naltrexone has been researched along with beta-funaltrexamine in 517 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 100 (19.34) | 18.7374 |
| 1990's | 217 (41.97) | 18.2507 |
| 2000's | 140 (27.08) | 29.6817 |
| 2010's | 56 (10.83) | 24.3611 |
| 2020's | 4 (0.77) | 2.80 |
| Authors | Studies |
|---|---|
| Fries, DS; Larson, DL; Portoghese, PS; Sayre, LM; Takemori, AE | 1 |
| Bell, GI; Chen, Y; Kong, H; Raynor, K; Reisine, T; Yasuda, K; Yu, L | 1 |
| Adapa, ID; Auh, JS; Berzetei-Gurske, IP; Brandt, SR; Craymer, K; Farrington, L; Haggart, D; Kennedy, JM; O'Brien, A; Polgar, WE; Rodriguez, L; Schwartz, RW; Toll, L; White, A | 1 |
| Aschenbach, LC; Cassidy, MP; Chen, J; Dewey, WL; Gabra, BH; Li, G; Selley, DE; Stevens, DL; Westkaemper, RB; Zhang, Y | 1 |
| Aschenbach, LC; He, H; Li, G; Selley, DE; Zhang, Y | 1 |
| Iwata, S; Koyama, Y; Kutsumura, N; Miyata, Y; Nagase, H; Nagumo, Y; Nakajima, R; Saitoh, T; Yamamoto, N; Yoshida, N | 1 |
| al-Rodhan, NR; Kelly, PJ; Yaksh, TL | 1 |
| Kameyama, T; Toyoshi, T; Ukai, M | 5 |
| Robinson, SR; Smotherman, WP | 1 |
| Holtzman, SG; Jones, DN | 1 |
| Kamei, J; Kasuya, Y; Kawashima, N; Ohhashi, Y | 1 |
| Tang, RR; Tseng, LF | 1 |
| Pasternak, GW; Paul, D; Pick, CG | 2 |
| Blackford, SP; Kuhn, CM; Little, PJ | 1 |
| Cometta-Morini, C; Kamal, J; Loew, G; Maguire, P; Tsai, N; Upton, C | 1 |
| Franklin, TG; Traynor, JR | 1 |
| Larson, AA; Mousseau, DD; Sun, X | 1 |
| Ho, IK; Hoskins, B; Jaw, SP; Makimura, M; Oh, KW | 1 |
| Lewis, ME; Li, SX; Liu-Chen, LY | 1 |
| Misawa, M; Nagase, H; Narita, M; Suzuki, T | 3 |
| de Costa, BR; Horan, P; Porreca, F; Rice, KC | 1 |
| Chalmers, J; Drolet, G; Morilak, DA | 2 |
| Adamson, WT; Blackford, S; Kuhn, CM; Windh, RT | 1 |
| Mjanger, E; Yaksh, TL | 1 |
| Bykov, V; de Costa, BR; Holaday, JW; Jacobson, AE; Jiang, Q; Long, JB; Mahboubi, A; Porreca, F; Rice, KC; Rothman, RB | 1 |
| Jang, Y; Yoburn, BC | 1 |
| Collins, JG; Kitahata, LM; Nakatani, K; Omote, K | 1 |
| Portoghese, PS; Sofuoglu, M; Takemori, AE | 2 |
| Arjune, D; Bodnar, RJ; Bowen, WD | 1 |
| Billington, CJ; Grace, M; Levine, AS | 1 |
| Lu, CL; Shaikh, MB; Siegel, A | 1 |
| Cowan, A; Li, SX; Liu-Chen, LY; Wheeler-Aceto, H | 1 |
| Baumann, MH; Rabii, J | 1 |
| Butler, B; Gunion, MW; Miller, S; Moore, RD; Morley, JE; Rosenthal, MJ; Zib, B | 1 |
| Shiotsu, G; Stein, L; Stevens, KE | 1 |
| Barnes, MI; Hong, JS; Hudson, PM; Mitchell, CL | 1 |
| Duckles, SP; Li, YJ | 1 |
| Fischbach, PS; McCleskey, EW; Schroeder, JE; Zheng, D | 1 |
| Cappell, H; Lê, AD; Poulos, CX; Walker, MJ | 1 |
| Giordano, J; Hughes, RA; Sufka, KJ | 1 |
| Jacoby, HI; Martinez, RP; Raffa, RB; Schupsky, JJ | 1 |
| Arjune, D; Bodnar, RJ; Pasternak, GW; Standifer, KM | 1 |
| Bykov, V; Holaday, JW; Jacobson, AE; Long, JB; Rice, KC; Rothman, RB | 2 |
| Carlsson, S; Hoffmann, P; Thorén, P | 1 |
| Hoffmann, P; Skarphedinsson, JO; Thorén, P | 1 |
| Abbott, FV | 1 |
| Chen, DC; Quock, RM | 1 |
| Dixon, DM; Traynor, JR | 1 |
| Li, SX; Liu-Chen, LY; Tallarida, RJ | 1 |
| Holowecky, O; Li, S; Liu-Chen, LY; Tallarida, RJ | 1 |
| Lewis, ME; Li, SX; Liu-Chen, LY; Rohrbach, KW | 1 |
| Bodnar, RJ; Islam, AK | 1 |
| Heyman, JS; Koslo, RJ; Porreca, F; Qi, JA; Sheldon, RJ | 1 |
| Best, JA; Chen, DC; Portoghese, PS; Quock, RM; Takemori, AE; Vaughn, LK | 1 |
| Suh, HH; Tseng, LF | 2 |
| Davenport, KE; Houdi, AA; Van Loon, GR | 1 |
| Fuentes, JA; Iglesias, T; Jiménez, I | 1 |
| Mosberg, HI; Porreca, F; Qi, JA | 1 |
| Balfour, HH; Gekker, G; Peterson, PK; Portoghese, PS; Sannerud, K; Sharp, BM | 1 |
| Adams, JU; Holtzman, SG; Paronis, CA | 1 |
| Delle, M; Hoffmann, P; Thorén, P | 1 |
| Cowan, A; Murray, CW | 1 |
| Cherubini, E; North, RA; Tokimasa, T | 1 |
| Bronson, ME; Sparber, SB | 1 |
| Brady, LS; Bykov, V; Holaday, JW; Jacobson, AE; Long, JB; Rice, KC; Rothman, RB | 1 |
| Kavaliers, M | 2 |
| Dickenson, AH; Roques, BP; Sullivan, AF | 1 |
| Heyman, JS; Jiang, Q; Mosberg, HI; Porreca, F; Rothman, RB | 1 |
| Heyman, JS; Jiang, Q; Porreca, F | 1 |
| Garzón, J; Sánchez-Blázquez, P | 2 |
| Huidobro-Toro, JP; Li, CH; Valenzuela, R | 1 |
| Fujimoto, JM; Rady, JJ | 1 |
| Pasternak, GW; Recht, LD | 1 |
| Portoghese, PS; Takemori, AE | 4 |
| Liu-Chen, LY; Phillips, CA | 1 |
| Leander, JD | 3 |
| Heyman, JS; Mosberg, HI; Mulvaney, SA; Porreca, F | 1 |
| Kunos, G; Mosqueda-Garcia, R | 1 |
| Adams, JU; Andrews, JS; Hiller, JM; Holtzman, SG; Simon, EJ | 1 |
| Smith, CB | 1 |
| DeLander, GE; Portoghese, PS; Takemori, AE | 2 |
| Herz, A; Höllt, V; Morris, BJ | 1 |
| Holtzman, SG; Ukai, M | 1 |
| Portoghese, PS; Schwartz, MM; Takemori, AE | 1 |
| Dykstra, LA; Negus, SS | 1 |
| Hayes, AG; Sheehan, MJ; Tyers, MB | 2 |
| Di Chiara, G; Imperato, A | 1 |
| Bloom, FE; Chavkin, C; Henriksen, SJ; Siggins, GR | 1 |
| Hayes, AG; Skingle, M; Tyers, MB | 4 |
| Laorden, ML; Miralles, FS; Puig, MM | 1 |
| Fujimoto, JM; Roerig, SC; Tseng, LF | 1 |
| Koenig, JI; Krulich, L; Moss, RL; Wiesner, JB | 1 |
| Fries, DS; Larson, DL; Portoghese, PS; Takemori, AE; Ward, SJ | 1 |
| Dray, A; Nunan, L; Wire, W | 1 |
| Eisenberg, RM | 3 |
| Holaday, JW; Robles, L; Tortella, FC | 1 |
| Corbett, AD; Kostelitz, HW; McKnight, AT; Paterson, SJ; Robson, LE | 1 |
| Hayes, AG; Stewart, BR | 1 |
| Gallagher, M | 1 |
| Liu-Chen, LY; Nickolson, VJ; Tam, SW | 1 |
| James, DW; LoPresti, D; Ward, SJ | 1 |
| Larson, DL; Mohamed, MS; Portoghese, PS; Takemori, AE | 1 |
| Holtzman, SG; Locke, KW | 2 |
| McLaughlin, PJ; Zagon, IS | 1 |
| Portoghese, PS; Rein, MD; Takemori, AE | 1 |
| Portoghese, PS; Schoenecker, JW; Takemori, AE | 1 |
| Liu-Chen, LY; Tam, SW | 1 |
| Clark, MJ; Levenson, SD; Medzihradsky, F | 1 |
| Corbett, AD; Kosterlitz, HW | 1 |
| Mosberg, HI; Robles, L; Tortella, FC | 1 |
| Hynes, MD; Leander, JD; Reel, JK; Zimmerman, DM | 1 |
| Corbett, AD; Kosterlitz, HW; Traynor, JR | 1 |
| France, CP; Woods, JH | 2 |
| Birch, PJ; Hayes, AG | 1 |
| Dykstra, LA; Gmerek, DE; Winger, G; Woods, JH | 1 |
| Portoghese, PS; Takahashi, M; Takemori, AE | 1 |
| Heyman, JS; Porreca, F | 1 |
| Griffin, JF; Larson, DL; Portoghese, PS | 1 |
| Aceto, MD; Dewey, WL; Portoghese, PS; Takemori, AE | 1 |
| Dykstra, LA | 1 |
| McLaughlin, PJ; Portoghese, PS; Takemori, AE; Zagon, IS | 1 |
| Gmerek, DE; Woods, JH | 1 |
| Pert, CB; Rothman, RB; Schumacher, UK | 1 |
| North, RA; Williams, JT | 1 |
| Holaday, JW; Tortella, FC | 1 |
| Bennett-Kelly, L; Smith, CB; Woods, JH | 1 |
| Corbett, AD; Kosterlitz, HW; McKnight, AT; Paterson, SJ | 1 |
| Portoghese, PS; Takemori, AE; Ward, SJ | 3 |
| Huidobro-Toro, JP; Way, EL; Yoshimura, K | 1 |
| Takemori, AE; Ward, SJ | 3 |
| Herz, A; Schulz, R; Wüster, M | 1 |
| Hylden, JL; Wilcox, GL | 1 |
| Larson, DL; Portoghese, PS; Takemori, AE | 1 |
| Messing, RB; Portoghese, PS; Sparber, SB; Takemori, AE | 1 |
| Belenky, GL; Gelinas-Sorell, D; Holaday, JW; Kenner, JR | 1 |
| D'Amato, RJ; Holaday, JW | 1 |
| Bowen, WD; Pert, CB; Rothman, RB; Schumacher, UK | 1 |
| Cowan, A; Holaday, JW; Robles, LE; Tortella, FC | 1 |
| D'Amato, R; Holaday, JW | 1 |
| Koenig, JI; Krulich, L; Mayfield, MA; McCann, SM | 1 |
| Gmerek, D; Woods, JH | 1 |
| Frischknecht, HR; Riggio, G; Siegfried, B; Waser, PG | 1 |
| Berzetei-Gurske, IP; DeCosta, BR; Pasternak, GW; Polgar, W; Toll, L; White, A | 1 |
| Fukuda, K; Fukushima, N; Misu, Y; Miyamae, T; Sasaki, Y; Takeshima, H; Ueda, H | 1 |
| Armstead, WM | 2 |
| Imai, Y; Schäfer, M; Stein, C; Uhl, GR | 1 |
| Fujinami, T; Nishimura, M; Saeki, T; Sato, N; Watanabe, Y | 1 |
| Gong, QZ; Hamm, RJ; Jiang, JY; Lyeth, BG; Young, HF | 1 |
| Bodnar, RJ; Cole, JL; Kirkham, TC; Leventhal, L | 1 |
| Endoh, T; Misawa, M; Mori, T; Nagase, H; Suzuki, T; Tsuji, M | 1 |
| Bodnar, RJ; Bowen, WD; Cole, JL; Leventhal, L; Pasternak, GW | 1 |
| Chen, C; Chen, YW; Kim de Riel, J; Kunapuli, S; Liu-Chen, LY; Xue, JC; Yu, L; Zhu, J | 1 |
| Iwamoto, Y; Kamei, J; Kasuya, Y; Misawa, M; Nagase, H; Ohsawa, M; Saitoh, A; Suzuki, T | 1 |
| Bodnar, RJ; Cooper, ML; Glass, MJ; Koch, JE | 1 |
| Bodnar, RJ; Glass, MJ; Koch, JE | 1 |
| Randić, M; Wang, RA | 1 |
| Carr, DJ; Garza, HH; Prakash, O | 1 |
| Noble, F; Roques, BP | 1 |
| Kamei, J; Kasuya, Y; Misawa, M; Nagase, H; Suzuki, T | 1 |
| Carpenter, GW; Carr, DJ | 1 |
| Adams, JU; Li, S; Liu-Chen, LY; Yang, HH | 1 |
| Coderre, TJ; Henry, JL; Pitcher, GM; Yashpal, K | 1 |
| Kamei, J; Kasuya, Y; Misawa, M; Nagase, H; Ohsawa, M | 2 |
| Elliott, J; Lambert, DG; Smart, D; Traynor, JR | 2 |
| Bodnar, RJ; Glass, MJ; Hahn, B; Joseph, A | 1 |
| Dhawan, KN; Gupta, MB; Nath, C; Patnaik, GK | 1 |
| Hitosugi, H; Kamei, J; Kasuya, Y; Misawa, M; Nagase, H | 1 |
| Dykstra, LA; Mattox, AJ; Picker, MJ | 1 |
| Broadbear, JH; Butelman, ER; de Costa, BR; Negus, SS; Woods, JH | 1 |
| Dworkin, SI; Martin, TJ; Smith, JE | 2 |
| Ingenito, AJ; Wong, SC | 1 |
| Búzás, B; Cox, BM; Izenwasser, S | 1 |
| Fujimoto, JM; Holmes, BB | 1 |
| Devine, DP; Leone, P; Wise, RA | 1 |
| Connelly, CD; Martinez, RP; Porreca, F; Raffa, RB; Schupsky, JJ | 1 |
| Isaac, L; Ristic, H | 1 |
| Macdonald, RL; Moises, HC; Rusin, KI | 1 |
| Kishioka, S; Masuda, Y; Miyamoto, Y; Ozaki, M; Yamamoto, H | 1 |
| Kameyama, T; Mizutani, M; Ukai, M | 1 |
| Kameyama, T; Mizutani, M; Sasaki, Y; Toyoshi, T; Ukai, M | 1 |
| Kwok, YN; McIntosh, C; Yago, V | 1 |
| Iwamoto, Y; Kamei, J; Kasuya, Y; Misawa, M; Nagase, H; Suzuki, T | 1 |
| Dykstra, LA; Pitts, RC | 1 |
| Hitosugi, H; Iwamoto, Y; Kamei, J; Kasuya, Y; Misawa, M; Nagase, H | 1 |
| Iwamoto, Y; Kamei, J; Kasuya, Y; Misawa, M; Nagase, H | 2 |
| Callahan, P; Janik, J; Klosterman, S; Parman, R | 1 |
| Randich, A; Robertson, JD; Willingham, T | 1 |
| Cai, YP; Yu, LC | 1 |
| Chow, S; Lê, AD; Poulos, CX; Quan, B | 1 |
| Billington, CJ; Grace, MK; Kotz, CM; Levine, AS | 1 |
| Iwamoto, Y; Kamei, J; Kasuya, Y; Misawa, M; Mizuno, D; Nagase, H; Okutomi, T; Soma, G; Suzuki, T | 1 |
| Bodnar, RJ; Hahn, B; Koch, JE; Ruegg, H | 1 |
| Lendvai, B; Sándor, A; Sándor, NT | 1 |
| Billington, CJ; Grace, M; Levine, AS; Portoghese, PS | 1 |
| Kapusta, DR; Obih, JC | 1 |
| Chen, C; Liu-Chen, LY; Phillips, CA | 1 |
| Hua, M; Larson, DL; Portoghese, PS; Takemori, AE | 1 |
| Bodnar, RJ; Kiefel, JM; Rossi, GC | 1 |
| Innes, DG; Kavaliers, M | 1 |
| Holtzman, SG; Paronis, CA; Waddell, AB | 1 |
| Funada, M; Misawa, M; Nagase, H; Narita, M; Suzuki, T | 1 |
| Miyamoto, Y; Takemori, AE | 1 |
| Ho, IK; Hoskins, B; Jaw, SP | 1 |
| Bodnar, RJ; Koch, JE | 1 |
| Nejat, RJ; Pasternak, GW; Pick, CG | 1 |
| Henriksen, SJ; Koob, GF; Mattox, A; Negus, SS; Pasternak, GW; Portoghese, PS; Takemori, AE; Weinger, MB | 1 |
| Plotsky, PM; Rivest, S; Rivier, C | 1 |
| Chuluyan, HE; Saphier, D; Welch, JE | 1 |
| Bonavera, JJ; Kalra, PS; Kalra, SP | 1 |
| Funada, M; Misawa, M; Nagase, H; Narita, M; Suzuki, T; Takahashi, Y; Takamori, K | 1 |
| Baumhaker, Y; Gafni, M; Keren, O; Sarne, Y | 1 |
| Beczkowska, IW; Bodnar, RJ; Bostock, ME; Koch, JE; Leibowitz, SF | 1 |
| Callahan, P; Janik, J; Kehoe, L; Parman, R | 1 |
| de Cabo, C; Kelly, M; Kitchen, I; Viveros, MP | 1 |
| Koob, GF; Negus, SS; Pasternak, GW; Weinger, MB | 1 |
| Misawa, M; Mori, T; Nagase, H; Suzuki, T; Tsuji, M | 1 |
| Hansson, P; Lundeberg, T; Yu, LC | 1 |
| Bodnar, RJ; Cooper, ML; Glass, MJ; Ragnauth, A | 1 |
| Cowan, A; Hunter, JC; Kovelowski, CJ; Lai, J; Malan, TP; Ossipov, MH; Porreca, F; Wheeler-Aceto, H | 1 |
| Bofetiado, DM; D'Alecy, LG; Mayfield, KP | 1 |
| Chen, C; DesJarlais, RL; Liu-Chen, LY; Raveglia, LF; Riel, JK; Yin, J; Zhu, J | 1 |
| Chao, CC; Gekker, G; Hu, S; Molitor, TW; Peterson, PK; Sheng, WS | 1 |
| Davenport, KE; Houdi, AA; Marson, L; Van Loon, GR | 1 |
| Gouardères, C; Jhamandas, K; Sutak, M; Zajac, JM | 1 |
| Gergen, KA; Kastin, AJ; Paul, D; Zadina, JE | 1 |
| Carino, MA; Guy, AW; Horita, A; Lai, H | 1 |
| Bodnar, RJ; Cole, JL; Leventhal, L | 1 |
| Ahtee, L; Piepponen, TP | 1 |
| Besson, JM; Buritova, J; Honoré, P | 1 |
| Baumann, MH; Callahan, P; Rabii, J | 1 |
| Holtzman, SG; Justice, JB; Schad, CA | 1 |
| Broadbear, J; Derrick, I; Lewis, JW; Moynihan, HA; Woods, JH | 1 |
| Adler, MW; Chen, XH; de Riel, JK; Geller, EB; Liu-Chen, LY; Tallarida, RJ | 1 |
| Kovacević-Jovanović, V; Mancev, Z; Pesić, G; Radulović, J; Stanojević, S; Vasiljević, T | 1 |
| Kameyama, T; Kobayashi, T; Mori, K; Sasaki, Y; Shinkai, N; Ukai, M | 1 |
| Bodnar, RJ; Leventhal, L | 1 |
| Fuentes, JA; Reche, I; Ruiz-Gayo, M | 1 |
| Fournié-Zaluski, MC; Fuentes, JA; Hernando, F; Roques, BP; Ruiz-Gayo, M | 1 |
| Ho, ST; Lee, SC; Tao, PL; Wang, JJ | 1 |
| Chao, CC; Gekker, G; Hu, S; Lipovsky, MM; Molitor, TW; Peterson, PK; Sowa, G | 1 |
| Briski, KP | 1 |
| Freeman, J; Gent, JP; Goodchild, CS; Guo, Z | 1 |
| Kamei, J; Nagase, H; Sodeyama, M; Suzuki, T; Tsuda, M | 1 |
| Holtzman, SG | 2 |
| Burke, TF; Garner, HR; Lawhorn, CD; Stoner, JM; Wessinger, WD | 1 |
| Bodnar, RJ; Leventhal, L; Pasternak, GW; Rossi, GC; Stevens, LB | 1 |
| Bertolucci, M; De Simoni, MG; Perego, C | 1 |
| Childers, SR; deMontis, MG; Martin, TJ; Selley, DE; Sim, LJ | 1 |
| Bodnar, RJ; Ragnauth, A; Ruegg, H | 1 |
| Kameyama, T; Monma, J; Sasaki, Y; Shinkai, N; Ukai, M | 1 |
| Picker, MJ | 1 |
| Higashiyama, K; Kamei, J; Kubo, H; Li, J; Nagase, H; Ohmiya, S; Ohsawa, M; Takahashi, H; Xiao, P | 1 |
| Froehlich, JC; Krishnan-Sarin, S; Li, XW; Portoghese, PS; Wand, GS | 1 |
| He, Z; Ho, IK; Tsang, BK; Wongchanapai, W | 1 |
| Gross, GJ; Hsu, AK; Schultz, JE | 1 |
| Casale, M; O'Brien, CP; Stromberg, MF; Volpicelli, JR; Volpicelli, L | 1 |
| Hansson, P; Löfgren, O; Lundeberg, T; Theodorsson, E; Yu, LC | 1 |
| Agmo, A; Belzung, C | 1 |
| Kizawa, Y; Koike, K; Okayasu, A; Suzuki, T; Takayanagi, I | 1 |
| Matsuzawa, S; Misawa, M; Nagase, H; Suzuki, T | 3 |
| Carino, M; Lai, H | 1 |
| DeMontis, MG; Dworkin, SI; Kim, SA; Martin, TJ; Sizemore, GM; Smith, JE | 1 |
| Kameyama, T; Shinkai, N; Ukai, M | 1 |
| Morgan, D; Picker, MJ | 1 |
| Pol, O; Puig, MM | 1 |
| Adler, MW; Geller, EB; Handler, CM; Price, RW | 1 |
| Fujimoto, JM; Gorny, JM; Rady, JJ | 1 |
| Abood, ME; Aceto, MD; Harris, LS; Rice, KC | 1 |
| Arcaya, JL; Cano, G; Gómez, G; Maixner, W; Suárez-Roca, H | 1 |
| Chang, JK; Dun, NJ; Dun, SL; Wright, MT; Wu, SY | 1 |
| Newman, LC; Stevens, CW | 1 |
| Kowalski, J | 1 |
| Goto, K; Ishige, A; Komatsu, Y; Omiya, Y; Suzuki, Y | 1 |
| Fujimura, T; Kastin, AJ; Katsuyama, S; Murayama, K; Sakurada, S; Sakurada, T; Ueda, H; Yuki, M; Zadina, JE | 1 |
| Benyas, SI; Dykstra, LA; Picker, MJ; Tiano, MJ; Walker, EA | 1 |
| Besson, JM; Catheline, G; Fournié-Zaluski, MC; Honoré, P; Le Guen, S; Roques, BP | 1 |
| Briski, KP; Teodecki, L | 1 |
| Frankel, PS; Garcia, MM; Harlan, RE | 2 |
| Chu, XP; Li, P; Wang, JQ; Xu, NS | 1 |
| Fujii, T; Goto, T; Motoyama, Y; Ochi, T | 1 |
| Lundeberg, T; Yu, LC; Zhang, YP | 1 |
| Cui, RY; Jiang, CL; Liu, XY; Lu, CL; Son, LX; Sun, LY; Wang, YX; You, ZD | 1 |
| Kamei, J; Nagase, H; Ohsawa, M; Zushida, K | 1 |
| Becker, A; Höllt, V; Krug, M; Loh, H; Matthies, H; Schroeder, H | 1 |
| Hellstrand, K; Hoffmann, P; Jonsdottir, IH; Thorén, P | 1 |
| Esashi, A; Kisara, K; Nakagawasai, O; Niijima, F; Sakurada, S; Tadano, T; Takahashi, N; Tan-No, K; Yonezawa, A | 1 |
| Calvo, R; Garrido, MJ; Pavón, JM; Trocóniz, IF; Valle, M | 1 |
| Hayashi, T; Kisara, K; Kutsuwa, M; Sakurada, C; Sakurada, S; Sakurada, T; Sato, T; Takeda, S; Tan-No, K; Yuki, M | 1 |
| Misawa, M; Mizoguchi, H; Nagase, H; Narita, M; Suzuki, T; Takahashi-Nakano, Y; Tseng, LF; Yajima, Y | 1 |
| Freeman, FM; Young, IG | 1 |
| Baumer, F; Bodnar, RJ; Pasternak, GW; Rossi, GC; Stein, JA; Znamensky, V | 1 |
| Kameyama, T; Ukai, M; Watanabe, Y | 2 |
| Newman, LC; Stevens, CW; Wallace, DR | 1 |
| El Kouhen, R; Law, PY; Le Bourdonnec, B; Loh, HH; Lunzer, MM; Portoghese, PS | 1 |
| Hirohashi, M; Kitano, Y; Komiyama, C; Makino, M; Takasuna, K | 1 |
| Altememi, GF; Mandyam, CD; Standifer, KM | 1 |
| Arai, K; Furuta, S; Hayashi, T; Katsuyama, S; Kisara, K; Miyazaki, S; Onodera, K; Sakurada, S; Sato, T; Yonezawa, A | 1 |
| Broadbear, JH; Burke, TF; Husbands, SM; Lewis, JW; Sumpter, TL; Traynor, JR; Woods, JH | 1 |
| Cox, E; Danhof, M; Garrido, M; Gubbens-Stibbe, J; IJzerman, A; Künzel, D; Tukker, E; van der Graaf, PH; von Frijtag, J | 1 |
| Hales, TG; Law, PY; Piros, ET; Prather, PL; Song, L | 1 |
| Kuzmin, A; Ogren, SO; Sandin, J; Terenius, L | 1 |
| Mizoguchi, H; Nagase, H; Narita, M; Tseng, LF | 1 |
| Chao, CC; Hegg, CC; Hu, S; Peterson, PK; Thayer, S | 1 |
| Pol, O; Puig, MM; Valle, L | 1 |
| Oliveira, MA; Prado, WA | 1 |
| Bergman, J; Carey, GJ | 1 |
| Campbell, VC; Welch, SP | 1 |
| Bodnar, RJ; Hadjimarkou, MM; Pasternak, GW; Rossi, GC; Silva, RM | 1 |
| Neilan, CL; Nguyen, TM; Pasternak, GW; Schiller, PW | 1 |
| Alt, A; Fan, CD; McFadyen, IJ; Traynor, JR; Woods, JH | 1 |
| Bodnar, RJ; Christian, G; Echo, JA; Lamonte, N; Ragnauth, A; Znamensky, V | 1 |
| Burgess, SE; Gardell, LR; Lai, J; Lappi, DA; Malan, TP; Ossipov, MH; Porreca, F; Vanderah, TW | 1 |
| Ioka, M; Mizoguchi, H; Nagase, H; Narita, M; Ozaki, S; Suzuki, T; Tseng, LF | 1 |
| Liu, JG; Prather, PL; Ruckle, MB | 1 |
| Gumułka, SW; Lipkowski, AW; Makulska-Nowak, HE; Rawa, MA | 1 |
| Konopińska, D; Plech, A; Rykaczewska-Czerwińska, M | 1 |
| Katoh, T; Mamiya, T; Ukai, M | 1 |
| Agarwal, SS; Dhar, MM; Haq, W; Narayan, P; Raghubir, R; Singh, VK; Tandon, R | 1 |
| Ackerman, TF; Bodnar, RJ; Christian, G; Echo, JA; Lamonte, N | 1 |
| Bodnar, RJ; Grossman, HC; Hadjimarkou, MM; Pasternak, GW; Rossi, GC; Silva, RM | 1 |
| Kim, SA; Lyupina, Y; Martin, TJ; Smith, JE | 1 |
| Li, JJ; Li, Y; Yu, LC | 1 |
| Gabriel, A; Grond, S; Huang, YH; Lu, JT; Meuser, T; Pierce Palmer, P; Pietruck, C; Yu, LC | 1 |
| Imai, S; Itou, Y; Narita, M; Suzuki, T; Yajima, Y | 1 |
| Bardo, MT; Gehrke, BJ; Phillips, SB; Rauhut, AS | 1 |
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| Dimitrijević, M; Kovacević-Jovanović, V; Radulović, J; Stanojević, S; Vujić, V | 1 |
| Chawda, RP; Mahajan, SD; Nair, MP; Schwartz, SA; Shanahan, TC | 1 |
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| Bardo, MT; Gehrke, BJ; Rauhut, AS; Shortridge, BE | 1 |
| Hu, DY; Kai, L; Liu, LM; Shi, YL; Wang, ZF | 2 |
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| Cousins, MJ; Fink, DJ; Hao, S; Iwasaki, H; Mamiya, K; Mata, M; Takahata, O | 1 |
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| Martin, TJ; Roberts, DC; Ward, SJ | 1 |
| Choi, SS; Han, EJ; Han, KJ; Lee, HK; Suh, HW | 1 |
| Okuda, A; Ukai, M | 1 |
| Lundeberg, T; Yu, LC; Yu, SQ | 1 |
| Douglas, SD; Ho, WZ; Lai, JP; Li, Y; Pleasure, DE; Xiao, WD; Zhang, T | 1 |
| Barrington, PL; Ellenberger, EA; Lucas, HL; Mueller, JL; Quock, RM; Russo, JM; Tseng, LF | 1 |
| Honda, T; Nagase, H; Nakao, K; Okano, K; Tanaka, T; Togashi, Y; Umeuchi, H | 1 |
| Brailoiu, GC; Dun, NJ; Ohtubo, Y; Wu, SY | 1 |
| Bodnar, RJ; Giraudo, SQ; Grossman, HC; Hadjimarkou, MM; Silva, RM | 1 |
| Koseki, M; Matsumura, E; Sakaguchi, M; Wakamatsu, M | 2 |
| Bourgoin, S; Glowinski, J; Godeheu, G; Jabourian, M; Kemel, ML; Pérez, S | 1 |
| Carrigan, KA; Elliott, JC; Lysle, DT; Nelson, CJ; Picker, MJ | 1 |
| Gao, HM; Liu, H; Song, HS; Tang, YY; Zhang, WQ | 1 |
| Beglan, CL; Spivak, CE | 1 |
| Barea-Rodriguez, E; Harvey, SA; Martinez, JL; Meilandt, WJ | 1 |
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| Gao, L; Yu, LC | 1 |
| Clithero, AD; Leitermann, RJ; MacDougall, RS; Terashvili, M; Tseng, LF; Wu, HE | 1 |
| Aloisi, AM; Ceccarelli, I; Fiorenzani, P; Grasso, G; Lariviere, WR; Massafra, C; Massai, L; Muscettola, M | 1 |
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| Fujimura, T; Ito, K; Kawamura, S; Mizoguchi, H; Murayama, K; Nakayama, D; Sakurada, C; Sakurada, S; Sakurada, T; Sato, T; Watanabe, C; Watanabe, H | 1 |
| Ambo, A; Bryant, SD; Fujita, Y; Jinsmaa, Y; Lazarus, LH; Li, T; Miyazaki, A; Okada, Y; Sasaki, Y; Shiotani, K; Tsuda, Y | 1 |
| Aso, E; Balerio, GN; Maldonado, R | 1 |
| Bourgoin, S; Glowinski, J; Godeheu, G; Jabourian, M; Kemel, ML; Ozon, S; Pérez, S; Venance, L | 1 |
| Ammon-Treiber, S; Höllt, V; Loh, H; Schröder, H; Stolze, D | 1 |
| Chi, YM; Hashimoto, F; Kinjo, J; Nakamura, M; Nohara, T; Sakurada, S; Yan, WM; Yoshizawa, T; Zhao, XY | 1 |
| Kamei, J; Nozaki, C; Saitoh, A; Tamura, N | 1 |
| Aburada, M; Kase, Y; Murata, M; Omiya, Y; Suzuki, Y; Takeda, S; Yuzurihara, M | 1 |
| Farrell, PA; Loomis, JL; Rodd, DW | 1 |
| Fan, GX; Tang, JS; Wang, JY; Yuan, YK; Zeng, XY | 1 |
| Xiong, W; Yu, LC | 1 |
| Kamei, J; Nozaki, C; Saitoh, A | 1 |
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| Kong, LL; Yu, LC | 1 |
| Chugh, C; Jain, H; Mediratta, PK; Rathi, N; Reeta, Kh; Sharma, KK | 1 |
| Ambo, A; Bryant, SD; Fujita, Y; Jinsmaa, Y; Lazarus, LH; Li, T; Marczak, E; Miyazaki, A; Okada, Y; Sasaki, Y; Shiotani, K; Tsuda, Y | 1 |
| Bagosi, Z; Bujdosó, E; Jászberényi, M; Szabó, G; Telegdy, G | 1 |
| Simansky, KJ; Ward, HG | 1 |
| Hatori, Y; Horie, S; Kitajima, M; Matsumoto, K; Misawa, K; Murayama, T; Takayama, H; Tashima, K; Wongseripipatana, S | 1 |
| Gu, XL; Yu, LC | 1 |
| Mascagni, F; McDonald, AJ; Primeaux, SD; Wilson, MA; Wilson, SP | 1 |
| Kamei, J; Nozaki, C | 1 |
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| Buck, DJ; Davis, RL; Saffarian, N; Stevens, CW | 1 |
| Deng, C; Huang, XF; South, T | 1 |
| Gintzler, AR; Liu, NJ; von Gizycki, H | 1 |
| Co, C; Coller, M; Martin, TJ; Smith, JE | 1 |
| Andoh, T; Kuraishi, Y; Nakashima, Y; Sasaki, A; Shiraki, K; Takasaki, I | 1 |
| Gu, XL; Sun, YG; Yu, LC | 1 |
| Honda, T; Katsura, M; Ohkuma, S; Shibasaki, M; Sumimoto, A; Torigoe, F; Tsujimura, A | 1 |
| Ho, WZ; Li, Y; Luo, GX; Peng, JS; Wan, Q; Wang, CQ; Ye, L; Zhang, T | 1 |
| Fossum, EN; Ingram, SL; Macey, TA; Morgan, MM | 1 |
| Garcia, MM; Guo, N; Harlan, RE; Taylor, BK; Zadina, JE | 1 |
| Dimitrijević, M; Kovacević-Jovanović, V; Kustrimović, N; Miletić, T; Mitić, K; Stanojević, S; Vujić, V | 1 |
| Chen, Q; Dong, L; Fu, CY; Ni, JM; Wang, R; Zhao, YL | 1 |
| Buck, DJ; Davis, RL; DeSilva, U; Fernando, SC; Mohan, S; Saffarian, N; Stevens, CW | 1 |
| Huang, FS; Tang, JS; Wang, JY; Yuan, YK; Zhao, M | 1 |
| Bidlack, JM; Fulton, BS; Mathews, JL; Negus, SS; Neumeyer, JL | 1 |
| Komatsu, T; Mizoguchi, H; Morimoto, M; Sakurada, S; Sakurada, T; Sato, T; Sawai, T; Watanabe, C; Watanabe, H; Yonezawa, A | 1 |
| Akil, H; Capriles, N; Cecchi, M; Watson, SJ | 1 |
| Hiramatsu, K; Khan, MS; Mori, M; Sugahara, K; Tachibana, T; Ueda, H | 1 |
| Barnes, MJ; Bray, GA; Primeaux, SD | 1 |
| Bagosi, Z; Jászberényi, M; Telegdy, G | 1 |
| Khan, MS; Masuda, N; Ohkubo, T; Tachibana, T; Ueda, H | 1 |
| Granero, L; Hipólito, L; Polache, A; Sánchez-Catalán, MJ; Zornoza, T | 2 |
| Matulonis, JE; Pan, YX; Pasternak, GW; Rossi, GC; Xu, J; Xu, M | 1 |
| Carliss, RD; Keefer, JF; Perschke, S; Rich, TC; Weissman, AD; Welch, S | 1 |
| Cline, MA; Hiramatsu, K; Sugahara, K; Tachibana, T; Ueda, H | 1 |
| Chen, YF; Chiang, HM; Tsai, HY; Tsai, YT | 1 |
| Cravezic, A; do-Rego, JC; Fichna, J; Janecka, A; Perlikowska, R; Toth, G; Wyrebska, A | 1 |
| Arbogast, LA; Tavakoli-Nezhad, M | 1 |
| Jin, WY; Liu, D; Liu, Z; Yu, LC | 1 |
| Berthoud, HR; Lenard, NR; Zheng, H | 1 |
| Komatsu, H; Mizoguchi, H; Ohkawara, Y; Ohno, I; Okuyama, K; Sakurada, S; Sora, I; Takayanagi, M; Tamura, G; Wada, K | 1 |
| Berthoud, HR; Phifer, CB; Pistell, PJ; Shin, AC | 1 |
| Baiula, M; Bedini, A; De Marco, R; Gentilucci, L; Spampinato, S; Tolomelli, A | 1 |
| Cui, Y; Jing, J; Liu, XG; Xin, WJ; Zhang, XQ | 1 |
| Chen, Q; Ge, WW; Lu, SS; Tian, XZ; Yang, AM; Yang, QZ | 1 |
| Buechler, NL; Childers, SR; Ewan, EE; Kim, SA; Martin, TJ; Xiao, R | 1 |
| Kinloch, RA; Nickolls, SA; Waterfield, A; Williams, RE | 1 |
| Granero, L; Hipólito, L; Martí-Prats, L; Polache, A; Sánchez-Catalán, MJ | 1 |
| Baraboi, ED; Guesdon, B; Hétu, M; Lopez, CA; Richard, D; Roffarello, BM | 1 |
| Chen, Q; Ge, WW; Lu, SS; Mi, ZY; Su, SF; Yang, AM; Yang, SB | 1 |
| Bakhle, YS; Camêlo, VM; Dos Reis, WG; Faraco, A; Francischi, JN; Paiva-Lima, P; Rezende, RM | 1 |
| Friedman, TC; Hamid, A; Kieffer, B; Lutfy, K; Marquez, P; Nguyen, AT | 1 |
| Chen, Q; Lv, SY; Qin, YJ; Wang, NB; Yang, YJ | 1 |
| Bobeck, EN; Haseman, RA; Hong, D; Ingram, SL; Morgan, MM | 1 |
| Altarifi, AA; Miller, LL; Negus, SS | 1 |
| Fichna, J; Gach, K; Janecka, A; Nieoczym, D; Perlikowska, R; Socała, K; Wlaź, P | 1 |
| Amaya, MI; de Gortari, P; Estrada-Camarena, E; Mejía-Mauríes, S; Mengod, G; Morales-Mulia, M; Sollozo-Dupont, I | 1 |
| Bagetta, G; Katsuyama, S; Komatsu, T; Kuwahata, H; Mizoguchi, H; Nagaoka, K; Nakamura, H; Sakurada, S; Sakurada, T | 1 |
| Chung, NN; Gibula-Bruzda, E; Izdebski, J; Kotlinska, JH; Schiller, PW; Witkowska, E | 1 |
| Buck, DJ; Das, S; Davis, RL; Stevens, CW | 1 |
| Gonzales, RA; Howard, EC; Job, MO; Mangieri, RA; Schier, CJ; Valenta, JP | 1 |
| Hisa, H; Mutoh, J; Ohsawa, M | 1 |
| Lee, H | 1 |
| Fukushima, Y; Hall, FS; Kitanaka, J; Kitanaka, N; Kubo, H; Morita, Y; Nishiyama, N; Sawai, T; Takahashi, H; Takemura, M; Tanaka, K; Tatsuta, T; Uhl, GR; Watabe, K | 1 |
| Brunetti, L; Chiavaroli, A; Di Nisio, C; Ferrante, C; Leone, S; Manippa, F; Mollica, A; Orlando, G; Recinella, L; Ricciuti, A; Shohreh, R; Vacca, M | 1 |
| Gibula-Bruzda, E; Izdebski, J; Kotlinska, JH; Witkowska, E | 1 |
| Heeman, JH; Quock, RM; Shirachi, DY; Zhang, Y | 1 |
| Kon-No, T; Mizoguchi, H; Sakurada, S; Sakurada, T; Sato, T; Watanabe, C; Watanabe, H; Yonezawa, A | 1 |
| Filer, CN; Seguin, RJ | 1 |
| Hamzah, AS; Kek, TL; Mansor, NS; Mohammat, MF; Salleh, MZ; Sani, MH; Shaameri, Z; Zakaria, ZA | 1 |
| Katsuura, Y; Taha, SA | 1 |
| Do Rego, JC; Fichna, J; Grzywacz, D; Kamysz, W; Polepally, PR; Sałaga, M; Sibaev, A; Sobczak, M; Storr, M; Zjawiony, JK | 1 |
| Chang, XM; Fang, Q; Han, ZL; Li, N; Li, XH; Pan, JX; Tang, HH; Wang, P; Wang, R; Wang, ZL; Zheng, T | 1 |
| Chen, L; Li, YQ; Mei, XP; Wang, K; Wang, W; Yang, T; Zhang, FX; Zhu, C | 1 |
| Chen, C; DiMattio, KM; Liu-Chen, LY; Shi, L | 1 |
| Gibula-Bruzda, E; Izdebski, J; Kotlinska, JH; Marszalek-Grabska, M; Witkowska, E | 1 |
| Chen, T; Dong, YL; Du, JQ; Feng, B; Hui, R; Huo, FQ; Li, J; Li, YQ; Yin, JB; Zhang, T | 1 |
| King, T; Navratilova, E; Okun, A; Porreca, F; Remeniuk, B; Sukhtankar, D; Xie, JY | 1 |
| Das, S; Davis, RL; Stevens, CW; Thomas Curtis, J | 1 |
| Lei, J; Xiao, Y; Xu, H; Ye, G; You, HJ | 1 |
| Akatsu, R; Horie, S; Kato, S; Matsumoto, K; Mori, T; Saito, S; Shibasaki, M; Suzuki, T; Tashima, K; Umemoto, H | 1 |
| Dong, YL; Li, H; Li, JL; Li, YQ; Lu, YC; Qi, J; Zhang, T; Zhao, TB | 1 |
| Kaserer, T; Lantero, A; Schmidhammer, H; Schuster, D; Spetea, M | 1 |
| Haji, A; Kimura, S; Ohi, Y | 1 |
| Hang, A; Liu, JG; Long, Y; Shu, XH; Wang, Q; Wang, YJ; Zan, GY | 1 |
| Davis, RL; Stevens, CW; Thomas Curtis, J | 1 |
| Cami-Kobeci, G; Fichna, J; Husbands, S; Jarmuż, A; Wasilewski, A; Zielińska, M | 1 |
| Aira, Z; Azkue, JJ; Buesa, I; Medrano, MC; Mendiguren, A; Pablos, P; Pineda, J; Santamarta, MT | 1 |
| Chan, YH; Wang, YT | 1 |
| Katsuyama, S; Komatsu, T; Kubota, A; Morinaga, O; Ogawa, K; Okamura, T; Sakurada, C; Sakurada, T; Tabata, K; Takano, F; Tsuzuki, M | 1 |
| Chang, CY; Chen, CJ; Chen, WY; Hung, CJ; Kuan, YH; Liao, SL; Lin, SY; Shih, KC; Wang, WY; Wang, YY; Wu, CC | 1 |
| Annibale, P; Bock, A; Grushevskyi, EO; Heilemann, M; Isbilir, A; Karathanasis, C; Lohse, MJ; Möller, J; Osberg, B; Schütte, C; Sungkaworn, T; Sunkara, V | 1 |
| Cao, D; Gillespie, JC; Liu-Chen, LY; Mendez, RE; Selley, DE; Wang, H; Zhang, Y | 1 |
| Chang, N; Chang, S; Duan, C; Jia, S; Shang, L | 1 |
1 trial(s) available for naltrexone and beta-funaltrexamine
| Article | Year |
|---|---|
Influence of opioids in hypothalamic nuclei on cold thermogenesis of lean and obese LA/N-cp rats.
Topics: Animals; Cold Temperature; Enkephalin, Leucine; Male; Naloxone; Naltrexone; Narcotic Antagonists; Obesity; Opioid Peptides; Oxygen Consumption; Paraventricular Hypothalamic Nucleus; Rats; Rats, Sprague-Dawley; Stress, Physiological; Thermogenesis | 1994 |
516 other study(ies) available for naltrexone and beta-funaltrexamine
| Article | Year |
|---|---|
A novel opioid receptor site directed alkylating agent with irreversible narcotic antagonistic and reversible agonistic activities.
Topics: Alkylating Agents; Animals; Guinea Pigs; In Vitro Techniques; Morphinans; Muscle Contraction; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Narcotics; Oxymorphone; Receptors, Opioid | 1980 |
Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors.
Topics: Analgesics; Animals; Binding Sites; Cell Line; CHO Cells; Cloning, Molecular; Cricetinae; Ligands; PC12 Cells; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Software | 1994 |
Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications.
Topics: Animals; Aorta, Thoracic; Cocaine; Cyclic AMP; Electric Stimulation; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Mice; Muscle, Smooth; Opioid-Related Disorders; Rats; Receptors, Dopamine; Receptors, Opioid; Receptors, Serotonin; Substance-Related Disorders | 1998 |
Design, synthesis, and biological evaluation of 6alpha- and 6beta-N-heterocyclic substituted naltrexamine derivatives as mu opioid receptor selective antagonists.
Topics: Amino Acid Sequence; Analgesics; Analgesics, Opioid; Animals; Binding Sites; Binding, Competitive; CHO Cells; Cricetinae; Cricetulus; Drug Design; Ligands; Models, Molecular; Molecular Sequence Data; Morphinans; Morphine; Naltrexone; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sequence Alignment; Structure-Activity Relationship | 2009 |
14-O-Heterocyclic-substituted naltrexone derivatives as non-peptide mu opioid receptor selective antagonists: design, synthesis, and biological studies.
Topics: Binding, Competitive; Chemistry, Pharmaceutical; Drug Design; Humans; Kinetics; Ligands; Molecular Conformation; Molecular Structure; Naltrexone; Narcotic Antagonists; Nitrogen; Peptides; Protein Structure, Tertiary; Receptors, Opioid, mu | 2009 |
Antitrichomonal activity of δ opioid receptor antagonists, 7-benzylidenenaltrexone derivatives.
Topics: Animals; Antitrichomonal Agents; Benzylidene Compounds; CHO Cells; Cricetulus; Dose-Response Relationship, Drug; Molecular Structure; Naltrexone; Receptors, Opioid, delta; Structure-Activity Relationship; Trichomonas vaginalis | 2017 |
Comparison of the neurochemistry of the endogenous opioid systems in two brainstem pain-processing centers.
Topics: Animals; Brain Stem; Dipeptides; Dose-Response Relationship, Drug; Medulla Oblongata; Microinjections; Naloxone; Naltrexone; Neprilysin; Pain; Periaqueductal Gray; Rats | 1992 |
Effects of [D-Ala2, D-Leu5]enkephalin and [D-Pen2, L-Pen5]enkephalin on apomorphine-induced motor activity in the mouse.
Topics: Analgesics; Animals; Apomorphine; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Grooming; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Motor Activity; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Stereotyped Behavior | 1992 |
Kappa opioid mediation of fetal responses to milk.
Topics: Aging; Animals; Arousal; Chemoreceptor Cells; Dose-Response Relationship, Drug; Female; Fetal Movement; Gestational Age; Morphine; Motor Activity; Naloxone; Naltrexone; Pregnancy; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Sucking Behavior; Taste; Touch | 1992 |
Interaction between opioid antagonists and amphetamine: evidence for mediation by central delta opioid receptors.
Topics: Amphetamine; Analgesia; Animals; Brain; Indoles; Male; Morphinans; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta | 1992 |
Effects of diabetes on stress-induced analgesia in mice.
Topics: Animals; Diabetes Mellitus, Experimental; Male; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Physical Exertion; Receptors, Opioid, mu; Sensory Thresholds; Stress, Physiological | 1992 |
Pentobarbital attenuates antinociception induced by i.c.v. morphine but not beta-endorphin in the mouse.
Topics: Animals; beta-Endorphin; Drug Interactions; Enkephalin, Leucine; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Narcotic Antagonists; Nociceptors; Pentobarbital; Receptors, Opioid | 1992 |
Nalbuphine, a mixed kappa 1 and kappa 3 analgesic in mice.
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Injections, Spinal; Male; Mice; Nalbuphine; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, kappa | 1992 |
Mu- and kappa-opiate receptor control of prolactin secretion in rats: ontogeny and interaction with serotonin.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Aging; Animals; Cyproheptadine; Female; Kinetics; Male; Naltrexone; Prolactin; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Serotonin; Sufentanil | 1992 |
Pharmacological profiles of fentanyl analogs at mu, delta and kappa opiate receptors.
Topics: Analgesics, Opioid; Animals; Benzeneacetamides; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fentanyl; Guinea Pigs; Ileum; Male; Mice; Naltrexone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vas Deferens | 1992 |
Alkylation with beta-funaltrexamine suggests differences between mu-opioid receptor systems in guinea-pig brain and myenteric-plexus.
Topics: Alkylating Agents; Alkylation; Animals; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; In Vitro Techniques; Male; Myenteric Plexus; Naltrexone; Receptors, Opioid, mu | 1991 |
Identification of a novel receptor mediating substance P-induced behavior in the mouse.
Topics: Analysis of Variance; Animals; Behavior, Animal; Binding Sites; Indoles; Injections, Spinal; Male; Mice; Morphinans; Naloxone; Naltrexone; Peptide Fragments; Substance P | 1992 |
Effects of beta-funaltrexamine on butorphanol dependence.
Topics: Animals; Behavior, Animal; Body Temperature; Body Weight; Butorphanol; Dose-Response Relationship, Drug; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Reinforcement Schedule; Substance Withdrawal Syndrome; Substance-Related Disorders | 1992 |
Autoradiographic study of irreversible binding of [3H]beta-funaltrexamine to opioid receptors in the rat forebrain: comparison with mu and delta receptor distribution.
Topics: Animals; Autoradiography; Diencephalon; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Telencephalon; Tritium | 1991 |
Pentazocine-induced biphasic analgesia in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics; Animals; Drug Administration Schedule; Drug Interactions; Drug Tolerance; Indoles; Injections, Intraventricular; Male; Mice; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Pentazocine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Time Factors | 1991 |
Differential antagonism of U69,593- and bremazocine-induced antinociception by (-)-UPHIT: evidence of kappa opioid receptor multiplicity in mice.
Topics: Analgesics; Animals; Benzeneacetamides; Benzomorphans; Cyclohexanes; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1991 |
Endogenous opioids tonically inhibit the depressor neurones in the caudal ventrolateral medulla of rabbits: mediation through delta- and kappa-receptors.
Topics: Amino Acid Sequence; Animals; Endorphins; Enkephalin, Leucine; Hemodynamics; Male; Medulla Oblongata; Molecular Sequence Data; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Rabbits; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa | 1991 |
Ontogeny of mu- and kappa-opiate receptor control of the hypothalamo-pituitary-adrenal axis in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenal Glands; Adrenocorticotropic Hormone; Animals; Corticosterone; Dexamethasone; Female; Hypothalamus; Kinetics; Morphine; Naltrexone; Pituitary Gland; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1991 |
Characteristics of dose-dependent antagonism by beta-funaltrexamine of the antinociceptive effects of intrathecal mu agonists.
Topics: Analgesics; Animals; Binding, Competitive; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fentanyl; Injections, Spinal; Male; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Spinal Cord; Sufentanil | 1991 |
Interaction of beta-funaltrexamine with [3H]cycloFOXY binding in rat brain: further evidence that beta-FNA alkylates the opioid receptor complex.
Topics: Alkylating Agents; Alkylation; Analgesics; Animals; Brain; Enkephalin, Leucine-2-Alanine; Injections, Intraventricular; Kinetics; Ligands; Male; Mice; Mice, Inbred ICR; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Surface Properties | 1991 |
Evaluation of receptor mechanism mediating fentanyl analgesia and toxicity.
Topics: Analgesics; Animals; Brain; Drug Tolerance; Fentanyl; Lethal Dose 50; Male; Mice; Morphine; Naloxone; Naltrexone; Receptors, Opioid | 1991 |
Delta receptor involvement in morphine suppression of noxiously evoked activity of spinal WDR neurons in cats.
Topics: Analgesia; Animals; Cats; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Evoked Potentials; Female; Hot Temperature; Injections, Spinal; Male; Morphine; Naltrexone; Narcotic Antagonists; Neurons; Pain; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord | 1991 |
Cross-tolerance studies in the spinal cord of beta-FNA-treated mice provides further evidence for delta opioid receptor subtypes.
Topics: Animals; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Spinal; Male; Mice; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord | 1991 |
Ingestive behavior following central [D-Ala2, Leu5, Cys6]-enkephalin (DALCE), a short-acting agonist and long-acting antagonist at the delta opioid receptor.
Topics: Animals; Deoxyglucose; Diet; Dietary Fats; Dose-Response Relationship, Drug; Enkephalin, Leucine-2-Alanine; Feeding Behavior; Food Deprivation; Glucose; Injections, Intraventricular; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid, delta | 1991 |
DAGO ([D-Ala2,N-Me-Phe4,Gly-ol]enkephalin) specifically reverses apomorphine-induced increase in rearing and grooming behaviors in the mouse.
Topics: Animals; Apomorphine; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Grooming; Injections, Intraventricular; Mice; Mice, Inbred Strains; Motor Activity; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, mu | 1991 |
Beta-funaltrexamine (beta-FNA) decreases deprivation and opioid-induced feeding.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Feeding Behavior; Food Deprivation; Injections, Intraventricular; Male; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa | 1991 |
An enkephalinergic mechanism involved in amygdaloid suppression of affective defence behavior elicited from the midbrain periaqueductal gray in the cat.
Topics: Affect; Aggression; Amygdala; Animals; Cats; Electric Stimulation; Enkephalin, Leucine; Enkephalins; Female; Fluorescent Dyes; Homocysteine; Immunohistochemistry; Male; Naloxone; Naltrexone; Narcotic Antagonists; Periaqueductal Gray; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Stereotyped Behavior; Stilbamidines | 1991 |
Effects of intracerebroventricular beta-funaltrexamine on mu and delta opioid receptors in the rat: dichotomy between binding and antinociception.
Topics: Animals; Brain; Cerebral Cortex; Corpus Striatum; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intravenous; Kinetics; Male; Morphine; Naltrexone; Narcotic Antagonists; Nociceptors; Periaqueductal Gray; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Thalamus; Time Factors; Tritium | 1991 |
Inhibition of suckling-induced prolactin release by mu- and kappa-opioid antagonists.
Topics: Animals; Depression, Chemical; Dose-Response Relationship, Drug; Female; Injections, Intraventricular; Lactation; Luteinizing Hormone; Naloxone; Naltrexone; Narcotic Antagonists; Prolactin; Rats; Rats, Inbred Strains; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1991 |
mu-receptor mediates elevated glucose and corticosterone after third ventricle injection of opioid peptides.
Topics: Animals; beta-Endorphin; Blood Glucose; Cerebral Ventricles; Corticosterone; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Fatty Acids, Nonesterified; Injections, Intraventricular; Male; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu | 1991 |
Hippocampal mu-receptors mediate opioid reinforcement in the CA3 region.
Topics: Animals; Dynorphins; Enkephalin, Leucine; Hippocampus; Kinetics; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pyramidal Tracts; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Reference Values; Reinforcement, Psychology; Self Administration | 1991 |
Opioid mu and delta receptor antagonists reduce wet dog shaking elicited by perforant path stimulation.
Topics: Animals; Dynorphins; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Methionine; gamma-Aminobutyric Acid; Hippocampus; Male; Naltrexone; Peptide Fragments; Rats; Rats, Inbred F344; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Stereotyped Behavior | 1991 |
Effect of opioid receptor antagonists on vasodilator nerve actions in the perfused rat mesentery.
Topics: Animals; Calcitonin Gene-Related Peptide; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Guanethidine; In Vitro Techniques; Male; Mesenteric Arteries; Methoxamine; Muscle, Smooth, Vascular; Naloxone; Naltrexone; Narcotic Antagonists; Neurons, Afferent; Perfusion; Rats; Rats, Inbred Strains; Somatostatin; Vasodilation | 1991 |
[D-Ala2,NMePhe4,Gly-ol5]enkephalin, but not [D-Pen2,L-Pen5]enkephalin, specifically inhibits behaviors induced by the dopamine D2 agonist RU 24213.
Topics: Analysis of Variance; Animals; Behavior, Animal; Dopamine Agents; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Motor Activity; Naltrexone; Phenethylamines | 1991 |
Activation of mu opioid receptors inhibits transient high- and low-threshold Ca2+ currents, but spares a sustained current.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Sequence; Animals; Calcium Channels; Cells, Cultured; Electric Conductivity; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Molecular Sequence Data; Mollusk Venoms; Naltrexone; Narcotic Antagonists; omega-Conotoxin GVIA; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1991 |
Chronic selective blockade of mu opioid receptors produces analgesia and augmentation of the effects of a kappa agonist.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics; Animals; Injections, Intraventricular; Injections, Subcutaneous; Male; Mice; Mice, Inbred Strains; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Pyrrolidines; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stereotaxic Techniques | 1991 |
Effects of selective opiate antagonists on morphine-induced hyperalgesia in domestic fowl.
Topics: Analgesia; Animals; Chickens; Dose-Response Relationship, Drug; Hot Temperature; Indoles; Injections, Intraventricular; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Respiration | 1991 |
Differential antagonism of delta opioid agonists by naltrindole and its benzofuran analog (NTB) in mice: evidence for delta opioid receptor subtypes.
Topics: Analgesia; Animals; Indoles; Male; Mice; Morphinans; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta | 1991 |
Comparison of naloxonazine and beta-funaltrexamine antagonism of mu 1 and mu 2 opioid actions.
Topics: Animals; Drug Administration Schedule; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Subcutaneous; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, mu | 1991 |
Endothelin-1-induced nociception.
Topics: Animals; Endothelins; Male; Mice; Morphine; Naloxone; Naltrexone; Pain; Pain Measurement | 1991 |
Reduction by central beta-funaltrexamine of food intake in rats under freely-feeding, deprivation and glucoprivic conditions.
Topics: Animals; Corpus Striatum; Dietary Carbohydrates; Dose-Response Relationship, Drug; Feeding Behavior; Food Deprivation; Glucose; Hypothalamus; Injections, Intraventricular; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Time Factors | 1990 |
Pretreatment of rats with the irreversible mu-receptor antagonist, beta-FNA, fails to prevent naltrexone-induced upregulation of mu-opioid receptors.
Topics: Animals; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; In Vitro Techniques; Isothiocyanates; Kinetics; Naltrexone; Narcotic Antagonists; Oxymorphone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Thiocyanates; Up-Regulation | 1990 |
The effects of mu, delta- and kappa-opioid receptor antagonists on the pain threshold increase following muscle stimulation in the rat.
Topics: Analgesia; Animals; Electric Stimulation; Male; Muscles; Naltrexone; Narcotic Antagonists; Pain; Rats; Rats, Inbred SHR; Receptors, Opioid; Receptors, Opioid, mu | 1990 |
Electric muscle stimulation in the spontaneously hypertensive rat induces a post-stimulatory reduction in activity: role of different opioid receptors.
Topics: Animals; Benzomorphans; Electric Stimulation; Hypertension; Male; Motor Activity; Muscles; Naloxone; Naltrexone; Rats; Rats, Inbred SHR; Receptors, Opioid | 1990 |
beta-Funaltrexamine antagonizes the analgesic effects of mu and kappa agonists in the formalin test.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Dose-Response Relationship, Drug; Ethylketocyclazocine; Formaldehyde; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Urination | 1990 |
A study of central opioid receptor involvement in nitrous oxide analgesia in mice.
Topics: Analgesia; Animals; Binding, Competitive; Injections, Intraventricular; Injections, Spinal; Male; Mice; Naltrexone; Nitrous Oxide; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1990 |
Tonic opioid inhibition of the pressor region of the rostral ventrolateral medulla of rabbits is mediated by delta receptors.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Glutamates; Glutamic Acid; Hemodynamics; Male; Medulla Oblongata; Microinjections; Naltrexone; Narcotic Antagonists; Pressoreceptors; Rabbits; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1990 |
Evidence that the agonist action of dynorphin A(1-8) in the guinea-pig myenteric-plexus may be mediated partly through conversion to [Leu5]enkephalin.
Topics: Animals; Dynorphins; Enkephalin, Leucine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Myenteric Plexus; Naltrexone; Narcotic Antagonists; Peptide Fragments; Receptors, Opioid | 1990 |
Studies on kinetics of [3H]beta-funaltrexamine binding to mu opioid receptor.
Topics: Animals; Cattle; Corpus Striatum; In Vitro Techniques; Kinetics; Models, Chemical; Naltrexone; Radioligand Assay; Receptors, Opioid; Receptors, Opioid, mu; Sodium Chloride; Temperature | 1990 |
Supraspinal analgesic action of pentazocine in mice.
Topics: Analgesics; Animals; Drug Tolerance; Indoles; Injections, Intraventricular; Male; Mice; Morphinans; Naltrexone; Pain Measurement; Pentazocine; Receptors, Opioid; Time Factors | 1990 |
Kinetic studies on binding of [3H] beta-funaltrexamine ([3H] beta-FNA) to mu opioid receptors.
Topics: Animals; Binding Sites; Cattle; Corpus Striatum; In Vitro Techniques; Kinetics; Naltrexone; Receptors, Opioid; Receptors, Opioid, mu | 1990 |
[3H] beta-funaltrexamine ([3H] beta-FNA) binds irreversibly to mu opioid receptors in the rat brain: autoradiographic study.
Topics: Animals; Autoradiography; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Male; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1990 |
Selective opioid receptor antagonist effects upon intake of a high-fat diet in rats.
Topics: Animals; Dietary Fats; Dose-Response Relationship, Drug; Feeding Behavior; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid | 1990 |
Mu antagonist and kappa agonist properties of beta-funaltrexamine (beta-FNA) in vivo: long-lasting spinal analgesia in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics; Animals; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1990 |
Mediation of nitrous oxide analgesia in mice by spinal and supraspinal kappa-opioid receptors.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Naltrexone; Nitrous Oxide; Pain Measurement; Receptors, Opioid; Receptors, Opioid, kappa; Spinal Cord | 1990 |
Delta but not mu-opioid receptors in the spinal cord are involved in antinociception induced by beta-endorphin given intracerebroventricularly in mice.
Topics: Analgesia; Animals; beta-Endorphin; Enkephalin, Leucine; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord | 1990 |
Nicotine protects against mu-opioid receptor antagonism by beta-funaltrexamine: evidence for nicotine-induced release of endogenous opioids in brain.
Topics: Analgesia; Animals; Brain; Endorphins; Injections, Intraventricular; Male; Morphine; Naltrexone; Nicotine; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu | 1990 |
Stereoselectivity and subtype of the opiate receptor involved in stress-induced hypertension.
Topics: Animals; Blood Pressure; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Hypertension; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Social Isolation; Stereoisomerism; Stress, Psychological | 1990 |
Antinociceptive effects of [D-Ala2]deltorphin II, a highly selective delta agonist in vivo.
Topics: Analgesics; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Injections, Intraventricular; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Narcotic Antagonists; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta | 1990 |
Morphine promotes the growth of HIV-1 in human peripheral blood mononuclear cell cocultures.
Topics: Cells, Cultured; Gene Products, gag; HIV Core Protein p24; HIV-1; Humans; Leukocytes, Mononuclear; Lymphocyte Activation; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Viral Core Proteins | 1990 |
Assessment of relative intrinsic activity of mu-opioid analgesics in vivo by using beta-funaltrexamine.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Fentanyl; Levorphanol; Male; Methadone; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Time Factors | 1990 |
Role of opioid receptors in the long-lasting blood pressure depression after electric muscle stimulation in the hind leg of the rat.
Topics: Animals; Benzomorphans; Blood Pressure; Electric Stimulation; Enkephalin, Leucine; Heart Rate; Hindlimb; Male; Naloxone; Naltrexone; Physical Conditioning, Animal; Rats; Rats, Inbred SHR; Receptors, Opioid; Regional Blood Flow | 1990 |
[D-Pen2, D-Pen5]enkephalin, the standard delta opioid agonist, induces morphine-like behaviors in mice.
Topics: Analgesics; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Motor Activity; Muscle Tonus; Naloxone; Naltrexone; Narcotic Antagonists; Stereotyped Behavior | 1990 |
Action of naloxone on myenteric neurons removed from morphine-treated guinea pigs.
Topics: Acetylcholine; Action Potentials; Animals; Endorphins; Guinea Pigs; Ileum; In Vitro Techniques; Magnesium; Morphine; Muscle Contraction; Myenteric Plexus; Naloxone; Naltrexone; Substance P | 1988 |
Evidence of single dose opioid dependence in 12- to 14-day-old chicken embryos.
Topics: 1-Methyl-3-isobutylxanthine; 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Chick Embryo; Methadone; Morphine Dependence; Motor Activity; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Pyrrolidines; Receptors, Opioid; Substance Withdrawal Syndrome | 1989 |
Chronic administration of morphine and naltrexone up-regulate mu-opioid binding sites labeled by [3H][D-Ala2,MePhe4,Gly-ol5]enkephalin: further evidence for two mu-binding sites.
Topics: Animals; Benzomorphans; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; In Vitro Techniques; Male; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1989 |
Beta-funaltrexamine disrupts the day-night rhythm of nociception in mice.
Topics: Animals; Circadian Rhythm; Male; Mice; Naltrexone; Narcotic Antagonists; Nociceptors; Pain; Receptors, Opioid; Receptors, Opioid, mu | 1989 |
Delta-opioid mediated inhibitions of acute and prolonged noxious-evoked responses in rat dorsal horn neurones.
Topics: Animals; Electric Stimulation; Enkephalin, Leucine; Evoked Potentials; In Vitro Techniques; Male; Naltrexone; Narcotic Antagonists; Neurons; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta | 1989 |
Modulation of mu-mediated antinociception by delta agonists: characterization with antagonists.
Topics: Analgesics; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1989 |
Mu antagonist and kappa agonist properties of b-funaltrexamine (b-FNA): long lasting spinal antinociception.
Topics: Animals; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Nociceptors; Reaction Time; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1989 |
Evaluation of delta receptor mediation of supraspinal opioid analgesia by in vivo protection against the beta-funaltrexamine antagonist effect.
Topics: Analgesics, Opioid; Animals; Brain Chemistry; Dihydromorphine; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; In Vitro Techniques; Injections, Intraventricular; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Pain Measurement; Receptors, Opioid; Receptors, Opioid, delta | 1989 |
Lack of mixed agonist-antagonist properties of [Gln8-Gly31]-beta h-EP-Gly-Gly-NH2 and [Arg9,19,24,28,29]-beta h-EP in the rat vas deferens neuroeffector junction: studies with naloxone, beta-funaltrexamine and ICI 174,864.
Topics: Animals; beta-Endorphin; Endorphins; Enkephalin, Leucine; In Vitro Techniques; Male; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists; Neuroeffector Junction; Rats; Rats, Inbred Strains; Vas Deferens | 1989 |
Intracerebroventricular physostigmine-induced analgesia: enhancement by naloxone, beta-funaltrexamine and nor-binaltorphimine and antagonism by dynorphin A (1-17).
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Dynorphins; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Narcotic Antagonists; Physostigmine; Time Factors | 1989 |
Effects of beta-funaltrexamine on radiolabeled opioid binding.
Topics: Animals; Binding, Competitive; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; In Vitro Techniques; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu | 1987 |
Evidence for the interaction of morphine with kappa and delta opioid receptors to induce analgesia in beta-funaltrexamine-treated mice.
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa | 1987 |
Covalent labeling of mu opioid binding site by [3H]beta-funaltrexamine.
Topics: Animals; Cattle; Chemical Phenomena; Chemistry; Chromatography, Affinity; Corpus Striatum; Electrophoresis, Polyacrylamide Gel; Kinetics; Ligands; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Temperature; Time Factors | 1987 |
Buprenorphine has potent kappa opioid receptor antagonist activity.
Topics: Animals; Benzomorphans; Buprenorphine; Diuresis; Drug Combinations; Male; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid | 1987 |
Opioid delta-receptor involvement in supraspinal and spinal antinociception in mice.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Drug Combinations; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Hot Temperature; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Nociceptors; Pain; Receptors, Opioid; Receptors, Opioid, delta; Spinal Cord | 1987 |
Opiate receptors and the endorphin-mediated cardiovascular effects of clonidine in rats: evidence for hypertension-induced mu-subtype to delta-subtype changes.
Topics: Animals; Blood Pressure; Clonidine; Endorphins; Enkephalin, Leucine; Heart Rate; Hypertension; Male; Naloxone; Naltrexone; Rats; Rats, Inbred SHR; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1987 |
Effects of stress and beta-funal trexamine pretreatment on morphine analgesia and opioid binding in rats.
Topics: Analgesia; Animals; Brain; Male; Morphine; Naltrexone; Narcotics; Rats; Rats, Inbred Strains; Receptors, Opioid; Stress, Physiological | 1987 |
Opioid analgesia in the mouse: evidence for multiple receptors using beta-FNA.
Topics: Analgesia; Animals; Enkephalins; Male; Mice; Mice, Inbred Strains; Morphine; Naltrexone; Narcotic Antagonists; Pain; Receptors, Opioid | 1986 |
New approaches to the evaluation of opioid agonists and antagonists upon the isolated, electrically stimulated mouse vas deferens preparation.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Benzomorphans; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Oligopeptides; Pyrrolidines; Receptors, Opioid; Vas Deferens | 1987 |
Role of the spinal cord in the development of opiate tolerance and dependence.
Topics: Animals; Drug Tolerance; Naltrexone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Rats; Receptors, Opioid; Spinal Cord | 1987 |
Opioid gene expression in rat striatum is modulated via opioid receptors: evidence from localized receptor inactivation.
Topics: Animals; Corpus Striatum; Enkephalins; Gene Expression Regulation; Male; Naltrexone; Protein Precursors; Rats; Rats, Inbred Strains; Receptors, Opioid; RNA, Messenger | 1988 |
Effects of beta-funaltrexamine on ingestive behaviors in the rat.
Topics: Animals; Drinking Behavior; Feeding Behavior; Injections, Intraventricular; Male; Motor Activity; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu | 1988 |
beta-FNA binds irreversibly to the opiate receptor complex: in vivo and in vitro evidence.
Topics: Animals; Binding Sites; Binding, Competitive; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Injections, Intraventricular; Male; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1988 |
Suppression by nor-binaltorphimine of kappa opioid-mediated diuresis in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Diuresis; Dose-Response Relationship, Drug; Male; Morphine; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa | 1988 |
Kappa antagonist properties of buprenorphine in the shock titration procedure.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Buprenorphine; Electroshock; Fentanyl; Male; Naltrexone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Saimiri | 1988 |
Buprenorphine is a potent kappa-opioid receptor antagonist in pigeons and mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Buprenorphine; Columbidae; Male; Mice; Muscle Contraction; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Reinforcement Schedule | 1988 |
Lack of evidence for epsilon-opioid receptors in the rat vas deferens.
Topics: Animals; Calcium; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; In Vitro Techniques; Male; Muscle Contraction; Naloxone; Naltrexone; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Vas Deferens | 1988 |
Opposite effects of mu and kappa opiate agonists on dopamine release in the nucleus accumbens and in the dorsal caudate of freely moving rats.
Topics: Animals; Benzomorphans; Caudate Nucleus; Dopamine; Male; Methadone; Morphine; Motor Activity; Naloxone; Naltrexone; Nucleus Accumbens; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reward; Septal Nuclei | 1988 |
Selective inactivation of opioid receptors in rat hippocampus demonstrates that dynorphin-A and -B may act on mu-receptors in the CA1 region.
Topics: Animals; Dynorphins; Endorphins; Hippocampus; In Vitro Techniques; Naltrexone; Rats; Receptors, Opioid; Receptors, Opioid, mu | 1985 |
Effect of beta-funaltrexamine on opioid side-effects produced by morphine and U-50, 488H.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Body Temperature; Depression, Chemical; Dose-Response Relationship, Drug; Gastrointestinal Motility; Hypnotics and Sedatives; Male; Morphine; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rats; Rats, Inbred Strains; Respiration | 1985 |
High doses of L-naloxone but neither D-naloxone nor beta-funaltrexamine prevent hyperthermia-induced seizures in rat pups.
Topics: Animals; Body Temperature; Hyperthermia, Induced; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Seizures; Stereoisomerism | 1988 |
Intrathecal beta-funaltrexamine antagonizes intracerebroventricular beta-endorphin- but not morphine-induced analgesia in mice.
Topics: Analgesia; Animals; beta-Endorphin; Cerebral Ventricles; Dose-Response Relationship, Drug; Injections, Intraventricular; Injections, Spinal; Male; Mice; Models, Neurological; Morphine; Naltrexone; Narcotic Antagonists; Spinal Cord | 1988 |
Comparisons of descending pain inhibitory pathways activated by beta-endorphin and morphine as characterized by supraspinal and spinal antinociceptive interactions in mice.
Topics: Analgesia; Animals; beta-Endorphin; Drug Tolerance; Efferent Pathways; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Pain; Spinal Cord | 1988 |
Possible delta receptor mediation of the effect of beta-endorphin on luteinizing hormone (LH) release, but not on prolactin (PRL) release, in the ovariectomized rat.
Topics: Animals; beta-Endorphin; Castration; Endorphins; Enkephalin, Leucine; Female; Kinetics; Luteinizing Hormone; Naloxone; Naltrexone; Narcotic Antagonists; Prolactin; Rats; Rats, Inbred Strains; Receptors, Opioid | 1985 |
Opioid receptor binding characteristics of the non-equilibrium mu antagonist, beta-funaltrexamine (beta-FNA).
Topics: Animals; Brain; Enkephalin, Methionine; In Vitro Techniques; Ligands; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tritium | 1985 |
Prolonged in vivo antagonism of central mu- and delta-opioid receptor activity by beta-funal trexamine.
Topics: Animals; Female; Injections, Intraventricular; Injections, Spinal; Muscle Contraction; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Urinary Bladder | 1985 |
Effects of opiates on urine output in the water-loaded rat and reversal by beta-funaltrexamine.
Topics: Animals; Diuresis; Male; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1985 |
Plasma corticosterone changes in response to central or peripheral administration of kappa and sigma opiate agonists.
Topics: Animals; Brain; Corticosterone; Cyclazocine; Ethylketocyclazocine; Humans; Hypothalamo-Hypophyseal System; Male; Morphine; Naloxone; Naltrexone; Opioid-Related Disorders; Phenazocine; Pituitary-Adrenal System; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, sigma | 1985 |
The anticonvulsant effects of DADLE are primarily mediated by activation of delta opioid receptors: interactions between delta and mu receptor antagonists.
Topics: Animals; Anticonvulsants; Cerebral Ventricles; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Seizures | 1985 |
Pre-incubation of guinea-pig myenteric plexus with beta-funaltrexamine: discrepancy between binding assays and bioassays.
Topics: Animals; Binding, Competitive; Brain; Cricetinae; Guinea Pigs; In Vitro Techniques; Male; Mice; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Naloxone; Naltrexone; Narcotic Antagonists; Rabbits; Rats; Receptors, Opioid | 1985 |
Effect of mu and kappa opioid receptor agonists on rat plasma corticosterone levels.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Benzomorphans; Corticosterone; Dose-Response Relationship, Drug; Fentanyl; Male; Morphine; Naloxone; Naltrexone; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1985 |
Receptors for opioid peptides in the guinea-pig ileum.
Topics: Alkylation; Animals; Dose-Response Relationship, Drug; Electric Stimulation; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Ileum; Male; Mice; Naloxone; Naltrexone; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Vas Deferens | 1985 |
Determination of the receptor selectivity of opioid agonists in the guinea-pig ileum and mouse vas deferens by use of beta-funaltrexamine.
Topics: Animals; Electric Stimulation; Endorphins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Vas Deferens | 1985 |
Effect of beta-funaltrexamine on retention of passive-avoidance conditioning.
Topics: Animals; Avoidance Learning; Conditioning, Classical; Male; Memory; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Retention, Psychology; Stimulation, Chemical | 1985 |
[3H]beta-funaltrexamine binds covalently to brain opioid receptors.
Topics: Animals; Binding Sites; Cattle; Corpus Striatum; Guinea Pigs; Male; Naloxone; Naltrexone; Receptors, Opioid; Time Factors | 1985 |
Activity of mu- and delta-selective opioid agonists in the guinea pig ileum preparation: differentiation into peptide and nonpeptide classes with beta-funaltrexamine.
Topics: Animals; Endorphins; Guinea Pigs; Ileum; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Nalorphine; Naloxone; Naltrexone; Narcotics; Peptides; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship | 1986 |
Activity of N-methyl-alpha- and -beta-funaltrexamine at opioid receptors.
Topics: Animals; Cysteine; Guinea Pigs; Ileum; Kinetics; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, mu; Structure-Activity Relationship | 1986 |
Reversal by beta-funaltrexamine of the antinociceptive effect of opioid agonists in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Buprenorphine; Cyclazocine; Ethylketocyclazocine; Fentanyl; Male; Naltrexone; Pain; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1986 |
Behavioral effects of opioid peptides selective for mu or delta receptors. I. Morphine-like discriminative stimulus effects.
Topics: Animals; beta-Endorphin; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Discrimination Learning; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Morphine; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1986 |
Behavioral effects of opioid peptides selective for mu or delta receptors. II. Locomotor activity in nondependent and morphine-dependent rats.
Topics: Animals; beta-Endorphin; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Morphine Dependence; Motor Activity; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1986 |
beta-Funaltrexamine (beta-FNA) and the regulation of body and brain development in rats.
Topics: Animals; Body Weight; Brain; Cerebellum; Female; Male; Morphine; Naltrexone; Nociceptors; Rats; Rats, Inbred Strains; Receptors, Opioid | 1986 |
Synthesis and biological activity of analogues of beta-chlornaltrexamine and beta-funaltrexamine at opioid receptors.
Topics: Naltrexone; Narcotic Antagonists; Receptors, Opioid; Structure-Activity Relationship | 1986 |
Irreversible blockage of opioid receptor types by ester homologues of beta-funaltrexamine.
Topics: Animals; Dihydromorphine; In Vitro Techniques; Morphine; Naltrexone; Narcotic Antagonists; Rats; Receptors, Opioid; Receptors, Opioid, mu; Structure-Activity Relationship | 1986 |
Reversible and irreversible binding of beta-funaltrexamine to mu, delta and kappa opioid receptors in guinea pig brain membranes.
Topics: Animals; Brain; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Ethylmaleimide; Guinea Pigs; Kinetics; Male; Membranes; Naloxone; Naltrexone; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sodium Chloride | 1986 |
Evidence for coupling of the kappa opioid receptor to brain GTPase.
Topics: Alkylation; Animals; Brain; Cell Membrane; Cerebellum; Endorphins; GTP Phosphohydrolases; Guinea Pigs; Macaca mulatta; Naloxone; Naltrexone; Phosphoric Monoester Hydrolases; Rats; Receptors, Opioid; Receptors, Opioid, kappa | 1986 |
Bremazocine is an agonist at kappa-opioid receptors and an antagonist at mu-opioid receptors in the guinea-pig myenteric plexus.
Topics: Animals; Benzomorphans; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Morphinans; Myenteric Plexus; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1986 |
Evidence for mu opioid receptor mediation of enkephalin-induced electroencephalographic seizures.
Topics: Animals; Electroencephalography; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Naloxone; Naltrexone; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Seizures | 1987 |
Use of beta-funaltrexamine to determine mu opioid receptor involvement in the analgesic activity of various opioid ligands.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Biological Assay; Buprenorphine; Butorphanol; Cyclazocine; Dose-Response Relationship, Drug; Ethylketocyclazocine; Etorphine; Fentanyl; Methadone; Mice; Morphine; Muscle Contraction; Nalbuphine; Nalorphine; Naltrexone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, mu | 1987 |
Diprenorphine has agonist activity at opioid kappa-receptors in the myenteric plexus of the guinea-pig ileum.
Topics: Animals; Cricetinae; Diprenorphine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphinans; Muscle Contraction; Myenteric Plexus; Naltrexone; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vas Deferens | 1987 |
Beta-funaltrexamine antagonizes the discriminative stimulus effects of morphine but not naltrexone in pigeons.
Topics: Animals; Columbidae; Discrimination, Psychological; Dose-Response Relationship, Drug; Morphine; Naltrexone | 1987 |
Reversal by beta-funaltrexamine and 16-methyl cyprenorphine of the antinociceptive effects of opioid agonists in the mouse and guinea-pig.
Topics: Abdomen; Animals; Guinea Pigs; Male; Mice; Morphinans; Muscle Contraction; Naltrexone; Narcotic Antagonists; Narcotics; Nociceptors; Pain | 1988 |
Kappa opioids in rhesus monkeys. II. Analysis of the antagonistic actions of quadazocine and beta-funaltrexamine.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Azocines; Benzomorphans; Cyclazocine; Diuresis; Endorphins; Ethylketocyclazocine; Female; Hot Temperature; Macaca mulatta; Male; Morphine; Naltrexone; Narcotic Antagonists; Pyrrolidines; Reaction Time; Tail | 1987 |
Irreversible binding of [3H]beta-funaltrexamine to brain slices of morphine-tolerant and -dependent mice.
Topics: Animals; Brain Chemistry; Corpus Striatum; Drug Tolerance; In Vitro Techniques; Male; Mesencephalon; Mice; Morphine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Stereoisomerism | 1988 |
Evaluation of the receptor selectivities of opioid drugs by investigating the block of their effect on urine output by beta-funaltrexamine.
Topics: Animals; Diuresis; Kidney; Kinetics; Male; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1987 |
Evidence for opioid and non-opioid forms of stress-induced analgesia in the snail, Cepaea nemoralis.
Topics: Animals; Cold Temperature; Endorphins; Enkephalin, Leucine; Hot Temperature; Naloxone; Naltrexone; Pain; Reaction Time; Snails; Stress, Physiological | 1987 |
Intrathecal beta-funaltrexamine (beta-FNA) is a long acting agonist in the mouse abdominal stretch test.
Topics: Animals; Behavior, Animal; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Naltrexone; Reflex | 1987 |
Crystal structures of alpha- and beta-funaltrexamine: conformational requirement of the fumaramate moiety in the irreversible blockage of mu opioid receptors.
Topics: Crystallography; Isomerism; Models, Molecular; Naltrexone; Protein Conformation; X-Ray Diffraction | 1986 |
Effects of beta-funaltrexamine (beta-FNA) on morphine dependence in rats and monkeys.
Topics: Animals; Body Weight; Dose-Response Relationship, Drug; Macaca mulatta; Male; Morphine Dependence; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Species Specificity; Substance Withdrawal Syndrome; Time Factors | 1986 |
Effects of buprenorphine on shock titration in squirrel monkeys.
Topics: Animals; Buprenorphine; Conditioning, Operant; Diprenorphine; Dose-Response Relationship, Drug; Drug Interactions; Electroshock; Male; Morphinans; Morphine; Naloxone; Naltrexone; Saimiri | 1985 |
beta-Funaltrexamine (beta-FNA) and neural tumor response in mice.
Topics: Animals; Male; Mice; Mice, Inbred A; Morphine; Naltrexone; Narcotic Antagonists; Neoplasm Transplantation; Neuroblastoma; Reaction Time | 1985 |
Effects of beta-funaltrexamine in normal and morphine-dependent rhesus monkeys: observational studies.
Topics: Animals; Azocines; Behavior, Animal; Dose-Response Relationship, Drug; Injections, Intraventricular; Injections, Subcutaneous; Macaca mulatta; Morphine; Muscle Relaxation; Naloxone; Naltrexone; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors | 1985 |
Antagonistic and rate-suppressing effects of opioid antagonists in the pigeon.
Topics: Animals; Azocines; Benzomorphans; Buprenorphine; Columbidae; Conditioning, Operant; Diprenorphine; Dose-Response Relationship, Drug; Morphine; Naloxone; Naltrexone; Narcotic Antagonists | 1985 |
Effect of beta-FNA on opiate delta receptor binding.
Topics: Animals; Brain; Cell Membrane; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Naloxone; Naltrexone; Oligopeptides; Protein Conformation; Rats; Receptors, Opioid | 1984 |
Role of spinal mu opioid receptors in the development of morphine tolerance and dependence.
Topics: Analgesia; Animals; Body Weight; Drug Tolerance; Humans; Male; Morphine; Morphine Dependence; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Spinal Cord | 1984 |
Opiate-receptor interactions on single locus coeruleus neurones.
Topics: Action Potentials; Animals; Enkephalin, Methionine; In Vitro Techniques; Locus Coeruleus; Morphine Derivatives; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Neurons; Rats; Receptors, Opioid | 1984 |
Mu and delta opioid receptor interactions in a rat model of drug induced seizures.
Topics: Animals; Disease Models, Animal; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Seizures | 1984 |
Comparison of "selective" opiate receptor antagonists on the isolated mouse vas deferens.
Topics: Animals; Benzomorphans; Enkephalin, Leucine; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Vas Deferens | 1984 |
Acute and persistent effects of beta-funaltrexamine on the binding and agonist potencies of opioids in the myenteric plexus of the guinea-pig ileum.
Topics: Animals; Endorphins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Naltrexone; Rabbits; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vas Deferens | 1984 |
Effects of full and partial kappa agonists and mu agonists on urine output of normally hydrated rats.
Topics: Animals; Benzomorphans; Cyclazocine; Diuresis; Ethylketocyclazocine; Naltrexone; Narcotics; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1984 |
Pharmacological characterization in vivo of the novel opiate, beta-funaltrexamine.
Topics: Acetates; Acetic Acid; Analgesics, Opioid; Animals; Drug Interactions; Female; Male; Mice; Morphine; Nalorphine; Naloxone; Naltrexone; Narcotics; Pain; Reaction Time | 1982 |
Application of an irreversible opiate antagonist (beta-FNA, beta-funal-trexamine) to demonstrate dynorphin selectivity for K-opioid sites.
Topics: Animals; Binding, Competitive; Dose-Response Relationship, Drug; Dynorphins; Electric Stimulation; Endorphins; Guinea Pigs; Morphine Derivatives; Muscle, Smooth; Naloxone; Naltrexone; Receptors, Opioid; Time Factors | 1982 |
Relative involvement of mu, kappa and delta receptor mechanisms in opiate-mediated antinociception in mice.
Topics: Acetates; Acetic Acid; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Hot Temperature; Male; Mice; Naloxone; Naltrexone; Pain; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1983 |
Receptor preference of dynorphin A fragments in the mouse vas deferens determined by different techniques.
Topics: Animals; Drug Tolerance; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Fentanyl; Male; Mice; Naloxone; Naltrexone; Peptide Fragments; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vas Deferens | 1984 |
Pharmacological characterization of substance P-induced nociception in mice: modulation by opioid and noradrenergic agonists at the spinal level.
Topics: Animals; Dose-Response Relationship, Drug; Endorphins; Male; Mice; Naltrexone; Nociceptors; Norepinephrine; Receptors, Adrenergic, alpha; Spinal Cord; Substance P | 1983 |
The irreversible narcotic antagonistic and reversible agonistic properties of the fumaramate methyl ester derivative of naltrexone.
Topics: Affinity Labels; Animals; Ileum; Male; Mice; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Oxymorphone; Receptors, Opioid; Structure-Activity Relationship | 1981 |
Antagonism of morphine-induced behavioral suppression by opiate receptor alkylators.
Topics: Amphetamine; Animals; Brain; Conditioning, Operant; Exploratory Behavior; Male; Morphine; Muridae; Naloxone; Naltrexone; Nitrogen Mustard Compounds; Nociceptors; Receptors, Opioid | 1982 |
Pharmacological profiles of beta-funaltrexamine (beta-FNA) and beta-chlornaltrexamine (beta-CNA) on the mouse vas deferens preparation.
Topics: Animals; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Mice; Mice, Inbred Strains; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Vas Deferens | 1982 |
Improved assays for the assessment of kappa- and delta-properties of opioid ligands.
Topics: Animals; Cyclazocine; Ethylketocyclazocine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Vas Deferens | 1982 |
Relative involvement of receptor subtypes in opioid-induced inhibition of gastrointestinal transit in mice.
Topics: Animals; Charcoal; Cyclazocine; Drug Interactions; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Female; Gastrointestinal Motility; Male; Mice; Morphine; Nalorphine; Naltrexone; Receptors, Opioid | 1983 |
Determination of the relative involvement of mu-opioid receptors in opioid-induced depression of respiratory rate by use of beta-funaltrexamine.
Topics: Analgesics; Animals; Depression, Chemical; Drug Interactions; Female; Injections, Intraventricular; Male; Mice; Naloxone; Naltrexone; Narcotics; Reaction Time; Receptors, Opioid; Receptors, Opioid, mu; Respiration | 1983 |
Different receptor sites mediate opioid agonism and antagonism.
Topics: Animals; Binding Sites; Kinetics; Naltrexone; Narcotic Antagonists; Narcotics; Receptors, Opioid; Structure-Activity Relationship | 1983 |
Evidence for delta-receptor involvement in the post-ictal antinociceptive responses to electroconvulsive shock in rats.
Topics: Animals; Electroshock; Enkephalin, Leucine; Escape Reaction; Hot Temperature; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta | 1983 |
Multiple opioid receptors: evidence for mu-delta binding site interactions in endotoxic shock.
Topics: Animals; Blood Pressure; Enkephalin, Leucine; Heart Rate; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pulse; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Shock, Septic | 1983 |
Effect of beta-FNA on opiate receptor binding: preliminary evidence for two types of mu receptors.
Topics: Animals; Brain; In Vitro Techniques; Naloxone; Naltrexone; Oxymorphone; Rats; Receptors, Opioid; Receptors, Opioid, mu | 1983 |
ICI 154,129, a delta-opioid receptor antagonist raises seizure threshold in rats.
Topics: Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Seizures | 1984 |
Multiple opioid receptors in endotoxic shock: evidence for delta involvement and mu-delta interactions in vivo.
Topics: Allosteric Regulation; Animals; Blood Pressure; Enkephalin, Leucine; Macromolecular Substances; Male; Naltrexone; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Shock, Septic | 1984 |
Differential role of the opioid mu and delta receptors in the activation of prolactin (PRL) and growth hormone (GH) secretion by morphine in the male rat.
Topics: Animals; Drug Interactions; Enkephalin, Leucine; Growth Hormone; Injections, Intraventricular; Male; Morphine; Naloxone; Naltrexone; Prolactin; Rats; Rats, Inbred Strains; Receptors, Opioid | 1984 |
Effects of b-FNA in drug-naive and morphine-dependent rhesus monkeys.
Topics: Animals; Macaca mulatta; Morphine; Naltrexone; Substance-Related Disorders; Time Factors | 1984 |
Inhibition of morphine-induced analgesia and locomotor activity in strains of mice: a comparison of long-acting opiate antagonists.
Topics: Animals; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Morphine; Motor Activity; Naloxone; Naltrexone; Pain; Species Specificity | 1983 |
The in vitro pharmacological characterization of naloxone benzoylhydrazone.
Topics: Animals; Benzeneacetamides; Binding, Competitive; Computer Simulation; Cyclohexanes; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle, Smooth; Myenteric Plexus; Naloxone; Naltrexone; Narcotic Antagonists; Pyrrolidines; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1995 |
Opioid mu- and kappa-receptor mediate phospholipase C activation through Gi1 in Xenopus oocytes.
Topics: Animals; Benzeneacetamides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Enzyme Activation; Female; GTP-Binding Proteins; Naltrexone; Oocytes; Pyrrolidines; Receptors, Opioid, kappa; Receptors, Opioid, mu; Type C Phospholipases; Xenopus laevis | 1995 |
Opioids and nitric oxide contribute to hypoxia-induced pial arterial vasodilation in newborn pigs.
Topics: Amino Acid Oxidoreductases; Analysis of Variance; Animals; Animals, Newborn; Arginine; Arterioles; Cerebral Arteries; Cyclic GMP; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Female; Hypoxia; Male; Muscle, Smooth, Vascular; Naltrexone; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Nitroprusside; Receptors, Opioid, kappa; Receptors, Opioid, mu; Swine; Vasodilation | 1995 |
Inflammation enhances peripheral mu-opioid receptor-mediated analgesia, but not mu-opioid receptor transcription in dorsal root ganglia.
Topics: Amino Acid Sequence; Analgesia; Analgesics; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Foot; Ganglia, Spinal; Inflammation; Male; Molecular Sequence Data; Naltrexone; Narcotic Antagonists; Pain Measurement; Rats; Rats, Wistar; Receptors, Opioid, mu; Ribonucleases; RNA, Messenger | 1995 |
Electrophysiological demonstration and activation of mu-opioid receptors in the rabbit sinoatrial node.
Topics: Action Potentials; Animals; Enkephalin, Leucine; Fentanyl; Microelectrodes; Naltrexone; Narcotic Antagonists; Narcotics; Patch-Clamp Techniques; Rabbits; Receptors, Opioid, mu; Sinoatrial Node | 1995 |
Effects of mu opioid agonist and antagonist on neurological outcome following traumatic brain injury in the rat.
Topics: Animals; Brain Injuries; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Naltrexone; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Treatment Outcome | 1995 |
Selective actions of central mu and kappa opioid antagonists upon sucrose intake in sham-fed rats.
Topics: Animals; Cerebral Ventricles; Eating; Enkephalin, Leucine-2-Alanine; Infusions, Parenteral; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sucrose | 1995 |
Effects of a highly selective nonpeptide delta opioid receptor agonist, TAN-67, on morphine-induced antinociception in mice.
Topics: Analgesics; Animals; Drug Interactions; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Subcutaneous; Male; Mice; Mice, Inbred Strains; Morphine; Naltrexone; Nociceptors; Oligopeptides; Quinolines; Receptors, Opioid, delta | 1995 |
Reductions in body weight following chronic central opioid receptor subtype antagonists during development of dietary obesity in rats.
Topics: Animals; Body Weight; Dietary Fats; Eating; Male; Naloxone; Naltrexone; Narcotic Antagonists; Obesity; Rats; Rats, Sprague-Dawley; Time Factors | 1995 |
Characterization of irreversible binding of beta-funaltrexamine to the cloned rat mu opioid receptor.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Sequence; Animals; Cell Line; Cloning, Molecular; Diprenorphine; Electrophoresis, Polyacrylamide Gel; Enkephalin, Leucine; Glycosylation; Molecular Sequence Data; Naltrexone; Oligopeptides; Protein Binding; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Proteins; Sodium; Tritium | 1995 |
Modification of mu-opioid agonist-induced locomotor activity and development of morphine dependence by diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Mice; Mice, Inbred ICR; Morphine; Morphine Dependence; Motor Activity; Naloxone; Naltrexone; Receptors, Opioid, mu; Streptozocin | 1995 |
Alterations in deprivation, glucoprivic and sucrose intake following general, mu and kappa opioid antagonists in the hypothalamic paraventricular nucleus of rats.
Topics: Animals; Eating; Food Deprivation; Hypothalamus; Male; Naltrexone; Paraventricular Hypothalamic Nucleus; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sucrose | 1995 |
Analysis of central opioid receptor subtype antagonism of hypotonic and hypertonic saline intake in water-deprived rats.
Topics: Animals; Enkephalin, Leucine-2-Alanine; Hypotonic Solutions; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Saline Solution, Hypertonic; Water Deprivation | 1995 |
Activation of mu-opioid receptor modulates GABAA receptor-mediated currents in isolated spinal dorsal horn neurons.
Topics: Action Potentials; Amino Acid Sequence; Animals; Bicuculline; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Molecular Sequence Data; Muscimol; Naloxone; Naltrexone; Neurons, Afferent; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Opioid, mu; Spinal Cord | 1994 |
Immunologic characterization of TAT72-transgenic mice: effects of morphine on cell-mediated immunity.
Topics: Animals; Gene Products, tat; Immunity, Cellular; Immunosuppressive Agents; Interleukin-2; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Inbred DBA; Mice, Transgenic; Morphine; Naltrexone; Stereoisomerism; T-Lymphocytes, Cytotoxic | 1994 |
Assessment of endogenous enkephalins efficacy in the hot plate test in mice: comparative study with morphine.
Topics: Animals; Dose-Response Relationship, Drug; Enkephalins; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Receptors, Opioid, mu | 1995 |
Antinociceptive effect of dihydroetorphine in diabetic mice.
Topics: Analgesia; Analgesics, Opioid; Animals; Binding, Competitive; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Etorphine; Injections, Intraperitoneal; Injections, Intraventricular; Injections, Subcutaneous; Male; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Receptors, Opioid, delta; Receptors, Opioid, mu | 1995 |
Pretreatment with beta-funaltrexamine blocks morphine-mediated suppression of CTL activity in alloimmunized mice.
Topics: Animals; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Female; Immunization; In Vitro Techniques; Isoantigens; Killer Cells, Natural; Lymphocyte Activation; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Morphine; Naltrexone; Spleen; T-Lymphocytes, Cytotoxic | 1995 |
Effect of intracerebroventricular beta-funaltrexamine on mu opioid receptors in the rat brain: consideration of binding condition.
Topics: Analgesics; Animals; Binding, Competitive; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Tritium | 1995 |
mu-, delta- and kappa-opiate receptors mediate antinociception in the rat tail flick test following noxious thermal stimulation of one hindpaw.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Hindlimb; Hot Temperature; Male; Naltrexone; Narcotic Antagonists; Oligopeptides; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, Opioid | 1995 |
Effect of diabetes on the morphine-induced inhibition of gastrointestinal transit.
Topics: Animals; Depression, Chemical; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Gastrointestinal Transit; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Naltrexone | 1995 |
Characterisation of mu-opioid receptors on SH-SY5Y cells using naloxonazine and beta-funaltrexamine.
Topics: Amino Acid Sequence; Animals; Brain Neoplasms; Cerebral Cortex; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Humans; Ligands; Molecular Sequence Data; Naloxone; Naltrexone; Neuroblastoma; Rats; Receptors, Opioid, mu; Somatostatin; Tumor Cells, Cultured | 1994 |
Effects of diabetes on the morphine-induced Straub tail reaction in mice.
Topics: Animals; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred ICR; Morphine; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu; Reference Values; Tail | 1994 |
Central opioid receptor subtype mediation of isoproterenol-induced drinking in rats.
Topics: Animals; Drinking; Enkephalin, Leucine-2-Alanine; Injections, Intraventricular; Injections, Subcutaneous; Isoproterenol; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, mu | 1994 |
Morphine-induced straub tail response: mediated by central mu2-opioid receptor.
Topics: Analgesia; Animals; Female; Injections, Intraventricular; Male; Mice; Morphine; Naloxone; Naltrexone; Receptors, Opioid, mu; Tail | 1994 |
Delta-opiod receptor-mediated forced swimming stress-induced antinociception in the formalin test.
Topics: Animals; Formaldehyde; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Nociceptors; Pain Measurement; Receptors, Opioid, delta; Stress, Psychological; Swimming | 1993 |
Pharmacological analysis of the rate-decreasing effects of mu and kappa opioids in pigeons.
Topics: Animals; Columbidae; Conditioning, Operant; Dose-Response Relationship, Drug; Female; Naltrexone; Narcotic Antagonists; Narcotics; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reinforcement Schedule | 1994 |
Antagonism of the morphine-induced Straub tail reaction by kappa-opioid receptor activation in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Dose-Response Relationship, Drug; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Morphine; Naltrexone; Narcotic Antagonists; Pain Measurement; Pyrrolidines; Receptors, Opioid, kappa | 1993 |
Differential effects of systemically administered nor-binaltorphimine (nor-BNI) on kappa-opioid agonists in the mouse writhing assay.
Topics: Animals; Dose-Response Relationship, Drug; Injections, Subcutaneous; Male; Mice; Naltrexone; Narcotic Antagonists; Pain Measurement; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1994 |
Alkylation of mu opioid receptors by beta-funaltrexamine in vivo: comparison of the effects on in situ binding and heroin self-administration in rats.
Topics: Alkylation; Animals; Behavior, Animal; Binding, Competitive; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Heroin; In Vitro Techniques; Injections, Intraventricular; Naltrexone; Rats; Rats, Inbred F344; Receptors, Opioid, mu; Self Administration | 1995 |
Influence of hypertension development on rat tail artery responses to opioid peptides.
Topics: Age Factors; Animals; Dose-Response Relationship, Drug; Dynorphins; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Hypertension; In Vitro Techniques; Male; Naltrexone; Narcotic Antagonists; Phenylephrine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; Receptors, Opioid; Tail; Vasoconstriction | 1995 |
Differential regulation of adenylyl cyclase activity by mu and delta opioids in rat caudate putamen and nucleus accumbens.
Topics: Adenylyl Cyclases; Amino Acid Sequence; Animals; Benzeneacetamides; Caudate Nucleus; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Male; Molecular Sequence Data; Naloxone; Naltrexone; Nucleus Accumbens; Oligopeptides; Putamen; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Signal Transduction; Somatostatin | 1993 |
Inhibiting a spinal dynorphin A component enhances intrathecal morphine antinociception in mice.
Topics: Analgesics; Animals; Cerebral Ventricles; Dynorphins; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Spine | 1993 |
Mesolimbic dopamine neurotransmission is increased by administration of mu-opioid receptor antagonists.
Topics: Amino Acid Sequence; Animals; Dopamine; gamma-Aminobutyric Acid; Injections, Intraventricular; Male; Microdialysis; Molecular Sequence Data; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Rats; Rats, Inbred Strains; Receptors, Opioid, mu; Somatostatin; Ventral Tegmental Area | 1993 |
Etonitazene-induced antinociception in mu1 opioid receptor deficient CXBK mice: evidence for a role for mu2 receptors in supraspinal antinociception.
Topics: Animals; Benzimidazoles; Cerebral Ventricles; Dose-Response Relationship, Drug; Enkephalin, Leucine; Hot Temperature; Injections, Intraventricular; Injections, Subcutaneous; Male; Mice; Mice, Inbred ICR; Mice, Mutant Strains; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Receptors, Opioid, mu; Spinal Cord | 1994 |
Pharmacological characterization of dynorphin A (1-17)-induced effects on spinal cord-evoked potentials.
Topics: Animals; Drug Interactions; Dynorphins; Evoked Potentials; Ganglia, Spinal; Male; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Spinal Cord | 1994 |
Mu- and kappa-opioid receptors selectively reduce the same transient components of high-threshold calcium current in rat dorsal root ganglion sensory neurons.
Topics: Analgesics; Animals; Benzeneacetamides; Calcium; Calcium Channels; Dynorphins; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Evoked Potentials; Ganglia, Spinal; In Vitro Techniques; Naloxone; Naltrexone; Narcotic Antagonists; Neurons, Afferent; Pyrrolidines; Rats; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reference Values; Sensitivity and Specificity | 1994 |
Participation of opioid receptor types on post-tetanic twitch inhibition in isolated guinea-pig ileal longitudinal muscle.
Topics: Amino Acid Sequence; Animals; Dynorphins; Electric Stimulation; Enkephalin, Leucine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Molecular Sequence Data; Morphine; Muscle Contraction; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Narcotics; Peptide Fragments; Receptors, Opioid | 1994 |
Opioid peptides selective for receptor types modulate cocaine-induced behavioral responses in mice.
Topics: Animals; Behavior, Animal; Cocaine; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Naltrexone; Opioid Peptides | 1994 |
Differential modulation of behavioral responses by [D-Ala2, NMePhe4, Gly-ol]enkephalin, [D-Ala2] deltorphin II and [D-Pen2, L-Pen5]enkephalin in the mouse.
Topics: Analysis of Variance; Animals; Behavior, Animal; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Mice, Inbred Strains; Naltrexone; Oligopeptides | 1994 |
Beta-funaltrexamine blockade of opioid-induced inhibition of somatostatin secretion from rat stomach.
Topics: Amino Acid Sequence; Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Gastric Inhibitory Polypeptide; Gastric Mucosa; In Vitro Techniques; Male; Molecular Sequence Data; Naloxone; Naltrexone; Narcotic Antagonists; Radioimmunoassay; Rats; Rats, Wistar; Somatostatin | 1994 |
Antitussive effect of dihydroetorphine in mice.
Topics: Alkylating Agents; Animals; Antitussive Agents; Cough; Dose-Response Relationship, Drug; Etorphine; Injections, Intraperitoneal; Male; Mice; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1994 |
Antinociceptive and response rate-altering effects of kappa opioid agonists, spiradoline, enadoline and U69,593, alone and in combination with opioid antagonists in squirrel monkeys.
Topics: Analgesics; Animals; Azocines; Benzeneacetamides; Benzofurans; Dose-Response Relationship, Drug; Male; Morphine; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid, kappa; Saimiri | 1994 |
Streptozotocin-induced diabetes selectively reduces antinociception mediated by mu 1-opioid receptors, but not that mediated by mu 2-opioid receptors.
Topics: Analgesics; Animals; Diabetes Mellitus, Experimental; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Receptors, Opioid, mu; Spinal Cord | 1994 |
TRIMU-5, a mu 2-opioid receptor agonist, stimulates the hypothalamo-pituitary-adrenal axis.
Topics: Animals; Corticosterone; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hypothalamo-Hypophyseal System; Kinetics; Male; Naloxone; Naltrexone; Oligopeptides; Pituitary-Adrenal System; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 1994 |
Effects of diabetes on the antinociceptive effect of (+/-)pentazocine in mice.
Topics: Analgesics; Animals; Diabetes Mellitus, Experimental; Drug Synergism; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Nociceptors; Pentazocine; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1994 |
Multiple opiate receptor subtypes are involved in the stimulation of growth hormone release by beta-endorphin in female rats.
Topics: Animals; beta-Endorphin; Diestrus; Enkephalin, Leucine; Female; Growth Hormone; Kinetics; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1994 |
The use of specific opioid agonists and antagonists to delineate the vagally mediated antinociceptive and cardiovascular effects of intravenous morphine.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analysis of Variance; Animals; Blood Pressure; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Heart Rate; Hexamethonium; Hexamethonium Compounds; Indoles; Injections, Intravenous; Male; Morphinans; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pain; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reference Values; Time Factors; Vagotomy; Vagus Nerve | 1993 |
Effects of opioid receptors antagonists administration to suprachiasmatic nucleus on hibernation of ground squirrels Citellus dauricus.
Topics: Animals; Endorphins; Enkephalin, Leucine; Female; Hibernation; Injections; Male; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Sciuridae; Suprachiasmatic Nucleus | 1993 |
The effects of selective blockade of delta and mu opiate receptors on ethanol consumption by C57BL/6 mice in a restricted access paradigm.
Topics: Alcohol Drinking; Animals; Mice; Mice, Inbred C57BL; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Receptors, Opioid, mu | 1993 |
The effect of norbinaltorphimine, beta-funaltrexamine and naltrindole on NPY-induced feeding.
Topics: Animals; Eating; Injections, Intraventricular; Male; Naltrexone; Narcotic Antagonists; Neuropeptide Y; Rats; Rats, Sprague-Dawley | 1993 |
Characterization of the mu-opioid receptors on SH-SY5Y cells using beta-funaltrexamine (beta-FNA) and naloxonazine.
Topics: Analgesics; Cell Line; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Humans; Kinetics; Naloxone; Naltrexone; Narcotic Antagonists; Neuroblastoma; Receptors, Opioid, mu; Tumor Cells, Cultured | 1993 |
Antinociceptive effect of lipopolysaccharide from Pantoea agglomerans on streptozotocin-induced diabetic mice.
Topics: Analgesics; Animals; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Enterobacter; Injections, Subcutaneous; Lipopolysaccharides; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Pain Measurement | 1994 |
Differential modulation of angiotensin II and hypertonic saline-induced drinking by opioid receptor subtype antagonists in rats.
Topics: Angiotensin II; Animals; Drinking; Enkephalin, Leucine-2-Alanine; Male; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Saline Solution, Hypertonic | 1994 |
Influence of selective opiate antagonists on striatal acetylcholine and dopamine release.
Topics: Acetylcholine; Animals; Corpus Striatum; Dopamine; Electric Stimulation; In Vitro Techniques; Male; Naloxone; Naltrexone; Narcotic Antagonists; Oxidopamine; Rats; Rats, Wistar | 1993 |
The effect of selective opioid antagonists on butorphanol-induced feeding.
Topics: Animals; Butorphanol; Dose-Response Relationship, Drug; Feeding Behavior; Injections, Intraventricular; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1994 |
Antinociceptive effect of L-arginine in diabetic mice.
Topics: Analgesics; Animals; Arginine; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Endorphins; Injections, Intraventricular; Injections, Subcutaneous; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Nitroarginine; Pain Measurement; Reaction Time | 1994 |
Central kappa opioid receptor-evoked changes in renal function in conscious rats: participation of renal nerves.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Diuresis; Glomerular Filtration Rate; Heart Rate; Kidney; Male; Naltrexone; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sympathetic Nervous System | 1993 |
Effects of intracerebroventricular administration of beta-funaltrexamine on [3H]DAMGO binding to rat brain sections.
Topics: Animals; Autoradiography; Brain Mapping; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Injections, Intraventricular; Male; Naltrexone; Rats; Rats, Inbred F344; Receptors, Opioid, mu | 1993 |
Beta-[3H]funaltrexamine-labeled mu-opioid receptors: species variations in molecular mass and glycosylation by complex-type, N-linked oligosaccharides.
Topics: alpha-Mannosidase; Amidohydrolases; Animals; Brain; Cattle; Chromatography, Affinity; Corpus Striatum; Fluorometry; Glycosylation; Guinea Pigs; Mannosidases; Membranes; Mice; Molecular Weight; Naltrexone; Neuraminidase; Oligosaccharides; Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Solubility; Species Specificity; Tritium | 1993 |
Possible contribution of a glutathione conjugate to the long-duration action of beta-funaltrexamine.
Topics: Analgesia; Animals; Enkephalin, Leucine-2-Alanine; Glutathione; Guinea Pigs; Kinetics; Male; Mice; Morphine; Muscles; Naltrexone; Receptors, Opioid, mu; Structure-Activity Relationship; Vas Deferens | 1993 |
Medullary mu and delta opioid receptors modulate mesencephalic morphine analgesia in rats.
Topics: Analgesics; Animals; Male; Medulla Oblongata; Mesencephalon; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu | 1993 |
DAMGO ([D-Ala2,NMePhe4,Gly-ol]enkephalin), but not DPLPE ([D-Pen2,L- Pen5]enkephalin), specifically inhibits methamphetamine-induced behavioral responses in the mouse.
Topics: Analgesics; Animals; Behavior, Animal; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Methamphetamine; Mice; Mice, Inbred Strains; Naltrexone; Narcotic Antagonists | 1993 |
Sex differences in the antinociceptive effects of the enkephalinase inhibitor, SCH 34826.
Topics: Analgesia; Analgesics; Animals; Dioxolanes; Dipeptides; Enkephalin, Leucine; Female; Male; Naloxone; Naltrexone; Narcotic Antagonists; Neprilysin; Peromyscus; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Restraint, Physical; Sex Characteristics; Stress, Psychological | 1993 |
Naltrexone in vivo protects mu receptors from inactivation by beta-funaltrexamine, but not kappa receptors from inactivation by nor-binaltorphimine.
Topics: Analgesics; Animals; Benzeneacetamides; Cisterna Magna; Dose-Response Relationship, Drug; Injections; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain Measurement; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1993 |
Modification of morphine-induced locomotor activity by pertussis toxin: biochemical and behavioral studies in mice.
Topics: Analgesics; Analysis of Variance; Animals; Cerebral Ventricles; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intraventricular; Injections, Subcutaneous; Kinetics; Male; Mice; Mice, Inbred Strains; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Pertussis Toxin; Time Factors; Virulence Factors, Bordetella | 1993 |
Relative involvement of supraspinal and spinal mu opioid receptors in morphine dependence in mice.
Topics: Animals; Brain; Cerebral Ventricles; Diarrhea; Injections, Intraventricular; Injections, Spinal; Male; Mice; Morphine Dependence; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu; Spinal Cord; Substance Withdrawal Syndrome | 1993 |
Opioid antagonists and butorphanol dependence.
Topics: Animals; Behavior, Animal; Butorphanol; Indoles; Injections, Intraventricular; Male; Morphinans; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Substance Withdrawal Syndrome | 1993 |
Involvement of mu1 and mu2 opioid receptor subtypes in tail-pinch feeding in rats.
Topics: Animals; Arousal; Enkephalin, Leucine-2-Alanine; Feeding Behavior; Indoles; Male; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 1993 |
Independent expression of two pharmacologically distinct supraspinal mu analgesic systems in genetically different mouse strains.
Topics: Analgesia; Animals; Brain Stem; Drug Administration Routes; Male; Mice; Morphine; Naloxone; Naltrexone; Receptors, Opioid, mu; Species Specificity; Spinal Cord | 1993 |
Effect of antagonists selective for mu, delta and kappa opioid receptors on the reinforcing effects of heroin in rats.
Topics: Animals; Heroin; Male; Naloxone; Naltrexone; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Self Administration | 1993 |
CRF alters the infundibular LHRH secretory system from the medial preoptic area of female rats: possible involvement of opioid receptors.
Topics: Animals; Corticotropin-Releasing Hormone; Female; Gonadotropin-Releasing Hormone; Hypothalamus; Kinetics; Luteinizing Hormone; Naloxone; Naltrexone; Ovariectomy; Preoptic Area; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1993 |
Alpha-interferon inhibits adrenocortical secretion via mu 1-opioid receptors in the rat.
Topics: Animals; Corticosterone; Hypothalamo-Hypophyseal System; Injections, Intraperitoneal; Injections, Intraventricular; Interferon-alpha; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pituitary-Adrenal System; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Swimming | 1993 |
Mode of action of interleukin-1 in suppression of pituitary LH release in castrated male rats.
Topics: Animals; Corticotropin-Releasing Hormone; Depression, Chemical; Hypothalamus; Injections, Intraventricular; Interleukin-1; Luteinizing Hormone; Male; Naloxone; Naltrexone; Narcotic Antagonists; Orchiectomy; Pituitary Gland; Rats; Receptors, Opioid | 1993 |
Effects of kappa-agonist on the antinociception and locomotor enhancing action induced by morphine in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzylamines; Dopamine; Dose-Response Relationship, Drug; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Narcotics; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sympathomimetics | 1993 |
DAMGO stimulates the hypothalamo-pituitary-adrenal axis through a mu-2 opioid receptor.
Topics: Analgesics; Animals; Corticosterone; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hypothalamo-Hypophyseal System; Male; Naloxone; Naltrexone; Pituitary-Adrenal System; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 1993 |
Selective and interactive down-regulation of mu- and delta-opioid receptors in human neuroblastoma SK-N-SH cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Down-Regulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Humans; Morphine; Naltrexone; Neuroblastoma; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, mu; Tumor Cells, Cultured | 1993 |
The mixed antinociceptive agonist-antagonist activity of beta-endorphin(1-27) in mice.
Topics: Animals; Benzylidene Compounds; beta-Endorphin; Male; Mice; Naltrexone; Narcotic Antagonists; Nociceptors; Peptide Fragments; Receptors, Opioid | 1993 |
Central opioid receptor subtype antagonists differentially reduce intake of saccharin and maltose dextrin solutions in rats.
Topics: Animals; Drinking Behavior; Enkephalin, Leucine-2-Alanine; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Polysaccharides; Rats; Rats, Sprague-Dawley; Saccharin | 1993 |
Opiate receptor subtype involvement in the stimulation of prolactin release by beta-endorphin in female rats.
Topics: Animals; beta-Endorphin; Diestrus; Dose-Response Relationship, Drug; Enkephalin, Leucine; Female; Lactation; Male; Naltrexone; Narcotic Antagonists; Prolactin; Rats; Rats, Sprague-Dawley; Receptors, Opioid | 1993 |
Effects of beta-funaltrexamine treatment and sexual isolation in the perinatal period on the development of mu-opioid receptors and nociception.
Topics: Animals; Brain; Female; Male; Naltrexone; Narcotic Antagonists; Nociceptors; Rats; Rats, Wistar; Receptors, Opioid, mu; Sensory Thresholds; Sexual Maturation; Social Environment; Social Isolation | 1993 |
Antagonist effects of beta-funaltrexamine and naloxonazine on alfentanil-induced antinociception and muscle rigidity in the rat.
Topics: Alfentanil; Analgesia; Animals; Electromyography; Male; Muscle Rigidity; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar | 1993 |
Discriminative stimulus properties of morphine mediated by mu 1-opioid receptors.
Topics: Analgesics, Opioid; Animals; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred F344; Receptors, Opioid, mu | 1995 |
Opioid antagonists naloxone, beta-funaltrexamine and naltrindole, but not nor-binaltorphimine, reverse the increased hindpaw withdrawal latency in rats induced by intrathecal administration of the calcitonin gene-related peptide antagonist CGRP8-37.
Topics: Animals; Calcitonin Gene-Related Peptide; Hindlimb; Hot Temperature; Injections, Spinal; Male; Naloxone; Naltrexone; Narcotic Antagonists; Peptide Fragments; Rats; Rats, Sprague-Dawley; Reaction Time; Reflex; Stress, Mechanical | 1995 |
General, mu and kappa opioid antagonists in the nucleus accumbens alter food intake under deprivation, glucoprivic and palatable conditions.
Topics: Animals; Evaluation Studies as Topic; Feeding Behavior; Food Deprivation; Glucose; Male; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sucrose | 1995 |
Opioid antagonists and antisera to endogenous opioids increase the nociceptive response to formalin: demonstration of an opioid kappa and delta inhibitory tone.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Formaldehyde; Immune Sera; Male; Naloxone; Naltrexone; Narcotic Antagonists; Opioid Peptides; Pain; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa | 1996 |
Alkaloid delta agonist BW373U86 increases hypoxic tolerance.
Topics: Acute Disease; Animals; Benzamides; Body Temperature; Dose-Response Relationship, Drug; Hypoxia; Male; Mice; Mice, Inbred Strains; Naltrexone; Narcotic Antagonists; Piperazines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1996 |
Determination of the amino acid residue involved in [3H]beta-funaltrexamine covalent binding in the cloned rat mu-opioid receptor.
Topics: Amino Acid Sequence; Animals; CHO Cells; Chromatography, Affinity; Cloning, Molecular; Cricetinae; Hydrolysis; Lysine; Molecular Sequence Data; Mutagenesis, Site-Directed; Naltrexone; Protein Binding; Rats; Receptors, Opioid, mu; Tritium | 1996 |
Morphine stimulates phagocytosis of Mycobacterium tuberculosis by human microglial cells: involvement of a G protein-coupled opiate receptor.
Topics: Adjuvants, Immunologic; Brain; Cells, Cultured; Cholera Toxin; GTP-Binding Proteins; Humans; Microglia; Morphine; Mycobacterium tuberculosis; Naloxone; Naltrexone; Narcotic Antagonists; Neuroimmunomodulation; Pertussis Toxin; Phagocytosis; Receptors, Opioid; Signal Transduction; Virulence Factors, Bordetella | 1995 |
Intrastriatal injection of opioid receptor agonists inhibits apomorphine-induced behavior in 6-hydroxydopamine-treated mice.
Topics: Animals; Apomorphine; Behavior, Animal; Corpus Striatum; Dopamine; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Naltrexone; Oxidopamine; Peptide Fragments; Receptors, Opioid | 1995 |
Effects of beta-FNA on sympathoadrenal, cardiovascular, and analgesic responses to DAMPGO at rest and during stress.
Topics: Adrenal Glands; Analgesics; Animals; Blood Pressure; Catecholamines; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Heart Rate; Hemodynamics; Male; Naltrexone; Narcotic Antagonists; Organ Size; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Stress, Psychological; Sympathetic Nervous System | 1996 |
Role of opioid receptors in the spinal antinociceptive effects of neuropeptide FF analogues.
Topics: Amino Acid Sequence; Analgesics; Analgesics, Opioid; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Spinal; Male; Molecular Sequence Data; Morphine; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Somatostatin; Spinal Cord | 1996 |
Intrathecal Tyr-W-MIF-1 produces potent, naloxone-reversible analgesia modulated by alpha 2-adrenoceptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Amino Acid Sequence; Animals; Desipramine; Dose-Response Relationship, Drug; Injections, Spinal; Male; Mice; Molecular Sequence Data; MSH Release-Inhibiting Hormone; Naloxone; Naltrexone; Narcotic Antagonists; Norepinephrine; Receptors, Adrenergic, alpha-2; Yohimbine | 1996 |
Intraseptal microinjection of beta-funaltrexamine blocked a microwave-induced decrease of hippocampal cholinergic activity in the rat.
Topics: Animals; Choline; Cholinergic Fibers; Hippocampus; Male; Microinjections; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley | 1996 |
Reductions in locomotor activity following central opioid receptor subtype antagonists in rats.
Topics: Animals; Enkephalins; Locomotion; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley | 1996 |
Effects of selective opioid receptor antagonists on morphine-induced changes in striatal and limbic dopamine metabolism.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Dopamine; Homovanillic Acid; Injections, Intraperitoneal; Injections, Intraventricular; Limbic System; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pain Threshold; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu | 1995 |
The effects of morphine on carrageenin-induced spinal c-Fos expression are completely blocked by beta-funaltrexamine, a selective mu-opioid receptor antagonist.
Topics: Animals; Carrageenan; Gene Expression; Male; Morphine; Naltrexone; Narcotic Antagonists; Neurons; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Spinal Cord | 1996 |
Inhibition of tuberoinfundibular dopaminergic neural activity during suckling: involvement of mu and kappa opiate receptor subtypes.
Topics: 5-Hydroxytryptophan; Animals; Caudate Nucleus; Dihydroxyphenylalanine; Dopamine; Female; Hypothalamus, Anterior; Lactation; Male; Median Eminence; Naltrexone; Neurons; Preoptic Area; Prolactin; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Serotonin; Sucking Behavior | 1996 |
Differential effects of delta- and mu-opioid receptor antagonists on the amphetamine-induced increase in extracellular dopamine in striatum and nucleus accumbens.
Topics: Amphetamine; Analysis of Variance; Animals; Dopamine; Dopamine Agents; Dose-Response Relationship, Drug; Extracellular Space; Male; Microdialysis; Naltrexone; Narcotic Antagonists; Neostriatum; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu | 1996 |
Potential irreversible ligands for opioid receptors. Cinnamoyl derivatives of beta-naltrexamine.
Topics: Animals; Dose-Response Relationship, Drug; Guinea Pigs; Ileum; Male; Mice; Naltrexone; Narcotic Antagonists; Pain Measurement; Receptors, Opioid; Vas Deferens | 1996 |
Use of a mu-antisense oligodeoxynucleotide as a mu opioid receptor noncompetitive antagonist in vivo.
Topics: Animals; Base Sequence; Cerebral Ventricles; Injections, Intraventricular; Injections, Subcutaneous; Male; Molecular Sequence Data; Morphine; Naltrexone; Narcotic Antagonists; Oligonucleotides, Antisense; Pain; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid, mu | 1996 |
Modulation of humoral immune response by central administration of leucine-enkephalin: effects of mu, delta and kappa opioid receptor antagonists.
Topics: Adjuvants, Immunologic; Animals; Antibody Formation; Antibody-Producing Cells; Brain; Dose-Response Relationship, Drug; Enkephalin, Leucine; Hemolytic Plaque Technique; Injections, Intraventricular; Male; Naltrexone; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1996 |
Attenuation of memory with Tyr-D-Arg-Phe-beta-Ala-NH2, a novel dermorphin analog with high affinity for mu-opioid receptors.
Topics: Amino Acid Sequence; Analgesics, Opioid; Analysis of Variance; Animals; Avoidance Learning; Binding, Competitive; Drug Interactions; Injections, Intraventricular; Male; Mice; Molecular Sequence Data; Motor Activity; Naltrexone; Narcotic Antagonists; Oligopeptides; Opioid Peptides; Receptors, Opioid, mu | 1995 |
Different central opioid receptor subtype antagonists modify maltose dextrin and deprivation-induced water intake in sham feeding and sham drinking rats.
Topics: Animals; Dose-Response Relationship, Drug; Drinking; Eating; Enkephalin, Leucine-2-Alanine; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Polysaccharides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Water Deprivation | 1996 |
Potentiation of delta 9-tetrahydrocannabinol-induced analgesia by morphine in mice: involvement of mu- and kappa-opioid receptors.
Topics: Analgesia; Analgesics, Opioid; Animals; Binding Sites; Dronabinol; Drug Synergism; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Pain Measurement; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1996 |
Antidepressant-like effects of CCK(B) receptor antagonists: involvement of the opioid system.
Topics: Animals; Antidepressive Agents; Benzodiazepinones; Devazepide; Disulfides; Endorphins; Male; Mice; Naloxone; Naltrexone; Phenylalanine; Phenylurea Compounds; Receptor, Cholecystokinin A; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Sincalide | 1996 |
Nalbuphine coadministered with morphine prevents tolerance and dependence.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Therapy, Combination; Drug Tolerance; Male; Morphine; Nalbuphine; Naloxone; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Pyrrolidines; Rats; Rats, Sprague-Dawley | 1997 |
Inhibition of swine microglial cell phagocytosis of Cryptococcus neoformans by femtomolar concentrations of morphine.
Topics: Animals; Cryptococcus neoformans; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; GTP-Binding Proteins; Microglia; Morphine; Naltrexone; Narcotics; Phagocytosis; Swine | 1997 |
Central opioid receptors mediate glucoprivic inhibition of pituitary LH secretion.
Topics: Animals; Brain; Deoxyglucose; Glucose; Injections, Intravenous; Injections, Intraventricular; Luteinizing Hormone; Male; Naltrexone; Narcotic Antagonists; Orchiectomy; Pituitary Gland, Anterior; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, mu | 1997 |
5-HT spinal antinociception involves mu opioid receptors: cross tolerance and antagonist studies.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Electric Stimulation; Hot Temperature; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pain Threshold; Rats; Rats, Wistar; Receptors, Opioid, mu; Serotonin; Serotonin Antagonists; Spinal Cord | 1997 |
Antinociceptive effect of buprenorphine in mu1-opioid receptor deficient CXBK mice.
Topics: Animals; Buprenorphine; Male; Mice; Mice, Inbred C57BL; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu; Species Specificity | 1997 |
Antagonism of morphine-like discriminative effects by beta-funaltrexamine.
Topics: Analgesics, Opioid; Animals; Buprenorphine; Cisterna Magna; Discrimination Learning; Fentanyl; Injections; Male; Meperidine; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 1997 |
Butorphanol-mediated antinociception in mice: partial agonist effects and mu receptor involvement.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Butorphanol; Male; Mice; Morphine; Naltrexone; Pyrrolidines; Receptors, Opioid, mu | 1997 |
Antisense mapping of the MOR-1 opioid receptor clone: modulation of hyperphagia induced by DAMGO.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hyperphagia; Male; Naltrexone; Oligonucleotides, Antisense; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 1997 |
Interleukin-6 is differently modulated by central opioid receptor subtypes.
Topics: Animals; Cerebral Ventricles; Humans; Injections, Intraperitoneal; Injections, Intraventricular; Interleukin-1; Interleukin-6; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Proteins | 1997 |
Effects of intracerebroventricular administration of beta-funaltrexamine on DAMGO-stimulated [35S]GTP-gamma-S binding in rat brain sections.
Topics: Animals; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Injections, Intraventricular; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred F344; Receptors, Opioid, mu; Sulfur Radioisotopes | 1997 |
Evaluation of opioid receptor subtype antagonist effects in the ventral tegmental area upon food intake under deprivation, glucoprivic and palatable conditions.
Topics: Deoxyglucose; Eating; Enkephalin, Leucine-2-Alanine; Evaluation Studies as Topic; Food Deprivation; Hyperphagia; Insulin; Naltrexone; Narcotic Antagonists; Sucrose; Ventral Tegmental Area | 1997 |
Effects of Tyr-D-Arg-Phe-beta-Ala-NH2, a novel dermorphin analog, on elevated plus-maze learning and spontaneous alternation performance in mice.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Exploratory Behavior; Injections, Intraventricular; Male; Maze Learning; Memory; Mice; Mice, Inbred Strains; Naltrexone; Narcotic Antagonists; Oligopeptides; Opioid Peptides | 1997 |
Discriminative stimulus effects of the mixed-opioid agonist/antagonist dezocine: cross-substitution by mu and delta opioid agonists.
Topics: Analgesics, Opioid; Animals; Bridged Bicyclo Compounds, Heterocyclic; Columbidae; Cycloparaffins; Discrimination Learning; Female; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Receptors, Opioid, mu; Tetrahydronaphthalenes | 1997 |
Antinociceptive effects of (+)-matrine in mice.
Topics: Abdomen; Alkaloids; Analgesics; Animals; Male; Matrines; Mice; Mice, Inbred ICR; Muscle Contraction; Naltrexone; Narcotic Antagonists; Pain Measurement; Quinolizines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tail | 1997 |
Effect of mu opioid receptor blockade on alcohol intake in rats bred for high alcohol drinking.
Topics: Alcohol Drinking; Animals; Autoradiography; Gene Expression Regulation; Male; Naltrexone; Narcotic Antagonists; Pituitary Gland; Pro-Opiomelanocortin; Rats; Rats, Inbred Strains; Receptors, Opioid, mu; RNA, Messenger | 1998 |
Differential involvement of opioid receptors in intrathecal butorphanol-induced analgesia: compared to morphine.
Topics: Analgesics, Opioid; Animals; Butorphanol; Dose-Response Relationship, Drug; Injections, Spinal; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid | 1998 |
Ischemic preconditioning in the intact rat heart is mediated by delta1- but not mu- or kappa-opioid receptors.
Topics: Animals; Benzylidene Compounds; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hemodynamics; Ischemic Preconditioning, Myocardial; Male; Myocardial Infarction; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1998 |
A comparison of the effects of the opioid antagonists naltrexone, naltrindole, and beta-funaltrexamine on ethanol consumption in the rat.
Topics: Alcohol Drinking; Animals; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu | 1998 |
Opioids modulate the calcitonin gene-related peptide8-37-mediated hindpaw withdrawal latency increase in thermally injured rats.
Topics: Animals; Brain Chemistry; Burns; Calcitonin Gene-Related Peptide; Hindlimb; Injections, Spinal; Male; Mitogens; Naltrexone; Narcotic Antagonists; Nociceptors; Pain; Peptide Fragments; Pressure; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reflex | 1998 |
The role of subtypes of the opioid receptor in the anxiolytic action of chlordiazepoxide.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Chlordiazepoxide; Male; Mice; Naltrexone; Narcotic Antagonists; Receptors, Opioid | 1998 |
Beta-funaltrexamine discriminates between two subtypes of mu2-opioid receptors in electrically stimulated longitudinal muscle of guinea pig ileum.
Topics: Acetylcholine; Animals; Binding, Competitive; Electric Stimulation; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists; Nerve Endings; Receptors, Opioid, mu; Tetrodotoxin | 1998 |
Role of opioids in hypoxic pial artery dilation is stimulus duration dependent.
Topics: Animals; Arteries; Dynorphins; Enkephalin, Methionine; Female; Hypoxia, Brain; Male; Naltrexone; Narcotic Antagonists; Opioid Peptides; Pia Mater; Swine; Vasodilation | 1998 |
Involvement of mu- and delta-opioid receptors in the ethanol-associated place preference in rats exposed to foot shock stress.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Ethanol; Exploratory Behavior; Foot; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Morphine; Naloxone; Naltrexone; Narcotics; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu | 1998 |
Intracerebroventricular injection of mu- and delta-opiate receptor antagonists block 60 Hz magnetic field-induced decreases in cholinergic activity in the frontal cortex and hippocampus of the rat.
Topics: Animals; Cerebral Ventricles; Choline; Frontal Lobe; Hippocampus; Injections, Intraventricular; Magnetics; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Sodium | 1998 |
Effects of beta-funaltrexamine on dose-effect curves for heroin self-administration in rats: comparison with alteration of [3H]DAMGO binding to rat brain sections.
Topics: Analgesics, Opioid; Animals; Brain; Caudate Nucleus; Cocaine; Culture Techniques; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Heroin; Heroin Dependence; Motivation; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Radioligand Assay; Rats; Receptors, Opioid, mu; Self Administration | 1998 |
Ameliorative effects of tachykinins on scopolamine-induced impairment of spontaneous alternation performance in mice.
Topics: Animals; Male; Mice; Muscarinic Antagonists; Naloxone; Naltrexone; Narcotic Antagonists; Neurokinin A; Peptide Fragments; Psychomotor Performance; Scopolamine; Substance P; Tachykinins | 1998 |
The mu opioid irreversible antagonist beta-funaltrexamine differentiates the discriminative stimulus effects of opioids with high and low efficacy at the mu opioid receptor.
Topics: Animals; Buprenorphine; Butorphanol; Columbidae; Discrimination Learning; Female; Fentanyl; Levallorphan; Methadone; Morphine; Nalbuphine; Nalorphine; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu | 1998 |
Peripheral effects of opioids in a model of chronic intestinal inflammation in mice.
Topics: Animals; Antidiarrheals; Body Weight; Carbon Monoxide; Enteritis; Gastrointestinal Transit; Jejunum; Loperamide; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Receptors, Opioid | 1998 |
Effect of mu-selective opioid antagonists on MIP-1 beta and IL-1 beta-induced fever.
Topics: Animals; Body Temperature; Chemokine CCL4; Fever; Interleukin-1; Macrophage Inflammatory Proteins; Male; Naltrexone; Narcotic Antagonists; Peptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 1998 |
Heroin antinociception changed from mu to delta receptor in streptozotocin-treated mice.
Topics: Analgesics, Opioid; Animals; Anti-Bacterial Agents; Benzylidene Compounds; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Heroin; Injections, Intraventricular; Male; Mice; Morphine; Morphine Derivatives; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Pain; Receptors, Opioid, delta; Receptors, Opioid, mu; Streptozocin; Time Factors | 1998 |
Stereoselective mu- and delta-opioid receptor-related antinociception and binding with (+)-thebaine.
Topics: Analgesics; Animals; Binding, Competitive; Cells, Cultured; Epilepsy; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Pain Measurement; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Stereoisomerism; Thebaine | 1999 |
Dynorphin A increases substance P release from trigeminal primary afferent C-fibers.
Topics: Animals; Animals, Newborn; Capsaicin; Dizocilpine Maleate; Dynorphins; Enkephalin, Leucine; Excitatory Amino Acid Antagonists; In Vitro Techniques; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nerve Fibers; Neurons, Afferent; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Substance P; Trigeminal Nuclei | 1999 |
Endomorphin-like immunoreactivity in the rat dorsal horn and inhibition of substantia gelatinosa neurons in vitro.
Topics: Animals; Electrophysiology; Excitatory Postsynaptic Potentials; Female; Immunohistochemistry; In Vitro Techniques; Male; Naltrexone; Narcotic Antagonists; Neural Inhibition; Neurons; Oligopeptides; Rats; Rats, Sprague-Dawley; Spinal Cord; Substantia Gelatinosa | 1999 |
Spinal administration of selective opioid antagonists in amphibians: evidence for an opioid unireceptor.
Topics: Acetic Acid; Analgesics; Animals; Benzofurans; Female; Injections, Spinal; Male; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain Measurement; Pyrrolidines; Rana pipiens; Receptors, Opioid; Time Factors | 1999 |
Different roles of mu-, delta- and kappa-opioid receptors in ethanol-associated place preference in rats exposed to conditioned fear stress.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Behavior, Animal; Central Nervous System Depressants; Conditioning, Psychological; Ethanol; Fear; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stress, Psychological | 1999 |
Immunomodulatory action of class mu-, delta- and kappa-opioid receptor agonists in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Immunity; Lymphocyte Activation; Male; Mice; Mice, Inbred C57BL; Mitogens; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; T-Lymphocytes | 1998 |
Analgesia-producing mechanism of processed Aconiti tuber: role of dynorphin, an endogenous kappa-opioid ligand, in the rodent spinal cord.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Administration, Topical; Analgesics; Animals; Arcuate Nucleus of Hypothalamus; Cold Temperature; Dexamethasone; Dopamine Antagonists; Drugs, Chinese Herbal; Dynorphins; Glucocorticoids; Hypothalamus; Immune Sera; Ligands; Male; Mice; Naltrexone; Narcotic Antagonists; Nociceptors; Pain; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Salicylamides; Spinal Cord; Sulpiride | 1999 |
Roles of 5-HT3 and opioid receptors in the ethanol-induced place preference in rats exposed to conditioned fear stress.
Topics: Animals; Conditioning, Psychological; Ethanol; Fear; Male; Naltrexone; Ondansetron; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Stress, Psychological | 1999 |
Differential involvement of mu-opioid receptor subtypes in endomorphin-1- and -2-induced antinociception.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intraventricular; Injections, Spinal; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Oligopeptides; Pain; Receptors, Opioid, mu; Time Factors | 1999 |
Naltrexone and beta-funaltrexamine antagonism of the antinociceptive and response rate-decreasing effects of morphine, dezocine, and d-propoxyphene.
Topics: Animals; Dose-Response Relationship, Drug; Male; Naltrexone; Nociceptors; Pain; Rats | 1999 |
The effects of RB101, a mixed inhibitor of enkephalin-catabolizing enzymes, on carrageenin-induced spinal c-Fos expression are completely blocked by beta-funaltrexamine, a selective mu-opioid receptor antagonist.
Topics: Animals; Carrageenan; Disulfides; Enzyme Inhibitors; Male; Naltrexone; Narcotic Antagonists; Neprilysin; Phenylalanine; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Spinal Cord | 1999 |
Effects of mu and kappa opioid receptor antagonists on glucoprivic induction of Fos immunoreactivity in the rat preoptic area and hypothalamus.
Topics: Animals; Antimetabolites; Benzomorphans; Deoxyglucose; Glucose; Hypothalamus; Immunohistochemistry; Injections, Intraperitoneal; Injections, Intravenous; Male; Naltrexone; Narcotic Antagonists; Preoptic Area; Proto-Oncogene Proteins c-fos; Rats; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1999 |
Infusion of beta-FNA into the thalamus attenuates morphine-induced c-Fos induction in the rat caudate putamen.
Topics: Analgesics, Opioid; Animals; Caudate Nucleus; Infusions, Parenteral; Male; Morphine; Naltrexone; Narcotic Antagonists; Nerve Tissue Proteins; Proto-Oncogene Proteins c-fos; Putamen; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Thalamic Nuclei | 1999 |
Endomorphin-1 and endomorphin-2, endogenous ligands for the mu-opioid receptor, inhibit electrical activity of rat rostral ventrolateral medulla neurons in vitro.
Topics: Animals; Electrophysiology; Enkephalin, Methionine; In Vitro Techniques; Ligands; Male; Medulla Oblongata; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Nociceptin; Oligopeptides; Opioid Peptides; Perfusion; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 1999 |
Antinociceptive properties of FR140423 mediated through spinal delta-, but not mu- and kappa-, opioid receptors.
Topics: Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Binding, Competitive; Diarrhea; Injections, Intraventricular; Injections, Spinal; Male; Membranes; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Pyrazoles; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord; Sulfoxides | 1999 |
Role of the dorsal raphe nucleus in morphine-induced immediate early gene expression in the rat striatum.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Gene Expression; Genes, fos; Genes, Immediate-Early; Immunohistochemistry; Male; Morphine; Naltrexone; Narcotic Antagonists; Neostriatum; Periaqueductal Gray; Proto-Oncogene Proteins c-jun; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Serotonin | 1999 |
An interaction of opioids and galanin in dorsal horn of the spinal cord in mononeuropathic rats.
Topics: Animals; Galanin; Hindlimb; Injections, Spinal; Male; Mononeuropathies; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pain Measurement; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Spinal Cord | 2000 |
Analgesic effect of interferon-alpha via mu opioid receptor in the rat.
Topics: Analgesia; Animals; Antibodies, Monoclonal; Cell Line; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Leucine; Injections, Intraventricular; Interferon Type I; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Recombinant Proteins | 2000 |
The antinociceptive effects of endomorphin-1 and endomorphin-2 in diabetic mice.
Topics: Analgesics, Opioid; Animals; Diabetes Mellitus, Experimental; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Oligopeptides; Pain Measurement; Reaction Time; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2000 |
Lack of expression of long-term potentiation in the dentate gyrus but not in the CA1 region of the hippocampus of mu-opioid receptor-deficient mice.
Topics: Action Potentials; Animals; Corpus Striatum; Dentate Gyrus; Female; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Male; Mice; Mice, Mutant Strains; Naltrexone; Narcotic Antagonists; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Glutamate; Receptors, Opioid, mu; Synaptic Membranes | 2000 |
Enhancement of natural immunity seen after voluntary exercise in rats. Role of central opioid receptors.
Topics: Animals; Immunity, Innate; Injections, Intraventricular; Naltrexone; Narcotic Antagonists; Physical Conditioning, Animal; Rats; Receptors, Opioid | 2000 |
Inhibitory effect of intracerebroventricularly-administered [D-Arg(2), beta-Ala(4)]-dermorphin (1-4) on gastrointestinal transit.
Topics: Analgesics; Animals; Charcoal; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Female; Gastrointestinal Transit; Injections, Intraventricular; Mice; Mice, Inbred Strains; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides | 2000 |
Pharmacokinetic-pharmacodynamic modeling of the antinociceptive effects of main active metabolites of tramadol, (+)-O-desmethyltramadol and (-)-O-desmethyltramadol, in rats.
Topics: Algorithms; Analgesics, Opioid; Animals; Hydrogen-Ion Concentration; Male; Models, Biological; Naltrexone; Pain Measurement; Rats; Rats, Sprague-Dawley; Respiratory Mechanics; Stereoisomerism; Time Factors; Tramadol | 2000 |
Selective antagonism by naloxonazine of antinociception by Tyr-D-Arg-Phe-beta-Ala, a novel dermorphin analogue with high affinity at mu-opioid receptors.
Topics: Analgesics; Analgesics, Opioid; Animals; Drug Antagonism; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Injections, Intraventricular; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Opioid Peptides; Pain Measurement; Receptors, Opioid, mu; Time Factors | 2000 |
Effects of differential modulation of mu-, delta- and kappa-opioid systems on bicuculline-induced convulsions in the mouse.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Bicuculline; Brain Chemistry; Convulsants; Enkephalin, D-Penicillamine (2,5)-; Epilepsy, Tonic-Clonic; Injections, Intraventricular; Injections, Subcutaneous; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Quinolines; Receptors, GABA-A; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Seizures; Synaptic Transmission | 2000 |
Identification of the opioid receptors involved in passive-avoidance learning in the day-old chick during the second wave of neuronal activity.
Topics: Age Factors; Amnesia; Analgesics, Opioid; Animals; Anisomycin; Avoidance Learning; Brain Chemistry; Chickens; Chloramphenicol; Conditioning, Psychological; Dynorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Female; Male; Memory; Naltrexone; Narcotic Antagonists; Neurons; Nociceptin; Oligopeptides; Opioid Peptides; Protein Synthesis Inhibitors; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vasodilator Agents | 2000 |
Mercaptoacetate induces feeding through central opioid-mediated mechanisms in rats.
Topics: Animals; Antisense Elements (Genetics); Cloning, Molecular; Eating; Exons; Feeding Behavior; Injections, Intraperitoneal; Injections, Intraventricular; Locomotion; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stereotyped Behavior; Thioglycolates | 2000 |
Effects of endomorphins-1 and -2, endogenous mu-opioid receptor agonists, on spontaneous alternation performance in mice.
Topics: Analgesics, Opioid; Animals; Injections, Intraventricular; Male; Mice; Naltrexone; Narcotic Antagonists; Oligopeptides; Psychomotor Performance; Receptors, Opioid, mu | 2000 |
Selective opioid receptor agonist and antagonist displacement of [3H]naloxone binding in amphibian brain.
Topics: Animals; Binding, Competitive; Brain; Dose-Response Relationship, Drug; Kinetics; Naloxone; Naltrexone; Narcotic Antagonists; Radioligand Assay; Rana pipiens; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tritium | 2000 |
Reporter affinity labels: an o-phthalaldehyde derivative of beta-naltrexamine as a fluorogenic ligand for opioid receptors.
Topics: Affinity Labels; Animals; CHO Cells; Cricetinae; Ligands; Mice; Naltrexone; Narcotic Antagonists; o-Phthalaldehyde; Pain Measurement; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2000 |
Further characterization of the discriminative stimulus effects of spiradoline.
Topics: Analgesics, Non-Narcotic; Animals; Benzeneacetamides; Discrimination Learning; Drug Interactions; Male; Morphine; Naltrexone; Narcotic Antagonists; Nicotinic Antagonists; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Tetrahydronaphthalenes | 2000 |
Involvement of central opioid systems in human interferon-alpha induced immobility in the mouse forced swimming test.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Interferon-alpha; Interferon-beta; Interferon-gamma; Male; Mice; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Swimming; Time Factors | 2000 |
beta-Funaltrexamine inactivates ORL1 receptors in BE(2)-C human neuroblastoma cells.
Topics: Brain Neoplasms; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Humans; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Neuroblastoma; Nociceptin; Nociceptin Receptor; Opioid Peptides; Receptors, Opioid; Receptors, Opioid, mu; Tumor Cells, Cultured | 2000 |
Differential involvement of opioid receptors in stress-induced antinociception caused by repeated exposure to forced walking stress in mice.
Topics: Animals; Formaldehyde; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Receptors, Opioid; Stress, Physiological; Walking | 2000 |
Methocinnamox is a potent, long-lasting, and selective antagonist of morphine-mediated antinociception in the mouse: comparison with clocinnamox, beta-funaltrexamine, and beta-chlornaltrexamine.
Topics: Analgesics, Opioid; Animals; Binding, Competitive; Cerebral Cortex; Cinnamates; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Male; Mice; Morphine; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Pain Measurement; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2000 |
Pharmacokinetic-pharmacodynamic analysis of the EEG effect of alfentanil in rats following beta-funaltrexamine-induced mu-opioid receptor "knockdown" in vivo.
Topics: Alfentanil; Analgesics, Opioid; Animals; Electroencephalography; Male; Naltrexone; Narcotic Antagonists; Radioligand Assay; Rats; Rats, Wistar; Receptors, Opioid, mu | 2000 |
delta-Opioid receptors are more efficiently coupled to adenylyl cyclase than to L-type Ca(2+) channels in transfected rat pituitary cells.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Alkylating Agents; Analgesics, Opioid; Animals; Barium; Calcium Channels, L-Type; Enkephalin, D-Penicillamine (2,5)-; Fentanyl; Heterotrimeric GTP-Binding Proteins; Ion Channels; Naltrexone; Pituitary Gland; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Transfection; Virulence Factors, Bordetella | 2000 |
Dose- and time-dependent bimodal effects of kappa-opioid agonists on locomotor activity in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetamides; Animals; Benzomorphans; Dose-Response Relationship, Drug; Isothiocyanates; Male; Mice; Morphine; Motor Activity; Naloxone; Naltrexone; Receptors, Opioid, kappa; Time Factors | 2000 |
Activation of G-proteins in the mouse pons/medulla by beta-endorphin is mediated by the stimulation of mu- and putative epsilon-receptors.
Topics: Animals; beta-Endorphin; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; In Vitro Techniques; Kinetics; Male; Medulla Oblongata; Mice; Naltrexone; Narcotic Antagonists; Pons; Receptors, Opioid; Receptors, Opioid, mu; Sulfur Radioisotopes | 2000 |
Morphine inhibits human microglial cell production of, and migration towards, RANTES.
Topics: Brain; Calcium; Cells, Cultured; Chemokine CCL5; Chemotaxis; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Fetus; Humans; Interleukin-1; Lipopolysaccharides; Microglia; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Recombinant Proteins | 2000 |
Intestinal inflammation enhances the inhibitory effects of opioids on intestinal permeability in mice.
Topics: Analgesics, Opioid; Animals; Croton Oil; Dose-Response Relationship, Drug; Enteritis; Gastrointestinal Motility; Injections, Intraventricular; Intestinal Absorption; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Permeability; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, sigma | 2001 |
Role of PAG in the antinociception evoked from the medial or central amygdala in rats.
Topics: Adrenergic beta-Antagonists; Amygdala; Anesthetics, Local; Animals; Atropine; Electric Stimulation; Ganglionic Blockers; Lidocaine; Male; Mecamylamine; Methysergide; Microinjections; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Pain Threshold; Parasympatholytics; Periaqueductal Gray; Propranolol; Rats; Rats, Wistar; Serotonin Antagonists | 2001 |
Enadoline discrimination in squirrel monkeys: effects of opioid agonists and antagonists.
Topics: Animals; Benzofurans; Discrimination Learning; Dose-Response Relationship, Drug; Male; Nalbuphine; Naltrexone; Narcotic Antagonists; Pyrroles; Pyrrolidines; Receptors, Opioid, kappa; Receptors, Opioid, mu; Saimiri; Thiophenes | 2001 |
The role of minoxidil on endogenous opioid peptides in the spinal cord: a putative co-agonist relationship between K-ATP openers and opioids.
Topics: Adenosine Triphosphate; Animals; Dose-Response Relationship, Drug; Male; Minoxidil; Naltrexone; Narcotic Antagonists; Nociceptors; Opioid Peptides; Pain; Potassium Channels; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Spinal Cord; Vasodilator Agents | 2001 |
Beta-endorphin-induced feeding: pharmacological characterization using selective opioid antagonists and antisense probes in rats.
Topics: Analgesics, Opioid; Animals; Antisense Elements (Genetics); beta-Endorphin; Cloning, Molecular; Dose-Response Relationship, Drug; Eating; Exons; Feeding Behavior; Male; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta | 2001 |
Pharmacological characterization of the dermorphin analog [Dmt(1)]DALDA, a highly potent and selective mu-opioid peptide.
Topics: Analgesics; Animals; Drug Tolerance; Humans; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Oligodeoxyribonucleotides, Antisense; Oligopeptides; Opioid Peptides; Pain Measurement; Receptors, Opioid, mu; Time Factors | 2001 |
Endomorphins 1 and 2, endogenous mu-opioid receptor agonists, impair passive avoidance learning in mice.
Topics: Analgesics, Opioid; Animals; Avoidance Learning; Behavior, Animal; Dose-Response Relationship, Drug; Male; Mice; Naltrexone; Narcotic Antagonists; Oligopeptides; Receptors, Opioid, mu | 2001 |
Stimulation of guanosine-5'-o-(3-[35S]thio)triphosphate binding in digitonin-permeabilized C6 rat glioma cells: evidence for an organized association of mu-opioid receptors and G protein.
Topics: Analgesics, Opioid; Animals; Digitonin; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Glioma; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Indicators and Reagents; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Receptors, Opioid, mu; Tumor Cells, Cultured | 2001 |
gamma-Aminobutyric acid receptor subtype antagonists differentially alter opioid-induced feeding in the shell region of the nucleus accumbens in rats.
Topics: Animals; Baclofen; Bicuculline; Eating; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; GABA Agonists; GABA Antagonists; GABA-A Receptor Antagonists; GABA-B Receptor Antagonists; gamma-Aminobutyric Acid; Male; Naltrexone; Narcotic Antagonists; Narcotics; Neurons; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, GABA; Receptors, GABA-A; Receptors, GABA-B; Receptors, Opioid | 2001 |
Inhibition of neuropathic pain by selective ablation of brainstem medullary cells expressing the mu-opioid receptor.
Topics: Animals; Behavior, Animal; Brain Stem; Disease Models, Animal; Immunotoxins; Ligation; Male; Medulla Oblongata; Microinjections; N-Glycosyl Hydrolases; Naltrexone; Neuralgia; Neurons; Oligopeptides; Opioid Peptides; Pain Measurement; Physical Stimulation; Plant Proteins; Radioligand Assay; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid, mu; Recombinant Fusion Proteins; Ribosome Inactivating Proteins, Type 1; Saporins; Spinal Nerves | 2001 |
Lack of the involvement of mu1-opioid receptor subtype on motivational effects induced by the endogenous mu-opioid receptor ligands endomorphin-1 and -2 in the mouse.
Topics: Analgesics, Opioid; Animals; Binding Sites; Brain; Cell Membrane; Conditioning, Psychological; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice; Mice, Inbred C57BL; Motivation; Naltrexone; Narcotic Antagonists; Neurons; Oligopeptides; Radioligand Assay; Receptors, Opioid, mu; Subcellular Fractions; Sulfur Radioisotopes; Ventral Tegmental Area | 2001 |
Constitutively active mu-opioid receptors inhibit adenylyl cyclase activity in intact cells and activate G-proteins differently than the agonist [D-Ala2,N-MePhe4,Gly-ol5]enkephalin.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Cell Line; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; GTP-Binding Proteins; Naltrexone; Potassium Chloride; Protein Binding; Receptors, Opioid, mu; Virulence Factors, Bordetella | 2001 |
Effects of endomorphin-2 on arterial blood pressure and pain threshold in spontaneously hypertensive rats and modification of these effects by beta-funaltrexamine and nor-binaltorphimine.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Blood Pressure; Disease Models, Animal; Drug Interactions; Male; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain; Pain Threshold; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 2001 |
The effect of the leucopyrokinin analogue: [2-8]-leucopyrokinin on central opioid receptors in rats.
Topics: Analgesia; Analgesics; Animals; Dose-Response Relationship, Drug; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Oligopeptides; Peptide Fragments; Rats; Rats, Wistar; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tail; Time Factors | 2001 |
Endomorphin-1 improves scopolamine-induced impairment of short-term memory via mu1-opioid receptor in mice.
Topics: Analgesics, Opioid; Animals; Brain; Dose-Response Relationship, Drug; Drug Interactions; Male; Maze Learning; Memory Disorders; Memory, Short-Term; Mice; Muscarinic Antagonists; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Oligopeptides; Receptors, Opioid, mu; Scopolamine | 2001 |
Immunomodulation by opioid peptidomimetic compound.
Topics: Animals; Cells, Cultured; Humans; Leukocytes, Mononuclear; Macrophages; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Neuroimmunomodulation; Nitric Oxide; Opioid Peptides; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Tumor Necrosis Factor-alpha | 2001 |
Analysis of opioid receptor subtype antagonist effects upon mu opioid agonist-induced feeding elicited from the ventral tegmental area of rats.
Topics: Animals; Appetite Regulation; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Feeding Behavior; Male; Naltrexone; Narcotic Antagonists; Narcotics; Neural Pathways; Neurons; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Synaptic Transmission; Ventral Tegmental Area | 2002 |
Dynorphin A(1-17)-induced feeding: pharmacological characterization using selective opioid antagonists and antisense probes in rats.
Topics: Animals; Dose-Response Relationship, Drug; Drug Interactions; Dynorphins; Feeding Behavior; Male; Models, Animal; Naltrexone; Narcotic Antagonists; Oligonucleotides, Antisense; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2002 |
Differential involvement of mu-opioid receptors in the rostral versus caudal nucleus accumbens in the reinforcing effects of heroin in rats: evidence from focal injections of beta-funaltrexamine.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Heroin; Injections, Intraventricular; Male; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Rats; Rats, Inbred F344; Receptors, Opioid, mu; Reinforcement, Psychology; Self Administration | 2002 |
Anti-nociceptive effect of neuropeptide Y in the nucleus accumbens of rats: an involvement of opioid receptors in the effect.
Topics: Animals; Catheterization; Dose-Response Relationship, Drug; Hot Temperature; Male; Microinjections; Naloxone; Naltrexone; Narcotic Antagonists; Neuropeptide Y; Nucleus Accumbens; Pain Measurement; Peptide Fragments; Physical Stimulation; Rats; Rats, Wistar; Receptors, Neuropeptide Y; Receptors, Opioid | 2002 |
Involvement of endogenous opioid systems in nociceptin-induced spinal antinociception in rats.
Topics: Animals; Endorphins; Hindlimb; Hot Temperature; Injections, Spinal; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptin; Nociceptors; Opioid Peptides; Pain; Pain Measurement; Peptide Fragments; Physical Stimulation; Rats; Rats, Sprague-Dawley; Spinal Cord | 2002 |
Possible involvement of mu1-opioid receptors in the fentanyl- or morphine-induced antinociception at supraspinal and spinal sites.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Fentanyl; Injections, Intraventricular; Injections, Spinal; Injections, Subcutaneous; Male; Mice; Mice, Inbred C57BL; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Receptors, Opioid, mu; Spinal Cord | 2002 |
Effects of opioid antagonists on unconditioned and conditioned hyperactivity to morphine.
Topics: Analgesics, Opioid; Animals; Conditioning, Operant; Dose-Response Relationship, Drug; Hyperkinesis; Male; Morphine; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2002 |
Involvement of the opioid system in the anxiolytic-like effects induced by Delta(9)-tetrahydrocannabinol.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Darkness; Dronabinol; Endorphins; Light; Male; Mice; Naltrexone; Narcotic Antagonists; Piperidines; Pyrazoles; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Rimonabant | 2002 |
Different effects of methionine-enkephalin on paw edema in two inbred rat strains.
Topics: Animals; Dexamethasone; Dose-Response Relationship, Drug; Edema; Enkephalin, Methionine; Glucocorticoids; Inflammation; Kinetics; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Species Specificity; Time Factors | 2002 |
Morphine regulates gene expression of alpha- and beta-chemokines and their receptors on astroglial cells via the opioid mu receptor.
Topics: Adjuvants, Immunologic; Astrocytes; Astrocytoma; Cells, Cultured; Chemokine CCL4; Chemokines, CC; Chemokines, CXC; Down-Regulation; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Humans; Immunophenotyping; Interleukin-8; Macrophage Inflammatory Proteins; Morphine; Naltrexone; Receptors, CCR3; Receptors, CCR5; Receptors, Chemokine; Receptors, Interleukin-8B; Receptors, Opioid, mu; Tumor Cells, Cultured; Up-Regulation | 2002 |
Quantitative stoichiometry of G-proteins activated by mu-opioid receptors in postmortem human brain.
Topics: Alkylation; Analgesics, Opioid; Baclofen; Binding, Competitive; Brain Chemistry; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enzyme Inhibitors; Ethylmaleimide; GABA Agonists; GTP-Binding Protein Regulators; GTP-Binding Proteins; Humans; In Vitro Techniques; Kinetics; Membranes; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu; Signal Transduction | 2002 |
Opioid receptor subtypes differentially modulate serotonin efflux in the rat central nervous system.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Central Nervous System; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Male; Microdialysis; Microinjections; Naltrexone; Nucleus Accumbens; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Serotonin | 2002 |
Combined blockade of both micro - and kappa-opioid receptors prevents the acute orexigenic action of Agouti-related protein.
Topics: Agouti-Related Protein; Animals; Drug Interactions; Eating; Male; Naltrexone; Narcotic Antagonists; Peptide Fragments; Rats; Rats, Long-Evans; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2002 |
Functional interactions between delta- and mu-opioid receptors in rat thermoregulation.
Topics: Animals; Body Temperature; Body Temperature Regulation; Dose-Response Relationship, Drug; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptor Cross-Talk; Receptors, Opioid, delta; Receptors, Opioid, mu | 2003 |
Effects of beta-funaltrexamine and naloxonazine on single-trial morphine-conditioned place preference and locomotor activity.
Topics: Animals; Conditioning, Psychological; Male; Morphine; Motor Activity; Naloxone; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 2003 |
Opioid receptor antagonists modulate Ca2+-activated K+ channels in mesenteric arterial smooth muscle cells of rats in hemorrhagic shock.
Topics: Animals; Calcium; Dose-Response Relationship, Drug; Down-Regulation; Electrophysiology; Kinetics; Membrane Potentials; Mesenteric Arteries; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Naloxone; Naltrexone; Narcotic Antagonists; Potassium Channels; Rats; Rats, Wistar; Shock, Hemorrhagic | 2003 |
Sufentanil-related respiratory depression and antinociception in the dog. Mediation by different receptor types.
Topics: Analgesics, Opioid; Animals; Blood Gas Analysis; Depression, Chemical; Dogs; Dose-Response Relationship, Drug; Evoked Potentials; Injections, Intraventricular; Male; Naltrexone; Narcotic Antagonists; Neurons, Afferent; Oxygen; Oxygen Consumption; Receptors, Opioid, delta; Receptors, Opioid, mu; Sufentanil | 2002 |
Opioid receptor subtypes involved in the regulation of prolactin secretion during pregnancy and lactation.
Topics: Animals; Female; Injections, Intraventricular; Lactation; Naltrexone; Narcotic Antagonists; Pituitary Gland; Pregnancy; Pregnancy, Animal; Prolactin; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2003 |
Use of irreversible antagonists to determine the relative efficacy of mu-opioids in a pigeon drug discrimination procedure: comparison of beta-funaltrexamine and clocinnamox.
Topics: Animals; Cinnamates; Columbidae; Female; Fentanyl; Methadone; Morphine; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Narcotics; Reaction Time; Receptors, Opioid, mu; Sufentanil | 2003 |
Nifedipine potentiates the antinociceptive effect of endomorphin-1 microinjected into the periaqueductal gray in rats.
Topics: Analgesics, Opioid; Animals; Area Under Curve; Behavior, Animal; Calcium Channel Blockers; Dose-Response Relationship, Drug; Male; Microinjections; Naltrexone; Narcotic Antagonists; Nifedipine; Oligopeptides; Pain Measurement; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Reaction Time | 2003 |
Effects of heroin and its metabolites on schedule-controlled responding and thermal nociception in rhesus monkeys: sensitivity to antagonism by quadazocine, naltrindole and beta-funaltrexamine.
Topics: Animals; Azocines; Behavior, Animal; Dose-Response Relationship, Drug; Food; Heroin; Hot Temperature; Macaca mulatta; Morphine; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Pain Measurement | 2003 |
The antitussive effects of endomorphin-1 and endomorphin-2 in mice.
Topics: Animals; Antitussive Agents; Capsaicin; Cough; Dose-Response Relationship, Drug; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Oligopeptides; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2003 |
beta-Funaltrexamine, a gauge for the recognition site of wildtype and mutant H297Q mu-opioid receptors.
Topics: Animals; COS Cells; Dose-Response Relationship, Drug; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Guanosine 5'-O-(3-Thiotriphosphate); Membrane Potentials; Morphine Derivatives; Mutation; Naltrexone; Narcotic Antagonists; Oocytes; Patch-Clamp Techniques; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Opioid, mu; Transfection; Xenopus | 2003 |
Buprenorphine blocks epsilon- and micro-opioid receptor-mediated antinociception in the mouse.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; beta-Endorphin; Buprenorphine; Disease Models, Animal; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Time Factors | 2003 |
Agonist/antagonist properties of nalbuphine, butorphanol and (-)-pentazocine in male vs. female rats.
Topics: Animals; Benzeneacetamides; Butorphanol; Diuresis; Diuretics; Dose-Response Relationship, Drug; Female; Male; Nalbuphine; Naltrexone; Narcotic Antagonists; Pentazocine; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sex Characteristics; Urination | 2003 |
Morphine withdrawal precipitated by specific mu, delta or kappa opioid receptor antagonists: a c-Fos protein study in the rat central nervous system.
Topics: Animals; Behavior, Animal; Cell Count; Central Nervous System; Gene Expression Regulation; Immunohistochemistry; Male; Morphine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Narcotics; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 2003 |
Neuroprotection of naloxone against ischemic injury in rats: role of mu receptor antagonism.
Topics: Animals; Carotid Artery, Common; Cerebral Infarction; Coronary Disease; Functional Laterality; Hypoxia-Ischemia, Brain; Infarction, Middle Cerebral Artery; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Time Factors | 2003 |
Beta-funaltrexamine affects cocaine self-administration in rats responding on a progressive ratio schedule of reinforcement.
Topics: Animals; Cocaine; Conditioning, Operant; Male; Microinjections; Naltrexone; Narcotic Antagonists; Neostriatum; Nucleus Accumbens; Rats; Rats, Inbred F344; Reinforcement Schedule; Self Administration; Ventral Tegmental Area | 2003 |
Possible antinociceptive mechanisms of opioid receptor antagonists in the mouse formalin test.
Topics: 5,7-Dihydroxytryptamine; Animals; Behavior, Animal; Benzylamines; Formaldehyde; Injections, Intraperitoneal; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Pain Measurement; Receptors, Opioid, delta; Receptors, Opioid, mu | 2003 |
Endomorphin-1, an endogenous mu-opioid receptor agonist, improves apomorphine-induced impairment of prepulse inhibition in mice.
Topics: Animals; Apomorphine; Male; Mice; Naltrexone; Oligopeptides; Receptors, Opioid, mu; Reflex, Startle | 2003 |
Involvement of oxytocin in spinal antinociception in rats with inflammation.
Topics: Analgesics; Animals; Carrageenan; Hot Temperature; Inflammation; Injections, Spinal; Male; Naloxone; Naltrexone; Narcotic Antagonists; Oxytocin; Pain; Pain Measurement; Physical Stimulation; Rats; Rats, Wistar; Spinal Cord; Vasotocin | 2003 |
Morphine enhances hepatitis C virus (HCV) replicon expression.
Topics: Antiviral Agents; Enzyme Activation; Gene Expression; Hepacivirus; Humans; Interferon-alpha; Morphine; Naltrexone; Narcotic Antagonists; NF-kappa B; Receptors, Opioid, mu; Replicon; RNA, Messenger; Tumor Cells, Cultured | 2003 |
An opioid basis for early-phase isoflurane-induced hypotension in rats.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Antibodies, Blocking; beta-Endorphin; Blood Pressure; Endorphins; Enkephalin, Methionine; Hot Temperature; Hypotension; Injections, Intraventricular; Isoflurane; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid; Urethane | 2003 |
Involvement of central mu-opioid system in the scratching behavior in mice, and the suppression of it by the activation of kappa-opioid system.
Topics: Animals; Antipruritics; Behavior, Animal; Injections, Intraventricular; Injections, Subcutaneous; Ketotifen; Male; Mice; Morphinans; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Pruritus; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spiro Compounds; Substance P | 2003 |
Effects of endomorphin on substantia gelatinosa neurons in rat spinal cord slices.
Topics: Animals; Bicuculline; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Excitatory Postsynaptic Potentials; Female; Male; Membrane Potentials; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Oligopeptides; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Spinal Cord; Substantia Gelatinosa; Tetrodotoxin; Time Factors | 2003 |
Interrelationships between mu opioid and melanocortin receptors in mediating food intake in rats.
Topics: Animals; beta-Endorphin; Body Weight; Dose-Response Relationship, Drug; Eating; Male; Melanocyte-Stimulating Hormones; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Melanocortin; Receptors, Opioid, mu | 2003 |
Effects of beta-casomorphin-5 on passive avoidance response in mice.
Topics: Analgesics; Animals; Avoidance Learning; Cerebral Ventricles; Endorphins; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Naltrexone; Narcotic Antagonists; Peptide Fragments; Reaction Time; Scopolamine | 2003 |
Mu opioid control of the N-methyl-D-aspartate-evoked release of [3H]-acetylcholine in the limbic territory of the rat striatum in vitro: diurnal variations and implication of a dopamine link.
Topics: Acetylcholine; Animals; Circadian Rhythm; Corpus Striatum; Dopamine; Limbic System; Male; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, mu; Tritium | 2004 |
Sex differences in opioid-induced enhancement of contact hypersensitivity.
Topics: Animals; Buprenorphine; Castration; Dermatitis, Contact; Etorphine; Female; Gonadal Steroid Hormones; Male; Morphine; Naltrexone; Rats; Rats, Inbred F344; Receptors, Opioid, mu; Sex Characteristics | 2003 |
Effects of chronic administration of PL017 and beta-funaltrexamine hydrochloride on susceptibility of kainic acid-induced seizures in rats.
Topics: Animals; Disease Susceptibility; Dynorphins; Epilepsy; Hippocampus; Kainic Acid; Male; Naltrexone; Peptide Fragments; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 2004 |
Opioid receptor antagonists increase [Ca2+]i in rat arterial smooth muscle cells in hemorrhagic shock.
Topics: Animals; Calcium; Cell Separation; Mesenteric Arteries; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Shock, Hemorrhagic | 2004 |
Kinetics of beta-funaltrexamine binding to wild-type and mutant mu-opioid receptors expressed in Chinese hamster ovary cells.
Topics: Animals; CHO Cells; Cricetinae; Gene Expression Regulation; Mutation; Naltrexone; Protein Binding; Receptors, Opioid, mu | 2004 |
Role of hippocampal CA3 mu-opioid receptors in spatial learning and memory.
Topics: Animals; Autoradiography; Binding, Competitive; Catheterization; Hippocampus; Male; Maze Learning; Memory; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Retention, Psychology; Reversal Learning | 2004 |
Supraspinal and spinal cord opioid receptors are responsible for antinociception following intrathecal morphine injections.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Injections, Spinal; Male; Models, Animal; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Pain; Pain Threshold; Random Allocation; Rats; Rats, Wistar; Reaction Time; Receptors, Opioid; Spinal Cord; Tail | 2004 |
Involvement of opioid receptors in the oxytocin-induced antinociception in the central nervous system of rats.
Topics: Animals; Central Nervous System; Male; Naloxone; Naltrexone; Narcotic Antagonists; Oxytocin; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2004 |
Opposite conditioned place preference responses to endomorphin-1 and endomorphin-2 in the mouse.
Topics: Animals; Azocines; Conditioning, Operant; Injections, Intraventricular; Ligands; Male; Mice; Naltrexone; Oligopeptides; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2004 |
Estrogen and mu-opioid receptor antagonists counteract the 17 beta-estradiol-induced licking increase and interferon-gamma reduction occurring during the formalin test in male rats.
Topics: Animals; Behavior, Animal; Drug Interactions; Estradiol; Estrogen Antagonists; Fulvestrant; Injections, Intraventricular; Interferon-gamma; Male; Naltrexone; Narcotic Antagonists; Neuroimmunomodulation; Pain; Pain Measurement; Rats; Rats, Wistar; Receptors, Opioid, mu | 2004 |
Opioid receptors and acetaminophen (paracetamol).
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Dynorphins; Endorphins; Enkephalins; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2004 |
Interactions of galanin and opioids in nociceptive modulation in the arcuate nucleus of hypothalamus in rats.
Topics: Analgesics, Opioid; Animals; Arcuate Nucleus of Hypothalamus; Dose-Response Relationship, Drug; Galanin; Hindlimb; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Pain; Rats; Rats, Wistar; Receptors, Opioid | 2005 |
A Tyr-W-MIF-1 analog containing D-Pro2 acts as a selective mu2-opioid receptor antagonist in the mouse.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Male; Mice; MSH Release-Inhibiting Hormone; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Receptors, Opioid, mu | 2005 |
Differentiation of opioid receptor preference by [Dmt1]endomorphin-2-mediated antinociception in the mouse.
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Hot Temperature; Injections, Intraventricular; Injections, Subcutaneous; Male; Mice; Naloxone; Naltrexone; Nociceptors; Oligopeptides; Pain; Pain Measurement; Receptors, Opioid, delta; Receptors, Opioid, mu; Tail; Time Factors | 2005 |
Involvement of the opioid system in the effects induced by nicotine on anxiety-like behaviour in mice.
Topics: Analysis of Variance; Animals; Anxiety Disorders; Behavior, Animal; Dose-Response Relationship, Drug; Drug Antagonism; Drug Synergism; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Maze Learning; Mecamylamine; Mice; Naltrexone; Narcotic Antagonists; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Receptors, Opioid | 2005 |
Functional mu opioid receptors are expressed in cholinergic interneurons of the rat dorsal striatum: territorial specificity and diurnal variation.
Topics: Acetylcholine; Analgesics, Opioid; Animals; Blotting, Northern; Choline O-Acetyltransferase; Circadian Rhythm; Corpus Striatum; Drug Interactions; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Excitatory Amino Acid Agonists; Immunohistochemistry; In Vitro Techniques; Interneurons; Limbic System; Membrane Potentials; N-Methylaspartate; Naltrexone; Narcotic Antagonists; Patch-Clamp Techniques; Potassium; Protein Precursors; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Synaptosomes; Tritium | 2005 |
Effects of opioid antagonists and morphine in a hippocampal hypoxia/hypoglycemia model.
Topics: Analgesics, Opioid; Animals; Brain Chemistry; Evoked Potentials; Hippocampus; Hypoglycemia; Hypoxia, Brain; In Vitro Techniques; Male; Morphine; Naltrexone; Narcotic Antagonists; Neuroprotective Agents; Neurotoxicity Syndromes; Rats; Rats, Wistar; Reperfusion Injury | 2005 |
Pharmacological study on the novel antinociceptive agent, a novel monoterpene alkaloid from Incarvillea sinensis.
Topics: Alkaloids; Analgesics; Bignoniaceae; Monoterpenes; Naltrexone; Narcotic Antagonists; Purinergic P1 Receptor Antagonists | 2005 |
Antinociceptive effect of oxycodone in diabetic mice.
Topics: Analgesics, Opioid; Animals; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Narcotic Antagonists; Oxycodone; Pain; Pain Measurement; Time Factors | 2005 |
Antinociceptive effect of shakuyakukanzoto, a Kampo medicine, in diabetic mice.
Topics: Adrenergic alpha-Antagonists; Analgesics; Animals; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Drug Combinations; Drugs, Chinese Herbal; Glycyrrhiza; Male; Medicine, Kampo; Methysergide; Mice; Naltrexone; Narcotic Antagonists; Oxidopamine; Paeonia; Pain Measurement; Pain Threshold; Piperazines; Serotonin Antagonists; Sympatholytics; Tropanes; Yohimbine | 2005 |
Effects of systemic administration of beta-casomorphin-5 on learning and memory in mice.
Topics: Analgesics; Animals; Avoidance Learning; Cattle; Dose-Response Relationship, Drug; Endorphins; Injections, Intraperitoneal; Injections, Intraventricular; Injections, Subcutaneous; Male; Memory; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Peptide Fragments; Receptors, Opioid, mu; Scopolamine | 2006 |
mu- but not delta- and kappa-opioid receptor mediates the nucleus submedius interferon-alpha-evoked antinociception in the rat.
Topics: Animals; Escape Reaction; Interferon-alpha; Male; Mediodorsal Thalamic Nucleus; Microinjections; Naloxone; Naltrexone; Pain; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2006 |
Involvements of mu- and kappa-opioid receptors in morphine-induced antinociception in the nucleus accumbens of rats.
Topics: Analgesics, Opioid; Animals; Male; Morphine; Naloxone; Naltrexone; Nucleus Accumbens; Pain; Physical Stimulation; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2006 |
Characterization of the antinociceptive effects of oxycodone in diabetic mice.
Topics: Analgesics, Opioid; Animals; Area Under Curve; Diabetes Mellitus, Experimental; Injections, Intraventricular; Injections, Spinal; Injections, Subcutaneous; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Oxycodone; Pain; Pain Measurement; Streptozocin | 2006 |
Mu-opioid receptor cellular function in the nucleus accumbens is essential for hedonically driven eating.
Topics: Analgesics, Opioid; Animals; Autoradiography; Eating; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Food Preferences; Guanosine 5'-O-(3-Thiotriphosphate); Male; Microinjections; Naltrexone; Nucleus Accumbens; Peptide Fragments; Peptides; Rabbits; Receptors, G-Protein-Coupled; Receptors, Opioid, mu; Somatostatin; Sucrose | 2006 |
Involvement of mu- and delta-opioid receptors in the antinociceptive effects induced by AMPA receptor antagonist in the spinal cord of rats.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Interactions; Male; Naltrexone; Pain Measurement; Physical Stimulation; Quinoxalines; Rats; Rats, Wistar; Reaction Time; Receptors, AMPA; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord; Wakefulness | 2006 |
Role of kappa- and delta-opioid receptors in the antinociceptive effect of oxytocin in formalin-induced pain response in mice.
Topics: Analgesics; Animals; Behavior; Calcium Channel Blockers; Dose-Response Relationship, Drug; Formaldehyde; Mice; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Nimodipine; Oxytocin; Pain; Random Allocation; Receptors, Opioid, delta; Receptors, Opioid, kappa | 2006 |
Potent in vivo antinociception and opioid receptor preference of the novel analogue [Dmt1]endomorphin-1.
Topics: Analgesia; Animals; Brain; Guinea Pigs; Ileum; Injections, Intraventricular; Male; Mice; Naloxone; Naltrexone; Oligopeptides; Pain; Pain Measurement; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord; Tail; Vas Deferens | 2006 |
The effects of endomorphins and diprotin A on striatal dopamine release induced by electrical stimulation-an in vitro superfusion study in rats.
Topics: Animals; Corpus Striatum; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Dopamine; Electric Stimulation; Infusion Pumps; Male; Naloxone; Naltrexone; Narcotic Antagonists; Neural Pathways; Oligopeptides; Organ Culture Techniques; Presynaptic Terminals; Radioligand Assay; Rats; Rats, Wistar; Substantia Nigra; Synaptic Transmission | 2006 |
Chronic prevention of mu-opioid receptor (MOR) G-protein coupling in the pontine parabrachial nucleus persistently decreases consumption of standard but not palatable food.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Behavior, Animal; Circadian Rhythm; Eating; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Feeding Behavior; Food Preferences; GTP-Binding Proteins; Male; Naltrexone; Narcotic Antagonists; Pons; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Opioid, mu; Time Factors | 2006 |
Involvement of mu-opioid receptors in antinociception and inhibition of gastrointestinal transit induced by 7-hydroxymitragynine, isolated from Thai herbal medicine Mitragyna speciosa.
Topics: Analgesics; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Gastrointestinal Transit; Guinea Pigs; Herbal Medicine; Ileum; Male; Mice; Mitragyna; Molecular Structure; Morphine; Muscle Contraction; Naltrexone; Narcotic Antagonists; Narcotics; Pain; Pain Measurement; Receptors, Opioid, mu; Secologanin Tryptamine Alkaloids; Thailand; Vas Deferens | 2006 |
Involvement of opioid receptors in oxytocin-induced antinociception in the nucleus accumbens of rats.
Topics: Analgesics; Animals; Hot Temperature; Male; Microinjections; Naloxone; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Oxytocin; Pain Measurement; Physical Stimulation; Rats; Rats, Wistar; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2007 |
The role of delta opioid receptors in the anxiolytic actions of benzodiazepines.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Diazepam; Enkephalins; Male; Maze Learning; Naltrexone; Rats; Rats, Long-Evans; Receptors, GABA-A; Receptors, Opioid, delta | 2006 |
Involvement of mu1-opioid receptor on oxycodone-induced antinociception in diabetic mice.
Topics: Analgesics, Opioid; Animals; Diabetes Mellitus, Experimental; Male; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Oxycodone; Receptors, Opioid, mu; Streptozocin | 2007 |
Antagonism of phosphoramidon-induced antinociception in mice by mu- but not kappa-opioid receptor blockers.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Glycopeptides; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2007 |
The opioid antagonist, beta-funaltrexamine, inhibits chemokine expression in human astroglial cells.
Topics: Analysis of Variance; Astrocytes; Astrocytoma; Cell Line, Tumor; Cell Survival; Chemokine CXCL10; Chemokines; Chemokines, CXC; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Activation; Enzyme-Linked Immunosorbent Assay; Fentanyl; Humans; Morphine; Naltrexone; Narcotic Antagonists; Narcotics | 2007 |
AM 251 and beta-Funaltrexamine reduce fat intake in a fat-preferring strain of mouse.
Topics: Analysis of Variance; Animals; Choice Behavior; Dietary Fats; Eating; Energy Intake; Food Preferences; Male; Mice; Mice, Inbred C57BL; Naltrexone; Narcotic Antagonists; Phenotype; Piperidines; Pyrazoles | 2007 |
Sexually dimorphic recruitment of spinal opioid analgesic pathways by the spinal application of morphine.
Topics: Animals; Animals, Newborn; Antibodies; Dose-Response Relationship, Drug; Dynorphins; Female; Injections, Spinal; Male; Morphine; Naltrexone; Narcotic Antagonists; Neural Pathways; Orchiectomy; Ovariectomy; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sex Factors; Spinal Cord; Sufentanil; Virilism | 2007 |
Micro-opioid receptor alkylation in the ventral pallidum and ventral tegmental area, but not in the nucleus accumbens, attenuates the effects of heroin on cocaine self-administration in rats.
Topics: Alkylating Agents; Alkylation; Analysis of Variance; Animals; Behavior, Animal; Cocaine; Conditioning, Operant; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Synergism; Globus Pallidus; Heroin; Male; Naltrexone; Narcotics; Nucleus Accumbens; Rats; Rats, Inbred F344; Receptors, Opioid, mu; Self Administration; Ventral Tegmental Area | 2008 |
Effects of loperamide on mechanical allodynia induced by herpes simplex virus type-1 in mice.
Topics: Analgesics, Opioid; Animals; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Drug Tolerance; Female; Foot; Herpes Simplex; Herpesvirus 1, Human; Injections; Injections, Subcutaneous; Loperamide; Mice; Mice, Inbred C57BL; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Physical Stimulation | 2007 |
The neural pathway of galanin in the hypothalamic arcuate nucleus of rats: activation of beta-endorphinergic neurons projecting to periaqueductal gray matter.
Topics: Animals; Arcuate Nucleus of Hypothalamus; beta-Endorphin; Fluorescent Antibody Technique; Galanin; Hindlimb; Hot Temperature; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Neural Pathways; Neurons; Pain; Periaqueductal Gray; Physical Stimulation; Rats; Rats, Wistar | 2007 |
Increase in diazepam binding inhibitor expression by sustained morphine exposure is mediated via mu-opioid receptors in primary cultures of mouse cerebral cortical neurons.
Topics: Analysis of Variance; Animals; Cells, Cultured; Cerebral Cortex; Diazepam Binding Inhibitor; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; Enzyme Inhibitors; Gene Expression Regulation; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Neurons; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors | 2007 |
Morphine inhibits intrahepatic interferon- alpha expression and enhances complete hepatitis C virus replication.
Topics: Cells, Cultured; Dose-Response Relationship, Drug; Down-Regulation; Gene Expression Regulation; Hepacivirus; Hepatocytes; Humans; Interferon Regulatory Factors; Interferon-alpha; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Virus Replication | 2007 |
Tolerance to repeated morphine administration is associated with increased potency of opioid agonists.
Topics: Analgesics, Opioid; Animals; Brain Chemistry; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Tolerance; Enkephalin, Methionine; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Male; Morphine Dependence; Naltrexone; Narcotic Antagonists; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, mu | 2008 |
Blockade of micro-opioid receptors in the medial thalamus inhibits acquisition, but not expression, of morphine-induced conditioned place preference.
Topics: Animals; Behavior, Animal; Conditioning, Operant; Drug Administration Routes; Drug Interactions; Male; Microinjections; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Thalamus | 2008 |
Methionine-enkephalin modulation of hydrogen peroxide (H2O2) release by rat peritoneal macrophages involves different types of opioid receptors.
Topics: Animals; Benzylidene Compounds; Carcinogens; Dose-Response Relationship, Drug; Enkephalin, Methionine; Hydrogen Peroxide; Macrophages, Peritoneal; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tetradecanoylphorbol Acetate | 2008 |
In vivo characterization of the effects of human hemokinin-1 and human hemokinin-1(4-11), mammalian tachykinin peptides, on the modulation of pain in mice.
Topics: Analgesics; Animals; Benzamides; Bicuculline; Dose-Response Relationship, Drug; GABA Antagonists; Humans; Injections, Intraventricular; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Neurokinin-1 Receptor Antagonists; Pain; Pain Measurement; Peptide Fragments; Piperidines; Receptors, Neurokinin-2; Tachykinins; Tropanes | 2008 |
Beta-funaltrexamine inhibits inducible nitric-oxide synthase expression in human astroglial cells.
Topics: Astrocytes; Cell Line, Tumor; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Humans; Naltrexone; Nitric Oxide Synthase Type II | 2008 |
Mu-opioid receptor in the nucleus submedius: involvement in opioid-induced inhibition of mirror-image allodynia in a rat model of neuropathic pain.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Enkephalin, Leucine-2-Alanine; Hyperalgesia; Ligation; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Neuralgia; Oligopeptides; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Spinal Nerves; Thalamic Nuclei | 2008 |
In vivo characterization of (-)(-)MCL-144 and (+)(-)MCL-193: isomeric, bivalent ligands with mu/kappa agonist properties.
Topics: Alkanes; Analgesics; Animals; Brain; CHO Cells; Cricetinae; Cricetulus; Fumarates; Guanosine 5'-O-(3-Thiotriphosphate); Half-Life; Male; Morphinans; Morphine; Naltrexone; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stereoisomerism | 2008 |
Possible involvement of dynorphin A release via mu1-opioid receptor on supraspinal antinociception of endomorphin-2.
Topics: Analgesics; Animals; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Immune Sera; Injections, Intraventricular; Male; Mice; Naloxone; Naltrexone; Oligopeptides; Protein Precursors; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2008 |
Differential responses to morphine-induced analgesia in the tail-flick test.
Topics: Analgesia; Analgesics, Opioid; Analysis of Variance; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Gene Expression Regulation; Male; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Pain Measurement; Periaqueductal Gray; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Time Factors | 2008 |
Central administration of galanin stimulates feeding behavior in chicks.
Topics: Adrenergic alpha-Antagonists; Animals; Brain; Chickens; Dose-Response Relationship, Drug; Drinking Behavior; Eating; Feeding Behavior; Female; Galanin; Injections, Intraventricular; Male; Naltrexone; Receptors, Opioid, mu; Yohimbine | 2008 |
Food deprivation increases the mRNA expression of micro-opioid receptors in the ventral medial hypothalamus and arcuate nucleus.
Topics: Animals; Arcuate Nucleus of Hypothalamus; Dietary Fats; Eating; Food Deprivation; Hyperalgesia; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Long-Evans; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Ventromedial Hypothalamic Nucleus | 2008 |
The effects of endomorphins on striatal [3H]GABA release induced by electrical stimulation: an in vitro superfusion study in rats.
Topics: Animals; Corpus Striatum; Dipeptidyl-Peptidase IV Inhibitors; Electric Stimulation; gamma-Aminobutyric Acid; Male; Naloxone; Naltrexone; Oligopeptides; Perfusion; Rats; Rats, Wistar; Receptors, Opioid, mu; Tritium | 2009 |
Central administration of metastin increases food intake through opioid neurons in chicks.
Topics: Animals; Chickens; Eating; Humans; Injections, Intraventricular; Kisspeptins; Naltrexone; Neurons; Neuropeptides; Receptors, Opioid, mu; Tumor Suppressor Proteins | 2009 |
Motor stimulant effects of ethanol and acetaldehyde injected into the posterior ventral tegmental area of rats: role of opioid receptors.
Topics: Acetaldehyde; Animals; Central Nervous System Depressants; Dose-Response Relationship, Drug; Ethanol; Injections, Intraventricular; Male; Microinjections; Motor Activity; Naltrexone; Rats; Rats, Wistar; Receptors, Opioid, mu; Ventral Tegmental Area | 2009 |
Involvement of exon 11-associated variants of the mu opioid receptor MOR-1 in heroin, but not morphine, actions.
Topics: Alternative Splicing; Analgesia; Animals; Exons; Gastrointestinal Transit; Gene Targeting; Heroin; Heterozygote; Mice; Mice, Knockout; Morphine; Mutation; Naloxone; Naltrexone; Receptors, Opioid, mu | 2009 |
Receptor reserve reflects differential intrinsic efficacy associated with opioid diastereomers.
Topics: Analgesics, Opioid; Animals; CHO Cells; Cricetinae; Cricetulus; Humans; Mice; Naltrexone; Receptors, Opioid, mu; Sodium Chloride; Stereoisomerism | 2009 |
Central administration of somatostatin stimulates feeding behavior in chicks.
Topics: Alkylating Agents; Animals; Animals, Newborn; Chickens; Eating; Enkephalin, Leucine; Hormones; Male; Naltrexone; Narcotic Antagonists; Neuropeptides; Receptors, Opioid; Somatostatin | 2009 |
Association of increased pain threshold by noise with central opioid neurons.
Topics: Analgesia; Animals; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Noise; Opioid Peptides; Pain Measurement; Pain Threshold; Receptors, Opioid, delta; Receptors, Opioid, mu; Stress, Physiological | 2009 |
Synthesis and biological evaluation of cyclic endomorphin-2 analogs.
Topics: Amino Acid Sequence; Analgesics, Opioid; Animals; Brain; Cell Membrane; Endorphins; Injections, Intravenous; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain; Pain Measurement; Peptides, Cyclic; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Tissue Extracts | 2010 |
Mu and kappa opioid receptor expression in the mediobasal hypothalamus and effectiveness of selective antagonists on prolactin release during lactation.
Topics: Analysis of Variance; Animals; Animals, Suckling; Chromatography, High Pressure Liquid; Dopamine; Female; Hypothalamus; Injections, Intraventricular; Lactation; Naltrexone; Neurons; Prolactin; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sucking Behavior | 2010 |
Antinociceptive effects of galanin in the central nucleus of amygdala of rats, an involvement of opioid receptors.
Topics: Amygdala; Animals; Galanin; Hindlimb; Hot Temperature; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Physical Stimulation; Rats; Rats, Wistar; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Time Factors | 2010 |
Chronic suppression of μ-opioid receptor signaling in the nucleus accumbens attenuates development of diet-induced obesity in rats.
Topics: Animals; Body Weight; Dietary Fats; Dietary Sucrose; Food Preferences; Food, Formulated; Male; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Obesity; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 2010 |
Locomotor stimulant effects of acute and repeated intrategmental injections of salsolinol in rats: role of mu-opioid receptors.
Topics: Animals; Dose-Response Relationship, Drug; Injections, Intraventricular; Isoquinolines; Male; Microinjections; Motor Activity; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid, mu; Ventral Tegmental Area | 2010 |
The involvement of micro-opioid receptors in the central nervous system in the worsening of allergic airway inflammation by psychological stress in mice.
Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Central Nervous System; Cytokines; Disease Models, Animal; Female; Humans; Immunoglobulin E; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphine; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu; Stress, Psychological; Th2 Cells | 2010 |
Reversible suppression of food reward behavior by chronic mu-opioid receptor antagonism in the nucleus accumbens.
Topics: Animals; Appetitive Behavior; Male; Microinjections; Motivation; Naltrexone; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Reinforcement, Psychology; Reward; Sucrose | 2010 |
Peripheral antinociceptive effects of the cyclic endomorphin-1 analog c[YpwFG] in a mouse visceral pain model.
Topics: Analgesics; Animals; Injections, Intraperitoneal; Injections, Intraventricular; Injections, Subcutaneous; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain; Peptides, Cyclic; Receptors, Opioid, mu | 2010 |
Activation of phosphatidylinositol 3-kinase/Akt-mammalian target of Rapamycin signaling pathway in the hippocampus is essential for the acquisition of morphine-induced place preference in rats.
Topics: Animals; Chromones; Conditioning, Operant; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glial Fibrillary Acidic Protein; Hippocampus; Male; Morphine; Morpholines; Naltrexone; Narcotic Antagonists; Narcotics; Phosphatidylinositol 3-Kinases; Phosphopyruvate Hydratase; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction; Sirolimus; Statistics as Topic | 2010 |
The antidepressant-like effect of human opiorphin via opioid-dependent pathways in mice.
Topics: Animals; Antidepressive Agents; Dose-Response Relationship, Drug; Habituation, Psychophysiologic; Humans; Injections, Intraventricular; Male; Mice; Motor Activity; Naloxone; Naltrexone; Oligopeptides; Receptors, Opioid, delta; Receptors, Opioid, mu; Salivary Proteins and Peptides; Signal Transduction | 2011 |
Involvement of the lateral amygdala in the antiallodynic and reinforcing effects of heroin in rats after peripheral nerve injury.
Topics: Amygdala; Analgesics, Opioid; Animals; Behavior, Animal; Brain; Conditioning, Operant; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Guanosine 5'-O-(3-Thiotriphosphate); Heroin; Hyperalgesia; Infusions, Intravenous; Male; Naltrexone; Narcotic Antagonists; Peripheral Nerve Injuries; Rats; Rats, Inbred F344; Reinforcement, Psychology; Self Administration; Spinal Nerves | 2011 |
Understanding the effect of different assay formats on agonist parameters: a study using the µ-opioid receptor.
Topics: Arrestin; Cell Line; Cyclic AMP; Drug Discovery; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Kinetics; Naltrexone; Narcotic Antagonists; Protein Binding; Receptors, Opioid, mu | 2011 |
Induction of conditioned place preference and dopamine release by salsolinol in posterior VTA of rats: involvement of μ-opioid receptors.
Topics: Animals; Conditioning, Operant; Dopamine; Isoquinolines; Limbic System; Male; Microdialysis; Microinjections; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Rats; Rats, Wistar; Receptors, Opioid, mu; Ventral Tegmental Area | 2011 |
Involvement of the opioid system in the orexigenic and hedonic effects of melanin-concentrating hormone.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Eating; Hypothalamic Hormones; Injections, Intraventricular; Male; Melanins; Models, Animal; Naltrexone; Narcotic Antagonists; Pituitary Hormones; Rats; Rats, Wistar; Receptors, Opioid; Sucrose; Taste | 2011 |
Central administration of neuronostatin induces antinociception in mice.
Topics: Acute Pain; Analgesics; Animals; Dose-Response Relationship, Drug; Immunohistochemistry; Infusions, Intraventricular; Male; Melanocyte-Stimulating Hormones; Mice; Models, Animal; Naloxone; Naltrexone; Narcotic Antagonists; Nociception; Peptide Hormones; Periaqueductal Gray; Proto-Oncogene Proteins c-fos; Receptor, Melanocortin, Type 3; Receptor, Melanocortin, Type 4 | 2011 |
Endogenous opioid and cannabinoid mechanisms are involved in the analgesic effects of celecoxib in the central nervous system.
Topics: Analgesics; Animals; Carrageenan; Celecoxib; Central Nervous System; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Inflammation; Male; Naltrexone; Pain; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Opioid, delta; Receptors, Opioid, mu; Sulfonamides | 2012 |
The rewarding action of acute cocaine is reduced in β-endorphin deficient but not in μ opioid receptor knockout mice.
Topics: Animals; Behavior, Animal; beta-Endorphin; Cocaine; Conditioning, Operant; Male; Mice; Mice, Knockout; Morphine; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu; Reward | 2012 |
Supraspinal antinociceptive effect of apelin-13 in a mouse visceral pain model.
Topics: Acetic Acid; Analgesics; Analgesics, Opioid; Animals; Drug Synergism; Injections, Intraperitoneal; Injections, Intraventricular; Injections, Spinal; Intercellular Signaling Peptides and Proteins; Male; Mice; Morphine; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Nociception; Visceral Pain | 2012 |
Differential development of antinociceptive tolerance to morphine and fentanyl is not linked to efficacy in the ventrolateral periaqueductal gray of the rat.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Fentanyl; Male; Microinjections; Morphine; Naltrexone; Narcotic Antagonists; Pain Measurement; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Reaction Time | 2012 |
Role of µ-opioid receptor reserve and µ-agonist efficacy as determinants of the effects of µ-agonists on intracranial self-stimulation in rats.
Topics: Animals; Brain; Drug Tolerance; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Reinforcement Schedule; Self Stimulation | 2012 |
The mu-opioid receptor-selective peptide antagonists, antanal-1 and antanal-2, produce anticonvulsant effects in mice.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electroshock; Hand Strength; Male; Mice; Muscle Strength; Naltrexone; Oligopeptides; Pentylenetetrazole; Receptors, Opioid, mu; Seizures | 2013 |
Anxiolytic effects of ethanol are partially related to a reduced expression of adenylyl cyclase 5 but not to μ-opioid receptor activation in rat nucleus accumbens.
Topics: Adenylyl Cyclases; Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Disease Models, Animal; Ethanol; Exploratory Behavior; Gene Expression Regulation, Enzymologic; Male; Maze Learning; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Rats; Rats, Wistar; Receptors, Opioid, mu; RNA, Messenger; Time Factors | 2012 |
Involvement of peripheral cannabinoid and opioid receptors in β-caryophyllene-induced antinociception.
Topics: Animals; Cannabinoids; Endorphins; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Nociception; Pain; Pain Measurement; Polycyclic Sesquiterpenes; Receptor, Cannabinoid, CB2; Sesquiterpenes | 2013 |
Antinociceptive effects of two deltorphins analogs in the tail-immersion test in rats.
Topics: Analgesics, Opioid; Animals; Drug Synergism; Drug Tolerance; Male; Morphine; Naltrexone; Narcotic Antagonists; Nociception; Oligopeptides; Pain Measurement; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa | 2013 |
Β-funaltrexamine inhibits chemokine (CXCL10) expression in normal human astrocytes.
Topics: Astrocytes; Base Sequence; Cells, Cultured; Chemokine CXCL10; DNA Primers; Enzyme Activation; Gene Products, tat; Humans; Interferon-gamma; Naltrexone; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Real-Time Polymerase Chain Reaction | 2013 |
μ-opioid receptors in the stimulation of mesolimbic dopamine activity by ethanol and morphine in Long-Evans rats: a delayed effect of ethanol.
Topics: Animals; Dopamine; Dose-Response Relationship, Drug; Ethanol; Injections, Intravenous; Injections, Subcutaneous; Male; Microdialysis; Microinjections; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Long-Evans; Receptors, Opioid, mu; Time Factors; Ventral Tegmental Area | 2013 |
Effect of naloxone on ischemic acute kidney injury in the mouse.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Hypothalamus, Anterior; Injections, Intraperitoneal; Injections, Intraventricular; Kidney; Male; Mice; Mice, Inbred ICR; Molecular Targeted Therapy; Naloxone; Naltrexone; Narcotic Antagonists; Nerve Tissue Proteins; Neurons; Proto-Oncogene Proteins c-fos; Receptors, Opioid, mu; Renal Insufficiency; Reperfusion Injury | 2013 |
Effects of co-administration of intrathecal nociceptin/orphanin FQ and opioid antagonists on formalin-induced pain in rats.
Topics: Analgesics; Animals; Formaldehyde; Injections, Spinal; Male; Naltrexone; Narcotic Antagonists; Nociceptin; Opioid Peptides; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid | 2013 |
The selective μ opioid receptor antagonist β-funaltrexamine attenuates methamphetamine-induced stereotypical biting in mice.
Topics: Animals; Behavior, Animal; Central Nervous System Stimulants; Male; Methamphetamine; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu; Stereotyped Behavior | 2013 |
Orexigenic effects of endomorphin-2 (EM-2) related to decreased CRH gene expression and increased dopamine and norepinephrine activity in the hypothalamus.
Topics: Agouti-Related Protein; Animals; Arcuate Nucleus of Hypothalamus; Corticotropin-Releasing Hormone; Dopamine; Feeding Behavior; Gene Expression Regulation; Humans; Hypothalamus; Intracellular Signaling Peptides and Proteins; Naltrexone; Nerve Tissue Proteins; Neuropeptide Y; Neuropeptides; Norepinephrine; Oligopeptides; Orexins; Pro-Opiomelanocortin; Rats; Serotonin | 2013 |
Involvement of delta and mu opioid receptors in the acute and sensitized locomotor action of cocaine in mice.
Topics: Animals; Cocaine; Humans; Mice; Motor Activity; Naltrexone; Oligopeptides; Pain Measurement; Receptors, Opioid, delta; Receptors, Opioid, mu | 2013 |
Involvement of spinal cord opioid mechanisms in the acute antinociceptive effect of hyperbaric oxygen in mice.
Topics: Acetic Acid; Analgesia; Animals; beta-Endorphin; Dynorphins; Enkephalin, Methionine; Hyperbaric Oxygenation; Injections, Spinal; Male; Mice; Naltrexone; Narcotic Antagonists; Spinal Cord | 2013 |
Involvement of spinal release of α-neo-endorphin on the antinociceptive effect of TAPA.
Topics: Analgesia; Analgesics, Opioid; Animals; Endorphins; Gene Expression; Immune Sera; Injections, Spinal; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Naloxone; Naltrexone; Narcotic Antagonists; Nociception; Oligopeptides; Protein Precursors; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord; Tail | 2013 |
Synthesis of [15, 16- ³H] beta-funaltrexamine.
Topics: Isotope Labeling; Naltrexone; Radiopharmaceuticals; Tritium | 2013 |
Antinociceptive activity of a synthetic oxopyrrolidine-based compound, ASH21374, and determination of its possible mechanisms.
Topics: Analgesics; Analgesics, Opioid; Animals; Aspirin; Capsaicin; Cyclic GMP; Glutamic Acid; Male; Mice; Mice, Inbred BALB C; Morphine; Motor Activity; Naloxone; Naltrexone; Nitric Oxide; Pyrrolidines; Rats, Sprague-Dawley; Receptors, Opioid | 2013 |
Mu opioid receptor antagonism in the nucleus accumbens shell blocks consumption of a preferred sucrose solution in an anticipatory contrast paradigm.
Topics: Animals; Anticipation, Psychological; Food Preferences; Learning; Male; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Random Allocation; Rats; Rats, Long-Evans; Receptors, Opioid, delta; Receptors, Opioid, mu; Sucrose | 2014 |
Novel orally available salvinorin A analog PR-38 inhibits gastrointestinal motility and reduces abdominal pain in mouse models mimicking irritable bowel syndrome.
Topics: Abdominal Pain; Administration, Oral; Animals; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Diarrhea; Disease Models, Animal; Diterpenes, Clerodane; Dose-Response Relationship, Drug; Exploratory Behavior; Gastrointestinal Motility; Injections, Intraperitoneal; Irritable Bowel Syndrome; Male; Mice; Motor Activity; Naltrexone; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2014 |
Opposite effects of neuropeptide FF on central antinociception induced by endomorphin-1 and endomorphin-2 in mice.
Topics: Adamantane; Animals; Benzeneacetamides; Dipeptides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Injections, Intraventricular; Male; Mice; Naltrexone; Nociception; Oligopeptides; Pyrrolidines | 2014 |
Downregulation of spinal endomorphin-2 correlates with mechanical allodynia in a rat model of tibia cancer.
Topics: Analgesics; Animals; Bone Neoplasms; Disease Models, Animal; Down-Regulation; Female; Hyperalgesia; Morphine; Naltrexone; Narcotic Antagonists; Oligopeptides; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Tibia | 2015 |
K303⁶·⁵⁸ in the μ opioid (MOP) receptor is important in conferring selectivity for covalent binding of β-funaltrexamine (β-FNA).
Topics: Animals; Cell Line, Tumor; Conserved Sequence; Extracellular Space; Humans; Lysine; Mice; Molecular Docking Simulation; Mutation; Naltrexone; Narcotic Antagonists; Protein Binding; Protein Conformation; Rats; Receptors, Opioid, kappa; Receptors, Opioid, mu; Substrate Specificity | 2015 |
Enkephalin analog, cyclo[N(ε),N(β)-carbonyl-D-Lys(2),Dap(5)] enkephalinamide (cUENK6), inhibits the ethanol withdrawal-induced anxiety-like behavior in rats.
Topics: Analgesics, Opioid; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Central Nervous System Depressants; Enkephalin, Leucine; Enkephalins; Ethanol; Morphine; Naltrexone; Narcotic Antagonists; Neurotransmitter Agents; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Substance Withdrawal Syndrome | 2015 |
Mechanism Underlying the Analgesic Effect Exerted by Endomorphin-1 in the rat Ventrolateral Periaqueductal Gray.
Topics: Analgesics; Animals; Axons; GABAergic Neurons; Male; Microinjections; Naltrexone; Neural Inhibition; Oligopeptides; Peptides; Periaqueductal Gray; Rats, Sprague-Dawley; Receptors, GABA; Receptors, Opioid, mu; Serotonin; Synapses; Synaptic Transmission | 2016 |
Behavioral and neurochemical analysis of ongoing bone cancer pain in rats.
Topics: Adenocarcinoma; Analgesics, Opioid; Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Bone Neoplasms; Cell Line, Tumor; Diclofenac; Disease Models, Animal; Female; Gyrus Cinguli; Lidocaine; Morphine; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Pain; Rats; Rats, Inbred F344 | 2015 |
The opioid antagonist, β-funaltrexamine, inhibits NF-κB signaling and chemokine expression in human astrocytes and in mice.
Topics: Animals; Astrocytes; Behavior, Animal; Brain; Chemokine CXCL10; Gene Expression Regulation; Humans; Interleukin-1beta; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Naltrexone; Narcotic Antagonists; NF-kappa B; Signal Transduction | 2015 |
Role of thalamic nuclei in the modulation of Fos expression within the cerebral cortex during hypertonic saline-induced muscle nociception.
Topics: Animals; Cerebral Cortex; Disease Models, Animal; Electric Stimulation; Functional Laterality; Male; Myalgia; Naltrexone; Narcotic Antagonists; Neural Pathways; Nociceptive Pain; Proto-Oncogene Proteins c-fos; Rats, Sprague-Dawley; Receptors, Opioid, mu; Saline Solution, Hypertonic; Thalamic Nuclei; Time Factors | 2015 |
Differences in the morphine-induced inhibition of small and large intestinal transit: Involvement of central and peripheral μ-opioid receptors in mice.
Topics: Analgesics, Opioid; Animals; Central Nervous System; Dose-Response Relationship, Drug; Gastrointestinal Transit; Injections, Intraventricular; Intestine, Large; Intestine, Small; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Peripheral Nervous System; Receptors, Opioid, mu | 2016 |
Inhibitory Effect of Endomorphin-2 Binding to the μ-Opioid Receptor in the Rat Pre-Bötzinger Complex on the Breathing Activity.
Topics: Animals; Brain Stem; Male; Naltrexone; Narcotic Antagonists; Oligopeptides; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Respiratory Mechanics | 2017 |
μ Opioid receptor: novel antagonists and structural modeling.
Topics: Crystallography, X-Ray; Humans; Molecular Docking Simulation; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu | 2016 |
Mechanisms of pentazocine-induced ventilatory depression and antinociception in anesthetized rats.
Topics: Analgesics; Anesthesia; Animals; Male; Naltrexone; Pentazocine; Rats, Wistar; Receptors, Opioid, kappa; Receptors, Opioid, mu; Respiratory Insufficiency | 2016 |
The anxiolytic- and antidepressant-like effects of ATPM-ET, a novel κ agonist and μ partial agonist, in mice.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Avoidance Learning; Emotions; Exploratory Behavior; Hindlimb Suspension; Locomotion; Mice; Morphinans; Naltrexone; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2016 |
The opioid antagonist, β-funaltrexamine, inhibits lipopolysaccharide-induced neuroinflammation and reduces sickness behavior in mice.
Topics: Animals; Brain; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Encephalitis; Exploratory Behavior; Illness Behavior; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Naltrexone; Narcotic Antagonists; Statistics as Topic | 2017 |
Methyl-orvinol-Dual activity opioid receptor ligand inhibits gastrointestinal transit and alleviates abdominal pain in the mouse models mimicking diarrhea-predominant irritable bowel syndrome.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Abdominal Pain; Analgesics; Analgesics, Opioid; Animals; Colon; Diarrhea; Disease Models, Animal; Gastrointestinal Motility; Gastrointestinal Transit; Irritable Bowel Syndrome; Male; Mice; Mice, Inbred BALB C; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Receptors, Opioid; Thebaine | 2017 |
Characterization of functional μ opioid receptor turnover in rat locus coeruleus: an electrophysiological and immunocytochemical study.
Topics: Analgesics, Opioid; Animals; Electrophysiological Phenomena; Enkephalin, Methionine; Locus Coeruleus; Male; Naltrexone; Narcotic Antagonists; Neurons; Rats, Sprague-Dawley; Receptors, Opioid, mu | 2017 |
Understanding the molecular basis of agonist/antagonist mechanism of human mu opioid receptor through gaussian accelerated molecular dynamics method.
Topics: Amino Acid Motifs; Catalytic Domain; Humans; Models, Molecular; Molecular Dynamics Simulation; Morphinans; Naltrexone; Normal Distribution; Protein Binding; Protein Conformation; Pyrroles; Receptors, Opioid, mu | 2017 |
Possible involvement of the μ opioid receptor in the antinociception induced by sinomenine on formalin-induced nociceptive behavior in mice.
Topics: Administration, Oral; Analgesics; Animals; Dose-Response Relationship, Drug; Formaldehyde; Male; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morphinans; Naloxone; Naltrexone; Nociception; Receptors, Opioid, mu; Spinal Cord | 2019 |
β-Funaltrexamine Displayed Anti-inflammatory and Neuroprotective Effects in Cells and Rat Model of Stroke.
Topics: Animals; Anti-Inflammatory Agents; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Arginase; Brain; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; Dinoprostone; Interferon-gamma; Interleukin-1beta; Lipopolysaccharides; Male; Naltrexone; Neuroglia; Neurons; Neuroprotective Agents; NF-kappa B; Nitric Oxide; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Stroke; Tumor Necrosis Factor-alpha | 2020 |
Single-molecule analysis reveals agonist-specific dimer formation of µ-opioid receptors.
Topics: Animals; beta-Arrestins; CHO Cells; Cricetulus; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Fluorescence Resonance Energy Transfer; Morphine; Mutation; Naloxone; Naltrexone; Narcotic Antagonists; Phosphorylation; Protein Multimerization; Receptors, Opioid, mu; Single Molecule Imaging | 2020 |
Exploring the putative mechanism of allosteric modulations by mixed-action kappa/mu opioid receptor bitopic modulators.
Topics: Allosteric Regulation; Allosteric Site; Binding Sites; Humans; Ligands; Molecular Docking Simulation; Morphinans; Naltrexone; Protein Binding; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spiro Compounds; Thermodynamics | 2021 |
Antidepressant-like effects of dezocine in mice: involvement of 5-HT1A and κ opioid receptors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Antidepressive Agents; Behavior, Animal; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Drug Monitoring; Drug Therapy, Combination; Mice; Naltrexone; Piperazines; Pyridines; Receptors, Opioid, kappa; Receptors, Opioid, mu; Serotonin 5-HT1 Receptor Antagonists; Tetrahydronaphthalenes; Treatment Outcome | 2021 |