Page last updated: 2024-08-22

nafenopin and phenobarbital

nafenopin has been researched along with phenobarbital in 29 studies

Research

Studies (29)

TimeframeStudies, this research(%)All Research%
pre-199013 (44.83)18.7374
1990's13 (44.83)18.2507
2000's3 (10.34)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bjondahl, K1
Keulemans, K; Meijer, DK; Vonk, RJ; Weitering, JG1
Dirven, HA; Jongeneelen, FJ; Noordhoek, J; Peters, JG; van den Broek, PH1
Bursch, W; Gerbracht, U; Kraus, P; Putz, B; Reinacher, M; Schulte-Hermann, R; Timmermann-Trosiener, I1
Erber, E; Parzefall, W; Schulte-Hermann, R; Sedivy, R1
Gerbracht, U; Huber, W; Kraupp-Grasl, B; Putz, B; Schulte-Hermann, R1
Huber, W; Kraupp-Grasl, B; Schulte-Hermann, R; Taper, H1
Préat, V; Roberfroid, M1
Bursch, W; Gerbracht, U; Kraupp-Grasl, B; Schulte-Hermann, R; Timmermann-Trosiener, I1
Furukawa, K; Furukawa, NT; Furuya, K; Numoto, S; Williams, GM1
de Gerlache, J; Lans, M; Préat, V; Roberfroid, M; Taper, H2
Bentley, P; Bieri, F; Muakkassah-Kelly, SF; Stäubli, W; Waechter, F1
Furuya, K; Levine, WG; Mori, H; Numoto, S; Williams, GM1
Dalton, C; Hope, HR; Hope, WC; Sheppard, H1
Bentley, P; Bieri, F; Fröhlich, E; Stäubli, W; Waechter, F1
Ohde, G; Schulte-Hermann, R; Schuppler, J; Timmermann-Trosiener, I1
Andreis, PG; Armato, U; Romano, F1
Arch, JR; Cawthorne, MA; Green, A1
Oberhammer, FA; Qin, HM1
Delzenne, NM; Roberfroid, M; Taper, HS1
Grasl-Kraupp, B; Huber, W; Schulte-Hermann, R; Waldhör, T1
James, NH; Roberts, RA1
Mori, H; Okumura, A; Tanaka, T1
Garberg, P; Grasl-Kraupp, B; Högberg, J; Thullberg, M1
Cattley, RC; Christensen, JG; Goldsworthy, TL; Gonzales, AJ1
Gonzalez, FJ; Hasmall, SC; James, NH; Macdonald, N; Peters, JM; Roberts, RA1
Chabicovsky, M; Grasl-Kraupp, B; Peter, B; Rossmanith, W; Schausberger, E; Schulte-Hermann, R1
Bursch, W; Hufnagl, K; Schulte-Hermann, R; Wastl, U1

Other Studies

29 other study(ies) available for nafenopin and phenobarbital

ArticleYear
A study on cerium-induced liver injury in rats after pretreatment with spironolactone, phenobarbital, pregnenolone-16 alpha-carbonitrile and nafenopin.
    Arzneimittel-Forschung, 1978, Volume: 28, Issue:5

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Cerium; Chemical and Drug Induced Liver Injury; Female; Nafenopin; Phenobarbital; Pregnenolone Carbonitrile; Propionates; Rats; Spironolactone; Time Factors; Triglycerides

1978
Hepatic uptake and biliary excretion of dibromosulphthalein. Albumin dependence, influence of phenobarbital and nafenopin pretreatment and the role of y and z protein.
    The Journal of pharmacology and experimental therapeutics, 1977, Volume: 202, Issue:1

    Topics: Animals; Bile; Carrier Proteins; Cytosol; Glutathione Transferase; In Vitro Techniques; Kinetics; Liver; Male; Models, Biological; Nafenopin; Perfusion; Phenobarbital; Propionates; Protein Binding; Rats; Serum Albumin; Serum Albumin, Bovine; Sulfobromophthalein

1977
Microsomal lauric acid hydroxylase activities after treatment of rats with three classical cytochrome P450 inducers and peroxisome proliferating compounds.
    Biochemical pharmacology, 1992, Jun-23, Volume: 43, Issue:12

    Topics: Adipates; Animals; Aroclors; Body Weight; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Diethylhexyl Phthalate; Dose-Response Relationship, Drug; Enzyme Induction; Male; Methylcholanthrene; Microbodies; Microsomes, Liver; Mixed Function Oxygenases; Nafenopin; Organ Size; Oxidoreductases; Phenobarbital; Rats; Rats, Inbred Strains

1992
Effects of hypolipidemic drugs nafenopin and clofibrate on phenotypic expression and cell death (apoptosis) in altered foci of rat liver.
    Carcinogenesis, 1990, Volume: 11, Issue:4

    Topics: Animals; Body Weight; Carcinogens; Cell Survival; Clofibrate; Cyproterone; Cyproterone Acetate; Female; Glutathione Transferase; Hexachlorocyclohexane; Liver; Liver Neoplasms, Experimental; Nafenopin; Nitrosamines; Organ Size; Phenobarbital; Phenotype; Precancerous Conditions; Propionates; Rats; Rats, Inbred Strains

1990
Testing for induction of DNA synthesis in human hepatocyte primary cultures by rat liver tumor promoters.
    Cancer research, 1991, Feb-15, Volume: 51, Issue:4

    Topics: Adult; Aged; Autoradiography; Carcinogens; Cyproterone; Cyproterone Acetate; DNA; Dose-Response Relationship, Drug; Epidermal Growth Factor; Female; Gene Expression Regulation; Hexachlorocyclohexane; Humans; In Vitro Techniques; Liver; Male; Middle Aged; Nafenopin; Phenobarbital; Recombinant Proteins; Rifampin

1991
Tumor promotion by the peroxisome proliferator nafenopin involving a specific subtype of altered foci in rat liver.
    Cancer research, 1990, Jun-15, Volume: 50, Issue:12

    Topics: Aflatoxin B1; Aflatoxins; Animals; Body Weight; Carcinoma; Female; gamma-Glutamyltransferase; Liver; Liver Neoplasms, Experimental; Male; Nafenopin; Phenobarbital; Propionates; Rats; Rats, Inbred Strains; Time Factors

1990
Increased susceptibility of aged rats to hepatocarcinogenesis by the peroxisome proliferator nafenopin and the possible involvement of altered liver foci occurring spontaneously.
    Cancer research, 1991, Jan-15, Volume: 51, Issue:2

    Topics: Aging; Animals; Liver; Liver Neoplasms, Experimental; Male; Microbodies; Nafenopin; Phenobarbital; Precancerous Conditions; Rats; Rats, Inbred Strains; Reference Values

1991
Modulation of neoplastic development: concepts and examples.
    Bulletin du cancer, 1990, Volume: 77, Issue:5

    Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Diet; Enzyme Induction; Hepatectomy; Liver Neoplasms, Experimental; Mice; Models, Biological; Nafenopin; Neoplasms, Experimental; Phenobarbital; Portacaval Shunt, Surgical; Rats; Xenobiotics

1990
Effects of non-genotoxic hepatocarcinogens phenobarbital and nafenopin on phenotype and growth of different populations of altered foci in rat liver.
    Toxicologic pathology, 1989, Volume: 17, Issue:4 Pt 1

    Topics: Aging; Animals; Carcinogenicity Tests; Carcinogens; Cell Survival; Female; gamma-Glutamyltransferase; Liver; Liver Neoplasms, Experimental; Microbodies; Nafenopin; Phenobarbital; Phenotype; Propionates; Rats

1989
Effects of the hepatocarcinogen nafenopin, a peroxisome proliferator, on the activities of rat liver glutathione-requiring enzymes and catalase in comparison to the action of phenobarbital.
    Cancer research, 1985, Volume: 45, Issue:10

    Topics: Animals; Body Weight; Catalase; gamma-Glutamyltransferase; Glutathione Peroxidase; Glutathione Transferase; In Vitro Techniques; Kinetics; Liver; Liver Neoplasms; Male; Microbodies; Nafenopin; Organ Size; Phenobarbital; Propionates; Rats; Rats, Inbred F344

1985
Comparative analysis of the effect of phenobarbital, dichlorodiphenyltrichloroethane, butylated hydroxytoluene and nafenopin on rat hepatocarcinogenesis.
    Carcinogenesis, 1986, Volume: 7, Issue:6

    Topics: Animals; Butylated Hydroxytoluene; Cocarcinogenesis; DDT; gamma-Glutamyltransferase; Liver Neoplasms, Experimental; Nafenopin; Phenobarbital; Precancerous Conditions; Rats

1986
Comparison of the biological effects of phenobarbital and nafenopin on rat hepatocarcinogenesis.
    Japanese journal of cancer research : Gann, 1986, Volume: 77, Issue:7

    Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; gamma-Glutamyltransferase; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Nafenopin; Phenobarbital; Propionates; Rats; Rats, Inbred Strains

1986
Long-term maintenance of hepatocytes in primary culture in the presence of DMSO: further characterization and effect of nafenopin, a peroxisome proliferator.
    Experimental cell research, 1987, Volume: 171, Issue:1

    Topics: Animals; Cells, Cultured; Culture Media; Cytochrome P-450 Enzyme System; Dimethyl Sulfoxide; DNA; Endoplasmic Reticulum; Enzyme Induction; Liver; Male; Methylcholanthrene; Microbodies; Microscopy, Electron; Nafenopin; Oxidoreductases; Palmitoyl Coenzyme A; Phenobarbital; Propionates; Rats; Rats, Inbred Strains

1987
Absence of a promoting or sequential syncarcinogenic effect in rat liver by the carcinogenic hypolipidemic drug nafenopin given after N-2-fluorenylacetamide.
    Toxicology and applied pharmacology, 1985, Volume: 77, Issue:1

    Topics: 2-Acetylaminofluorene; Administration, Oral; Animals; Body Weight; Carcinogens; Drug Synergism; Liver Neoplasms; Male; Nafenopin; Neoplasms, Experimental; Phenobarbital; Propionates; Rats; Rats, Inbred F344

1985
Relationship of serum triglyceride lowering to changes in hepatic composition induced by different classes of drugs.
    Biochemical pharmacology, 1974, Feb-01, Volume: 23, Issue:3

    Topics: Animals; Cholesterol; Clofibrate; Dactinomycin; DNA; Dose-Response Relationship, Drug; Glycolates; Hepatomegaly; Hypolipidemic Agents; In Vitro Techniques; Liver; Male; Microsomes, Liver; Mitochondria, Liver; Nafenopin; Oxidoreductases, N-Demethylating; Phenobarbital; Phenyl Ethers; Phenytoin; Phospholipids; Piperazines; Piperidines; Propionates; Proteins; Rats; RNA; Spectrophotometry, Ultraviolet; Triglycerides

1974
Inhibitory effect of nafenopin upon the development of diethylnitrosamine-induced enzyme-altered foci within the rat liver.
    Carcinogenesis, 1984, Volume: 5, Issue:1

    Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Epoxide Hydrolases; gamma-Glutamyltransferase; Liver; Nafenopin; Nitrosamines; Organ Size; Phenobarbital; Propionates; Rats

1984
Enhanced proliferation of putative preneoplastic cells in rat liver following treatment with the tumor promoters phenobarbital, hexachlorocyclohexane, steroid compounds, and nafenopin.
    Cancer research, 1981, Volume: 41, Issue:6

    Topics: Animals; Autoradiography; Cell Division; Cocarcinogenesis; DNA; Female; gamma-Glutamyltransferase; Hexachlorocyclohexane; Liver Neoplasms; Mitogens; Nafenopin; Neoplasms, Experimental; Phenobarbital; Precancerous Conditions; Rats

1981
The tumor promoters TPA, phenobarbital, and nafenopin and the prostaglandins of A, E, and F series overcome the G1/S block imposed by extracellular calcium deprivation on neonatal rat hepatocytes.
    Prostaglandins, leukotrienes, and medicine, 1984, Volume: 13, Issue:3

    Topics: Animals; Calcium; Carcinogens; Cell Cycle; Cells, Cultured; DNA Replication; Female; Hormones; Imidazoles; Indomethacin; Liver; Male; Nafenopin; Phenobarbital; Prostaglandins; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate

1984
Effects of nafenopin, diphenylhydantoin, phenobarbitone and some acetylenes on body composition: is there a relationship between decreased carcass lipid and increased liver size and induction of drug metabolizing enzymes?
    International journal of obesity, 1980, Volume: 4, Issue:1

    Topics: Acetylene; Alkynes; Animals; Body Composition; Chemical Phenomena; Chemistry; Eating; Lipid Metabolism; Liver; Mice; Mice, Obese; Nafenopin; Organ Size; Oxygen Consumption; Phenobarbital; Phenytoin; Propionates

1980
Effect of three tumour promoters on the stability of hepatocyte cultures and apoptosis after transforming growth factor-beta 1.
    Carcinogenesis, 1995, Volume: 16, Issue:6

    Topics: Apoptosis; Carcinogens; Cell Differentiation; Cells, Cultured; Cyproterone Acetate; Epidermal Growth Factor; In Vitro Techniques; Liver; Nafenopin; Phenobarbital; Proliferating Cell Nuclear Antigen; Time Factors; Transforming Growth Factor beta

1995
Modifications of liver bile acids pool during modulation of rat hepatocarcinogenesis by phenobarbital and nafenopin.
    Archives of toxicology, 1994, Volume: 68, Issue:6

    Topics: Animals; Bile Acids and Salts; Liver; Liver Neoplasms, Experimental; Male; Nafenopin; Phenobarbital; Rats; Rats, Wistar

1994
Glutathione S-transferase isoenzyme patterns in different subtypes of enzyme-altered rat liver foci treated with the peroxisome proliferator nafenopin or with phenobarbital.
    Carcinogenesis, 1993, Volume: 14, Issue:11

    Topics: Adenoma; Aflatoxin B1; Animals; Carcinogens; Female; Glutathione Transferase; Isoenzymes; Liver; Liver Neoplasms, Experimental; Macromolecular Substances; Male; Microbodies; Nafenopin; Phenobarbital; Rats; Rats, Wistar

1993
Species differences in response to peroxisome proliferators correlate in vitro with induction of DNA synthesis rather than suppression of apoptosis.
    Carcinogenesis, 1996, Volume: 17, Issue:8

    Topics: Animals; Apoptosis; Blood; Clofenapate; Cricetinae; Culture Media; DNA Damage; DNA Replication; Dogs; Guinea Pigs; Homeostasis; Male; Mice; Microbodies; Nafenopin; Phenobarbital; Pyrimidines; Rats; Species Specificity; Transforming Growth Factors

1996
Simultaneous measurement of unscheduled and replicating DNA synthesis by means of a new cell culture insert DNA retention method: rapid induction of replicating DNA synthesis in response to genotoxic carcinogens.
    Japanese journal of cancer research : Gann, 1996, Volume: 87, Issue:8

    Topics: 2-Acetylaminofluorene; Aminobiphenyl Compounds; Animals; Autoradiography; Carcinogens; Cells, Cultured; Diethylnitrosamine; DNA; DNA Replication; Hydroxyurea; Liver; Male; Mutagens; Nafenopin; Phenobarbital; Rats; Scintillation Counting

1996
Changes in liver fatty acid-binding protein in rat enzyme-altered foci.
    Cancer letters, 1998, Jun-05, Volume: 128, Issue:1

    Topics: Animals; Antibody Specificity; Carcinogens; Carrier Proteins; Diethylnitrosamine; Fatty Acid-Binding Protein 7; Fatty Acid-Binding Proteins; Female; Hepatectomy; Immune Sera; Liver; Myelin P2 Protein; Nafenopin; Neoplasm Proteins; Nerve Tissue Proteins; Phenobarbital; Polychlorinated Biphenyls; Rats; Rats, Sprague-Dawley

1998
Regulation of apoptosis in mouse hepatocytes and alteration of apoptosis by nongenotoxic carcinogens.
    Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, 1998, Volume: 9, Issue:9

    Topics: Animals; Anti-Bacterial Agents; Apoptosis; Bleomycin; Carcinogens; Cells, Cultured; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Nafenopin; Phenobarbital; Proto-Oncogene Proteins c-bcl-2; Receptors, Cytoplasmic and Nuclear; Transcription Factors; Transforming Growth Factor beta; Tumor Suppressor Protein p53

1998
Suppression of mouse hepatocyte apoptosis by peroxisome proliferators: role of PPARalpha and TNFalpha.
    Mutation research, 2000, Mar-17, Volume: 448, Issue:2

    Topics: Animals; Apoptosis; DNA; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nafenopin; Oxidation-Reduction; Peroxisome Proliferators; Peroxisomes; Phenobarbital; Receptors, Cytoplasmic and Nuclear; Transcription Factors; Tumor Necrosis Factor-alpha

2000
Follistatin overexpression in rodent liver tumors: a possible mechanism to overcome activin growth control.
    Molecular carcinogenesis, 2002, Volume: 35, Issue:1

    Topics: Activins; Adenoma; Alternative Splicing; Animals; Blotting, Western; Carcinoma, Hepatocellular; Cell Division; Diethylnitrosamine; Follistatin; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Male; Mice; Mice, Inbred Strains; Nafenopin; Phenobarbital; Rats; Reference Values; RNA, Messenger; Transforming Growth Factor alpha; Tumor Cells, Cultured

2002
No increase of apoptosis in regressing mouse liver after withdrawal of growth stimuli or food restriction.
    Toxicological sciences : an official journal of the Society of Toxicology, 2005, Volume: 85, Issue:1

    Topics: Animals; Apoptosis; DNA; Female; Food Deprivation; Hepatomegaly; Liver; Male; Mice; Mice, Inbred Strains; Nafenopin; Organ Size; Phenobarbital; Protein Biosynthesis; Species Specificity

2005