Picrotoxin; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Synapses | 1992 |
Kappa-opioid receptor stimulation abolishes mu- but not delta-mediated inhibitory control of spinal Met-enkephalin release.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Indoles; Injections, Spinal; Male; Morphinans; Naloxone; Naltrexone; Neurons; Oligopeptides; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1992 |
Effects of selective opioid receptor agonists and antagonists during myocardial ischaemia.
Topics: Animals; Arrhythmias, Cardiac; Coronary Disease; Coronary Vessels; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Hemodynamics; Male; Morphinans; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1992 |
Ex vivo determination of opiate antagonist binding at mu-opioid ([3H]-DAGO) receptors in hypothalamic micropunches from maturing female rats: comparison between SDZ 210-096 and nalmefene.
Topics: Age Factors; Animals; Animals, Newborn; Binding, Competitive; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Hypothalamus; Morphinans; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Sexual Maturation; Vagina | 1992 |
Opioid receptor antagonists discriminate between presynaptic mu and delta receptors and the adenylate cyclase-coupled opioid receptor complex in the brain.
Topics: Acetylcholine; Adenylyl Cyclases; Animals; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Indoles; Male; Morphinans; Naltrexone; Narcotic Antagonists; Norepinephrine; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu | 1992 |
Isobolographic and dose-response analyses of the interaction between intrathecal mu and delta agonists: effects of naltrindole and its benzofuran analog (NTB).
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Indoles; Injections, Spinal; Male; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu | 1992 |
Chronic d-amphetamine inhibits opioid receptor antagonist-induced supersensitivity.
Topics: Animals; Dextroamphetamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Mice; Morphine; Naltrexone; Receptors, Opioid; Up-Regulation | 1992 |
Opposing tonically active endogenous opioid systems modulate the mesolimbic dopaminergic pathway.
Topics: Analgesics; Animals; Benzeneacetamides; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Infusions, Parenteral; Limbic System; Male; Microinjections; Models, Neurological; Naltrexone; Nucleus Accumbens; Pyrrolidines; Rats; Rats, Inbred Strains; Somatostatin; Tegmentum Mesencephali | 1992 |
Combination of a delta opioid receptor agonist but not a mu opioid receptor agonist with the D1-selective dopamine receptor agonist SKF 38393 markedly potentiates different behaviors in mice.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Analysis of Variance; Animals; Behavior, Animal; Benzazepines; Dopamine Agents; Dopamine Antagonists; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Grooming; Indoles; Injections, Intraventricular; Male; Mice; Morphinans; Motor Activity; Naltrexone; Sulpiride | 1992 |
Activation of kappa-opioid receptors depresses electrically evoked excitatory postsynaptic potentials on 5-HT-sensitive neurones in the rat dorsal raphé nucleus in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Afferent Pathways; Animals; Benzofurans; Bicuculline; Bombesin; Cholecystokinin; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Evoked Potentials; Glutamates; Glutamic Acid; In Vitro Techniques; Kynurenic Acid; N-Methylaspartate; Naloxone; Naltrexone; Neurons; Picrotoxin; Prazosin; Pyrrolidines; Quinoxalines; Raphe Nuclei; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Serotonin; Synapses; Tetrodotoxin | 1992 |
Pharmacological profiles of fentanyl analogs at mu, delta and kappa opiate receptors.
Topics: Analgesics, Opioid; Animals; Benzeneacetamides; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fentanyl; Guinea Pigs; Ileum; Male; Mice; Naltrexone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vas Deferens | 1992 |
Tyr-MIF-1 and hemorphin can act as opiate agonists as well as antagonists in the guinea pig ileum.
Topics: Amino Acid Sequence; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Hemoglobins; Ileum; In Vitro Techniques; Male; Molecular Sequence Data; Morphine; MSH Release-Inhibiting Hormone; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists; Peptide Fragments; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1992 |
Alkylation with beta-funaltrexamine suggests differences between mu-opioid receptor systems in guinea-pig brain and myenteric-plexus.
Topics: Alkylating Agents; Alkylation; Animals; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; In Vitro Techniques; Male; Myenteric Plexus; Naltrexone; Receptors, Opioid, mu | 1991 |
Feedback inhibition of met-enkephalin release from the rat spinal cord in vivo.
Topics: Animals; Calcitonin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Feedback; Indoles; Injections, Spinal; Leucine; Male; Morphinans; Naloxone; Naltrexone; Oligopeptides; Radioimmunoassay; Rats; Rats, Inbred Strains; Spinal Cord; Thiorphan | 1992 |
Autoradiographic study of irreversible binding of [3H]beta-funaltrexamine to opioid receptors in the rat forebrain: comparison with mu and delta receptor distribution.
Topics: Animals; Autoradiography; Diencephalon; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Telencephalon; Tritium | 1991 |
Opioid delta agonists and endogenous enkephalins induce different emotional reactivity than mu agonists after injection in the rat ventral tegmental area.
Topics: Animals; Anxiety; Emotions; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Exploratory Behavior; Indoles; Injections; Male; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Tegmentum Mesencephali | 1991 |
Selective blockage of delta opioid receptors prevents the development of morphine tolerance and dependence in mice.
Topics: Animals; Drug Implants; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Indoles; Isothiocyanates; Male; Mice; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Nociceptors; Receptors, Opioid; Receptors, Opioid, delta; Substance-Related Disorders; Thiocyanates | 1991 |
Characteristics of dose-dependent antagonism by beta-funaltrexamine of the antinociceptive effects of intrathecal mu agonists.
Topics: Analgesics; Animals; Binding, Competitive; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fentanyl; Injections, Spinal; Male; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Spinal Cord; Sufentanil | 1991 |
Dissociation of opioid receptor upregulation and functional supersensitivity.
Topics: Analgesia; Animals; Binding Sites; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Kinetics; Male; Mice; Morphine; Naltrexone; Pertussis Toxin; Receptors, Opioid; Up-Regulation; Virulence Factors, Bordetella | 1991 |
Ventral pallidal microinjections of receptor-selective opioid agonists produce differential effects on circling and locomotor activity in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Functional Laterality; Globus Pallidus; Male; Microinjections; Motor Activity; Naltrexone; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stereotyped Behavior; Time Factors | 1991 |
Delta receptor involvement in morphine suppression of noxiously evoked activity of spinal WDR neurons in cats.
Topics: Analgesia; Animals; Cats; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Evoked Potentials; Female; Hot Temperature; Injections, Spinal; Male; Morphine; Naltrexone; Narcotic Antagonists; Neurons; Pain; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord | 1991 |
Selective antagonism by naltrindole of the antinociceptive effects of the delta opioid agonist cyclic[D-penicillamine2-D-penicillamine5]enkephalin in the rat.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Indoles; Injections, Spinal; Injections, Subcutaneous; Male; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Nociceptors; Pain Measurement; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord | 1991 |
Cross-tolerance studies in the spinal cord of beta-FNA-treated mice provides further evidence for delta opioid receptor subtypes.
Topics: Animals; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Spinal; Male; Mice; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord | 1991 |
DAGO ([D-Ala2,N-Me-Phe4,Gly-ol]enkephalin) specifically reverses apomorphine-induced increase in rearing and grooming behaviors in the mouse.
Topics: Animals; Apomorphine; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Grooming; Injections, Intraventricular; Mice; Mice, Inbred Strains; Motor Activity; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, mu | 1991 |
Beta-funaltrexamine (beta-FNA) decreases deprivation and opioid-induced feeding.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Feeding Behavior; Food Deprivation; Injections, Intraventricular; Male; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa | 1991 |
Modulation of mu-mediated antitussive activity in rats by a delta agonist.
Topics: Aerosols; Animals; Antitussive Agents; Capsaicin; Cisterna Magna; Cough; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Indoles; Injections; Male; Morphinans; Morphine; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1991 |
Effects of intracerebroventricular beta-funaltrexamine on mu and delta opioid receptors in the rat: dichotomy between binding and antinociception.
Topics: Animals; Brain; Cerebral Cortex; Corpus Striatum; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intravenous; Kinetics; Male; Morphine; Naltrexone; Narcotic Antagonists; Nociceptors; Periaqueductal Gray; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Thalamus; Time Factors; Tritium | 1991 |
Naltrexone-sensitizing effects of centrally administered morphine and opioid peptides.
Topics: Animals; Conditioning, Operant; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Morphine; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta | 1991 |
mu-receptor mediates elevated glucose and corticosterone after third ventricle injection of opioid peptides.
Topics: Animals; beta-Endorphin; Blood Glucose; Cerebral Ventricles; Corticosterone; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Fatty Acids, Nonesterified; Injections, Intraventricular; Male; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu | 1991 |
Effect of opioid receptor antagonists on vasodilator nerve actions in the perfused rat mesentery.
Topics: Animals; Calcitonin Gene-Related Peptide; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Guanethidine; In Vitro Techniques; Male; Mesenteric Arteries; Methoxamine; Muscle, Smooth, Vascular; Naloxone; Naltrexone; Narcotic Antagonists; Neurons, Afferent; Perfusion; Rats; Rats, Inbred Strains; Somatostatin; Vasodilation | 1991 |
[D-Ala2,NMePhe4,Gly-ol5]enkephalin, but not [D-Pen2,L-Pen5]enkephalin, specifically inhibits behaviors induced by the dopamine D2 agonist RU 24213.
Topics: Analysis of Variance; Animals; Behavior, Animal; Dopamine Agents; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Motor Activity; Naltrexone; Phenethylamines | 1991 |
Voltage-clamp experiments reveal receptor type-dependent modulation of chloride secretion in the guinea pig colonic mucosa by intestinal opioids.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Alprostadil; Amiloride; Amino Acid Sequence; Analgesics; Animals; Benzeneacetamides; Chlorides; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Gluconates; Guinea Pigs; Intestinal Mucosa; Male; Membrane Potentials; Molecular Sequence Data; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin; Tetrodotoxin; Theophylline | 1991 |
Activation of mu opioid receptors inhibits transient high- and low-threshold Ca2+ currents, but spares a sustained current.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Sequence; Animals; Calcium Channels; Cells, Cultured; Electric Conductivity; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Molecular Sequence Data; Mollusk Venoms; Naltrexone; Narcotic Antagonists; omega-Conotoxin GVIA; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1991 |
Systemic administration of (Tyr-D-Ser(O-tert-butyl)-Gly-Phe-Leu-Thr(O-tert-butyl), a highly selective delta opioid agonist, induces mu receptor-mediated analgesia in mice.
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Indoles; Injections, Intravenous; Male; Mice; Morphinans; Naltrexone; Narcotic Antagonists; Oligopeptides; Receptors, Opioid; Receptors, Opioid, mu | 1991 |
Comparison of naloxonazine and beta-funaltrexamine antagonism of mu 1 and mu 2 opioid actions.
Topics: Animals; Drug Administration Schedule; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Subcutaneous; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, mu | 1991 |
Sympathoadrenal control by paraventricular hypothalamic beta-endorphin in hypertension.
Topics: Animals; Behavior, Animal; beta-Endorphin; Blood Glucose; Blood Pressure; Catecholamines; Diffusion; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Heart Rate; Hypertension; Male; Naltrexone; Paraventricular Hypothalamic Nucleus; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 1991 |
Pretreatment of rats with the irreversible mu-receptor antagonist, beta-FNA, fails to prevent naltrexone-induced upregulation of mu-opioid receptors.
Topics: Animals; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; In Vitro Techniques; Isothiocyanates; Kinetics; Naltrexone; Narcotic Antagonists; Oxymorphone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Thiocyanates; Up-Regulation | 1990 |
Nor-binaltorphimine decreases deprivation and opioid-induced feeding.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Feeding Behavior; Food Deprivation; Male; Naltrexone; Oligopeptides; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Reference Values | 1990 |
Pharmacologic profile of NPC 168 (naltrexone phenyl oxime), a novel compound with activity at opioid receptors.
Topics: Animals; Binding, Competitive; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Food Deprivation; Guinea Pigs; Injections, Intraventricular; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Reaction Time; Reinforcement Schedule | 1990 |
Characterisation of opioid binding sites using selective antagonists.
Topics: Animals; Binding, Competitive; Brain; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; In Vitro Techniques; Indoles; Morphinans; Naltrexone; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Somatostatin | 1990 |
Tonic opioid inhibition of the pressor region of the rostral ventrolateral medulla of rabbits is mediated by delta receptors.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Glutamates; Glutamic Acid; Hemodynamics; Male; Medulla Oblongata; Microinjections; Naltrexone; Narcotic Antagonists; Pressoreceptors; Rabbits; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1990 |
The selectivity of the opioid antagonist, naltrindole, for delta-opioid receptors.
Topics: Animals; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guanylyl Imidodiphosphate; Guinea Pigs; In Vitro Techniques; Indoles; Male; Mice; Mice, Inbred Strains; Morphinans; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sodium; Vas Deferens | 1990 |
Delta opioid antagonist, naltrindole, selectively blocks analgesia induced by DPDPE but not DAGO or morphine.
Topics: Analgesia; Analgesics; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Indoles; Injections, Intraventricular; Male; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Reaction Time; Restraint, Physical; Stress, Psychological | 1991 |
Conjugate addition ligands of opioid antagonists. Methacrylate esters and ethers of 6 alpha- and 6 beta-naltrexol.
Topics: Animals; Benzomorphans; Binding, Competitive; Cattle; Caudate Nucleus; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Esters; Ethers; In Vitro Techniques; Ligands; Methacrylates; Naltrexone; Receptors, Opioid; Structure-Activity Relationship | 1990 |
[3H] beta-funaltrexamine ([3H] beta-FNA) binds irreversibly to mu opioid receptors in the rat brain: autoradiographic study.
Topics: Animals; Autoradiography; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Male; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1990 |
Opioid receptor-mediated inhibition of dopamine and acetylcholine release from slices of rat nucleus accumbens, olfactory tubercle and frontal cortex.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetylcholine; Animals; Benzomorphans; Cerebral Cortex; Corpus Striatum; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ergolines; In Vitro Techniques; Male; Naloxone; Naltrexone; Nucleus Accumbens; Olfactory Bulb; Oxymetazoline; Pyrrolidines; Quinpirole; Rats; Rats, Inbred Strains; Receptors, Opioid; Septal Nuclei | 1990 |
Stereoselectivity and subtype of the opiate receptor involved in stress-induced hypertension.
Topics: Animals; Blood Pressure; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Hypertension; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Social Isolation; Stereoisomerism; Stress, Psychological | 1990 |
Modulation of opioid receptor binding by cis and trans fatty acids.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fatty Acids; Guanosine 5'-O-(3-Thiotriphosphate); Male; Naltrexone; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Stereoisomerism | 1990 |
Simultaneous development of opioid tolerance and opioid antagonist-induced receptor upregulation.
Topics: Analgesia; Animals; Brain; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Kinetics; Male; Mice; Morphine; Naloxone; Naltrexone; Pain; Receptors, Opioid; Reference Values; Up-Regulation | 1990 |
Selective kappa antagonist properties of nor-binaltorphimine in the rat MES seizure model.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Anticonvulsants; Electroshock; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Naltrexone; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Seizures | 1989 |
Opioid antagonist modulation of murine neuroblastoma: a profile of cell proliferation and opioid peptides and receptors.
Topics: Animals; Cell Division; Cell Line; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Mice; Naltrexone; Neoplasms, Experimental; Neuroblastoma; Receptors, Opioid | 1989 |
Chronic administration of morphine and naltrexone up-regulate mu-opioid binding sites labeled by [3H][D-Ala2,MePhe4,Gly-ol5]enkephalin: further evidence for two mu-binding sites.
Topics: Animals; Benzomorphans; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; In Vitro Techniques; Male; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1989 |
Up-regulation of opiate receptors following chronic naltrexone treatment in mature and aged male and female rats.
Topics: Aging; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Male; Naltrexone; Rats; Rats, Inbred F344; Receptors, Opioid | 1989 |
A mu-specific opioid peptide agonist increases excitability of pyramidal neurons in untreated and receptor up-regulated hippocampus.
Topics: Action Potentials; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hippocampus; In Vitro Techniques; Male; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Up-Regulation | 1989 |
Role of central opiate receptor subtypes in the circulatory responses of awake rabbits to graded caval occlusions.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Blood Circulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Hemodynamics; Hemorrhage; Naloxone; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rabbits; Receptors, Opioid; Vena Cava, Inferior | 1989 |
Evidence for the presence of disulfide bridges in opioid receptors essential for ligand binding. Possible role in receptor activation.
Topics: Animals; Brain; Cattle; Cell Membrane; Chemical Phenomena; Chemistry; Disulfides; Dithiothreitol; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Ligands; Molecular Weight; Naltrexone; Receptors, Opioid | 1989 |
Intracerebroventricular N-ethylmaleimide differentially reduces supraspinal opioid analgesia in mice.
Topics: Analgesics; Animals; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylmaleimide; Injections, Intraventricular; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Sulfhydryl Reagents | 1989 |
Opioid delta-receptor involvement in supraspinal and spinal antinociception in mice.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Drug Combinations; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Hot Temperature; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Nociceptors; Pain; Receptors, Opioid; Receptors, Opioid, delta; Spinal Cord | 1987 |
Cellular mechanisms of opioid tolerance: studies in single brain neurons.
Topics: Animals; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; In Vitro Techniques; Locus Coeruleus; Male; Membrane Potentials; Morphine; Morphine Derivatives; Naltrexone; Neurons; Potassium; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu | 1987 |
Roles of central and peripheral mu, delta and kappa opioid receptors in the mediation of gastric acid secretory effects in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Brain; Cyclazocine; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; Gastric Acid; Male; Morphine; Naltrexone; Pyrrolidines; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1988 |
Effect of ethanol on the binding of conformationally rigid and labile ligands of opioid receptors to rat brain membranes.
Topics: Animals; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethanol; In Vitro Techniques; Male; Naltrexone; Oligopeptides; Protein Conformation; Rats; Rats, Inbred Strains; Receptors, Opioid | 1988 |
Nor-binaltorphimine, a highly selective kappa-opioid antagonist in analgesic and receptor binding assays.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Guinea Pigs; Male; Mice; Morphine; Naltrexone; Oligopeptides; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa | 1988 |
Kappa receptor regulation of dopamine release from striatum and cortex of rats and guinea pigs.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cerebral Cortex; Corpus Striatum; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Male; Naltrexone; Potassium; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa | 1988 |
beta-FNA binds irreversibly to the opiate receptor complex: in vivo and in vitro evidence.
Topics: Animals; Binding Sites; Binding, Competitive; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Injections, Intraventricular; Male; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1988 |
Estimation of opioid receptor agonist dissociation constants with beta-chlornaltrexamine, an irreversible ligand which also displays agonism.
Topics: Animals; Cyclazocine; Drug Interactions; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Ethylketocyclazocine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphinans; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1988 |
Influence of neonatal opioid blockade or injections of gonadotrophin-releasing hormone on the timing of puberty in female rats: correlation of opioid effects with occupation of hypothalamic mu-opioid receptors.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Hypothalamus; Naloxone; Naltrexone; Pituitary Hormone-Releasing Hormones; Rats; Receptors, Opioid; Receptors, Opioid, mu; Sexual Maturation; Time Factors | 1988 |
Lack of evidence for epsilon-opioid receptors in the rat vas deferens.
Topics: Animals; Calcium; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; In Vitro Techniques; Male; Muscle Contraction; Naloxone; Naltrexone; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Vas Deferens | 1988 |
Effects of beta-chlornaltrexamine on food intake, body weight and opioid-induced feeding.
Topics: Animals; Body Weight; Dynorphins; Eating; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Male; Naltrexone; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid | 1987 |
An examination of the opiate receptor subtypes labeled by [3H]cycloFOXY: an opiate antagonist suitable for positron emission tomography.
Topics: Animals; Autoradiography; Brain; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Naloxone; Naltrexone; Peptide Fragments; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Synaptic Membranes; Tomography, Emission-Computed | 1988 |
Behavioral effects of opioid peptides selective for mu or delta receptors. I. Morphine-like discriminative stimulus effects.
Topics: Animals; beta-Endorphin; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Discrimination Learning; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Morphine; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1986 |
Behavioral effects of opioid peptides selective for mu or delta receptors. II. Locomotor activity in nondependent and morphine-dependent rats.
Topics: Animals; beta-Endorphin; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Morphine Dependence; Motor Activity; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1986 |
Pharmacodynamic supersensitivity and opioid receptor upregulation in the mouse.
Topics: Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Lethal Dose 50; Male; Mice; Morphine; Naltrexone; Receptors, Opioid; Time Factors | 1986 |
Irreversible selective blockade of kappa-opioid receptors in the guinea-pig ileum.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Diuresis; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine Derivatives; Naltrexone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa | 1986 |
Reversible and irreversible binding of beta-funaltrexamine to mu, delta and kappa opioid receptors in guinea pig brain membranes.
Topics: Animals; Brain; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Ethylmaleimide; Guinea Pigs; Kinetics; Male; Membranes; Naloxone; Naltrexone; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sodium Chloride | 1986 |
Evidence for mu opioid receptor mediation of enkephalin-induced electroencephalographic seizures.
Topics: Animals; Electroencephalography; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Naloxone; Naltrexone; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Seizures | 1987 |
Delta receptors in the rat vas deferens.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; In Vitro Techniques; Male; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Vas Deferens | 1986 |
Enkephalin release into the ventral tegmental area in response to stress: modulation of mesocorticolimbic dopamine.
Topics: Animals; Dopamine; Electroshock; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Frontal Lobe; Male; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Septal Nuclei; Stress, Physiological; Tegmentum Mesencephali | 1987 |
Reversible modulation of opioid receptor binding in intact neural cells by endogenous guanosine triphosphate.
Topics: Adenylyl Cyclases; Amino Acid Sequence; Analgesics; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; GTP-Binding Proteins; Guanosine Triphosphate; Humans; Kinetics; Molecular Sequence Data; Mycophenolic Acid; Naltrexone; Narcotic Antagonists; Neuroblastoma; Neurons; Receptors, Opioid, mu; Tritium; Tumor Cells, Cultured | 1995 |
Characterization of the opioid receptor subtypes mediating the negative inotropic effects of DAMGO, DPDPE and U-50, 488H in isolated human right atria strips.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adult; Aged; Analgesics; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Heart Atria; Humans; Male; Middle Aged; Myocardial Contraction; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pyrrolidines; Receptors, Opioid | 1995 |
Opioid mu- and kappa-receptor mediate phospholipase C activation through Gi1 in Xenopus oocytes.
Topics: Animals; Benzeneacetamides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Enzyme Activation; Female; GTP-Binding Proteins; Naltrexone; Oocytes; Pyrrolidines; Receptors, Opioid, kappa; Receptors, Opioid, mu; Type C Phospholipases; Xenopus laevis | 1995 |
Species and age-dependent differences of functional coupling between opioid delta-receptor and G-proteins and possible involvement of protein kinase C in striatal membranes.
Topics: Aging; Analgesics; Animals; Carbazoles; Cell Membrane; Corpus Striatum; Cyclic AMP-Dependent Protein Kinases; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; GTP Phosphohydrolases; GTP-Binding Proteins; Guinea Pigs; Indoles; Kinetics; Male; Naltrexone; Naphthalenes; Polycyclic Compounds; Protein Kinase C; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Species Specificity | 1994 |
Opioids and nitric oxide contribute to hypoxia-induced pial arterial vasodilation in newborn pigs.
Topics: Amino Acid Oxidoreductases; Analysis of Variance; Animals; Animals, Newborn; Arginine; Arterioles; Cerebral Arteries; Cyclic GMP; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Female; Hypoxia; Male; Muscle, Smooth, Vascular; Naltrexone; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Nitroprusside; Receptors, Opioid, kappa; Receptors, Opioid, mu; Swine; Vasodilation | 1995 |
Inflammation enhances peripheral mu-opioid receptor-mediated analgesia, but not mu-opioid receptor transcription in dorsal root ganglia.
Topics: Amino Acid Sequence; Analgesia; Analgesics; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Foot; Ganglia, Spinal; Inflammation; Male; Molecular Sequence Data; Naltrexone; Narcotic Antagonists; Pain Measurement; Rats; Rats, Wistar; Receptors, Opioid, mu; Ribonucleases; RNA, Messenger | 1995 |
Antinociception and delta-1 opioid receptors in the rat spinal cord: studies with intrathecal 7-benzylidenenaltrexone.
Topics: Analgesics; Animals; Benzylidene Compounds; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Spinal; Male; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Spinal Cord | 1995 |
Effects of mu opioid agonist and antagonist on neurological outcome following traumatic brain injury in the rat.
Topics: Animals; Brain Injuries; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Naltrexone; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Treatment Outcome | 1995 |
Inhibition of luteinizing hormone-releasing hormone secretion by delta-opioid agonists in GT1-1 neuronal cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Alprostadil; Amino Acid Sequence; Cell Line; Colforsin; Culture Media, Conditioned; Dinoprostone; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gonadotropin-Releasing Hormone; Molecular Sequence Data; Naltrexone; Narcotic Antagonists; Neurons; Pyrrolidines; Receptors, Opioid, delta | 1995 |
mu- and delta-opioid receptor-mediated contractile effects on rat aortic vascular smooth muscle.
Topics: Amino Acid Sequence; Analgesics; Analysis of Variance; Animals; Aorta; Benzomorphans; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Molecular Sequence Data; Morphine; Muscle Contraction; Muscle, Smooth, Vascular; Naltrexone; Norepinephrine; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu | 1995 |
Modification of mu-opioid agonist-induced locomotor activity and development of morphine dependence by diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Mice; Mice, Inbred ICR; Morphine; Morphine Dependence; Motor Activity; Naloxone; Naltrexone; Receptors, Opioid, mu; Streptozocin | 1995 |
The modulation of placental lactogen release by opioids: a role for extracellular calcium.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylate Cyclase Toxin; Analgesics; Calcium; Cells, Cultured; Dopamine; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Ethylketocyclazocine; Gene Expression Regulation; Humans; Ionomycin; Naloxone; Naltrexone; Narcotics; Pertussis Toxin; Placental Lactogen; Pyrrolidines; Time Factors; Trophoblasts; Virulence Factors, Bordetella | 1993 |
Expression of functional delta opioid receptors in Xenopus oocytes.
Topics: Adenylyl Cyclases; Analgesics; Analysis of Variance; Animals; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Female; Glioma; Hybrid Cells; Isoproterenol; Mice; Naltrexone; Neuroblastoma; Oocytes; Poly A; Rats; Receptors, Opioid, delta; RNA; RNA, Messenger; Xenopus laevis | 1993 |
Differential involvement of ventral tegmental mu, delta and kappa opioid receptors in modulation of basal mesolimbic dopamine release: in vivo microdialysis studies.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; 3,4-Dihydroxyphenylacetic Acid; Amino Acid Sequence; Analgesics; Animals; Chromatography, High Pressure Liquid; Corpus Striatum; Dialysis; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Homovanillic Acid; Hydroxyindoleacetic Acid; Limbic System; Male; Microinjections; Molecular Sequence Data; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Tegmentum Mesencephali | 1993 |
Activation of mu-opioid receptor modulates GABAA receptor-mediated currents in isolated spinal dorsal horn neurons.
Topics: Action Potentials; Amino Acid Sequence; Animals; Bicuculline; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Molecular Sequence Data; Muscimol; Naloxone; Naltrexone; Neurons, Afferent; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Opioid, mu; Spinal Cord | 1994 |
Opioid effects on spinal [3H]5-hydroxytryptamine release are not related to their antinociceptive action.
Topics: Amino Acid Sequence; Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Isotope Labeling; Male; Molecular Sequence Data; Naltrexone; Narcotics; Potassium; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Serotonin; Somatostatin; Spinal Cord; Synaptic Transmission; Synaptosomes | 1995 |
A lack of supersensitivity to opioid receptor agonists following chronic spinal opioid receptor antagonist administration in the rat.
Topics: Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Somatostatin; Species Specificity; Spinal Cord | 1995 |
kappa-Opioid receptor activates an inwardly rectifying K+ channel by a G protein-linked mechanism: coexpression in Xenopus oocytes.
Topics: Animals; Benzeneacetamides; Cloning, Molecular; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Gene Expression; GTP-Binding Proteins; In Vitro Techniques; Mice; Naloxone; Naltrexone; Oocytes; Pertussis Toxin; Potassium Channels; Pyrrolidines; Receptors, Opioid, kappa; RNA, Complementary; Virulence Factors, Bordetella; Xenopus | 1995 |
Kappa opioid receptor agonists suppress absence seizures in WAG/Rij rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Sequence; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electroencephalography; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Epilepsy, Absence; Injections, Intraventricular; Injections, Subcutaneous; Male; Molecular Sequence Data; Naltrexone; Pyrroles; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid, kappa; Receptors, Opioid, mu; Thiophenes | 1995 |
Effect of intracerebroventricular beta-funaltrexamine on mu opioid receptors in the rat brain: consideration of binding condition.
Topics: Analgesics; Animals; Binding, Competitive; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Tritium | 1995 |
Characterisation of mu-opioid receptors on SH-SY5Y cells using naloxonazine and beta-funaltrexamine.
Topics: Amino Acid Sequence; Animals; Brain Neoplasms; Cerebral Cortex; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Humans; Ligands; Molecular Sequence Data; Naloxone; Naltrexone; Neuroblastoma; Rats; Receptors, Opioid, mu; Somatostatin; Tumor Cells, Cultured | 1994 |
Evidence that nor-binaltorphimine can function as an antagonist at multiple opioid receptor subtypes.
Topics: Amino Acid Sequence; Analgesics; Animals; Benzeneacetamides; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Injections, Intraventricular; Male; Molecular Sequence Data; Naltrexone; Narcotic Antagonists; Pain; Pain Threshold; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Somatostatin | 1994 |
The effect of chronic treatment with naltrindole, a selective delta-opioid antagonist, on mu-opioid receptor-mediated antinociception in diabetic mice.
Topics: Analgesics; Animals; Diabetes Mellitus, Experimental; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intraventricular; Injections, Subcutaneous; Male; Mice; Mice, Inbred ICR; Monocytes; Morphine; Naltrexone; Narcotic Antagonists; Pain Measurement; Receptors, Opioid, delta; Receptors, Opioid, mu; Spleen | 1993 |
Long-term sensitization to the behavioral effects of naltrexone is associated with regionally specific changes in the number of mu and delta opioid receptors in rat brain.
Topics: Animals; Behavior, Animal; Brain; Cerebral Cortex; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mesencephalon; Naltrexone; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Rhombencephalon; Salivation; Tritium | 1995 |
Alkylation of mu opioid receptors by beta-funaltrexamine in vivo: comparison of the effects on in situ binding and heroin self-administration in rats.
Topics: Alkylation; Animals; Behavior, Animal; Binding, Competitive; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Heroin; In Vitro Techniques; Injections, Intraventricular; Naltrexone; Rats; Rats, Inbred F344; Receptors, Opioid, mu; Self Administration | 1995 |
Influence of hypertension development on rat tail artery responses to opioid peptides.
Topics: Age Factors; Animals; Dose-Response Relationship, Drug; Dynorphins; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Hypertension; In Vitro Techniques; Male; Naltrexone; Narcotic Antagonists; Phenylephrine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; Receptors, Opioid; Tail; Vasoconstriction | 1995 |
Differential regulation of adenylyl cyclase activity by mu and delta opioids in rat caudate putamen and nucleus accumbens.
Topics: Adenylyl Cyclases; Amino Acid Sequence; Animals; Benzeneacetamides; Caudate Nucleus; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Male; Molecular Sequence Data; Naloxone; Naltrexone; Nucleus Accumbens; Oligopeptides; Putamen; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Signal Transduction; Somatostatin | 1993 |
Effects of mu, delta and kappa opioid antagonists on the depression of a C-fiber reflex by intrathecal morphine and DAGO in the rat.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Spinal; Morphine; Naltrexone; Narcotic Antagonists; Nerve Fibers; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reflex; Somatostatin | 1994 |
Semiparametric models for antagonistic drug interactions.
Topics: Animals; Binding, Competitive; Drug Antagonism; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intraventricular; Models, Biological; Naltrexone; Narcotic Antagonists; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Somatostatin | 1994 |
The kappa agonist fedotozine modulates colonic distention-induced inhibition of gastric motility and emptying in dogs.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzyl Compounds; Bretylium Compounds; Catheterization; Colon; Dogs; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Gastric Emptying; Gastrointestinal Motility; Granisetron; Hexamethonium; Male; Naltrexone; Narcotic Antagonists; Propylamines; Pyrrolidines; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reflex; Stomach | 1994 |
Opioid peptides selective for receptor types modulate cocaine-induced behavioral responses in mice.
Topics: Animals; Behavior, Animal; Cocaine; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Naltrexone; Opioid Peptides | 1994 |
Differential modulation of behavioral responses by [D-Ala2, NMePhe4, Gly-ol]enkephalin, [D-Ala2] deltorphin II and [D-Pen2, L-Pen5]enkephalin in the mouse.
Topics: Analysis of Variance; Animals; Behavior, Animal; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Mice, Inbred Strains; Naltrexone; Oligopeptides | 1994 |
Irreversible opioid antagonist effects of clocinnamox on opioid analgesia and mu receptor binding in mice.
Topics: Analgesia; Animals; Benzimidazoles; Cinnamates; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Mice; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu | 1994 |
Morphine reduces the release of met-enkephalin-like material from the rat spinal cord in vivo by acting at delta opioid receptors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Injections, Spinal; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pyrrolidines; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Spinal Cord | 1994 |
Beta-funaltrexamine blockade of opioid-induced inhibition of somatostatin secretion from rat stomach.
Topics: Amino Acid Sequence; Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Gastric Inhibitory Polypeptide; Gastric Mucosa; In Vitro Techniques; Male; Molecular Sequence Data; Naloxone; Naltrexone; Narcotic Antagonists; Radioimmunoassay; Rats; Rats, Wistar; Somatostatin | 1994 |
The effects of protection by D-Pen2-D-Pen5-enkephalin or D-Ala2-NMePhe4-Gly-ol-enkephalin against beta-chlornaltrexamine in the spinal cord on the antinociception induced by beta-endorphin administered intracerebroventricularly in the mouse.
Topics: Amino Acid Sequence; Analgesics; Animals; beta-Endorphin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Molecular Sequence Data; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Spinal Cord | 1994 |
Role of endogenous cholecystokinin in the facilitation of mu-mediated antinociception by delta-opioid agonists.
Topics: Amino Acid Sequence; Analgesia; Animals; Benzodiazepinones; Cholecystokinin; Devazepide; Disulfides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Mice; Molecular Sequence Data; Naloxone; Naltrexone; Oligopeptides; Peptide Fragments; Phenylalanine; Receptors, Opioid, delta; Receptors, Opioid, mu; Sincalide | 1994 |
Effect of morphine tolerance and abstinence on the binding of [3H]naltrexone to discrete brain regions and spinal cord of the rat.
Topics: Analgesics; Animals; Brain; Drug Implants; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Membranes; Morphine; Morphine Dependence; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, mu; Spinal Cord; Substance Withdrawal Syndrome | 1994 |
TRIMU-5, a mu 2-opioid receptor agonist, stimulates the hypothalamo-pituitary-adrenal axis.
Topics: Animals; Corticosterone; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hypothalamo-Hypophyseal System; Kinetics; Male; Naloxone; Naltrexone; Oligopeptides; Pituitary-Adrenal System; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 1994 |
Effect of chronic exposure to naltrexone and opioid selective agonists on G protein mRNA levels in the rat nervous system.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Brain; Cerebral Ventricles; Drug Administration Schedule; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Gene Expression; GTP-Binding Proteins; In Situ Hybridization; Infusions, Parenteral; Male; Naltrexone; Narcotics; Oligonucleotide Probes; Organ Specificity; Pyrrolidines; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1994 |
The use of specific opioid agonists and antagonists to delineate the vagally mediated antinociceptive and cardiovascular effects of intravenous morphine.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analysis of Variance; Animals; Blood Pressure; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Heart Rate; Hexamethonium; Hexamethonium Compounds; Indoles; Injections, Intravenous; Male; Morphinans; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pain; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reference Values; Time Factors; Vagotomy; Vagus Nerve | 1993 |
Effects of naltrexone on the binding of [3H]D-Ala2, MePhe4, Gly-ol5-enkephalin to brain regions and spinal cord and pharmacological responses to morphine in the rat.
Topics: Analgesics; Animals; Body Temperature; Brain; Drug Implants; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Morphine; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Spinal Cord; Up-Regulation | 1993 |
Delta-1 opioid agonist acutely increases hypoxic tolerance.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adaptation, Physiological; Animals; Benzylidene Compounds; Body Temperature; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hypoxia; Male; Mice; Naltrexone; Pyrrolidines; Receptors, Opioid, delta | 1994 |
Activation of spinal delta-1 or delta-2 opioid receptors reduces carrageenan-induced hyperalgesia in the rat.
Topics: Animals; Carrageenan; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hyperalgesia; Male; Naltrexone; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Spinal Cord | 1994 |
Opioids regulation of human chorionic gonadotropin release from trophoblast tissue is mediated by gonadotropin releasing hormone.
Topics: Chorionic Gonadotropin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Gonadotropin-Releasing Hormone; Humans; In Vitro Techniques; Naltrexone; Narcotics; Pregnancy; Receptors, Opioid, kappa; Trophoblasts | 1994 |
The nature of conditioned anti-analgesia: spinal cord opiate and anti-opiate neurochemistry.
Topics: Analgesia; Analgesics; Animals; Conditioning, Classical; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Immune Sera; Injections, Spinal; Male; Morphine; Naltrexone; Narcotic Antagonists; Oligopeptides; Proglumide; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Spinal Cord | 1994 |
Characterization of the mu-opioid receptors on SH-SY5Y cells using beta-funaltrexamine (beta-FNA) and naloxonazine.
Topics: Analgesics; Cell Line; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Humans; Kinetics; Naloxone; Naltrexone; Narcotic Antagonists; Neuroblastoma; Receptors, Opioid, mu; Tumor Cells, Cultured | 1993 |
Interactions between delta 9-tetrahydrocannabinol and kappa opioids in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzofurans; Dronabinol; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Mice, Inbred ICR; Naltrexone; Pyrrolidines; Receptors, Opioid, kappa | 1994 |
Area tempestas modulates the behavioural responses to nociceptive stimuli in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Anticonvulsants; Azocines; Bicuculline; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Escape Reaction; Foot; Hot Temperature; Male; Morphine; Naltrexone; Narcotic Antagonists; Olfactory Pathways; Pain; Phenazocine; Pressure; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid; Seizures; Tail | 1993 |
Delta opioid receptor mediates phospholipase C activation via Gi in Xenopus oocytes.
Topics: Analgesics; Animals; Benzeneacetamides; Electric Conductivity; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Enzyme Activation; Female; Gene Expression; GTP-Binding Proteins; Membrane Potentials; Mice; Naltrexone; Narcotic Antagonists; Oocytes; Pyrrolidines; Receptors, Opioid, delta; Type C Phospholipases; Xenopus laevis | 1993 |
Interacting presynaptic kappa-opioid and GABAA receptors modulate dopamine release from rat striatal synaptosomes.
Topics: Analysis of Variance; Animals; Benzeneacetamides; Bicuculline; Corpus Striatum; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; gamma-Aminobutyric Acid; Kinetics; Male; Naltrexone; Narcotics; Oligopeptides; Picrotoxin; Potassium; Pyrrolidines; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, Opioid, kappa; Synaptosomes | 1993 |
Naltrexone-induced upregulation of mu opioid receptors on 7315c cell and brain membranes: enhancement of opioid efficacy in inhibiting adenylyl cyclase.
Topics: Adenylyl Cyclases; Animals; Brain; Cell Membrane; Colforsin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Enzyme Activation; Guanosine 5'-O-(3-Thiotriphosphate); Naltrexone; Rats; Receptors, Opioid, mu; Tumor Cells, Cultured; Up-Regulation | 1993 |
Effects of intracerebroventricular administration of beta-funaltrexamine on [3H]DAMGO binding to rat brain sections.
Topics: Animals; Autoradiography; Brain Mapping; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Injections, Intraventricular; Male; Naltrexone; Rats; Rats, Inbred F344; Receptors, Opioid, mu | 1993 |
Binding in vivo of selective mu and delta opioid agonists: localization by autoradiography.
Topics: Amino Acid Sequence; Analgesics; Animals; Autoradiography; Binding, Competitive; Brain; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Diffusion; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intraventricular; Male; Mice; Molecular Sequence Data; Naltrexone; Oligopeptides; Pain Measurement; Protein Binding; Receptors, Opioid, delta; Receptors, Opioid, mu | 1993 |
Opioid antagonist-induced receptor upregulation: effects of concurrent agonist administration.
Topics: Animals; Brain; Drug Combinations; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Fentanyl; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu; Up-Regulation | 1994 |
DAMGO ([D-Ala2,NMePhe4,Gly-ol]enkephalin), but not DPLPE ([D-Pen2,L- Pen5]enkephalin), specifically inhibits methamphetamine-induced behavioral responses in the mouse.
Topics: Analgesics; Animals; Behavior, Animal; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Methamphetamine; Mice; Mice, Inbred Strains; Naltrexone; Narcotic Antagonists | 1993 |
Modification of morphine-induced locomotor activity by pertussis toxin: biochemical and behavioral studies in mice.
Topics: Analgesics; Analysis of Variance; Animals; Cerebral Ventricles; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intraventricular; Injections, Subcutaneous; Kinetics; Male; Mice; Mice, Inbred Strains; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Pertussis Toxin; Time Factors; Virulence Factors, Bordetella | 1993 |
Effect of diabetes on the antinociceptive effect of beta-endorphin.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; beta-Endorphin; Cerebral Ventricles; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Pain; Pyrrolidines; Reference Values | 1993 |
Opioid agonist properties of two oxime derivatives of naltrexone, NPC 831 and NPC 836.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetates; Analgesics; Animals; Binding, Competitive; Bombesin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Ligands; Male; Mice; Naltrexone; Oximes; Pain; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid; Receptors, Opioid, kappa | 1993 |
Electrophysiological actions of delta opioids in CA1 of the rat hippocampal slice are mediated by one delta receptor subtype.
Topics: Analgesics; Animals; Electric Stimulation; Electrophysiology; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Evoked Potentials; Hippocampus; In Vitro Techniques; Indoles; Ligands; Male; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Pyramidal Tracts; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu | 1993 |
The kappa opioid agonist U-50,488H antagonizes respiratory effects of mu opioid receptor agonists in conscious rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Morphine; Naltrexone; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Respiration | 1993 |
Cocaine-like discriminative stimulus properties of the delta-selective opioid receptor agonist, [D-Pen2,L-Pen5]enkephalin, in the rat.
Topics: Animals; Cocaine; Discrimination Learning; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Generalization, Stimulus; Indoles; Morphinans; Naltrexone; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu | 1993 |
7-Benzylidenenaltrexone (BNTX): a selective delta 1 opioid receptor antagonist in the mouse spinal cord.
Topics: Analgesics; Animals; Benzylidene Compounds; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Naltrexone; Narcotic Antagonists; Oligopeptides; Receptors, Opioid, delta; Spinal Cord | 1993 |
Receptor mechanisms of opioid tolerance in SH-SY5Y human neural cells.
Topics: Adenylyl Cyclase Inhibitors; Amino Acid Sequence; Cyclic AMP; Down-Regulation; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; GTP Phosphohydrolases; Humans; Levorphanol; Molecular Sequence Data; Naltrexone; Narcotics; Neuroblastoma; Neurons; Receptors, Opioid; Signal Transduction; Tumor Cells, Cultured | 1993 |
Differential modulation of mu-opioid receptor-mediated antitussive activity by delta-opioid receptor agonists in mice.
Topics: Animals; Antitussive Agents; Cough; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Oligopeptides; Receptors, Opioid, delta; Receptors, Opioid, mu | 1993 |
Spinal delta 2 but not delta 1 opioid receptors are involved in intracerebroventricular beta-endorphin-induced antinociception in the mouse.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzylidene Compounds; beta-Endorphin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Nociceptors; Pain Measurement; Pyrrolidines; Receptors, Opioid, delta; Spinal Cord | 1993 |
Chronic exposure to morphine and naltrexone induces changes in catecholaminergic neurotransmission in rat brain without altering mu-opioid receptor sensitivity.
Topics: Adenylyl Cyclases; Animals; Binding Sites; Brain; Catecholamines; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Morphine; Naltrexone; Norepinephrine; Radioligand Assay; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Opioid, mu | 1993 |
Opioid control of the release of calcitonin gene-related peptide-like material from the rat spinal cord in vivo.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Calcitonin Gene-Related Peptide; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Spinal; Iodine Radioisotopes; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pyrrolidines; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1993 |
Dose-dependent antagonism of spinal opioid receptor agonists by naloxone and naltrindole: additional evidence for delta-opioid receptor subtypes in the rat.
Topics: Analgesics; Animals; Binding, Competitive; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; In Vitro Techniques; Injections, Spinal; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord | 1993 |
Selective opioid receptor agonists modulate mechanical allodynia in an animal model of neuropathic pain.
Topics: Analgesics; Animals; Benzeneacetamides; Benzomorphans; Disease Models, Animal; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain; Pain Measurement; Pain Threshold; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vocalization, Animal | 1993 |
Evidence for delta opioid receptor subtypes in rat spinal cord: studies with intrathecal naltriben, cyclic[D-Pen2, D-Pen5] enkephalin and [D-Ala2, Glu4]deltorphin.
Topics: Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Spinal; Male; Naltrexone; Narcotic Antagonists; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Reflex; Spinal Cord | 1993 |
DAMGO stimulates the hypothalamo-pituitary-adrenal axis through a mu-2 opioid receptor.
Topics: Analgesics; Animals; Corticosterone; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hypothalamo-Hypophyseal System; Male; Naloxone; Naltrexone; Pituitary-Adrenal System; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 1993 |
Selective and interactive down-regulation of mu- and delta-opioid receptors in human neuroblastoma SK-N-SH cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Down-Regulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Humans; Morphine; Naltrexone; Neuroblastoma; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, mu; Tumor Cells, Cultured | 1993 |
Altered transition between agonist- and antagonist-favoring states of mu-opioid receptor in brain membranes with modified microviscosity.
Topics: Animals; Brain; Cholesterol Esters; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Male; Membrane Fluidity; Membranes; Naltrexone; Oleic Acid; Oleic Acids; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Sodium Chloride; Sufentanil; Viscosity | 1993 |
Kinetic parameters of antagonism by the delta opioid receptor selective peptide antagonist Boc-Tyr-Pro-Gly-Phe-Leu-Thr against selective and non-selective agonists in the mouse vas deferens.
Topics: Analgesics; Animals; Anticonvulsants; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; In Vitro Techniques; Kinetics; Male; Mice; Mice, Inbred Strains; Morphine Derivatives; Naltrexone; Oligopeptides; Pyrroles; Receptors, Opioid, delta; Thiophenes; Vas Deferens | 1993 |
Opioid antagonists and antisera to endogenous opioids increase the nociceptive response to formalin: demonstration of an opioid kappa and delta inhibitory tone.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Formaldehyde; Immune Sera; Male; Naloxone; Naltrexone; Narcotic Antagonists; Opioid Peptides; Pain; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa | 1996 |
Effects of cold acclimation and central opioid processes on thermoregulation in rats.
Topics: Acclimatization; Analgesics; Animals; Body Temperature; Body Temperature Regulation; Cold Temperature; Conditioning, Operant; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Grooming; Injections, Intraventricular; Male; Motor Activity; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Salivary Glands; Telemetry | 1996 |
Intrastriatal injection of opioid receptor agonists inhibits apomorphine-induced behavior in 6-hydroxydopamine-treated mice.
Topics: Animals; Apomorphine; Behavior, Animal; Corpus Striatum; Dopamine; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Naltrexone; Oxidopamine; Peptide Fragments; Receptors, Opioid | 1995 |
Chronic opioid antagonist administration upregulates mu opioid receptor binding without altering mu opioid receptor mRNA levels.
Topics: Animals; Brain; Cell Membrane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Gene Expression; Kinetics; Male; Naltrexone; Narcotic Antagonists; Organ Specificity; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Reference Values; RNA, Messenger; Up-Regulation | 1995 |
Effects of beta-FNA on sympathoadrenal, cardiovascular, and analgesic responses to DAMPGO at rest and during stress.
Topics: Adrenal Glands; Analgesics; Animals; Blood Pressure; Catecholamines; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Heart Rate; Hemodynamics; Male; Naltrexone; Narcotic Antagonists; Organ Size; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Stress, Psychological; Sympathetic Nervous System | 1996 |
Effect of the highly selective and nonpeptide delta opioid receptor agonist TAN-67 on the morphine-induced place preference in mice.
Topics: Analgesics; Animals; Benzylidene Compounds; Dopamine; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Limbic System; Male; Mice; Morphine; Naltrexone; Quinolines; Receptors, Opioid, delta; Reward | 1996 |
Induction of Fos-like immunoreactivity by opioids in guinea-pig brain.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Opioid; Animals; Brain Chemistry; Diencephalon; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Guinea Pigs; Immunohistochemistry; Injections, Intraventricular; Male; Mesencephalon; Morphine; Naltrexone; Narcotic Antagonists; Neurons; Proto-Oncogene Proteins c-fos; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Telencephalon | 1996 |
Agonist-induced functional desensitization of the mu-opioid receptor is mediated by loss of membrane receptors rather than uncoupling from G protein.
Topics: Analgesics; Animals; Binding Sites; Cell Line; Cell Membrane; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Down-Regulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; GTP-Binding Proteins; Kidney; Kinetics; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu; Sensitivity and Specificity; Stimulation, Chemical; Transfection | 1996 |
Opioid receptor-mediated control of acetylcholine release in human neocortex tissue.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetylcholine; Adolescent; Adult; Aged; Analgesics; Analysis of Variance; Baclofen; Cerebral Cortex; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; GABA Agonists; Humans; Male; Middle Aged; Muscimol; Naloxone; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid, delta; Tetrodotoxin | 1996 |
Opioid receptor agonists activate pertussis toxin-sensitive G proteins and inhibit adenylyl cyclase in canine cardiac sarcolemma.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Analgesics; Analysis of Variance; Animals; Diprenorphine; Dogs; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; GTP Phosphohydrolases; GTP-Binding Proteins; Myocardium; Naltrexone; Narcotic Antagonists; Pertussis Toxin; Sarcolemma; Virulence Factors, Bordetella | 1996 |
Role of opioid receptors (mu, delta 1, delta 2) in modulating responses of nociceptive neurons in the superficial and deeper dorsal horn of the medulla (trigeminal nucleus caudalis) in the rat.
Topics: Animals; Benzylidene Compounds; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Evoked Potentials; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nerve Fibers; Neurons; Nociceptors; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Trigeminal Caudal Nucleus | 1996 |
Gastric effects of mu-, delta- and kappa-opioid receptor agonists on brainstem unitary responses in the neonatal rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Animals, Newborn; Brain Stem; Drug Interactions; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Solitary Nucleus; Stomach | 1996 |
Regulation of mu-opioid receptor in neural cells by extracellular sodium.
Topics: Adenylyl Cyclase Inhibitors; Amiloride; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Extracellular Space; Humans; Intracellular Membranes; Monensin; Naltrexone; Neurons; Osmolar Concentration; Ouabain; Receptors, Opioid, mu; Sodium; Tumor Cells, Cultured | 1997 |
(E)- and (Z)-7-arylidenenaltrexones: synthesis and opioid receptor radioligand displacement assays.
Topics: Animals; Benzeneacetamides; Benzomorphans; Benzylidene Compounds; Binding, Competitive; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Magnetic Resonance Spectroscopy; Mass Spectrometry; Models, Molecular; Molecular Conformation; Molecular Structure; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid, delta; Spectroscopy, Fourier Transform Infrared | 1997 |
Acute and chronic effects of opioids on delta and mu receptor activation of G proteins in NG108-15 and SK-N-SH cell membranes.
Topics: Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Glioma; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Hybrid Cells; Membrane Proteins; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Neuroblastoma; Protein Binding; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Signal Transduction; Sulfur Radioisotopes; Time Factors | 1997 |
Chronic morphine and naltrexone fail to modify mu-opioid receptor mRNA levels in the rat brain.
Topics: Animals; Brain; Corpus Striatum; DNA Primers; Drug Administration Schedule; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Morphine; Naltrexone; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; RNA, Messenger; Substance Withdrawal Syndrome | 1997 |
Modulation of neurotransmitter release by opioid mu- and kappa-receptors from adrenergic terminals in the myenteric plexus of the guinea-pig colon: effect of alpha 2-autoreceptor blockade.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics; Animals; Colon; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Myenteric Plexus; Naloxone; Naltrexone; Narcotic Antagonists; Neurotransmitter Agents; Norepinephrine; Pyrrolidines; Receptors, Adrenergic, alpha-2; Receptors, Opioid, kappa; Receptors, Opioid, mu; Yohimbine | 1997 |
Inhibition of swine microglial cell phagocytosis of Cryptococcus neoformans by femtomolar concentrations of morphine.
Topics: Animals; Cryptococcus neoformans; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; GTP-Binding Proteins; Microglia; Morphine; Naltrexone; Narcotics; Phagocytosis; Swine | 1997 |
Opioids in the nucleus of the solitary tract are involved in feeding in the rat.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Feeding Behavior; Male; Microinjections; Naltrexone; Rats; Rats, Sprague-Dawley; Solitary Nucleus | 1997 |
[Cardioprotective effects of stimulation of peripheral mu-opiate receptors, and the role of opiatergic mechanisms in the pathogenesis of stress-induced heart damage].
Topics: Animals; Cardiomyopathies; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Immobilization; Male; Naltrexone; Narcotic Antagonists; Oligopeptides; Rats; Rats, Wistar; Receptors, Opioid, mu; Stress, Physiological | 1997 |
Antisense mapping of the MOR-1 opioid receptor clone: modulation of hyperphagia induced by DAMGO.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hyperphagia; Male; Naltrexone; Oligonucleotides, Antisense; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 1997 |
Effects of intracerebroventricular administration of beta-funaltrexamine on DAMGO-stimulated [35S]GTP-gamma-S binding in rat brain sections.
Topics: Animals; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Injections, Intraventricular; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred F344; Receptors, Opioid, mu; Sulfur Radioisotopes | 1997 |
Anatomical distribution of mu, delta, and kappa opioid- and nociceptin/orphanin FQ-stimulated [35S]guanylyl-5'-O-(gamma-thio)-triphosphate binding in guinea pig brain.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Non-Narcotic; Animals; Autoradiography; Brain Chemistry; Cerebellum; Diencephalon; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Male; Medulla Oblongata; Mesencephalon; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptin; Opioid Peptides; Pons; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sulfur Radioisotopes; Telencephalon | 1997 |
Opioid receptor-mediated inhibition of omega-conotoxin GVIA-sensitive calcium channel currents in rat intracardiac neurons.
Topics: Acetylcholine; Animals; Animals, Newborn; Anti-Arrhythmia Agents; Benzomorphans; Calcium; Calcium Channels; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Heart Conduction System; Ion Channel Gating; Ion Transport; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; omega-Conotoxin GVIA; Parasympathetic Nervous System; Patch-Clamp Techniques; Peptides; Pertussis Toxin; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Virulence Factors, Bordetella | 1998 |
Effects of the opioid antagonist naltrexone on feeding induced by DAMGO in the central nucleus of the amygdala and in the paraventricular nucleus in the rat.
Topics: Amygdala; Animals; Eating; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections; Male; Naltrexone; Narcotic Antagonists; Paraventricular Hypothalamic Nucleus; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 1998 |
Ischemic preconditioning in the intact rat heart is mediated by delta1- but not mu- or kappa-opioid receptors.
Topics: Animals; Benzylidene Compounds; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hemodynamics; Ischemic Preconditioning, Myocardial; Male; Myocardial Infarction; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1998 |
Estrogen-induced alteration of mu-opioid receptor immunoreactivity in the medial preoptic nucleus and medial amygdala.
Topics: Amygdala; Analgesics, Opioid; Animals; Antibody Specificity; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Estrogens; Female; GTP-Binding Proteins; Naltrexone; Narcotic Antagonists; Opioid Peptides; Ovariectomy; Preoptic Area; Rats; Rats, Inbred Strains; Receptors, Opioid, mu; Tritium | 1998 |
Differential modulation of mu- and delta-opioid antinociception by neuropeptide FF receptors in young mice.
Topics: Age Factors; Analgesics, Opioid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Mice; Mice, Inbred Strains; Morphine; Naltrexone; Narcotic Antagonists; Neuropeptides; Nociceptors; Oligopeptides; Receptors, Neuropeptide; Receptors, Opioid, delta; Receptors, Opioid, mu | 1997 |
Differentiation of kappa opioid agonist-induced antinociception by naltrexone apparent pA2 analysis in rhesus monkeys.
Topics: Analgesics, Opioid; Animals; Cinnamates; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Macaca mulatta; Male; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Receptors, Opioid, kappa | 1998 |
Intake of high-fat food is selectively enhanced by mu opioid receptor stimulation within the nucleus accumbens.
Topics: Animals; Dietary Carbohydrates; Dietary Fats; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Food Deprivation; Male; Naltrexone; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 1998 |
The effects of aging on mu and delta opioid receptors in the spinal cord of Fischer-344 rats.
Topics: Aging; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Naltrexone; Narcotic Antagonists; Radioligand Assay; Rats; Rats, Inbred F344; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord | 1998 |
Role of central opioid receptor subtypes in morphine-induced alterations in peripheral lymphocyte activity.
Topics: Analgesics, Opioid; Animals; Brain; Cell Division; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intraventricular; Lymphocytes; Male; Morphine; Naltrexone; Narcotic Antagonists; Nociceptors; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1998 |
Quantitative immunolocalization of mu opioid receptors: regulation by naltrexone.
Topics: Analgesics, Opioid; Animals; Autoradiography; Brain Chemistry; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Naltrexone; Narcotic Antagonists; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Tritium; Up-Regulation | 1998 |
The role of peripheral mu opioid receptors in the modulation of capsaicin-induced thermal nociception in rhesus monkeys.
Topics: Animals; Azocines; Capsaicin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Hot Temperature; Macaca mulatta; Male; Naltrexone; Pain; Receptors, Opioid, mu | 1998 |
Affinity profiles of novel delta-receptor selective benzofuran derivatives of non-peptide opioids.
Topics: Animals; Benzeneacetamides; Benzofurans; Binding, Competitive; Brain; Cell Membrane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Naloxone; Naltrexone; Oligopeptides; Oxycodone; Oxymorphone; Pyrrolidines; Radioligand Assay; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Tritium | 1998 |
Role of central mu-opioid receptors in the modulation of nitric oxide production by splenocytes.
Topics: Analgesics; Analgesics, Opioid; Animals; Bacterial Toxins; Benzeneacetamides; Cell Division; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Enterotoxins; Enzyme Inhibitors; Injections, Intraventricular; Lymphocytes; Male; Naltrexone; Narcotic Antagonists; Neuroimmunomodulation; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Pyrrolidines; Quaternary Ammonium Compounds; Rats; Rats, Inbred Lew; Receptors, Opioid, mu; Spleen; Superantigens | 1998 |
Association between the amygdala and nucleus of the solitary tract in mu-opioid induced feeding in the rat.
Topics: Amygdala; Animals; Eating; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Solitary Nucleus | 1998 |
Relationship between inhibitory effect of endogenous opioid via mu-receptors and muscarinic autoinhibition in acetylcholine release from myenteric plexus of guinea pig ileum.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetylcholine; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Atropine; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphinans; Muscarine; Muscarinic Agonists; Muscarinic Antagonists; Muscle, Smooth; Myenteric Plexus; Naltrexone; Narcotic Antagonists; Opioid Peptides; Receptors, Muscarinic; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1998 |
Apparent thermodynamic parameters of ligand binding to the cloned rat mu-opioid receptor.
Topics: Analgesics; Animals; Binding, Competitive; CHO Cells; Cricetinae; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Fentanyl; Ligands; Methadone; Morphine; Naltrexone; Narcotic Antagonists; Pentazocine; Peptide Fragments; Peptides; Radioligand Assay; Rats; Receptors, Opioid, mu; Somatostatin; Sufentanil; Thermodynamics; Time Factors | 1998 |
Inhibition of the neuronal nicotinic receptor-mediated current by kappa opioid receptor agonists in PC12 cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Dynorphins; Electric Conductivity; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Naltrexone; Narcotic Antagonists; Neurons; Nicotinic Antagonists; PC12 Cells; Rats; Receptors, Nicotinic; Receptors, Opioid, kappa | 1998 |
Effects of beta-funaltrexamine on dose-effect curves for heroin self-administration in rats: comparison with alteration of [3H]DAMGO binding to rat brain sections.
Topics: Analgesics, Opioid; Animals; Brain; Caudate Nucleus; Cocaine; Culture Techniques; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Heroin; Heroin Dependence; Motivation; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Radioligand Assay; Rats; Receptors, Opioid, mu; Self Administration | 1998 |
The effect of pentylenetetrazol kindling on synaptic mechanisms of interacting glutamatergic and opioid system in the hippocampus of rats.
Topics: Animals; Convulsants; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hippocampus; In Vitro Techniques; Kindling, Neurologic; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pentylenetetrazole; Rats; Rats, Wistar; Receptors, Glutamate; Receptors, Opioid; Seizures; Synapses | 1998 |
5-HT4 receptor agonists and delta-opioid receptor antagonists act synergistically to stimulate colonic propulsion.
Topics: Animals; Benzeneacetamides; Colon; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Guinea Pigs; In Vitro Techniques; Male; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Peptide Fragments; Peristalsis; Pyrrolidines; Receptors, Opioid, delta; Receptors, Serotonin; Receptors, Serotonin, 5-HT4; Serotonin Receptor Agonists; Somatostatin | 1998 |
Synthesis and biological activity of 3-substituted 3-desoxynaltrindole derivatives.
Topics: Animals; Benzeneacetamides; Binding, Competitive; Brain; Cell Membrane; Drug Design; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Molecular Structure; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rats; Receptors, Opioid, delta; Structure-Activity Relationship | 1998 |
Opioid peptide pharmacology and immunocytochemistry in an animal model of self-sustaining status epilepticus.
Topics: Action Potentials; Analgesics; Analgesics, Opioid; Animals; Disease Models, Animal; Dynorphins; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Immunohistochemistry; Male; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Opioid Peptides; Peptide Fragments; Perforant Pathway; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Status Epilepticus | 1999 |
Immunomodulatory action of class mu-, delta- and kappa-opioid receptor agonists in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Immunity; Lymphocyte Activation; Male; Mice; Mice, Inbred C57BL; Mitogens; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; T-Lymphocytes | 1998 |
Opioidergic modulation of voltage-activated K+ currents in magnocellular neurons of the supraoptic nucleus in rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Ion Channel Gating; Membrane Potentials; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Patch-Clamp Techniques; Potassium Channels; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Supraoptic Nucleus | 1999 |
Growth inhibitory effects of a mu opioid on cultured cholinergic neurons from fetal rat ventral forebrain, brainstem, and spinal cord.
Topics: Analgesics, Opioid; Animals; Brain Stem; Cell Division; Cells, Cultured; Choline; Choline O-Acetyltransferase; Cholinergic Fibers; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Naltrexone; Narcotic Antagonists; Neurons; Prosencephalon; Rats; Rats, Wistar; Receptors, Opioid, mu; Respiration; Spinal Cord; Tritium | 1999 |
Gastric effects of methylnaltrexone on mu, kappa, and delta opioid agonists induced brainstem unitary responses.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Animals, Newborn; Brain Stem; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Morphine; Naltrexone; Narcotic Antagonists; Neurons; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Solitary Nucleus; Stomach; Vagus Nerve | 1999 |
Differential involvement of mu-opioid receptor subtypes in endomorphin-1- and -2-induced antinociception.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intraventricular; Injections, Spinal; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Oligopeptides; Pain; Receptors, Opioid, mu; Time Factors | 1999 |
Membrane microviscosity modulates mu-opioid receptor conformational transitions and agonist efficacy.
Topics: Animals; Cell Line; Cell Membrane; Cholesterol Esters; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Glioma; Guanosine 5'-O-(3-Thiotriphosphate); Membrane Fluidity; Nalbuphine; Naltrexone; Narcotic Antagonists; Narcotics; Neuroblastoma; Protein Conformation; Rats; Receptors, Opioid, mu; Sodium Chloride; Sufentanil; Tumor Cells, Cultured; Viscosity | 1999 |
Effects of diethylstilbestrol on mouse hippocampal evoked potentials in vitro.
Topics: Animals; Binding, Competitive; Dactinomycin; Diethylstilbestrol; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Estrogens; Excitatory Postsynaptic Potentials; Hippocampus; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Nerve Tissue Proteins; Pyramidal Cells; Receptors, Opioid; Receptors, Opioid, mu | 1999 |
Synthesis, opioid receptor binding, and biological activities of naltrexone-derived pyrido- and pyrimidomorphinans.
Topics: Analgesics; Animals; Binding, Competitive; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Ileum; Male; Mice; Mice, Inbred Strains; Morphinans; Morphine; Muscle Contraction; Naltrexone; Protein Binding; Rats; Receptors, Opioid; Vas Deferens | 1999 |
Opioid peptide receptor studies. 10. Nor-BNI differentially inhibits kappa receptor agonist-induced G-protein activation in the guinea pig caudate: further evidence of kappa receptor heterogeneity.
Topics: Animals; Benzeneacetamides; Benzodiazepines; Brain; Caudate Nucleus; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; In Vitro Techniques; Inhibitory Concentration 50; Naltrexone; Oligopeptides; Peptide Fragments; Peptides; Pyrrolidines; Rats; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin | 1999 |
Highly delta selective antagonists in the RVM attenuate the antinociceptive effect of PAG DAMGO.
Topics: Analgesics; Analgesics, Opioid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Male; Medulla Oblongata; Naltrexone; Narcotic Antagonists; Neural Pathways; Oligopeptides; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Tetrahydroisoquinolines | 1999 |
Identification of the G-protein-coupled ORL1 receptor in the mouse spinal cord by [35S]-GTPgammaS binding and immunohistochemistry.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Atropine; Autoradiography; Baclofen; Binding, Competitive; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Haloperidol; Immunohistochemistry; In Vitro Techniques; Male; Membranes; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Nociceptin; Nociceptin Receptor; Opioid Peptides; Peptide Fragments; Propranolol; Receptors, Opioid; Somatostatin; Spinal Cord; Sulfur Radioisotopes; Yohimbine | 1999 |
Enhanced delta-opioid receptor-mediated antinociception in mu-opioid receptor-deficient mice.
Topics: Analgesia; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Hyperalgesia; Mice; Mice, Inbred C57BL; Mice, Knockout; Naltrexone; Receptors, Opioid, delta; Receptors, Opioid, mu | 2000 |
Changes in analgesia-producing mechanism of repeated cold stress loading in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Anti-Anxiety Agents; Anxiety; Cold Temperature; Diazepam; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Pain Threshold; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stress, Physiological | 2000 |
8-Aminocyclazocine analogues: synthesis and structure-activity relationships.
Topics: Analgesics; Animals; Benzeneacetamides; Binding, Competitive; Brain; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Guinea Pigs; Molecular Structure; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Stereoisomerism; Structure-Activity Relationship | 2000 |
Inhibitory effect of intracerebroventricularly-administered [D-Arg(2), beta-Ala(4)]-dermorphin (1-4) on gastrointestinal transit.
Topics: Analgesics; Animals; Charcoal; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Female; Gastrointestinal Transit; Injections, Intraventricular; Mice; Mice, Inbred Strains; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides | 2000 |
Selective antagonism by naloxonazine of antinociception by Tyr-D-Arg-Phe-beta-Ala, a novel dermorphin analogue with high affinity at mu-opioid receptors.
Topics: Analgesics; Analgesics, Opioid; Animals; Drug Antagonism; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Injections, Intraventricular; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Opioid Peptides; Pain Measurement; Receptors, Opioid, mu; Time Factors | 2000 |
Antinociception produced by mu opioid receptor activation in the amygdala is partly dependent on activation of mu opioid and neurotensin receptors in the ventral periaqueductal gray.
Topics: Amygdala; Analgesics, Opioid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Male; Naltrexone; Narcotic Antagonists; Neural Pathways; Neurons; Neurotensin; Nociceptors; Pain; Peptides; Periaqueductal Gray; Rats; Rats, Long-Evans; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotensin; Receptors, Opioid, delta; Receptors, Opioid, mu; Time Factors; Valine | 2000 |
5'-Guanidinonaltrindole, a highly selective and potent kappa-opioid receptor antagonist.
Topics: Animals; CHO Cells; Cricetinae; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Guanidines; Guinea Pigs; Humans; In Vitro Techniques; Ligands; Male; Membranes; Mice; Mice, Inbred ICR; Morphinans; Muscle, Smooth; Naltrexone; Receptors, Opioid, kappa | 2000 |
Role of agonist-dependent receptor internalization in the regulation of mu opioid receptors.
Topics: Acetylcholine; Animals; Electric Stimulation; Endocytosis; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enteric Nervous System; Guinea Pigs; Ileum; Morphine; Naltrexone; Narcotic Antagonists; Neurons; Opioid Peptides; Organ Culture Techniques; Receptors, Opioid, mu | 2000 |
Altered opioid-mediated control of the spinal release of dynorphin and met-enkephalin in polyarthritic rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia; Animals; Arthritis; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Iodine Radioisotopes; Ligands; Male; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 2000 |
Receptor selectivity of Met-enkephalin-Arg6-Phe7, an endogenous opioid peptide, in cerebral cortex of human and rat.
Topics: Adult; Animals; Benzeneacetamides; Benzomorphans; Binding Sites; Cerebral Cortex; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Ethylketocyclazocine; Female; Humans; Male; Naloxone; Naltrexone; Norepinephrine; Oligopeptides; Peptide Fragments; Peptides; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Somatostatin | 2000 |
beta-Funaltrexamine inactivates ORL1 receptors in BE(2)-C human neuroblastoma cells.
Topics: Brain Neoplasms; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Humans; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Neuroblastoma; Nociceptin; Nociceptin Receptor; Opioid Peptides; Receptors, Opioid; Receptors, Opioid, mu; Tumor Cells, Cultured | 2000 |
Antagonism of delta(2)-opioid receptors by naltrindole-5'-isothiocyanate attenuates heroin self-administration but not antinociception in rats.
Topics: Analgesics, Opioid; Animals; Cocaine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Heroin; Injections, Intraventricular; Isothiocyanates; Male; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain Measurement; Rats; Rats, Inbred F344; Receptors, Opioid, delta; Reinforcement, Psychology; Self Administration | 2000 |
Selectivity of mu-opioid receptor determined by interfacial residues near third extracellular loop.
Topics: Amino Acid Substitution; Animals; Benzamides; Benzomorphans; Binding Sites; Binding, Competitive; COS Cells; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Fentanyl; Guanosine 5'-O-(3-Thiotriphosphate); Ligands; Morphine; Mutation; Naloxone; Naltrexone; Narcotic Antagonists; Peptides; Piperazines; Protein Conformation; Radioligand Assay; Rats; Receptors, Opioid, mu; Signal Transduction; Sulfur Radioisotopes | 2000 |
Involvement of central mu- but not delta- or kappa-opioid receptors in immunomodulation.
Topics: Animals; Brain; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Immune System; Male; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Rats; Rats, Inbred Lew; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2000 |
Inverse agonism by Dmt-Tic analogues and HS 378, a naltrindole analogue.
Topics: Benzamides; Benzeneacetamides; Binding, Competitive; Cell Line; Cell Membrane; Dipeptides; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Isoquinolines; Naltrexone; Narcotic Antagonists; Piperazines; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sulfur Radioisotopes; Tetrahydroisoquinolines | 2000 |
Activation of mu- and delta-opioid receptors causes presynaptic inhibition of glutamatergic excitation in neocortical neurons.
Topics: Action Potentials; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Excitatory Amino Acid Antagonists; Female; GABA-A Receptor Antagonists; GABA-B Receptor Antagonists; Glutamic Acid; Iontophoresis; Male; Naltrexone; Narcotic Antagonists; Neocortex; Neurons; Rats; Rats, Wistar; Receptors, AMPA; Receptors, GABA-A; Receptors, GABA-B; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, delta; Receptors, Opioid, mu; Synapses; Synaptic Transmission | 2000 |
Endomorphin-1 induces antinociception without immunomodulatory effects in the rat.
Topics: Analgesics, Opioid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Immune System; Injections, Intraventricular; Interferon-gamma; Lymphocyte Activation; Male; Morphine; Naltrexone; Oligopeptides; Rats; Rats, Inbred Lew | 2000 |
Differential antagonism of endomorphin-1 and endomorphin-2 spinal antinociception by naloxonazine and 3-methoxynaltrexone.
Topics: Analgesics, Opioid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Heroin; Injections, Spinal; Male; Mice; Naloxone; Naltrexone; Oligopeptides; Pain Measurement; Receptors, Opioid, mu | 2000 |
Selective kappa-opioid antagonists related to naltrindole. Effect of side-chain spacer in the 5'-amidinoalkyl series.
Topics: Amidines; Animals; Benzeneacetamides; Binding, Competitive; Brain; Cell Membrane; Drug Design; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Guinea Pigs; Indicators and Reagents; Kinetics; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid, kappa; Structure-Activity Relationship | 2000 |
Morphine-6 beta-glucuronide has a higher efficacy than morphine as a mu-opioid receptor agonist in the rat locus coeruleus.
Topics: Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Locus Coeruleus; Male; Membrane Potentials; Morphine; Morphine Derivatives; Naltrexone; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 2000 |
delta-, but not mu- and kappa-, opioid receptor activation protects neocortical neurons from glutamate-induced excitotoxic injury.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Cells, Cultured; Cytoprotection; Embryo, Mammalian; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Excitatory Amino Acid Agonists; Female; Glutamic Acid; L-Lactate Dehydrogenase; Naltrexone; Narcotic Antagonists; Neocortex; Neurons; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2000 |
Morphine inhibits human microglial cell production of, and migration towards, RANTES.
Topics: Brain; Calcium; Cells, Cultured; Chemokine CCL5; Chemotaxis; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Fetus; Humans; Interleukin-1; Lipopolysaccharides; Microglia; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Recombinant Proteins | 2000 |
Pharmacological effects of naltriben as a ligand for opioid mu and kappa receptors in rat cerebral cortex.
Topics: Animals; Cerebral Cortex; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Ligands; Male; Naloxone; Naltrexone; Narcotic Antagonists; Norepinephrine; Peptide Fragments; Peptides; Potassium; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin; Tritium | 2001 |
Activity of mu- and delta-opioid agonists in vas deferens from mice deficient in MOR gene.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Female; Genotype; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Mutant Strains; Morphine; Muscle Contraction; Naltrexone; Narcotic Antagonists; Oligopeptides; Receptors, Opioid, delta; Receptors, Opioid, mu; Vas Deferens | 2001 |
Contribution of endogenous enkephalins to the enhanced analgesic effects of supraspinal mu opioid receptor agonists after inflammatory injury.
Topics: Animals; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Inflammation; Male; Microinjections; Naltrexone; Pain; Peptide Fragments; Peptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Somatostatin | 2001 |
Opioids suppress basal and nicotine-induced catecholamine secretion via a stabilizing effect on actin filaments.
Topics: Actins; Animals; Benzeneacetamides; Cytochalasin B; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Humans; Naltrexone; Narcotics; Nicotine; Norepinephrine; PC12 Cells; Pyrrolidines; Rats | 2001 |
Respiratory function in adult mice lacking the mu-opioid receptor: role of delta-receptors.
Topics: Analgesics, Opioid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Female; Male; Medulla Oblongata; Mice; Mice, Knockout; Naltrexone; Narcotic Antagonists; Neurons; Oligopeptides; Organ Culture Techniques; Receptors, Opioid, delta; Receptors, Opioid, mu; Respiratory Center; Respiratory Physiological Phenomena | 2001 |
Stimulation of guanosine-5'-o-(3-[35S]thio)triphosphate binding in digitonin-permeabilized C6 rat glioma cells: evidence for an organized association of mu-opioid receptors and G protein.
Topics: Analgesics, Opioid; Animals; Digitonin; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Glioma; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Indicators and Reagents; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Receptors, Opioid, mu; Tumor Cells, Cultured | 2001 |
Blockade of opioid receptors in rostral ventral medulla prevents antihyperalgesia produced by transcutaneous electrical nerve stimulation (TENS).
Topics: Analgesics, Opioid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Hot Temperature; Hyperalgesia; Male; Medulla Oblongata; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Transcutaneous Electric Nerve Stimulation | 2001 |
Chronic exposure to mu-opioid agonists produces constitutive activation of mu-opioid receptors in direct proportion to the efficacy of the agonist used for pretreatment.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Analgesics, Opioid; Animals; Binding Sites; Cells, Cultured; Cyclic AMP; Down-Regulation; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Receptors, Opioid, mu; Sulfur Radioisotopes; Transfection; Virulence Factors, Bordetella | 2001 |
gamma-Aminobutyric acid receptor subtype antagonists differentially alter opioid-induced feeding in the shell region of the nucleus accumbens in rats.
Topics: Animals; Baclofen; Bicuculline; Eating; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; GABA Agonists; GABA Antagonists; GABA-A Receptor Antagonists; GABA-B Receptor Antagonists; gamma-Aminobutyric Acid; Male; Naltrexone; Narcotic Antagonists; Narcotics; Neurons; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, GABA; Receptors, GABA-A; Receptors, GABA-B; Receptors, Opioid | 2001 |
Progesterone blockade of estrogen activation of mu-opioid receptors regulates reproductive behavior.
Topics: Analgesics, Opioid; Animals; Cell Count; Dose-Response Relationship, Drug; Drug Administration Schedule; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Estradiol; Estrogens; Female; Immunohistochemistry; Male; Naltrexone; Narcotic Antagonists; Oligopeptides; Ovariectomy; Posture; Preoptic Area; Progesterone; Rats; Rats, Long-Evans; Receptors, Opioid, mu; Sexual Behavior, Animal; Somatostatin | 2001 |
The kappa-opioid antagonist GNTI reduces U50,488-, DAMGO-, and deprivation-induced feeding, but not butorphanol- and neuropeptide Y-induced feeding in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Brain; Butorphanol; Drug Interactions; Eating; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Food Deprivation; Guanidines; Male; Morphinans; Naltrexone; Narcotic Antagonists; Narcotics; Neuropeptide Y; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa | 2001 |
Constitutively active mu-opioid receptors inhibit adenylyl cyclase activity in intact cells and activate G-proteins differently than the agonist [D-Ala2,N-MePhe4,Gly-ol5]enkephalin.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Cell Line; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; GTP-Binding Proteins; Naltrexone; Potassium Chloride; Protein Binding; Receptors, Opioid, mu; Virulence Factors, Bordetella | 2001 |
SoRI 9409, a non-peptide opioid mu receptor agonist/delta receptor antagonist, fails to stimulate [35S]-GTP-gamma-S binding at cloned opioid receptors.
Topics: Analgesics; Analgesics, Opioid; Animals; Benzamides; Benzeneacetamides; Binding, Competitive; CHO Cells; Cloning, Molecular; Cricetinae; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Iodine Radioisotopes; Morphine; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Piperazines; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sulfur Radioisotopes; Tritium | 2001 |
Differential antinociceptive effects induced by intrathecally administered endomorphin-1 and endomorphin-2 in the mouse.
Topics: Analgesics; Animals; Benzylidene Compounds; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Methionine; Immune Sera; Injections, Spinal; Injections, Subcutaneous; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain; Pain Measurement; Pain Threshold; Peptide Fragments; Time Factors | 2001 |
Excitatory amino acid receptor subtype agonists induce feeding in the nucleus accumbens shell in rats: opioid antagonist actions and interactions with mu-opioid agonists.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Excitatory Amino Acid Agonists; Feeding Behavior; Male; N-Methylaspartate; Naltrexone; Narcotic Antagonists; Neurons; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, mu; Synaptic Transmission | 2001 |
Analysis of opioid receptor subtype antagonist effects upon mu opioid agonist-induced feeding elicited from the ventral tegmental area of rats.
Topics: Animals; Appetite Regulation; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Feeding Behavior; Male; Naltrexone; Narcotic Antagonists; Narcotics; Neural Pathways; Neurons; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Synaptic Transmission; Ventral Tegmental Area | 2002 |
Predominance of delta-opioid-binding sites in the porcine enteric nervous system.
Topics: Animals; Benzeneacetamides; Binding Sites; Cell Membrane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enteric Nervous System; Female; In Vitro Techniques; Intestinal Mucosa; Intestines; Male; Myenteric Plexus; Naltrexone; Narcotic Antagonists; Neurons; Pyrrolidines; Radioligand Assay; Radiopharmaceuticals; Receptors, Opioid, delta; Saxitoxin; Swine | 2002 |
Potentiation of the excitatory action of NMDA in ventrolateral periaqueductal gray by the mu-opioid receptor agonist, DAMGO.
Topics: Action Potentials; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enzyme Inhibitors; Ethylmaleimide; Female; Male; N-Methylaspartate; Naltrexone; Narcotic Antagonists; Neural Inhibition; Neural Pathways; Neurons; Organ Culture Techniques; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, mu; Synaptic Transmission | 2002 |
Alterations in food intake elicited by GABA and opioid agonists and antagonists administered into the ventral tegmental area region of rats.
Topics: Administration, Oral; Analgesics, Opioid; Animals; Baclofen; Eating; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Food Preferences; GABA Agonists; GABA Antagonists; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; GABA-B Receptor Agonists; GABA-B Receptor Antagonists; Male; Microinjections; Muscimol; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, mu; Ventral Tegmental Area | 2002 |
Lack of the nociceptin receptor does not affect acute or chronic nociception in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Female; Male; Mice; Mice, Knockout; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptin; Nociceptin Receptor; Oligopeptides; Opioid Peptides; Pain; Receptors, Opioid; Time Factors; Vas Deferens | 2002 |
Quantitative stoichiometry of G-proteins activated by mu-opioid receptors in postmortem human brain.
Topics: Alkylation; Analgesics, Opioid; Baclofen; Binding, Competitive; Brain Chemistry; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enzyme Inhibitors; Ethylmaleimide; GABA Agonists; GTP-Binding Protein Regulators; GTP-Binding Proteins; Humans; In Vitro Techniques; Kinetics; Membranes; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu; Signal Transduction | 2002 |
Opioid receptor subtypes differentially modulate serotonin efflux in the rat central nervous system.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Central Nervous System; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Male; Microdialysis; Microinjections; Naltrexone; Nucleus Accumbens; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Serotonin | 2002 |
Antagonistic property of buprenorphine for putative epsilon-opioid receptor-mediated G-protein activation by beta-endorphin in pons/medulla of the mu-opioid receptor knockout mouse.
Topics: Animals; beta-Endorphin; Binding, Competitive; Buprenorphine; Cell Membrane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Female; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Male; Medulla Oblongata; Mice; Mice, Knockout; Naltrexone; Narcotic Antagonists; Narcotics; Neurons; Peptide Fragments; Pons; Radioligand Assay; Receptors, Opioid; Receptors, Opioid, mu; Rhombencephalon; Sulfur Radioisotopes; Synaptic Transmission | 2002 |
Potency differences for D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 as an antagonist of peptide and alkaloid micro-agonists in an antinociception assay.
Topics: Alkaloids; Analgesics, Opioid; Animals; Binding, Competitive; Buprenorphine; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Etorphine; Injections, Intraventricular; Injections, Subcutaneous; Male; Morphine; Naltrexone; Narcotic Antagonists; Opioid Peptides; Pain Measurement; Peptide Fragments; Peptides; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid, mu; Somatostatin | 2003 |
Activity of opioid ligands in cells expressing cloned mu opioid receptors.
Topics: Azocines; beta-Endorphin; Binding, Competitive; Butorphanol; Cell Line; Colforsin; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Etorphine; Fentanyl; Humans; Hydromorphone; Ligands; Morphine; Naltrexone; Phenazocine; Radioligand Assay; Receptors, Opioid, mu; Tritium | 2003 |
Blockade of mu-opioid receptor-mediated G-protein activation and antinociception by TRK-820 in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; GTP-Binding Proteins; In Vitro Techniques; Injections, Intraventricular; Medulla Oblongata; Mice; Morphinans; Naltrexone; Narcotic Antagonists; Pain Measurement; Pons; Radioligand Assay; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spiro Compounds | 2003 |
Opioid agonists have different efficacy profiles for G protein activation, rapid desensitization, and endocytosis of mu-opioid receptors.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Electric Conductivity; Endocytosis; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; GTP-Binding Proteins; Methadone; Mice; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Neuroblastoma; Pentazocine; Pituitary Neoplasms; Receptors, Opioid, mu; Transfection; Tumor Cells, Cultured | 2003 |
Identity of the putative delta1-opioid receptor as a delta-kappa heteromer in the mouse spinal cord.
Topics: Animals; Benzylidene Compounds; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Immune Sera; Mice; Naltrexone; Oligopeptides; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin; Spinal Cord | 2003 |
Buprenorphine blocks epsilon- and micro-opioid receptor-mediated antinociception in the mouse.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; beta-Endorphin; Buprenorphine; Disease Models, Animal; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Time Factors | 2003 |
Opioids and the apoptotic pathway in human cancer cells.
Topics: Annexin A5; Apoptosis; Cell Adhesion; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Etorphine; Growth Substances; Humans; In Situ Nick-End Labeling; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Necrosis; Neoplasms; Tumor Cells, Cultured | 2003 |
Effects of in vitro and in vivo opioids on the production of IL-12 and IL-10 by murine macrophages.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enzyme-Linked Immunosorbent Assay; Interleukin-10; Interleukin-12; Macrophages, Peritoneal; Male; Mice; Mice, Inbred BALB C; Morphine; Naltrexone; Pain | 2003 |
Effects of the opioid antagonist naltrexone on feeding induced by DAMGO in the ventral tegmental area and in the nucleus accumbens shell region in the rat.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Eating; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Male; Microinjections; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Ventral Tegmental Area | 2003 |
Vivitrex, an injectable, extended-release formulation of naltrexone, provides pharmacokinetic and pharmacodynamic evidence of efficacy for 1 month in rats.
Topics: Animals; Brain; Delayed-Action Preparations; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Injections, Intramuscular; Male; Naltrexone; Protein Binding; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid; Time Factors | 2003 |
Expression of EGFP-amino-tagged human mu opioid receptor in Drosophila Schneider 2 cells: a potential expression system for large-scale production of G-protein coupled receptors.
Topics: Animals; Binding, Competitive; Blotting, Western; Cell Line; Cloning, Molecular; Colforsin; Copper Sulfate; Cyclic AMP; Diprenorphine; DNA, Complementary; Drosophila; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Gene Expression; Genetic Vectors; Green Fluorescent Proteins; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Luminescent Proteins; Metallothionein; Microscopy, Confocal; Morphine; Naloxone; Naltrexone; Oligopeptides; Opioid Peptides; Pertussis Toxin; Polymerase Chain Reaction; Protein Binding; Receptors, G-Protein-Coupled; Receptors, Opioid, mu; Recombinant Fusion Proteins; Spectrometry, Fluorescence; Thermodynamics | 2003 |
Effects of endomorphin on substantia gelatinosa neurons in rat spinal cord slices.
Topics: Animals; Bicuculline; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Excitatory Postsynaptic Potentials; Female; Male; Membrane Potentials; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Oligopeptides; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Spinal Cord; Substantia Gelatinosa; Tetrodotoxin; Time Factors | 2003 |
Pharmacological characterization of a 7-benzylidenenaltrexone-preferring opioid receptor in porcine ileal submucosa.
Topics: Amphibian Proteins; Animals; Anions; Benzamides; Benzylidene Compounds; Biological Transport, Active; Carrier Proteins; Diprenorphine; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Female; Gastrointestinal Motility; Ileum; Intestinal Mucosa; Male; Naltrexone; Neurons, Afferent; Oligopeptides; Piperazines; Quinolines; Receptors, Opioid, delta; Receptors, Opioid, mu; Swine; Tritium | 2003 |
Evidence for a mu-opioid-opioid connection between the paraventricular nucleus and ventral tegmental area in the rat.
Topics: Analgesics, Opioid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Feeding Behavior; Injections, Intraventricular; Male; Naltrexone; Narcotic Antagonists; Paraventricular Hypothalamic Nucleus; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Ventral Tegmental Area | 2003 |
Kappa-opioid agonists directly inhibit midbrain dopaminergic neurons.
Topics: Analgesics; Animals; Benzeneacetamides; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; In Vitro Techniques; Male; Mesencephalon; Naltrexone; Narcotic Antagonists; Neural Inhibition; Neurons; Patch-Clamp Techniques; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Ventral Tegmental Area | 2003 |
Opioid partial agonist effects of 3-O-methylnaltrexone in rhesus monkeys.
Topics: Adenylyl Cyclases; Animals; Cocaine; Discrimination Learning; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Heroin; Heroin Dependence; Macaca mulatta; Male; Morphine; Morphine Derivatives; Naltrexone; Narcotics; Quaternary Ammonium Compounds; Receptors, Opioid, mu; Self Administration | 2004 |
Opioid-mediated modulation of calcium currents in striatal and pallidal neurons following reserpine treatment: focus on kappa response.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic Uptake Inhibitors; Alkaloids; Analgesics, Non-Narcotic; Analgesics, Opioid; Analysis of Variance; Animals; Benzophenanthridines; Calcium Channel Blockers; Calcium Channels; Cell Size; Cells, Cultured; Corpus Striatum; Dose-Response Relationship, Drug; Drug Interactions; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enzyme Inhibitors; Male; Membrane Potentials; Naltrexone; Narcotic Antagonists; Neural Inhibition; Neurons; omega-Conotoxin GVIA; Patch-Clamp Techniques; Phenanthridines; Rats; Rats, Wistar; Receptors, Opioid, kappa; Reserpine | 2004 |
Syntheses and receptor-binding studies of derivatives of the opioid antagonist naltrexone.
Topics: Animals; Biochemistry; Brain; Crystallography, X-Ray; Drug Evaluation, Preclinical; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Guinea Pigs; Ligands; Mice; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Stereoisomerism; Structure-Activity Relationship | 2004 |
Na+ modulation, inverse agonism, and anorectic potency of 4-phenylpiperidine opioid antagonists.
Topics: Animals; Appetite Depressants; Binding, Competitive; Cell Membrane; CHO Cells; Cricetinae; Cyclohexanes; Diprenorphine; Dose-Response Relationship, Drug; Eating; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Guanosine 5'-O-(3-Thiotriphosphate); Ligands; Naltrexone; Narcotic Antagonists; Piperidines; Radioligand Assay; Rats; Rats, Zucker; Receptors, Opioid; Receptors, Opioid, delta; Sodium | 2004 |
A bi-directional mu-opioid-opioid connection between the nucleus of the accumbens shell and the central nucleus of the amygdala in the rat.
Topics: Amygdala; Animals; Eating; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Feeding Behavior; Male; Naltrexone; Narcotic Antagonists; Neural Pathways; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 2004 |
A Tyr-W-MIF-1 analog containing D-Pro2 acts as a selective mu2-opioid receptor antagonist in the mouse.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Male; Mice; MSH Release-Inhibiting Hormone; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Receptors, Opioid, mu | 2005 |
Modulation of synaptic transmission in the rat nucleus of the solitary tract by endomorphin-1.
Topics: Analgesics, Opioid; Analysis of Variance; Anesthetics, Local; Animals; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Excitatory Postsynaptic Potentials; Glutamates; Green Fluorescent Proteins; Herpesvirus 1, Suid; In Vitro Techniques; Male; Membrane Potentials; Naltrexone; Narcotic Antagonists; Neural Inhibition; Neurons; Oligopeptides; Patch-Clamp Techniques; Peptide Fragments; Peptides; Photolysis; Rats; Rats, Sprague-Dawley; Solitary Nucleus; Somatostatin; Synaptic Transmission; Tetrodotoxin; Time Factors | 2005 |
Characterisation of opioid receptors involved in modulating circular and longitudinal muscle contraction in the rat ileum.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enteric Nervous System; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Muscle Contraction; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu | 2005 |
A heterodimer-selective agonist shows in vivo relevance of G protein-coupled receptor dimers.
Topics: Analgesics; Cell Line; Dimerization; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Guanidines; Humans; Kidney; Kinetics; Naltrexone; Receptors, G-Protein-Coupled; Receptors, Opioid; Transfection | 2005 |
Nalmefene induced elevation in serum prolactin in normal human volunteers: partial kappa opioid agonist activity?
Topics: Adolescent; Adult; Analgesics, Opioid; Animals; Benzeneacetamides; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Estradiol; Female; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Male; Naltrexone; Narcotic Antagonists; Prolactin; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2005 |
Functional mu opioid receptors are expressed in cholinergic interneurons of the rat dorsal striatum: territorial specificity and diurnal variation.
Topics: Acetylcholine; Analgesics, Opioid; Animals; Blotting, Northern; Choline O-Acetyltransferase; Circadian Rhythm; Corpus Striatum; Drug Interactions; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Excitatory Amino Acid Agonists; Immunohistochemistry; In Vitro Techniques; Interneurons; Limbic System; Membrane Potentials; N-Methylaspartate; Naltrexone; Narcotic Antagonists; Patch-Clamp Techniques; Potassium; Protein Precursors; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Synaptosomes; Tritium | 2005 |
Interactions among mu- and delta-opioid receptors, especially putative delta1- and delta2-opioid receptors, promote dopamine release in the nucleus accumbens.
Topics: Analgesics, Opioid; Anesthetics, Local; Animals; Benzylidene Compounds; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Extracellular Space; Male; Microdialysis; Naloxone; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Somatostatin; Tetrodotoxin | 2005 |
Chronic pain induces anxiety with concomitant changes in opioidergic function in the amygdala.
Topics: Amygdala; Analgesics, Opioid; Analysis of Variance; Animals; Anxiety; Behavior, Animal; Benzamides; Chronic Disease; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Freund's Adjuvant; Guanosine 5'-O-(3-Thiotriphosphate); Injections, Intraventricular; Male; Maze Learning; Mice; Mice, Inbred C57BL; Naltrexone; Narcotic Antagonists; Narcotics; Pain; Pain Measurement; Piperazines; Protein Binding; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reaction Time; Sciatica; Somatostatin; Sulfur Isotopes; Time Factors; Tranquilizing Agents | 2006 |
Effects of the local administration of selective mu-, delta-and kappa-opioid receptor agonists on osteosarcoma-induced hyperalgesia.
Topics: Analgesics, Opioid; Animals; Bone Neoplasms; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Hyperalgesia; Mice; Morphinans; Naltrexone; Narcotic Antagonists; Osteosarcoma; Receptors, Opioid | 2005 |
Cannabidiol is an allosteric modulator at mu- and delta-opioid receptors.
Topics: Allosteric Regulation; Analgesics, Opioid; Animals; Cannabidiol; Cerebral Cortex; Dose-Response Relationship, Drug; Dronabinol; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu | 2006 |
Mu-opioid receptor cellular function in the nucleus accumbens is essential for hedonically driven eating.
Topics: Analgesics, Opioid; Animals; Autoradiography; Eating; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Food Preferences; Guanosine 5'-O-(3-Thiotriphosphate); Male; Microinjections; Naltrexone; Nucleus Accumbens; Peptide Fragments; Peptides; Rabbits; Receptors, G-Protein-Coupled; Receptors, Opioid, mu; Somatostatin; Sucrose | 2006 |
Opioid receptors in the nucleus accumbens regulate attentional learning in the blocking paradigm.
Topics: Analgesics, Opioid; Animals; Attention; Electroshock; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Learning; Male; Models, Animal; Morphine; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Physical Stimulation; Rats; Rats, Wistar; Receptors, Opioid | 2006 |
Reduction of lipopolysaccharide-induced interleukin-6 production by the kappa opioid U50,488 in a mouse monocyte-like cell line.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cell Line, Tumor; Cell Survival; Dactinomycin; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Gene Expression; Interleukin-6; Lipopolysaccharides; Mice; Monocytes; Naltrexone; Narcotic Antagonists; Oligopeptides; Receptors, Opioid, kappa; RNA Stability; Time Factors; Transcription, Genetic; Tumor Necrosis Factor-alpha | 2006 |
Chronic prevention of mu-opioid receptor (MOR) G-protein coupling in the pontine parabrachial nucleus persistently decreases consumption of standard but not palatable food.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Behavior, Animal; Circadian Rhythm; Eating; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Feeding Behavior; Food Preferences; GTP-Binding Proteins; Male; Naltrexone; Narcotic Antagonists; Pons; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Opioid, mu; Time Factors | 2006 |
Alkylation of opioid receptors by 5'-naltrindole-isothiocyanate injected into the nucleus accumbens of rats: receptor selectivity and anatomical diffusion.
Topics: Alkylation; Animals; Autoradiography; Binding, Competitive; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Isothiocyanates; Male; Naltrexone; Narcotic Antagonists; Narcotics; Nucleus Accumbens; Oligopeptides; Phosphatidylethanolamines; Radioligand Assay; Rats; Rats, Inbred F344; Receptors, Opioid, delta; Transferases | 2006 |
Nucleus accumbens opioids regulate flavor-based preferences in food consumption.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Behavior, Animal; Eating; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Feeding Behavior; Flavoring Agents; Male; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Rats; Rats, Long-Evans; Reinforcement, Psychology; Time Factors | 2006 |
Gene transcription alterations associated with decrease of ethanol intake induced by naltrexone in the brain of Wistar rats.
Topics: Alcohol Drinking; Analgesics, Opioid; Animals; Autoradiography; Brain Chemistry; Central Nervous System Depressants; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Ethanol; Guanosine 5'-O-(3-Thiotriphosphate); Image Processing, Computer-Assisted; In Situ Hybridization; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Transcription, Genetic | 2007 |
Different effects of opioid antagonists on mu-, delta-, and kappa-opioid receptors with and without agonist pretreatment.
Topics: Benzylidene Compounds; Cells, Cultured; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Morphine; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Signal Transduction | 2007 |
Nucleus accumbens opioid signaling conditions short-term flavor preferences.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Behavior, Animal; Conditioning, Operant; Eating; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Food Preferences; GABA Agonists; Male; Morphine; Muscimol; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Rats; Rats, Long-Evans; Signal Transduction; Taste; Time Factors | 2007 |
The in vitro pharmacology of the peripherally restricted opioid receptor antagonists, alvimopan, ADL 08-0011 and methylnaltrexone.
Topics: Analgesics, Opioid; Animals; Benzeneacetamides; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Morphine; Muscle Contraction; Naltrexone; Narcotic Antagonists; Oligopeptides; Piperidines; Pyrrolidines; Quaternary Ammonium Compounds; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Proteins; Transfection | 2007 |
Endogenous dynorphin in epileptogenesis and epilepsy: anticonvulsant net effect via kappa opioid receptors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzamides; Cell Count; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Epilepsy, Temporal Lobe; Guanidines; Hippocampus; Kindling, Neurologic; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphinans; Naltrexone; Nerve Degeneration; Piperazines; Protein Precursors; Receptors, Opioid, kappa; Synaptic Transmission; Time Factors | 2007 |
Lobeline, a potential pharmacotherapy for drug addiction, binds to mu opioid receptors and diminishes the effects of opioid receptor agonists.
Topics: Analgesics, Opioid; Animals; Binding, Competitive; Brain; Dopamine; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Guinea Pigs; In Vitro Techniques; Lobeline; Mecamylamine; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Nicotine; Oocytes; Radioligand Assay; Receptors, Opioid; Receptors, Opioid, mu; Xenopus laevis | 2007 |
Attenuation of vascular permeability by methylnaltrexone: role of mOP-R and S1P3 transactivation.
Topics: Analgesics, Opioid; Animals; Capillary Permeability; Cells, Cultured; Electrophysiology; Endothelial Cells; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Humans; Intracellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Protein Serine-Threonine Kinases; Quaternary Ammonium Compounds; Receptors, Lysosphingolipid; Receptors, Opioid, mu; rho-Associated Kinases; rhoA GTP-Binding Protein; RNA, Small Interfering; Thrombin; Transcriptional Activation | 2007 |
Paraventricular opioids alter intake of high-fat but not high-sucrose diet depending on diet preference in a binge model of feeding.
Topics: Analgesics, Opioid; Animals; Bulimia Nervosa; Diet; Dietary Fats; Dose-Response Relationship, Drug; Eating; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Food Preferences; Homeostasis; Injections, Subcutaneous; Male; Naltrexone; Narcotic Antagonists; Paraventricular Hypothalamic Nucleus; Rats; Rats, Sprague-Dawley; Reward; Sucrose | 2007 |
Presynaptic actions of opioid receptor agonists in ventromedial hypothalamic neurons in estrogen- and oil-treated female mice.
Topics: Analgesics, Opioid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Estradiol; Estrogens; Excitatory Postsynaptic Potentials; Female; In Vitro Techniques; Mice; Naltrexone; Narcotic Antagonists; Neural Inhibition; Neurons; Oils; Ovariectomy; Patch-Clamp Techniques; Presynaptic Terminals; Ventromedial Hypothalamic Nucleus | 2008 |
Morphine-nicotine interaction in conditioned place preference in mice after chronic nicotine exposure.
Topics: Analgesics, Opioid; Animals; Autoradiography; Conditioning, Operant; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Nicotine; Nicotinic Agonists; Receptors, Opioid, mu | 2008 |
The spinal antinociceptive effects of endomorphins in rats: behavioral and G protein functional studies.
Topics: Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Partial Agonism; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Guanosine 5'-O-(3-Thiotriphosphate); Injections, Spinal; Male; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Spinal Cord; Sulfur Radioisotopes; Thalamus; Time Factors | 2008 |
Possible involvement of dynorphin A release via mu1-opioid receptor on supraspinal antinociception of endomorphin-2.
Topics: Analgesics; Animals; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Immune Sera; Injections, Intraventricular; Male; Mice; Naloxone; Naltrexone; Oligopeptides; Protein Precursors; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2008 |
Acute delta- and kappa-opioid agonist pretreatment potentiates opioid antagonist-induced suppression of water consumption.
Topics: Analgesics, Opioid; Animals; Benzamides; Benzomorphans; Discrimination, Psychological; Dose-Response Relationship, Drug; Drinking; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Injections, Subcutaneous; Male; Naltrexone; Narcotic Antagonists; Pain Measurement; Piperazines; Pyrrolidines; Rats; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Water Deprivation | 2008 |
Morphine attenuates the expression of sensitization to ethanol, but opioid antagonists do not.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Autoradiography; Behavior, Animal; Brain; Central Nervous System Depressants; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Ethanol; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Protein Binding; Rats; Rats, Wistar; Tritium | 2008 |
[Analysis of central mechanisms involved in gastric mucosal integrity].
Topics: Animals; Arachidonic Acids; beta-Endorphin; Clonidine; Endocannabinoids; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Ethanol; Excitatory Amino Acids; Gastric Mucosa; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Neurotransmitter Agents; Nociceptin; Oligopeptides; Opioid Peptides; Oxazoles; Polyunsaturated Alkamides; Rats; Rats, Wistar; Receptors, Opioid; Rilmenidine; Stomach Ulcer | 2008 |
Amygdalar opioids modulate hypothalamic melanocortin-induced anorexia.
Topics: alpha-MSH; Amygdala; Analgesics, Opioid; Animals; Appetite Regulation; Drug Interactions; Eating; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Food Deprivation; Hormones; Male; Melanocortins; Naltrexone; Neural Pathways; Neurotransmitter Agents; Paraventricular Hypothalamic Nucleus; Peptides, Cyclic; Rats; Rats, Sprague-Dawley; Receptor, Melanocortin, Type 3; Receptor, Melanocortin, Type 4; Receptors, Opioid, mu | 2009 |
Neutral antagonist activity of naltrexone and 6beta-naltrexol in naïve and opioid-dependent C6 cells expressing a mu-opioid receptor.
Topics: Adenylyl Cyclases; Animals; Binding, Competitive; Cell Line; Cell Line, Tumor; Cyclic AMP; Drug Inverse Agonism; Drug Partial Agonism; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Humans; Morphine; Naloxone; Naltrexone; Peptide Fragments; Piperidines; Radioligand Assay; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Somatostatin | 2009 |
Shadows across mu-Star? Constitutively active mu-opioid receptors revisited.
Topics: Adenylyl Cyclases; Animals; Binding, Competitive; Cell Line; Cell Line, Tumor; Drug Inverse Agonism; Drug Partial Agonism; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Humans; Morphine; Naltrexone; Radioligand Assay; Rats; Receptors, Opioid, mu | 2009 |
The unconditioned fear produced by morphine withdrawal is regulated by mu- and kappa-opioid receptors in the midbrain tectum.
Topics: Analgesics, Opioid; Animals; Catheterization; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Escape Reaction; Fear; Freezing Reaction, Cataleptic; Male; Microinjections; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid, kappa; Receptors, Opioid, mu; Substance Withdrawal Syndrome; Tectum Mesencephali | 2009 |
Feeding association between the nucleus of the solitary tract and the ventral tegmental area.
Topics: Animals; Eating; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Solitary Nucleus; Ventral Tegmental Area | 2009 |
Novel approach to demonstrate high efficacy of mu opioids in the rat vas deferens: a simple model of predictive value.
Topics: Analgesics, Opioid; Animals; Brain; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Male; Mice; Mice, Inbred Strains; Models, Biological; Morphine; Morphine Derivatives; Naltrexone; Oxymorphone; Pain; Rats; Rats, Wistar; Receptors, Opioid, mu; Vas Deferens | 2010 |
The role of nucleus accumbens adenosine-opioid interaction in mediating palatable food intake.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Catheterization; Central Nervous System Agents; Dietary Fats; Eating; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Locomotion; Male; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Phenethylamines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Receptor, Adenosine A2A; Receptors, Opioid, mu; Xanthines | 2010 |
Mu and kappa opioids modulate mouse embryonic stem cell-derived neural progenitor differentiation via MAP kinases.
Topics: Analgesics, Opioid; Animals; Antigens; Benzeneacetamides; Cell Differentiation; Cells, Cultured; Drug Interactions; Embryo, Mammalian; Embryonic Stem Cells; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enzyme Inhibitors; Glial Fibrillary Acidic Protein; Mice; Mitogen-Activated Protein Kinase Kinases; Naltrexone; Narcotic Antagonists; Oligodendroglia; Peptides; Proteoglycans; Pyrrolidines; Receptors, Opioid, kappa; Receptors, Opioid, mu; Time Factors; Tretinoin; Tubulin | 2010 |
Ex vivo delta opioid receptor autoradiography: CNS receptor occupancy of two novel compounds over their antihyperalgesic dose range.
Topics: Analgesics, Opioid; Animals; Autoradiography; Azabicyclo Compounds; Corpus Striatum; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Guanosine 5'-O-(3-Thiotriphosphate); Lumbar Vertebrae; Male; Naltrexone; Pain Measurement; Pyrimidines; Pyrrolidines; Radiography; Radioligand Assay; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord; Xanthenes | 2010 |
micro-Opioid receptor stimulation in the medial subnucleus of the tractus solitarius inhibits gastric tone and motility by reducing local GABA activity.
Topics: Animals; Down-Regulation; Efferent Pathways; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Gastric Fundus; Gastrointestinal Motility; Male; Microinjections; Muscle Tonus; Naltrexone; Narcotic Antagonists; Neurotransmitter Agents; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Opioid; Solitary Nucleus; Stomach; Vagus Nerve | 2010 |
The μ-opioid receptor variant N190K is unresponsive to peptide agonists yet can be rescued by small-molecule drugs.
Topics: Amino Acid Substitution; Black or African American; Cell Line; Cholesterol, HDL; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Female; Genes, Reporter; Genotype; Humans; Luciferases; Mutagenesis, Site-Directed; Mutation, Missense; Naloxone; Naltrexone; Narcotic Antagonists; Opioid Peptides; Peptides; Polymorphism, Single Nucleotide; Protein Isoforms; Protein Transport; Radioligand Assay; Receptors, Opioid, mu; Signal Transduction; White People | 2010 |
Tolerance to the antinociceptive effect of morphine in the absence of short-term presynaptic desensitization in rat periaqueductal gray neurons.
Topics: Analgesics; Animals; Drug Tolerance; Electrophysiological Phenomena; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Inhibitory Postsynaptic Potentials; Male; Morphine; Naltrexone; Neurons; Pain Measurement; Patch-Clamp Techniques; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid, mu; Signal Transduction | 2010 |
Basolateral amygdala opioids contribute to increased high-fat intake following intra-accumbens opioid administration, but not following 24-h food deprivation.
Topics: Amygdala; Analgesics, Opioid; Animals; Behavior, Animal; Diet; Dietary Fats; Eating; Energy Metabolism; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Food Deprivation; Male; Microinjections; Motor Activity; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Synaptic Transmission | 2010 |
μ-Opioid receptors in the nucleus accumbens shell region mediate the effects of amphetamine on inhibitory control but not impulsive choice.
Topics: Amphetamine; Analgesics, Opioid; Animals; Attention; Central Nervous System Stimulants; Choice Behavior; Conditioning, Operant; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Impulsive Behavior; Inhibition, Psychological; Male; Motivation; Naloxone; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Peptides; Rats; Rats, Wistar; Reaction Time; Receptors, Opioid, mu; Reinforcement Schedule | 2011 |
Differential expression and sensitivity of presynaptic and postsynaptic opioid receptors regulating hypothalamic proopiomelanocortin neurons.
Topics: Analgesics; Analgesics, Opioid; Analysis of Variance; Animals; Benzeneacetamides; Dizocilpine Maleate; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Gene Expression; Hypothalamus; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Luminescent Proteins; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Transgenic; Naltrexone; Narcotic Antagonists; Neural Inhibition; Neurons; Patch-Clamp Techniques; Peptide Fragments; Pro-Opiomelanocortin; Pyrrolidines; Quinoxalines; Receptors, Opioid; Somatostatin; Synapses | 2011 |
Micro-opioid receptor activation in the basolateral amygdala mediates the learning of increases but not decreases in the incentive value of a food reward.
Topics: Amygdala; Animals; Conditioning, Operant; Drive; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Food; Guanidines; Male; Microinjections; Morphinans; Naltrexone; Narcotic Antagonists; Neuropsychological Tests; Rats; Rats, Long-Evans; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reward; Somatostatin; Sucrose | 2011 |
Involvement of the lateral amygdala in the antiallodynic and reinforcing effects of heroin in rats after peripheral nerve injury.
Topics: Amygdala; Analgesics, Opioid; Animals; Behavior, Animal; Brain; Conditioning, Operant; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Guanosine 5'-O-(3-Thiotriphosphate); Heroin; Hyperalgesia; Infusions, Intravenous; Male; Naltrexone; Narcotic Antagonists; Peripheral Nerve Injuries; Rats; Rats, Inbred F344; Reinforcement, Psychology; Self Administration; Spinal Nerves | 2011 |
Nucleus accumbens facilitates nociception.
Topics: Analysis of Variance; Animals; Electrodes, Implanted; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Injections, Spinal; Lidocaine; Male; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Pain; Pain Measurement; Pain Perception; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Somatostatin; Spinal Cord | 2011 |
Opioidergic modulation of ethanol self-administration in the ventral pallidum.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Alcohol Drinking; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Globus Pallidus; Male; Microinjections; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Self Administration; Somatostatin | 2012 |
Pain-facilitating medullary neurons contribute to opioid-induced respiratory depression.
Topics: Analgesics, Opioid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Evoked Potentials; Male; Medulla Oblongata; Morphine; Naltrexone; Narcotic Antagonists; Neurons; Nociception; Nociceptive Pain; Rats; Rats, Sprague-Dawley; Respiratory Insufficiency | 2012 |
Effects of κ- and μ-opioid agonists on cholinergic neurotransmission and contraction in isolated bovine trachealis.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetylcholine; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Atropine; Cattle; Drug Interactions; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; In Vitro Techniques; Muscarinic Agonists; Muscarinic Antagonists; Muscle Contraction; Naltrexone; Narcotic Antagonists; Pilocarpine; Receptors, Opioid, kappa; Receptors, Opioid, mu; Trachea; Tritium | 2013 |
Increased agonist affinity at the μ-opioid receptor induced by prolonged agonist exposure.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Arrestin; Cell Membrane; Cells, Cultured; Dose-Response Relationship, Drug; Embryo, Mammalian; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Fibroblasts; Gene Expression; Guanosine 5'-O-(3-Thiotriphosphate); HEK293 Cells; Humans; Ligands; Mice; Mice, Knockout; Morphine; Naltrexone; Narcotic Antagonists; Opioid Peptides; Organic Chemicals; Pertussis Toxin; Pharmacological Phenomena; Protein Binding; Protein Conformation; Radioligand Assay; Receptors, Opioid, mu; Substrate Specificity; Time Factors; Transfection; Tritium | 2013 |
Differential control of opioid antinociception to thermal stimuli in a knock-in mouse expressing regulator of G-protein signaling-insensitive Gαo protein.
Topics: Analgesics, Opioid; Animals; Brain; Diprenorphine; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Excitatory Amino Acid Antagonists; Female; GABA Antagonists; gamma-Aminobutyric Acid; Gene Expression Regulation; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine 5'-O-(3-Thiotriphosphate); Hot Temperature; Humans; Hyperalgesia; Inhibitory Postsynaptic Potentials; Isotopes; Male; Methadone; Mice; Mice, Transgenic; Morphine; Mutation; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Oligopeptides; Pain Measurement; Patch-Clamp Techniques; Pertussis Toxin; Protein Binding; Reaction Time; RGS Proteins; Signal Transduction; Spinal Cord | 2013 |
In vitro binding affinities of a series of flavonoids for μ-opioid receptors. Antinociceptive effect of the synthetic flavonoid 3,3-dibromoflavanone in mice.
Topics: Acetic Acid; Analgesics; Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Compounding; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Flavanones; Flavonoids; Gastrointestinal Transit; Male; Maze Learning; Mice; Motor Activity; Naltrexone; Narcotic Antagonists; Pain Measurement; Protein Binding; Receptors, Opioid, mu; Tritium; Visceral Pain | 2013 |
Behavioral and neurochemical characterization of kratom (Mitragyna speciosa) extract.
Topics: Administration, Oral; Animals; Anxiety; Behavior, Animal; Blotting, Western; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; HEK293 Cells; Hot Temperature; Humans; Injections, Intraperitoneal; Injections, Intraventricular; Mice; Mice, Knockout; Mitragyna; Naltrexone; Narcotic Antagonists; Pain Threshold; Plant Extracts; Receptors, Dopamine D1; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2014 |
Central amygdala opioid transmission is necessary for increased high-fat intake following 24-h food deprivation, but not following intra-accumbens opioid administration.
Topics: Amygdala; Analgesics, Opioid; Animals; Diet, High-Fat; Eating; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Feeding Behavior; Food Deprivation; Male; Microinjections; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Time Factors | 2014 |
Characterization of BU09059: a novel potent selective κ-receptor antagonist.
Topics: Animals; Cell Line, Tumor; CHO Cells; Cricetulus; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Guanidines; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Isoquinolines; Male; Mice; Mice, Inbred Strains; Molecular Structure; Morphinans; Naltrexone; Narcotic Antagonists; Nociception; Piperidines; Rats; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tetrahydroisoquinolines; Vas Deferens | 2014 |
Prolonged morphine treatment alters δ opioid receptor post-internalization trafficking.
Topics: Analgesics, Opioid; Animals; Benzamides; Cells, Cultured; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Ganglia, Spinal; Male; Mice, Knockout; Morphine; Naltrexone; Neurons; Oligopeptides; Piperazines; Protein Transport; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu | 2015 |
Opposite effects of neuropeptide FF on central antinociception induced by endomorphin-1 and endomorphin-2 in mice.
Topics: Adamantane; Animals; Benzeneacetamides; Dipeptides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Injections, Intraventricular; Male; Mice; Naltrexone; Nociception; Oligopeptides; Pyrrolidines | 2014 |
The effects of nucleus accumbens μ-opioid and adenosine 2A receptor stimulation and blockade on instrumental learning.
Topics: Analgesics, Opioid; Animals; Conditioning, Operant; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Male; Microinjections; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Receptors, Opioid, mu; Time Factors | 2014 |
Brainstem opioidergic system is involved in early response to experimental SAH.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Cerebrovascular Circulation; Disease Models, Animal; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Gene Expression Regulation; Medulla Oblongata; Microinjections; Naltrexone; Narcotic Antagonists; Opioid Peptides; Phosphopyruvate Hydratase; Rats; Rats, Sprague-Dawley; Ribosome Inactivating Proteins, Type 1; Saporins; Subarachnoid Hemorrhage; Time Factors | 2015 |
Mu opioid receptor modulation in the nucleus accumbens lowers voluntary wheel running in rats bred for high running motivation.
Topics: Analgesics, Opioid; Animals; Animals, Outbred Strains; Dose-Response Relationship, Drug; Eating; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Motivation; Motor Activity; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Protein Precursors; Rats, Wistar; Receptors, Opioid, mu; RNA, Messenger; Running; Species Specificity | 2015 |
The novel mu-opioid antagonist, GSK1521498, reduces ethanol consumption in C57BL/6J mice.
Topics: Alcohol Drinking; Alcoholism; Animals; Autoradiography; Behavior, Animal; Central Nervous System Depressants; Cross-Over Studies; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Ethanol; Indans; Male; Mice; Mice, Inbred C57BL; Naltrexone; Narcotic Antagonists; Radiopharmaceuticals; Receptors, Opioid, mu; Self Administration; Triazoles; Tritium | 2015 |
Maturational alterations in constitutive activity of medial prefrontal cortex kappa-opioid receptors in Wistar rats.
Topics: Age Factors; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Guanosine 5'-O-(3-Thiotriphosphate); Male; Naltrexone; Narcotic Antagonists; Prefrontal Cortex; Protein Binding; Radionuclide Imaging; Rats; Rats, Wistar; Receptors, Opioid, kappa; Somatostatin; Sulfur Isotopes | 2015 |
Mu-opioid receptor inhibition decreases voluntary wheel running in a dopamine-dependent manner in rats bred for high voluntary running.
Topics: Animals; Cells, Cultured; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Feeding Behavior; Female; Injections, Intraperitoneal; Motivation; Motor Activity; Naltrexone; Narcotic Antagonists; Neurons; Nucleus Accumbens; Oxidopamine; Rats; Receptors, Opioid, mu; RNA, Messenger; Running; Sedentary Behavior; Species Specificity; Volition | 2016 |
Mu Opioid Receptor Agonist DAMGO Produces Place Conditioning, Abstinence-induced Withdrawal, and Naltrexone-Dependent Locomotor Activation in Planarians.
Topics: Analgesics, Opioid; Animals; Conditioning, Psychological; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Locomotion; Naltrexone; Narcotic Antagonists; Planarians; Receptors, Opioid, mu; Substance Withdrawal Syndrome | 2018 |
Pharmacological Characterization of Dezocine, a Potent Analgesic Acting as a κ Partial Agonist and μ Partial Agonist.
Topics: Analgesics, Opioid; Animals; Bridged Bicyclo Compounds, Heterocyclic; CHO Cells; Cricetulus; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Female; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Nociception; Pain Measurement; Protein Binding; Receptors, Opioid, kappa; Receptors, Opioid, mu; Signal Transduction; Tetrahydronaphthalenes | 2018 |
Cardioprotective properties of opioid receptor agonists in rats with stress-induced cardiac injury.
Topics: Analgesics, Opioid; Animals; Cardiotonic Agents; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Heart Diseases; Immobilization; Male; Myocardium; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid, mu; Stress, Psychological | 2019 |
Opioid-Mediated Astrocyte-Neuron Signaling in the Nucleus Accumbens.
Topics: Analgesics, Opioid; Animals; Astrocytes; Calcium; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Glial Fibrillary Acidic Protein; Inositol 1,4,5-Trisphosphate Receptors; Membrane Potentials; Mice, Inbred C57BL; Naltrexone; Neurons; Receptors, Opioid, mu; Signal Transduction | 2019 |
Single-molecule analysis reveals agonist-specific dimer formation of µ-opioid receptors.
Topics: Animals; beta-Arrestins; CHO Cells; Cricetulus; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Fluorescence Resonance Energy Transfer; Morphine; Mutation; Naloxone; Naltrexone; Narcotic Antagonists; Phosphorylation; Protein Multimerization; Receptors, Opioid, mu; Single Molecule Imaging | 2020 |