Page last updated: 2024-08-17

nad and triclosan

nad has been researched along with triclosan in 30 studies

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (13.33)18.2507
2000's16 (53.33)29.6817
2010's9 (30.00)24.3611
2020's1 (3.33)2.80

Authors

AuthorsStudies
Heath, RJ; Holland, DR; Rock, CO; Rubin, JR; Snow, ME; Zhang, E1
Kisker, C; Parikh, S; Stewart, MJ; Tonge, PJ; Xiao, G1
Britton, CJ; Camble, R; Clayton, E; Colls, JG; Hales, NJ; Holdgate, GA; Jude, DA; McLean, EG; Minshull, CA; Mistry, A; Nichols, WW; Pauptit, RA; Rowsell, S; Taylor, IW; Timms, D; Ward, WH1
Abdel-Meguid, SS; Court, RI; Janson, CA; Payne, DJ; Qiu, X; Smyth, MG1
Surolia, A; Surolia, N1
Suguna, K; Surolia, A; Surolia, N1
Copeland, RA; Jiang, W; Kopcho, LM; Locke, G; Luo, Y; Marcinkeviciene, J1
Baldock, C; Clough, JM; Levy, CW; Rafferty, JB; Rice, DW; Sedelnikova, S; Slabas, AR; Stuitje, AR; Viner, RC; Wallace, AJ1
Dar, MJ; Kapoor, M; Surolia, A; Surolia, N1
Cho, YH; Kim, EJ; Lee, IH; Lee, JK1
Muralidharan, J; Suguna, K; Surolia, A; Surolia, N1
McLeod, R; Muench, SP; Prigge, ST; Rafferty, JB; Rice, DW1
Cui, G; Johnson, F; Novichenok, P; Simmerling, C; Sivaraman, S; Sullivan, TJ; Tonge, PJ1
Kapoor, M; Mukhi, PL; Suguna, K; Surolia, A; Surolia, N1
Gopalakrishnapai, J; Kapoor, M; Surolia, A; Surolia, N1
Kapoor, M; Pidugu, LS; Suguna, K; Surolia, A; Surolia, N1
Kirisits, MJ; McLeod, R; Muench, SP; Prigge, ST; Rice, DW; Roberts, CW; Wernimont, S; Zhu, L1
Cheng, X; Cui, G; Rafi, SB; Simmerling, C; Song, K; Tonge, PJ1
Kirisits, MJ; McLeod, R; Muench, SP; Mui, EJ; Prigge, ST; Rafferty, JB; Rice, DW; Roberts, CW1
Cai, J; Cai, X; Lorraine Fuller, A; McDougald, LR; Sacchettini, JC; Tan, X; Wang, F; Zhu, G1
Lu, H; Tonge, PJ1
Chen, YD; Lu, XY; You, QD1
Johnson, ME; Mehboob, S; Santarsiero, BD; Truong, K1
Chi, YM; Lee, JH; Lee, KS; Moon, JH; Park, AK1
Lindert, S; McCammon, JA1
Guardado-Calvo, P; Llamas-Saiz, AL; Noël, AJ; Otero, JM; Pingoud, A; Schierling, B; van Raaij, MJ; Wende, W1
Afanador, GA; Anderson, JW; Cheng, G; Fidock, DA; Fishwick, CW; Fomovska, A; Freire, E; Freundlich, JS; Jacobus, DP; Kozikowski, AP; McLeod, R; McPhillie, M; Muench, SP; Prigge, ST; Rice, DW; Schön, A; Shieh, HM; Stec, J; Zhou, Y1
Chen, Y; Hong, SJ; Liu, L; Liu, M; Liu, XD; Tang, XG; Xie, QS; Xu, J; Yang, HY; Yang, TT; Yang, YT; Zhao, KJ; Zhou, YQ; Zhu, L1
Ge, RS; Hu, Z; Li, H; Li, J; Li, X; Shi, L; Tang, Y; Tian, F; Wang, S; Wang, Y; Zhu, Y1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1

Reviews

1 review(s) available for nad and triclosan

ArticleYear
Recent progress in the identification and development of InhA direct inhibitors of Mycobacterium tuberculosis.
    Mini reviews in medicinal chemistry, 2010, Volume: 10, Issue:3

    Topics: Antitubercular Agents; Bacterial Proteins; Enzyme Inhibitors; Isoniazid; Mycobacterium tuberculosis; NAD; Oxidoreductases; Pyrazoles; Triclosan

2010

Other Studies

29 other study(ies) available for nad and triclosan

ArticleYear
Mechanism of triclosan inhibition of bacterial fatty acid synthesis.
    The Journal of biological chemistry, 1999, Apr-16, Volume: 274, Issue:16

    Topics: Enoyl-(Acyl-Carrier-Protein) Reductase (NADH); Fatty Acids; Models, Molecular; Molecular Structure; Mutation, Missense; NAD; Oxidoreductases; Protein Binding; Triclosan

1999
Structural basis and mechanism of enoyl reductase inhibition by triclosan.
    Journal of molecular biology, 1999, Jul-23, Volume: 290, Issue:4

    Topics: Anti-Bacterial Agents; Boron Compounds; Crystallography; Drug Resistance, Microbial; Enoyl-(Acyl-Carrier-Protein) Reductase (NADH); Enzyme Inhibitors; Escherichia coli; Escherichia coli Proteins; Fatty Acid Synthase, Type II; Models, Molecular; NAD; Oxidoreductases; Triclosan

1999
Kinetic and structural characteristics of the inhibition of enoyl (acyl carrier protein) reductase by triclosan.
    Biochemistry, 1999, Sep-21, Volume: 38, Issue:38

    Topics: Anti-Infective Agents, Local; Binding, Competitive; Catalysis; Chromatography, Gel; Crystallization; Crystallography, X-Ray; Dose-Response Relationship, Drug; Enoyl-(Acyl-Carrier-Protein) Reductase (NADH); Enzyme Inhibitors; Escherichia coli Proteins; Fatty Acid Synthase, Type II; Kinetics; Mass Spectrometry; Models, Chemical; NAD; Oxidoreductases; Structure-Activity Relationship; Triclosan

1999
Molecular basis for triclosan activity involves a flipping loop in the active site.
    Protein science : a publication of the Protein Society, 1999, Volume: 8, Issue:11

    Topics: Amino Acid Sequence; Anti-Infective Agents, Local; Binding Sites; Crystallography, X-Ray; Enoyl-(Acyl-Carrier-Protein) Reductase (NADH); Escherichia coli; Hydrogen Bonding; Isoleucine; Models, Molecular; Molecular Sequence Data; NAD; Oxidoreductases; Protein Conformation; Serine; Triclosan

1999
Triclosan offers protection against blood stages of malaria by inhibiting enoyl-ACP reductase of Plasmodium falciparum.
    Nature medicine, 2001, Volume: 7, Issue:2

    Topics: Amino Acid Sequence; Animals; Antimalarials; Disease Models, Animal; Enoyl-(Acyl-Carrier-Protein) Reductase (NADH); Fatty Acids; Malaria; Mice; Mice, Inbred BALB C; Molecular Sequence Data; NAD; Oxidoreductases; Plasmodium berghei; Plasmodium falciparum; Triclosan

2001
Structural basis for triclosan and NAD binding to enoyl-ACP reductase of Plasmodium falciparum.
    Biochemical and biophysical research communications, 2001, Apr-27, Volume: 283, Issue:1

    Topics: Animals; Brassica; Computer Simulation; Drug Design; Enoyl-(Acyl-Carrier-Protein) Reductase (NADH); Ligands; Models, Chemical; Models, Molecular; NAD; Oxidoreductases; Plasmodium falciparum; Structure-Activity Relationship; Substrate Specificity; Triclosan

2001
Enoyl-ACP reductase (FabI) of Haemophilus influenzae: steady-state kinetic mechanism and inhibition by triclosan and hexachlorophene.
    Archives of biochemistry and biophysics, 2001, Jun-01, Volume: 390, Issue:1

    Topics: Binding Sites; Enoyl-(Acyl-Carrier-Protein) Reductase (NADH); Enzyme Inhibitors; Haemophilus influenzae; Hexachlorophene; Kinetics; Models, Chemical; NAD; Oxidoreductases; Triclosan

2001
A study of the structure-activity relationship for diazaborine inhibition of Escherichia coli enoyl-ACP reductase.
    Journal of molecular biology, 2001, May-25, Volume: 309, Issue:1

    Topics: Binding Sites; Boron Compounds; Crystallography, X-Ray; Enoyl-(Acyl-Carrier-Protein) Reductase (NADH); Enzyme Inhibitors; Escherichia coli; Models, Molecular; NAD; Oxidoreductases; Protein Binding; Protein Conformation; Protein Subunits; Structure-Activity Relationship; Triclosan

2001
Kinetic determinants of the interaction of enoyl-ACP reductase from Plasmodium falciparum with its substrates and inhibitors.
    Biochemical and biophysical research communications, 2001, Dec-14, Volume: 289, Issue:4

    Topics: Acyl Coenzyme A; Animals; Antimalarials; Cloning, Molecular; Drug Design; Drug Resistance; Enoyl-(Acyl-Carrier-Protein) Reductase (NADH); Enzyme Inhibitors; Escherichia coli; Escherichia coli Proteins; Fatty Acid Synthase, Type II; Fatty Acid Synthases; Humans; Kinetics; Malaria, Falciparum; NAD; Oxidoreductases; Plasmodium falciparum; Recombinant Proteins; Substrate Specificity; Triclosan

2001
Characterization of a novel enoyl-acyl carrier protein reductase of diazaborine-resistant Rhodobacter sphaeroides mutant.
    Biochemical and biophysical research communications, 2002, Dec-13, Volume: 299, Issue:4

    Topics: Amino Acid Sequence; Anti-Infective Agents, Local; Bacterial Proteins; Binding Sites; Boron Compounds; Drug Resistance, Bacterial; Enoyl-(Acyl-Carrier-Protein) Reductase (NADH); Isoenzymes; Molecular Sequence Data; Mutagenesis, Site-Directed; NAD; Oxidoreductases; Point Mutation; Rhodobacter sphaeroides; Sequence Alignment; Triclosan

2002
Exploring the interaction energies for the binding of hydroxydiphenyl ethers to enoyl-acyl carrier protein reductases.
    Journal of biomolecular structure & dynamics, 2003, Volume: 20, Issue:4

    Topics: Animals; Bacillus; Enoyl-(Acyl-Carrier Protein) Reductase (NADPH, B-Specific); Enoyl-(Acyl-Carrier-Protein) Reductase (NADH); Enzyme Inhibitors; Escherichia coli; Escherichia coli Proteins; Fatty Acids; Hexachlorophene; Molecular Structure; NAD; NADP; Oxidoreductases; Phenyl Ethers; Plasmodium falciparum; Protein Conformation; Protozoan Proteins; Staphylococcus aureus; Substrate Specificity; Thermodynamics; Triclosan

2003
Expression, purification and crystallization of the Plasmodium falciparum enoyl reductase.
    Acta crystallographica. Section D, Biological crystallography, 2003, Volume: 59, Issue:Pt 7

    Topics: Animals; Carrier Proteins; Cloning, Molecular; Crystallization; Enoyl-(Acyl-Carrier-Protein) Reductase (NADH); Enzyme Inhibitors; Maltose-Binding Proteins; NAD; Oxidoreductases; Plasmodium falciparum; Recombinant Fusion Proteins; Triclosan; X-Ray Diffraction

2003
Inhibition of the bacterial enoyl reductase FabI by triclosan: a structure-reactivity analysis of FabI inhibition by triclosan analogues.
    Journal of medicinal chemistry, 2004, Jan-29, Volume: 47, Issue:3

    Topics: Anti-Bacterial Agents; Bacteria; Crystallography, X-Ray; Enoyl-(Acyl-Carrier-Protein) Reductase (NADH); Microbial Sensitivity Tests; Models, Molecular; Mutation; NAD; Oxidoreductases; Protein Binding; Structure-Activity Relationship; Thermodynamics; Triclosan

2004
Kinetic and structural analysis of the increased affinity of enoyl-ACP (acyl-carrier protein) reductase for triclosan in the presence of NAD+.
    The Biochemical journal, 2004, Aug-01, Volume: 381, Issue:Pt 3

    Topics: Alanine; Animals; Asparagine; Carbon-Carbon Ligases; Cloning, Molecular; Crystallography, X-Ray; Enoyl-(Acyl-Carrier-Protein) Reductase (NADH); NAD; Niacinamide; Oxidoreductases; Plasmodium falciparum; Protein Binding; Structure-Activity Relationship; Substrate Specificity; Surface Plasmon Resonance; Triclosan

2004
Mutational analysis of the triclosan-binding region of enoyl-ACP (acyl-carrier protein) reductase from Plasmodium falciparum.
    The Biochemical journal, 2004, Aug-01, Volume: 381, Issue:Pt 3

    Topics: Amino Acid Sequence; Animals; Binding Sites; Chromatography, Gel; Circular Dichroism; Electrophoresis, Polyacrylamide Gel; Enoyl-(Acyl-Carrier-Protein) Reductase (NADH); Molecular Sequence Data; Mutagenesis, Site-Directed; NAD; Oxidoreductases; Plasmodium falciparum; Protein Structure, Quaternary; Triclosan

2004
Structural basis for the variation in triclosan affinity to enoyl reductases.
    Journal of molecular biology, 2004, Oct-08, Volume: 343, Issue:1

    Topics: Brassica; Crystallography, X-Ray; Enoyl-(Acyl-Carrier-Protein) Reductase (NADH); Genetic Variation; Hydrogen Bonding; Models, Molecular; Molecular Structure; NAD; Oxidoreductases; Protein Binding; Protein Structure, Tertiary; Structure-Activity Relationship; Substrate Specificity; Triclosan; Water

2004
Expression, purification and preliminary crystallographic analysis of the Toxoplasma gondii enoyl reductase.
    Acta crystallographica. Section F, Structural biology and crystallization communications, 2006, Jun-01, Volume: 62, Issue:Pt 6

    Topics: Animals; Antiprotozoal Agents; Crystallization; Enoyl-(Acyl-Carrier-Protein) Reductase (NADH); NAD; Protozoan Proteins; Solvents; Toxoplasma; Triclosan; X-Ray Diffraction

2006
Insight through molecular mechanics Poisson-Boltzmann surface area calculations into the binding affinity of triclosan and three analogues for FabI, the E. coli enoyl reductase.
    Journal of medicinal chemistry, 2006, Jul-27, Volume: 49, Issue:15

    Topics: Binding Sites; Enoyl-(Acyl-Carrier-Protein) Reductase (NADH); Escherichia coli Proteins; Fatty Acid Synthase, Type II; Hydrogen Bonding; Models, Molecular; NAD; Protein Binding; Quantitative Structure-Activity Relationship; Thermodynamics; Triclosan

2006
Studies of Toxoplasma gondii and Plasmodium falciparum enoyl acyl carrier protein reductase and implications for the development of antiparasitic agents.
    Acta crystallographica. Section D, Biological crystallography, 2007, Volume: 63, Issue:Pt 3

    Topics: Amino Acid Sequence; Animals; Antimalarials; Antiparasitic Agents; Apoenzymes; Bacterial Proteins; Binding Sites; Crystallography, X-Ray; Drug Design; Enoyl-(Acyl-Carrier-Protein) Reductase (NADH); Models, Molecular; Molecular Sequence Data; NAD; Plant Proteins; Plasmodium falciparum; Protein Conformation; Sequence Alignment; Species Specificity; Toxoplasma; Triclosan; Water

2007
Biochemical characterization of enoyl reductase involved in Type II fatty acid synthesis in the intestinal coccidium Eimeria tenella (Phylum Apicomplexa).
    FEMS microbiology letters, 2007, Volume: 272, Issue:2

    Topics: Animals; Cloning, Molecular; Coenzyme A; Coenzymes; DNA, Protozoan; Eimeria tenella; Enzyme Inhibitors; Fatty Acid Desaturases; Gene Expression; Microscopy, Confocal; Molecular Sequence Data; NAD; Organelles; Recombinant Proteins; Sequence Analysis, DNA; Triclosan

2007
Mechanism and inhibition of the FabV enoyl-ACP reductase from Burkholderia mallei.
    Biochemistry, 2010, Feb-16, Volume: 49, Issue:6

    Topics: Bacterial Proteins; Burkholderia mallei; Catalysis; Catalytic Domain; Enoyl-(Acyl-Carrier-Protein) Reductase (NADH); Gene Expression Regulation, Bacterial; Hydrogen-Ion Concentration; Kinetics; Mutagenesis, Site-Directed; NAD; Protein Binding; Substrate Specificity; Triclosan

2010
Structure of the Francisella tularensis enoyl-acyl carrier protein reductase (FabI) in complex with NAD(+) and triclosan.
    Acta crystallographica. Section F, Structural biology and crystallization communications, 2010, Nov-01, Volume: 66, Issue:Pt 11

    Topics: Crystallography, X-Ray; Enoyl-(Acyl-Carrier-Protein) Reductase (NADH); Enzyme Inhibitors; Francisella tularensis; Models, Molecular; NAD; Protein Binding; Protein Structure, Tertiary; Structural Homology, Protein; Triclosan

2010
Crystallization and preliminary X-ray crystallographic studies of enoyl-acyl carrier protein reductase (FabI) from Psuedomonas aeruginosa.
    Acta crystallographica. Section F, Structural biology and crystallization communications, 2011, Feb-01, Volume: 67, Issue:Pt 2

    Topics: Apoenzymes; Bacterial Proteins; Crystallization; Crystallography, X-Ray; Enoyl-(Acyl-Carrier-Protein) Reductase (NADH); Fatty Acid Synthases; Molecular Weight; NAD; Pseudomonas aeruginosa; Triclosan; X-Ray Diffraction

2011
Dynamics of Plasmodium falciparum enoyl-ACP reductase and implications on drug discovery.
    Protein science : a publication of the Protein Society, 2012, Volume: 21, Issue:11

    Topics: Binding Sites; Computer-Aided Design; Drug Discovery; Enoyl-(Acyl-Carrier-Protein) Reductase (NADH); Hydrogen Bonding; Ligands; Molecular Dynamics Simulation; NAD; Plasmodium falciparum; Protein Binding; Triclosan

2012
High-resolution structures of Thermus thermophilus enoyl-acyl carrier protein reductase in the apo form, in complex with NAD+ and in complex with NAD+ and triclosan.
    Acta crystallographica. Section F, Structural biology and crystallization communications, 2012, Oct-01, Volume: 68, Issue:Pt 10

    Topics: Amino Acid Sequence; Apoenzymes; Enoyl-(Acyl-Carrier-Protein) Reductase (NADH); Enzyme Stability; Models, Molecular; Molecular Sequence Data; NAD; Protein Binding; Protein Structure, Quaternary; Sequence Alignment; Structural Homology, Protein; Thermus thermophilus; Triclosan

2012
Discrimination of potent inhibitors of Toxoplasma gondii enoyl-acyl carrier protein reductase by a thermal shift assay.
    Biochemistry, 2013, Dec-23, Volume: 52, Issue:51

    Topics: Antiprotozoal Agents; Bacterial Proteins; Cell Proliferation; Cells, Cultured; Drug Design; Enoyl-(Acyl-Carrier-Protein) Reductase (NADH); Enzyme Inhibitors; Fibroblasts; High-Throughput Screening Assays; Hot Temperature; Humans; Inhibitory Concentration 50; Kinetics; Luminescent Proteins; Molecular Conformation; Molecular Docking Simulation; NAD; Oxidation-Reduction; Protein Unfolding; Protozoan Proteins; Recombinant Proteins; Toxoplasma; Triclosan

2013
Characteristics of β-oxidative and reductive metabolism on the acyl side chain of cinnamic acid and its analogues in rats.
    Acta pharmacologica Sinica, 2019, Volume: 40, Issue:8

    Topics: Animals; Cinnamates; Fatty Acids; Hepatocytes; Male; Methacrylates; Microsomes, Liver; Mitochondria, Liver; Molecular Structure; NAD; Oxidation-Reduction; Pyrazines; Rats, Sprague-Dawley; Triclosan

2019
Inhibition of human and rat placental 3β-hydroxysteroid dehydrogenase/Δ
    Chemico-biological interactions, 2023, Jan-05, Volume: 369

    Topics: Animals; Female; Fungicides, Industrial; Humans; Insecticides; Isomerases; Multienzyme Complexes; NAD; Placenta; Pregnancy; Pregnenolone; Rats; Triclosan

2023
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010