naltrexone has been researched along with chlornaltrexamine in 72 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 43 (59.72) | 18.7374 |
| 1990's | 13 (18.06) | 18.2507 |
| 2000's | 12 (16.67) | 29.6817 |
| 2010's | 4 (5.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Caruso, TP; Jiang, JB; Larson, DL; Portoghese, PS; Takemori, AE | 2 |
| Kastin, AJ; Kersh, D; Wyatt, A; Zadina, JE | 1 |
| Bilotta, JM; Brackeen, MF; Feldman, PL; James, MK; Leighton, HJ; Schuster, SV | 1 |
| Mueller, J; Quock, RM | 1 |
| Lee, SY; Rhee, HM | 1 |
| LoPresti, D; Porreca, F; Ward, SJ | 1 |
| Frischknecht, HR; Siegfried, B | 2 |
| Clark, MJ; Medzihradsky, F; Nordby, GL | 1 |
| Dougall, IG; Leff, P | 2 |
| Burks, TF; Kramer, TH; Wire, WS | 1 |
| Chavkin, C; Opheim, KE; Wimpey, TL | 1 |
| Christie, MJ; North, RA; Williams, JT | 1 |
| Hayes, AG; Sheehan, MJ; Tyers, MB | 2 |
| DeLander, GE; Portoghese, PS; Takemori, AE | 1 |
| Herz, A; Höllt, V; Morris, BJ | 1 |
| Costa, T; Herz, A; Klinz, FJ; Vachon, L | 1 |
| Frischknecht, HR; Lazega, D; Siegfried, B; Waser, PG | 1 |
| Bloom, FE; Chavkin, C | 1 |
| Akil, H; Houghten, RA; Lewis, ME; Walker, JM; Woods, JH; Young, EA | 1 |
| Gosnell, BA; Grace, M; Levine, AS | 1 |
| Portoghese, PS; Takemori, AE | 1 |
| Portoghese, PS; Rein, MD; Takemori, AE | 1 |
| Corbett, AD; Kosterlitz, HW | 1 |
| Portoghese, PS; Schoenecker, JW; Takemori, AE | 1 |
| Corbett, AD; Kosterlitz, HW; Traynor, JR | 1 |
| Frischknecht, HR; Riggio, G; Siegfried, B; Waser, PG | 2 |
| Chavkin, C; Goldstein, A | 2 |
| Chavkin, C; Goldstein, A; James, IF | 1 |
| Chavkin, C; Cox, BM | 1 |
| Fischli, W; Goldstein, A; James, IF | 1 |
| Armstrong, MJ; Larson, AA | 1 |
| Caruso, TP; Larson, DL; Portoghese, PS; Takemori, AE | 2 |
| Ayhan, IH; Portoghese, PS; Takemori, AE; Tulunay, FC | 1 |
| Blume, AJ; Fantozzi, R; Mullikin-Kilpatrick, D | 1 |
| Messing, RB; Portoghese, PS; Sparber, SB; Takemori, AE | 1 |
| Portoghese, PS; Takemori, AE; Ward, SJ | 2 |
| Burks, TF; Porreca, F | 1 |
| Delander, GE; Takemori, AE | 1 |
| Corder, CN; Nieder, GL | 1 |
| Lucas, TS; Quock, RM | 1 |
| Conn, CA; Kluger, MJ; Kozak, W | 1 |
| Bidlack, JM; Joseph, DB | 1 |
| Kim, YH; Lim, JS; Song, DK; Suh, HW; Tseng, LF | 1 |
| Childers, SR; Konkoy, CS | 1 |
| Mosberg, HI; Porreca, F; Raffa, RB; Wild, KD | 1 |
| George, SR; Kouvelas, A; O'Dowd, BF; Pak, Y; Rasmussen, J; Scheideler, MA | 1 |
| Corbett, AD; McKnight, AT; Menzies, JR; Nicholson, JR; Paterson, SJ | 1 |
| Baamonde, A; Gutiérrez, M; Hidalgo, A; Menéndez, L; SanMartín, S | 1 |
| Balestra, B; Brecha, NC; D'Agostino, G; Fiori, E; Minnis, J; Sternini, C; Tonini, M | 1 |
| Sadée, W; Surratt, CK; Wang, D | 1 |
| Broadbear, JH; Burke, TF; Husbands, SM; Lewis, JW; Sumpter, TL; Traynor, JR; Woods, JH | 1 |
| Liu, JG; Prather, PL | 1 |
| Bilsky, EJ; Raehal, KM; Sadée, W; Wang, D | 1 |
| Lucas, JL; Quillan, JM; Sadée, W; Wang, D; Winans, K | 1 |
| Borgland, SL; Christie, MJ; Connor, M; Furness, JB; Osborne, PB | 1 |
| Caron, MG; Chavkin, C; Czyzyk, TA; Lefkowitz, RJ; McLaughlin, JP; Myers, LC; Pintar, JE; Zarek, PE | 1 |
| Martin, TJ; McIntosh, S; Smith, JE | 1 |
| Chung, E; Dickens, AS; Emmanouil, DE; Han, S; Heckert, RW; Ohgami, Y; Quock, RM | 1 |
| Virk, MS; Williams, JT | 1 |
| Arttamangkul, S; Birdsong, WT; Virk, MS; Williams, JT | 1 |
| Aicher, SA; Arttamangkul, S; Bobeck, EN; Hegarty, DM; Ingram, SL; Macey, TA; Morgan, MM | 1 |
| Cleary, DR; Fyfe, LW; Ingram, SL; Macey, TA; Morgan, MM | 1 |
| Williams, JT | 1 |
| Huang, TS; Lin, CC; Liu, YP; Tung, CS | 1 |
72 other study(ies) available for naltrexone and chlornaltrexamine
| Article | Year |
|---|---|
Synthesis and pharmacologic characterization of an alkylating analogue (chlornaltrexamine) of naltrexone with ultralong-lasting narcotic antagonist properties.
Topics: Alkylating Agents; Analgesics; Animals; Humans; In Vitro Techniques; Male; Mice; Molecular Conformation; Morphine; Morphine Dependence; Naloxone; Naltrexone; Narcotic Antagonists; Nitrogen Mustard Compounds; Rats; Receptors, Opioid; Time Factors | 1979 |
6beta-[N,N-Bis(2-chloroethyl)amino]-17-(cyclopropylmethyl)-4,5alpha-epoxy-3,14-dihydroxymorphinan(chlornaltrexamine) a potent opioid receptor alkylating agent with ultralong narcotic antagonist actitivty.
Topics: Alkylating Agents; Analgesia; Binding, Competitive; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Nitrogen Mustard Compounds; Receptors, Opioid | 1978 |
Tyr-MIF-1 and hemorphin can act as opiate agonists as well as antagonists in the guinea pig ileum.
Topics: Amino Acid Sequence; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Hemoglobins; Ileum; In Vitro Techniques; Male; Molecular Sequence Data; Morphine; MSH Release-Inhibiting Hormone; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists; Peptide Fragments; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1992 |
Opioid receptor activity of GI 87084B, a novel ultra-short acting analgesic, in isolated tissues.
Topics: Alkylation; Animals; Enkephalin, Leucine; Guinea Pigs; Ileum; Kinetics; Male; Mice; Mice, Inbred Strains; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists; Piperidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Remifentanil; Vas Deferens | 1991 |
Protection by U-50,488H against beta-chlornaltrexamine antagonism of nitrous oxide antinociception in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics; Animals; Fentanyl; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Nitrous Oxide; Pain; Pyrrolidines; Sufentanil | 1991 |
Cardiovascular action of methionine enkephalin (met-enkephalin) in conscious and anesthetized rabbits.
Topics: Anesthesia; Animals; Blood Pressure; Cardiovascular Physiological Phenomena; Cardiovascular System; Consciousness; Enkephalin, Methionine; Male; Naltrexone; Rabbits; Receptors, Opioid; Receptors, Opioid, mu | 1990 |
Opioid agonist affinity in the guinea-pig ileum and mouse vas deferens.
Topics: Animals; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Guinea Pigs; Ileum; Male; Methadone; Mice; Morphine; Morphine Derivatives; Naltrexone; Receptors, Opioid; Vas Deferens | 1990 |
Relationship between behavioral and nociceptive changes in attacked mice: effects of opiate antagonists.
Topics: Animals; Behavior, Animal; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Nociceptors; Species Specificity | 1989 |
Relationship between opioid-receptor occupancy and stimulation of low-Km GTPase in brain membranes.
Topics: Animals; Brain; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; GTP Phosphohydrolases; Guanosine Triphosphate; Magnesium; Membranes; Naltrexone; Oligopeptides; Phosphoric Monoester Hydrolases; Rats; Rats, Inbred Strains; Receptors, Opioid; Sodium | 1989 |
Estimation of affinities and efficacies for kappa-receptor agonists in guinea-pig ileum.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Binding, Competitive; Cyclazocine; Electric Stimulation; Ethylketocyclazocine; Guinea Pigs; In Vitro Techniques; Male; Models, Biological; Morphinans; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa | 1989 |
In vitro comparison of efficacies of "full" kappa opioid agonists.
Topics: Animals; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscles; Myenteric Plexus; Naltrexone; Narcotics; Receptors, Opioid; Receptors, Opioid, kappa | 1989 |
Effects of chronic morphine administration on the mu and delta opioid responses in the CA1 region of the rat hippocampus.
Topics: Animals; Drug Tolerance; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hippocampus; In Vitro Techniques; Male; Morphine; Naltrexone; Phosphorylation; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1989 |
Cellular mechanisms of opioid tolerance: studies in single brain neurons.
Topics: Animals; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; In Vitro Techniques; Locus Coeruleus; Male; Membrane Potentials; Morphine; Morphine Derivatives; Naltrexone; Neurons; Potassium; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu | 1987 |
Cross-protection of mu and delta opioid receptors in the mouse vas deferens.
Topics: Animals; Female; Kinetics; Male; Mice; Mice, Inbred C57BL; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Vas Deferens | 1986 |
Role of the spinal cord in the development of opiate tolerance and dependence.
Topics: Animals; Drug Tolerance; Naltrexone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Rats; Receptors, Opioid; Spinal Cord | 1987 |
Opioid gene expression in rat striatum is modulated via opioid receptors: evidence from localized receptor inactivation.
Topics: Animals; Corpus Striatum; Enkephalins; Gene Expression Regulation; Male; Naltrexone; Protein Precursors; Rats; Rats, Inbred Strains; Receptors, Opioid; RNA, Messenger | 1988 |
Opioid receptors are coupled tightly to G proteins but loosely to adenylate cyclase in NG108-15 cell membranes.
Topics: Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Cyclic AMP; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enzyme Activation; GTP Phosphohydrolases; GTP-Binding Proteins; Naltrexone; Pertussis Toxin; Protein Binding; Receptors, Opioid; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1988 |
Estimation of opioid receptor agonist dissociation constants with beta-chlornaltrexamine, an irreversible ligand which also displays agonism.
Topics: Animals; Cyclazocine; Drug Interactions; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Ethylketocyclazocine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphinans; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1988 |
Emergence and development of stress-induced analgesia and concomitant behavioral changes in mice exposed to social conflict.
Topics: Aggression; Agonistic Behavior; Animals; Arousal; Brain; Conflict, Psychological; Escape Reaction; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Naloxone; Naltrexone; Nociceptors; Receptors, Opioid; Social Environment | 1988 |
Recovery from opioid receptor alkylation: social conflict analgesia and brain [3H]etorphine binding in beta-chlornaltrexamine-treated mice.
Topics: Alkylation; Analgesia; Animals; Brain; Conflict, Psychological; Etorphine; In Vitro Techniques; Male; Mice; Mice, Inbred Strains; Naltrexone; Receptors, Opioid | 1988 |
Opiate antagonists do not alter neuronal responses to stimulation of opioid-containing pathways in rat hippocampus.
Topics: Animals; Dynorphins; Endorphins; Evoked Potentials; Hippocampus; In Vitro Techniques; Naloxone; Naltrexone; Peptide Fragments; Rats; Synaptic Transmission | 1986 |
[3H]dynorphin A binding and kappa selectivity of prodynorphin peptides in rat, guinea-pig and monkey brain.
Topics: Alkylating Agents; Animals; Benzomorphans; Brain Chemistry; Dynorphins; Guinea Pigs; In Vitro Techniques; Macaca mulatta; Morphine; Naltrexone; Peptides; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stereoisomerism | 1986 |
Effects of beta-chlornaltrexamine on food intake, body weight and opioid-induced feeding.
Topics: Animals; Body Weight; Dynorphins; Eating; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Male; Naltrexone; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid | 1987 |
Receptors for opioid peptides in the guinea-pig ileum.
Topics: Alkylation; Animals; Dose-Response Relationship, Drug; Electric Stimulation; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Ileum; Male; Mice; Naloxone; Naltrexone; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Vas Deferens | 1985 |
Synthesis and biological activity of analogues of beta-chlornaltrexamine and beta-funaltrexamine at opioid receptors.
Topics: Naltrexone; Narcotic Antagonists; Receptors, Opioid; Structure-Activity Relationship | 1986 |
Irreversible selective blockade of kappa-opioid receptors in the guinea-pig ileum.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Diuresis; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine Derivatives; Naltrexone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa | 1986 |
Bremazocine is an agonist at kappa-opioid receptors and an antagonist at mu-opioid receptors in the guinea-pig myenteric plexus.
Topics: Animals; Benzomorphans; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Morphinans; Myenteric Plexus; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1986 |
Opioid agonist and antagonist activities of monofunctional nitrogen mustard analogues of beta-chlornaltrexamine.
Topics: Animals; Chemical Phenomena; Chemistry; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Muscle Contraction; Naltrexone; Nitrogen Mustard Compounds; Receptors, Opioid; Vas Deferens | 1987 |
Diprenorphine has agonist activity at opioid kappa-receptors in the myenteric plexus of the guinea-pig ileum.
Topics: Animals; Cricetinae; Diprenorphine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphinans; Muscle Contraction; Myenteric Plexus; Naltrexone; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vas Deferens | 1987 |
Long-term analgesic reaction in attacked mice.
Topics: Aggression; Analgesia; Animals; Bites and Stings; Endorphins; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Naloxone; Naltrexone; Narcotic Antagonists | 1987 |
Opioid receptor reserve in normal and morphine-tolerant guinea pig ileum myenteric plexus.
Topics: Animals; Guinea Pigs; Humans; Male; Morphine Dependence; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Naltrexone; Receptors, Opioid | 1984 |
Preparation of brain membranes containing a single type of opioid receptor highly selective for dynorphin.
Topics: Animals; Brain Chemistry; Cell Membrane; Dynorphins; Endorphins; Guinea Pigs; Ligands; Naloxone; Naltrexone; Receptors, Opioid | 1982 |
Comparison of dynorphin-selective Kappa receptors in mouse vas deferens and guinea pig ileum. Spare receptor fraction as a determinant of potency.
Topics: Animals; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Guinea Pigs; Ileum; Male; Mice; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Receptors, Opioid; Receptors, Opioid, kappa; Structure-Activity Relationship; Vas Deferens | 1983 |
Opioid receptor selectivity of dynorphin gene products.
Topics: Animals; Dynorphins; Endorphins; Enkephalin, Leucine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Naloxone; Naltrexone; Peptide Fragments; Protein Precursors; Receptors, Opioid | 1984 |
Morphine analgesia after intrathecal administration of a narcotic agonist, chloroxymorphamine and antagonist, chlornaltrexamine.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Interactions; Hydromorphone; Injections, Spinal; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Nitrogen Mustard Compounds; Oxymorphone; Rats | 1980 |
Pharmacological studies with an alkylating narcotic agonist, chloroxymorphamine, and antagonist, chlornaltrexamine.
Topics: Analgesics; Animals; Brain; Hydromorphone; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Nitrogen Mustard Compounds; Oxymorphone | 1980 |
Isolation of selective 3H-chlornaltrexamine-bound complexes, possible opioid receptor components in brains of mice.
Topics: Animals; Brain; Chromatography, Gel; Dextrorphan; In Vitro Techniques; Mice; Naloxone; Naltrexone; Nitrogen Mustard Compounds; Receptors, Opioid | 1980 |
Demonstration of a specific dynorphin receptor in guinea pig ileum myenteric plexus.
Topics: Animals; Binding, Competitive; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalins; Guinea Pigs; Ileum; Kinetics; Muscle Contraction; Myenteric Plexus; Naltrexone; Narcotic Antagonists; Narcotics; Nitrogen Mustard Compounds; Peptide Fragments; Receptors, Opioid | 1981 |
Antagonism by chlornaltrexamine of some effects of delta 9-tetrahydrocannabinol in rats.
Topics: Analgesia; Animals; Dronabinol; Drug Tolerance; Humans; Hypothermia; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Nitrogen Mustard Compounds; Rats; Receptors, Opioid; Substance-Related Disorders | 1981 |
Irreversible inactivation of the opiate receptors in the neuroblastoma x glioma hybrid NG108-15 by chlornaltrexamine.
Topics: Animals; Cyclic AMP; Enkephalin, Methionine; Enkephalins; Glioma; Hybrid Cells; Mice; Naloxone; Naltrexone; Neoplasms, Experimental; Neuroblastoma; Nitrogen Mustard Compounds; Prostaglandins E, Synthetic; Rats; Receptors, Opioid | 1981 |
Antagonism of morphine-induced behavioral suppression by opiate receptor alkylators.
Topics: Amphetamine; Animals; Brain; Conditioning, Operant; Exploratory Behavior; Male; Morphine; Muridae; Naloxone; Naltrexone; Nitrogen Mustard Compounds; Nociceptors; Receptors, Opioid | 1982 |
Pharmacological profiles of beta-funaltrexamine (beta-FNA) and beta-chlornaltrexamine (beta-CNA) on the mouse vas deferens preparation.
Topics: Animals; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Mice; Mice, Inbred Strains; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Vas Deferens | 1982 |
Improved assays for the assessment of kappa- and delta-properties of opioid ligands.
Topics: Animals; Cyclazocine; Ethylketocyclazocine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Vas Deferens | 1982 |
Inhibition of morphine-induced analgesia and locomotor activity in strains of mice: a comparison of long-acting opiate antagonists.
Topics: Animals; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Morphine; Motor Activity; Naloxone; Naltrexone; Pain; Species Specificity | 1983 |
Use of the novel irreversible opiate antagonist, beta-chlornaltrexamine, in the estimation of the normorphine affinity constant in naive and morphine tolerant guinea-pig ilea.
Topics: Animals; Female; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Morphine Dependence; Morphine Derivatives; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists | 1983 |
Spinal antagonism of tolerance and dependence induced by systemically administered morphine.
Topics: Animals; Drug Tolerance; Humans; Male; Morphine; Morphine Dependence; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Reaction Time; Spinal Cord | 1983 |
Effects of opiate antagonists on early pregnancy and pseudopregnancy in mice.
Topics: Animals; Bromocriptine; Female; Mice; Naltrexone; Narcotic Antagonists; Pregnancy; Pregnancy, Animal; Pseudopregnancy | 1982 |
Enhancement of apomorphine-induced climbing in mice by reversible and irreversible narcotic antagonist drugs.
Topics: Animals; Apomorphine; Behavior, Animal; Drug Synergism; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Nitrogen Mustard Compounds; Time Factors | 1981 |
Body temperature, motor activity, and feeding behavior of mice treated with beta-chlornaltrexamine.
Topics: Animals; Behavior, Animal; Body Temperature; Body Weight; Circadian Rhythm; Drinking; Eating; Escherichia coli; Lipopolysaccharides; Male; Mice; Motor Activity; Naltrexone; Narcotic Antagonists; Telemetry | 1995 |
The kappa opioid receptor expressed on the mouse R1.1 thymoma cell line down-regulates without desensitizing during chronic opioid exposure.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Benzeneacetamides; Cell Membrane; Down-Regulation; In Vitro Techniques; Mice; Naloxone; Naltrexone; Pertussis Toxin; Pyrrolidines; Receptors, Opioid, kappa; Thymoma; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1995 |
The effects of protection by D-Pen2-D-Pen5-enkephalin or D-Ala2-NMePhe4-Gly-ol-enkephalin against beta-chlornaltrexamine in the spinal cord on the antinociception induced by beta-endorphin administered intracerebroventricularly in the mouse.
Topics: Amino Acid Sequence; Analgesics; Animals; beta-Endorphin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Molecular Sequence Data; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Spinal Cord | 1994 |
Relationship between kappa 1 opioid receptor binding and inhibition of adenylyl cyclase in guinea pig brain membranes.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylyl Cyclase Inhibitors; Animals; Benzeneacetamides; Binding Sites; Cerebellum; Dose-Response Relationship, Drug; Guinea Pigs; Hippocampus; Naltrexone; Pyrrolidines; Receptors, Opioid, kappa | 1993 |
Thermodynamic parameters for [D-Pen2,5]enkephalin at delta-opioid receptors in the mouse isolated vas deferens.
Topics: Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Kinetics; Male; Mice; Naltrexone; Receptors, Opioid, delta; Temperature; Thermodynamics; Vas Deferens | 1993 |
Agonist-induced functional desensitization of the mu-opioid receptor is mediated by loss of membrane receptors rather than uncoupling from G protein.
Topics: Analgesics; Animals; Binding Sites; Cell Line; Cell Membrane; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Down-Regulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; GTP-Binding Proteins; Kidney; Kinetics; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu; Sensitivity and Specificity; Stimulation, Chemical; Transfection | 1996 |
Pharmacological studies on the "orphan" opioid receptor in central and peripheral sites.
Topics: Animals; beta-Endorphin; Binding Sites; Brain; Cell Membrane; Choline; Guinea Pigs; Male; Myenteric Plexus; Naltrexone; Narcotic Antagonists; Nociceptin; Nociceptin Receptor; Opioid Peptides; Rabbits; Radioligand Assay; Rats; Receptors, Opioid; Vas Deferens | 1998 |
Effects of diethylstilbestrol on mouse hippocampal evoked potentials in vitro.
Topics: Animals; Binding, Competitive; Dactinomycin; Diethylstilbestrol; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Estrogens; Excitatory Postsynaptic Potentials; Hippocampus; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Nerve Tissue Proteins; Pyramidal Cells; Receptors, Opioid; Receptors, Opioid, mu | 1999 |
Role of agonist-dependent receptor internalization in the regulation of mu opioid receptors.
Topics: Acetylcholine; Animals; Electric Stimulation; Endocytosis; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enteric Nervous System; Guinea Pigs; Ileum; Morphine; Naltrexone; Narcotic Antagonists; Neurons; Opioid Peptides; Organ Culture Techniques; Receptors, Opioid, mu | 2000 |
Calmodulin regulation of basal and agonist-stimulated G protein coupling by the mu-opioid receptor (OP(3)) in morphine-pretreated cell.
Topics: Amino Acid Substitution; Animals; Calmodulin; Cell Line; Cell Membrane; Chickens; Egtazic Acid; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Kidney; Kinetics; Morphine; Mutagenesis, Site-Directed; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu; Recombinant Proteins; Transfection | 2000 |
Methocinnamox is a potent, long-lasting, and selective antagonist of morphine-mediated antinociception in the mouse: comparison with clocinnamox, beta-funaltrexamine, and beta-chlornaltrexamine.
Topics: Analgesics, Opioid; Animals; Binding, Competitive; Cerebral Cortex; Cinnamates; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Male; Mice; Morphine; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Pain Measurement; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2000 |
Chronic exposure to mu-opioid agonists produces constitutive activation of mu-opioid receptors in direct proportion to the efficacy of the agonist used for pretreatment.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Analgesics, Opioid; Animals; Binding Sites; Cells, Cultured; Cyclic AMP; Down-Regulation; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Receptors, Opioid, mu; Sulfur Radioisotopes; Transfection; Virulence Factors, Bordetella | 2001 |
Inverse agonists and neutral antagonists at mu opioid receptor (MOR): possible role of basal receptor signaling in narcotic dependence.
Topics: Analgesics, Opioid; Animals; Benzylidene Compounds; Cell Line; Cell Membrane; Cyclic AMP; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Kidney; Magnesium; Male; Mice; Mice, Inbred ICR; Morphine; Morphine Dependence; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Receptors, Opioid, mu; Signal Transduction; Substance Withdrawal Syndrome; Sulfur Radioisotopes; Transfection; Tritium | 2001 |
Single nucleotide polymorphisms in the human mu opioid receptor gene alter basal G protein coupling and calmodulin binding.
Topics: Calmodulin; Cells, Cultured; Cyclic AMP; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Magnesium; Morphine; Naltrexone; Polymorphism, Genetic; Receptors, Opioid, mu | 2001 |
Opioid agonists have different efficacy profiles for G protein activation, rapid desensitization, and endocytosis of mu-opioid receptors.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Electric Conductivity; Endocytosis; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; GTP-Binding Proteins; Methadone; Mice; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Neuroblastoma; Pentazocine; Pituitary Neoplasms; Receptors, Opioid, mu; Transfection; Tumor Cells, Cultured | 2003 |
Prolonged kappa opioid receptor phosphorylation mediated by G-protein receptor kinase underlies sustained analgesic tolerance.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Cell Line; Drug Tolerance; G-Protein-Coupled Receptor Kinase 3; Humans; Mice; Mice, Inbred C57BL; Mice, Knockout; Naltrexone; Phosphorylation; Protein Serine-Threonine Kinases; Receptors, Opioid, kappa | 2004 |
Alkylation of opioid receptors by 5'-naltrindole-isothiocyanate injected into the nucleus accumbens of rats: receptor selectivity and anatomical diffusion.
Topics: Alkylation; Animals; Autoradiography; Binding, Competitive; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Isothiocyanates; Male; Naltrexone; Narcotic Antagonists; Narcotics; Nucleus Accumbens; Oligopeptides; Phosphatidylethanolamines; Radioligand Assay; Rats; Rats, Inbred F344; Receptors, Opioid, delta; Transferases | 2006 |
Nitrous oxide-antinociception is mediated by opioid receptors and nitric oxide in the periaqueductal gray region of the midbrain.
Topics: Analgesics, Non-Narcotic; Animals; Dose-Response Relationship, Drug; Male; Mesencephalon; Mice; Microinjections; Naltrexone; Nitric Oxide; Nitrous Oxide; Pain Measurement; Periaqueductal Gray; Receptors, Opioid | 2008 |
Agonist-specific regulation of mu-opioid receptor desensitization and recovery from desensitization.
Topics: Analgesics, Opioid; Animals; Down-Regulation; Electrophysiology; Enkephalins; Etorphine; Fentanyl; In Vitro Techniques; Male; Naltrexone; Oxymorphone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 2008 |
Buprenorphine is a weak partial agonist that inhibits opioid receptor desensitization.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Biophysics; Brain; Brimonidine Tartrate; Buprenorphine; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Methionine; In Vitro Techniques; Male; Membrane Potentials; Mice; Mice, Transgenic; Naltrexone; Narcotic Antagonists; Narcotics; Neural Inhibition; Neurons; Patch-Clamp Techniques; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Yohimbine | 2009 |
Opioid receptor internalization contributes to dermorphin-mediated antinociception.
Topics: Analgesics, Opioid; Animals; Bicuculline; Concanavalin A; Dynamins; Fluorescent Dyes; GABA-A Receptor Antagonists; Male; Microinjections; Naltrexone; Neurons; Opioid Peptides; Pain; Pain Measurement; Peptides; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 2010 |
Tolerance to the antinociceptive effect of morphine in the absence of short-term presynaptic desensitization in rat periaqueductal gray neurons.
Topics: Analgesics; Animals; Drug Tolerance; Electrophysiological Phenomena; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Inhibitory Postsynaptic Potentials; Male; Morphine; Naltrexone; Neurons; Pain Measurement; Patch-Clamp Techniques; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid, mu; Signal Transduction | 2010 |
Desensitization of functional µ-opioid receptors increases agonist off-rate.
Topics: Analgesics, Opioid; Animals; Brain; Enkephalins; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Kinetics; Ligands; Naloxone; Naltrexone; Photolysis; Potassium; Rats; Receptors, Opioid, mu | 2014 |
Effects of atomoxetine on attention and impulsivity in the five-choice serial reaction time task in rats with lesions of dorsal noradrenergic ascending bundle.
Topics: Adrenergic Agents; Adrenergic Uptake Inhibitors; Afferent Pathways; Animals; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Benzylamines; Brain; Brain Injuries; Choice Behavior; Impulsive Behavior; Male; Microdialysis; Naltrexone; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Propylamines; Rats; Rats, Sprague-Dawley; Reaction Time; Zimeldine | 2015 |