naltrexone and 7-benzylidenenaltrexone

naltrexone has been researched along with 7-benzylidenenaltrexone in 96 studies

Research

Studies (96)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	47 (48.96)	18.2507
2000's	35 (36.46)	29.6817
2010's	12 (12.50)	24.3611
2020's	2 (2.08)	2.80

Authors

Authors	Studies
Nelson, WL; Palmer, RB; Upthagrove, AL	1
Fujii, H; Kobayashi, S; Miyata, Y; Nagase, H; Osa, Y; Takeuchi, T	1
Iwata, S; Koyama, Y; Kutsumura, N; Miyata, Y; Nagase, H; Nagumo, Y; Nakajima, R; Saitoh, T; Yamamoto, N; Yoshida, N	1
Nagase, H; Portoghese, PS; Sultana, M; Takemori, AE	1
Collins, KA; Portoghese, PS; Tsai, JH; Tseng, LF	1
Hammond, DL; Littell, L; Stewart, PE	1
Armstead, WM	1
Funada, M; Iwamoto, Y; Kamei, J; Kasuya, Y; Misawa, M; Nagase, H; Saitoh, A; Suzuki, T	1
Funada, M; Misawa, M; Mori, T; Nagase, H; Suzuki, T	1
Kamei, J; Misawa, M; Mizoguchi, H; Nagase, H; Suzuki, T; Yoshiike, M	1
Misawa, M; Mori, T; Nagase, H; Suzuki, T; Tsuji, M	2
Iwamoto, Y; Kamei, J; Kasuya, Y; Misawa, M; Nagase, H	1
Fujimoto, JM; Portoghese, PS; Rady, JJ; Takemori, AE	1
D'Alecy, LG; Mayfield, KP	2
Moe, ST; Portoghese, PS; Sultana, M; Takemori, AE	1
Iwamoto, Y; Kamei, J; Kasuya, Y; Misawa, M; Nagase, H; Suzuki, T	1
Ludbrook, J; Ventura, S	1
Hitosugi, H; Iwamoto, Y; Kamei, J; Kasuya, Y; Misawa, M; Nagase, H	1
Portoghese, PS; Takemori, AE	2
Búzás, B; Cox, BM; Izenwasser, S; Portoghese, PS	1
Bowen, WD; Carlisi, VJ; Hruby, VJ; Mosberg, HI; Porreca, F; Portoghese, PS; Sultana, M; Takemori, AE; Wild, KD	1
Portoghese, PS; Sofuoglu, M; Takemori, AE	1
Collins, KA; Portoghese, PS; Tseng, LF	1
Kinter, CM; Lever, JR; Scheffel, U; Stathis, M	1
Mizoguchi, H; Nagase, H; Narita, M; Quock, RM; Suzuki, T; Tseng, LF	1
Endoh, T; Misawa, M; Mori, T; Nagase, H; Suzuki, T; Tsuji, M	1
Mokha, SS; Wang, XM; Yan, JQ; Zhang, KM	1
Fujimoto, J; Ho, BY; Holmes, BB; Zhao, J	1
Baemmert, D; Fujimoto, JM; Portoghese, PS; Rady, JJ; Takemori, AE	1
Khan, S; Smith, ME	1
Hitosugi, H; Kamei, J; Kashiwazaki, T; Nagase, H	1
Dawson-Basoa, M; Gintzler, AR	2
Donahue, BB; Hammond, DL; Stewart, PE	1
Hammond, DL; Thorat, SN	1
Szekeres, PG; Traynor, JR	1
Gross, GJ; Hsu, AK; Schultz, JE	1
Ananthan, S; Riley, ME; Weber, RJ	1
Ohkawa, S; Portoghese, PS	1
Fujimoto, JM; Gorny, JM; Rady, JJ	1
Eells, JT; Fryer, RM; Gross, GJ; Hsu, AK; Nagase, H	1
Hitosugi, H; Kamei, J; Kashiwazaki, T; Nagase, H; Taki, K	1
Gross, GJ; Liang, BT	1
Kamei, J; Nagase, H; Ohsawa, M; Onodera, K; Taki, K	1
Gross, GJ; Huh, J; Liang, BT; Nagase, H	1
Fryer, RM; Gross, GJ; Hsu, AK; Wang, Y	1
Mika, J; Przewłocka, B; Przewłocki, R	1
Fujimoto, JM; Holmes, BB; Rady, JJ; Tseng, LF	1
Brown, DR; Poonyachoti, S; Portoghese, PS	1
Bilsky, EJ; Raehal, KM; Sadée, W; Wang, D	1
Kukreja, RC	1
Gross, GJ; Hsu, A; Moore, J; Patel, HH	1
McPherson, BC; Yao, Z	1
Filliol, D; Gavériaux-Ruff, C; Kieffer, BL; Matthes, HW; Simonin, F	1
Badhwar, V; Bolling, SF; Kilgore, K; Oeltgen, PR; Schwartz, CF; Su, TP	1
Fujimura, T; Hayashi, T; Kastin, AJ; Murayama, K; Narita, M; Orito, T; Sakurada, C; Sakurada, S; Sakurada, T; Suzuki, T; Tan-no, K; Tseng, LF; Yuhki, M; Zadina, JE	1
Bolli, R; Kodani, E; Shinmura, K; Takano, H; Tang, XL; Xuan, YT	1
Broom, DC; Nitsche, JF; Pintar, JE; Rice, KC; Traynor, JR; Woods, JH	1
Caffrey, JL; Farias, M; Jackson, KE; Yoshishige, D	1
Fujita, S; Nakae, Y; Namiki, A	1
Gross, GJ; Peart, JN	1
Lunzer, MM; Portoghese, PS	2
Brown, DR; Townsend, DW	1
Sárváry, L; Schulze, F; Strasser, RH; Weinbrenner, C	1
Cools, AR; Hirose, N; Koshikawa, N; Murakawa, K; Nagase, H; Suzuki, T; Takada, K	1
Agadjanov, MI; Agadjanova, EM; Batikyan, TB; Tadevosyan, YV; Vartanian, GS	1
Bhamidipati, CM; Bilsky, EJ; Blair, JR; Lowery, JJ; Paolino, RM; Raehal, KM; Sadée, W; Wang, D	1
Kamei, J; Onodera, K; Saitoh, A; Yoshikawa, Y	1
Cools, AR; Hirose, N; Koshikawa, N; Murakawa, K; Nagase, H; Oi, Y; Suzuki, T; Takada, K	1
Castro, MS; Duarte, ID; Francischi, JN; Pacheco, DF; Perez, AC; Reis, GM	1
Chang, KJ; Gengo, PJ; Gross, GJ; Holt, JD; O'Neill, SJ; Pendergast, W; Watson, MJ; Wei, K	1
Kamei, J; Miyata, S; Saitoh, A; Takahashi, M	1
Barlow, MA; Caffrey, JL; Deo, SH; Johnson-Davis, S; Yoshishige, D	1
Barlow, M; Caffrey, JL; Davis, S; Deo, SH; Farias, M; Yoshishige, D	1
Sadee, W; Sun, X; Wang, D	1
Dimitrijević, M; Kovacević-Jovanović, V; Kustrimović, N; Miletić, T; Mitić, K; Stanojević, S; Vujić, V	1
Arout, CA; Inturrisi, CE; Juni, A; Kest, B; Klein, G; Waxman, AR	1
Chefer, VI; Shippenberg, TS; Thompson, AC	1
Barzakh, EI; Chernysheva, GA; Cybulnikov, SY; Krieg, T; Krylatov, AV; Lishmanov, AY; Maslov, LN; Solenkova, NV; Zhang, Y	1
Fujii, H; Kobayashi, S; Miyata, Y; Nagase, H; Takeuchi, T; Uenohara, Y	1
Harvey, JH; van Rijn, RM; Whistler, JL	1
Nagase, H; Oka, J; Saitoh, A; Sugiyama, A; Yamada, M	1
Jiang, S; Liu, Z; Song, L; Wang, L; Wang, W; Zhang, R; Zhou, Z	1
Beaudry, H; Gendron, L; Morón, JA	1
Fujii, H; Iwata, S; Koyama, Y; Kutsumura, N; Miyata, Y; Nagase, H; Nakajima, R; Saitoh, T; Yamamoto, N	1
Chung, HK; Lamb, K; Lin, MZ; Plemper, RK; Weisshaar, M; Yan, D	1
Asahi, H; Inoue, SI; Kobayashi, F; Kunigo, K; Niikura, M; Sendo, F; Suzuki, Y	1
Chuang, EY; Hsiao, YW; Huang, DY; Hwai, H; Jhou, JP; Lai, LC; Tseng, TC; Tzeng, SJ	1
Hokari, R; Ishiyama, A; Iwatsuki, M; Koyama, Y; Kutsumura, N; Miyata, Y; Nagase, H; Nagumo, Y; Ōmura, S; Otoguro, K; Saitoh, T; Yamamoto, N	1
Maslov, LN; Naryzhnaya, NV; Nesterov, EA; Prokudina, ES; Tsibulnikov, SY	1
Bell, GI; Chen, Y; Kong, H; Raynor, K; Reisine, T; Yasuda, K; Yu, L	1
Adapa, ID; Auh, JS; Berzetei-Gurske, IP; Brandt, SR; Craymer, K; Farrington, L; Haggart, D; Kennedy, JM; O'Brien, A; Polgar, WE; Rodriguez, L; Schwartz, RW; Toll, L; White, A	1

Other Studies

96 other study(ies) available for naltrexone and 7-benzylidenenaltrexone

Article	Year
(E)- and (Z)-7-arylidenenaltrexones: synthesis and opioid receptor radioligand displacement assays. Journal of medicinal chemistry, 1997, Feb-28, Volume: 40, Issue:5 Topics: Animals; Benzeneacetamides; Benzomorphans; Benzylidene Compounds; Binding, Competitive; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Magnetic Resonance Spectroscopy; Mass Spectrometry; Models, Molecular; Molecular Conformation; Molecular Structure; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid, delta; Spectroscopy, Fourier Transform Infrared	1997
Opioid δ₁ receptor antagonist 7-benzylidenenaltrexone as an effective resistance reverser for chloroquine-resistant Plasmodium chabaudi. Bioorganic & medicinal chemistry letters, 2011, Aug-15, Volume: 21, Issue:16 Topics: Antimalarials; Benzylidene Compounds; Chloroquine; Drug Resistance; Molecular Structure; Naltrexone; Parasitic Sensitivity Tests; Plasmodium chabaudi; Receptors, Opioid, mu; Stereoisomerism; Structure-Activity Relationship	2011
Antitrichomonal activity of δ opioid receptor antagonists, 7-benzylidenenaltrexone derivatives. Bioorganic & medicinal chemistry, 2017, 08-15, Volume: 25, Issue:16 Topics: Animals; Antitrichomonal Agents; Benzylidene Compounds; CHO Cells; Cricetulus; Dose-Response Relationship, Drug; Molecular Structure; Naltrexone; Receptors, Opioid, delta; Structure-Activity Relationship; Trichomonas vaginalis	2017
A highly selective delta 1-opioid receptor antagonist: 7-benzylidenenaltrexone. European journal of pharmacology, 1992, Jul-21, Volume: 218, Issue:1 Topics: Animals; Benzylidene Compounds; Guinea Pigs; In Vitro Techniques; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta	1992
Spinal delta 2-, but not delta 1-, mu-, or kappa-opioid receptors are involved in the tail-flick inhibition induced by beta-endorphin from nucleus raphe obscurus in the pentobarbital-anesthetized rat. European journal of pharmacology, 1995, Apr-24, Volume: 277, Issue:2-3 Topics: Amino Acid Sequence; Analgesia; Animals; Benzylidene Compounds; beta-Endorphin; Dose-Response Relationship, Drug; Enkephalin, Methionine; Injections, Intraventricular; Injections, Spinal; Male; Molecular Sequence Data; Naltrexone; Narcotic Antagonists; Pentobarbital; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin; Spinal Cord; Tail	1995
Antinociception and delta-1 opioid receptors in the rat spinal cord: studies with intrathecal 7-benzylidenenaltrexone. The Journal of pharmacology and experimental therapeutics, 1995, Volume: 274, Issue:3 Topics: Analgesics; Animals; Benzylidene Compounds; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Spinal; Male; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Spinal Cord	1995
The contribution of delta 1- and delta 2-opioid receptors to hypoxia-induced pial artery dilation in the newborn pig. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1995, Volume: 15, Issue:3 Topics: Animals; Animals, Newborn; Benzylidene Compounds; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Hypoxia; Male; Naltrexone; Narcotic Antagonists; Oligopeptides; Pia Mater; Receptors, Opioid, delta; Receptors, Opioid, mu; Swine; Vasodilation	1995
Effects of diabetes on spontaneous locomotor activity in mice. Neuroscience letters, 1994, Aug-29, Volume: 178, Issue:1 Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Benzazepines; Benzylidene Compounds; Brain; Corpus Striatum; Diabetes Mellitus, Experimental; Dopamine; Haloperidol; Homovanillic Acid; Male; Mice; Mice, Inbred ICR; Motor Activity; Naltrexone; Narcotic Antagonists; Prosencephalon; Receptors, Dopamine D1; Receptors, Opioid, delta; Reference Values	1994
Attenuation of the discriminative stimulus properties of cocaine by delta-opioid receptor antagonists. European journal of pharmacology, 1994, Sep-22, Volume: 263, Issue:1-2 Topics: Animals; Benzylidene Compounds; Cocaine; Discrimination Learning; Dose-Response Relationship, Drug; Male; Naltrexone; Rats; Rats, Inbred F344; Receptors, Opioid, delta	1994
Blockade of delta-opioid receptors prevents morphine-induced place preference in mice. Japanese journal of pharmacology, 1994, Volume: 66, Issue:1 Topics: Analgesics; Animals; Benzylidene Compounds; Conditioning, Operant; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Mice, Inbred Strains; Morphine; Naltrexone; Narcotic Antagonists; Oligopeptides; Receptors, Opioid, delta; Receptors, Opioid, mu	1994
The role of delta-opioid receptor subtypes in cocaine- and methamphetamine-induced place preferences. Life sciences, 1994, Volume: 55, Issue:17 Topics: Animals; Benzylidene Compounds; Cocaine; Conditioning, Psychological; Male; Methamphetamine; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Reinforcement, Psychology	1994
Streptozotocin-induced diabetes selectively enhances antinociception mediated by delta 1- but not delta 2-opioid receptors. Life sciences, 1994, Volume: 55, Issue:6 Topics: Analgesia; Animals; Benzylidene Compounds; Diabetes Mellitus, Experimental; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Mice, Inbred ICR; Naltrexone; Oligopeptides; Receptors, Opioid, delta; Receptors, Opioid, mu; Streptozocin	1994
Supraspinal delta receptor subtype activity of heroin and 6-monoacetylmorphine in Swiss Webster mice. Life sciences, 1994, Volume: 55, Issue:8 Topics: Animals; Benzylidene Compounds; Heroin; Male; Mice; Morphine Derivatives; Naltrexone; Pain; Receptors, Opioid, delta	1994
Delta-1 opioid agonist acutely increases hypoxic tolerance. The Journal of pharmacology and experimental therapeutics, 1994, Volume: 268, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adaptation, Physiological; Animals; Benzylidene Compounds; Body Temperature; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hypoxia; Male; Mice; Naltrexone; Pyrrolidines; Receptors, Opioid, delta	1994
Synthesis of naltrexone-derived delta-opioid antagonists. Role of conformation of the delta address moiety. Journal of medicinal chemistry, 1994, Mar-04, Volume: 37, Issue:5 Topics: Animals; Benzylidene Compounds; Electric Stimulation; Guinea Pigs; Ileum; Male; Mice; Models, Molecular; Molecular Conformation; Molecular Structure; Muscle, Smooth; Naltrexone; Receptors, Opioid, delta; Structure-Activity Relationship; Vas Deferens	1994
Involvement of delta 1-opioid receptor antagonism in the antitussive effect of delta-opioid receptor antagonists. European journal of pharmacology, 1994, Jan-14, Volume: 251, Issue:2-3 Topics: Animals; Antitussive Agents; Benzylidene Compounds; Capsaicin; Cough; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta	1994
The decompensatory phase of acute hypovolaemia in rabbits involves a central delta 1-opioid receptor. European journal of pharmacology, 1994, Jan-24, Volume: 252, Issue:1 Topics: Animals; Benzylidene Compounds; Blood Pressure; Cardiac Output; Enkephalin, Leucine; Hemodynamics; Hemorrhage; Naltrexone; Narcotic Antagonists; Rabbits; Receptors, Opioid, delta; Shock	1994
Differential mediation of cold water swim stress-induced antinociception by delta-opioid receptor subtypes in diabetic mice. Life sciences, 1994, Volume: 54, Issue:23 Topics: Analgesia; Animals; Benzylidene Compounds; Cold Temperature; Diabetes Mellitus, Experimental; Male; Mice; Mice, Inbred ICR; Naltrexone; Receptors, Opioid, delta; Streptozocin; Stress, Physiological; Swimming	1994
Enkephalin antinociception in mice is mediated by delta 1- and delta 2-opioid receptors in the brain and spinal cord, respectively. European journal of pharmacology, 1993, Sep-28, Volume: 242, Issue:2 Topics: Animals; Benzylidene Compounds; beta-Endorphin; Brain; Enkephalin, Leucine; Enkephalin, Methionine; Injections, Intraventricular; Injections, Spinal; Male; Mice; Naltrexone; Pain; Receptors, Opioid, delta; Spinal Cord	1993
Delta-1 opioid receptor dependence of acute hypoxic adaptation. The Journal of pharmacology and experimental therapeutics, 1994, Volume: 268, Issue:1 Topics: Adaptation, Physiological; Animals; Benzylidene Compounds; Hypoxia; Male; Mice; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta	1994
Evidence for delta opioid receptor subtypes regulating adenylyl cyclase activity in rat brain. Life sciences, 1994, Volume: 54, Issue:7 Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Analgesics; Animals; Benzylidene Compounds; Caudate Nucleus; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Male; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta	1994
Evidence for a single functional opioid delta receptor subtype in the mouse isolated vas deferens. The Journal of pharmacology and experimental therapeutics, 1993, Volume: 264, Issue:2 Topics: Animals; Benzylidene Compounds; Drug Tolerance; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; In Vitro Techniques; Isothiocyanates; Male; Mice; Mice, Inbred ICR; Morphinans; Naltrexone; Oligopeptides; Receptors, Opioid, delta; Thiocyanates; Vas Deferens	1993
7-Benzylidenenaltrexone (BNTX): a selective delta 1 opioid receptor antagonist in the mouse spinal cord. Life sciences, 1993, Volume: 52, Issue:8 Topics: Analgesics; Animals; Benzylidene Compounds; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Naltrexone; Narcotic Antagonists; Oligopeptides; Receptors, Opioid, delta; Spinal Cord	1993
Spinal delta 2 but not delta 1 opioid receptors are involved in intracerebroventricular beta-endorphin-induced antinociception in the mouse. Life sciences, 1993, Volume: 52, Issue:19 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzylidene Compounds; beta-Endorphin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Nociceptors; Pain Measurement; Pyrrolidines; Receptors, Opioid, delta; Spinal Cord	1993
The mixed antinociceptive agonist-antagonist activity of beta-endorphin(1-27) in mice. Life sciences, 1993, Volume: 53, Issue:13 Topics: Animals; Benzylidene Compounds; beta-Endorphin; Male; Mice; Naltrexone; Narcotic Antagonists; Nociceptors; Peptide Fragments; Receptors, Opioid	1993
In vivo labeling of delta opioid receptors in mouse brain by [3H]benzylidenenaltrexone, a ligand selective for the delta 1 subtype. Life sciences, 1996, Volume: 58, Issue:21 Topics: Animals; Benzylidene Compounds; Corpus Striatum; Male; Mice; Naltrexone; Radioligand Assay; Receptors, Opioid, delta; Tritium	1996
Use of antisense oligodeoxynucleotide to determine delta-opioid receptor involvement in [D-Ala2]deltorphin II-induced locomotor hyperactivity. Life sciences, 1996, Volume: 59, Issue:4 Topics: Amino Acid Sequence; Analysis of Variance; Animals; Base Sequence; Benzylidene Compounds; Cerebral Ventricles; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Molecular Sequence Data; Motor Activity; Naltrexone; Narcotic Antagonists; Oligonucleotides, Antisense; Oligopeptides; Receptors, Opioid, delta; Somatostatin; Thionucleotides	1996
Effect of the highly selective and nonpeptide delta opioid receptor agonist TAN-67 on the morphine-induced place preference in mice. The Journal of pharmacology and experimental therapeutics, 1996, Volume: 279, Issue:1 Topics: Analgesics; Animals; Benzylidene Compounds; Dopamine; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Limbic System; Male; Mice; Morphine; Naltrexone; Quinolines; Receptors, Opioid, delta; Reward	1996
Role of opioid receptors (mu, delta 1, delta 2) in modulating responses of nociceptive neurons in the superficial and deeper dorsal horn of the medulla (trigeminal nucleus caudalis) in the rat. Brain research, 1996, Nov-11, Volume: 739, Issue:1-2 Topics: Animals; Benzylidene Compounds; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Evoked Potentials; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nerve Fibers; Neurons; Nociceptors; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Trigeminal Caudal Nucleus	1996
Determination of delta-opioid in NG108-15 cells. European journal of pharmacology, 1997, Jan-14, Volume: 319, Issue:1 Topics: Animals; Benzylidene Compounds; Cyclic AMP; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Glioma; Mice; Naltrexone; Neuroblastoma; Rats; Receptors, Opioid, delta; Tumor Cells, Cultured	1997
Spinal delta opioid receptor subtype activity of 6-monoacetylmorphine in Swiss Webster mice. Pharmacology, biochemistry, and behavior, 1997, Volume: 56, Issue:2 Topics: Analgesics, Opioid; Animals; Benzylidene Compounds; beta-Endorphin; Dose-Response Relationship, Drug; Injections, Intraventricular; Injections, Spinal; Male; Mice; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Pain Measurement; Receptors, Opioid, delta; Spinal Cord	1997
Actions of beta-endorphin peptides on the contractions of mouse diaphragm muscle. Peptides, 1997, Volume: 18, Issue:1 Topics: Animals; Benzylidene Compounds; beta-Endorphin; Diaphragm; Dipeptides; Electric Stimulation; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Mice; Mice, Inbred C57BL; Muscle Contraction; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Neostigmine; Oligopeptides; Peptide Fragments	1997
The role of spinal delta1-opioid receptors in inhibiting the formalin-induced nociceptive response in diabetic mice. European journal of pharmacology, 1997, May-12, Volume: 326, Issue:1 Topics: Analgesics; Animals; Benzylidene Compounds; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Formaldehyde; Injections, Intraventricular; Injections, Spinal; Injections, Subcutaneous; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Pain Measurement; Receptors, Opioid, delta; Spinal Cord	1997
Involvement of spinal cord delta opiate receptors in the antinociception of gestation and its hormonal simulation. Brain research, 1997, May-16, Volume: 757, Issue:1 Topics: Animals; Benzylidene Compounds; Female; Humans; Injections, Spinal; Male; Naltrexone; Narcotic Antagonists; Pain; Pregnancy; Pregnancy, Animal; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Sensory Thresholds; Sex Characteristics; Spinal Cord; Time Factors	1997
The role of delta-opioid receptors in the discriminative stimulus properties of a low dose of methamphetamine. European journal of pharmacology, 1997, Jul-16, Volume: 331, Issue:1 Topics: Animals; Benzylidene Compounds; Central Nervous System Stimulants; Discrimination, Psychological; Dose-Response Relationship, Drug; Male; Methamphetamine; Naltrexone; Quinolines; Rats; Rats, Inbred F344; Receptors, Opioid, delta	1997
Role of spinal delta1 and delta2 opioid receptors in the antinociception produced by microinjection of L-glutamate in the ventromedial medulla of the rat. Brain research, 1997, Aug-08, Volume: 765, Issue:1 Topics: Analgesics; Animals; Benzylidene Compounds; Glutamic Acid; Isothiocyanates; Male; Medulla Oblongata; Microinjections; Naltrexone; Narcotic Antagonists; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Spinal Cord	1997
Modulation of nociception by microinjection of delta-1 and delta-2 opioid receptor ligands in the ventromedial medulla of the rat. The Journal of pharmacology and experimental therapeutics, 1997, Volume: 283, Issue:3 Topics: Analgesics, Opioid; Animals; Benzylidene Compounds; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Medulla Oblongata; Microinjections; Naltrexone; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta	1997
Delta opioid modulation of the binding of guanosine-5'-O-(3-[35S]thio)triphosphate to NG108-15 cell membranes: characterization of agonist and inverse agonist effects. The Journal of pharmacology and experimental therapeutics, 1997, Volume: 283, Issue:3 Topics: Animals; Benzylidene Compounds; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Mice; Naltrexone; Neuroblastoma; Rats; Receptors, Opioid, delta; Sodium	1997
Ischemic preconditioning in the intact rat heart is mediated by delta1- but not mu- or kappa-opioid receptors. Circulation, 1998, Apr-07, Volume: 97, Issue:13 Topics: Animals; Benzylidene Compounds; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hemodynamics; Ischemic Preconditioning, Myocardial; Male; Myocardial Infarction; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu	1998
Gestational and ovarian sex steroid antinociception: synergy between spinal kappa and delta opioid systems. Brain research, 1998, May-25, Volume: 794, Issue:1 Topics: Animals; Benzylidene Compounds; Dose-Response Relationship, Drug; Estrogens; Female; Naltrexone; Narcotic Antagonists; Ovary; Pain Threshold; Pregnancy; Pregnancy, Animal; Progesterone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Spinal Cord	1998
Novel non-peptidic opioid compounds with immunopotentiating effects. Advances in experimental medicine and biology, 1998, Volume: 437 Topics: Adjuvants, Immunologic; Animals; Benzylidene Compounds; Cell Division; Male; Naltrexone; Narcotics; Rats; Rats, Inbred F344; Somatostatin; Structure-Activity Relationship; T-Lymphocytes	1998
7-Arylidenenaltrexones as selective delta1 opioid receptor antagonists. Journal of medicinal chemistry, 1998, Oct-08, Volume: 41, Issue:21 Topics: Animals; Benzylidene Compounds; Electric Stimulation; Guinea Pigs; Ileum; In Vitro Techniques; Ligands; Male; Mice; Mice, Inbred ICR; Muscle Contraction; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Pain Measurement; Receptors, Opioid, delta; Structure-Activity Relationship; Tail; Vas Deferens	1998
Heroin antinociception changed from mu to delta receptor in streptozotocin-treated mice. Japanese journal of pharmacology, 1998, Volume: 78, Issue:4 Topics: Analgesics, Opioid; Animals; Anti-Bacterial Agents; Benzylidene Compounds; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Heroin; Injections, Intraventricular; Male; Mice; Morphine; Morphine Derivatives; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Pain; Receptors, Opioid, delta; Receptors, Opioid, mu; Streptozocin; Time Factors	1998
Opioid-induced second window of cardioprotection: potential role of mitochondrial KATP channels. Circulation research, 1999, Apr-16, Volume: 84, Issue:7 Topics: Analgesics; Animals; Benzylidene Compounds; Blood Pressure; Coronary Circulation; Glyburide; Hypoglycemic Agents; Ischemic Preconditioning, Myocardial; Male; Mitochondria; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Naltrexone; Narcotic Antagonists; Potassium Channels; Quinolines; Rats; Rats, Wistar; Receptors, Opioid, delta	1999
Algogenic mediator-induced nociceptive response in diabetic mice. European journal of pharmacology, 1999, Mar-26, Volume: 369, Issue:3 Topics: Animals; Benzylidene Compounds; Bradykinin; Diabetes Mellitus, Experimental; Dinoprost; Dose-Response Relationship, Drug; Formaldehyde; Injections, Subcutaneous; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Pain; Receptors, Opioid, delta; Somatostatin	1999
Direct preconditioning of cardiac myocytes via opioid receptors and KATP channels. Circulation research, 1999, Jun-25, Volume: 84, Issue:12 Topics: Adenosine Triphosphate; Analgesics, Opioid; Animals; Anti-Arrhythmia Agents; Benzylidene Compounds; Cells, Cultured; Chick Embryo; Decanoic Acids; Hydroxy Acids; Ischemic Preconditioning, Myocardial; Morphine; Muscle Fibers, Skeletal; Myocardium; Naloxone; Naltrexone; Narcotic Antagonists; Potassium Channels; Receptors, Opioid	1999
Involvement of spinal delta 1-opioid receptors in forced walking stress-induced antinociception in the tail-flick test in mice. Methods and findings in experimental and clinical pharmacology, 1999, Volume: 21, Issue:9 Topics: Analgesics; Animals; Benzylidene Compounds; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Pain Measurement; Receptors, Opioid, delta; Stress, Physiological; Time Factors; Walking	1999
Protection of cardiac myocytes via delta(1)-opioid receptors, protein kinase C, and mitochondrial K(ATP) channels. American journal of physiology. Heart and circulatory physiology, 2001, Volume: 280, Issue:1 Topics: Adenosine Triphosphate; Alkaloids; Animals; Benzophenanthridines; Benzylidene Compounds; Cells, Cultured; Chick Embryo; Enzyme Inhibitors; Glyburide; Heart; Ischemia; Ischemic Preconditioning, Myocardial; Mitochondria, Heart; Myocardium; Naltrexone; Narcotic Antagonists; Phenanthridines; Potassium Channel Blockers; Protein Kinase C; Quinolines	2001
Essential activation of PKC-delta in opioid-initiated cardioprotection. American journal of physiology. Heart and circulatory physiology, 2001, Volume: 280, Issue:3 Topics: Acetophenones; Alkaloids; Analgesics; Animals; Benzophenanthridines; Benzopyrans; Benzylidene Compounds; Enkephalin, Leucine-2-Alanine; Enzyme Activation; Enzyme Inhibitors; Heart Rate; Indoles; Ischemic Preconditioning, Myocardial; Isoenzymes; Male; Maleimides; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Naltrexone; Narcotic Antagonists; Phenanthridines; Protein Kinase C; Protein Kinase C-delta; Quinolines; Rats; Rats, Wistar; Receptors, Opioid, delta	2001
The role of delta-opioid receptor subtypes in neuropathic pain. European journal of pharmacology, 2001, Mar-09, Volume: 415, Issue:1 Topics: Analgesics, Opioid; Animals; Behavior, Animal; Benzylidene Compounds; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Isothiocyanates; Male; Naltrexone; Narcotic Antagonists; Neuralgia; Oligopeptides; Pain Measurement; Protein Isoforms; Rats; Rats, Wistar; Receptors, Opioid, delta; Sciatic Nerve; Time Factors	2001
Inverse agonist action of Leu-enkephalin at delta(2)-opioid receptors mediates spinal antianalgesia. The Journal of pharmacology and experimental therapeutics, 2001, Volume: 297, Issue:2 Topics: Analgesics, Opioid; Animals; Benzylidene Compounds; Cholecystokinin; Drug Tolerance; Enkephalin, Leucine; Excitatory Amino Acid Agonists; Male; Mice; Morphine; N-Methylaspartate; Naltrexone; Narcotic Antagonists; Pain Measurement; Receptors, Opioid, delta; Spinal Cord	2001
Pharmacological evidence for a 7-benzylidenenaltrexone-preferring opioid receptor mediating the inhibitory actions of peptidic delta- and mu-opioid agonists on neurogenic ion transport in porcine ileal mucosa. The Journal of pharmacology and experimental therapeutics, 2001, Volume: 297, Issue:2 Topics: Animals; Benzylidene Compounds; Electric Stimulation; Epithelium; Evoked Potentials; Female; Immunohistochemistry; In Vitro Techniques; Intestinal Mucosa; Male; Microscopy, Confocal; Naltrexone; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Swine	2001
Inverse agonists and neutral antagonists at mu opioid receptor (MOR): possible role of basal receptor signaling in narcotic dependence. Journal of neurochemistry, 2001, Volume: 77, Issue:6 Topics: Analgesics, Opioid; Animals; Benzylidene Compounds; Cell Line; Cell Membrane; Cyclic AMP; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Kidney; Magnesium; Male; Mice; Mice, Inbred ICR; Morphine; Morphine Dependence; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Receptors, Opioid, mu; Signal Transduction; Substance Withdrawal Syndrome; Sulfur Radioisotopes; Transfection; Tritium	2001
Essential role of oxygen radicals in delayed pharmacological preconditioning. Journal of molecular and cellular cardiology, 2001, Volume: 33, Issue:8 Topics: Animals; Antioxidants; Benzamides; Benzylidene Compounds; Dose-Response Relationship, Drug; Drug Therapy, Combination; Free Radicals; Humans; Ischemic Preconditioning, Myocardial; Myocardial Ischemia; Naltrexone; Narcotic Antagonists; Oxygen; Piperazines; Quinolines; Rats; Receptors, Opioid, delta; Tiopronin	2001
BW373U86, a delta opioid agonist, partially mediates delayed cardioprotection via a free radical mechanism that is independent of opioid receptor stimulation. Journal of molecular and cellular cardiology, 2001, Volume: 33, Issue:8 Topics: Animals; Antioxidants; Benzamides; Benzylidene Compounds; Dose-Response Relationship, Drug; Free Radicals; Ischemic Preconditioning, Myocardial; Male; Myocardial Ischemia; Myocardial Reperfusion; Naltrexone; Narcotic Antagonists; Piperazines; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Tiopronin	2001
Signal transduction of opioid-induced cardioprotection in ischemia-reperfusion. Anesthesiology, 2001, Volume: 94, Issue:6 Topics: Animals; ATP-Binding Cassette Transporters; Benzamides; Benzylidene Compounds; Cell Survival; Chick Embryo; Decanoic Acids; Free Radicals; Hydroxy Acids; KATP Channels; Myocardial Reperfusion Injury; Myocardium; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Oxidative Stress; Piperazines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Opioid, delta; Signal Transduction	2001
Immunosuppression by delta-opioid antagonist naltrindole: delta- and triple mu/delta/kappa-opioid receptor knockout mice reveal a nonopioid activity. The Journal of pharmacology and experimental therapeutics, 2001, Volume: 298, Issue:3 Topics: Animals; Benzylidene Compounds; Cell Division; Concanavalin A; Dipeptides; Immunosuppressive Agents; Interleukin-2; Lymphocyte Culture Test, Mixed; Lymphocytes; Mice; Mice, Knockout; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, sigma; T-Lymphocytes; Tetrahydroisoquinolines	2001
Opioids confer myocardial tolerance to ischemia: interaction of delta opioid agonists and antagonists. The Journal of thoracic and cardiovascular surgery, 2001, Volume: 122, Issue:3 Topics: Analgesics, Opioid; Animals; Benzylidene Compounds; Cardiac Surgical Procedures; Coronary Circulation; Disease Models, Animal; Drug Evaluation, Preclinical; Enkephalin, D-Penicillamine (2,5)-; Heart Arrest, Induced; Hypothermia, Induced; Ischemic Preconditioning, Myocardial; Myocardial Ischemia; Naltrexone; Narcotic Antagonists; Organ Size; Oxygen Consumption; Rabbits; Receptors, Opioid, delta; Recovery of Function; Stroke Volume; Ventricular Pressure	2001
Differential antinociceptive effects induced by intrathecally administered endomorphin-1 and endomorphin-2 in the mouse. European journal of pharmacology, 2001, Sep-21, Volume: 427, Issue:3 Topics: Analgesics; Animals; Benzylidene Compounds; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Methionine; Immune Sera; Injections, Spinal; Injections, Subcutaneous; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain; Pain Measurement; Pain Threshold; Peptide Fragments; Time Factors	2001
Delta-opioid receptor-induced late preconditioning is mediated by cyclooxygenase-2 in conscious rabbits. American journal of physiology. Heart and circulatory physiology, 2002, Volume: 283, Issue:5 Topics: 6-Ketoprostaglandin F1 alpha; Animals; Benzamides; Benzylidene Compounds; Celecoxib; Consciousness; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Heart Rate; Ischemic Preconditioning, Myocardial; Isoenzymes; Male; Myocardial Infarction; Myocardial Stunning; Myocardium; Naltrexone; Narcotic Antagonists; Nitrobenzenes; Piperazines; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rabbits; Receptors, Opioid, delta; Sulfonamides	2002
Comparison of receptor mechanisms and efficacy requirements for delta-agonist-induced convulsive activity and antinociception in mice. The Journal of pharmacology and experimental therapeutics, 2002, Volume: 303, Issue:2 Topics: Analgesics; Analgesics, Opioid; Animals; Benzamides; Benzylidene Compounds; Convulsants; Drug Tolerance; Enkephalin, D-Penicillamine (2,5)-; Male; Mice; Mice, Knockout; Naltrexone; Narcotic Antagonists; Piperazines; Receptors, Opioid, delta	2002
Cardiac enkephalins interrupt vagal bradycardia via delta 2-opioid receptors in sinoatrial node. American journal of physiology. Heart and circulatory physiology, 2003, Volume: 284, Issue:5 Topics: Analgesics; Analgesics, Opioid; Animals; Benzylidene Compounds; Bradycardia; Dogs; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Naltrexone; Narcotic Antagonists; Oligopeptides; Opioid Peptides; Quinolines; Receptors, Opioid, delta; Sinoatrial Node; Vagus Nerve	2003
Modulation of myofilament Ca2+ densitivity by delta- and kappa-opioid agonists in intact guinea pig hearts. Anesthesia and analgesia, 2003, Volume: 96, Issue:3 Topics: Actin Cytoskeleton; Animals; Benzylidene Compounds; Blood Pressure; Calcium; Coronary Circulation; Guinea Pigs; Heart; Heart Rate; In Vitro Techniques; Kinetics; Naltrexone; Narcotic Antagonists; Pyrrolidines; Quinolines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Stimulation, Chemical; Ventricular Function, Left	2003
Adenosine and opioid receptor-mediated cardioprotection in the rat: evidence for cross-talk between receptors. American journal of physiology. Heart and circulatory physiology, 2003, Volume: 285, Issue:1 Topics: Adenosine; Analgesics, Opioid; Animals; ATP-Binding Cassette Transporters; Benzylidene Compounds; Free Radicals; Heart Diseases; In Vitro Techniques; KATP Channels; Mitochondria, Heart; Morphine; Myocardial Infarction; Myocardial Reperfusion Injury; Naltrexone; Potassium Channels; Potassium Channels, Inwardly Rectifying; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptor Cross-Talk; Receptors, Opioid, delta; Receptors, Purinergic P1	2003
Identity of the putative delta1-opioid receptor as a delta-kappa heteromer in the mouse spinal cord. European journal of pharmacology, 2003, Apr-25, Volume: 467, Issue:1-3 Topics: Animals; Benzylidene Compounds; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Immune Sera; Mice; Naltrexone; Oligopeptides; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin; Spinal Cord	2003
Pharmacological characterization of a 7-benzylidenenaltrexone-preferring opioid receptor in porcine ileal submucosa. British journal of pharmacology, 2003, Volume: 140, Issue:4 Topics: Amphibian Proteins; Animals; Anions; Benzamides; Benzylidene Compounds; Biological Transport, Active; Carrier Proteins; Diprenorphine; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Female; Gastrointestinal Motility; Ileum; Intestinal Mucosa; Male; Naltrexone; Neurons, Afferent; Oligopeptides; Piperazines; Quinolines; Receptors, Opioid, delta; Receptors, Opioid, mu; Swine; Tritium	2003
Remote preconditioning by infrarenal aortic occlusion is operative via delta1-opioid receptors and free radicals in vivo in the rat heart. Cardiovascular research, 2004, Feb-15, Volume: 61, Issue:3 Topics: Animals; Aorta, Abdominal; Aorta, Thoracic; Benzylidene Compounds; Free Radical Scavengers; Free Radicals; Glycine; Ischemic Preconditioning, Myocardial; Ligation; Male; Myocardial Infarction; Myocardium; Naltrexone; Rats; Rats, Wistar; Receptors, Opioid, delta; Signal Transduction; Sulfhydryl Compounds	2004
Deltorphin II enhances extracellular levels of dopamine in the nucleus accumbens via opioid receptor-independent mechanisms. European journal of pharmacology, 2004, Apr-26, Volume: 491, Issue:1 Topics: Analysis of Variance; Anesthetics, Local; Animals; Benzylidene Compounds; Dopamine; Extracellular Space; Male; Microdialysis; Naloxone; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Somatostatin; Tetrodotoxin; Time Factors	2004
Possible role of the phosphoinositide pathway for signal transduction in changes in the sensitivity of delta-opiate receptors during diabetes mellitus. Bulletin of experimental biology and medicine, 2004, Volume: 137, Issue:2 Topics: Benzylidene Compounds; Diabetes Mellitus; Diglycerides; Humans; In Vitro Techniques; Lymphocytes; Naltrexone; Oligopeptides; Phosphatidylinositols; Receptors, Opioid, delta; Signal Transduction	2004
In vivo characterization of 6beta-naltrexol, an opioid ligand with less inverse agonist activity compared with naltrexone and naloxone in opioid-dependent mice. The Journal of pharmacology and experimental therapeutics, 2005, Volume: 313, Issue:3 Topics: Animals; Benzylidene Compounds; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice; Mice, Inbred ICR; Morphine; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders	2005
Role of delta-opioid receptor subtypes in anxiety-related behaviors in the elevated plus-maze in rats. Psychopharmacology, 2005, Volume: 182, Issue:3 Topics: Animals; Anxiety; Benzamides; Benzylidene Compounds; Blood Specimen Collection; Corticosterone; Male; Maze Learning; Naltrexone; Piperazines; Rats; Rats, Inbred Lew; Receptors, Opioid, delta	2005
Interactions among mu- and delta-opioid receptors, especially putative delta1- and delta2-opioid receptors, promote dopamine release in the nucleus accumbens. Neuroscience, 2005, Volume: 135, Issue:1 Topics: Analgesics, Opioid; Anesthetics, Local; Animals; Benzylidene Compounds; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Extracellular Space; Male; Microdialysis; Naloxone; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Somatostatin; Tetrodotoxin	2005
delta-Opioid receptor agonist SNC80 elicits peripheral antinociception via delta(1) and delta(2) receptors and activation of the l-arginine/nitric oxide/cyclic GMP pathway. Life sciences, 2005, Nov-19, Volume: 78, Issue:1 Topics: Analgesics; Animals; Arginine; Benzamides; Benzylidene Compounds; Cyclic GMP; Dinoprostone; Enzyme Inhibitors; Hyperalgesia; Male; Naltrexone; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Piperazines; Rats; Receptors, Opioid, delta	2005
ARD-353 [4-((2R,5S)-4-(R)-(4-diethylcarbamoylphenyl)(3-hydroxyphenyl)methyl)-2,5-dimethylpiperazin-1-ylmethyl)benzoic acid], a novel nonpeptide delta receptor agonist, reduces myocardial infarct size without central effects. The Journal of pharmacology and experimental therapeutics, 2006, Volume: 316, Issue:1 Topics: Animals; Benzoates; Benzylidene Compounds; Binding, Competitive; Cardiotonic Agents; Catalepsy; Dose-Response Relationship, Drug; Hemodynamics; In Vitro Techniques; Male; Mice; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Naltrexone; Piperazines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reflex; Seizures	2006
Involvement of delta1-opioid receptors in the spatial learning impairment in streptozotocin-induced diabetic mice. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 2005, Volume: 25, Issue:5 Topics: Animals; Benzylidene Compounds; Diabetes Mellitus, Experimental; Enkephalins; Escape Reaction; Mice; Naltrexone; Reaction Time; Receptors, Opioid, delta; Space Perception	2005
Repeated delta1-opioid receptor stimulation reduces delta2-opioid receptor responses in the SA node. American journal of physiology. Heart and circulatory physiology, 2006, Volume: 291, Issue:5 Topics: Analgesics; Analgesics, Opioid; Animals; Benzylidene Compounds; Bradycardia; Dogs; Dose-Response Relationship, Drug; Enkephalin, Methionine; Female; Male; Microdialysis; Naltrexone; Narcotic Antagonists; Oligopeptides; Quinolines; Receptors, Opioid, delta; Sinoatrial Node; Stimulation, Chemical; Vagus Nerve	2006
The monosialosyl ganglioside GM-1 reduces the vagolytic efficacy of delta2-opioid receptor stimulation. American journal of physiology. Heart and circulatory physiology, 2006, Volume: 291, Issue:5 Topics: Analgesics, Opioid; Animals; Benzylidene Compounds; Bradycardia; Dogs; Dose-Response Relationship, Drug; Enkephalin, Methionine; Female; G(M1) Ganglioside; Male; Naltrexone; Narcotic Antagonists; Oligopeptides; Receptors, Opioid, delta; Sinoatrial Node; Stimulation, Chemical; Vagus Nerve	2006
Different effects of opioid antagonists on mu-, delta-, and kappa-opioid receptors with and without agonist pretreatment. The Journal of pharmacology and experimental therapeutics, 2007, Volume: 321, Issue:2 Topics: Benzylidene Compounds; Cells, Cultured; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Morphine; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Signal Transduction	2007
Selectivity of delta- and kappa-opioid ligands depends on the route of central administration in mice. The Journal of pharmacology and experimental therapeutics, 2007, Volume: 322, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzylidene Compounds; Enkephalin, D-Penicillamine (2,5)-; Injections, Intraventricular; Injections, Spinal; Ligands; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta; Receptors, Opioid, kappa	2007
Methionine-enkephalin modulation of hydrogen peroxide (H2O2) release by rat peritoneal macrophages involves different types of opioid receptors. Neuropeptides, 2008, Volume: 42, Issue:2 Topics: Animals; Benzylidene Compounds; Carcinogens; Dose-Response Relationship, Drug; Enkephalin, Methionine; Hydrogen Peroxide; Macrophages, Peritoneal; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tetradecanoylphorbol Acetate	2008
Acute and chronic heroin dependence in mice: contribution of opioid and excitatory amino acid receptors. European journal of pharmacology, 2008, May-31, Volume: 586, Issue:1-3 Topics: Acute Disease; Animals; Behavior, Animal; Benzylidene Compounds; Chronic Disease; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Heroin Dependence; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Substance Withdrawal Syndrome; Time Factors	2008
Delta-opioid receptor antagonists prevent sensitization to the conditioned rewarding effects of morphine. Biological psychiatry, 2009, Jan-15, Volume: 65, Issue:2 Topics: Analysis of Variance; Animals; Association Learning; Behavior, Animal; Benzylidene Compounds; Conditioning, Classical; Disease Models, Animal; Male; Morphine Dependence; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptor Cross-Talk; Receptors, Opioid, delta; Receptors, Opioid, mu; Reinforcement, Psychology; Statistics, Nonparametric	2009
Opioid peptide deltorphin II simulates the cardioprotective effect of ischemic preconditioning: role of δ₂-opioid receptors, protein kinase C, and K(ATP) channels. Bulletin of experimental biology and medicine, 2010, Volume: 149, Issue:5 Topics: Animals; Benzophenanthridines; Benzylidene Compounds; Decanoic Acids; Glyburide; Hydroxy Acids; Ischemic Preconditioning, Myocardial; Male; Myocardial Reperfusion Injury; Naltrexone; Oligopeptides; Potassium Channel Blockers; Potassium Channels; Protein Kinase C; Rats; Rats, Wistar; Receptors, Opioid, delta	2010
Investigation of 7-benzylidenenaltrexone derivatives as resistance reverser for chloroquine-resistant Plasmodium chabaudi. Bioorganic & medicinal chemistry letters, 2012, Aug-15, Volume: 22, Issue:16 Topics: Antimalarials; Benzylidene Compounds; Chloroquine; Drug Resistance; Glutathione Reductase; Naltrexone; Plasmodium chabaudi	2012
A FLIPR assay for evaluating agonists and antagonists of GPCR heterodimers. Methods in molecular biology (Clifton, N.J.), 2013, Volume: 995 Topics: Benzylidene Compounds; Calcium Signaling; Cell Culture Techniques; Drug Evaluation, Preclinical; Enkephalin, D-Penicillamine (2,5)-; HEK293 Cells; High-Throughput Screening Assays; Humans; Naltrexone; Receptors, G-Protein-Coupled; Receptors, Opioid, delta; Recombinant Proteins; Spectrometry, Fluorescence; Transfection	2013
DOR(2)-selective but not DOR(1)-selective antagonist abolishes anxiolytic-like effects of the δ opioid receptor agonist KNT-127. Neuropharmacology, 2014, Volume: 79 Topics: Animals; Anti-Anxiety Agents; Anxiety; Benzylidene Compounds; Exploratory Behavior; Formaldehyde; Male; Maze Learning; Morphinans; Naltrexone; Narcotic Antagonists; Neuropsychological Tests; Nociception; Rats; Rats, Wistar; Receptors, Opioid, delta	2014
The immunomodulation mediated by a delta-opioid receptor for [Met(5)]-enkephalin in oyster Crassostrea gigas. Developmental and comparative immunology, 2015, Volume: 49, Issue:2 Topics: Amino Acid Sequence; Animals; Benzylidene Compounds; Calcium; Cell Line; Cloning, Molecular; Crassostrea; Cyclic AMP; DNA, Complementary; Enkephalin, Methionine; HEK293 Cells; Hepatopancreas; Humans; Lipopolysaccharides; Molecular Sequence Data; Naltrexone; Phagocytosis; Receptors, Opioid, delta; RNA, Messenger; Sequence Alignment; Signal Transduction; Vibrio	2015
Implication of delta opioid receptor subtype 2 but not delta opioid receptor subtype 1 in the development of morphine analgesic tolerance in a rat model of chronic inflammatory pain. The European journal of neuroscience, 2015, Volume: 41, Issue:7 Topics: Analgesics, Opioid; Animals; Benzylidene Compounds; Chronic Pain; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Tolerance; Freund's Adjuvant; Hindlimb; Inflammation; Male; Morphine; Naltrexone; Narcotic Antagonists; Rats, Sprague-Dawley; Receptors, Opioid, delta	2015
Investigation of 7-benzylidenenaltrexone derivatives as a novel structural antitrichomonal lead compound. Bioorganic & medicinal chemistry letters, 2015, Nov-01, Volume: 25, Issue:21 Topics: Antitrichomonal Agents; Benzylidene Compounds; Dose-Response Relationship, Drug; Female; Humans; Molecular Structure; Naltrexone; Receptors, Opioid, delta; Structure-Activity Relationship; Trichomonas Vaginitis	2015
Replication-Competent Influenza Virus and Respiratory Syncytial Virus Luciferase Reporter Strains Engineered for Co-Infections Identify Antiviral Compounds in Combination Screens. Biochemistry, 2015, Sep-15, Volume: 54, Issue:36 Topics: Animals; Antiviral Agents; Benzylidene Compounds; Cell Line; Coinfection; Dogs; Dose-Response Relationship, Drug; Feasibility Studies; Fenretinide; Genes, Reporter; High-Throughput Screening Assays; Humans; Influenza A virus; Luciferases, Firefly; Luciferases, Renilla; Naltrexone; Narcotic Antagonists; Neuraminidase; Respiratory Syncytial Viruses; Ribavirin; Virus Internalization; Virus Replication; Zanamivir	2015
Profiling molecular factors associated with pyknosis and developmental arrest induced by an opioid receptor antagonist and dihydroartemisinin in Plasmodium falciparum. PloS one, 2017, Volume: 12, Issue:9 Topics: Antimalarials; Artemisinins; Benzylidene Compounds; Camphanes; Cannabinoid Receptor Antagonists; Cell Death; Chromatin; Dose-Response Relationship, Drug; Gene Expression Profiling; Glutathione; Naltrexone; Narcotic Antagonists; Oxidation-Reduction; Piperidines; Plasmodium falciparum; Pyrazoles; Rimonabant; Transcriptome	2017
Dual immuno-renal targeting of 7-benzylidenenaltrexone alleviates lupus nephritis via FcγRIIB and HO-1. Journal of molecular medicine (Berlin, Germany), 2018, Volume: 96, Issue:5 Topics: Animals; Autoantibodies; B-Lymphocytes; Benzylidene Compounds; Cell Line; Female; GPI-Linked Proteins; Heme Oxygenase-1; Kidney; Lupus Nephritis; Membrane Proteins; Mice, Inbred MRL lpr; Naltrexone; Receptors, IgG; Spleen	2018
Structure-Activity Relationship between Thiol Group-Trapping Ability of Morphinan Compounds with a Michael Acceptor and Anti- Molecules (Basel, Switzerland), 2020, Mar-02, Volume: 25, Issue:5 Topics: Antimalarials; Benzylidene Compounds; Humans; Morphinans; Naltrexone; Nuclear Magnetic Resonance, Biomolecular; Plasmodium falciparum; Structure-Activity Relationship	2020
The Role of Cardiac Opioid Receptors in the Cardioprotective Effect of Continuous Normobaric Hypoxia. Bulletin of experimental biology and medicine, 2020, Volume: 168, Issue:6 Topics: Adaptation, Physiological; Animals; Benzylidene Compounds; Creatine Kinase; Hypoxia; Male; Myocardial Reperfusion Injury; Myocardium; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Organ Culture Techniques; Peptides; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tetrahydroisoquinolines	2020
Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors. Molecular pharmacology, 1994, Volume: 45, Issue:2 Topics: Analgesics; Animals; Binding Sites; Cell Line; CHO Cells; Cloning, Molecular; Cricetinae; Ligands; PC12 Cells; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Software	1994
Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications. NIDA research monograph, 1998, Volume: 178 Topics: Animals; Aorta, Thoracic; Cocaine; Cyclic AMP; Electric Stimulation; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Mice; Muscle, Smooth; Opioid-Related Disorders; Rats; Receptors, Dopamine; Receptors, Opioid; Receptors, Serotonin; Substance-Related Disorders	1998