naltrexone has been researched along with dynorphins in 226 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 25 (11.06) | 18.7374 |
| 1990's | 102 (45.13) | 18.2507 |
| 2000's | 62 (27.43) | 29.6817 |
| 2010's | 32 (14.16) | 24.3611 |
| 2020's | 5 (2.21) | 2.80 |
| Authors | Studies |
|---|---|
| Caudle, RM; Chavkin, C; Wagner, JJ | 1 |
| Fujimoto, JM; Holmes, BB | 2 |
| Bodnar, RJ; Kest, B; Orlowski, M | 1 |
| Ingenito, AJ; Wang, JQ | 4 |
| Song, SH; Takemori, AE | 1 |
| Bennett, EL; Colombo, PJ; Martinez, JL; Rosenzweig, MR | 1 |
| Adler, MW; Geller, EB; Handler, CM | 1 |
| Katafuchi, T; Koizumi, K; Nagatomo, I | 1 |
| Bakshi, R; Faden, AI; Ni, RX | 1 |
| Furuya, Y; Kaneko, T; Nakazawa, T; Yamatsu, K | 1 |
| Song, ZH; Takemori, AE | 1 |
| Adams, JU; Holtzman, SG | 1 |
| de Jong, W; de Lang, H; van Giersbergen, PL | 1 |
| Butler, B; Gunion, MW; Miller, S; Moore, RD; Morley, JE; Rosenthal, MJ; Zib, B | 1 |
| Shiotsu, G; Stein, L; Stevens, KE | 1 |
| Gannon, RL; Terrian, DM | 1 |
| Cohen, Y; Jacquot, C; Orosco, M; Robert, JJ; Rouch, C | 1 |
| Barnes, MI; Hong, JS; Hudson, PM; Mitchell, CL | 1 |
| Como, PG; Deeley, C; Kurlan, R; Majumdar, L; Mudholkar, GS; Plumb, S | 1 |
| Godin, C; Henry, JL; Rochford, J | 1 |
| Faden, AI | 1 |
| Arts, KS; Fujimoto, JM | 1 |
| Koehler, E; McLemore, GL; Rosella-Dampman, LM; Summy-Long, JY | 1 |
| Bakshi, R; Faden, AI; Newman, AH | 1 |
| Dixon, DM; Traynor, JR | 1 |
| Conti, A; Maestroni, GJ | 1 |
| Candeletti, S; Cavicchini, E; Ferri, S; Spampinato, S | 1 |
| de Costa, B; Long, JB; Martinez-Arizala, A; Rice, KC; Rigamonti, DD | 1 |
| Fujimoto, JM; Rady, JJ | 2 |
| Bloom, FE; Chavkin, C; Henriksen, SJ; Siggins, GR | 1 |
| Baskin, DS; Hosobuchi, Y; Kuroda, H; Lee, NM | 1 |
| Di Chiara, G; Morelli, M | 1 |
| Bloom, FE; Chavkin, C | 1 |
| Akil, H; Houghten, RA; Lewis, ME; Walker, JM; Woods, JH; Young, EA | 1 |
| Herz, A; Millan, MH; Millan, MJ; Reid, LD | 1 |
| Ding, XZ; Fan, SG; Han, JS | 1 |
| Lipkowski, AW; Portoghese, PS; Takemori, AE | 1 |
| Gosnell, BA; Grace, M; Levine, AS | 1 |
| McLean, S; Rothman, RB | 1 |
| Schwyzer, R | 1 |
| Burks, TF; Galligan, JJ | 1 |
| Huidobro-Toro, JP; Way, EL; Yoshimura, K | 1 |
| Chavkin, C; Goldstein, A; James, IF | 1 |
| Chavkin, C; Cox, BM | 1 |
| Herz, A; Millan, MH; Millan, MJ; Przewłocki, R | 1 |
| Fischli, W; Goldstein, A; James, IF | 1 |
| Bajorek, JG; Lee, RJ; Lomax, P | 1 |
| Herz, A; Schulz, R; Wüster, M | 1 |
| Billington, CJ; Gosnell, BA; Levine, AS; Morley, JE | 1 |
| Chavkin, C; Goldstein, A | 1 |
| Hiramatsu, M; Kameyama, T; Sasaki, M | 1 |
| Armstead, WM | 2 |
| Chen, L; Gu, Y; Huang, LY | 1 |
| Han, JS; Jen, MF; Xue, JC; Yu, YX | 1 |
| Chavkin, C; Gibbs, SM; Simmons, ML; Terman, GW | 1 |
| Kuznetsov, A; Ma, GH; Miller, RJ; Philipson, LH | 1 |
| Angel, F; Baumann, R; Chamouard, P; Meyer, C; Rohr, S | 1 |
| Ingenito, AJ; Wong, SC | 1 |
| Grudt, TJ; Williams, JT | 1 |
| al-Dokhayel, AA; Bloom, SR; Gilbey, SG; Lambert, PD; Wilding, JP | 1 |
| Funada, M; Misawa, M; Nagase, H; Narita, M; Suzuki, T | 1 |
| Lookingland, KJ; Manzanares, J; Moore, KE; Wagner, EJ | 1 |
| de Costa, BR; Orlowski, M; Petrov, ES; Rice, KC; Robinson, SR; Smotherman, WP; Varlinskaya, EI | 1 |
| Dickenson, AH; Stanfa, LC | 1 |
| Chavkin, C; Terman, GW; Wagner, JJ | 2 |
| Isaac, L; Ristic, H | 1 |
| Macdonald, RL; Moises, HC; Rusin, KI | 1 |
| Kishioka, S; Masuda, Y; Miyamoto, Y; Ozaki, M; Yamamoto, H | 1 |
| Kameyama, T; Mizutani, M; Ukai, M | 1 |
| Chen, C; DeRiel, JK; Kunapuli, S; Liu-Chen, LY; Xue, JC; Yu, L; Zhu, J | 1 |
| al-Dokhayel, AA; Bloom, SR; Bohuon, C; Comoy, E; Gilbey, SG; Lambert, PD; Wilding, JP | 1 |
| Dewey, WL; Smith, FL | 1 |
| Aksu, F; Fujimoto, JM; Holmes, BB | 1 |
| Itoh, J; Kameyama, T; Ukai, M | 1 |
| Bidlack, JM; Lawrence, DM | 1 |
| Adloff, M; Angel, F; Chamouard, P; Klein, A; Martin, E | 1 |
| Hong, X; Li, B; Li, M | 1 |
| Brandt, MR; France, CP | 2 |
| Kameyama, T; Toyoshi, T; Ukai, M | 1 |
| Hong, X; Li, M; Yang, Y | 1 |
| Fuentes, JA; Reche, I; Ruiz-Gayo, M | 1 |
| Misawa, M; Nagase, H; Suzuki, T; Tsuda, M | 1 |
| Kavaliers, M; Perrot-Sinal, TS | 1 |
| Butour, JL; Meunier, JC; Moisand, C; Mollereau, C; Parmentier, M | 1 |
| Durham, RA; Johnson, JD; Lookingland, KJ; Moore, KE | 1 |
| Kameyama, T; Kobayashi, T; Shan-Wu, X; Ukai, M | 1 |
| Kübler, W; Mura, RA; Niroomand, F; Piacentini, L | 1 |
| Akil, H; Ardati, A; Civelli, O; Hoversten, MT; Meng, F; Monsma, FJ; Reinscheid, RK; Taylor, LP; Ueda, Y; Watson, SJ | 1 |
| Conti, A; Galli, P; Hertens, E; Maestroni, GJ; Pedrinis, E | 1 |
| Hiramatsu, M; Kameyama, T; Nabeshima, T; Sasaki, M | 1 |
| Hong, JS; Hudson, PM; Jin, L; Kong, LY; McMillian, MK | 1 |
| Itoh, J; Kameyama, T; Kobayashi, T; Shinkai, N; Ukai, M | 1 |
| Gross, RA; MacDonald, RL; Moises, HC; Wiley, JW | 1 |
| Goldstein, BD; Zachariou, V | 1 |
| Billington, CJ; Kotz, CM; Levine, AS | 1 |
| Welch, SP | 1 |
| Lishmanov, YB; Maslov, LN; Smagin, GN; Ugdyzhekova, DS | 1 |
| Lishmanov, IB; Maslov, LN; Ugdyzhekova, DS | 1 |
| Adams, DJ; Trequattrini, C | 1 |
| Fujimoto, JM; Holmes, BB; Rady, JJ | 1 |
| Georgieva, J; Nylander, I; Ogren, SO; Sandin, J; Schött, PA; Terenius, L | 1 |
| Gu, Y; Huang, LY; Lai, SL | 1 |
| Andoh, T; Ito, H; Kamiya, Y; Oka, K; Watanabe, I | 1 |
| Brown, CH; Leng, G; Ludwig, M | 2 |
| Foxx-Orenstein, AE; Grider, JR; Jin, JG | 1 |
| Brodkin, ES; Carlezon, WA; Duman, RS; Hiroi, N; Lane-Ladd, SB; Nestler, EJ; Neve, RL; Olson, VG; Thome, J | 1 |
| Borg, L; Gunduz, M; Ho, A; Kreek, MJ; Schluger, J | 1 |
| Liu, H; Mazarati, A; Wasterlain, C | 1 |
| Arcaya, JL; Cano, G; Gómez, G; Maixner, W; Suárez-Roca, H | 1 |
| Butelman, ER; Ko, MC; Woods, JH | 1 |
| Goto, K; Ishige, A; Komatsu, Y; Omiya, Y; Suzuki, Y | 1 |
| Maslov, LN; Naryzhnaya, NV; Tam, SW | 1 |
| Herrera-Marschitz, M; Terenius, L; You, ZB | 1 |
| Lowe, J; Mason, DJ; Welch, SP | 1 |
| Maestroni, GJ; Pedrinis, E; Zammaretti, F | 1 |
| Butelman, ER; Harris, TJ; Kreek, MJ | 1 |
| Foldes, JK; Hauser, KF; Turbek, CS | 1 |
| Lin, BC; Ni, X; Song, CY; Wang, CH | 1 |
| Hiramatsu, M; Inoue, K; Kameyama, T | 1 |
| Freeman, FM; Young, IG | 1 |
| Clark, WM; Kelly, RE; Raps, EC; Tong, DC | 1 |
| Ballet, S; Cesselin, F; Collin, E; Hamon, M; Mauborgne, A | 1 |
| Inoue, M; Kisara, K; Nakagawasai, O; Niijima, F; Nylander, I; Ohshima, K; Silberring, J; Tadano, T; Taira, A; Tan-No, K; Terenius, L | 1 |
| Portoghese, PS | 1 |
| Cowen, MS; Lawrence, AJ | 1 |
| Fujimura, T; Hayashi, T; Kastin, AJ; Murayama, K; Narita, M; Orito, T; Sakurada, C; Sakurada, S; Sakurada, T; Suzuki, T; Tan-no, K; Tseng, LF; Yuhki, M; Zadina, JE | 1 |
| Hung, KC; Mizoguchi, H; Nagase, H; Tseng, LF; Wu, HE | 1 |
| Bodnar, RJ; Grossman, HC; Hadjimarkou, MM; Pasternak, GW; Rossi, GC; Silva, RM | 1 |
| Ballet, S; Bourgoin, S; Braz, J; Cesselin, F; Hamon, M; Mauborgne, A; Zajac, JM | 1 |
| Billington, CJ; Briggs, JE; Glass, MJ; Kotz, CM; Levine, AS | 1 |
| McCormick, SE; Stoessl, AJ | 1 |
| Eggert, A; Fischer, WH; Kämpgen, E; Kirst, A; Lutz, WK; Wack, C | 1 |
| Gallo, RV; Zhang, Q | 1 |
| Bastia, E; Bertorelli, R; Citterio, F; Corradini, L; Forlani, A; Ongini, E | 1 |
| Armstead, WM; Kulkarni, M | 1 |
| Gardell, LR; Lai, J; Ossipov, MH; Porreca, F; Vanderah, TW | 1 |
| Chen, J; Duman, RS; Nestler, EJ; Neve, R; Newton, SS; Sakai, N; Schlesinger, L; Shirayama, Y; Thome, J; Wallace, TL | 1 |
| Liu, HX | 1 |
| Qian, X; Soong, Y; Szeto, HH; Wu, D; Zhao, GM | 1 |
| Lunzer, MM; Portoghese, PS | 1 |
| Cao, Z; Liu, L; Van Winkle, DM | 1 |
| Grillo, CA; Lucas, LR; McEwen, BS | 1 |
| Darpolar, M; Kampine, JP; Leitermann, RJ; Sun, HS; Tseng, LF; Wu, HE | 1 |
| Ball, JW; Butelman, ER; Kreek, MJ | 1 |
| Bernardi, G; D'Angelo, V; Lavaroni, F; Martella, G; Martorana, A; Spadoni, F; Stefani, A | 1 |
| Bieber, A; Chung, E; Day, E; Ohgami, Y; Quock, RM | 1 |
| Carlezon, WA; Marcus, JF; Portoghese, PS; Todtenkopf, MS | 1 |
| Clithero, AD; Hung, KC; Leitermann, RJ; Schwasinger, ET; Terashvili, M; Tseng, LF; Wu, HE | 1 |
| Gao, HM; Liu, H; Song, HS; Tang, YY; Zhang, WQ | 1 |
| Fujimoto, JM; Leitermann, RJ; Sun, HS; Thompson, J; Tseng, LF; Wu, HE | 1 |
| Berry, JA; Bolling, SF; McNish, RA; Romano, MA; Seymour, EM | 1 |
| Cox, ML; Welch, SP | 1 |
| Ise, Y; Kishimoto, Y; Misawa, K; Narita, M; Suzuki, T; Yajima, Y | 1 |
| Duman, RS; Hazama, GI; Ishida, H; Iwata, M; Kawahara, R; Shirayama, Y | 1 |
| Raffa, RB; Sterious, SN; Walker, EA | 1 |
| Kaneko, C; Kuzumaki, N; Matsuzawa, K; Miyoshi, K; Nagumo, Y; Nakajima, M; Nanjo, K; Narita, M; Suzuki, T; Yamazaki, M | 1 |
| Benabid, AL; Berger, F; Buggia, V; Gilbert, F; Lévesque, D; Sgambato-Faure, V | 1 |
| Adler, MW; Chen, X; Geller, EB; McClatchy, DB; Tallarida, RJ | 1 |
| Bakalkin, G; Kuzmin, A; Madjid, N; Ogren, SO; Terenius, L | 1 |
| Maldonado, R; Mendizábal, V; Zimmer, A | 1 |
| Hiramatsu, M; Watanabe, E | 1 |
| Chefer, VI; Shippenberg, TS | 1 |
| Buxbaum, JD; Cho, J; Jacobson, DA; Landa, LR; Philipson, LH; Roe, MW; Tamarina, NA | 1 |
| Qi, W; Smith, FG | 1 |
| Fobker, M; Grosse Hartlage, MA; Monteiro de Oliveira, NP; Theisen, MM; Van Aken, H; Weber, TP | 1 |
| Schwasinger, E; Terashvili, M; Tseng, LF; Wu, HE | 1 |
| Koob, GF; Walker, BM | 1 |
| Gintzler, AR; Liu, NJ; von Gizycki, H | 1 |
| Dahlin, I; Franck, J; Georgieva, J; Lindholm, S; Rosin, A | 1 |
| Chavkin, C; Gendron, L; Pintar, JE | 1 |
| Bruchas, MR; Chavkin, C; Land, BB; Lemos, JC; Melief, EJ; Xu, M | 1 |
| Komatsu, T; Mizoguchi, H; Morimoto, M; Sakurada, S; Sakurada, T; Sato, T; Sawai, T; Watanabe, C; Watanabe, H; Yonezawa, A | 1 |
| Barr, CS; Chen, SA; Cheng, K; Rice, KC; Riley, AL; Rinker, JA; Roma, PG; Serafine, KM | 1 |
| Ardell, JL; Ding, X; Hua, F; Sutherly, K; Williams, CA | 1 |
| Bruchas, MR; Chavkin, C; Xu, M | 1 |
| Gaburro, S; Herzog, H; Rosskothen, I; Schunk, E; Schwarzer, C; Singewald, N; Wittmann, W | 1 |
| Balog, T; Marotti, T; Martin-Kleiner, I | 1 |
| Chung, E; Ohgami, Y; Quock, RM; Shirachi, DY; Zelinski, LM | 1 |
| Charron, C; Hakim, AM; Plamondon, H; Proulx, G; Schock, SC; Thompson, CS | 1 |
| Di Paolo, T; Grégoire, L; Lévesque, D; Morissette, M; Ouattara, B; Rouillard, C; Samadi, P; Tamim, MK | 1 |
| Rai, U; Singh, R | 1 |
| Chavkin, C; Li, S; Schindler, AG | 1 |
| Koob, GF; Walker, BM; Zorrilla, EP | 1 |
| Dong, Y; Mu, P; Neumann, PA; Panksepp, J; Schlüter, OM | 1 |
| Cabañero, D; Campillo, A; García-Nogales, P; Puig, MM; Romero, A | 1 |
| Huang, W; Li, Q; Shu, H; Wu, G; Zhang, H; Zhou, J | 1 |
| McDermott, CM; Schrader, LA | 1 |
| Hamid, A; Lutfy, K; Marquez, P; Nguyen, K; Tseng, A | 1 |
| Goyal, R; Kumar, K; Mohan, A; Mudgal, A; Pasha, S | 1 |
| Chavkin, C; Chavkin, NW; Gustin, RM; Hagan, CE; Lemos, JC; Messinger, DI; Neumaier, JF; Schattauer, SS; Schindler, AG; Shankar, H; Smith, JS | 1 |
| Dunlop, SA; Farid, WO; Hulse, GK; Krstew, EV; Lawrence, AJ; Tait, RJ | 1 |
| Gillett, K; Harshberger, E; Valdez, GR | 1 |
| Deura, C; Fujii, N; Iwase, A; Kikkawa, F; Maeda, K; Minabe, S; Nakahara, T; Nakamura, S; Noguchi, T; Oishi, S; Tsukamura, H; Uenoyama, Y; Watanabe, Y | 1 |
| Bakalkin, G; Bazov, I; Chefer, V; Kuzmin, A; Meis, J; Ögren, SO; Shippenberg, T | 1 |
| Heeman, JH; Quock, RM; Shirachi, DY; Zhang, Y | 1 |
| Gilpin, NW; Koob, GF; Roberto, M; Schweitzer, P | 1 |
| Aldrich, JV; Cowan, A; Dimattio, KM; Liu-Chen, LY; Yakovleva, TV | 1 |
| Clark, JD; Liang, DY; Sahbaie, P; Shi, XY; Sun, Y | 1 |
| Nubukpo, P | 1 |
| Kelsey, JE; Schierberl, KC; Verhaak, AM | 1 |
| Cowan, A; Inan, S; Kehner, GB | 1 |
| Chen, Z; Li, C; Liu, Y; Tang, Y; Tao, H; Zhang, X | 1 |
| Katsuyama, S; Komatsu, T; Mizoguchi, H; Nagase, H; Sakurada, C; Sakurada, S; Sakurada, T; Tsuzuki, M | 1 |
| Aldrich, JV; Huang, P; Liu-Chen, LY; Parry, C; Tunis, J; Yakovleva, T | 1 |
| Bertram, R; Cristancho-Gordo, R; Gonzalez-Iglesias, AE; Helena, CV; Stathopoulos, AM | 1 |
| Bruchas, MR; Carlezon, WA; Hourguettes, NJ; Nygard, SK; Sobczak, GG | 1 |
| George, O; Kallupi, M; Martin-Fardon, R; Matzeu, A; Schweitzer, P | 1 |
| De Felice, M; Dodick, DW; Hernandez, PI; Nation, KM; Navratilova, E; Neugebauer, V; Porreca, F | 1 |
| Erikson, CM; Walker, BM; Wei, G | 1 |
| Anderson, RI; Becker, HC; Bloodgood, DW; Boyt, KM; Griffin, WC; Haun, HL; Kash, TL; Lopez, MF; Pati, D | 1 |
| Carson, RE; Chang, D; Foltin, R; Grassetti, A; Huang, Y; Lin, SF; Martinez, D; Matuskey, D; Nabulsi, N; Ropchan, J; Salling, M; Slifstein, M; Urban, N; Zheng, MQ | 1 |
| Chen, Q; He, W; Ivanova, D; Kuang, Y; Lass, G; Li, X; Liu, Y; Long, H; Lyu, Q; O'Byrne, KT; Wang, L; Wang, Y; Yu, S | 1 |
| Fan, W; Law, PY; Loh, HH; Xu, C; Zhang, Y | 1 |
| Chai, JR; Du, WJ; Guo, LB; Li, QL; Liu, JG; Liu, R; Liu, ZQ; Sun, X; Wang, CY; Wang, YJ; Zan, GY | 1 |
| Abraham, AD; Casello, SM; Chavkin, C; Land, BB; Mahe, K; Mizuno, GO; Schattauer, SS; Tian, L; Wong, BA | 1 |
| Al-Hasani, R; Conway, SM | 1 |
| Adapa, ID; Auh, JS; Berzetei-Gurske, IP; Brandt, SR; Craymer, K; Farrington, L; Haggart, D; Kennedy, JM; O'Brien, A; Polgar, WE; Rodriguez, L; Schwartz, RW; Toll, L; White, A | 1 |
2 review(s) available for naltrexone and dynorphins
| Article | Year |
|---|---|
[Place of the opioid system in biology and treatment of Alcohol Use Disorder].
Topics: Alcoholism; Brain; Craving; Diagnostic and Statistical Manual of Mental Disorders; Dynorphins; Endorphins; Humans; International Classification of Diseases; Naltrexone; Neurotransmitter Agents; Receptors, Opioid | 2014 |
Targeting Itch with Ligands Selective for κ Opioid Receptors.
Topics: Animals; Dynorphins; Guanidines; Humans; Ligands; Mice; Morphinans; Naltrexone; p-Methoxy-N-methylphenethylamine; Peptide Fragments; Pruritus; Receptors, Opioid, kappa; Spiro Compounds | 2015 |
3 trial(s) available for naltrexone and dynorphins
| Article | Year |
|---|---|
A controlled trial of propoxyphene and naltrexone in patients with Tourette's syndrome.
Topics: Adult; Attention; Dextropropoxyphene; Double-Blind Method; Dynorphins; Endorphins; Female; Humans; Male; Naltrexone; Receptors, Dopamine; Receptors, Opioid; Severity of Illness Index; Tourette Syndrome; Trail Making Test | 1991 |
Dynorphin A1-13 causes elevation of serum levels of prolactin through an opioid receptor mechanism in humans: gender differences and implications for modulation of dopaminergic tone in the treatment of addictions.
Topics: Adult; Analgesics, Opioid; Analysis of Variance; Cocaine-Related Disorders; Dose-Response Relationship, Drug; Dynorphins; Female; Humans; Male; Middle Aged; Naloxone; Naltrexone; Narcotic Antagonists; Peptide Fragments; Prolactin; Receptors, Dopamine; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sex Characteristics; Time Factors | 1999 |
Cervene (Nalmefene) in acute ischemic stroke : final results of a phase III efficacy study. The Cervene Stroke Study Investigators.
Topics: Acute Disease; Aged; Aged, 80 and over; Brain Ischemia; Dose-Response Relationship, Drug; Double-Blind Method; Dynorphins; Female; Humans; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Nausea; Neuroprotective Agents; Receptors, Opioid, kappa; Risk Factors; Survival Analysis; Treatment Failure | 2000 |
221 other study(ies) available for naltrexone and dynorphins
| Article | Year |
|---|---|
Kappa-opioids decrease excitatory transmission in the dentate gyrus of the guinea pig hippocampus.
Topics: Action Potentials; Animals; Benzeneacetamides; Diprenorphine; Dynorphins; Electrophysiology; Endorphins; Guinea Pigs; Hippocampus; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Synapses | 1992 |
Naloxone and norbinaltorphimine administered intracerebroventricularly antagonize spinal morphine-induced antinociception in mice through the antianalgesic action of spinal dynorphin A (1-17).
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Dynorphins; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Naltrexone | 1992 |
Endopeptidase 24.15 inhibition and opioid antinociception.
Topics: Amino Acid Sequence; Analgesics; Animals; Dynorphins; Enkephalin, Methionine; Male; Metalloendopeptidases; Molecular Sequence Data; Naltrexone; Narcotics; Pain Measurement; Protease Inhibitors; Rats; Rats, Inbred Strains; Reaction Time | 1992 |
Centrally mediated cardiovascular actions of dynorphin A(1-8) on rat hippocampal formation.
Topics: Animals; Blood Pressure; Dynorphins; Heart Rate; Hippocampus; Injections, Intraventricular; Lidocaine; Male; Naltrexone; Peptide Fragments; Rats; Rats, Inbred Strains; Respiration | 1992 |
Modulation of acute morphine tolerance by corticotropin-releasing factor and dynorphin A in the mouse spinal cord.
Topics: Animals; Corticotropin-Releasing Hormone; Drug Tolerance; Dynorphins; Injections, Spinal; Male; Mice; Morphine; Naltrexone; Peptide Fragments; Spinal Cord | 1992 |
Kappa opioid receptor activity modulates memory for peck-avoidance training in the 2-day-old chick.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Animals, Newborn; Avoidance Learning; Chickens; Dose-Response Relationship, Drug; Dynorphins; Male; Memory; Naltrexone; Peptide Fragments; Pyrrolidines; Receptors, Opioid, kappa | 1992 |
Effect of mu-, kappa-, and delta-selective opioid agonists on thermoregulation in the rat.
Topics: Amino Acid Sequence; Animals; Body Temperature; Body Temperature Regulation; Brain; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Indoles; Injections, Intraventricular; Male; Molecular Sequence Data; Morphinans; Naltrexone; Narcotic Antagonists; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1992 |
Effects of the opiates on the paraventricular nucleus in genetically polydipsic mice.
Topics: Animals; Dynorphins; Female; In Vitro Techniques; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Microinjections; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Neurons; Paraventricular Hypothalamic Nucleus; Quaternary Ammonium Compounds; Synapses; Thirst | 1992 |
N-methyl-D-aspartate (NMDA) and opioid receptors mediate dynorphin-induced spinal cord injury: behavioral and histological studies.
Topics: Animals; Dextrorphan; Dynorphins; Glial Fibrillary Acidic Protein; Immunohistochemistry; Infusions, Parenteral; Male; Motor Activity; N-Methylaspartate; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Serotonin; Silver Staining; Spinal Cord; Staining and Labeling | 1992 |
Spinal kappa receptor-mediated analgesia of E-2078, a systemically active dynorphin analog, in mice.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Dynorphins; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Peptide Fragments; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1991 |
Involvement of spinal kappa opioid receptors in the antagonistic effect of dynorphins on morphine antinociception.
Topics: Animals; Dynorphins; Indoles; Male; Mice; Morphinans; Morphine; Naltrexone; Pain; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Spine; Stereoisomerism | 1991 |
Naltrexone-sensitizing effects of centrally administered morphine and opioid peptides.
Topics: Animals; Conditioning, Operant; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Morphine; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta | 1991 |
Effects of dynorphin A(1-13) and of fragments of beta-endorphin on blood pressure and heart rate of anesthetized rats.
Topics: Anesthesia; Animals; beta-Endorphin; Blood Pressure; Dynorphins; Heart Rate; Injections, Intraventricular; Naltrexone; Narcotics; Peptide Fragments; Rats; Rats, Inbred Strains | 1991 |
mu-receptor mediates elevated glucose and corticosterone after third ventricle injection of opioid peptides.
Topics: Animals; beta-Endorphin; Blood Glucose; Cerebral Ventricles; Corticosterone; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Fatty Acids, Nonesterified; Injections, Intraventricular; Male; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu | 1991 |
Hippocampal mu-receptors mediate opioid reinforcement in the CA3 region.
Topics: Animals; Dynorphins; Enkephalin, Leucine; Hippocampus; Kinetics; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pyramidal Tracts; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Reference Values; Reinforcement, Psychology; Self Administration | 1991 |
U-50,488H inhibits dynorphin and glutamate release from guinea pig hippocampal mossy fiber terminals.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Calcium; Dynorphins; Enkephalin, Leucine; Glutamates; Guinea Pigs; Hippocampus; Kinetics; Naloxone; Naltrexone; Narcotic Antagonists; Nerve Endings; Potassium Chloride; Pyrrolidines; Synaptosomes | 1991 |
Effects of dexfenfluramine and opioid peptides, alone or in combination, on food intake and brain serotonin turnover in rats.
Topics: Animals; beta-Endorphin; Brain; Drug Interactions; Dynorphins; Eating; Endorphins; Enkephalin, Leucine; Female; Fenfluramine; Naltrexone; Rats; Rats, Inbred Strains; Serotonin | 1991 |
Opioid mu and delta receptor antagonists reduce wet dog shaking elicited by perforant path stimulation.
Topics: Animals; Dynorphins; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Methionine; gamma-Aminobutyric Acid; Hippocampus; Male; Naltrexone; Peptide Fragments; Rats; Rats, Inbred F344; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Stereotyped Behavior | 1991 |
Intrathecal administration of dynorphin A and its fragments increase heart rate and arterial pressure in the urethane anesthetized rat: mediation by a nonopioid mechanism.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Anesthesia, General; Animals; Antihypertensive Agents; Blood Pressure; Diastole; Dynorphins; Heart Rate; Hexamethonium; Hexamethonium Compounds; Injections, Intravenous; Injections, Spinal; Male; Naloxone; Naltrexone; Peptide Fragments; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Reference Values; Systole | 1991 |
Opioid and nonopioid mechanisms may contribute to dynorphin's pathophysiological actions in spinal cord injury.
Topics: Animals; Dynorphins; Injections, Spinal; Male; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Spinal Cord Injuries | 1990 |
Clonidine, administered intracerebroventricularly in mice, produces an anti-analgesic effect which may be mediated spinally by dynorphin A (1-17).
Topics: Analgesics; Animals; Clonidine; Dynorphins; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Reaction Time | 1990 |
Kappa opiate receptors inhibit release of oxytocin from the magnocellular system during dehydration.
Topics: Animals; Benzomorphans; Dehydration; Dynorphins; Endorphins; Hypertonic Solutions; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Osmolar Concentration; Oxytocin; Peptide Fragments; Pituitary Gland, Posterior; Protein Precursors; Radioimmunoassay; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Vasopressins | 1990 |
Dynorphin A-(1-17) induces alterations in free fatty acids, excitatory amino acids, and motor function through an opiate-receptor-mediated mechanism.
Topics: Amino Acids; Animals; Dose-Response Relationship, Drug; Drosophila Proteins; Dynorphins; Fatty Acids, Nonesterified; Injections, Spinal; Male; Membrane Proteins; Motor Activity; Naltrexone; Nerve Tissue Proteins; Peptide Fragments; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Spinal Cord; Spinal Cord Injuries; Stereoisomerism | 1990 |
Evidence that the agonist action of dynorphin A(1-8) in the guinea-pig myenteric-plexus may be mediated partly through conversion to [Leu5]enkephalin.
Topics: Animals; Dynorphins; Enkephalin, Leucine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Myenteric Plexus; Naltrexone; Narcotic Antagonists; Peptide Fragments; Receptors, Opioid | 1990 |
Beta-endorphin and dynorphin mimic the circadian immunoenhancing and anti-stress effects of melatonin.
Topics: Adjuvants, Immunologic; Animals; beta-Endorphin; Body Weight; Circadian Rhythm; Dynorphins; Erythrocytes; Female; Hemolytic Plaque Technique; Melatonin; Mice; Mice, Inbred BALB C; Naltrexone; Organ Size; Prednisolone; Restraint, Physical; Stress, Psychological; Thymus Gland | 1989 |
Hypothermia elicited by some prodynorphin-derived peptides: opioid and non-opioid actions.
Topics: Animals; Benzomorphans; Body Temperature; Dynorphins; Endorphins; Hypothermia; Kinetics; Male; Motor Activity; Naloxone; Naltrexone; Peptide Fragments; Rats; Rats, Inbred Strains; Receptors, Opioid | 1989 |
Dynorphin A-induced rat hindlimb paralysis and spinal cord injury are not altered by the kappa opioid antagonist nor-binaltorphimine.
Topics: Animals; Atrophy; Dynorphins; Hindlimb; Ischemia; Male; Naltrexone; Narcotic Antagonists; Paralysis; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Spinal Cord Diseases | 1989 |
Intracerebroventricular physostigmine-induced analgesia: enhancement by naloxone, beta-funaltrexamine and nor-binaltorphimine and antagonism by dynorphin A (1-17).
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Dynorphins; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Narcotic Antagonists; Physostigmine; Time Factors | 1989 |
Selective inactivation of opioid receptors in rat hippocampus demonstrates that dynorphin-A and -B may act on mu-receptors in the CA1 region.
Topics: Animals; Dynorphins; Endorphins; Hippocampus; In Vitro Techniques; Naltrexone; Rats; Receptors, Opioid; Receptors, Opioid, mu | 1985 |
Treatment of stroke with opiate antagonists--effects of exogenous antagonists and dynorphin 1-13.
Topics: Acute Disease; Animals; Brain Ischemia; Cats; Dynorphins; Enkephalin, Leucine; Male; Naloxone; Naltrexone; Narcotic Antagonists; Peptide Fragments | 1985 |
Non-dopaminergic mechanisms in the turning behavior evoked by intranigral opiates.
Topics: Animals; Dynorphins; Enkephalins; Hydroxydopamines; Male; Medial Forebrain Bundle; Morphine; Movement; Naltrexone; Neural Pathways; Oxidopamine; Rats; Rats, Inbred Strains; Substantia Nigra | 1985 |
Opiate antagonists do not alter neuronal responses to stimulation of opioid-containing pathways in rat hippocampus.
Topics: Animals; Dynorphins; Endorphins; Evoked Potentials; Hippocampus; In Vitro Techniques; Naloxone; Naltrexone; Peptide Fragments; Rats; Synaptic Transmission | 1986 |
[3H]dynorphin A binding and kappa selectivity of prodynorphin peptides in rat, guinea-pig and monkey brain.
Topics: Alkylating Agents; Animals; Benzomorphans; Brain Chemistry; Dynorphins; Guinea Pigs; In Vitro Techniques; Macaca mulatta; Morphine; Naltrexone; Peptides; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stereoisomerism | 1986 |
The role of the mediobasal arcuate hypothalamus in relation to opioid systems in the control of ingestive behaviour in the rat.
Topics: Animals; Arcuate Nucleus of Hypothalamus; Body Weight; Brain Chemistry; Circadian Rhythm; Dexamethasone; Dynorphins; Endorphins; Enkephalin, Methionine; Feeding Behavior; Food Deprivation; Male; Naltrexone; Rats; Rats, Inbred Strains | 1986 |
[Frequency as the cardinal determinant for electroacupuncture analgesia to be reversed by opioid antagonists].
Topics: Acupuncture Therapy; Animals; beta-Endorphin; Dynorphins; Electric Stimulation Therapy; Endorphins; Enkephalins; Naloxone; Naltrexone; Pain; Rats; Sensory Thresholds; Transcutaneous Electric Nerve Stimulation | 1986 |
Binaltorphimine and nor-binaltorphimine, potent and selective kappa-opioid receptor antagonists.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Chemical Phenomena; Chemistry; Cyclazocine; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Male; Mice; Morphine; Naloxone; Naltrexone; Pyrrolidines; Rabbits; Receptors, Opioid; Receptors, Opioid, kappa | 1987 |
Effects of beta-chlornaltrexamine on food intake, body weight and opioid-induced feeding.
Topics: Animals; Body Weight; Dynorphins; Eating; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Male; Naltrexone; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid | 1987 |
An examination of the opiate receptor subtypes labeled by [3H]cycloFOXY: an opiate antagonist suitable for positron emission tomography.
Topics: Animals; Autoradiography; Brain; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Naloxone; Naltrexone; Peptide Fragments; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Synaptic Membranes; Tomography, Emission-Computed | 1988 |
Estimated membrane structure and receptor subtype selection of an opioid alkaloid-peptide hybrid.
Topics: Animals; Brain; Cell Membrane; Dynorphins; Guinea Pigs; Kinetics; Naltrexone; Peptide Fragments; Receptors, Opioid; Substrate Specificity | 1988 |
Opioid peptides inhibit intestinal transit in the rat by a central mechanism.
Topics: Animals; beta-Endorphin; Central Nervous System; Diarrhea; Dynorphins; Endorphins; Female; Gastrointestinal Motility; Intestine, Small; Naloxone; Naltrexone; Rats; Rats, Inbred Strains | 1982 |
Application of an irreversible opiate antagonist (beta-FNA, beta-funal-trexamine) to demonstrate dynorphin selectivity for K-opioid sites.
Topics: Animals; Binding, Competitive; Dose-Response Relationship, Drug; Dynorphins; Electric Stimulation; Endorphins; Guinea Pigs; Morphine Derivatives; Muscle, Smooth; Naloxone; Naltrexone; Receptors, Opioid; Time Factors | 1982 |
Preparation of brain membranes containing a single type of opioid receptor highly selective for dynorphin.
Topics: Animals; Brain Chemistry; Cell Membrane; Dynorphins; Endorphins; Guinea Pigs; Ligands; Naloxone; Naltrexone; Receptors, Opioid | 1982 |
Comparison of dynorphin-selective Kappa receptors in mouse vas deferens and guinea pig ileum. Spare receptor fraction as a determinant of potency.
Topics: Animals; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Guinea Pigs; Ileum; Male; Mice; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Receptors, Opioid; Receptors, Opioid, kappa; Structure-Activity Relationship; Vas Deferens | 1983 |
Evidence for a role of the ventro-medial posterior hypothalamus in nociceptive processes in the rat.
Topics: Animals; beta-Endorphin; Dynorphins; Electroshock; Endorphins; Enkephalin, Methionine; Hypothalamus; Hypothalamus, Posterior; Male; Morphine; Naltrexone; Nociceptors; Pain; Protein Precursors; Rats; Rats, Inbred Strains; Stereotaxic Techniques | 1983 |
Opioid receptor selectivity of dynorphin gene products.
Topics: Animals; Dynorphins; Endorphins; Enkephalin, Leucine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Naloxone; Naltrexone; Peptide Fragments; Protein Precursors; Receptors, Opioid | 1984 |
Opioid peptides and seizures in the spontaneously epileptic Mongolian gerbil.
Topics: Animals; beta-Endorphin; Cerebral Cortex; Dynorphins; Endorphins; Enkephalin, Methionine; Epilepsy; Gerbillinae; Morphine; Naltrexone; Narcotics; Seizures | 1983 |
Receptor preference of dynorphin A fragments in the mouse vas deferens determined by different techniques.
Topics: Animals; Drug Tolerance; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Fentanyl; Male; Mice; Naloxone; Naltrexone; Peptide Fragments; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vas Deferens | 1984 |
Which opioid receptor mechanism modulates feeding?
Topics: Animals; Azocines; Diprenorphine; Dynorphins; Endorphins; Feeding Behavior; Humans; Mice; Naloxone; Naltrexone; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, sigma | 1984 |
Demonstration of a specific dynorphin receptor in guinea pig ileum myenteric plexus.
Topics: Animals; Binding, Competitive; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalins; Guinea Pigs; Ileum; Kinetics; Muscle Contraction; Myenteric Plexus; Naltrexone; Narcotic Antagonists; Narcotics; Nitrogen Mustard Compounds; Peptide Fragments; Receptors, Opioid | 1981 |
Effects of dynorphin A-(1-13) on carbon monoxide-induced delayed amnesia in mice studied in a step-down type passive avoidance task.
Topics: Amnesia; Animals; Avoidance Learning; Carbon Monoxide; Dynorphins; Male; Memory; Mice; Mice, Inbred Strains; Naltrexone; Peptide Fragments; Reaction Time; Receptors, Opioid, kappa; Retention, Psychology | 1995 |
Opioids and nitric oxide contribute to hypoxia-induced pial arterial vasodilation in newborn pigs.
Topics: Amino Acid Oxidoreductases; Analysis of Variance; Animals; Animals, Newborn; Arginine; Arterioles; Cerebral Arteries; Cyclic GMP; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Female; Hypoxia; Male; Muscle, Smooth, Vascular; Naltrexone; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Nitroprusside; Receptors, Opioid, kappa; Receptors, Opioid, mu; Swine; Vasodilation | 1995 |
The opioid peptide dynorphin directly blocks NMDA receptor channels in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Dynorphins; In Vitro Techniques; Ion Channels; Naloxone; Naltrexone; Neurons; Patch-Clamp Techniques; Pyrrolidines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa; Structure-Activity Relationship; Trigeminal Nerve | 1995 |
Comparative study of the analgesic and paralytic effects induced by intrathecal dynorphin a in rats.
Topics: Analgesics; Animals; Dynorphins; Injections, Spinal; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Pain Threshold; Paralysis; Psychomotor Performance; Rats; Rats, Wistar; Reaction Time; Spinal Cord; Vocalization, Animal | 1995 |
L-type calcium channels mediate dynorphin neuropeptide release from dendrites but not axons of hippocampal granule cells.
Topics: Animals; Axons; Calcium Channel Blockers; Calcium Channels; Dendrites; Dynorphins; Guinea Pigs; Hippocampus; Isradipine; Long-Term Potentiation; Naltrexone; Nifedipine; omega-Conotoxin GVIA; Peptides; Receptors, Opioid, kappa | 1995 |
kappa-Opioid receptor activates an inwardly rectifying K+ channel by a G protein-linked mechanism: coexpression in Xenopus oocytes.
Topics: Animals; Benzeneacetamides; Cloning, Molecular; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Gene Expression; GTP-Binding Proteins; In Vitro Techniques; Mice; Naloxone; Naltrexone; Oocytes; Pertussis Toxin; Potassium Channels; Pyrrolidines; Receptors, Opioid, kappa; RNA, Complementary; Virulence Factors, Bordetella; Xenopus | 1995 |
Delta-opioid receptor agonists inhibit neuromuscular transmission in human colon.
Topics: Analgesics; Analgesics, Opioid; Colon; Dynorphins; Electric Stimulation; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Gastrointestinal Motility; Humans; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Neuromuscular Junction; Peptide Fragments; Receptors, Opioid, delta; Synaptic Transmission | 1994 |
Influence of hypertension development on rat tail artery responses to opioid peptides.
Topics: Age Factors; Animals; Dose-Response Relationship, Drug; Dynorphins; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Hypertension; In Vitro Techniques; Male; Naltrexone; Narcotic Antagonists; Phenylephrine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; Receptors, Opioid; Tail; Vasoconstriction | 1995 |
kappa-Opioid receptors also increase potassium conductance.
Topics: Animals; Benzeneacetamides; Dynorphins; Electric Conductivity; Guinea Pigs; In Vitro Techniques; Ion Channel Gating; Male; Membrane Potentials; Naltrexone; Potassium Channels; Pyrrolidines; Receptors, Opioid, kappa; Trigeminal Nuclei | 1993 |
Inhibiting a spinal dynorphin A component enhances intrathecal morphine antinociception in mice.
Topics: Analgesics; Animals; Cerebral Ventricles; Dynorphins; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Spine | 1993 |
Dynorphin A(1-17) mediates midazolam antagonism of morphine antinociception in mice.
Topics: Analgesics; Animals; Clonidine; Dose-Response Relationship, Drug; Dynorphins; GABA Antagonists; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Midazolam; Morphine; Naloxone; Naltrexone; Pain Measurement; Reaction Time; Spinal Cord | 1993 |
The effect of central blockade of kappa-opioid receptors on neuropeptide Y-induced feeding in the rat.
Topics: Animals; Cerebral Ventricles; Drug Administration Schedule; Dynorphins; Feeding Behavior; Injections, Intraventricular; Male; Naltrexone; Neuropeptide Y; Rats; Rats, Wistar; Receptors, Opioid, kappa | 1993 |
Blockade of morphine reward through the activation of kappa-opioid receptors in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; 3,4-Dihydroxyphenylacetic Acid; Analgesics; Animals; Apomorphine; Conditioning, Operant; Dopamine; Dynorphins; Homovanillic Acid; Injections, Subcutaneous; Limbic System; Male; Mice; Mice, Inbred Strains; Morphine; Motivation; Naltrexone; Peptide Fragments; Prosencephalon; Pyrrolidines; Receptors, Opioid, kappa; Reward | 1993 |
Neurochemical evidence that estrogen-induced suppression of kappa-opioid-receptor-mediated regulation of tuberoinfundibular dopaminergic neurons is prolactin-independent.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Brain Chemistry; Dopamine; Dynorphins; Estrogens; Female; Hydrazines; Hypothalamic Hormones; Injections, Intraventricular; Median Eminence; Naltrexone; Nerve Endings; Neurons; Ovariectomy; Peptide Fragments; Prolactin; Rats; Receptors, Opioid, kappa | 1994 |
Cardiovascular effects of microinjection of dynorphin-A(1-8) into the hippocampus in conscious, spontaneously hypertensive and normotensive Wistar-Kyoto rats.
Topics: Animals; Blood Pressure; Cardiovascular System; Dose-Response Relationship, Drug; Dynorphins; Hippocampus; Hypertension; Male; Microinjections; Naltrexone; Peptide Fragments; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 1994 |
Central administration of the endopeptidase 24.15 inhibitor cFP-AAF-pAB suggests dynorphin as the endogenous ligand underlying behavioral effects of milk in the fetal rat.
Topics: Amino Acid Sequence; Animals; Behavior, Animal; Cisterna Magna; Dynorphins; Female; Fetus; Injections; Ligands; Metalloendopeptidases; Milk; Molecular Sequence Data; Naltrexone; Narcotic Antagonists; Oligopeptides; Physical Stimulation; Pregnancy; Rats; Rats, Sprague-Dawley; Somatostatin | 1994 |
Electrophysiological studies on the spinal roles of endogenous opioids in carrageenan inflammation.
Topics: Analgesics; Animals; Carrageenan; Dipeptides; Dynorphins; Electrophysiology; Endorphins; Inflammation; Injections, Spinal; Male; Microelectrodes; Naltrexone; Nerve Fibers; Neurons; Nociceptors; Rats; Rats, Sprague-Dawley; Spinal Cord; Synaptic Transmission | 1994 |
Comparative effects of intrahippocampal injection of dynorphin A(1-8), dynorphin A(1-13), dynorphin A(1-17), U-50,488H, and dynorphin B on blood pressure and heart rate in spontaneously hypertensive and normotensive Wistar-Kyoto rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Sequence; Animals; Antihypertensive Agents; Blood Pressure; Dynorphins; Heart Rate; Hippocampus; Hypertension; Male; Molecular Sequence Data; Naltrexone; Peptide Fragments; Pyrrolidines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Reference Values | 1994 |
Cardiovascular responses to intra-hippocampal dynorphin A-(1-8) in spontaneously hypertensive rats.
Topics: Aging; Amino Acid Sequence; Animals; Blood Pressure; Dose-Response Relationship, Drug; Dynorphins; Heart Rate; Hemodynamics; Hippocampus; Male; Microinjections; Molecular Sequence Data; Naltrexone; Peptide Fragments; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; Species Specificity | 1994 |
Kappa opioids inhibit induction of long-term potentiation in the dentate gyrus of the guinea pig hippocampus.
Topics: Animals; Benzeneacetamides; Dynorphins; Electric Stimulation; Guinea Pigs; Hippocampus; Long-Term Potentiation; Male; Naloxone; Naltrexone; Pyrrolidines; Receptors, Opioid, kappa; Synaptic Transmission | 1994 |
Pharmacological characterization of dynorphin A (1-17)-induced effects on spinal cord-evoked potentials.
Topics: Animals; Drug Interactions; Dynorphins; Evoked Potentials; Ganglia, Spinal; Male; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Spinal Cord | 1994 |
Mu- and kappa-opioid receptors selectively reduce the same transient components of high-threshold calcium current in rat dorsal root ganglion sensory neurons.
Topics: Analgesics; Animals; Benzeneacetamides; Calcium; Calcium Channels; Dynorphins; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Evoked Potentials; Ganglia, Spinal; In Vitro Techniques; Naloxone; Naltrexone; Narcotic Antagonists; Neurons, Afferent; Pyrrolidines; Rats; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reference Values; Sensitivity and Specificity | 1994 |
Participation of opioid receptor types on post-tetanic twitch inhibition in isolated guinea-pig ileal longitudinal muscle.
Topics: Amino Acid Sequence; Animals; Dynorphins; Electric Stimulation; Enkephalin, Leucine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Molecular Sequence Data; Morphine; Muscle Contraction; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Narcotics; Peptide Fragments; Receptors, Opioid | 1994 |
Opioid peptides selective for receptor types modulate cocaine-induced behavioral responses in mice.
Topics: Animals; Behavior, Animal; Cocaine; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Naltrexone; Opioid Peptides | 1994 |
Differential binding domains of peptide and non-peptide ligands in the cloned rat kappa opioid receptor.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Sequence; Animals; Base Sequence; Benzeneacetamides; Binding Sites; Binding, Competitive; Cell Line; Chlorocebus aethiops; Cloning, Molecular; Diprenorphine; DNA Primers; Dynorphins; Endorphins; Kinetics; Ligands; Molecular Sequence Data; Naltrexone; Polymerase Chain Reaction; Protein Conformation; Protein Structure, Secondary; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Fusion Proteins; Transfection | 1994 |
Endogenous dynorphins inhibit excitatory neurotransmission and block LTP induction in the hippocampus.
Topics: Action Potentials; Animals; Benzeneacetamides; Dynorphins; Glutamates; Glutamic Acid; Guinea Pigs; Hippocampus; In Vitro Techniques; Naltrexone; Neural Inhibition; Neurotransmitter Agents; Pyrrolidines; Receptors, Opioid, kappa; Synapses; Time Factors | 1993 |
A role for neuropeptide-Y, dynorphin, and noradrenaline in the central control of food intake after food deprivation.
Topics: Animals; Antibodies, Monoclonal; Dynorphins; Eating; Food Deprivation; Immunization, Passive; Male; Naltrexone; Neuropeptide Y; Norepinephrine; Phentolamine; Rats; Rats, Wistar; Receptors, Opioid, kappa | 1993 |
Endogenous dynorphin modulates calcium-mediated antinociception in mice.
Topics: Animals; Calcium; Dynorphins; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Nociceptors; Peptide Fragments; Phenobarbital | 1993 |
Opioid antagonists: indirect antagonism of morphine analgesia by spinal dynorphin A.
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Dynorphins; Injections, Intraventricular; Injections, Spinal; Levallorphan; Male; Mice; Mice, Inbred ICR; Morphine; Nalbuphine; Naltrexone; Nociceptors; Spinal Cord | 1993 |
Dynorphin A-(1-13) markedly improves scopolamine-induced impairment of spontaneous alternation performance in mice.
Topics: Analysis of Variance; Animals; Drug Interactions; Dynorphins; Male; Memory; Mice; Naltrexone; Peptide Fragments; Psychomotor Performance; Receptors, Opioid, kappa; Scopolamine | 1993 |
The kappa opioid receptor expressed on the mouse R1.1 thymoma cell line is coupled to adenylyl cyclase through a pertussis toxin-sensitive guanine nucleotide-binding regulatory protein.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Analgesics; Animals; Cell Membrane; Cyclic AMP; Dynorphins; GTP-Binding Proteins; Mice; Naltrexone; Pertussis Toxin; Pyrrolidines; Receptors, Opioid, kappa; Sensitivity and Specificity; Thymoma; Thymus Neoplasms; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1993 |
Regulatory role of enteric kappa opioid receptors in human colonic motility.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Colon, Sigmoid; Dynorphins; Electric Stimulation; Enkephalin, Leucine; Gastrointestinal Motility; Humans; In Vitro Techniques; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid, kappa | 1993 |
[Effects of intrasubarachnoid space injection of anti dynorphin A1-13 serum or nor-BNI on the recovery of spinal cord injury in rats].
Topics: Animals; Dynorphins; Immune Sera; In Vitro Techniques; Injections, Spinal; Male; Naltrexone; Narcotic Antagonists; Peptide Fragments; Rats; Receptors, Opioid, kappa; Spinal Cord Injuries | 1995 |
Discriminative stimulus effects on enadoline in pigeons.
Topics: Animals; Benzofurans; Butorphanol; Columbidae; Discrimination Learning; Dose-Response Relationship, Drug; Dynorphins; Nalbuphine; Naltrexone; Pyrrolidines; Receptors, Opioid, kappa | 1996 |
Intrastriatal injection of opioid receptor agonists inhibits apomorphine-induced behavior in 6-hydroxydopamine-treated mice.
Topics: Animals; Apomorphine; Behavior, Animal; Corpus Striatum; Dopamine; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Naltrexone; Oxidopamine; Peptide Fragments; Receptors, Opioid | 1995 |
[Receptor mechanism of dynorphin A in rat secondary spinal cord injuries].
Topics: Animals; Dynorphins; Immune Sera; Injections, Spinal; Male; Naltrexone; Peptide Fragments; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Spinal Cord Injuries | 1996 |
A role for central cannabinoid and opioid systems in peripheral delta 9-tetrahydrocannabinol-induced analgesia in mice.
Topics: Analgesics; Animals; Central Nervous System; Dose-Response Relationship, Drug; Dronabinol; Dynorphins; Injections, Intravenous; Male; Mice; Naltrexone; Narcotic Antagonists; Pain Measurement; Peripheral Nervous System; Piperidines; Pyrazoles; Reaction Time; Receptors, Cannabinoid; Receptors, Drug; Receptors, Opioid; Rimonabant | 1996 |
Involvement of the opioid system in the anxiolytic effect of diazepam in mice.
Topics: Analgesics, Non-Narcotic; Animals; Anti-Anxiety Agents; Anticonvulsants; Body Temperature; Conflict, Psychological; Diazepam; Drug Interactions; Dynorphins; Male; Mice; Mice, Inbred Strains; Motor Activity; Naltrexone; Narcotic Antagonists; Peptide Fragments; Receptors, Opioid; Receptors, Opioid, kappa | 1996 |
Pronociceptive effects of the neuropeptide, nociceptin, in the land snail, Cepaea nemoralis.
Topics: Amino Acid Sequence; Animals; Dose-Response Relationship, Drug; Dynorphins; Hot Temperature; Molecular Sequence Data; Naltrexone; Narcotic Antagonists; Nociceptin; Nociceptors; Opioid Peptides; Pain Measurement; Receptors, Opioid; Receptors, Opioid, kappa; Snails; Time Factors | 1996 |
Replacement of Gln280 by His in TM6 of the human ORL1 receptor increases affinity but reduces intrinsic activity of opioids.
Topics: Adenylyl Cyclase Inhibitors; Animals; Binding, Competitive; Cell Membrane; CHO Cells; Cricetinae; Diprenorphine; Dynorphins; Etorphine; Fentanyl; Glutamine; Histamine; Humans; Kinetics; Ligands; Naltrexone; Narcotic Antagonists; Narcotics; Nociceptin; Nociceptin Receptor; Opioid Peptides; Receptors, Opioid | 1996 |
Evidence that D2 receptor-mediated activation of hypothalamic tuberoinfundibular dopaminergic neurons in the male rat occurs via inhibition of tonically active afferent dynorphinergic neurons.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; 3,4-Dihydroxyphenylacetic Acid; Afferent Pathways; Analgesics; Animals; Cerebral Ventricles; Dihydroxyphenylalanine; Dopa Decarboxylase; Dopamine; Dopamine Agonists; Dynorphins; Hypothalamus; Hypothalamus, Middle; Injections, Intraperitoneal; Injections, Intraventricular; Limbic System; Male; Median Eminence; Naltrexone; Narcotic Antagonists; Neurons; Nucleus Accumbens; Prolactin; Pyrrolidines; Quinolines; Rats; Receptors, Dopamine D2; Receptors, Opioid, kappa | 1996 |
Systemic administration of dynorphin A-(1-13) markedly improves cycloheximide-induced amnesia in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amnesia; Analgesics; Animals; Avoidance Learning; Cycloheximide; Dynorphins; Injections, Intraventricular; Male; Memory; Mice; Naltrexone; Narcotic Antagonists; Protein Synthesis Inhibitors; Pyrrolidines; Quaternary Ammonium Compounds; Receptors, Opioid, kappa | 1996 |
Opioid receptor agonists activate pertussis toxin-sensitive G proteins and inhibit adenylyl cyclase in canine cardiac sarcolemma.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Analgesics; Analysis of Variance; Animals; Diprenorphine; Dogs; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; GTP Phosphohydrolases; GTP-Binding Proteins; Myocardium; Naltrexone; Narcotic Antagonists; Pertussis Toxin; Sarcolemma; Virulence Factors, Bordetella | 1996 |
Moving from the orphanin FQ receptor to an opioid receptor using four point mutations.
Topics: Analgesics; Animals; Benzomorphans; Dynorphins; Models, Molecular; Naltrexone; Narcotic Antagonists; Nociceptin Receptor; Point Mutation; Rats; Receptors, Opioid | 1996 |
Melatonin-induced T-helper cell hematopoietic cytokines resembling both interleukin-4 and dynorphin.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Chromatography, Gel; Chromatography, High Pressure Liquid; Drug Combinations; Dynorphins; Electrophoresis, Polyacrylamide Gel; Female; Hematopoietic System; Immunoblotting; Interleukin-4; Melatonin; Mice; Mice, Inbred C57BL; Molecular Weight; Naltrexone; Narcotic Antagonists; T-Lymphocytes, Helper-Inducer | 1996 |
Effects of dynorphin A (1-13) on carbon monoxide-induced delayed amnesia in mice.
Topics: Amnesia; Animals; Carbon Monoxide Poisoning; Dizocilpine Maleate; Dynorphins; Excitatory Amino Acid Antagonists; Injections, Intraventricular; Male; Maze Learning; Mecamylamine; Mice; Mice, Inbred Strains; Naltrexone; Narcotic Antagonists; Narcotics; Nicotinic Antagonists; Peptide Fragments; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa | 1997 |
Inhibition of lipopolysaccharide-induced nitric oxide and cytokine production by ultralow concentrations of dynorphins in mixed glia cultures.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cells, Cultured; Dynorphins; Lipopolysaccharides; Mice; Naltrexone; Neuroglia; Nitric Oxide; Peptide Fragments; Pyrrolidines; Tumor Necrosis Factor-alpha | 1997 |
Effects of the kappa-opioid dynorphin A(1-13) on learning and memory in mice.
Topics: Analgesics, Opioid; Animals; Dynorphins; Injections, Intraventricular; Learning; Learning Disabilities; Male; Memory; Memory Disorders; Memory, Short-Term; Mice; Mice, Inbred Strains; Muscarinic Antagonists; Naltrexone; Narcotic Antagonists; Peptide Fragments; Pirenzepine; Receptors, Opioid, kappa; Scopolamine | 1997 |
Dynorphin A-mediated reduction in multiple calcium currents involves a G(o) alpha-subtype G protein in rat primary afferent neurons.
Topics: Animals; Blotting, Western; Calcitonin Gene-Related Peptide; Calcium Channel Blockers; Calcium Channels; Dynorphins; Electric Stimulation; Ganglia, Spinal; GTP-Binding Proteins; Immunohistochemistry; Membrane Potentials; Naltrexone; Narcotic Antagonists; Neurons, Afferent; Patch-Clamp Techniques; Rats; Receptors, Opioid, kappa | 1997 |
Dynorphin-(1-8) inhibits the release of substance P-like immunoreactivity in the spinal cord of rats following a noxious mechanical stimulus.
Topics: Animals; Decerebrate State; Dynorphins; Hindlimb; Male; Naltrexone; Pain; Peptide Fragments; Physical Stimulation; Radioimmunoassay; Rats; Rats, Wistar; Receptors, Opioid, kappa; Spinal Cord; Substance P | 1997 |
Opioids in the nucleus of the solitary tract are involved in feeding in the rat.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Feeding Behavior; Male; Microinjections; Naltrexone; Rats; Rats, Sprague-Dawley; Solitary Nucleus | 1997 |
Characterization of anandamide-induced tolerance: comparison to delta 9-THC-induced interactions with dynorphinergic systems.
Topics: Analgesics; Animals; Arachidonic Acids; Cannabinoids; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Drug Tolerance; Dynorphins; Endocannabinoids; Injections, Intraperitoneal; Injections, Spinal; Mice; Naltrexone; Narcotic Antagonists; Pain Measurement; Polyunsaturated Alkamides; Receptors, Cannabinoid; Receptors, Drug | 1997 |
Participation of central kappa-opioid receptor in arrhythmogenesis.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Arrhythmias, Cardiac; Dynorphins; Epinephrine; Hexamethonium; Male; Naloxone; Naltrexone; Narcotic Antagonists; Peptide Fragments; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, kappa | 1997 |
[Central K1-opiate receptors and mechanisms of arrhythmogenesis].
Topics: Animals; Arrhythmias, Cardiac; Blood-Brain Barrier; Brain; Dynorphins; Ganglionic Blockers; Heart; Hexamethonium; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Parasympathetic Nervous System; Rats; Rats, Wistar; Receptors, Opioid, kappa | 1997 |
Opioid receptor-mediated inhibition of omega-conotoxin GVIA-sensitive calcium channel currents in rat intracardiac neurons.
Topics: Acetylcholine; Animals; Animals, Newborn; Anti-Arrhythmia Agents; Benzomorphans; Calcium; Calcium Channels; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Heart Conduction System; Ion Channel Gating; Ion Transport; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; omega-Conotoxin GVIA; Parasympathetic Nervous System; Patch-Clamp Techniques; Peptides; Pertussis Toxin; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Virulence Factors, Bordetella | 1998 |
Supraspinal flumazenil inhibits the antianalgesic action of spinal dynorphin A (1-17).
Topics: Analgesia; Analgesics; Animals; Clonidine; Dose-Response Relationship, Drug; Drug Interactions; Dynorphins; Flumazenil; GABA Agonists; GABA-A Receptor Agonists; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Naltrexone; Physostigmine | 1998 |
Hippocampal dynorphin B injections impair spatial learning in rats: a kappa-opioid receptor-mediated effect.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Hippocampus; Male; Maze Learning; Microinjections; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Spatial Behavior | 1998 |
Dynorphin uses a non-opioid mechanism to potentiate N-methyl-D-aspartate currents in single rat periaqueductal gray neurons.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Action Potentials; Analgesics, Non-Narcotic; Animals; Drug Synergism; Dynorphins; N-Methylaspartate; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Patch-Clamp Techniques; Peptide Fragments; Periaqueductal Gray; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa | 1998 |
Role of opioids in hypoxic pial artery dilation is stimulus duration dependent.
Topics: Animals; Arteries; Dynorphins; Enkephalin, Methionine; Female; Hypoxia, Brain; Male; Naltrexone; Narcotic Antagonists; Opioid Peptides; Pia Mater; Swine; Vasodilation | 1998 |
Inhibition of the neuronal nicotinic receptor-mediated current by kappa opioid receptor agonists in PC12 cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Dynorphins; Electric Conductivity; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Naltrexone; Narcotic Antagonists; Neurons; Nicotinic Antagonists; PC12 Cells; Rats; Receptors, Nicotinic; Receptors, Opioid, kappa | 1998 |
kappa-opioid regulation of neuronal activity in the rat supraoptic nucleus in vivo.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Cells, Cultured; Dendrites; Down-Regulation; Dynorphins; Electrophysiology; Female; Injections, Intravenous; Membrane Potentials; Microdialysis; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Oxytocin; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Supraoptic Nucleus; Vasopressins | 1998 |
5-HT4 receptor agonists and delta-opioid receptor antagonists act synergistically to stimulate colonic propulsion.
Topics: Animals; Benzeneacetamides; Colon; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Guinea Pigs; In Vitro Techniques; Male; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Peptide Fragments; Peristalsis; Pyrrolidines; Receptors, Opioid, delta; Receptors, Serotonin; Receptors, Serotonin, 5-HT4; Serotonin Receptor Agonists; Somatostatin | 1998 |
Regulation of cocaine reward by CREB.
Topics: Animals; Cocaine; Conditioning, Psychological; Cyclic AMP Response Element-Binding Protein; Dose-Response Relationship, Drug; Dynorphins; Gene Expression; Gene Expression Regulation; Gene Transfer Techniques; Genetic Vectors; Naltrexone; Narcotic Antagonists; Neurons; Nucleus Accumbens; Point Mutation; Rats; Receptors, Opioid, kappa; Reward; RNA, Messenger; Simplexvirus | 1998 |
Opioid peptide pharmacology and immunocytochemistry in an animal model of self-sustaining status epilepticus.
Topics: Action Potentials; Analgesics; Analgesics, Opioid; Animals; Disease Models, Animal; Dynorphins; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Immunohistochemistry; Male; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Opioid Peptides; Peptide Fragments; Perforant Pathway; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Status Epilepticus | 1999 |
Dynorphin A increases substance P release from trigeminal primary afferent C-fibers.
Topics: Animals; Animals, Newborn; Capsaicin; Dizocilpine Maleate; Dynorphins; Enkephalin, Leucine; Excitatory Amino Acid Antagonists; In Vitro Techniques; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nerve Fibers; Neurons, Afferent; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Substance P; Trigeminal Nuclei | 1999 |
Activation of peripheral kappa opioid receptors inhibits capsaicin-induced thermal nociception in rhesus monkeys.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Azocines; Benzomorphans; Capsaicin; Dynorphins; Female; Hot Temperature; Ligands; Macaca mulatta; Male; Naltrexone; Narcotic Antagonists; Pain Measurement; Peptide Fragments; Receptors, Opioid, kappa | 1999 |
Analgesia-producing mechanism of processed Aconiti tuber: role of dynorphin, an endogenous kappa-opioid ligand, in the rodent spinal cord.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Administration, Topical; Analgesics; Animals; Arcuate Nucleus of Hypothalamus; Cold Temperature; Dexamethasone; Dopamine Antagonists; Drugs, Chinese Herbal; Dynorphins; Glucocorticoids; Hypothalamus; Immune Sera; Ligands; Male; Mice; Naltrexone; Narcotic Antagonists; Nociceptors; Pain; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Salicylamides; Spinal Cord; Sulpiride | 1999 |
Ligands for opioid and sigma-receptors improve cardiac electrical stability in rat models of post-infarction cardiosclerosis and stress.
Topics: Animals; Anti-Arrhythmia Agents; beta-Endorphin; Disease Models, Animal; Dynorphins; Enkephalin, Leucine-2-Alanine; Heart; Immobilization; Ligands; Morphine; Myocardial Infarction; Myocardium; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Piperidines; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, delta; Stress, Physiological; Ventricular Fibrillation | 1999 |
Modulation of neurotransmitter release in the basal ganglia of the rat brain by dynorphin peptides.
Topics: Animals; Basal Ganglia; Dopamine; Dynorphins; Male; Microinjections; Naltrexone; Narcotic Antagonists; Neostriatum; Perfusion; Rats; Rats, Sprague-Dawley; Substantia Nigra | 1999 |
Cannabinoid modulation of dynorphin A: correlation to cannabinoid-induced antinociception.
Topics: Analgesics; Animals; Cannabinoids; Cyclohexanols; Dimethyl Sulfoxide; Dronabinol; Dynorphins; Injections, Spinal; Male; Naltrexone; Narcotic Antagonists; Nociceptors; Pain; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant | 1999 |
Hematopoietic effect of melatonin involvement of type 1 kappa-opioid receptor on bone marrow macrophages and interleukin-1.
Topics: Animals; Antibodies, Monoclonal; Bone Marrow Cells; Cells, Cultured; Colony-Forming Units Assay; Dynorphins; Female; Granulocyte-Macrophage Colony-Stimulating Factor; Granulocytes; Hematopoiesis; Immunohistochemistry; Interleukin-1; Macrophages; Melatonin; Mice; Mice, Inbred C57BL; Naltrexone; Narcotic Antagonists; Oligodeoxyribonucleotides, Antisense; Receptors, Opioid, kappa | 1999 |
Effects of E-2078, a stable dynorphin A(1-8) analog, on sedation and serum prolactin levels in rhesus monkeys.
Topics: Animals; Azocines; Dose-Response Relationship, Drug; Dynorphins; Female; Hypnotics and Sedatives; Injections, Subcutaneous; Macaca mulatta; Male; Motor Activity; Muscle Relaxation; Naltrexone; Narcotic Antagonists; Peptide Fragments; Prolactin; Pyrrolidines; Receptors, Opioid, kappa; Time Factors | 1999 |
Dynorphin A (1-13) neurotoxicity in vitro: opioid and non-opioid mechanisms in mouse spinal cord neurons.
Topics: Analgesics, Opioid; Animals; Calcium; Cell Survival; Dizocilpine Maleate; Dynorphins; Embryo, Mammalian; Kynurenic Acid; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Neurotoxins; Peptide Fragments; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Valine | 1999 |
Dynorphin A enhances mitogen-induced proliferative response and interleukin-2 production of rat splenocytes.
Topics: Analgesics, Opioid; Animals; Cells, Cultured; Concanavalin A; Dynorphins; Interleukin-2; Lymphocyte Activation; Lymphocytes; Male; Naloxone; Naltrexone; Narcotic Antagonists; Peptide Fragments; Rats; Rats, Sprague-Dawley; Spleen | 1999 |
Dynorphin A-(1-13) and (2-13) improve beta-amyloid peptide-induced amnesia in mice.
Topics: Amnesia; Amyloid beta-Peptides; Animals; Avoidance Learning; Behavior, Animal; Dynorphins; Male; Maze Learning; Mice; Naltrexone; Narcotic Antagonists; Narcotics; Peptide Fragments; Reaction Time | 2000 |
Identification of the opioid receptors involved in passive-avoidance learning in the day-old chick during the second wave of neuronal activity.
Topics: Age Factors; Amnesia; Analgesics, Opioid; Animals; Anisomycin; Avoidance Learning; Brain Chemistry; Chickens; Chloramphenicol; Conditioning, Psychological; Dynorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Female; Male; Memory; Naltrexone; Narcotic Antagonists; Neurons; Nociceptin; Oligopeptides; Opioid Peptides; Protein Synthesis Inhibitors; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vasodilator Agents | 2000 |
Chronic l-alpha-acetylmethadol (LAAM) in rhesus monkeys: tolerance and cross-tolerance to the antinociceptive, ventilatory, and rate-decreasing effects of opioids.
Topics: Analgesics, Opioid; Animals; Drug Tolerance; Dynorphins; Female; Ketamine; Macaca mulatta; Male; Methadyl Acetate; Nalbuphine; Naltrexone; Narcotics; Respiration | 2000 |
Altered opioid-mediated control of the spinal release of dynorphin and met-enkephalin in polyarthritic rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia; Animals; Arthritis; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Iodine Radioisotopes; Ligands; Male; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 2000 |
Antinociceptive effect produced by intracerebroventricularly administered dynorphin A is potentiated by p-hydroxymercuribenzoate or phosphoramidon in the mouse formalin test.
Topics: Animals; Brain; Cell Extracts; Drug Interactions; Dynorphins; Glycopeptides; Hydroxymercuribenzoates; Injections, Intraventricular; Mice; Naltrexone; Narcotic Antagonists; Nociceptors; Pain; Pain Measurement; Protease Inhibitors; Rats | 2001 |
From models to molecules: opioid receptor dimers, bivalent ligands, and selective opioid receptor probes.
Topics: Amino Acid Sequence; Binding Sites; Dimerization; Dynorphins; Ligands; Models, Molecular; Molecular Sequence Data; Naltrexone; Narcotic Antagonists; Protein Structure, Secondary; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Structure-Activity Relationship | 2001 |
Alterations in central preproenkephalin mRNA expression after chronic free-choice ethanol consumption by fawn-hooded rats.
Topics: Amygdala; Animals; Brain; Dynorphins; Enkephalins; Ethanol; Gene Expression; Male; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Olfactory Pathways; Protein Precursors; Rats; Receptors, Dopamine D1; Receptors, Dopamine D2; RNA, Messenger; Self Administration | 2001 |
Differential antinociceptive effects induced by intrathecally administered endomorphin-1 and endomorphin-2 in the mouse.
Topics: Analgesics; Animals; Benzylidene Compounds; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Methionine; Immune Sera; Injections, Spinal; Injections, Subcutaneous; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain; Pain Measurement; Pain Threshold; Peptide Fragments; Time Factors | 2001 |
Roles of endogenous opioid peptides in modulation of nocifensive response to formalin.
Topics: Animals; Antibodies, Blocking; Dynorphins; Endorphins; Enkephalins; Formaldehyde; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Pain Measurement; Receptors, Opioid; Somatostatin; Spinal Cord | 2002 |
Dynorphin A(1-17)-induced feeding: pharmacological characterization using selective opioid antagonists and antisense probes in rats.
Topics: Animals; Dose-Response Relationship, Drug; Drug Interactions; Dynorphins; Feeding Behavior; Male; Models, Animal; Naltrexone; Narcotic Antagonists; Oligonucleotides, Antisense; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2002 |
The neuropeptide FF analogue, 1DMe, reduces in vivo dynorphin release from the rat spinal cord.
Topics: Animals; Dose-Response Relationship, Drug; Dynorphins; Injections, Spinal; Male; Models, Animal; Naltrexone; Narcotic Antagonists; Oligopeptides; Peptide Fragments; Perfusion; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin; Spinal Cord | 2002 |
Opioid receptor blockade in rat nucleus tractus solitarius alters amygdala dynorphin gene expression.
Topics: Amygdala; Animals; Body Weight; Dynorphins; Eating; Gene Expression; Leptin; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Solitary Nucleus | 2002 |
Blockade of nigral and pallidal opioid receptors suppresses vacuous chewing movements in a rodent model of tardive dyskinesia.
Topics: Animals; Dose-Response Relationship, Drug; Dynorphins; Dyskinesia, Drug-Induced; Fluphenazine; Globus Pallidus; Male; Mastication; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Somatostatin; Substantia Nigra | 2002 |
Expression of functional kappa-opioid receptors on murine dendritic cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Antigen Presentation; Dendritic Cells; Dynorphins; Gene Expression; Histocompatibility Antigens Class II; In Vitro Techniques; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Naltrexone; Narcotic Antagonists; Neuroimmunomodulation; Phenotype; Receptors, Opioid, kappa; RNA, Messenger | 2002 |
Effect of prodynorphin-derived opioid peptides on the ovulatory luteinizing hormone surge in the proestrous rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Brain; Dynorphins; Enkephalins; Female; Luteinizing Hormone; Naltrexone; Ovulation; Peptide Fragments; Proestrus; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa | 2002 |
Lack of the nociceptin receptor does not affect acute or chronic nociception in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Female; Male; Mice; Mice, Knockout; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptin; Nociceptin Receptor; Oligopeptides; Opioid Peptides; Pain; Receptors, Opioid; Time Factors; Vas Deferens | 2002 |
Relationship between NOC/oFQ, dynorphin, and COX-2 activation in impaired NMDA cerebrovasodilation after brain injury.
Topics: Animals; Animals, Newborn; Brain Injuries; Cyclooxygenase 2; Dynorphins; Enzyme Activation; Female; Glutamic Acid; Indomethacin; Isoenzymes; Male; N-Methylaspartate; Naltrexone; Nitrobenzenes; Nociceptin; Opioid Peptides; Pia Mater; Prostaglandin-Endoperoxide Synthases; Sulfonamides; Superoxides; Swine; Vasodilation | 2002 |
Dynorphin-independent spinal cannabinoid antinociception.
Topics: Analgesics; Analgesics, Non-Narcotic; Animals; Benzoxazines; Dose-Response Relationship, Drug; Dronabinol; Dynorphins; Injections, Spinal; Male; Mice; Mice, Knockout; Morpholines; Naltrexone; Naphthalenes; Pain; Pain Measurement; Reference Values; Reproducibility of Results; Sensitivity and Specificity; Single-Blind Method; Species Specificity; Spinal Cord | 2002 |
Inhibition of cAMP response element-binding protein or dynorphin in the nucleus accumbens produces an antidepressant-like effect.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Cyclic AMP Response Element-Binding Protein; Depression; Dynorphins; Enkephalins; Helplessness, Learned; Immunohistochemistry; Male; Mice; Mice, Transgenic; Mutation; Naltrexone; Nucleus Accumbens; Prosencephalon; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa | 2002 |
[Repeated 100 Hz TENS for the treatment of chronic inflammatory pain in rats: optimal parameters and possible neuro-chemical mechanisms].
Topics: Animals; Arthralgia; Arthritis, Experimental; Chronic Disease; Dynorphins; Naltrexone; Pain Threshold; Rats; Substance P; Transcutaneous Electric Nerve Stimulation | 1999 |
Endogenous opioid peptides contribute to antinociceptive potency of intrathecal [Dmt1]DALDA.
Topics: Analgesics, Opioid; Animals; Antibodies, Blocking; Cloning, Molecular; Dynorphins; Endorphins; Enkephalin, Methionine; Guanosine 5'-O-(3-Thiotriphosphate); Hot Temperature; Injections, Intraventricular; Injections, Spinal; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain Measurement; Radioligand Assay; Reaction Time; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2003 |
Identity of the putative delta1-opioid receptor as a delta-kappa heteromer in the mouse spinal cord.
Topics: Animals; Benzylidene Compounds; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Immune Sera; Mice; Naltrexone; Oligopeptides; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin; Spinal Cord | 2003 |
Activation of delta- and kappa-opioid receptors by opioid peptides protects cardiomyocytes via KATP channels.
Topics: Adenosine Triphosphate; Animals; Benzamides; Cardiotonic Agents; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, Methionine; Guanidines; Ischemic Preconditioning, Myocardial; Male; Mitochondria; Morphinans; Myocardial Ischemia; Myocytes, Cardiac; Naltrexone; Narcotic Antagonists; Potassium Channels; Rabbits; Receptors, Opioid, delta; Receptors, Opioid, kappa; Sarcolemma | 2003 |
Involvement of mesolimbic structures in short-term sodium depletion: in situ hybridization and ligand-binding analyses.
Topics: Animals; Autoradiography; Corpus Striatum; Desoxycorticosterone; Diuresis; Dopamine Antagonists; Dopamine Plasma Membrane Transport Proteins; Drinking; Dynorphins; Enkephalins; Furosemide; In Situ Hybridization; Limbic System; Male; Membrane Glycoproteins; Membrane Transport Proteins; Naltrexone; Narcotic Antagonists; Nerve Tissue Proteins; Nucleus Accumbens; Raclopride; Random Allocation; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sodium Chloride; Sodium Chloride, Dietary; Sodium, Dietary; Thirst; Water | 2003 |
Dynorphinergic mechanism mediating endomorphin-2-induced antianalgesia in the mouse spinal cord.
Topics: Analgesics, Opioid; Animals; Antibodies, Blocking; Dizocilpine Maleate; Dose-Response Relationship, Drug; Dynorphins; Excitatory Amino Acid Antagonists; Injections, Spinal; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain Measurement; Reaction Time; Receptors, Opioid; Spinal Cord | 2003 |
Peripheral selectivity and apparent efficacy of dynorphins: comparison to non-peptidic kappa-opioid agonists in rhesus monkeys.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Benzeneacetamides; Blood-Brain Barrier; Discrimination Learning; Dose-Response Relationship, Drug; Dynorphins; Female; Hypothalamus; Injections, Intravenous; Macaca mulatta; Male; Naltrexone; Neurosecretory Systems; Peptide Fragments; Prolactin; Pyrrolidines; Receptors, Opioid, kappa | 2004 |
Opioid-mediated modulation of calcium currents in striatal and pallidal neurons following reserpine treatment: focus on kappa response.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic Uptake Inhibitors; Alkaloids; Analgesics, Non-Narcotic; Analgesics, Opioid; Analysis of Variance; Animals; Benzophenanthridines; Calcium Channel Blockers; Calcium Channels; Cell Size; Cells, Cultured; Corpus Striatum; Dose-Response Relationship, Drug; Drug Interactions; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enzyme Inhibitors; Male; Membrane Potentials; Naltrexone; Narcotic Antagonists; Neural Inhibition; Neurons; omega-Conotoxin GVIA; Patch-Clamp Techniques; Phenanthridines; Rats; Rats, Wistar; Receptors, Opioid, kappa; Reserpine | 2004 |
Differential antinociceptive effects of L-arginine and 3-morpholinosydoimine.
Topics: Analgesics; Animals; Arginine; Dose-Response Relationship, Drug; Dynorphins; Injections, Intraventricular; Male; Mice; Molsidomine; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement | 2003 |
Effects of kappa-opioid receptor ligands on intracranial self-stimulation in rats.
Topics: Animals; Behavior, Animal; Benzeneacetamides; Brain; Dose-Response Relationship, Drug; Drug Interactions; Dynorphins; Electric Stimulation; Electrodes, Implanted; Injections, Intraperitoneal; Ligands; Male; Naltrexone; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reward; Self Stimulation; Time Factors | 2004 |
Differential conditioned place preference responses to endomorphin-1 and endomorphin-2 microinjected into the posterior nucleus accumbens shell and ventral tegmental area in the rat.
Topics: Animals; Conditioning, Psychological; Dynorphins; Male; Microinjections; Naltrexone; Nucleus Accumbens; Oligopeptides; Rats; Receptors, Opioid, kappa; Receptors, Opioid, mu; Serum; Somatostatin; Space Perception; Substantia Nigra; Ventral Tegmental Area | 2004 |
Temporal dissociation of the feedback effects of dendritically co-released peptides on rhythmogenesis in vasopressin cells.
Topics: Action Potentials; Animals; Antidiuretic Hormone Receptor Antagonists; Dendrites; Dynorphins; Feedback, Physiological; Female; Naltrexone; Narcotic Antagonists; Periodicity; Piperidines; Quinolones; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Supraoptic Nucleus; Vasopressins | 2004 |
Effects of chronic administration of PL017 and beta-funaltrexamine hydrochloride on susceptibility of kainic acid-induced seizures in rats.
Topics: Animals; Disease Susceptibility; Dynorphins; Epilepsy; Hippocampus; Kainic Acid; Male; Naltrexone; Peptide Fragments; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 2004 |
Nonopioidergic mechanism mediating morphine-induced antianalgesia in the mouse spinal cord.
Topics: Analgesia; Animals; beta-Endorphin; Dizocilpine Maleate; Drug Interactions; Drug Tolerance; Dynorphins; Enkephalins; Male; Mice; Morphine; Naloxone; Naltrexone; Oligopeptides; Pain; Pain Measurement; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord; Substance P | 2004 |
Relative contribution of endogenous opioids to myocardial ischemic tolerance.
Topics: Animals; Dynorphins; Endorphins; Enkephalin, Methionine; In Vitro Techniques; Ischemic Preconditioning, Myocardial; Naltrexone; Narcotic Antagonists; Rabbits; Receptors, Opioid, delta; Receptors, Opioid, kappa; Recovery of Function; Ventricular Function, Left | 2004 |
The antinociceptive effect of Delta9-tetrahydrocannabinol in the arthritic rat.
Topics: Animals; Arthritis, Experimental; Cannabinoid Receptor Antagonists; Dose-Response Relationship, Drug; Dronabinol; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Freund's Adjuvant; Injections, Intradermal; Injections, Intraperitoneal; Male; Morphine; Mycobacterium; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Opioid; Rimonabant | 2004 |
Direct evidence for the involvement of the mesolimbic kappa-opioid system in the morphine-induced rewarding effect under an inflammatory pain-like state.
Topics: Animals; Brain Chemistry; Conditioning, Operant; Dopamine; Dynorphins; Edema; Foot; Formaldehyde; Inflammation; Limbic System; Male; Microdialysis; Microinjections; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reward | 2005 |
Stress increases dynorphin immunoreactivity in limbic brain regions and dynorphin antagonism produces antidepressant-like effects.
Topics: Animals; Behavior, Animal; Cell Count; Disease Models, Animal; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Escape Reaction; Helplessness, Learned; Immobilization; Immunohistochemistry; Limbic System; Male; Naltrexone; Rats; Rats, Sprague-Dawley; Stress, Physiological | 2004 |
Opioid receptors and acetaminophen (paracetamol).
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Dynorphins; Endorphins; Enkephalins; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2004 |
Chronic pain induces anxiety with concomitant changes in opioidergic function in the amygdala.
Topics: Amygdala; Analgesics, Opioid; Analysis of Variance; Animals; Anxiety; Behavior, Animal; Benzamides; Chronic Disease; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Freund's Adjuvant; Guanosine 5'-O-(3-Thiotriphosphate); Injections, Intraventricular; Male; Maze Learning; Mice; Mice, Inbred C57BL; Naltrexone; Narcotic Antagonists; Narcotics; Pain; Pain Measurement; Piperazines; Protein Binding; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reaction Time; Sciatica; Somatostatin; Sulfur Isotopes; Time Factors; Tranquilizing Agents | 2006 |
Coordinated and spatial upregulation of arc in striatonigral neurons correlates with L-dopa-induced behavioral sensitization in dyskinetic rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic Agents; AIDS-Related Complex; Amphetamine; Analgesics, Non-Narcotic; Animals; Antiparkinson Agents; Behavior, Animal; Carrier Proteins; Central Nervous System Stimulants; Corpus Striatum; Disease Models, Animal; Drug Interactions; Dynorphins; Dyskinesia, Drug-Induced; Functional Laterality; Homer Scaffolding Proteins; Immunohistochemistry; In Situ Hybridization; Levodopa; Male; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Oxidopamine; Protein Precursors; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Stereotyped Behavior; Substantia Nigra; Time Factors; Tyrosine 3-Monooxygenase; Up-Regulation | 2005 |
The dynamic relationship between mu and kappa opioid receptors in body temperature regulation.
Topics: Animals; Body Temperature Regulation; Dose-Response Relationship, Drug; Drug Antagonism; Dynorphins; Injections, Intraventricular; Male; Naltrexone; Narcotic Antagonists; Neurotransmitter Agents; Peptide Fragments; Peptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin | 2005 |
Big dynorphin, a prodynorphin-derived peptide produces NMDA receptor-mediated effects on memory, anxiolytic-like and locomotor behavior in mice.
Topics: Amino Acid Sequence; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Dose-Response Relationship, Drug; Dynorphins; Enkephalins; Hot Temperature; Male; Memory; Mice; Molecular Sequence Data; Motor Activity; Naltrexone; Pain Measurement; Protein Precursors; Reaction Time; Receptors, N-Methyl-D-Aspartate | 2006 |
Involvement of kappa/dynorphin system in WIN 55,212-2 self-administration in mice.
Topics: Animals; Benzoxazines; Cannabinoids; Conditioning, Operant; Dose-Response Relationship, Drug; Dynorphins; Enkephalins; Male; Mice; Mice, Knockout; Morpholines; Naltrexone; Naphthalenes; Protein Precursors; Receptor, Cannabinoid, CB1; Receptors, Opioid, kappa; Self Administration | 2006 |
Dynorphin A (2-13) improves mecamylamine-induced learning impairment accompanied by reversal of reductions in acetylcholine release in rats.
Topics: Acetylcholine; Animals; Dynorphins; Functional Laterality; Hippocampus; Injections, Intraventricular; Learning; Learning Disabilities; Male; Mecamylamine; Microdialysis; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley | 2006 |
Paradoxical effects of prodynorphin gene deletion on basal and cocaine-evoked dopaminergic neurotransmission in the nucleus accumbens.
Topics: Analgesics; Animals; Area Under Curve; Behavior, Animal; Benzeneacetamides; Chromatography, High Pressure Liquid; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Dynorphins; Electrochemistry; Mice; Mice, Inbred C57BL; Mice, Knockout; Microdialysis; Motor Activity; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Pyrrolidines | 2006 |
Downstream regulatory element antagonistic modulator regulates islet prodynorphin expression.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Calcium; Cell Line; Cell Nucleus; DNA; Dynorphins; Electrophoretic Mobility Shift Assay; Enkephalins; Gene Expression Regulation; Glucagon; Glucagon-Secreting Cells; Glucose; Humans; Insulin-Secreting Cells; Islets of Langerhans; Kv Channel-Interacting Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Naltrexone; Protein Binding; Protein Precursors; Receptors, Opioid, kappa; Repressor Proteins | 2006 |
Modulation of systemic and renal haemodynamics by kappa-opioids in conscious lambs.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Aging; Analgesics, Non-Narcotic; Animals; Blood Circulation; Blood Pressure; Dynorphins; Guanidines; Heart Rate; Hemodynamics; Kidney; Naltrexone; Receptors, Opioid, kappa; Regional Blood Flow; Sheep | 2006 |
Kappa-opioid receptor antagonism improves recovery from myocardial stunning in chronically instrumented dogs.
Topics: Animals; beta-Endorphin; Blood Pressure; Coronary Circulation; Dogs; Dynorphins; Epinephrine; Female; Heart Rate; Male; Myocardial Stunning; Naltrexone; Narcotic Antagonists; Norepinephrine; Radioimmunoassay; Receptors, Opioid, kappa; Ventricular Function, Left | 2006 |
Paradoxical hyperalgesia induced by mu-opioid receptor agonist endomorphin-2, but not endomorphin-1, microinjected into the centromedial amygdala of the rat.
Topics: Amygdala; Analgesics, Opioid; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Dynorphins; Excitatory Amino Acid Antagonists; Hyperalgesia; Immune Sera; Male; Microinjections; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain Measurement; Rabbits; Rats; Receptors, Opioid, mu; Time Factors | 2007 |
Pharmacological evidence for a motivational role of kappa-opioid systems in ethanol dependence.
Topics: Administration, Inhalation; Alcoholism; Animals; Central Nervous System Depressants; Conditioning, Operant; Data Interpretation, Statistical; Dynorphins; Ethanol; Injections, Intraventricular; Male; Motivation; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Self Administration; Substance Withdrawal Syndrome | 2008 |
Sexually dimorphic recruitment of spinal opioid analgesic pathways by the spinal application of morphine.
Topics: Animals; Animals, Newborn; Antibodies; Dose-Response Relationship, Drug; Dynorphins; Female; Injections, Spinal; Male; Morphine; Naltrexone; Narcotic Antagonists; Neural Pathways; Orchiectomy; Ovariectomy; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sex Factors; Spinal Cord; Sufentanil; Virilism | 2007 |
Ethanol alters the effect of kappa receptor ligands on dopamine release in the nucleus accumbens.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Central Nervous System Stimulants; Dopamine; Drug Administration Schedule; Drug Interactions; Drug Tolerance; Dynorphins; Ethanol; Male; Naltrexone; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa | 2007 |
Essential role of mu opioid receptor in the regulation of delta opioid receptor-mediated antihyperalgesia.
Topics: Animals; beta-Endorphin; Dose-Response Relationship, Drug; Dynorphins; Enkephalins; Freund's Adjuvant; Hyperalgesia; Inflammation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain Measurement; Protein Precursors; Reaction Time; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin | 2007 |
The dysphoric component of stress is encoded by activation of the dynorphin kappa-opioid system.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Conditioning, Operant; Corticotropin-Releasing Hormone; Dose-Response Relationship, Drug; Drug Interactions; Dynorphins; Enkephalins; Mice; Mice, Inbred C57BL; Mice, Knockout; Naltrexone; Narcotic Antagonists; Odorants; Phosphorylation; Protein Precursors; Receptors, Opioid, kappa; Stress, Physiological; Swimming; Urocortins | 2008 |
Possible involvement of dynorphin A release via mu1-opioid receptor on supraspinal antinociception of endomorphin-2.
Topics: Analgesics; Animals; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Immune Sera; Injections, Intraventricular; Male; Mice; Naloxone; Naltrexone; Oligopeptides; Protein Precursors; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2008 |
Genetic and early environmental contributions to alcohol's aversive and physiological effects.
Topics: Animals; Avoidance Learning; Central Nervous System Depressants; Conditioning, Operant; Data Interpretation, Statistical; Dynorphins; Ethanol; Extinction, Psychological; Female; Hypothermia; Maternal Behavior; Motivation; Naltrexone; Rats; Receptors, Opioid, kappa; Taste | 2008 |
C2 spinal cord stimulation induces dynorphin release from rat T4 spinal cord: potential modulation of myocardial ischemia-sensitive neurons.
Topics: Animals; Brain Stem; Coronary Vessels; Dynorphins; Electric Stimulation; Excitatory Amino Acid Agonists; Ibotenic Acid; Image Processing, Computer-Assisted; Immunohistochemistry; Male; Myocardial Ischemia; Naltrexone; Narcotic Antagonists; Neural Pathways; Neurons; Posterior Horn Cells; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P | 2008 |
Repeated swim stress induces kappa opioid-mediated activation of extracellular signal-regulated kinase 1/2.
Topics: Analgesics, Opioid; Animals; Caudate Nucleus; Dynorphins; G-Protein-Coupled Receptor Kinase 3; Immunoblotting; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Naltrexone; Narcotic Antagonists; Neurotransmitter Agents; Nucleus Accumbens; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Receptors, Opioid, kappa; Signal Transduction; Stress, Psychological; Swimming | 2008 |
Prodynorphin-derived peptides are critical modulators of anxiety and regulate neurochemistry and corticosterone.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amygdala; Animals; Anxiety; Brain Stem; Corticosterone; Corticotropin-Releasing Hormone; Dynorphins; Enkephalins; Exploratory Behavior; Female; Guanidines; Hypothalamus; Male; Maze Learning; Mesencephalon; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphinans; Naltrexone; Neuropeptide Y; Neuropeptides; Protein Precursors; Raphe Nuclei; Receptors, Opioid, kappa; Stress, Psychological | 2009 |
Dynorphin inhibits NEP activity in R1.1 mouse thymoma cells.
Topics: Animals; Cell Line, Tumor; Dynorphins; Mice; Naltrexone; Narcotic Antagonists; Neprilysin; Receptors, Opioid, kappa; Thiophenes; Thymoma; Thymus Neoplasms | 2008 |
A prolonged nitric oxide-dependent, opioid-mediated antinociceptive effect of hyperbaric oxygen in mice.
Topics: Acetic Acid; Analgesia; Analysis of Variance; Animals; beta-Endorphin; Citrulline; Dynorphins; Enkephalin, Methionine; Enzyme Inhibitors; Hyperbaric Oxygenation; Injections, Intraperitoneal; Male; Mice; Microinjections; Naltrexone; Narcotic Antagonists; Neurotransmitter Agents; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pain; Pain Measurement; Thiourea | 2009 |
Protection conferred by Corticotropin-releasing hormone in rat primary cortical neurons against chemical ischemia involves opioid receptor activation.
Topics: Animals; Brain Ischemia; Cell Death; Cells, Cultured; Corticotropin-Releasing Hormone; Dynorphins; Enkephalins; Indoles; Naltrexone; Narcotic Antagonists; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Potassium Cyanide; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone; Receptors, Opioid, delta; Receptors, Opioid, kappa; RNA, Messenger | 2009 |
Effect of non-dopaminergic drug treatment on Levodopa induced dyskinesias in MPTP monkeys: common implication of striatal neuropeptides.
Topics: Animals; Antiparkinson Agents; Benzoxazoles; Cocaine; Corpus Striatum; Disease Models, Animal; Docosahexaenoic Acids; Dopamine; Dopamine Uptake Inhibitors; Dynorphins; Dyskinesia, Drug-Induced; Enkephalins; Female; Iodine Isotopes; Levodopa; Macaca fascicularis; Naltrexone; Neuropeptides; Ovariectomy; Parkinsonian Disorders; Piperidines; Protein Precursors; RNA, Messenger; Sulfonamides; Tachykinins; Thiazoles; Time Factors | 2010 |
Kappa-opioid receptor-mediated modulation of innate immune response by dynorphin in teleost Channa punctatus.
Topics: Animals; Dynorphins; Fishes; Immunity, Innate; Naltrexone; Peptides; Phagocytosis; Receptors, Opioid, kappa | 2010 |
Behavioral stress may increase the rewarding valence of cocaine-associated cues through a dynorphin/kappa-opioid receptor-mediated mechanism without affecting associative learning or memory retrieval mechanisms.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analysis of Variance; Anesthetics, Local; Animals; Association Learning; Behavior, Animal; Cocaine; Conditioning, Operant; Cues; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Dynorphins; Exploratory Behavior; Male; Mental Recall; Mice; Mice, Inbred C57BL; Naltrexone; Narcotic Antagonists; Receptors, Opioid, kappa; Reward; Stress, Psychological; Swimming | 2010 |
Systemic κ-opioid receptor antagonism by nor-binaltorphimine reduces dependence-induced excessive alcohol self-administration in rats.
Topics: Administration, Inhalation; Alcohol Deterrents; Alcoholism; Animals; Dose-Response Relationship, Drug; Dynorphins; Ethanol; Injections, Subcutaneous; Male; Naltrexone; Narcotic Antagonists; Premedication; Rats; Rats, Wistar; Receptors, Opioid, kappa; Self Administration; Substance Withdrawal Syndrome | 2011 |
Exposure to cocaine alters dynorphin-mediated regulation of excitatory synaptic transmission in nucleus accumbens neurons.
Topics: Animals; Cocaine; Drug Interactions; Dynorphins; Excitatory Postsynaptic Potentials; Male; Naltrexone; Neurons; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Synaptic Transmission | 2011 |
Delayed postoperative latent pain sensitization revealed by the systemic administration of opioid antagonists in mice.
Topics: Animals; Dizocilpine Maleate; Dynorphins; Hyperalgesia; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Pain Threshold; Piperidines; Postoperative Complications; Reaction Time; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa; Remifentanil; Spinal Cord | 2011 |
Inhibitory effects of processed Aconiti tuber on morphine-induced conditioned place preference in rats.
Topics: Aconitum; Animals; Behavior, Addictive; Behavior, Animal; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Tolerance; Drugs, Chinese Herbal; Dynorphins; Male; Morphine Dependence; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Phytotherapy; Plant Tubers; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa | 2011 |
Activation of κ opioid receptors increases intrinsic excitability of dentate gyrus granule cells.
Topics: 4-Aminopyridine; Action Potentials; Animals; Benzeneacetamides; Dentate Gyrus; Dynorphins; GTP-Binding Proteins; Guanosine Diphosphate; Male; Mice; Mice, 129 Strain; Naltrexone; Neurons; Patch-Clamp Techniques; Potassium Channels; Pyrrolidines; Receptors, Opioid, kappa; Thionucleotides | 2011 |
The role of endogenous dynorphin in ethanol-induced state-dependent CPP.
Topics: Animals; Central Nervous System Depressants; Conditioning, Operant; Drug Administration Schedule; Dynorphins; Enkephalins; Ethanol; Female; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Naltrexone; Narcotic Antagonists; Protein Precursors; Sex Factors; Time Factors | 2012 |
YFa and analogs: investigation of opioid receptors in smooth muscle contraction.
Topics: Acetylcholine; Analgesics, Opioid; Animals; Cholinergic Agonists; Dynorphins; Enkephalin, Methionine; Guinea Pigs; Ileum; Male; Mice; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists; Neurotransmitter Agents; Oligopeptides; Receptors, Opioid; Vas Deferens | 2011 |
Stress produces aversion and potentiates cocaine reward by releasing endogenous dynorphins in the ventral striatum to locally stimulate serotonin reuptake.
Topics: Animals; Avoidance Learning; Brain; Cocaine; Corpus Striatum; Dopamine; Dynorphins; G-Protein-Coupled Receptor Kinase 3; Male; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Microinjections; Naltrexone; Narcotic Antagonists; Nicotine; Nucleus Accumbens; p38 Mitogen-Activated Protein Kinases; Raphe Nuclei; Receptors, Opioid, kappa; Reward; Serotonin; Serotonin Plasma Membrane Transport Proteins; Signal Transduction; Stress, Psychological; Substance Withdrawal Syndrome; Synaptosomes | 2012 |
Maternally administered sustained-release naltrexone in rats affects offspring neurochemistry and behaviour in adulthood.
Topics: Animals; Behavior, Animal; Brain; Delayed-Action Preparations; Dynorphins; Enkephalins; Female; Gene Expression; Male; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Narcotics; Neostriatum; Pregnancy; Prenatal Exposure Delayed Effects; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Self Administration | 2012 |
Protracted withdrawal from ethanol and enhanced responsiveness stress: regulation via the dynorphin/kappa opioid receptor system.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Alcoholism; Analgesics, Non-Narcotic; Animals; Anxiety; Dose-Response Relationship, Drug; Dynorphins; Ethanol; Male; Maze Learning; Motor Activity; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid, kappa; Stress, Psychological; Substance Withdrawal Syndrome | 2013 |
Chronic peripheral administration of kappa-opioid receptor antagonist advances puberty onset associated with acceleration of pulsatile luteinizing hormone secretion in female rats.
Topics: Animals; Drug Implants; Dynorphins; Female; Luteinizing Hormone; Naltrexone; Narcotic Antagonists; Nerve Tissue Proteins; Neurokinin B; Neurons; Ovary; Peptide Fragments; Puberty, Precocious; Random Allocation; Rats; Rats, Wistar; Receptors, Neurokinin-3; Receptors, Opioid, kappa; Sexual Maturation; Signal Transduction; Substance P; Weaning | 2013 |
Upregulated dynorphin opioid peptides mediate alcohol-induced learning and memory impairment.
Topics: Animals; CA3 Region, Hippocampal; Central Nervous System Depressants; Dynorphins; Ethanol; Glutamic Acid; Hippocampus; Learning; Maze Learning; Memory; Microdialysis; Naltrexone; Narcotic Antagonists; Radioimmunoassay; Rats; Rats, Wistar; Receptors, Opioid, kappa; Synaptic Transmission; Up-Regulation | 2013 |
Involvement of spinal cord opioid mechanisms in the acute antinociceptive effect of hyperbaric oxygen in mice.
Topics: Acetic Acid; Analgesia; Animals; beta-Endorphin; Dynorphins; Enkephalin, Methionine; Hyperbaric Oxygenation; Injections, Spinal; Male; Mice; Naltrexone; Narcotic Antagonists; Spinal Cord | 2013 |
Kappa opioid receptor activation decreases inhibitory transmission and antagonizes alcohol effects in rat central amygdala.
Topics: Amygdala; Animals; Benzeneacetamides; Dynorphins; Ethanol; Inhibitory Postsynaptic Potentials; Male; Naltrexone; Narcotic Antagonists; Patch-Clamp Techniques; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa | 2014 |
Zyklophin, a short-acting kappa opioid antagonist, induces scratching in mice.
Topics: Animals; Benzeneacetamides; Dose-Response Relationship, Drug; Dynorphins; Injections, Subcutaneous; Male; Mice; Mice, Knockout; Naltrexone; Peptide Fragments; Pruritus; Pyrrolidines; Radioligand Assay; Receptors, Opioid, kappa | 2014 |
Epigenetic regulation of spinal cord gene expression controls opioid-induced hyperalgesia.
Topics: Analgesics, Opioid; Animals; Antineoplastic Agents; Azepines; Benzamides; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Dynorphins; Epigenesis, Genetic; Gene Expression Regulation; Hydroxamic Acids; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Morphine; Naltrexone; Narcotic Antagonists; Pain Measurement; Spinal Cord; Vorinostat | 2014 |
The kappa-opioid receptor antagonist, nor-binaltorphimine (nor-BNI), decreases morphine withdrawal and the consequent conditioned place aversion in rats.
Topics: Animals; Conditioning, Psychological; Defecation; Dynorphins; Male; Morphine; Morphine Dependence; Motor Activity; Naltrexone; Narcotic Antagonists; Narcotics; Neurotransmitter Agents; Random Allocation; Rats, Long-Evans; Receptors, Opioid, kappa; Spatial Behavior; Substance Withdrawal Syndrome | 2015 |
Dynorphin activation of kappa opioid receptor reduces neuronal excitability in the paraventricular nucleus of mouse thalamus.
Topics: Animals; Barium; Cations; Dose-Response Relationship, Drug; Dynorphins; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Guanosine Diphosphate; Membrane Potentials; Mice, Inbred C57BL; Naltrexone; Narcotic Antagonists; Neurons; Neurotransmitter Agents; Paraventricular Hypothalamic Nucleus; Patch-Clamp Techniques; Receptors, Opioid, kappa; Sexual Maturation; Thionucleotides; Tissue Culture Techniques | 2015 |
Intrathecal morphine-3-glucuronide-induced nociceptive behavior via Delta-2 opioid receptors in the spinal cord.
Topics: Animals; Behavior, Animal; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Leucine; Injections, Spinal; Male; MAP Kinase Signaling System; Mice; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Nociception; Receptors, Opioid, delta; Spinal Cord | 2016 |
Two short-acting kappa opioid receptor antagonists (zyklophin and LY2444296) exhibited different behavioral effects from the long-acting antagonist norbinaltorphimine in mouse anxiety tests.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Dynorphins; Feeding Behavior; Male; Mice; Motor Activity; Naltrexone; Peptide Fragments; Proteins; Receptors, Opioid, kappa | 2016 |
Influence of dynorphin on estradiol- and cervical stimulation-induced prolactin surges in ovariectomized rats.
Topics: Animals; Dynorphins; Estradiol; Estrous Cycle; Female; Naltrexone; Narcotic Antagonists; Neurons; Ovariectomy; Prolactin; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa | 2016 |
Stress-Induced Reinstatement of Nicotine Preference Requires Dynorphin/Kappa Opioid Activity in the Basolateral Amygdala.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Basolateral Nuclear Complex; Clozapine; Conditioning, Operant; Drug-Seeking Behavior; Dynorphins; Extinction, Psychological; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Naltrexone; Narcotic Antagonists; Nicotine; Nicotinic Agonists; Proto-Oncogene Proteins c-fos; Receptors, Opioid, kappa; Reinforcement, Psychology; Yohimbine | 2016 |
Dynorphin Counteracts Orexin in the Paraventricular Nucleus of the Thalamus: Cellular and Behavioral Evidence.
Topics: Animals; Behavior, Addictive; Cocaine; Cocaine-Related Disorders; Drug Interactions; Dynorphins; Excitatory Postsynaptic Potentials; Extinction, Psychological; Male; Microinjections; Miniature Postsynaptic Potentials; Naltrexone; Orexins; Paraventricular Hypothalamic Nucleus; Rats; Reward; Self Administration | 2018 |
Lateralized kappa opioid receptor signaling from the amygdala central nucleus promotes stress-induced functional pain.
Topics: Analgesics, Opioid; Animals; Capsaicin; Central Amygdaloid Nucleus; Dynorphins; Hypothalamus; Male; Medulla Oblongata; Morphine; Naltrexone; Narcotic Antagonists; Pain; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Stress, Physiological | 2018 |
Maladaptive behavioral regulation in alcohol dependence: Role of kappa-opioid receptors in the bed nucleus of the stria terminalis.
Topics: Alcoholism; Animals; Conditioning, Operant; Dynorphins; Ethanol; Gene Expression Regulation; Male; Maze Learning; Naltrexone; Rats; Receptors, Opioid, kappa; RNA, Messenger; Self Administration; Septal Nuclei; Substance Withdrawal Syndrome; Up-Regulation; Vocalization, Animal | 2018 |
Dynorphin-kappa opioid receptor activity in the central amygdala modulates binge-like alcohol drinking in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Behavior, Animal; Binge Drinking; Central Amygdaloid Nucleus; Disease Models, Animal; Dynorphins; Genetic Techniques; Male; Mice; Mice, Inbred C57BL; Naltrexone; Receptors, Opioid, kappa | 2019 |
Kappa-opioid receptors, dynorphin, and cocaine addiction: a positron emission tomography study.
Topics: Adult; Brain; Carbon Radioisotopes; Case-Control Studies; Choice Behavior; Cocaine; Cocaine Smoking; Cocaine-Related Disorders; Dynorphins; Humans; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Neostriatum; Piperazines; Positron-Emission Tomography; Pyrrolidines; Receptors, Opioid, kappa; Stress, Psychological | 2019 |
Dynorphin and GABAA Receptor Signaling Contribute to Progesterone's Inhibition of the LH Surge in Female Mice.
Topics: Animals; Bicuculline; Dynorphins; Estradiol; Female; GABA Antagonists; Hypothalamus; Hypothalamus, Anterior; Kisspeptins; Luteinizing Hormone; Mice, Inbred C57BL; Naltrexone; Neurons; Organophosphorus Compounds; Ovariectomy; Progesterone; Receptors, GABA-A; Signal Transduction | 2020 |
Kappa opioid receptor controls neural stem cell differentiation via a miR-7a/Pax6 dependent pathway.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Basic Helix-Loop-Helix Transcription Factors; Cell Differentiation; Dynorphins; Gene Expression Regulation, Developmental; Hippocampus; Humans; Mice; MicroRNAs; Naltrexone; Nerve Tissue Proteins; Neural Stem Cells; Neurogenesis; PAX6 Transcription Factor; Receptors, Opioid, kappa; Signal Transduction | 2021 |
Amygdala dynorphin/κ opioid receptor system modulates depressive-like behavior in mice following chronic social defeat stress.
Topics: Amygdala; Animals; Behavior, Animal; Depressive Disorder, Major; Dynorphins; Extracellular Signal-Regulated MAP Kinases; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Naltrexone; Proto-Oncogene Proteins c-fos; Receptors, Opioid, kappa; Social Behavior; Social Defeat | 2022 |
Release of endogenous dynorphin opioids in the prefrontal cortex disrupts cognition.
Topics: Analgesics, Opioid; Animals; Cognition; Dynorphins; Male; Mice; Mice, Inbred C57BL; Naltrexone; Prefrontal Cortex; Receptors, Opioid, kappa | 2021 |
Comorbidities Are Complex: The Dynorphin/Kappa Opioid Receptor System in a Preclinical Model of Stress and Alcohol.
Topics: Comorbidity; Dynorphins; Ethanol; Naltrexone; Receptors, Opioid, kappa | 2022 |
Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications.
Topics: Animals; Aorta, Thoracic; Cocaine; Cyclic AMP; Electric Stimulation; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Mice; Muscle, Smooth; Opioid-Related Disorders; Rats; Receptors, Dopamine; Receptors, Opioid; Receptors, Serotonin; Substance-Related Disorders | 1998 |