naltrexone has been researched along with cocaine in 147 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (7.48) | 18.7374 |
| 1990's | 50 (34.01) | 18.2507 |
| 2000's | 37 (25.17) | 29.6817 |
| 2010's | 38 (25.85) | 24.3611 |
| 2020's | 11 (7.48) | 2.80 |
| Authors | Studies |
|---|---|
| Carroll, FI | 1 |
| Jolivette, LJ; Ward, KW | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Blumberg, H; Ikeda, C | 1 |
| Masukawa, Y; Misawa, M; Nagase, H; Shiozaki, Y; Suzuki, T | 1 |
| Doty, P; Dykstra, LA; Johnson, AB; Picker, MJ | 1 |
| Bilsky, EJ; Menkens, K; Porreca, F; Portoghese, PS; Reid, LD; Wild, KD | 1 |
| Byck, R; Compton, M; Fleming, J; Gawin, FH; Jatlow, P; Kosten, T; Kosten, TA; Silverman, DG | 1 |
| Bilsky, EJ; Delong, CL; Montegut, MJ; Reid, LD | 1 |
| Goldberg, SR; Grayson, NA; Jaffe, JH; Johnson, RE; Katz, JL; Rice, KC; Witkin, JM | 1 |
| Bansinath, M; Goldfrank, LR; Shukla, VK; Turndorf, H | 1 |
| Ramsey, NF; van Ree, JM | 2 |
| Mello, NK | 1 |
| Kamien, JB; Lukas, SE; Mello, NK; Mendelson, JH | 1 |
| Coen, KM; Corrigall, WA | 1 |
| Bree, MP; Lukas, SE; Mello, NK; Mendelson, JH | 1 |
| Schuster, CR; Snyder, M | 1 |
| De Vry, J; Donselaar, I; Van Ree, JM | 1 |
| Winger, G | 1 |
| Kleber, HD; Kosten, TR; Morgan, C | 1 |
| Mello, NK; Mendelson, JH | 1 |
| Corrigall, WA; Vaccarino, FJ | 1 |
| Williams, A | 1 |
| Carroll, ME; Kragh, R; Lac, ST; Newman, T; Walker, MJ | 1 |
| Bloom, FE; Ettenberg, A; Koob, GF; Pettit, HO | 1 |
| Dackis, CA; Gold, MS | 1 |
| Bilsky, EJ; French, ED; Glick, SD; Menkens, KA; Porreca, F; Reid, LD | 1 |
| Heidbreder, C; Shippenberg, TS | 1 |
| Archer, S; Glick, SD; Maisonneuve, IM; Raucci, J | 1 |
| Braida, D; Colombo, M; Gori, E; Groppetti, A; Parenti, M; Sacco, S; Sala, M | 1 |
| Funada, M; Misawa, M; Mori, T; Nagase, H; Suzuki, T | 1 |
| Archer, S; Glick, SD; Maisonneuve, IM | 1 |
| Carroll, ME; Comer, SD; Curtis, LK; Lac, ST | 1 |
| Misawa, M; Mori, T; Nagase, H; Suzuki, T; Tsuji, M | 1 |
| Kameyama, T; Mizutani, M; Ukai, M | 1 |
| Goldberg, SR; Heidbreder, C; Shippenberg, TS | 1 |
| Drieze, J; Lukas, SE; Mello, NK; Mendelson, JH | 1 |
| Bowen, WD; Holtzman, SG; Jones, DN; Portoghese, PS | 1 |
| Acquas, E; Di Chiara, G; Meloni, M | 1 |
| Bilsky, EJ; Glaccum, MB; Hubbell, CL; Porreca, F; Portoghese, PS; Reid, LD | 1 |
| Kameyama, T; Mori, E; Ukai, M | 1 |
| Babovic-Vuksanovic, D; de Vries, TJ; Elmer, G; Shippenberg, TS | 1 |
| France, CP; Gerak, LR | 1 |
| Heidbreder, C; LeFevour, A; Shippenberg, TS | 1 |
| Dworkin, SI; Hemby, SE; Smith, JE | 1 |
| Heidbreder, C; Shippenberg, TS; Shoaib, M | 1 |
| Cox, BM; Izenwasser, S; Katz, JL; Newman, AH | 1 |
| Bigelow, GE; Garner, JE; Preston, KL; Sullivan, JT; Walsh, SL | 1 |
| Litten, RZ | 1 |
| Cramer, CM; Hubbell, CL; Pabello, NG; Reid, LD | 1 |
| Lin, CE; Mello, NK; Negus, SS; Portoghese, PS | 1 |
| Holtzman, SG; Kimmel, HL | 1 |
| Gordon, FJ; Holtzman, SG; Patterson, AB | 1 |
| Boedeker, KL; Cramer, CM; Gardell, LR; Harris, JR; Hubbell, CL; Reid, LD | 1 |
| Rowlett, JK; Wilcox, KM; Woolverton, WL | 1 |
| Cramer, CM; Hubbell, CL; Reid, LD | 1 |
| DeMontis, MG; Dworkin, SI; Kim, SA; Martin, TJ; Sizemore, GM; Smith, JE | 1 |
| Gerrits, MA; Kuzmin, AV; Van Ree, JM | 1 |
| Brodkin, ES; Carlezon, WA; Duman, RS; Hiroi, N; Lane-Ladd, SB; Nestler, EJ; Neve, RL; Olson, VG; Thome, J | 1 |
| Anders, KA; Czapiga, M; Dallman, E; Kruschel, CK; Mitchem, LD; Panos, JJ; Steinpreis, RE | 1 |
| Hersh, D; Kranzler, HR; Mulgrew, CL; Van Kirk, J | 1 |
| Gerrits, MA; Ramsey, NF; Van Ree, JM | 1 |
| Grech, DM; Platt, DM; Rowlett, JK; Spealman, RD | 1 |
| Platt, DM; Rowlett, JK; Spealman, RD | 1 |
| Mello, NK; Negus, SS | 1 |
| Bian, D; Cannon, DG; Kim, SA; Martin, TJ; Porreca, F; Sizemore, GM; Smith, JE | 1 |
| Justice, JB; Sharpe, LG; Shippenberg, TS; Thompson, AC; Vaughan, RA; Zapata, A | 1 |
| Collins, SL; D'Addario, C; Gerdes, RM; Izenwasser, S | 1 |
| France, CP; Sell, SL | 1 |
| Mackler, SA; O'Brien, CP; Sengpiel, T; Stromberg, MF; Vogel, WH; Volpicelli, JR | 1 |
| Chavkin, C; Marton-Popovici, M; McLaughlin, JP | 1 |
| Martin, TJ; Roberts, DC; Ward, SJ | 1 |
| France, CP; McMahon, LR; Sell, SL | 1 |
| Izenwasser, S; Platt, DM; Rowlett, JK; Spealman, RD | 1 |
| Goldberg, SR; Justinova, Z; Munzar, P; Tanda, G | 1 |
| Butelman, ER; Ho, A; Kreek, MJ; Schlussman, SD; Zhang, Y | 1 |
| Ansonoff, MA; Hummel, M; Pintar, JE; Unterwald, EM | 1 |
| Negus, SS | 1 |
| Alekseyenko, OV; Bondar, NP; Burbach, JP; Gerrits, MA; Hordijk, M; Lesscher, HM; van Ree, JM | 1 |
| Sable, HJ; Steinpreis, RE; White, SL | 1 |
| France, CP; Koek, W; McMahon, LR; Sell, SL | 1 |
| Chavkin, C; Chavkin, TA; Li, S; McLaughlin, JP; Valdez, J | 1 |
| Fantoma, A; Gerra, G; Zaimovic, A | 1 |
| Chefer, VI; Shippenberg, TS | 1 |
| Comer, SD; Dackis, C; Kampman, K; Kleber, HD; O'Brien, CP; Rothenberg, JL; Sullivan, MA; Yu, E | 1 |
| Le Merrer, J; Stephens, DN | 1 |
| Jasmin, L; Narasaiah, M; Tien, D | 1 |
| Kaminski, RM; Shippenberg, TS; Witkin, JM | 1 |
| Antonilli, L; Cioce, AM; Giudici, FD; Grassi, MC; Nencini, P | 1 |
| Bienkowski, P; Kostowski, W; Mierzejewski, P; Stefanski, R | 1 |
| Roberts, DC; Ward, SJ | 1 |
| Co, C; Coller, M; Martin, TJ; Smith, JE | 1 |
| Ding, Z; Phillips, AG; Powell, JA; Raffa, RB; Rawls, SM; Ross, G; Stagliano, GW | 1 |
| Antapasis, J; Bolaños Guzmán, CA; Herrera, CM; Poveromo, LB; Wiley, MD | 1 |
| Achat-Mendes, C; Platt, DM; Rowlett, JK; Spealman, RD; Valdez, GR | 1 |
| Cashman, JR; Ghirmai, S; Koob, GF; Orio, L; Wee, S | 1 |
| Di Paolo, T; Grégoire, L; Lévesque, D; Morissette, M; Ouattara, B; Rouillard, C; Samadi, P; Tamim, MK | 1 |
| Aita, M; Bruchas, MR; Chavkin, C; Giardino, WJ; Hnasko, TS; Land, BB; Messinger, D; Palmiter, RD; Schattauer, S | 1 |
| Chavkin, C; Li, S; Schindler, AG | 1 |
| Chung, NN; Gibula-Bruzda, E; Izdebski, J; Kotlinska, JH; Kunce, D; Pachuta, A; Schiller, PW; Witkowska, E | 1 |
| Dong, Y; Mu, P; Neumann, PA; Panksepp, J; Schlüter, OM | 1 |
| Aklin, WM; Bigelow, GE; DeFulio, A; Donlin, WD; Everly, JJ; Fingerhood, M; Koffarnus, MN; Leoutsakos, JM; Silverman, K; Umbricht, A | 1 |
| Carlezon, WA; Chartoff, E; Pliakas, A; Potter, D; Rachlin, A; Sawyer, A | 1 |
| Carlezon, WA; Chartoff, EH; Cohen, BM; Damez-Werno, D; Potter, DN | 1 |
| Chudnovskaya, D; Cowan, A; Huang, P; Liu-Chen, LY; Rasakham, K; Wang, YJ | 1 |
| Friedman, TC; Hamid, A; Kieffer, B; Lutfy, K; Marquez, P; Nguyen, AT | 1 |
| Bühler, KM; Echeverry-Alzate, V; Giné, E; Gorriti, MÁ; Huertas, E; López-Moreno, JA; Olmos, P; Rodríguez de Fonseca, F; Santos, Á; Tuda-Arízcun, M | 1 |
| Koob, GF; Misra, KK; Schlosburg, JE; Vendruscolo, LF; Wee, S | 1 |
| Allen, CP; Leri, F; Zhou, Y | 1 |
| Chavkin, C; Chavkin, NW; Gustin, RM; Hagan, CE; Lemos, JC; Messinger, DI; Neumaier, JF; Schattauer, SS; Schindler, AG; Shankar, H; Smith, JS | 1 |
| Bailey, CP; Cordery, SF; Delgado-Charro, MB; Guy, RH; Husbands, SM; Ridzwan, IE; Taverner, A | 1 |
| Agovic, MS; Banerjee, SP; Chan, CY; Friedman, E; Jashanmal, I; Ragnauth, A; Sostris, V; Vidal, L | 1 |
| Askalsky, P; Berkower, EL; Comer, SD; Cooper, ZD; Foltin, RW; Haney, M; Jones, JD; Manubay, JM; Martinez, D; Mogali, S; Pines, A; Roux, P; Rubin, E; Saccone, PA; Sullivan, MA; Vosburg, SK; Walker, EA | 1 |
| Al-Hasani, R; Bruchas, MR; Foshage, AM; McCall, JG | 1 |
| Gibula-Bruzda, E; Izdebski, J; Kotlinska, JH; Witkowska, E | 1 |
| Clark, JK; Hammond, S; Keralapurath, MM; Wagner, JJ | 1 |
| Chavkin, C; Groblewski, PA; Phillips, PE; Willuhn, I; Zietz, C | 1 |
| Banks, ML; Cheng, K; Hutsell, BA; Negus, SS; Rice, KC | 1 |
| Abbott, S; Boyapati, V; Deakin, JF; Elliott, R; Erritzoe, D; Ersche, KD; Faluyi, Y; Faravelli, L; Fernandez-Egea, E; Flechais, RS; Kalk, NJ; Kuchibatla, SS; Lingford-Hughes, AR; McGonigle, J; Metastasio, A; Mick, I; Murphy, A; Nestor, L; Nutt, DJ; Orban, C; Passetti, F; Paterson, LM; Rabiner, EA; Reed, LJ; Robbins, TW; Smith, DG; Suckling, J; Tait, R; Taylor, EM; Waldman, AD | 1 |
| Eans, SO; Ganno, ML; Hunkele, A; Le Rouzic, V; Majumdar, S; Marrone, GF; McLaughlin, JP; Pasternak, GW; Subrath, JJ; Váradi, A | 1 |
| de Carvalho, CR; Takahashi, RN | 1 |
| Bühler, KM; Calleja-Conde, J; Echeverry-Alzate, V; Giné, E; Gual, A; López-Moreno, JA; Maldonado, R; Nadal, R; Rodríguez de Fonseca, F | 1 |
| Coggiano, M; Hiranita, T; Katz, JL; Mereu, M; Quarterman, JC; Tanda, G | 1 |
| Bardo, MT; Beckmann, JS; Hofford, RS | 1 |
| Camirand-Lemyre, F; Desharnais, B; Mireault, P; Skinner, CD | 1 |
| Bigelow, GE; DeFulio, A; Fingerhood, M; Holtyn, AF; Jarvis, BP; Long, L; Silverman, K; Umbricht, A | 1 |
| Ciccocioppo, R; de Guglielmo, G; Journigan, VB; Kallupi, M; Shen, Q; Yasuda, D; Zaveri, NT | 1 |
| Banks, ML; Cheng, K; Moerke, MJ; Negus, SS; Rice, KC | 1 |
| George, O; Kallupi, M; Martin-Fardon, R; Matzeu, A; Schweitzer, P | 1 |
| Negus, SS; Sakloth, F | 1 |
| Kreek, MJ; Reed, B; Windisch, KA | 1 |
| Giancola, JB; Keighron, JD; Lin, SC; Newman, AH; Scaglione, A; Tanda, G; Zanettini, C | 1 |
| Bigelow, GE; DeFulio, A; Fingerhood, M; Holtyn, AF; Jarvis, BP; Koffarnus, MN; Leoutsakos, JS; Silverman, K; Umbricht, A | 1 |
| Carson, RE; Chang, D; Foltin, R; Grassetti, A; Huang, Y; Lin, SF; Martinez, D; Matuskey, D; Nabulsi, N; Ropchan, J; Salling, M; Slifstein, M; Urban, N; Zheng, MQ | 1 |
| Freeman, KB; Huskinson, SL; Naylor, JE; Prisinzano, TE; Townsend, EA; Zamarripa, CA | 1 |
| Ayers, C; Chan, B; Freeman, M; Kansagara, D; Kondo, K; Korthuis, PT; Paynter, R | 1 |
| Azar, MR; Cunningham, JI; Dean, RL; Deaver, DR; Eyerman, DJ; Koob, GF; Todtenkopf, MS | 1 |
| Kreek, MJ; Morochnik, M; Reed, B; Windisch, KA | 1 |
| Hallahan, JE; Hillhouse, TM; Husbands, SM; Jutkiewicz, EM; Koppenhaver, PO; Meurice, C; Olson, KM; Ostovar, M; Rysztak, LG; Sears, BF; Traynor, JR; West, JL | 1 |
| Graham, DP; Hamon, SC; Hillhouse, M; Kosten, TR; Lawson, WB; Ling, W; Nielsen, DA; Nielsen, EM; Rotrosen, J; Saxon, AJ; Settles-Reaves, BD; Shmueli-Blumberg, D; Shores-Wilson, K; Trivedi, MH; Walker, R | 1 |
| Cami-Kobeci, G; Cippitelli, A; Husbands, SM; Martinez, M; Toll, L; Zribi, G | 1 |
| Cippitelli, A; Toll, L; Zribi, G | 1 |
| Alcorn, JL; Bolin, BL; Hays, LR; Lile, JA; Rayapati, AO; Regnier, SD; Reynolds, AR; Rush, CR; Stoops, WW | 1 |
| Bachtell, RK; Brown, KT; Levis, SC; Levy, C; O'Neill, CE; Rice, KC; Watkins, LR | 1 |
| Balise, RR; Castillo, F; Feaster, DJ; Hu, MC; Liu, Y; Luo, SX; Nunes, EV; Rotrosen, J; Saxon, AJ; Weiss, RD | 1 |
7 review(s) available for naltrexone and cocaine
| Article | Year |
|---|---|
2002 Medicinal Chemistry Division Award address: monoamine transporters and opioid receptors. Targets for addiction therapy.
Topics: Animals; Biogenic Monoamines; Biological Transport; Carrier Proteins; Cocaine; Fluorescent Dyes; Humans; Isoquinolines; Ligands; Morphinans; Narcotic Antagonists; Piperidines; Protein Binding; Radioisotopes; Receptors, Opioid; Structure-Activity Relationship; Substance-Related Disorders | 2003 |
Preclinical evaluation of the effects of buprenorphine, naltrexone and desipramine on cocaine self-administration.
Topics: Animals; Buprenorphine; Cocaine; Desipramine; Humans; Macaca mulatta; Naltrexone; Self Administration | 1990 |
Pharmacological modifications of cocaine and opioid self-administration.
Topics: Animals; Chlorpromazine; Cocaine; Naltrexone; Narcotics; Receptors, Dopamine; Receptors, Opioid; Reinforcement, Psychology; Self Administration | 1988 |
Clinical investigations of drug effects in women.
Topics: Buprenorphine; Cocaine; Desipramine; Female; Heroin Dependence; Humans; Male; Naltrexone; Opioid-Related Disorders; Sex Factors; Substance-Related Disorders | 1986 |
New insights and treatments: opiate withdrawal and cocaine addiction.
Topics: Brain Chemistry; Clonidine; Cocaine; Dopamine; Humans; Methadone; Naltrexone; Norepinephrine; Substance Withdrawal Syndrome; Substance-Related Disorders | 1984 |
Interactions between kappa opioid agonists and cocaine. Preclinical studies.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Psychological; Discrimination Learning; Humans; Naloxone; Naltrexone; Receptors, Opioid, kappa; Self Administration | 2000 |
A systematic review and meta-analysis of medications for stimulant use disorders in patients with co-occurring opioid use disorders.
Topics: Analgesics, Opioid; Antidepressive Agents; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; Female; Humans; Methadone; Naltrexone; Opioid-Related Disorders | 2020 |
11 trial(s) available for naltrexone and cocaine
| Article | Year |
|---|---|
Intravenous cocaine challenges during naltrexone maintenance: a preliminary study.
Topics: Adult; Blood Pressure; Cocaine; Double-Blind Method; Female; Heart Rate; Humans; Male; Naltrexone; Placebo Effect; Substance Abuse, Intravenous | 1992 |
Effects of naltrexone on response to intravenous cocaine, hydromorphone and their combination in humans.
Topics: Adult; Buprenorphine; Cocaine; Cross-Over Studies; Double-Blind Method; Drug Interactions; Humans; Hydromorphone; Liver; Male; Naltrexone; Narcotic Antagonists; Narcotics; Respiration; Substance-Related Disorders | 1996 |
The validity of self-reported cocaine use in two groups of cocaine abusers.
Topics: Adult; Carbamazepine; Cocaine; Cocaine-Related Disorders; Double-Blind Method; Female; Humans; Interview, Psychological; Male; Naltrexone; Predictive Value of Tests; Psychometrics; Reproducibility of Results; Self Disclosure; Substance Abuse Detection | 1999 |
Injectable, sustained-release naltrexone for the treatment of opioid dependence: a randomized, placebo-controlled trial.
Topics: Adolescent; Adult; Cocaine; Delayed-Action Preparations; Double-Blind Method; Drug Administration Schedule; Female; Heroin Dependence; Humans; Injections, Subcutaneous; Male; Methadone; Middle Aged; Naltrexone; Narcotics; Placebos; Secondary Prevention; Substance Abuse Detection; Treatment Outcome | 2006 |
Short-term efficacy of Disulfiram or Naltrexone in reducing positive urinalysis for both cocaine and cocaethylene in cocaine abusers: a pilot study.
Topics: Adult; Cocaine; Cocaine-Related Disorders; Cognitive Behavioral Therapy; Combined Modality Therapy; Disulfiram; Humans; Naltrexone; Narcotic Antagonists; Patient Compliance; Pilot Projects; Time Factors; Treatment Outcome | 2007 |
Employment-based reinforcement of adherence to depot naltrexone in unemployed opioid-dependent adults: a randomized controlled trial.
Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Cocaine; Delayed-Action Preparations; Dopamine Uptake Inhibitors; Employment; Female; Humans; Injections, Subcutaneous; Male; Medication Adherence; Middle Aged; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Outcome Assessment, Health Care; Reinforcement, Psychology; Salaries and Fringe Benefits; Young Adult | 2011 |
Effects of acute oral naltrexone on the subjective and physiological effects of oral D-amphetamine and smoked cocaine in cocaine abusers.
Topics: Administration, Oral; Adult; Cardiovascular System; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; Cross-Over Studies; Dextroamphetamine; Dopamine Uptake Inhibitors; Double-Blind Method; Female; Humans; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Smoking | 2013 |
The Imperial College Cambridge Manchester (ICCAM) platform study: An experimental medicine platform for evaluating new drugs for relapse prevention in addiction. Part A: Study description.
Topics: Adult; Behavior, Addictive; Biomedical Research; Brain; Cocaine; Cross-Over Studies; Drug Discovery; Ethanol; Female; Humans; Impulsive Behavior; Magnetic Resonance Imaging; Male; Middle Aged; Naltrexone; Neurokinin-1 Receptor Antagonists; Pharmaceutical Preparations; Receptors, Dopamine D3; Receptors, Neurokinin-1; Reward; Secondary Prevention; Substance-Related Disorders | 2015 |
The effects of extended-release injectable naltrexone and incentives for opiate abstinence in heroin-dependent adults in a model therapeutic workplace: A randomized trial.
Topics: Adult; Black or African American; Cocaine; Delayed-Action Preparations; Female; Heroin; Humans; Injections; Male; Middle Aged; Motivation; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Substance Abuse Detection; Workplace | 2019 |
Moderation of buprenorphine therapy for cocaine dependence efficacy by variation of the Prodynorphin gene.
Topics: Buprenorphine; Buprenorphine, Naloxone Drug Combination; Cocaine; Cocaine-Related Disorders; Delayed-Action Preparations; Enkephalins; Humans; Injections, Intramuscular; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Protein Precursors | 2022 |
Naltrexone-bupropion combinations do not affect cocaine self-administration in humans.
Topics: Blood Pressure; Bupropion; Cocaine; Drug Combinations; Humans; Naltrexone | 2023 |
129 other study(ies) available for naltrexone and cocaine
| Article | Year |
|---|---|
Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure.
Topics: Algorithms; Animals; Dogs; Haplorhini; Humans; Pharmaceutical Preparations; Pharmacokinetics; Rats; Species Specificity; Tissue Distribution | 2005 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Naltrexone, morphine and cocaine interactions in mice and rats.
Topics: Animals; Cocaine; Drug Interactions; Lethal Dose 50; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Reaction Time; Reflex | 1978 |
The role of mu- and kappa-opioid receptors in cocaine-induced conditioned place preference.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Buprenorphine; Chlorides; Cocaine; Conditioning, Psychological; Lithium; Lithium Chloride; Male; Naltrexone; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1992 |
Discriminative stimulus properties of cocaine, alone and in combination with buprenorphine, morphine and naltrexone.
Topics: Animals; Buprenorphine; Cocaine; Dextroamphetamine; Discrimination, Psychological; Dose-Response Relationship, Drug; Drug Combinations; Male; Morphine; Naltrexone; Rats; Sodium Chloride | 1992 |
Cocaine place preference is blocked by the delta-opioid receptor antagonist, naltrindole.
Topics: Animals; Cocaine; Conditioning, Operant; Indoles; Male; Morphinans; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Lew | 1992 |
Opioidergic modulation of cocaine conditioned place preferences.
Topics: Analysis of Variance; Animals; Cocaine; Conditioning, Psychological; Male; Methadone; Naltrexone; Rats; Rats, Inbred Strains; Reference Values; Reinforcement, Psychology | 1992 |
The partial opioid agonist, buprenorphine, protects against lethal effects of cocaine.
Topics: Animals; Brain; Buprenorphine; Cocaine; Dose-Response Relationship, Drug; Methadone; Mice; Mice, Inbred Strains; Morphine; Naltrexone; Receptors, Opioid; Receptors, Opioid, mu; Seizures | 1991 |
Antagonism of acute cocaine toxicity by buprenorphine.
Topics: Analysis of Variance; Animals; Buprenorphine; Cocaine; Dose-Response Relationship, Drug; L-Lactate Dehydrogenase; Male; Mice; Naloxone; Naltrexone | 1991 |
Intracerebroventricular naltrexone treatment attenuates acquisition of intravenous cocaine self-administration in rats.
Topics: Animals; Brain; Cocaine; Drug Interactions; Infusions, Intravenous; Injections, Intraventricular; Male; Naltrexone; Rats; Rats, Inbred Strains; Reinforcement, Psychology; Self Administration | 1991 |
Effects of naltrexone on cocaine self-administration by rhesus monkey.
Topics: Animals; Buprenorphine; Cocaine; Eating; Macaca mulatta; Naltrexone; Self Administration | 1990 |
Opiate antagonists reduce cocaine but not nicotine self-administration.
Topics: Animals; Cocaine; Conditioning, Operant; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nicotine; Rats; Reinforcement Schedule; Self Administration | 1991 |
Chronic pretreatment with naltrexone facilitates acquisition of intravenous cocaine self-administration in rats.
Topics: Animals; Cocaine; Conditioning, Operant; Injections, Intravenous; Male; Naltrexone; Rats; Rats, Inbred Strains; Self Administration | 1990 |
Buprenorphine and naltrexone effects on cocaine self-administration by rhesus monkeys.
Topics: Animals; Buprenorphine; Cocaine; Conditioning, Operant; Eating; Female; Macaca mulatta; Male; Naltrexone; Self Administration | 1990 |
NIDA's Medication Development Program--1989.
Topics: Acquired Immunodeficiency Syndrome; Brain; Cocaine; Drug and Narcotic Control; Female; Heroin Dependence; Humans; Infant, Newborn; Methadone; Methadyl Acetate; Naltrexone; Pregnancy; Psychotropic Drugs; Research Support as Topic; Risk Factors; Substance Abuse, Intravenous; Substance-Related Disorders | 1989 |
Food deprivation and acquisition of intravenous cocaine self-administration in rats: effect of naltrexone and haloperidol.
Topics: Animals; Body Weight; Cocaine; Food Deprivation; Haloperidol; Male; Naltrexone; Rats; Rats, Inbred Strains; Reinforcement, Psychology; Self Administration | 1989 |
Role of opioid antagonists in treating intravenous cocaine abuse.
Topics: Adult; Buprenorphine; Cocaine; Female; Humans; Injections, Intravenous; Male; Methadone; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Substance-Related Disorders | 1989 |
Antagonist treatment in nucleus accumbens or periaqueductal grey affects heroin self-administration.
Topics: Animals; Cocaine; Heroin; Male; Microinjections; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Periaqueductal Gray; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Self Administration | 1988 |
Primary care of parenteral substance abusers.
Topics: Acquired Immunodeficiency Syndrome; Administration, Intranasal; Antibodies, Viral; Body Weight; Cocaine; Female; Heart Diseases; Hepatitis; Heroin Dependence; HIV Antibodies; Humans; Injections, Intradermal; Injections, Intravenous; Kidney Diseases; Male; Menstruation Disturbances; Methadone; Naltrexone; Nervous System Diseases; Primary Health Care; Respiratory Tract Diseases; Substance-Related Disorders | 1986 |
Effects of naltrexone on intravenous cocaine self-administration in rats during food satiation and deprivation.
Topics: Animals; Cocaine; Diarrhea; Food Deprivation; Male; Naltrexone; Nasal Mucosa; Posture; Rats; Rats, Inbred Strains; Salivation; Self Administration; Time Factors | 1986 |
Heroin and cocaine intravenous self-administration in rats: mediation by separate neural systems.
Topics: Animals; Cocaine; Conditioning, Operant; Dose-Response Relationship, Drug; Flupenthixol; Heroin; Infusions, Parenteral; Male; Motor Activity; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Opioid; Self Administration | 1982 |
Cocaine self-administration and naltrindole, a delta-selective opioid antagonist.
Topics: Animals; Cocaine; Conditioning, Operant; Drug Implants; Female; Male; Morphine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; Receptors, Opioid, delta; Self Administration | 1995 |
The delta-opioid receptor antagonist naltrindole prevents sensitization to the conditioned rewarding effects of cocaine.
Topics: Animals; Association Learning; Cocaine; Conditioning, Operant; Drug Interactions; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Reward; Sensitivity and Specificity | 1995 |
Kappa opioid inhibition of morphine and cocaine self-administration in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Cocaine; Dose-Response Relationship, Drug; Extinction, Psychological; Female; Morphine; Naltrexone; Narcotics; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reinforcement, Psychology; Self Administration | 1995 |
Behavioral and biochemical evidence of opioidergic involvement in cocaine sensitization.
Topics: Adenylyl Cyclases; Animals; Cocaine; Drug Tolerance; Male; Motor Activity; Naltrexone; Nucleus Accumbens; Opioid Peptides; Rats; Rats, Wistar; Receptors, Dopamine D1; Substance-Related Disorders | 1995 |
Attenuation of the discriminative stimulus properties of cocaine by delta-opioid receptor antagonists.
Topics: Animals; Benzylidene Compounds; Cocaine; Discrimination Learning; Dose-Response Relationship, Drug; Male; Naltrexone; Rats; Rats, Inbred F344; Receptors, Opioid, delta | 1994 |
U50,488, a kappa opioid receptor agonist, attenuates cocaine-induced increases in extracellular dopamine in the nucleus accumbens of rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cocaine; Dopamine; Extracellular Space; Female; Naltrexone; Nucleus Accumbens; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa | 1994 |
Effects of buprenorphine and naltrexone on reinstatement of cocaine-reinforced responding in rats.
Topics: Animals; Benzimidazoles; Buprenorphine; Cocaine; Dose-Response Relationship, Drug; Drug Interactions; Male; Naltrexone; Rats; Rats, Wistar; Receptors, Opioid, mu; Reinforcement, Psychology | 1993 |
The role of delta-opioid receptor subtypes in cocaine- and methamphetamine-induced place preferences.
Topics: Animals; Benzylidene Compounds; Cocaine; Conditioning, Psychological; Male; Methamphetamine; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Reinforcement, Psychology | 1994 |
Opioid peptides selective for receptor types modulate cocaine-induced behavioral responses in mice.
Topics: Animals; Behavior, Animal; Cocaine; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Naltrexone; Opioid Peptides | 1994 |
Inhibition of cocaine-induced sensitization by the delta-opioid receptor antagonist naltrindole.
Topics: Animals; Cocaine; Male; Motor Activity; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta | 1993 |
Naltrexone-buprenorphine interactions: effects on cocaine self-administration.
Topics: Animals; Buprenorphine; Cocaine; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Combinations; Eating; Female; Macaca mulatta; Male; Naltrexone; Reinforcement Schedule; Self Administration | 1993 |
Delta-opioid receptor antagonists attenuate motor activity induced by amphetamine but not cocaine.
Topics: Amphetamine; Animals; Cocaine; Dose-Response Relationship, Drug; Enkephalin, Leucine-2-Alanine; Male; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta | 1993 |
Blockade of delta-opioid receptors in the nucleus accumbens prevents ethanol-induced stimulation of dopamine release.
Topics: Animals; Cocaine; Dopamine; Ethanol; Indoles; Male; Morphinans; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta | 1993 |
Naltrindole, an opioid delta receptor antagonist, blocks cocaine-induced facilitation of responding for rewarding brain stimulation.
Topics: Analysis of Variance; Animals; Brain; Cocaine; Electric Stimulation; Indoles; Male; Morphinans; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Reinforcement, Psychology; Self Stimulation | 1993 |
Cocaine-like discriminative stimulus properties of the delta-selective opioid receptor agonist, [D-Pen2,L-Pen5]enkephalin, in the rat.
Topics: Animals; Cocaine; Discrimination Learning; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Generalization, Stimulus; Indoles; Morphinans; Naltrexone; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu | 1993 |
Lack of involvement of delta-opioid receptors in mediating the rewarding effects of cocaine.
Topics: Animals; Benzazepines; Cocaine; Conditioning, Operant; Dose-Response Relationship, Drug; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Reward; Self Administration; Time Factors | 1995 |
Discriminative stimulus effects of nalbuphine in rhesus monkeys.
Topics: Analgesics, Opioid; Animals; Cocaine; Dextroamphetamine; Discrimination Learning; Female; Macaca mulatta; Male; Nalbuphine; Naltrexone | 1996 |
kappa-Opioid receptor agonists prevent sensitization to the conditioned rewarding effects of cocaine.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzeneacetamides; Cocaine; Conditioning, Psychological; Dopamine; Male; Naltrexone; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reward | 1996 |
The effects of eticlopride and naltrexone on responding maintained by food, cocaine, heroin and cocaine/heroin combinations in rats.
Topics: Analysis of Variance; Animals; Cocaine; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Combinations; Eating; Heroin; Male; Naltrexone; Rats; Rats, Inbred F344; Receptors, Opioid; Salicylamides | 1996 |
Differential role of delta-opioid receptors in the development and expression of behavioral sensitization to cocaine.
Topics: Animals; Behavior, Animal; Cocaine; Male; Motor Activity; Naltrexone; Narcotic Antagonists; Narcotics; Nicotine; Nicotinic Agonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta | 1996 |
The cocaine-like behavioral effects of meperidine are mediated by activity at the dopamine transporter.
Topics: Animals; Behavior, Animal; Carrier Proteins; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Male; Membrane Glycoproteins; Membrane Transport Proteins; Meperidine; Models, Molecular; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Nerve Tissue Proteins; Rats; Rats, Sprague-Dawley; Saimiri | 1996 |
International update: new findings on promising medications.
Topics: Acamprosate; Alcohol Deterrents; Alcoholism; Animals; Clinical Trials as Topic; Cocaine; Comorbidity; Europe; Humans; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Taurine; United States | 1996 |
Isradipine in combination with naltrexone as a medicine for treating cocaine abuse.
Topics: Animals; Calcium Channel Blockers; Cocaine; Drug Therapy, Combination; Electric Stimulation; Isradipine; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Substance-Related Disorders | 1997 |
Effects of kappa opioids on cocaine self-administration by rhesus monkeys.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Circadian Rhythm; Cocaine; Dose-Response Relationship, Drug; Ethylketocyclazocine; Female; Macaca mulatta; Male; Naloxone; Naltrexone; Pyrrolidines; Receptors, Opioid, kappa; Self Administration; Substance-Related Disorders | 1997 |
Mu opioid agonists potentiate amphetamine- and cocaine-induced rotational behavior in the rat.
Topics: Amphetamine; Animals; Cocaine; Drug Synergism; Male; Motor Activity; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 1997 |
Naltrindole, a selective delta-opioid receptor antagonist, potentiates the lethal effects of cocaine by a central mechanism of action.
Topics: Animals; Blood Pressure; Central Nervous System; Cisterna Magna; Cocaine; Drug Synergism; Heart Rate; Infusions, Intravenous; Injections; Male; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Seizures | 1997 |
Isradipine combined with naltrexone persistently reduces the reward-relevant effects of cocaine and alcohol.
Topics: Animals; Body Weight; Calcium Channel Blockers; Central Nervous System Depressants; Cocaine; Conditioning, Operant; Drinking; Drug Interactions; Ethanol; Isradipine; Male; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Sprague-Dawley; Reward | 1998 |
Self-administration of cocaine-heroin combinations by rhesus monkeys: antagonism by naltrexone.
Topics: Animals; Cocaine; Dose-Response Relationship, Drug; Drug Combinations; Female; Heroin; Macaca mulatta; Male; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Receptors, Opioid, mu; Self Administration | 1998 |
A combination of isradipine and naltrexone blocks cocaine's enhancement of a cocaine place preference.
Topics: Animals; Calcium Channel Blockers; Cocaine; Conditioning, Operant; Dose-Response Relationship, Drug; Isradipine; Male; Mental Recall; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Sprague-Dawley; Substance-Related Disorders | 1998 |
Effects of beta-funaltrexamine on dose-effect curves for heroin self-administration in rats: comparison with alteration of [3H]DAMGO binding to rat brain sections.
Topics: Analgesics, Opioid; Animals; Brain; Caudate Nucleus; Cocaine; Culture Techniques; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Heroin; Heroin Dependence; Motivation; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Radioligand Assay; Rats; Receptors, Opioid, mu; Self Administration | 1998 |
Kappa-opioid receptor blockade with nor-binaltorphimine modulates cocaine self-administration in drug-naive rats.
Topics: Animals; Behavior, Animal; Cocaine; Dose-Response Relationship, Drug; Male; Naltrexone; Narcotics; Nicotinic Antagonists; Rats; Rats, Wistar; Receptors, Opioid, kappa; Self Administration; Time Factors | 1998 |
Regulation of cocaine reward by CREB.
Topics: Animals; Cocaine; Conditioning, Psychological; Cyclic AMP Response Element-Binding Protein; Dose-Response Relationship, Drug; Dynorphins; Gene Expression; Gene Expression Regulation; Gene Transfer Techniques; Genetic Vectors; Naltrexone; Narcotic Antagonists; Neurons; Nucleus Accumbens; Point Mutation; Rats; Receptors, Opioid, kappa; Reward; RNA, Messenger; Simplexvirus | 1998 |
The effects of the naltrexone implant on rodent social interactions and cocaine-induced conditioned place preference.
Topics: Animals; Cocaine; Conditioning, Psychological; Drug Implants; Drug Interactions; Grooming; Male; Motor Activity; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Social Behavior | 1999 |
Naltrexone affects cocaine self-administration in naïve rats through the ventral tegmental area rather than dopaminergic target regions.
Topics: Animals; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Self Administration; Time Factors; Ventral Tegmental Area | 1999 |
Discriminative stimulus effects of morphine in squirrel monkeys: stimulants, opioids, and stimulant-opioid combinations.
Topics: Amphetamine; Analgesics, Opioid; Anesthetics, Local; Animals; Anti-Anxiety Agents; Cocaine; Discrimination Learning; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Combinations; Fentanyl; Male; Morphine; Naltrexone; Narcotic Antagonists; Piperazines; Receptors, Opioid; Saimiri; Selective Serotonin Reuptake Inhibitors | 1999 |
Cocaine-like discriminative stimulus effects of heroin in squirrel monkeys: role of active metabolites and opioid receptor mechanisms.
Topics: Analgesics, Opioid; Animals; Cocaine; Discrimination Learning; Dopamine Uptake Inhibitors; Heroin; Male; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Saimiri | 2000 |
Antagonism of delta(2)-opioid receptors by naltrindole-5'-isothiocyanate attenuates heroin self-administration but not antinociception in rats.
Topics: Analgesics, Opioid; Animals; Cocaine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Heroin; Injections, Intraventricular; Isothiocyanates; Male; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain Measurement; Rats; Rats, Inbred F344; Receptors, Opioid, delta; Reinforcement, Psychology; Self Administration | 2000 |
Kappa-opioid receptor activation modifies dopamine uptake in the nucleus accumbens and opposes the effects of cocaine.
Topics: Analysis of Variance; Animals; Autoradiography; Benzeneacetamides; Carrier Proteins; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Drug Administration Schedule; Drug Antagonism; Extracellular Space; Injections, Intraperitoneal; Injections, Subcutaneous; Iodine Radioisotopes; Linear Models; Male; Membrane Glycoproteins; Membrane Transport Proteins; Microdialysis; Naltrexone; Nerve Tissue Proteins; Nucleus Accumbens; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa | 2000 |
Kappa opioid agonists alter dopamine markers and cocaine-stimulated locomotor activity.
Topics: Analgesics; Animals; Benzeneacetamides; Benzomorphans; Caudate Nucleus; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Drug Interactions; Male; Membrane Glycoproteins; Membrane Transport Proteins; Motor Activity; Naltrexone; Nerve Net; Nerve Tissue Proteins; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa | 2001 |
Cocaine and amphetamine attenuate the discriminative stimulus effects of naltrexone in opioid-dependent rhesus monkeys.
Topics: Amphetamine; Animals; Cocaine; Discrimination, Psychological; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Female; Macaca mulatta; Male; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Substance Withdrawal Syndrome | 2002 |
Effect of naltrexone on oral consumption of concurrently available ethanol and cocaine in the rat.
Topics: Administration, Oral; Alcohol Drinking; Animals; Behavior, Addictive; Cocaine; Dose-Response Relationship, Drug; Ethanol; Male; Naltrexone; Rats; Rats, Wistar | 2002 |
Kappa opioid receptor antagonism and prodynorphin gene disruption block stress-induced behavioral responses.
Topics: Analgesia; Animals; Behavior, Animal; Cocaine; Drug Synergism; Enkephalins; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Naltrexone; Narcotic Antagonists; Pain Threshold; Protein Precursors; Reaction Time; Receptors, Opioid, kappa; Reward; Spatial Behavior; Stress, Physiological; Swimming | 2003 |
Beta-funaltrexamine affects cocaine self-administration in rats responding on a progressive ratio schedule of reinforcement.
Topics: Animals; Cocaine; Conditioning, Operant; Male; Microinjections; Naltrexone; Narcotic Antagonists; Neostriatum; Nucleus Accumbens; Rats; Rats, Inbred F344; Reinforcement Schedule; Self Administration; Ventral Tegmental Area | 2003 |
Cocaine and other indirect-acting monoamine agonists differentially attenuate a naltrexone discriminative stimulus in morphine-treated rhesus monkeys.
Topics: Amphetamine; Animals; Biogenic Monoamines; Cocaine; Discrimination Learning; Disease Models, Animal; Dopamine Agents; Dopamine Uptake Inhibitors; Drug Interactions; Imipramine; Macaca mulatta; Morphine; Morphine Dependence; Naltrexone; Narcotics; Substance Withdrawal Syndrome | 2004 |
Opioid partial agonist effects of 3-O-methylnaltrexone in rhesus monkeys.
Topics: Adenylyl Cyclases; Animals; Cocaine; Discrimination Learning; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Heroin; Heroin Dependence; Macaca mulatta; Male; Morphine; Morphine Derivatives; Naltrexone; Narcotics; Quaternary Ammonium Compounds; Receptors, Opioid, mu; Self Administration | 2004 |
The opioid antagonist naltrexone reduces the reinforcing effects of Delta 9 tetrahydrocannabinol (THC) in squirrel monkeys.
Topics: Analgesics, Non-Narcotic; Anesthetics, Local; Animals; Behavior, Animal; Cocaine; Conditioning, Operant; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Male; Naltrexone; Narcotic Antagonists; Reinforcement Schedule; Reinforcement, Psychology; Saimiri; Self Administration | 2004 |
Effect of the kappa opioid agonist R-84760 on cocaine-induced increases in striatal dopamine levels and cocaine-induced place preference in C57BL/6J mice.
Topics: Analysis of Variance; Animals; Behavior, Animal; Chromatography, High Pressure Liquid; Cocaine; Conditioning, Operant; Dopamine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Food; Male; Mice; Mice, Inbred C57BL; Microdialysis; Motor Activity; Naltrexone; Narcotic Antagonists; Neostriatum; Pyrrolidines; Receptors, Opioid, kappa; Thiazines | 2004 |
Genetic and pharmacological manipulation of mu opioid receptors in mice reveals a differential effect on behavioral sensitization to cocaine.
Topics: Adaptation, Physiological; Animals; Behavior, Animal; Cocaine; Dopamine Uptake Inhibitors; Mice; Mice, Knockout; Motor Activity; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu | 2004 |
Effects of the kappa opioid agonist U50,488 and the kappa opioid antagonist nor-binaltorphimine on choice between cocaine and food in rhesus monkeys.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Behavior, Addictive; Choice Behavior; Cocaine; Dose-Response Relationship, Drug; Eating; Macaca mulatta; Male; Naltrexone; Receptors, Opioid, kappa | 2004 |
Mu-opioid receptors are not involved in acute cocaine-induced locomotor activity nor in development of cocaine-induced behavioral sensitization in mice.
Topics: Animals; Behavior, Animal; Cocaine; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin; Stimulation, Chemical | 2005 |
Effects of chronic naltrexone treatment in rats on place preference and locomotor activation after acute administration of cocaethylene or ethanol plus cocaine.
Topics: Animals; Cocaine; Conditioning, Psychological; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Combinations; Ethanol; Male; Motor Activity; Naltrexone; Rats; Rats, Sprague-Dawley | 2004 |
Monoaminergic drugs and directly observable signs of LAAM withdrawal in rhesus monkeys.
Topics: Adrenergic alpha-Agonists; Amphetamine; Analgesics, Opioid; Animals; Antidepressive Agents, Tricyclic; Biogenic Monoamines; Clonidine; Cocaine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Female; Haloperidol; Imipramine; Macaca mulatta; Male; Methadyl Acetate; Muscle Rigidity; Naltrexone; Narcotic Antagonists; Respiratory Mechanics; Salivation; Substance Withdrawal Syndrome | 2005 |
Social defeat stress-induced behavioral responses are mediated by the endogenous kappa opioid system.
Topics: Analysis of Variance; Anesthetics, Local; Animals; Behavior, Animal; Cocaine; Conditioning, Operant; Enkephalins; Immobility Response, Tonic; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Naltrexone; Narcotic Antagonists; Pain Measurement; Protein Precursors; Reaction Time; Receptors, Opioid, kappa; Social Behavior; Stress, Psychological | 2006 |
Naltrexone and buprenorphine combination in the treatment of opioid dependence.
Topics: Adult; Affect; Buprenorphine; Cocaine; Cocaine-Related Disorders; Female; Heroin Dependence; Humans; Liver; Male; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Psychiatric Status Rating Scales; Substance Abuse Detection; Survival Analysis | 2006 |
Paradoxical effects of prodynorphin gene deletion on basal and cocaine-evoked dopaminergic neurotransmission in the nucleus accumbens.
Topics: Analgesics; Animals; Area Under Curve; Behavior, Animal; Benzeneacetamides; Chromatography, High Pressure Liquid; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Dynorphins; Electrochemistry; Mice; Mice, Inbred C57BL; Mice, Knockout; Microdialysis; Motor Activity; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Pyrrolidines | 2006 |
Food-induced behavioral sensitization, its cross-sensitization to cocaine and morphine, pharmacological blockade, and effect on food intake.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analgesics, Opioid; Animals; Benzazepines; Benzodiazepines; Cocaine; Conditioning, Psychological; Dopamine Antagonists; Dopamine Uptake Inhibitors; Drug Interactions; Eating; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Feeding Behavior; Male; Mice; Mice, Inbred C57BL; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Receptors, Dopamine D1; Sulpiride | 2006 |
Noradrenaline is necessary for the hedonic properties of addictive drugs.
Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Appetitive Behavior; Benzazepines; Biphenyl Compounds; Bupropion; Carbidopa; Cocaine; Dopamine beta-Hydroxylase; Dopamine Uptake Inhibitors; Droxidopa; Female; Genotype; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Knockout; Morphine; Naltrexone; Narcotic Antagonists; Neurokinin-1 Receptor Antagonists; Norepinephrine; Receptors, Adrenergic, alpha-1; Receptors, Dopamine D1; Reward; Substance-Related Disorders | 2006 |
Pharmacological and genetic manipulation of kappa opioid receptors: effects on cocaine- and pentylenetetrazol-induced convulsions and seizure kindling.
Topics: Analgesics; Animals; Behavior, Animal; Benzeneacetamides; Cocaine; Dose-Response Relationship, Drug; Drug Interactions; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Naltrexone; Narcotic Antagonists; Pentylenetetrazole; Pyrrolidines; Receptors, Opioid, kappa; Seizures | 2007 |
History of cocaine self-administration alters morphine reinforcement in the rat.
Topics: Analysis of Variance; Animals; Cocaine; Conditioning, Operant; Dose-Response Relationship, Drug; Infusions, Intravenous; Injections, Intraperitoneal; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Self Administration | 2007 |
Microinjection of the delta-opioid receptor selective antagonist naltrindole 5'-isothiocyanate site specifically affects cocaine self-administration in rats responding under a progressive ratio schedule of reinforcement.
Topics: Anesthetics, Local; Animals; Behavior, Animal; Brain; Cocaine; Isothiocyanates; Male; Microinjections; Naltrexone; Rats; Rats, Inbred F344; Receptors, Opioid, delta; Reinforcement Schedule; Self Administration; Time Factors | 2007 |
Micro-opioid receptor alkylation in the ventral pallidum and ventral tegmental area, but not in the nucleus accumbens, attenuates the effects of heroin on cocaine self-administration in rats.
Topics: Alkylating Agents; Alkylation; Analysis of Variance; Animals; Behavior, Animal; Cocaine; Conditioning, Operant; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Synergism; Globus Pallidus; Heroin; Male; Naltrexone; Narcotics; Nucleus Accumbens; Rats; Rats, Inbred F344; Receptors, Opioid, mu; Self Administration; Ventral Tegmental Area | 2008 |
The kappa-opioid receptor antagonist nor-BNI inhibits cocaine and amphetamine, but not cannabinoid (WIN 52212-2), abstinence-induced withdrawal in planarians: an instance of 'pharmacologic congruence'.
Topics: Amphetamine; Analgesics; Analysis of Variance; Animals; Behavior, Animal; Benzoxazines; Cocaine; Disease Models, Animal; Dopamine Uptake Inhibitors; Drug Interactions; Morpholines; Naltrexone; Naphthalenes; Narcotic Antagonists; Planarians; Substance Withdrawal Syndrome; Time Factors | 2008 |
Kappa-opioid system regulates the long-lasting behavioral adaptations induced by early-life exposure to methylphenidate.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Anxiety; Behavior, Animal; Central Nervous System Stimulants; Cocaine; Conditioning, Psychological; Food Preferences; Male; Methylphenidate; Motor Activity; Naltrexone; Psychotropic Drugs; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Stress, Psychological | 2009 |
Intravenous self-administration of etonitazene alone and combined with cocaine in rhesus monkeys: comparison with heroin and antagonism by naltrexone and naloxonazine.
Topics: Animals; Benzimidazoles; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Drug Interactions; Female; Heroin; Injections, Intravenous; Macaca mulatta; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Receptors, Opioid, mu; Reinforcement, Psychology; Self Administration; Substance Abuse, Intravenous | 2009 |
Inhibition of kappa opioid receptors attenuated increased cocaine intake in rats with extended access to cocaine.
Topics: Animals; CHO Cells; Cocaine; Conditioning, Operant; Cricetinae; Cricetulus; Drug Interactions; Male; Naltrexone; Rats; Rats, Wistar; Receptors, Opioid, kappa; Reinforcement Schedule; Self Administration | 2009 |
Effect of non-dopaminergic drug treatment on Levodopa induced dyskinesias in MPTP monkeys: common implication of striatal neuropeptides.
Topics: Animals; Antiparkinson Agents; Benzoxazoles; Cocaine; Corpus Striatum; Disease Models, Animal; Docosahexaenoic Acids; Dopamine; Dopamine Uptake Inhibitors; Dynorphins; Dyskinesia, Drug-Induced; Enkephalins; Female; Iodine Isotopes; Levodopa; Macaca fascicularis; Naltrexone; Neuropeptides; Ovariectomy; Parkinsonian Disorders; Piperidines; Protein Precursors; RNA, Messenger; Sulfonamides; Tachykinins; Thiazoles; Time Factors | 2010 |
Activation of the kappa opioid receptor in the dorsal raphe nucleus mediates the aversive effects of stress and reinstates drug seeking.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analysis of Variance; Animals; Cocaine; Enzyme-Linked Immunosorbent Assay; Immunohistochemistry; Lentivirus; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Naltrexone; Raphe Nuclei; Receptors, Opioid, kappa; Stress, Physiological; Ventral Tegmental Area | 2009 |
Behavioral stress may increase the rewarding valence of cocaine-associated cues through a dynorphin/kappa-opioid receptor-mediated mechanism without affecting associative learning or memory retrieval mechanisms.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analysis of Variance; Anesthetics, Local; Animals; Association Learning; Behavior, Animal; Cocaine; Conditioning, Operant; Cues; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Dynorphins; Exploratory Behavior; Male; Mental Recall; Mice; Mice, Inbred C57BL; Naltrexone; Narcotic Antagonists; Receptors, Opioid, kappa; Reward; Stress, Psychological; Swimming | 2010 |
Influence of new deltorphin analogues on reinstatement of cocaine-induced conditioned place preference in rats.
Topics: Animals; Behavior, Addictive; Behavioral Research; Cocaine; Conditioning, Psychological; Infusions, Intraventricular; Maze Learning; Motor Activity; Naltrexone; Narcotic Antagonists; Oligopeptides; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Opioid, delta; Reward | 2010 |
Exposure to cocaine alters dynorphin-mediated regulation of excitatory synaptic transmission in nucleus accumbens neurons.
Topics: Animals; Cocaine; Drug Interactions; Dynorphins; Excitatory Postsynaptic Potentials; Male; Naltrexone; Neurons; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Synaptic Transmission | 2011 |
Blockade of kappa opioid receptors attenuates the development of depressive-like behaviors induced by cocaine withdrawal in rats.
Topics: Analysis of Variance; Animals; Cocaine; Conditioning, Operant; Depression; Disease Models, Animal; Dopamine Uptake Inhibitors; Drug Administration Routes; Immobility Response, Tonic; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid, kappa; Reinforcement Schedule; Self Administration; Substance Withdrawal Syndrome; Swimming; Time Factors | 2012 |
Repeated exposure to the κ-opioid receptor agonist salvinorin A modulates extracellular signal-regulated kinase and reward sensitivity.
Topics: Animals; Cocaine; Cyclic AMP Response Element-Binding Protein; Diterpenes, Clerodane; Drug Interactions; Extracellular Signal-Regulated MAP Kinases; Male; Naltrexone; Nucleus Accumbens; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reward; Self Stimulation; Signal Transduction; Time Factors | 2011 |
Sex difference in κ-opioid receptor (KOPR)-mediated behaviors, brain region KOPR level and KOPR-mediated guanosine 5'-O-(3-[35S]thiotriphosphate) binding in the guinea pig.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Non-Narcotic; Animals; Brain; Cocaine; Dopamine Uptake Inhibitors; Female; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Male; Mice; Motor Activity; Movement; Naltrexone; Narcotic Antagonists; Posture; Rats; Receptors, Opioid, kappa; Sex Characteristics | 2011 |
The rewarding action of acute cocaine is reduced in β-endorphin deficient but not in μ opioid receptor knockout mice.
Topics: Animals; Behavior, Animal; beta-Endorphin; Cocaine; Conditioning, Operant; Male; Mice; Mice, Knockout; Morphine; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu; Reward | 2012 |
Cocaine reverses the naltrexone-induced reduction in operant ethanol self-administration: the effects on immediate-early gene expression in the rat prefrontal cortex.
Topics: Acamprosate; Alcohol Deterrents; Alcohol Drinking; Animals; Carrier Proteins; Cocaine; Conditioning, Operant; Cyclooxygenase 2; Dose-Response Relationship, Drug; Gene Expression; Genes, fos; Genes, Immediate-Early; Homer Scaffolding Proteins; Male; Motor Activity; Naltrexone; Narcotic Antagonists; Prefrontal Cortex; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Self Administration; Taurine | 2012 |
A combination of buprenorphine and naltrexone blocks compulsive cocaine intake in rodents without producing dependence.
Topics: Animals; Buprenorphine; Cocaine; Cocaine-Related Disorders; Male; Naloxone; Naltrexone; Rats; Rats, Wistar; Substance Withdrawal Syndrome | 2012 |
Effect of food restriction on cocaine locomotor sensitization in Sprague-Dawley rats: role of kappa opioid receptors.
Topics: Animals; Cocaine; Corticosterone; Dose-Response Relationship, Drug; Food Deprivation; Male; Motor Activity; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa | 2013 |
Stress produces aversion and potentiates cocaine reward by releasing endogenous dynorphins in the ventral striatum to locally stimulate serotonin reuptake.
Topics: Animals; Avoidance Learning; Brain; Cocaine; Corpus Striatum; Dopamine; Dynorphins; G-Protein-Coupled Receptor Kinase 3; Male; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Microinjections; Naltrexone; Narcotic Antagonists; Nicotine; Nucleus Accumbens; p38 Mitogen-Activated Protein Kinases; Raphe Nuclei; Receptors, Opioid, kappa; Reward; Serotonin; Serotonin Plasma Membrane Transport Proteins; Signal Transduction; Stress, Psychological; Substance Withdrawal Syndrome; Synaptosomes | 2012 |
A non-rewarding, non-aversive buprenorphine/naltrexone combination attenuates drug-primed reinstatement to cocaine and morphine in rats in a conditioned place preference paradigm.
Topics: Animals; Behavior, Animal; Buprenorphine; Cocaine; Conditioning, Psychological; Cues; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Therapy, Combination; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Sprague-Dawley; Reward | 2014 |
Neuropsychopharmacological actions of taurine.
Topics: Amino Acids; Animals; Cocaine; Conditioning, Psychological; Extracellular Space; Locomotion; Models, Biological; Naltrexone; Neostriatum; Nervous System; Oligopeptides; Psychotropic Drugs; Rats; Receptors, N-Methyl-D-Aspartate; Taurine | 2013 |
Locus coeruleus kappa-opioid receptors modulate reinstatement of cocaine place preference through a noradrenergic mechanism.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic alpha-2 Receptor Agonists; Adrenergic beta-1 Receptor Antagonists; Adrenergic beta-Antagonists; Animals; Betaxolol; Clonidine; Cocaine; Conditioning, Psychological; Drug-Seeking Behavior; Locus Coeruleus; Male; Mice; Mice, Inbred C57BL; Naltrexone; Propanolamines; Propranolol; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Receptors, Opioid, kappa | 2013 |
Involvement of delta and mu opioid receptors in the acute and sensitized locomotor action of cocaine in mice.
Topics: Animals; Cocaine; Humans; Mice; Motor Activity; Naltrexone; Oligopeptides; Pain Measurement; Receptors, Opioid, delta; Receptors, Opioid, mu | 2013 |
Cocaine- or stress-induced metaplasticity of LTP in the dorsal and ventral hippocampus.
Topics: Animals; Cocaine; Corticosterone; Dopamine Uptake Inhibitors; Drug Administration Schedule; Excitatory Postsynaptic Potentials; Hippocampus; Hormone Antagonists; In Vitro Techniques; Long-Term Potentiation; Male; Mifepristone; Mineralocorticoid Receptor Antagonists; Motor Activity; Naltrexone; Rats; Rats, Sprague-Dawley; Spironolactone; Stress, Psychological | 2014 |
Repeated stress exposure causes strain-dependent shifts in the behavioral economics of cocaine in rats.
Topics: Animals; Cocaine; Dopamine Uptake Inhibitors; Drug-Seeking Behavior; Economics, Behavioral; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred WKY; Rats, Wistar; Self Administration; Stress, Psychological; Swimming | 2015 |
Effects of the kappa opioid receptor antagonist nor-binaltorphimine (nor-BNI) on cocaine versus food choice and extended-access cocaine intake in rhesus monkeys.
Topics: Analysis of Variance; Animals; Cocaine; Conditioning, Operant; Drug-Seeking Behavior; Food Preferences; Macaca mulatta; Male; Naltrexone; Narcotic Antagonists; Receptors, Opioid, kappa; Self Administration | 2016 |
Synthesis and characterization of a dual kappa-delta opioid receptor agonist analgesic blocking cocaine reward behavior.
Topics: Analgesics, Opioid; Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Psychological; Dopamine Uptake Inhibitors; Drug Evaluation, Preclinical; Male; Mice, Inbred C57BL; Mice, Knockout; Molecular Structure; Morphinans; Naltrexone; Nociception; Nuclear Receptor Subfamily 1, Group F, Member 1; Random Allocation; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reward; Spatial Behavior | 2015 |
Cannabidiol disrupts the reconsolidation of contextual drug-associated memories in Wistar rats.
Topics: Animals; Cannabidiol; Cocaine; Conditioning, Classical; Cues; Disease Models, Animal; Male; Memory; Mental Recall; Morphine; Naltrexone; Rats; Rats, Wistar; Reward | 2017 |
Nalmefene is effective at reducing alcohol seeking, treating alcohol-cocaine interactions and reducing alcohol-induced histone deacetylases gene expression in blood.
Topics: Alcohol Drinking; Animals; Cocaine; Dose-Response Relationship, Drug; Drug Interactions; Ethanol; Gene Expression Regulation, Enzymologic; Histone Deacetylases; Male; Naltrexone; Rats; Rats, Wistar; Structure-Activity Relationship | 2016 |
Lack of Specific Involvement of (+)-Naloxone and (+)-Naltrexone on the Reinforcing and Neurochemical Effects of Cocaine and Opioids.
Topics: Analgesics, Opioid; Anesthetics; Animals; Brain; Cocaine; Conditioning, Operant; Discrimination, Psychological; Dopamine; Extinction, Psychological; Male; Microdialysis; Naloxone; Naltrexone; Narcotic Antagonists; Piperidines; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Remifentanil; Self Administration; Time Factors | 2016 |
Rearing environment differentially modulates cocaine self-administration after opioid pretreatment: A behavioral economic analysis.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Cocaine; Economics, Behavioral; Environment; Male; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Self Administration; Substance-Related Disorders; Time Factors | 2016 |
Procedure for the Selection and Validation of a Calibration Model I-Description and Application.
Topics: Calibration; Chromatography, Liquid; Cocaine; Models, Statistical; Naltrexone; Quality Control; Reference Standards; Tandem Mass Spectrometry | 2017 |
Factors associated with using opiates while under extended-release naltrexone blockade: A descriptive pilot study.
Topics: Adult; Behavior, Addictive; Cocaine; Delayed-Action Preparations; Female; Humans; Male; Naltrexone; Narcotic Antagonists; Opiate Alkaloids; Opioid-Related Disorders; Pilot Projects; Randomized Controlled Trials as Topic | 2018 |
Buprenorphine requires concomitant activation of NOP and MOP receptors to reduce cocaine consumption.
Topics: Animals; Behavior, Animal; Buprenorphine; Cocaine; Conditioning, Operant; Cycloheptanes; Dopamine Uptake Inhibitors; Naltrexone; Narcotic Antagonists; Nociceptin Receptor; Piperidines; Rats; Receptors, Opioid; Receptors, Opioid, mu; Self Administration | 2018 |
Maintenance on naltrexone+amphetamine decreases cocaine-vs.-food choice in male rhesus monkeys.
Topics: Administration, Intravenous; Animals; Choice Behavior; Cocaine; Dextroamphetamine; Dose-Response Relationship, Drug; Drug Interactions; Food; Macaca mulatta; Male; Morphine; Naltrexone; Receptors, Opioid, mu; Reinforcement, Psychology; Self Administration | 2017 |
Dynorphin Counteracts Orexin in the Paraventricular Nucleus of the Thalamus: Cellular and Behavioral Evidence.
Topics: Animals; Behavior, Addictive; Cocaine; Cocaine-Related Disorders; Drug Interactions; Dynorphins; Excitatory Postsynaptic Potentials; Extinction, Psychological; Male; Microinjections; Miniature Postsynaptic Potentials; Naltrexone; Orexins; Paraventricular Hypothalamic Nucleus; Rats; Reward; Self Administration | 2018 |
Naltrexone maintenance fails to alter amphetamine effects on intracranial self-stimulation in rats.
Topics: Amphetamine; Animals; Central Nervous System Stimulants; Cocaine; Deep Brain Stimulation; Dose-Response Relationship, Drug; Male; Medial Forebrain Bundle; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Sprague-Dawley; Self Stimulation; Substance-Related Disorders | 2018 |
Naltrexone and nalmefene attenuate cocaine place preference in male mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics, Opioid; Animals; Cocaine; Conditioning, Psychological; Dose-Response Relationship, Drug; Locomotion; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists | 2018 |
Pharmacological classification of centrally acting drugs using EEG in freely moving rats: an old tool to identify new atypical dopamine uptake inhibitors.
Topics: Animals; Central Nervous System Agents; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Discovery; Electroencephalography; Heroin; Ketamine; Male; Methylphenidate; Modafinil; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 2019 |
Kappa-opioid receptors, dynorphin, and cocaine addiction: a positron emission tomography study.
Topics: Adult; Brain; Carbon Radioisotopes; Case-Control Studies; Choice Behavior; Cocaine; Cocaine Smoking; Cocaine-Related Disorders; Dynorphins; Humans; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Neostriatum; Piperazines; Positron-Emission Tomography; Pyrrolidines; Receptors, Opioid, kappa; Stress, Psychological | 2019 |
Kappa opioid agonists reduce oxycodone self-administration in male rhesus monkeys.
Topics: Analgesics, Opioid; Animals; Behavior, Addictive; Cocaine; Diterpenes, Clerodane; Dose-Response Relationship, Drug; Macaca mulatta; Male; Morphinans; Naltrexone; Narcotic Antagonists; Oxycodone; Receptors, Opioid, kappa; Reinforcement, Psychology; Self Administration; Spiro Compounds | 2020 |
Samidorphan, an opioid receptor antagonist, attenuates drug-induced increases in extracellular dopamine concentrations and drug self-administration in male Wistar rats.
Topics: Amphetamine; Animals; Cocaine; Dopamine; Ethanol; Humans; Male; Microdialysis; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Oxycodone; Rats; Rats, Wistar; Receptors, Opioid; Receptors, Opioid, mu; Self Administration; Substance-Related Disorders | 2021 |
Nalmefene, a mu opioid receptor antagonist/kappa opioid receptor partial agonist, potentiates cocaine motivation but not intake with extended access self-administration in adult male mice.
Topics: Analgesics, Opioid; Animals; Cocaine; Male; Mice; Mice, Inbred C57BL; Motivation; Naltrexone; Narcotic Antagonists; Receptors, Opioid, kappa; Receptors, Opioid, mu; Self Administration | 2021 |
The Buprenorphine Analogue BU10119 Attenuates Drug-Primed and Stress-Induced Cocaine Reinstatement in Mice.
Topics: Buprenorphine; Cocaine; Naltrexone; Receptors, Opioid, mu | 2021 |
PPL-138 (BU10038): A bifunctional NOP/mu partial agonist that reduces cocaine self-administration in rats.
Topics: Animals; Cocaine; Dose-Response Relationship, Drug; Female; Isoquinolines; Male; Naltrexone; Nociceptin; Opioid Peptides; Phenylpropionates; Rats; Receptors, Opioid; Receptors, Opioid, mu; Self Administration | 2022 |
PPL-103: A mixed opioid partial agonist with desirable anti-cocaine properties.
Topics: Analgesics, Opioid; Animals; Cocaine; Cocaine-Related Disorders; Humans; Naltrexone; Rats; Receptors, Opioid, kappa; Receptors, Opioid, mu; Self Administration | 2022 |
Toll-like receptor 4 antagonists reduce cocaine-primed reinstatement of drug seeking.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Dose-Response Relationship, Drug; Drug-Seeking Behavior; Extinction, Psychological; Lipopolysaccharides; Naltrexone; Rats; Rats, Sprague-Dawley; Self Administration; Toll-Like Receptor 4 | 2023 |
Risks of returning to opioid use at treatment entry and early in opioid use disorder treatment: Role of non-opioid substances.
Topics: Analgesics, Opioid; Buprenorphine; Cocaine; Humans; Methadone; Naltrexone; Opiate Substitution Treatment; Opioid-Related Disorders | 2023 |