naltrexone and 4-(alpha-(4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl)-n,n-diethylbenzamide

naltrexone has been researched along with 4-(alpha-(4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl)-n,n-diethylbenzamide in 57 studies

Research

Studies (57)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	9 (15.79)	18.2507
2000's	34 (59.65)	29.6817
2010's	10 (17.54)	24.3611
2020's	4 (7.02)	2.80

Authors

Authors	Studies
Ananthan, S; Bartlett, JL; Bilsky, EJ; Davis, P; Dersch, CM; Khare, NK; Porreca, F; Rothman, RB; Saini, SK; Seitz, LE	1
Bidlack, JM; Bu, Y; Cohen, DJ; Denhardt, C; Ganorkar, R; Guo, C; Jin, J; Lou, R; Lu, Q; VanAlstine, MA; Wentland, MP	1
England, PM; Harvey, JH; Long, DH; Whistler, JL	1
Iwata, S; Koyama, Y; Kutsumura, N; Miyata, Y; Nagase, H; Nagumo, Y; Nakajima, R; Saitoh, T; Yamamoto, N; Yoshida, N	1
Bernstein, RN; Bilsky, EJ; Calderon, SN; Davis, P; Hruby, VJ; McNutt, RW; Porreca, F; Rice, KC; Rothman, RB; Wang, T	1
Calderon, S; Hruby, VJ; Knapp, RJ; Malatynska, E; Rice, K; Roeske, WR; Waite, S; Wang, Y; Yamamura, HI	1
Burkey, TH; Hosohata, K; Hosohata, Y; Hruby, VJ; Knapp, RJ; Nagase, H; Porreca, F; Quock, RM; Rice, KC; Roeske, WR; Yamamura, HI; Zhang, X	1
Artico, M; Clarke, GD; Dondio, G; Eggleston, DS; Farina, C; Petrillo, P; Petrone, G; Ronzoni, S; Vecchietti, V; Visentin, L	1
Chao, CC; Gekker, G; Li, MD; Peterson, PK; Sharp, BM	1
Kapusta, DR; Kenigs, VA; Sezen, SF	1
Cadoni, C; Di Chiara, G; Longoni, R; Mulas, A; Spina, L	1
Roeske, WR; Rubenzik, M; Stropova, D; Varga, EV; Waite, S; Yamamura, HI	1
Brandt, MR; Furness, MS; Mello, NK; Negus, SS; Rice, KC; Zhang, X	1
Burkey, TH; Cowell, SM; Hruby, VJ; Okura, T; Roeske, WR; Varga, E; Yamamura, HI	1
Broom, DC; Coop, A; Guo, L; Husbands, SM; Lewis, JW; Traynor, JR; Woods, JH	1
Clarke, PB; Ducharme, J; Fraser, GL; Parenteau, H; Perkins, MN; Tu, TM	1
Akil, H; Bonner, G; Meng, F	1
Calderon, SN; Hutchinson, AC; Randall, JF; Rice, KC; Riley, AL; Simpson, GR; Zhang, X	1
Cañadas, F; Rice, KC; Riley, AL; Stevenson, GW; Zhang, X	1
Balboni, G; Bryant, SD; Butterworth, J; Guerrini, R; Labarre, M; Lazarus, LH; Payza, K; Salvadori, S; Schmidhammer, H; St-Onge, S	1
Hosohata, Y; Hruby, VJ; Knapp, RJ; Li, X; Nagase, H; Rice, KC; Roeske, WR; Stropova, D; Varga, EV; Yamamura, HI	1
Ananthan, S; Lu, YF; Rice, KC; Rothman, RB; Xu, H	1
Barn, DR; Caulfield, WL; Cottney, J; McGurk, K; Morphy, JR; Rankovic, Z; Roberts, B	1
Cao, CQ; Dray, A; Hong, YG; Perkins, MN	1
Fiore, P; Gannon, RL; Tierno, A	1
Jones, RM; Linsenmayer, DC; Mello, NK; Negus, SS; Portoghese, PS	1
Broom, DC; Nitsche, JF; Pintar, JE; Rice, KC; Traynor, JR; Woods, JH	1
Cowell, SM; Hosohata, Y; Hruby, VJ; Nagase, H; Navratilova, E; Okura, T; Rice, K; Roeske, WR; Varga, EV; Yamamura, HI	1
Brown, DR; Townsend, DW	1
Folk, JE; Linsenmayer, DC; Negus, SS; Rice, KC; Stevenson, GW	1
Dortch-Carnes, J; Potter, DE	1
Befort, K; Décaillot, FM; Filliol, D; Kieffer, BL; Lazarus, LH; Schiller, PW; Schmidhammer, H; Tryoen-Tóth, P	1
Goldberg, SR; Solinas, M	1
Guo, X; Kelschenbach, J; Liu, Y; Loh, HH; Roy, S	1
Ananthan, S; Caballero-Hernández, D; Gomez-Flores, R; Hicks, ME; Rice, KC; Rodríguez-Padilla, C; Tamez-Guerra, P; Tamez-Guerra, R; Weber, RJ	1
Kamei, J; Onodera, K; Saitoh, A; Yoshikawa, Y	1
Kaneko, C; Kuzumaki, N; Matsuzawa, K; Miyoshi, K; Nagumo, Y; Nakajima, M; Nanjo, K; Narita, M; Suzuki, T; Yamazaki, M	1
Castro, MS; Duarte, ID; Francischi, JN; Pacheco, DF; Perez, AC; Reis, GM	1
Jutkiewicz, EM; Rice, KC; Traynor, JR; Woods, JH	1
Booze, RM; Dodson, SL; Nath, A; Wallace, DR	1
Folk, JE; Jutkiewicz, EM; Mosberg, HI; Rice, KC; Sobczyk-Kojiro, K; Torregrossa, MM; Watson, SJ; Woods, JH	1
Hoshaw, BA; Perrine, SA; Unterwald, EM	1
Herzog, H; Loacker, S; Sayyah, M; Schwarzer, C; Wittmann, W	1
Ito, S; Mori, T; Sawaguchi, T	1
Bosse, KE; Gnegy, ME; Jutkiewicz, EM; Traynor, JR	1
Fukuda, K; Koyama, T	1
Brissett, DI; van Rijn, RM; Whistler, JL	1
Fujii, H; Nagase, H; Nemoto, T; Oka, J; Saitoh, A; Sugiyama, A; Wada, K; Yamada, M	1
Ashraf, M; Higuchi, S; Ii, M; Zhu, P	1
Cahill, CM; Olmstead, MC; Ong, EW; Xue, L	1
Akbari, HA; Cahill, CM; Carroll, FI; Evans, CJ; Lutfy, K; Pradhan, AA; Roberts, KW; Taylor, AM; Walwyn, W	1
Královičová, J; Lacinová, Ľ; Moravčíková, L	1
Nagase, H; Oka, JI; Saitoh, A; Yamada, D; Yanagisawa, S; Yanagita, S; Yoshizawa, K	1
Dasgupta, P; Klima, M; Liebetrau, S; Mann, A; Massotte, D; Schulz, S	1
Chen, R; Disney, A; Dripps, IJ; Husbands, SM; Jutkiewicz, EM; Livingston, KE; Rice, KC; Shafer, AM; Traynor, JR	1
Dremencov, E; Jezova, D; Lacinova, L; Moravcik, R; Moravcikova, L	1
Iio, K; Nagase, H; Nishida, M; Saitoh, A; Sakamoto, K; Yamada, D; Yamanaka, N	1

Other Studies

57 other study(ies) available for naltrexone and 4-(alpha-(4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl)-n,n-diethylbenzamide

Article	Year
Identification of opioid ligands possessing mixed micro agonist/delta antagonist activity among pyridomorphinans derived from naloxone, oxymorphone, and hydromorphone [correction of hydropmorphone]. Journal of medicinal chemistry, 2004, Mar-11, Volume: 47, Issue:6 Topics: Analgesics; Animals; Binding Sites; Brain; Drug Tolerance; Electric Stimulation; Guinea Pigs; Hydromorphone; Ileum; In Vitro Techniques; Ligands; Male; Mice; Mice, Inbred ICR; Morphinans; Muscle Contraction; Muscle, Smooth; Naloxone; Oxymorphone; Pyridines; Radioligand Assay; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Vas Deferens	2004
Syntheses of novel high affinity ligands for opioid receptors. Bioorganic & medicinal chemistry letters, 2009, Apr-15, Volume: 19, Issue:8 Topics: Analgesics, Opioid; Crystallography, X-Ray; Furans; Humans; Ligands; Naltrexone; Narcotic Antagonists; Protein Binding; Receptors, Opioid	2009
Tuned-Affinity Bivalent Ligands for the Characterization of Opioid Receptor Heteromers. ACS medicinal chemistry letters, 2012, Aug-09, Volume: 3, Issue:8 Topics:	2012
Antitrichomonal activity of δ opioid receptor antagonists, 7-benzylidenenaltrexone derivatives. Bioorganic & medicinal chemistry, 2017, 08-15, Volume: 25, Issue:16 Topics: Animals; Antitrichomonal Agents; Benzylidene Compounds; CHO Cells; Cricetulus; Dose-Response Relationship, Drug; Molecular Structure; Naltrexone; Receptors, Opioid, delta; Structure-Activity Relationship; Trichomonas vaginalis	2017
SNC 80, a selective, nonpeptidic and systemically active opioid delta agonist. The Journal of pharmacology and experimental therapeutics, 1995, Volume: 273, Issue:1 Topics: Analgesics; Animals; Behavior, Animal; Benzamides; Guinea Pigs; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Naltrexone; Piperazines; Radioligand Assay; Receptors, Opioid, delta	1995
Human delta opioid receptor: functional studies on stably transfected Chinese hamster ovary cells after acute and chronic treatment with the selective nonpeptidic agonist SNC-80. The Journal of pharmacology and experimental therapeutics, 1996, Volume: 278, Issue:3 Topics: Animals; Benzamides; Binding, Competitive; CHO Cells; Cricetinae; Cyclic AMP; Down-Regulation; Humans; Naltrexone; Piperazines; Radioligand Assay; Receptors, Opioid, delta; Recombinant Proteins; Signal Transduction; Structure-Activity Relationship; Transfection	1996
Relative efficacies of delta-opioid receptor agonists at the cloned human delta-opioid receptor. European journal of pharmacology, 1997, May-12, Volume: 326, Issue:1 Topics: Animals; Benzamides; CHO Cells; Cloning, Molecular; Cricetinae; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Naltrexone; Narcotic Antagonists; Piperazines; Quinolines; Receptors, Opioid, delta; Sulfur Radioisotopes	1997
Discovery of a novel class of substituted pyrrolooctahydroisoquinolines as potent and selective delta opioid agonists, based on an extension of the message-address concept. Journal of medicinal chemistry, 1997, Sep-26, Volume: 40, Issue:20 Topics: Animals; Benzamides; Brain; Computer Simulation; Dose-Response Relationship, Drug; Drug Design; Enkephalin, Leucine-2-Alanine; Indoles; Isoquinolines; Ligands; Male; Mice; Models, Molecular; Naltrexone; Narcotic Antagonists; Nociceptors; Piperazines; Pyrroles; Quinolines; Receptors, Opioid, delta; Signal Transduction; Stereoisomerism; Vas Deferens	1997
Delta-opioid suppression of human immunodeficiency virus-1 expression in T cells (Jurkat). Biochemical pharmacology, 1998, Aug-01, Volume: 56, Issue:3 Topics: Benzamides; HIV-1; Humans; Jurkat Cells; Naltrexone; Oligopeptides; Piperazines; Receptors, Opioid, delta; T-Lymphocytes	1998
Renal excretory responses produced by the delta opioid agonist, BW373U86, in conscious rats. The Journal of pharmacology and experimental therapeutics, 1998, Volume: 287, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzamides; Denervation; Infusions, Intravenous; Kidney; Male; Naltrexone; Oligopeptides; Opioid Peptides; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta	1998
Dopamine-dependent behavioural stimulation by non-peptide delta opioids BW373U86 and SNC 80: 2. Place-preference and brain microdialysis studies in rats. Behavioural pharmacology, 1998, Volume: 9, Issue:1 Topics: Animals; Behavior, Animal; Benzamides; Benzazepines; Brain Chemistry; Caudate Nucleus; Conditioning, Operant; Dopamine; Dopamine Antagonists; Extracellular Space; Male; Microdialysis; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Piperazines; Rats; Rats, Sprague-Dawley	1998
Phosphorylation of adenylyl cyclase VI upon chronic delta-opioid receptor stimulation. European journal of pharmacology, 1999, Jan-08, Volume: 364, Issue:2-3 Topics: Adenylyl Cyclases; Animals; Benzamides; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Naltrexone; Narcotic Antagonists; Phosphorylation; Piperazines; Receptors, Opioid, delta; Time Factors	1999
Discriminative stimulus effects of the nonpeptidic delta-opioid agonist SNC80 in rhesus monkeys. The Journal of pharmacology and experimental therapeutics, 1999, Volume: 290, Issue:3 Topics: Analgesics, Opioid; Animals; Azocines; Benzamides; Discrimination Learning; Dose-Response Relationship, Drug; Female; Macaca mulatta; Male; Naltrexone; Narcotic Antagonists; Piperazines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stereoisomerism	1999
Differential down-regulation of the human delta-opioid receptor by SNC80 and [D-Pen(2),D-Pen(5)]enkephalin. European journal of pharmacology, 2000, Jan-10, Volume: 387, Issue:2 Topics: Benzamides; Down-Regulation; Enkephalin, D-Penicillamine (2,5)-; Humans; Naltrexone; Piperazines; Receptors, Opioid, delta	2000
BU48: a novel buprenorphine analog that exhibits delta-opioid-mediated convulsions but not delta-opioid-mediated antinociception in mice. The Journal of pharmacology and experimental therapeutics, 2000, Volume: 294, Issue:3 Topics: Analgesics, Opioid; Animals; Benzamides; Brain; Buprenorphine; Convulsants; Electric Stimulation; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Muscle Contraction; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Pain Measurement; Piperazines; Radioligand Assay; Rats; Receptors, Opioid, delta; Receptors, Opioid, kappa; Seizures; Vas Deferens	2000
The effects of delta agonists on locomotor activity in habituated and non-habituated rats. Life sciences, 2000, Jul-14, Volume: 67, Issue:8 Topics: Animals; Benzamides; Dose-Response Relationship, Drug; Drug Tolerance; Male; Motor Activity; Naltrexone; Oligopeptides; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta	2000
Selectivity of mu-opioid receptor determined by interfacial residues near third extracellular loop. European journal of pharmacology, 2000, Sep-01, Volume: 403, Issue:1-2 Topics: Amino Acid Substitution; Animals; Benzamides; Benzomorphans; Binding Sites; Binding, Competitive; COS Cells; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Fentanyl; Guanosine 5'-O-(3-Thiotriphosphate); Ligands; Morphine; Mutation; Naloxone; Naltrexone; Narcotic Antagonists; Peptides; Piperazines; Protein Conformation; Radioligand Assay; Rats; Receptors, Opioid, mu; Signal Transduction; Sulfur Radioisotopes	2000
Assessment of SNC 80 and naltrindole within a conditioned taste aversion design. Pharmacology, biochemistry, and behavior, 2000, Volume: 66, Issue:4 Topics: Animals; Avoidance Learning; Benzamides; Conditioning, Operant; Dose-Response Relationship, Drug; Female; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Piperazines; Rats; Rats, Long-Evans; Receptors, Opioid, delta; Saccharin; Sweetening Agents; Taste	2000
Morphine discriminative control is mediated by the mu opioid receptor: assessment of delta opioid substitution and antagonism. Pharmacology, biochemistry, and behavior, 2000, Volume: 66, Issue:4 Topics: Animals; Benzamides; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Female; Generalization, Response; Methadone; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Piperazines; Rats; Rats, Long-Evans; Receptors, Opioid, delta; Receptors, Opioid, mu	2000
Inverse agonism by Dmt-Tic analogues and HS 378, a naltrindole analogue. European journal of pharmacology, 2000, Oct-06, Volume: 406, Issue:1 Topics: Benzamides; Benzeneacetamides; Binding, Competitive; Cell Line; Cell Membrane; Dipeptides; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Isoquinolines; Naltrexone; Narcotic Antagonists; Piperazines; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sulfur Radioisotopes; Tetrahydroisoquinolines	2000
Mutation W284L of the human delta opioid receptor reveals agonist specific receptor conformations for G protein activation. Life sciences, 2001, Apr-06, Volume: 68, Issue:19-20 Topics: Animals; Benzamides; Binding Sites; CHO Cells; Cricetinae; DNA Primers; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Indoles; Intracellular Membranes; Isoquinolines; Morpholines; Mutagenesis, Site-Directed; Naltrexone; Piperazines; Point Mutation; Protein Conformation; Quinolines; Receptors, Opioid, delta; Sulfur Radioisotopes	2001
SoRI 9409, a non-peptide opioid mu receptor agonist/delta receptor antagonist, fails to stimulate [35S]-GTP-gamma-S binding at cloned opioid receptors. Brain research bulletin, 2001, Jul-01, Volume: 55, Issue:4 Topics: Analgesics; Analgesics, Opioid; Animals; Benzamides; Benzeneacetamides; Binding, Competitive; CHO Cells; Cloning, Molecular; Cricetinae; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Iodine Radioisotopes; Morphine; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Piperazines; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sulfur Radioisotopes; Tritium	2001
Parallel synthesis and biological activity of a new class of high affinity and selective delta-opioid ligand. Bioorganic & medicinal chemistry, 2001, Volume: 9, Issue:10 Topics: Amides; Analgesics, Opioid; Animals; Benzamides; Brain; Catalysis; Combinatorial Chemistry Techniques; Guinea Pigs; Humans; Inhibitory Concentration 50; Isoquinolines; Ligands; Male; Maleimides; Membrane Proteins; Mice; Mice, Inbred ICR; Molecular Structure; Morphine; Naltrexone; Nerve Tissue Proteins; Pain Measurement; Phthalimides; Piperazines; Quinolines; Rats; Rats, Wistar; Receptors, Opioid, delta; Structure-Activity Relationship; Succinimides; Sulfonamides	2001
Selective depression of nociceptive responses of dorsal horn neurones by SNC 80 in a perfused hindquarter preparation of adult mouse. Neuroscience, 2001, Volume: 107, Issue:2 Topics: Action Potentials; Animals; Benzamides; In Vitro Techniques; Male; Mice; Naltrexone; Narcotic Antagonists; Pain; Piperazines; Posterior Horn Cells; Receptors, Opioid, delta	2001
Delta opioid inhibition of light-induced phase advances in hamster circadian activity rhythms. Brain research, 2002, May-24, Volume: 937, Issue:1-2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzamides; Biological Clocks; Circadian Rhythm; Cricetinae; Enkephalins; Light; Male; Mesocricetus; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Nerve Tissue Proteins; Opioid Peptides; Piperazines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Suprachiasmatic Nucleus	2002
Kappa opioid antagonist effects of the novel kappa antagonist 5'-guanidinonaltrindole (GNTI) in an assay of schedule-controlled behavior in rhesus monkeys. Psychopharmacology, 2002, Volume: 163, Issue:3-4 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Non-Narcotic; Animals; Benzamides; Benzeneacetamides; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Interactions; Female; Guanidines; Macaca mulatta; Male; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Piperazines; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Reinforcement Schedule; Time Factors	2002
Comparison of receptor mechanisms and efficacy requirements for delta-agonist-induced convulsive activity and antinociception in mice. The Journal of pharmacology and experimental therapeutics, 2002, Volume: 303, Issue:2 Topics: Analgesics; Analgesics, Opioid; Animals; Benzamides; Benzylidene Compounds; Convulsants; Drug Tolerance; Enkephalin, D-Penicillamine (2,5)-; Male; Mice; Mice, Knockout; Naltrexone; Narcotic Antagonists; Piperazines; Receptors, Opioid, delta	2002
Agonist-specific down-regulation of the human delta-opioid receptor. European journal of pharmacology, 2003, Jan-10, Volume: 459, Issue:1 Topics: Amino Acid Sequence; Analgesics, Opioid; Animals; Benzamides; Binding, Competitive; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Down-Regulation; Enkephalin, D-Penicillamine (2,5)-; Humans; Molecular Sequence Data; Naltrexone; Pertussis Toxin; Phosphorylation; Piperazines; Radioligand Assay; Receptors, Opioid, delta; Recombinant Fusion Proteins; Sequence Deletion; Tritium	2003
Pharmacological characterization of a 7-benzylidenenaltrexone-preferring opioid receptor in porcine ileal submucosa. British journal of pharmacology, 2003, Volume: 140, Issue:4 Topics: Amphibian Proteins; Animals; Anions; Benzamides; Benzylidene Compounds; Biological Transport, Active; Carrier Proteins; Diprenorphine; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Female; Gastrointestinal Motility; Ileum; Intestinal Mucosa; Male; Naltrexone; Neurons, Afferent; Oligopeptides; Piperazines; Quinolines; Receptors, Opioid, delta; Receptors, Opioid, mu; Swine; Tritium	2003
Opioid interactions in rhesus monkeys: effects of delta + mu and delta + kappa agonists on schedule-controlled responding and thermal nociception. The Journal of pharmacology and experimental therapeutics, 2003, Volume: 307, Issue:3 Topics: Analgesics, Opioid; Animals; Benzamides; Benzeneacetamides; Benzomorphans; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Interactions; Hot Temperature; Macaca mulatta; Male; Naltrexone; Narcotic Antagonists; Pain; Piperazines; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reinforcement Schedule	2003
Delta-opioid agonist-stimulated inositol phosphate formation in isolated, rabbit iris-ciliary bodies: role of G(i/o) proteins and Gbetagamma-subunits. Experimental eye research, 2003, Volume: 77, Issue:6 Topics: Animals; Benzamides; Chromatography, Ion Exchange; Ciliary Body; Dose-Response Relationship, Drug; Eye Proteins; GTP-Binding Protein Regulators; GTP-Binding Proteins; Inositol Phosphates; Iris; Naltrexone; Narcotic Antagonists; Pertussis Toxin; Phosphoproteins; Piperazines; Rabbits; Receptors, Opioid, delta	2003
Inverse agonism and neutral antagonism at wild-type and constitutively active mutant delta opioid receptors. The Journal of pharmacology and experimental therapeutics, 2005, Volume: 313, Issue:1 Topics: Alkaline Phosphatase; Benzamides; Cell Line; Dipeptides; Dose-Response Relationship, Drug; Enkephalin, Leucine; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Ligands; Mutation; Naltrexone; Narcotic Antagonists; Piperazines; Receptors, Opioid, delta; Structure-Activity Relationship	2005
Involvement of mu-, delta- and kappa-opioid receptor subtypes in the discriminative-stimulus effects of delta-9-tetrahydrocannabinol (THC) in rats. Psychopharmacology, 2005, Volume: 179, Issue:4 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Benzamides; Conditioning, Operant; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Food; Hallucinogens; Heroin; Male; Naltrexone; Narcotic Antagonists; Narcotics; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reinforcement, Psychology	2005
In vivo activation of a mutant mu-opioid receptor by naltrexone produces a potent analgesic effect but no tolerance: role of mu-receptor activation and delta-receptor blockade in morphine tolerance. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005, Mar-23, Volume: 25, Issue:12 Topics: Animals; Benzamides; Dose-Response Relationship, Drug; Drug Delivery Systems; Drug Interactions; Drug Tolerance; Mice; Mice, Transgenic; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Pain Measurement; Piperazines; Receptors, Opioid, mu	2005
Potentiation of rat lymphocyte proliferation by novel non-peptidic synthetic opioids. International immunopharmacology, 2005, Volume: 5, Issue:7-8 Topics: Adjuvants, Immunologic; Animals; Benzamides; Concanavalin A; Dose-Response Relationship, Drug; Lymphocyte Activation; Male; Naltrexone; Narcotics; Piperazines; Rats; Rats, Sprague-Dawley	2005
Role of delta-opioid receptor subtypes in anxiety-related behaviors in the elevated plus-maze in rats. Psychopharmacology, 2005, Volume: 182, Issue:3 Topics: Animals; Anxiety; Benzamides; Benzylidene Compounds; Blood Specimen Collection; Corticosterone; Male; Maze Learning; Naltrexone; Piperazines; Rats; Rats, Inbred Lew; Receptors, Opioid, delta	2005
Chronic pain induces anxiety with concomitant changes in opioidergic function in the amygdala. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2006, Volume: 31, Issue:4 Topics: Amygdala; Analgesics, Opioid; Analysis of Variance; Animals; Anxiety; Behavior, Animal; Benzamides; Chronic Disease; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Freund's Adjuvant; Guanosine 5'-O-(3-Thiotriphosphate); Injections, Intraventricular; Male; Maze Learning; Mice; Mice, Inbred C57BL; Naltrexone; Narcotic Antagonists; Narcotics; Pain; Pain Measurement; Piperazines; Protein Binding; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reaction Time; Sciatica; Somatostatin; Sulfur Isotopes; Time Factors; Tranquilizing Agents	2006
delta-Opioid receptor agonist SNC80 elicits peripheral antinociception via delta(1) and delta(2) receptors and activation of the l-arginine/nitric oxide/cyclic GMP pathway. Life sciences, 2005, Nov-19, Volume: 78, Issue:1 Topics: Analgesics; Animals; Arginine; Benzamides; Benzylidene Compounds; Cyclic GMP; Dinoprostone; Enzyme Inhibitors; Hyperalgesia; Male; Naltrexone; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Piperazines; Rats; Receptors, Opioid, delta	2005
Separation of the convulsions and antidepressant-like effects produced by the delta-opioid agonist SNC80 in rats. Psychopharmacology, 2005, Volume: 182, Issue:4 Topics: Analysis of Variance; Animals; Antidepressive Agents; Behavior, Animal; Benzamides; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Interactions; Male; Naltrexone; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Restraint, Physical; Seizures; Swimming; Time Factors; Tritium	2005
Delta opioid agonists attenuate TAT(1-72)-induced oxidative stress in SK-N-SH cells. Neurotoxicology, 2006, Volume: 27, Issue:1 Topics: Benzamides; Cell Line, Tumor; Cell Membrane; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Fluoresceins; Free Radicals; Gene Products, tat; Humans; Molsidomine; Naltrexone; Narcotic Antagonists; Opioid Peptides; Oxidative Stress; Piperazines; Receptors, Opioid, delta; tat Gene Products, Human Immunodeficiency Virus	2006
Behavioral and neurobiological effects of the enkephalinase inhibitor RB101 relative to its antidepressant effects. European journal of pharmacology, 2006, Feb-15, Volume: 531, Issue:1-3 Topics: Adrenocorticotropic Hormone; Animals; Antidepressive Agents; Behavior, Animal; Benzamides; Brain-Derived Neurotrophic Factor; Disulfides; Dose-Response Relationship, Drug; Electroencephalography; Enzyme Inhibitors; Frontal Lobe; Hippocampus; Injections, Intravenous; Male; Motor Activity; Naltrexone; Narcotic Antagonists; Neprilysin; Phenylalanine; Piperazines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Swimming	2006
Delta opioid receptor ligands modulate anxiety-like behaviors in the rat. British journal of pharmacology, 2006, Volume: 147, Issue:8 Topics: Animals; Anti-Anxiety Agents; Anxiety; Benzamides; Dose-Response Relationship, Drug; Male; Naltrexone; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta	2006
Endogenous dynorphin in epileptogenesis and epilepsy: anticonvulsant net effect via kappa opioid receptors. Brain : a journal of neurology, 2007, Volume: 130, Issue:Pt 4 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzamides; Cell Count; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Epilepsy, Temporal Lobe; Guanidines; Hippocampus; Kindling, Neurologic; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphinans; Naltrexone; Nerve Degeneration; Piperazines; Protein Precursors; Receptors, Opioid, kappa; Synaptic Transmission; Time Factors	2007
Dopamine-independent psychostimulant activity of a delta-agonist. Behavioural pharmacology, 2008, Volume: 19, Issue:2 Topics: Animals; Benzamides; Brain; Central Nervous System Stimulants; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Synergism; Haloperidol; Male; Mice; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Piperazines; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Opioid, delta	2008
The selective delta opioid agonist SNC80 enhances amphetamine-mediated efflux of dopamine from rat striatum. Neuropharmacology, 2008, Volume: 55, Issue:5 Topics: Amphetamine; Analgesics, Opioid; Analysis of Variance; Animals; Area Under Curve; Benzamides; Corpus Striatum; Dopamine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Male; Naltrexone; Narcotic Antagonists; Piperazines; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Subcellular Fractions; Time Factors; Tritium	2008
Involvement of the kappa-opioid receptor in nitrous oxide-induced analgesia in mice. Journal of anesthesia, 2010, Volume: 24, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics, Non-Narcotic; Animals; Benzamides; Male; Mice; Mice, Inbred C57BL; Naltrexone; Narcotic Antagonists; Nitrous Oxide; Pain; Piperazines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Treatment Outcome	2010
Dual efficacy of delta opioid receptor-selective ligands for ethanol drinking and anxiety. The Journal of pharmacology and experimental therapeutics, 2010, Volume: 335, Issue:1 Topics: Alcohol Deterrents; Alcohol Drinking; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Benzamides; Diazepam; Ligands; Mice; Mice, Inbred C57BL; Mice, Knockout; Naltrexone; Narcotic Antagonists; Piperazines; Quinolines; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Opioid, delta; Substance Withdrawal Syndrome	2010
The novel δ opioid receptor agonist KNT-127 produces antidepressant-like and antinociceptive effects in mice without producing convulsions. Behavioural brain research, 2011, Oct-01, Volume: 223, Issue:2 Topics: Analgesics; Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Behavior, Animal; Benzamides; Depression; Dopamine Antagonists; Imipramine; Male; Mice; Mice, Inbred ICR; Morphinans; Motor Activity; Naltrexone; Narcotic Antagonists; Pain Measurement; Piperazines; Receptors, Opioid, delta; Seizures; Swimming	2011
Delta-opioid receptor activation promotes mesenchymal stem cell survival via PKC/STAT3 signaling pathway. Circulation journal : official journal of the Japanese Circulation Society, 2012, Volume: 76, Issue:1 Topics: Animals; Benzamides; Cell Survival; Cells, Cultured; Dactinomycin; Male; Mesenchymal Stem Cells; Models, Animal; Myeloid Cell Leukemia Sequence 1 Protein; Naltrexone; Piperazines; Protein Kinase C; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Inbred F344; Receptors, Opioid, delta; Signal Transduction; STAT3 Transcription Factor	2012
Prolonged morphine treatment alters δ opioid receptor post-internalization trafficking. British journal of pharmacology, 2015, Volume: 172, Issue:2 Topics: Analgesics, Opioid; Animals; Benzamides; Cells, Cultured; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Ganglia, Spinal; Male; Mice, Knockout; Morphine; Naltrexone; Neurons; Oligopeptides; Piperazines; Protein Transport; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu	2015
Anti-nociception mediated by a κ opioid receptor agonist is blocked by a δ receptor agonist. British journal of pharmacology, 2015, Volume: 172, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Behavior, Animal; Benzamides; Diazepam; Etorphine; Female; Hot Temperature; Male; Mice, Inbred C57BL; Mice, Knockout; Naltrexone; Nociceptin Receptor; Nociception; Piperazines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stress, Psychological	2015
SNC80 and naltrindole modulate voltage-dependent sodium, potassium and calcium channels via a putatively delta opioid receptor-independent mechanism. General physiology and biophysics, 2018, Volume: 37, Issue:3 Topics: Benzamides; Calcium Channels; Cell Line; Dose-Response Relationship, Drug; Electrophysiological Phenomena; Gene Expression Regulation; Ion Channels; Naltrexone; Neurons; Piperazines; Potassium Channels; Receptors, Opioid, delta; Sodium Channels	2018
Selective agonists of the δ-opioid receptor, KNT-127 and SNC80, act differentially on extinction learning of contextual fear memory in mice. Neuropharmacology, 2019, 12-01, Volume: 160 Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Benzamides; Conditioning, Psychological; Extinction, Psychological; Fear; Learning; Male; Memory; Mice; Morphinans; Motor Activity; Naltrexone; Piperazines; Receptors, Opioid, delta	2019
Agonist-induced phosphorylation bar code and differential post-activation signaling of the delta opioid receptor revealed by phosphosite-specific antibodies. Scientific reports, 2020, 05-22, Volume: 10, Issue:1 Topics: Animals; Antibodies, Monoclonal; Benzamides; HEK293 Cells; Humans; Mice; Naltrexone; Narcotic Antagonists; Oligopeptides; Phosphorylation; Piperazines; Receptors, Opioid, delta; Signal Transduction	2020
Pharmacological Properties of The Journal of pharmacology and experimental therapeutics, 2020, Volume: 374, Issue:2 Topics: Animals; Behavior, Animal; Benzamides; Buprenorphine; Drug Partial Agonism; Mice; Naltrexone; Piperazines; Receptors, Opioid, delta	2020
Delta-opioid receptor-mediated modulation of excitability of individual hippocampal neurons: mechanisms involved. Pharmacological reports : PR, 2021, Volume: 73, Issue:1 Topics: Action Potentials; Animals; Behavior, Animal; Benzamides; Calcium Channels; Female; Hippocampus; Naltrexone; Narcotic Antagonists; Neurons; Piperazines; Potassium Channels; Primary Cell Culture; Rats; Rats, Wistar; Receptors, Opioid, delta; Sodium Channels	2021
A selective delta opioid receptor agonist SNC80, but not KNT-127, induced tremor-like behaviors via hippocampal glutamatergic system in mice. Brain research, 2021, 04-15, Volume: 1757 Topics: Analgesics, Opioid; Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Behavior, Animal; Benzamides; Hippocampus; Insular Cortex; Mice; Morphinans; Motor Activity; Naltrexone; Piperazines; Receptors, Opioid, delta	2021