nalmefene and morphine

nalmefene has been researched along with morphine in 32 studies

Research

Studies (32)

Timeframe	Studies, this research(%)	All Research%
pre-1990	6 (18.75)	18.7374
1990's	10 (31.25)	18.2507
2000's	9 (28.13)	29.6817
2010's	5 (15.63)	24.3611
2020's	2 (6.25)	2.80

Authors

Authors	Studies
Adapa, ID; Auh, JS; Berzetei-Gurske, IP; Brandt, SR; Craymer, K; Farrington, L; Haggart, D; Kennedy, JM; O'Brien, A; Polgar, WE; Rodriguez, L; Schwartz, RW; Toll, L; White, A	1
Strassburg, CP; Tukey, RH	1
Lombardo, F; Obach, RS; Waters, NJ	1
Bidlack, JM; Bu, Y; Cohen, DJ; Lou, R; Lu, Q; VanAlstine, MA; Wentland, MP	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Millard, WJ; Simpkins, JW; Swager, D	1
Allen, JT; Brostrom, PA; DeHaven-Hudkins, DL; Ferkany, JW; Kaplita, PV; Lesko, LJ; Mavunkel, BJ; Rzeszotarski, WJ; Steranka, LR	1
Fudala, PJ; Heishman, SJ; Henningfield, JE; Johnson, RE	1
France, CP; Morse, WH	1
Flood, JF; Morley, JE	1
Altman, DG; Barrowcliffe, MP; Jones, JG; Jordan, C; Konieczko, KM	1
Dixon, R; Simpkins, JW; Smulkowski, M; Tuttle, R	1
Billington, CJ; Brown, DM; Gosnell, BA; Grace, M; Krahn, DD; Levine, AS; Morley, JE	1
Arteau, C; Fujimoto, JM; Roerig, SC	1
Culpepper-Morgan, JA; Holt, PR; Kreek, MJ; LaRoche, D	1
Fujimoto, JM; Holmes, BB	1
Cobbe, SM; Hicks, MN; Oldroyd, KG	1
Henderson, CA; Reynolds, JE	1
Hernandez, AV; Norton, JA; Storrow, AB	1
Chehade, J; Duffy, L; Gajraj, N; Johnson, ER; Joshi, GP; Wesevich, J	1
Ko, MC; Naughton, NN	1
Fudala, PJ; Heishman, SJ; Henningfield, JE; Johnson, RE; Jones, HE	1
Bilsky, EJ; Raehal, KM; Sadée, W; Wang, D	1
Bailey, SL; Faut-Callahan, M; Graves, J; Paice, JA; Pellegrini, JE; Shott, S	1
Ko, MC; Lee, H; Naughton, NN; Woods, JH	1
Bilsky, EJ; Giuvelis, D; Lowery, JJ; Osborn, MD; Skorput, AG	1
Diatchenko, L; Ding, F; Dokholyan, NV; Gauthier, J; Gibson, DG; Maixner, W; Serohijos, AW; Yin, S	1
Bullmore, ET; Felici, A; Henderson, G; Kelly, E; Maltby, K; Mundell, SJ; Nathan, PJ; Roth, AL; Sava, A	1
Kreek, MJ; Reed, B; Windisch, KA	1
An, J; Chen, C; Li, X; Lu, H; Tan, R; Wang, F; Wang, J; Wu, G; Zhao, X	1
Kunzler, NM; Nelson, LS; Wightman, RS	1
Cang, J; Chen, J; Fang, F; Huang, J; Jiang, M; Li, A; Li, G; Li, J; Li, W; Luo, J; Yan, H	1

Reviews

2 review(s) available for nalmefene and morphine

Article	Year
Human UDP-glucuronosyltransferases: metabolism, expression, and disease. Annual review of pharmacology and toxicology, 2000, Volume: 40 Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic	2000
Opioid Withdrawal Precipitated by Long-Acting Antagonists. The Journal of emergency medicine, 2020, Volume: 58, Issue:2 Topics: Drug Combinations; Emergency Service, Hospital; Humans; Morphine; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Substance Withdrawal Syndrome	2020

Trials

6 trial(s) available for nalmefene and morphine

Article	Year
Human pharmacology and abuse potential of nalmefene. Clinical pharmacology and therapeutics, 1991, Volume: 49, Issue:3 Topics: Adult; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Male; Morphine; Naltrexone; Narcotic Antagonists; Substance-Related Disorders	1991
Antagonism of morphine-induced respiratory depression with nalmefene. British journal of anaesthesia, 1988, Volume: 61, Issue:3 Topics: Adult; Carbon Dioxide; Depression, Chemical; Humans; Male; Middle Aged; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Partial Pressure; Respiration; Time Factors	1988
Effects of prophylactic nalmefene on the incidence of morphine-related side effects in patients receiving intravenous patient-controlled analgesia. Anesthesiology, 1999, Volume: 90, Issue:4 Topics: Adult; Analgesia, Patient-Controlled; Analgesics, Opioid; Dose-Response Relationship, Drug; Female; Humans; Middle Aged; Morphine; Naltrexone; Narcotic Antagonists; Nausea; Postoperative Complications; Pruritus; Vomiting	1999
Nalmefene: blockade of intravenous morphine challenge effects in opioid abusing humans. Drug and alcohol dependence, 2000, Jul-01, Volume: 60, Issue:1 Topics: Adult; Analysis of Variance; Cross-Over Studies; Double-Blind Method; Humans; Injections, Intravenous; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Pupil	2000
The impact of nalmefene on side effects due to intrathecal morphine at cesarean section. AANA journal, 2001, Volume: 69, Issue:3 Topics: Adult; Analgesia, Epidural; Analgesics, Opioid; Cesarean Section; Double-Blind Method; Female; Humans; Morphine; Naltrexone; Narcotic Antagonists; Pain, Postoperative; Postoperative Complications; Postoperative Nausea and Vomiting; Pregnancy; Pruritus; Statistics, Nonparametric; Survival Analysis; Time Factors	2001
Prophylatic use of IV nalmefene to prevent epidural opioid-induced pruritus: A multicenter, randomized clinical trial. Journal of clinical anesthesia, 2024, Volume: 92 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesia, Epidural; Analgesics, Opioid; Double-Blind Method; Humans; Middle Aged; Morphine; Pain, Postoperative; Pruritus; Young Adult	2024

Other Studies

24 other study(ies) available for nalmefene and morphine

Article	Year
Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications. NIDA research monograph, 1998, Volume: 178 Topics: Animals; Aorta, Thoracic; Cocaine; Cyclic AMP; Electric Stimulation; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Mice; Muscle, Smooth; Opioid-Related Disorders; Rats; Receptors, Dopamine; Receptors, Opioid; Receptors, Serotonin; Substance-Related Disorders	1998
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Syntheses and opioid receptor binding properties of carboxamido-substituted opioids. Bioorganic & medicinal chemistry letters, 2009, Jan-01, Volume: 19, Issue:1 Topics: Amides; Analgesics, Opioid; Humans; Protein Binding; Receptors, Opioid; Structure-Activity Relationship; Tramadol	2009
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Evaluation of the sites of opioid influence on anterior pituitary hormone secretion using a quaternary opiate antagonist. Neuroendocrinology, 1991, Volume: 54, Issue:4 Topics: Analgesia; Animals; Brain Mapping; Male; Morphine; Naltrexone; Narcotic Antagonists; Neurons; Pain Measurement; Pituitary Hormones, Anterior; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu	1991
Pharmacologic profile of NPC 168 (naltrexone phenyl oxime), a novel compound with activity at opioid receptors. Pharmacology, biochemistry, and behavior, 1990, Volume: 37, Issue:3 Topics: Animals; Binding, Competitive; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Food Deprivation; Guinea Pigs; Injections, Intraventricular; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Reaction Time; Reinforcement Schedule	1990
Pharmacological characterization of supersensitivity to naltrexone in squirrel monkeys. The Journal of pharmacology and experimental therapeutics, 1989, Volume: 250, Issue:3 Topics: Animals; Azocines; Behavior, Animal; Benzomorphans; Diprenorphine; Drug Administration Schedule; Morphine; Naloxone; Naltrexone; Receptors, Opioid; Saimiri	1989
An investigation of tolerance to the actions of leptogenic and anorexigenic drugs in mice. Life sciences, 1987, Nov-02, Volume: 41, Issue:18 Topics: Amphetamine; Animals; Appetite Depressants; Body Weight; Calcitonin; Dextroamphetamine; Drug Tolerance; Eating; Fluoxetine; Mice; Morphine; Naltrexone; Neurotransmitter Agents	1987
Evidence for the delivery of narcotic antagonists to the colon as their glucuronide conjugates. The Journal of pharmacology and experimental therapeutics, 1988, Volume: 244, Issue:1 Topics: Animals; Colon; Constipation; Diarrhea; Dose-Response Relationship, Drug; Glucuronates; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Skin Temperature; Substance-Related Disorders	1988
Effect of morphine and nalmefene on energy balance in diabetic and non-diabetic rats. Pharmacology, biochemistry, and behavior, 1988, Volume: 29, Issue:3 Topics: Animals; Body Weight; Diabetes Mellitus, Experimental; Eating; Energy Metabolism; Male; Morphine; Naltrexone; Rats; Rats, Inbred Strains	1988
Antagonism by nalmefene of systemic and intrathecal morphine-induced analgesia in mice. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1987, Volume: 186, Issue:2 Topics: Analgesia; Animals; Injections, Intravenous; Injections, Spinal; Male; Mice; Morphine; Naloxone; Naltrexone; Time Factors	1987
Orally administered opioid antagonists reverse both mu and kappa opioid agonist delay of gastrointestinal transit in the guinea pig. Life sciences, 1995, Volume: 56, Issue:14 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Gastrointestinal Transit; Guinea Pigs; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid, kappa; Receptors, Opioid, mu	1995
Inhibiting a spinal dynorphin A component enhances intrathecal morphine antinociception in mice. Anesthesia and analgesia, 1993, Volume: 77, Issue:6 Topics: Analgesics; Animals; Cerebral Ventricles; Dynorphins; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Spine	1993
Influence of hyperkalaemia and ischaemia on non-receptor-mediated cardiac electrophysiological effects of naloxone. Cardiovascular research, 1993, Volume: 27, Issue:2 Topics: Action Potentials; Animals; Culture Techniques; Dose-Response Relationship, Drug; Electrophysiology; Heart Conduction System; Hyperkalemia; Morphine; Myocardial Ischemia; Naloxone; Naltrexone; Narcotic Antagonists; Rabbits; Refractory Period, Electrophysiological	1993
Acute pulmonary edema in a young male after intravenous nalmefene. Anesthesia and analgesia, 1997, Volume: 84, Issue:1 Topics: Acute Disease; Adult; Analgesics, Opioid; Anesthesia; Humans; Infusions, Intravenous; Male; Morphine; Naltrexone; Narcotic Antagonists; Pulmonary Edema	1997
Nalmefene and the urine opiate screen. Clinical chemistry, 1998, Volume: 44, Issue:2 Topics: Adult; Cross Reactions; Drug Evaluation, Preclinical; False Positive Reactions; Humans; Immunoassay; Molecular Structure; Morphine; Naltrexone; Narcotics	1998
An experimental itch model in monkeys: characterization of intrathecal morphine-induced scratching and antinociception. Anesthesiology, 2000, Volume: 92, Issue:3 Topics: Analgesics, Opioid; Animals; Antipruritics; Dose-Response Relationship, Drug; Female; Hot Temperature; Injections, Spinal; Macaca mulatta; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Pruritus; Receptors, Opioid	2000
Inverse agonists and neutral antagonists at mu opioid receptor (MOR): possible role of basal receptor signaling in narcotic dependence. Journal of neurochemistry, 2001, Volume: 77, Issue:6 Topics: Analgesics, Opioid; Animals; Benzylidene Compounds; Cell Line; Cell Membrane; Cyclic AMP; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Kidney; Magnesium; Male; Mice; Mice, Inbred ICR; Morphine; Morphine Dependence; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Receptors, Opioid, mu; Signal Transduction; Substance Withdrawal Syndrome; Sulfur Radioisotopes; Transfection; Tritium	2001
Characterization of scratching responses in rats following centrally administered morphine or bombesin. Behavioural pharmacology, 2003, Volume: 14, Issue:7 Topics: Analgesics, Opioid; Animals; Antipruritics; Bombesin; Brain; Dose-Response Relationship, Drug; Grooming; Injections, Intraventricular; Injections, Spinal; Male; Morphine; Naltrexone; Narcotic Antagonists; Premedication; Rats; Rats, Wistar; Receptors, Opioid, mu; Spinal Cord; Stereotyped Behavior	2003
In vivo characterization of the opioid antagonist nalmefene in mice. Life sciences, 2010, Apr-10, Volume: 86, Issue:15-16 Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Inhibitory Concentration 50; Male; Mice; Mice, Inbred ICR; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Pain; Substance Withdrawal Syndrome; Time Factors	2010
Structural basis for μ-opioid receptor binding and activation. Structure (London, England : 1993), 2011, Nov-09, Volume: 19, Issue:11 Topics: Amino Acid Substitution; Animals; Binding Sites; Binding, Competitive; Cattle; Cyclic AMP; Databases, Factual; Decapodiformes; Diprenorphine; Dose-Response Relationship, Drug; HEK293 Cells; Humans; Molecular Dynamics Simulation; Morphine; Mutagenesis, Site-Directed; Naltrexone; Protein Binding; Radioligand Assay; Receptors, Opioid, mu; Small Molecule Libraries	2011
The opioid receptor pharmacology of GSK1521498 compared to other ligands with differential effects on compulsive reward-related behaviours. Psychopharmacology, 2015, Volume: 232, Issue:1 Topics: Analgesics, Opioid; Animals; CHO Cells; Compulsive Behavior; Cricetinae; Cricetulus; Guanosine 5'-O-(3-Thiotriphosphate); HEK293 Cells; Humans; Indans; Ligands; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Protein Binding; Receptors, Opioid, mu; Reward; Treatment Outcome; Triazoles	2015
Naltrexone and nalmefene attenuate cocaine place preference in male mice. Neuropharmacology, 2018, 09-15, Volume: 140 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics, Opioid; Animals; Cocaine; Conditioning, Psychological; Dose-Response Relationship, Drug; Locomotion; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists	2018
Short term exposure to oxycodone alters the survival, proliferation and differentiation of rat embryonic neural stem cell in vitro. Brain research bulletin, 2018, Volume: 143 Topics: Analgesics, Opioid; Animals; Apoptosis; Cell Differentiation; Cell Proliferation; Cell Survival; Embryonic Stem Cells; Female; Morphine; Naltrexone; Neural Stem Cells; Oxycodone; Pregnancy; Rats; Rats, Sprague-Dawley	2018

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