nalmefene and naloxone

nalmefene has been researched along with naloxone in 61 studies

Research

Studies (61)

Timeframe	Studies, this research(%)	All Research%
pre-1990	22 (36.07)	18.7374
1990's	24 (39.34)	18.2507
2000's	6 (9.84)	29.6817
2010's	6 (9.84)	24.3611
2020's	3 (4.92)	2.80

Authors

Authors	Studies
Cantrell, BE; Johnson, BG; Leander, JD; Mendelsohn, LG; Mitch, CH; Reel, JK; Shaw, WN; Snoddy, JD; Takemori, AE; Wong, DT	1
Adapa, ID; Auh, JS; Berzetei-Gurske, IP; Brandt, SR; Craymer, K; Farrington, L; Haggart, D; Kennedy, JM; O'Brien, A; Polgar, WE; Rodriguez, L; Schwartz, RW; Toll, L; White, A	1
Strassburg, CP; Tukey, RH	1
Lombardo, F; Obach, RS; Waters, NJ	1
Bidlack, JM; Bu, Y; Cohen, DJ; Lou, R; Lu, Q; VanAlstine, MA; Wentland, MP	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Benzel, EC; Fowler, MR; Khare, V	1
Bergasa, NV; Jones, EA	1
de Zwaan, M; Mitchell, JE	1
Lopez, J; Naujokat, P; Toledo-Pereyra, LH; Walters, W; Xavier, R	2
Reid, RL; Vanvugt, DA; Webb, MY	2
France, CP; Morse, WH	1
Barsan, WG; Bartlett, R; Bryan, C; Buncher, R; Danzl, DF; Ling, LJ; Seger, D	1
Bardin, CW; Belhadj, H; de Besi, L; Thau, RB	1
Gentle, MJ; Savory, CJ; Yeomans, MR	1
Bardin, CW; Boitani, C; Chen, CL; Gerendai, I; Margioris, AN; Morris, PL	1
Bolger, G; Michel, ME; Weissman, BA	1
Altman, DG; Barrowcliffe, MP; Jones, JG; Jordan, C; Konieczko, KM	1
Dixon, R; Simpkins, JW; Smulkowski, M; Tuttle, R	1
Fishman, J; Lustig, RH; Pfaff, DW	1
Bittle, JB; Givens, JR; Howes, JF; Karas, JG; Kitabchi, AE; Kurtz, BR; Mitchell, JA	1
Arteau, C; Fujimoto, JM; Roerig, SC	1
Cherkin, A; Flood, JF; Morley, JE	1
Bardin, CW; Gerendai, I; Gunsalus, GL; Shaha, C	1
Court, MH; Dixon, R; Dodman, NH; Shuster, L	1
Bardin, CW; Hahn, EF; Limonta, P; Thau, RB	1
Dixon, R; Hahn, E; Hsiao, J; Taaffe, W; Tuttle, R	1
Bodor, N; Katovich, MJ; Simpkins, JW; Song, IC; Tuttle, R	1
Bardin, CW; Gerendai, I; Shaha, C; Thau, R	1
Baile, CA; McLaughlin, CL	1
Dixon, R; Hsiao, J	1
Culpepper-Morgan, JA; Holt, PR; Kreek, MJ; LaRoche, D	1
Rault, B; Saiag, B; Shacoori, V	1
Fujimoto, JM; Holmes, BB	1
Glass, PS; Jhaveri, RM; Smith, LR	1
Casper, RF; Graves, GR; Kennedy, TG; Weick, RF	1
Rust, M	1
Cobbe, SM; Hicks, MN; Oldroyd, KG	1
Osifchin, E; Veng-Pedersen, P; Waters, SJ; Wilhelm, JA; Zakszewski, TB	2
Girre, A; Lemay, V; Rault, B; Saïag, B; Shacoori, V	1
Civelek, AC; Dannals, RF; Dixon, RB; Joh, T; Kao, PF; Kim, S; Ravert, HT; Villemagne, VL; Wagner, HN	1
Borg, L; Gunduz, M; Ho, A; King, A; Kreek, MJ; Maniar, S; Perret, G; Porter, M; Schluger, JH	1
Borg, L; Gunduz, M; Ho, A; Kreek, MJ; Schluger, J	1
Chumpa, A	1
Calabro, JJ; Gaddis, GM; Gin-Shaw, SL; Harchelroad, FP; Kaplan, JL; Marx, JA; Spiller, JD; Spivey, WL; Zhao, N	1
Cullen, DJ; Dwyer, MJ; Gold, CG; Gonzales, S; Houtmeyers, D	1
Inagaki, N; Kawasaki, H; Nagai, H; Nagao, M; Nakamura, N	1
Bilsky, EJ; Raehal, KM; Sadée, W; Wang, D	1
Ali, R; Gowing, L; White, JM	1
Bernhard, JD; Luger, TA; Phan, NQ; Ständer, S	1
Bullmore, ET; Felici, A; Henderson, G; Kelly, E; Maltby, K; Mundell, SJ; Nathan, PJ; Roth, AL; Sava, A	1
Allen, AR; Balleine, B; Carter, A; Clark, L; Dowling, NA; Gainsbury, SM; Goudriaan, AE; Grant, J; Hall, W; Hayes, A; Hodgins, D; Lattimore, R; Livingstone, C; Lorenzetti, V; Lubman, D; Murawski, C; Parkes, L; Petry, N; Room, R; Singh, B; Thomas, A; Townshend, P; van Holst, R; Youssef, G; Yücel, M	1
Gil, A; Guerri, C; Montesinos, J	1
García, MC	1
Narayan, RJ; Papich, MG	1

Reviews

8 review(s) available for nalmefene and naloxone

Article	Year
Human UDP-glucuronosyltransferases: metabolism, expression, and disease. Annual review of pharmacology and toxicology, 2000, Volume: 40 Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic	2000
Opiate antagonists and eating behavior in humans: a review. Journal of clinical pharmacology, 1992, Volume: 32, Issue:12 Topics: Appetite Depressants; Dose-Response Relationship, Drug; Eating; Feeding and Eating Disorders; Feeding Behavior; Female; Humans; Male; Naloxone; Naltrexone; Narcotic Antagonists; Obesity	1992
[Prevention of undesirable effects during the use of opiate antagonists]. Klinische Anasthesiologie und Intensivtherapie, 1993, Volume: 42 Topics: Humans; Naloxone; Naltrexone; Narcotic Antagonists	1993
Nalmefene hydrochloride. Pediatric emergency care, 1999, Volume: 15, Issue:2 Topics: Clinical Trials as Topic; Drug Overdose; Half-Life; Humans; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics	1999
Opioid antagonists under heavy sedation or anaesthesia for opioid withdrawal. The Cochrane database of systematic reviews, 2010, Jan-20, Issue:1 Topics: Anesthetics; Humans; Hypnotics and Sedatives; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Randomized Controlled Trials as Topic; Substance Withdrawal Syndrome	2010
Antipruritic treatment with systemic μ-opioid receptor antagonists: a review. Journal of the American Academy of Dermatology, 2010, Volume: 63, Issue:4 Topics: Administration, Oral; Antipruritics; Chronic Disease; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Male; Naloxone; Naltrexone; Pruritus; Randomized Controlled Trials as Topic; Receptors, Opioid, mu; Risk Assessment; Severity of Illness Index; Treatment Outcome	2010
Neuroscience in gambling policy and treatment: an interdisciplinary perspective. The lancet. Psychiatry, 2017, Volume: 4, Issue:6 Topics: Administrative Personnel; Appetite Depressants; Decision Making; Diagnostic and Statistical Manual of Mental Disorders; Disruptive, Impulse Control, and Conduct Disorders; Gambling; Harm Reduction; Humans; Naloxone; Naltrexone; Narcotic Antagonists; Neurosciences; Public Health	2017
[Treatment of borderline personality disorder with opioid antagonists: buprenorphine, nalmefene, naloxone and naltrexone in the treatment of dissociative symptoms, self-mutilation and suicidal behavior]. Vertex (Buenos Aires, Argentina), 2020, Volume: XXX, Issue:148 Topics: Borderline Personality Disorder; Buprenorphine; Dissociative Disorders; Humans; Naloxone; Naltrexone; Narcotic Antagonists; Observational Studies as Topic; Self Mutilation; Suicidal Ideation	2020

Trials

9 trial(s) available for nalmefene and naloxone

Article	Year
Duration of antagonistic effects of nalmefene and naloxone in opiate-induced sedation for emergency department procedures. The American journal of emergency medicine, 1989, Volume: 7, Issue:2 Topics: Adolescent; Adult; Aged; Attention; Consciousness; Double-Blind Method; Emergency Service, Hospital; Female; Humans; Male; Meperidine; Middle Aged; Multicenter Studies as Topic; Naloxone; Naltrexone; Random Allocation	1989
Antagonism of morphine-induced respiratory depression with nalmefene. British journal of anaesthesia, 1988, Volume: 61, Issue:3 Topics: Adult; Carbon Dioxide; Depression, Chemical; Humans; Male; Middle Aged; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Partial Pressure; Respiration; Time Factors	1988
Reduction of hyperinsulinemia and insulin resistance by opiate receptor blockade in the polycystic ovary syndrome with acanthosis nigricans. The Journal of clinical endocrinology and metabolism, 1987, Volume: 64, Issue:2 Topics: Acanthosis Nigricans; Adolescent; Adult; Blood Glucose; Female; Humans; Insulin; Insulin Resistance; Naloxone; Naltrexone; Narcotic Antagonists; Polycystic Ovary Syndrome	1987
Comparison of potency and duration of action of nalmefene and naloxone. Anesthesia and analgesia, 1994, Volume: 78, Issue:3 Topics: Adult; Double-Blind Method; Humans; Male; Naloxone; Naltrexone; Narcotic Antagonists; Reference Values; Time Factors	1994
Longer occupancy of opioid receptors by nalmefene compared to naloxone as measured in vivo by a dual-detector system. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1997, Volume: 38, Issue:11 Topics: Adult; Analgesics, Opioid; Brain; Carbon Radioisotopes; Cross-Over Studies; Female; Fentanyl; Humans; Male; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Time Factors; Tomography, Emission-Computed	1997
Dynorphin A1-13 causes elevation of serum levels of prolactin through an opioid receptor mechanism in humans: gender differences and implications for modulation of dopaminergic tone in the treatment of addictions. The Journal of pharmacology and experimental therapeutics, 1999, Volume: 288, Issue:1 Topics: Adult; Analgesics, Opioid; Analysis of Variance; Cocaine-Related Disorders; Dose-Response Relationship, Drug; Dynorphins; Female; Humans; Male; Middle Aged; Naloxone; Naltrexone; Narcotic Antagonists; Peptide Fragments; Prolactin; Receptors, Dopamine; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sex Characteristics; Time Factors	1999
Double-blind, randomized study of nalmefene and naloxone in emergency department patients with suspected narcotic overdose. Annals of emergency medicine, 1999, Volume: 34, Issue:1 Topics: Adult; Double-Blind Method; Drug Overdose; Emergency Treatment; Humans; Injections, Intravenous; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Neurologic Examination; Respiration; Time Factors; Treatment Outcome	1999
Rapid opioid detoxification during general anesthesia: a review of 20 patients. Anesthesiology, 1999, Volume: 91, Issue:6 Topics: Adult; Anesthesia, General; Combined Modality Therapy; Female; Humans; Male; Middle Aged; Monitoring, Physiologic; Naloxone; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Substance Withdrawal Syndrome	1999
Naloxone and nalmefene absorption delivered by hollow microneedles compared to intramuscular injection. Drug delivery and translational research, 2022, Volume: 12, Issue:2 Topics: Analgesics, Opioid; Animals; Cross-Over Studies; Dogs; Humans; Injections, Intramuscular; Naloxone; Naltrexone; Narcotic Antagonists	2022

Other Studies

44 other study(ies) available for nalmefene and naloxone

Article	Year
3,4-Dimethyl-4-(3-hydroxyphenyl)piperidines: opioid antagonists with potent anorectant activity. Journal of medicinal chemistry, 1993, Oct-01, Volume: 36, Issue:20 Topics: Analgesia; Animals; Appetite Depressants; Cyclohexanes; Diuresis; Eating; Endorphins; Guinea Pigs; Male; Mice; Molecular Structure; Piperidines; Rats; Rats, Sprague-Dawley; Rats, Zucker; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship	1993
Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications. NIDA research monograph, 1998, Volume: 178 Topics: Animals; Aorta, Thoracic; Cocaine; Cyclic AMP; Electric Stimulation; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Mice; Muscle, Smooth; Opioid-Related Disorders; Rats; Receptors, Dopamine; Receptors, Opioid; Receptors, Serotonin; Substance-Related Disorders	1998
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Syntheses and opioid receptor binding properties of carboxamido-substituted opioids. Bioorganic & medicinal chemistry letters, 2009, Jan-01, Volume: 19, Issue:1 Topics: Amides; Analgesics, Opioid; Humans; Protein Binding; Receptors, Opioid; Structure-Activity Relationship; Tramadol	2009
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Effects of naloxone and nalmefene in rat spinal cord injury induced by the ventral compression technique. Journal of spinal disorders, 1992, Volume: 5, Issue:1 Topics: Animals; Drug Evaluation, Preclinical; Intervertebral Disc Displacement; Naloxone; Naltrexone; Nerve Crush; Paralysis; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Spinal Cord Injuries; Spinal Fractures	1992
The pruritus of cholestasis and the opioid system. JAMA, 1992, Dec-16, Volume: 268, Issue:23 Topics: Cholangitis, Sclerosing; Female; Humans; Middle Aged; Naloxone; Naltrexone; Narcotic Antagonists; Pruritus; Receptors, Opioid	1992
Role of opioid antagonists in the rat liver ischemia model. Transplantation proceedings, 1991, Volume: 23, Issue:5 Topics: Animals; Calcium Channel Blockers; Hepatic Artery; Ischemia; Liver; Nalbuphine; Naloxone; Naltrexone; Narcotic Antagonists; Portal Vein; Rats; Rats, Inbred Strains; Verapamil	1991
Protective effect of nalmefene and naloxone on the ischemically damaged small bowel. Transplantation proceedings, 1991, Volume: 23, Issue:5 Topics: Animals; Intestine, Small; Ischemia; Mesenteric Arteries; Naloxone; Naltrexone; Narcotic Antagonists; Necrosis; Rats; Rats, Inbred Strains; Time Factors	1991
Naloxone antagonism of corticotropin-releasing hormone stimulation of prolactin secretion in rhesus monkeys. The Journal of clinical endocrinology and metabolism, 1989, Volume: 68, Issue:6 Topics: Animals; Corticotropin-Releasing Hormone; Dose-Response Relationship, Drug; Drug Synergism; Female; Macaca mulatta; Naloxone; Naltrexone; Narcotic Antagonists; Ovariectomy; Prolactin; Receptors, Opioid; Time Factors	1989
Pharmacological characterization of supersensitivity to naltrexone in squirrel monkeys. The Journal of pharmacology and experimental therapeutics, 1989, Volume: 250, Issue:3 Topics: Animals; Azocines; Behavior, Animal; Benzomorphans; Diprenorphine; Drug Administration Schedule; Morphine; Naloxone; Naltrexone; Receptors, Opioid; Saimiri	1989
The implication of opiates in the glucocorticoid-mediated inhibition of LH secretion in rats. The Journal of endocrinology, 1989, Volume: 122, Issue:2 Topics: Animals; Corticosterone; Dexamethasone; Luteinizing Hormone; Male; Naloxone; Naltrexone; Narcotic Antagonists; Orchiectomy; Pituitary Hormone-Releasing Hormones; Rats; Rats, Inbred Strains; Stimulation, Chemical	1989
Comparison of the duration of action of nalmefene and naloxone on the hypothalamic-pituitary axis of the rhesus monkey. Neuroendocrinology, 1989, Volume: 49, Issue:3 Topics: Animals; Female; Hypothalamo-Hypophyseal System; Luteinizing Hormone; Macaca mulatta; Naloxone; Naltrexone; Prolactin; Time Factors	1989
Opioid modulation of feeding and drinking in fowls. British poultry science, 1989, Volume: 30, Issue:2 Topics: Animals; Chickens; Drinking; Eating; Enkephalin, Methionine; Female; Injections, Intramuscular; Injections, Intravenous; Injections, Intraventricular; Naloxone; Naltrexone; Time Factors	1989
Pro-opiomelanocortin-derived peptides in the testis: evidence for a possible role in Leydig and Sertoli cell function. Medical biology, 1986, Volume: 63, Issue:5-6 Topics: Animals; beta-Endorphin; Castration; Cell Differentiation; Chromatography, High Pressure Liquid; Endorphins; Hypophysectomy; Leydig Cells; Male; Naloxone; Naltrexone; Pro-Opiomelanocortin; Progesterone; Rats; Rats, Inbred Strains; RNA, Messenger	1986
Binding of a new opiate antagonist, nalmefene, to rat brain membranes. Methods and findings in experimental and clinical pharmacology, 1985, Volume: 7, Issue:4 Topics: Animals; Binding, Competitive; Brain; In Vitro Techniques; Kinetics; Membranes; Naloxone; Naltrexone; Rats; Receptors, Opioid; Receptors, Opioid, mu	1985
Evidence for the delivery of narcotic antagonists to the colon as their glucuronide conjugates. The Journal of pharmacology and experimental therapeutics, 1988, Volume: 244, Issue:1 Topics: Animals; Colon; Constipation; Diarrhea; Dose-Response Relationship, Drug; Glucuronates; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Skin Temperature; Substance-Related Disorders	1988
Opioidergic modulation of the oestradiol-induced LH surge in the rat: roles of ovarian steroids. The Journal of endocrinology, 1988, Volume: 116, Issue:1 Topics: Animals; Diestrus; Estradiol; Female; Luteinizing Hormone; Naloxone; Naltrexone; Ovariectomy; Proestrus; Progesterone; Rats; Rats, Inbred Strains	1988
Antagonism by nalmefene of systemic and intrathecal morphine-induced analgesia in mice. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1987, Volume: 186, Issue:2 Topics: Analgesia; Animals; Injections, Intravenous; Injections, Spinal; Male; Mice; Morphine; Naloxone; Naltrexone; Time Factors	1987
Antagonism of endogenous opioids modulates memory processing. Brain research, 1987, Oct-06, Volume: 422, Issue:2 Topics: Animals; Anisomycin; Avoidance Learning; Dose-Response Relationship, Drug; Electroshock; Endorphins; Learning; Male; Memory; Mice; Naloxone; Naltrexone; Scopolamine	1987
The effects of opioid receptor antagonists suggest that testicular opiates regulate Sertoli and Leydig cell function in the neonatal rat. Endocrinology, 1986, Volume: 118, Issue:5 Topics: Androgen-Binding Protein; Animals; Animals, Newborn; Dose-Response Relationship, Drug; Endorphins; Hypertrophy; Leydig Cells; Male; Naloxone; Naltrexone; Orchiectomy; Rats; Rats, Inbred Strains; Sertoli Cells; Testis; Testosterone	1986
Investigation into the use of narcotic antagonists in the treatment of a stereotypic behavior pattern (crib-biting) in the horse. American journal of veterinary research, 1987, Volume: 48, Issue:2 Topics: Animals; Behavior, Animal; Female; Horses; Male; Naloxone; Naltrexone; Narcotic Antagonists	1987
Unexpected effects of nalmefene, a new opiate antagonist, on the hypothalamic-pituitary-gonadal axis in the male rat. Steroids, 1985, Volume: 46, Issue:6 Topics: Animals; Dose-Response Relationship, Drug; Feedback; Hypothalamo-Hypophyseal System; Luteinizing Hormone; Male; Naloxone; Naltrexone; Rats; Testosterone; Time Factors	1985
Nalmefene: radioimmunoassay for a new opioid antagonist. Journal of pharmaceutical sciences, 1984, Volume: 73, Issue:11 Topics: Humans; Kinetics; Naloxone; Naltrexone; Narcotic Antagonists; Radioimmunoassay	1984
A rapid, quantitative in vivo assay for narcotic antagonists. Substance and alcohol actions/misuse, 1984, Volume: 5, Issue:2 Topics: Animals; Dose-Response Relationship, Drug; Female; Humans; Morphine Dependence; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Skin Temperature; Tail; Time Factors	1984
Do testicular opiates regulate Leydig cell function? Endocrinology, 1984, Volume: 115, Issue:4 Topics: Androgen-Binding Protein; Animals; Chorionic Gonadotropin; Endorphins; Epididymis; Leydig Cells; Male; Naloxone; Naltrexone; Organ Size; Rats; Rats, Inbred Strains; Testosterone	1984
Nalmefene decreases meal size, food and water intake and weight gain in Zucker rats. Pharmacology, biochemistry, and behavior, 1983, Volume: 19, Issue:2 Topics: Animals; Appetite; Appetite Depressants; Body Weight; Drinking; Energy Intake; Female; Male; Naloxone; Naltrexone; Obesity; Rats; Rats, Zucker; Time Factors	1983
Nalmefene: quantitation of a new narcotic antagonist in human plasma using high performance-liquid chromatography with electrochemical detection. Research communications in chemical pathology and pharmacology, 1983, Volume: 42, Issue:3 Topics: Chromatography, High Pressure Liquid; Electrochemistry; Humans; Kinetics; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Time Factors	1983
Orally administered opioid antagonists reverse both mu and kappa opioid agonist delay of gastrointestinal transit in the guinea pig. Life sciences, 1995, Volume: 56, Issue:14 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Gastrointestinal Transit; Guinea Pigs; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid, kappa; Receptors, Opioid, mu	1995
Melatonin modifies prolactin release induced by opiate antagonists in male rats. Endocrine research, 1995, Volume: 21, Issue:3 Topics: Animals; Injections, Subcutaneous; Male; Melatonin; Naloxone; Naltrexone; Narcotic Antagonists; Prolactin; Quaternary Ammonium Compounds; Rats; Rats, Wistar	1995
Inhibiting a spinal dynorphin A component enhances intrathecal morphine antinociception in mice. Anesthesia and analgesia, 1993, Volume: 77, Issue:6 Topics: Analgesics; Animals; Cerebral Ventricles; Dynorphins; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Spine	1993
The effect of nalmefene on pulsatile secretion of luteinizing hormone and prolactin in men. Human reproduction (Oxford, England), 1993, Volume: 8, Issue:10 Topics: Adult; Endorphins; Humans; Luteinizing Hormone; Male; Naloxone; Naltrexone; Prolactin; Secretory Rate	1993
Influence of hyperkalaemia and ischaemia on non-receptor-mediated cardiac electrophysiological effects of naloxone. Cardiovascular research, 1993, Volume: 27, Issue:2 Topics: Action Potentials; Animals; Culture Techniques; Dose-Response Relationship, Drug; Electrophysiology; Heart Conduction System; Hyperkalemia; Morphine; Myocardial Ischemia; Naloxone; Naltrexone; Narcotic Antagonists; Rabbits; Refractory Period, Electrophysiological	1993
Duration of opioid antagonism by nalmefene and naloxone in the dog: an integrated pharmacokinetic/pharmacodynamic comparison. Journal of pharmaceutical sciences, 1995, Volume: 84, Issue:9 Topics: Animals; Blood Gas Monitoring, Transcutaneous; Dogs; Female; Fentanyl; Infusions, Intravenous; Models, Biological; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Respiration	1995
Duration of opioid antagonism by nalmefene and naloxone in the dog. A nonparametric pharmacodynamic comparison based on generalized cross-validated spline estimation. International journal of clinical pharmacology and therapeutics, 1995, Volume: 33, Issue:10 Topics: Analysis of Variance; Animals; Carbon Dioxide; Computer Simulation; Cross-Over Studies; Dogs; Drug Tolerance; Fentanyl; Injections, Intravenous; Male; Models, Statistical; Naloxone; Naltrexone; Narcotic Antagonists; Respiratory Insufficiency; Time Factors	1995
Effects of melatonin in vivo upon luteinizing hormone and prolactin releases induced by opiate receptor antagonists in adult male rats. Journal of endocrinological investigation, 1996, Volume: 19, Issue:2 Topics: Animals; Luteinizing Hormone; Male; Melatonin; Naloxone; Naltrexone; Narcotic Antagonists; Prolactin; Quaternary Ammonium Compounds; Rats; Rats, Wistar	1996
Nalmefene causes greater hypothalamic-pituitary-adrenal axis activation than naloxone in normal volunteers: implications for the treatment of alcoholism. Alcoholism, clinical and experimental research, 1998, Volume: 22, Issue:7 Topics: Adrenocorticotropic Hormone; Adult; Aged; Alcoholism; Female; Humans; Hydrocortisone; Hypothalamo-Hypophyseal System; Infusions, Intravenous; Male; Middle Aged; Naloxone; Naltrexone; Narcotic Antagonists; Pituitary-Adrenal System; Treatment Outcome	1998
Nalmefene. JF 1, nalmetrene, NIH 10365, ORF 11676, Arthrene, Cervene, Incystene, Revex. Drugs in R&D, 1999, Volume: 1, Issue:1 Topics: Animals; Drug Overdose; Drugs, Investigational; Humans; Male; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Rabbits; Stroke	1999
Inhibition of passive cutaneous anaphylaxis-associated scratching behavior by mu-opioid receptor antagonists in ICR mice. International archives of allergy and immunology, 2000, Volume: 123, Issue:4 Topics: Animals; Behavior, Animal; Capillary Permeability; Female; Histamine; Humans; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Narcotic Antagonists; p-Methoxy-N-methylphenethylamine; Passive Cutaneous Anaphylaxis; Pruritus; Receptors, Opioid, mu	2000
Inverse agonists and neutral antagonists at mu opioid receptor (MOR): possible role of basal receptor signaling in narcotic dependence. Journal of neurochemistry, 2001, Volume: 77, Issue:6 Topics: Analgesics, Opioid; Animals; Benzylidene Compounds; Cell Line; Cell Membrane; Cyclic AMP; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Kidney; Magnesium; Male; Mice; Mice, Inbred ICR; Morphine; Morphine Dependence; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Receptors, Opioid, mu; Signal Transduction; Substance Withdrawal Syndrome; Sulfur Radioisotopes; Transfection; Tritium	2001
The opioid receptor pharmacology of GSK1521498 compared to other ligands with differential effects on compulsive reward-related behaviours. Psychopharmacology, 2015, Volume: 232, Issue:1 Topics: Analgesics, Opioid; Animals; CHO Cells; Compulsive Behavior; Cricetinae; Cricetulus; Guanosine 5'-O-(3-Thiotriphosphate); HEK293 Cells; Humans; Indans; Ligands; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Protein Binding; Receptors, Opioid, mu; Reward; Treatment Outcome; Triazoles	2015
Nalmefene Prevents Alcohol-Induced Neuroinflammation and Alcohol Drinking Preference in Adolescent Female Mice: Role of TLR4. Alcoholism, clinical and experimental research, 2017, Volume: 41, Issue:7 Topics: Alcohol Drinking; Alcohol-Related Disorders; Animals; Astrocytes; Cell Death; Chemokines; Drug Evaluation, Preclinical; Ethanol; Female; Membrane Microdomains; Mice, Inbred C57BL; Mice, Knockout; Myelin Sheath; Naloxone; Naltrexone; Narcotic Antagonists; Primary Cell Culture; Toll-Like Receptor 4	2017
Nalmefene nasal spray (Opvee) for reversal of opioid overdose. The Medical letter on drugs and therapeutics, 2023, 10-16, Volume: 65, Issue:1687 Topics: Analgesics, Opioid; Drug Overdose; Humans; Naloxone; Naltrexone; Narcotic Antagonists; Nasal Sprays; Opiate Overdose	2023